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[SciELO Preprints] - Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy – 2024
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Fernandes, Fabio Simões, Marcus V. Correia, Edileide de Barros Marcondes-Braga, Fabiana G. Coelho-Filho, Otavio Rizzi Mesquita, Cláudio Tinoco Mathias-Junior, Wilson Rochitte, Carlos Eduardo Ramires, Felix José Alvarez Alves, Silvia Marinho Martins Montera, Marcelo Westerlund Lopes, Renato Delascio Oliveira-Junior, Mucio Tavares Scolari, Fernando L. Avila, Walkiria Samuel Canesin, Manoel Fernandes Bacal, Fernando Bocchi, Edimar Alcides Moura, Lídia Ana Zytynski Saad, Eduardo Benchimol Scanavacca, Mauricio I. Valdigem, Bruno Pereira Cano , Manuel Nicolas Abizaid , Alexandre Ribeiro, Henrique Barbosa Lemos-Neto, Pedro Alves Ribeiro, Gustavo Calado de Aguiar Jatene, Fabio Biscegli Dias, Ricardo Ribeiro Beck-da-Silva, Luis Rohde, Luis Eduardo P. Bittencourt, Marcelo Imbroinise Pereira, Alexandre Krieger, José Eduardo Villacorta, Humberto Martins, Wolney de Andrade Figueiredo-Neto, José Albuquerque de Cardoso , Juliano Novaes Pastore, Carlos Alberto Jatene, Ieda Biscegli Tanaka, Ana Cristina Sayuri Hotta, Viviane Tiemi Romano, Minna Moreira Dias Albuquerque, Denilson Campos de Mourilhe-Rocha, Ricardo Hajjar, Ludhmila Abrahão Brito, Fabio Sandoli de Caramelli , Bruno Calderaro, Daniela Farsky, Pedro Silvio Colafranceschi , Alexandre Siciliano Pinto, Ibraim Masciarelli Vieira , Marcelo Luiz Campos Danzmann, Luiz Claudio Barberato , Silvio Henrique Mady, Charles Martinelli-Filho, Martino Torbey , Ana Flavia Malheiros Schwartzmann, Pedro Vellosa Macedo, Ariane Vieira Scarlatelli Ferreira , Silvia Moreira Ayub Schmidt, Andre Melo , Marcelo Dantas Tavares de Lima-Filho, Moysés Oliveira Sposito, Andrei C. Brito, Flavio de Souza Biolo, Andreia Madrini-Junior, Vagner Rizk, Stéphanie Itala Mesquita, Evandro Tinoco

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Publication date: 2024-04-08

Abstract: Pt Es En

A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE.   Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).

La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).

Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.

https://doi.org/10.1590/SciELOPreprints.8394

Fertigation with copper in beet crop in a semi-arid region
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Costa, Romualdo M. C.

; Grangeiro, Leilson C.

; Lima, Renner B. de

; Pereira, Natali A. E.

; Costa, João P. N. da

; Alves, Anderson A.

; Bezerra, Larisa R. F. C.

; Lacerda, Rodolfo R. de A.

; Sá, Francisco V. da S.

; Fernandes, Bruno C. C.

; Chagas, Paulo S. F. das

Revista Brasileira de Engenharia Agrícola e Ambiental

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mar 2024, Volume 28 N. 3 elocation e276908

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Copper is an essential element for beet; however, it needs to be made available in adequate quantities since this nutrient, which is a heavy metal, can cause toxicity to plants and/or humans. This study aimed to evaluate the agronomic performance of beet fertigated with copper in a semi-arid region of Brazil. Two experiments were carried out in complete randomized blocks, with five treatments (0, 1.5, 3.0, 4.0, and 6.0 kg ha-1 of copper) and four replicates. In 2019, the copper content was within the adequate range for beet. In 2021, fertigation with copper above 0.8 kg ha-1 led to contents in the phytotoxicity range, which may explain the reduction in total and tuberous root dry mass accumulation. Fertilization with copper increased marketable yield in 2019 (17.32 t ha-1 at the dose of 3.9 kg ha-1 of copper), while, in 2021, there was no fit of the equations. Copper fertilization altered the tuberous root pH but did not influence the other tuberous root quality components. Plants fertilized with copper accumulated more copper in the leaves than in the tuberous root, with a maximum accumulation of 6.0 kg ha-1 of copper in 2019 and 2021. Fertilization with 3.9 kg ha-1 suits soils with low copper content.

RESUMO O cobre é um elemento essencial à beterraba, no entanto, é necessário disponibilizá-lo em quantidade adequada uma vez que esse nutriente, que é um metal pesado, pode causar toxicidade às plantas e, ou, ao ser humano. Esta pesquisa teve como objetivo avaliar o desempenho agronômico de beterraba fertirrigada com cobre em uma região semiárida do Brasil. Foram conduzidos dois experimentos em delineados em blocos casualizados ao acaso, com cinco tratamentos (0, 1.5, 3.0, 4.5 e 6.0 kg ha-1 de cobre) e quatro repetições. Em 2019, o teor de cobre estava dentro da faixa adequada para a beterraba. Em 2021, a fertirrigação com cobre acima de 0.8 kg ha-1 proporcionou teores na faixa de fitotoxicidade, o que pode explicar a redução no acúmulo de massa seca total e de raízes tuberosas. A adubação com cobre aumentou a produtividade comercial em 2019 (17.32 t ha-1 na dose de 3.9 kg ha-1 de cobre) enquanto que, em 2021, não houve modelo ajustado. A adubação alterou o pH da raiz tuberosa, mas não influenciou nos demais atributos de qualidade pós-colheita da raiz tuberosa. Plantas adubadas com cobre acumularam mais cobre nas folhas do que na raiz tuberosa, com máxima acumulada em 2019 e em 2021, na dose 6.0 kg ha-1 de cobre. A adubação com 3.9 kg ha-1 é adequada para solos com baixo teor de cobre.

https://doi.org/10.1590/1807-1929/agriambi.v28n3e276908

Costurando a cidade: crise do capital, urbanização logística e entregadores de aplicativo
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Fernandes, Bruno Siqueira

; Peregalli, Alessandro

; Canettieri, Thiago

Cadernos Metrópole

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jan 2024, Volume 26 N. 59 Pages 97 - 121

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract In the context of the recent transformations undergone by work in Brazilian metropolises, there has been a multiplication of precarious jobs related to circulation of goods. The crisis of capital and of the value-form seem to be giving rise to the need of efficient circulation as a condition for accumulation, which is reflected in the so- -called logistical urbanization. The article presents an interpretation of these processes based on Lefebvre’s levels of analysis of the urban (G-M-P). By exploring the relationship between crisis of capital, logistical urbanization, and the everyday dimension of app-based delivery workers, we conclude that the precarization of work and the production of logistical infrastructures emerge as material expressions of the increasing crisis of the valorization of value; at the same time, they alter the forms of struggle of the working class.

Resumo Considerando as recentes transformações do trabalho nas metrópoles brasileiras, observa-se uma multiplicação do trabalho precário baseado na circulação de mercadorias. A crise do capital e da forma-valor parece dar origem a um imperativo de circulação eficiente como condição de possibilidade para a acumulação, que se reflete na chamada urbanização logística. Este artigo apresenta uma interpretação desses processos a partir da perspectiva lefebvriana dos níveis de análise do urbano (G-M-P). Ao explorar a relação entre crise do capital, urbanização logística e a dimensão cotidiana dos entregadores de aplicativo, concluímos que a precarização do trabalho e a produção de infraestruturas logísticas aparecem como expressão material do aprofundamento da crise da valorização do valor, alterando simultaneamente as formas de luta da classe trabalhadora.

https://doi.org/10.1590/2236-9996.2024-5905

Numerical sensitivity analysis for stress-strain simulation and flow liquefaction assessment of tailings storage facilities using the NorSand constitutive model
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Costa, Filipe Fernandes Souza

; Delgado, Bruno Guimarães

; Castilho, Breno de Matos

Soils and Rocks

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2024, Volume 47 N. 1 elocation e2024011322

Abstract: En | Text: En | PDF: En

Abstract With the advent of critical state Soil Mechanics (CSSM), the void ratio began to be recognized as a key parameter, along with the stress state, which defines the mechanical behavior of soils and other particulate geomaterials by using the state parameter. The state parameter is the difference between the current and critical void ratio so that its definition requires the critical state line (CSL) identification. This work presents numerical calibration results, using the NorSand constitutive model, from three sets of triaxial compression tests selected from the literature. The SIGMA/W module of the Geostudio® System was adopted to perform the simulations of the triaxial compression tests, and the results showed adequate fit between real tests and numerical simulations. The parameters necessary for the modeling with NorSand model, defined from the numerical calibration, were used in a stress-strain evaluation of a hypothetical upstream tailings dam. These simulations allowed the evaluation of the differences in the tailings storage facility (TSF) responses in terms of both deformation behavior and flow liquefaction instability. Flow liquefaction instability is described in the literature as a complete loss in shear strength and the development of excessive strains due to the contractive response of tailings when subjected to low confining stress. The results suggest that the use of the NorSand model is, in general, a good option to reproduce the typical strain-softening behavior of such structures. Furthermore, it was clear the high sensitivity of the constitutive model parameters, drawing attention to the importance of best laboratory practices for carrying out triaxial tests to obtain reliable parameters for NorSand modeling.

https://doi.org/10.28927/sr.2024.011322

Post-COVID-19 functional capacity assessed with ring and walk tests: cross-sectional study
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Tozato, Claudia

; Molinari, Camila Vitelli

; Ferreira, Bruno Fernandes Costa

; Xavier, Vivian Bertoni

; Alves, Vera Lúcia dos Santos

Fisioterapia em Movimento

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2024, Volume 37 elocation e37102

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Introduction COVID-19 can cause persistent symptoms even in mild cases, such as fatigue and dyspnea, which can reduce functional capacity and make it difficult to perform activities of daily living. Objective To compare functional capacity using the pegboard and ring test and the six-minute walk test responses in post-COVID-19 patients according to the ventilatory support used. Methods Cross-sectional study including 40 adults of both sexes after SARS-CoV2 infection between June 2020 and June 2021, with assessment of functional capacity using the pegboard and ring test (upper limbs) and the six-minute walk (lower limbs). Those who reported comprehension deficit or neuromuscular disease were excluded. All participants were evaluated between 15 and 90 days after the onset of symptoms, diagnosed by nasal swab and classified according to the ventilatory support used during the infection. Results The mean age of the participants (n = 40) was 54.30 (±12.76) years, with BMI 28.39 (±4.70) kg/m2 and pulmonary involvement in 51.49 (±17.47)%. A total of 37 participants were hospitalized with a stay of 14.33 (±15.44) days, and 30% were previously immunized, while 7.5% reached the predicted distance covered. The average achieved was 46.44% (398.63 ± 130.58 m) in the distance covered and 39.31% (237.58 ± 85.51) in the movement of rings. Participants who had invasive mechanical ventilation (n = 10) had the worst functional capacity in both tests 265.85 ± 125.11 m and 181.00 ± 90.03 rings, compared to 472.94 ± 88.02 m and 273.25 ± 66.09 rings in non-invasive ventilation (n = 8), 410.32 ± 90.39 m and 257.68 ± 62.84 rings in oxygen therapy (n = 19), 569.00 ± 79.50 m and 203.00 ± 169.00 rings when there was no hospitalization (n = 3). Conclusion Participants who required invasive mechanical ventilation had worse functional capacity, 46% of what was expected in the walk test and 39% of what was expected in the pegboard and ring test.

Resumo Introdução A COVID-19 pode causar sintomas per-sistentes mesmo nos casos leves, como fadiga e dispneia, que podem reduzir a capacidade funcional e a realização das atividades de vida diária. Objetivo Comparar a avaliação da capacidade funcional a partir do teste da argola e caminhada dos 6 minutos pós-COVID-19 con-forme o suporte ventilatório utilizado. Métodos: Estudo transversal com 40 adultos, de ambos os sexos, pós-infecção por SARS-CoV2 entre julho/2020 e julho 2021, com avaliação da capacidade funcional pelos testes da argola (membros superiores) e caminhada (membros inferiores) de 6 minutos. Todos os participantes foram avaliados entre 15 e 90 dias do princípio dos sintomas, diagnosticados por swab nasal, e classificados conforme o suporte ventilatório utilizado durante a infecção. Resultados A média de idade dos participantes (n = 40) foi 54,30 (±12,76) anos, índice de massa corporal 28,39 (±4,70) kg/m2 e acometimento pulmonar em vidro fosco 51,49 (±17,47)%. Trinta e sete participantes foram hospitalizados com permanência de 14,33 (±15,44) dias, 30% previamente imunizados; 7,5% atingiram o predito da distância percorrida. A média alcançada foi de 46,44% (398,63 ± 130,58 m) na distância percorrida e 39,31% (237,58 ± 85,51) em movimento de argolas. Os participantes que utilizaram ventilação mecânica invasiva (n = 10) apresentaram pior capacidade funcional em ambos os testes: 265,85 ± 125,11 m e 181,00 ± 90,03 argolas comparado a 472,94 ± 88,02 m e 273,25 ± 66,09 argolas em ventilação não invasiva (n = 8), 410,32 ± 90,39m e 257,68 ± 62,84 argolas em oxigenoterapia (n = 19), 569,00 ± 79,50 m e 203,00 ± 169,00 argolas sem internação (n = 3). Conclusão Os participantes que necessitaram de ventilação mecânica invasiva apresen-taram pior capacidade funcional, com 46% do esperado no teste de caminhada e 39% no teste de argola de 6 minutos.

https://doi.org/10.1590/fm.2024.37102

Embarazo en adolescentes en el Servicio de Maternidad del Hospital Regional de Pedro Juan Caballero entre diciembre de 2021 a noviembre de 2022
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Guarnieri-Granero, Samuel

; Buscioli-Teixeira, Renata

; Pereira-Nunes, Auricelio

; Gea-Fernandes, Bruno Felipe

; Santos-Filho, Eduardo Costa

; Barreto-Román, Sergio Adrián

Revista científica ciencias de la salud

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2024, Volume 6 elocation e6135

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Introduction. Adolescence is a period of biopsychosocial development that goes from 10 to 19 years old. Pregnancy between these ages is a concern for public health due to everything it entails. Objetive. to know the frequency of teenage pregnant women treated in the maternity service of the Pedro Juan Caballero Regional Hospital in the period from December 2021 to November 2022. Material and Method. Descriptive, retrospective cross-sectional, convenience sampling of adolescents treated in the Gynecology service of the Pedro Juan Caballero Regional Hospital in the period December 2021 to November 2022. Results. 20% of the total pregnant women attended were adolescents, 26% of the adolescents were 19 years old, marital status, common-law union 74.5%. 38.2% had at least 5 prenatal checkups. In the Obstetric Gynecological History, 81% were nulliparous. The weight of the 317 children was 2501 to 4000 grams in 83% and in the APGAR score 98.7% had a score of 7-10; 82% were born between 37-42 weeks and 50.3% were boys. The most common route of delivery was vaginal with 73% and cephalic presentation in 97%. Conclusion. The frequency of pregnant adolescents represents a fifth of the total pregnant women attended, more than two thirds were born with adequate weight, mostly an APGAR of 7-10 at 5 minutes and the route by which they were mostly born was vaginal, in cephalic presentation.

RESUMEN Introducción. La adolescencia es un periodo de desarrollo biopsicosocial que va desde los 10 a 19 años, el embarazo entre estas edades supone una preocupación para la salud pública por todo lo que conlleva. Objetivo. Conocer la frecuencia y características clínico-epidemiológicas de gestantes adolescentes atendidas en el servicio de maternidad del Hospital Regional de Pedro Juan Caballero entre diciembre del 2021 a noviembre del 2022 Materiales y Método. Estudio descriptivo, retrospectivo de corte transversal, muestreo por conveniencia de adolescentes atendidas en el servicio de ginecología del Hospital Regional de Pedro Juan Caballero en el periodo diciembre 2021 a noviembre del 2022. Resultados. De 1615 puérperas, el 20% (n=317) fueron adolescentes, 26% de ellas tenían 19 años, 78,5% en unión libre, 38,2% tenía por lo menos 5 controles prenatales. En los antecedentes gineco obstétricos el 81% eran nulíparas. El peso de los 317 niños fue 2501 a 4000 gramos en un 83% y en puntaje APGAR 98,7% presentó un puntaje de 7-10; 82% nació entre 37-42 semanas y 50,3% fueron varones. La vía de parto más común fue la vaginal con 73% y de presentación cefálica en un 97%. Conclusión. La frecuencia de gestantes adolescentes representa una quinta parte del total de gestantes atendidas, más de dos tercios nacieron con peso adecuado, en su mayoría un APGAR de 7-10 a los 5 minutos y la vía por la cual nacieron en su mayoría fue la vaginal, en presentación cefálica.

https://doi.org/10.53732/rccsalud/2024.e6135

Life Cycle Stages and Debt Maturity in Brazilian Listed Companies
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Bregonci, Leonardo Valter

; Marques, Vagner Antônio

; Pinto, Bruno Magri Magalhães

; Amaral, Hudson Fernandes

BBR. Brazilian Business Review

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jul 2023, Volume 20 N. 4 Pages 407 - 425

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT We have analyzed the association between firms' life cycle stages (LCSs) and their debt maturity (DM). This paper deepens the discussion on capital structure from the perspective of the LCSs' dynamic effect associated with DM. The sample was composed by secondary data from 370 (non-financial) Brazilian listed companies in the period from 2010 to 2019, gathered quarterly. The data were analyzed through descriptive statistics, tests of differences between means and regression analysis from panel data. The results showed that the DM presents no association with LCS, following an inverted U-shape. It has been observed that the maturity stage had a positive effect on the DM, however, as companies move towards the shake-out and decline stages, DM experiences successive reductions. The findings are relevant for providing insights for future research. In addition, they have the potential to contribute to managers, board members, credit committees, capital providers in general, risk management process, and resource allocation.

RESUMO Este trabalho analisou a associação entre os Estágios do Ciclo de Vida da Firma (ECVs) e a Maturidade da Dívida (MD). O estudo aprofunda as discussões sobre estrutura de capital a partir da análise do efeito dinâmico dos ECVs associados à MD das empresas brasileiras. A amostra foi composta por dados trimestrais de 370 empresas (não financeiras) brasileiras listadas no período de 2010 a 2019. Os dados foram analisados por meio da estatística descritiva, testes de diferenças entre as médias e análise de regressão com dados em painel. Os resultados demonstraram uma MD associação com os ECVs, seguindo um formato de U invertido. Observou-se que o estágio de Maturidade afeta positivamente a MD, contudo, à medida que as empresas transitam em direção ao estágio de Turbulência e Declínio, a MD sofre reduções sucessivas. Os achados são relevantes por proporcionarem insights para pesquisas futuras e apresentarem potencial de contribuição para gestores, conselheiros de administração, comitês de crédito e provedores de capital em geral na análise de crédito das empresas, gestão de riscos e concessão de recursos.

https://doi.org/10.15728/bbr.2022.1223.en

EXPERIÊNCIA DA UTILIZAÇÃO DE APLICATIVOS MÓVEIS EM PESSOAS COM DOENÇA ONCOLÓGICA DURANTE O TRATAMENTO DE QUIMIOTERAPIA: PROTOCOLO DE REVISÃO SISTEMÁTICA QUALITATIVA
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Magalhães, Bruno

; Fernandes, Carla Sílvia

; Gonçalves, Filipe

; Santos, Célia

; Barbieri-Figueiredo, Maria do Céu

Revista Onconews

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jun 2023, N. 46 elocation e093

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract: Introduction: Identifying the perception or experiences associated with the use of mobile applications (mHealth) during chemotherapy treatment is essential to ensure patient involvement. This identification is also fundamental in the development process of this type of solutions. Thus, the present study intended to synthesize the knowledge produced about the perceptions or experiences of people with oncological disease resulting from the use of mobile applications, used during chemotherapy treatment. Inclusion Criteria: The review will consider all primary studies with a qualitative methodological approach, published in English, French, Spanish or Portuguese, until December 31, 2022. Methods: The review will be conducted according to the JBI methodology for systematic reviews of qualitative evidence. Electronic databases MEDLINE®, CINAHL®, Psychology and Behavioral Sciences Collection, Scopus® and Cochrane Library will be used to identify primary studies. Data extraction will be performed using a tool developed by the researchers, based on the JBI model (JBI QARI Data Extraction Tool for Qualitative Research). Extracted data will, where possible, pooled using a meta-aggregation approach. The summary of the findings will be presented using ConQual in order to assess the confidence in the findings. Systematic review registration number: PROSPERO (CRD42020213811).

Resumo: Introdução: A identificação da perceção ou experiências associadas à utilização de aplicativos móveis (mHealth) durante o tratamento de quimioterapia é essencial para garantir o envolvimento do doente e fundamental no processo de desenvolvimento deste tipo de soluções. Com a realização do presente estudo pretende-se sintetizar o conhecimento produzido acerca das perceções ou experiências das pessoas com doença oncológica resultantes do uso de aplicativos móveis, utilizados durante o tratamento de quimioterapia. Critérios de Inclusão: A revisão considerará estudos primários com abordagem metodológica de índole qualitativa que explorem as perceções ou experiências de doentes adultos, em tratamento exclusivo de quimioterapia, acerca da utilização de aplicativos móveis usados como suporte durante o tratamento de quimioterapia. Serão considerados todos os trabalhos publicados em inglês, francês, espanhol ou português, até 31 de dezembro de 2022. Métodos: A revisão será conduzida de acordo com a metodologia JBI para revisões sistemáticas de evidências qualitativas. Recorrer-se-á às bases de dados eletrónicas MEDLINE®, CINAHL®, Psychology and Behavioral Sciences Collection, Scopus® e Cochrane Library empregando os respetivos termos-chave e operadores booleanos para a identificação dos estudos primários. A extração dos dados será realizada através de uma ferramenta desenvolvida pelos investigadores, com base no modelo da JBI (JBI QARI Data Extraction Tool for Qualitative Research). Os dados extraídos serão, sempre que possível, agrupados usando uma abordagem de meta-agregação. O resumo das constatações será apresentado com recurso ao ConQual de forma a avaliar-se a confiança nos achados. Número de registo da revisão sistemática: PROSPERO (CRD42020213811).

https://doi.org/10.31877/on.2023.46.02

Choledochal cyst
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Suda Rodrigues, Bruna

; Oliveira da Silva, Mayara

; Fernandes Barros Brehme de Abreu, Bruno

; Duarte, Márcio L.

; Duarte, Élcio R.

Medicina (Buenos Aires)

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apr 2023, Volume 83 N. 1 Pages 180 - 180

Abstract: En | Text: En | PDF: En

10.

MODELOS DE GESTÃO DE OFERTA ALIMENTAR EM REFEITÓRIOS ESCOLARES DO ALTO MINHO - COMPARAÇÃO NO ÂMBITO DO PROJETO P0DE
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Rocha, Liliana

; Martins, Catarina

; Afonso, Cláudia

; Oliveira, Bruno

; Gonçalves, Alexandra

; Fernandes, Liliana

; Oliveira, Mariana

; Azevedo, Rute Sá

; Karim, Susana

; Quintas, Susana

; Ferro, Graça

Acta Portuguesa de Nutrição

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mar 2023, N. 32 Pages 6 - 11

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT INTRODUCTION: To reduce the incidence and prevalence of diseases related to eating habits, the School Diet Optimization Project was implemented, which aims to contribute to a school food supply in line with the premises of healthy eating. OBJECTIVES: To compare qualitatively and quantitatively the school food supply related to the lunch meal considering direct and concession management models. METHODOLOGY: Observational cross-sectional study. The School Diet Optimization Project, implemented in 34 public schools in the district of Viana do Castelo, aims to guarantee the offer of varied, normoenergetic, and nutritionally balanced meals that guarantee hygiene and food safety criteria. Data corresponding to one month of each school, between 2014 and 2019, was analyzed. RESULTS: School canteens under direct management fulfilled a higher percentage (82%), on a median, of qualitative criteria of the School Diet Optimization Project, compared to those under concession management (p = 0,022). All canteens with direct management complied with the required frequency of offering fish rich in omega 3 (ω3). These canteens used a greater amount of fat and saturated fat compared to those under concession management (p = 0,030 and 0,040, respectively). The opposite occurred in fiber supply (p = 0,016). CONCLUSIONS: Considering the qualitative assessment, the school canteens under direct management met the School Diet Optimization Project criteria better and offered fish rich in ω3 with greater frequency than those under concession management. Quantitatively, canteens under concession offered meals with lower amounts of fat and saturated fat and higher amounts of fiber.

RESUMO INTRODUÇÃO: De forma a contribuir para a diminuição da incidência e prevalência das doenças relacionadas com os hábitos alimentares, implementou-se o Projeto de Otimização das Dietas Escolares que pretende contribuir para uma oferta alimentar escolar alinhada com as premissas de uma alimentação saudável. OBJETIVOS: Comparar qualitativa e quantitativamente a oferta alimentar escolar referente à refeição do almoço considerando os modelos de gestão direta e concessionada. METODOLOGIA: Estudo observacional de desenho transversal. O Projeto de Otimização das Dietas Escolares, implementado em 34 escolas do ensino público do distrito de Viana do Castelo, tem como objetivo garantir a oferta de refeições variadas, normoenergéticas, nutricionalmente equilibradas e que garantam os critérios de higiene e segurança alimentar. Analisaram-se dados correspondentes a uma avaliação mensal de cada escola, entre 2014 e 2019. RESULTADOS: Os refeitórios com gestão direta cumpriram maior percentagem (82%), em mediana, de critérios qualitativos do Projeto de Otimização das Dietas Escolares, relativamente aos de gestão concessionada (p = 0,022). Todos os refeitórios com gestão direta cumpriram a periodicidade de oferta de peixe rico em ómega-3 (ω3) exigida. Estes utilizaram uma maior quantidade de gordura e gordura saturada comparativamente aos de gestão concessionada (p = 0,030 e 0,040, respetivamente). O contrário ocorreu na oferta de fibra (p = 0,016). CONCLUSÕES: Considerando a avaliação qualitativa, os refeitórios com gestão direta cumpriram melhor os critérios do Projeto de Otimização das Dietas Escolares e ofereceram peixe rico em ω3 com maior periodicidade, relativamente aos com gestão concessionada. Quantitativamente, os refeitórios com gestão concessionada ofereceram refeições com menor quantidade de gordura e gordura saturada e maior quantidade de fibra.

https://doi.org/10.21011/apn.2023.3202

11.

The threshold value for identifying insulin resistance (HOMA-IR) in an admixed adolescent population: A hyperglycemic clamp validated study
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Silva, Cleliani de Cassia da

; Zambon, Mariana Porto

; Vasques, Ana Carolina Junqueira

; Camilo, Daniella Fernandes

; Antonio, Maria Ângela Reis de Góes Monteiro

; Geloneze, Bruno

Archives of Endocrinology and Metabolism

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feb 2023, Volume 67 N. 1 Pages 119 - 125

Abstract: En | Text: En | PDF: En

ABSTRACT Objectives: To validate the homeostasis model assessment (HOMA) of insulin resistance (IR) as a surrogate to the hyperglycemic clamp to measure IR in both pubertal and postpubertal adolescents, and determine the HOMA-IR cutoff values for detecting IR in both pubertal stages. Subjects and methods: The study sample comprised 80 adolescents of both sexes (aged 10-18 years; 37 pubertal), in which IR was assessed with the HOMA-IR and the hyperglycemic clamp. Results: In the multivariable linear regression analysis, adjusted for sex, age, and waist circumference, the HOMA-IR was independently and negatively associated with the clamp-derived insulin sensitivity index in both pubertal (unstandardized coefficient – B = −0.087, 95% confidence interval [CI] = −0.135 to −0.040) and postpubertal (B = −0.101, 95% CI, −0.145 to −0.058) adolescents. Bland-Altman plots showed agreement between the predicted insulin sensitivity index and measured clamp-derived insulin sensitivity index in both pubertal stages (mean = −0.00 for pubertal and postpubertal); all P > 0.05. The HOMA-IR showed a good discriminatory power for detecting IR with an area under the receiver operator characteristic curve of 0.870 (95% CI, 0.718-0.957) in pubertal and 0.861 (95% CI, 0.721-0.947) in postpubertal adolescents; all P < 0.001. The optimal cutoff values of the HOMA-IR for detecting IR were > 3.22 (sensitivity, 85.7; 95% CI, 57.2-98.2; specificity, 82.6; 95% CI, 61.2-95.0) for pubertal and > 2.91 (sensitivity, 63.6; 95% CI, 30.8-89.1, specificity, 93.7; 95%CI, 79.2-99.2) for postpubertal adolescents. Conclusion: The threshold value of the HOMA-IR for identifying insulin resistance was > 3.22 for pubertal and > 2.91 for postpubertal adolescents.

https://doi.org/10.20945/2359-3997000000533

12.

Ground improvement techniques applied to very soft clays: state of knowledge and recent advances
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Almeida, Marcio de Souza Soares de

; Marques, Maria Esther Soares

; Riccio, Mario

; Fagundes, Diego de Freitas

; Lima, Bruno Teixeira

; Polido, Uberescilas Fernandes

; Cirone, Alessandro

; Hosseinpour, Iman

Soils and Rocks

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2023, Volume 46 N. 1 elocation e2023008222

Abstract: En | Text: En | PDF: En

Abstract Soft ground improvement techniques have evolved substantially in Brazil in recent years. However, their application in soft and very soft clays requires a good understanding of the fundamentals of ground improvement techniques suited to the problem as well as the actual field behavior when implemented on a real scale. This paper describes some of the most widely used ground improvement techniques in the context of very soft clays in Brazil. The techniques described in the paper use prefabricated vertical drains (PVD) such as vacuum preloading; or combine PVD and rigid inclusion, such as CPR grouting; or are purely column-like elements such as piled embankments (including those executed with the deep mixing technique, DSM); or combine column-like elements with the drainage function, such as stone columns and geosynthetic encased columns; or use cementitious binders such as shallow soil mixing. The paper reference condition is a soft clay foundation in which no strengthening is implemented, such as, an embankment with basal reinforcement or soft clay with vertical prefabricated drains, or the use of vacuum preloading to speed up the consolidation rate. The applications of the ground improvement techniques are illustrated by case histories, numerical analyses, or physical models. Different types of measurements are used to evaluate the performance of each technique, including settlements, horizontal displacements, excess pore pressures, embankment applied stresses, stress concentration factors, and clay strength following the ground treatment. The settlement improvement factor β, the ratio between the settlements for untreated and treated conditions, is shown to be a suitable parameter to assess the degree of improvement imposed in the soft foundation by ranking the various methods in increased order of strengthening effect.

https://doi.org/10.28927/sr.2023.008222

13.

Exploring the frequency of a TP53 polyadenylation signal variant in tumor DNA from patients diagnosed with lung adenocarcinomas, sarcomas and uterine leiomyomas
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Vieira, Igor Araujo

; Viola, Guilherme Danielski

; Pezzi, Eduarda Heidrich

; Kowalski, Thayne Woycinck

; Fernandes, Bruna Vieira

; Andreis, Tiago Finger

; Bom, Natascha

; Sonnenstrahl, Giulianna

; Rocha, Yasminne Marinho de Araújo

; Corrêa, Bruno da Silveira

; Donatti, Luiza Mezzomo

; Sant’Anna, Gabriela dos Santos

; Corleta, Helena von Eye

; Brum, Ilma Simoni

; Rosset, Clévia

; Vianna, Fernanda Sales Luiz

; Macedo, Gabriel S.

; Palmero, Edenir Inez

; Ashton-Prolla, Patricia

Genetics and Molecular Biology

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2023, Volume 46 N. 3 elocation e20230133

Abstract: En | Text: En | PDF: En

Abstract The TP53 3’UTR variant rs78378222 A>C has been detected in different tumor types as a somatic alteration that reduces p53 expression through modification of polyadenylation and miRNA regulation. Its prevalence is not yet known in all tumors. Herein, we examine tumor tissue prevalence of rs7837822 in Brazilian cohorts of patients from south and southeast regions diagnosed with lung adenocarcinoma (LUAD, n=586), sarcoma (SARC, n=188) and uterine leiomyoma (ULM, n=41). The minor allele (C) was identified in heterozygosity in 6/586 LUAD tumors (prevalence = 1.02 %) and none of the SARC and ULM samples. Additionally, next generation sequencing analysis revealed that all variant-positive tumors (n=4) with sample availability had additional pathogenic or likely pathogenic somatic variants in the TP53 coding regions. Among them, 3/4 (75 %) had the same pathogenic or likely pathogenic sequence variant (allele frequency <0.05 in tumor DNA) namely c.751A>C (p.Ile251Leu). Our results indicate a low somatic prevalence of rs78378222 in LUAD, ULM and SARC tumors from Brazilian patients, which suggests that no further analysis of this variant in the specific studied regions of Brazil is warranted. However, these findings should not exclude tumor molecular testing of this TP53 3’UTR functional variant for different populations.

https://doi.org/10.1590/1678-4685-gmb-2023-0133

14.

Proximidade geográfica ainda importa para inovação? Considerações baseadas na interação universidade-empresa em contexto periférico
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Fernandes, Ana Cristina de Almeida

; Souza, Bruno Campello de

; Silva, Alexandre Stamford da

; Lima, João Policarpo Rodrigues

Revista Brasileira de Estudos Urbanos e Regionais

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2023, Volume 25 elocation e202310

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Interactions between universities and industry are essential for innovation systems, whereby the process is catalyzed by the proximity between these actors in different dimensions (cognitive, organizational, social, institutional and geographical). The present paper seeks to investigate the specific importance of geographical proximity for university-industry interactions during a specific moment in Brazil’s peripheral socioeconomic formation, with the construction of an institutional framework that proved favorable to peripheral innovation and the advancement of information and communication technologies that would dispense with co-location and face-to-face contact in collective learning processes. By applying multiple linear regression analysis and smallest space analysis (SSA) to a database obtained from an extensive survey, it was observed that, associated with the cognitive dimension, geographical proximity still prevails in interactions for innovation in peripheral contexts.

Resumo Interações entre universidades e empresas são essenciais para sistemas de inovação, com o processo catalisado pela proximidade entre esses atores em diferentes dimensões (cognitiva, organizacional, social, institucional e geográfica). O presente trabalho pretende promover a compreensão da importância da proximidade geográfica para interações universidade-empresa em um momento histórico específico da formação socioeconômica brasileira, quando se observavam a construção de um arcabouço institucional favorável à inovação periférica e o avanço das tecnologias de informação e comunicação que dispensariam a colocalização e o contato face a face em processos de aprendizagem coletiva. A aplicação de análises de Regressão Linear Múltipla e da Smallest Space Analysis (SSA) a uma base de dados obtida em 2008, resultante de uma survey extensiva, permitiu observar que, associada à dimensão cognitiva, a proximidade geográfica prevalece em interações para inovação em contextos periféricos.

https://doi.org/10.22296/2317-1529.rbeur.202310pt

15.

Ichthyofauna on the move: fish colonization and spread through the São Francisco Interbasin Water Transfer Project
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Silva, Augusto Luís Bentinho

; Galvão, Giancarlo Arraes

; Rocha, Aline Alves Ferreira da

; Gutierre, Silvia Maria Millan

; Santos, Geiza Rodrigues dos

; Costa, Bruno Dourado Fernandes da

; Pereira, Luiz Cezar Machado

; Nicola, Patricia Avello

Neotropical Ichthyology

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2023, Volume 21 N. 1 elocation e220016

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Projects on river basin integration are keen social-economical drivers in dry regions like the Brazilian semiarid, however, there are concerning ecological impacts implied in those projects. In a long-term analysis, ichthyofauna colonization and spread through the East Axis of the São Francisco River Integration Project (SFIP) was monitored to assess possible impacts on the receiving Paraíba River basin. The fish were collected semiannually (2012 to 2021) from 19 sites in the São Francisco (SF) and Paraíba (PB) basins. A total of 69 fish species were recorded, with distinct fish assemblages between SF (n = 50), PB (n = 35), and the SFIP artificial reservoirs (n = 25). The SFIP reservoirs were colonized by species from the donor basin (SF). In a pioneer finding, Anchoviella vaillanti was recorded for the first time in the receiving basin and it is in the process of establishment. The two SF species that reached PB through the SFIP canals (A. vaillanti and Moenkhausia costae) may be using their year-round reproduction and wide diet to successful spread and colonize the new environment. Since we detected species with potential to reach the receiving basin and became invasives, the implementation of barriers to contain their spread are recommended.

Resumo Projetos de integração de bacias hidrográficas são socialmente importantes em regiões como o semiárido brasileiro, porém há impactos ecológicos preocupantes implícitos nesses grandes projetos de infraestrutura. A colonização e dispersão da ictiofauna pelo Eixo Leste do Projeto de Integração do Rio São Francisco (PISF) foi monitorada para avaliar possíveis impactos na bacia receptora do rio Paraíba do Norte. Os peixes foram coletados semestralmente (2012 a 2021) em 19 locais das bacias do São Francisco (SF) e Paraíba (PB). Foram registradas 69 espécies de peixes, sendo 50 nos pontos do SF, 25 nos reservatórios artificiais ao longo do PISF e 35 nos pontos do PB. As assembleias de peixes das bacias do SF, PB e dos reservatórios do PISF foram significativamente distintas. Os reservatórios do PISF foram colonizados por espécies provenientes da bacia doadora (SF). Anchoviella vaillanti foi registrada pela primeira vez na bacia receptora do PB e está em processo de estabelecimento. As duas espécies do SF que chegaram ao PB pelos canais do PISF (A. vaillanti e Moenkhausia costae) apresentaram dieta e estratégias reprodutivas que permitem o sucesso na disseminação e colonização. Uma vez que foram detectadas espécies com potencial de atingir a bacia receptora, recomenda-se o monitoramento e manejo contínuos.

https://doi.org/10.1590/1982-0224-2022-0016

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