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Trabecular micro-bypass implant (iStent®) in a case of bilateral acute depigmentation of the iris
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Maestrini, Heloisa Andrade

; Maestrini, Angela Andrade

; Cenachi, Sarah Pereira de Freitas

; Massote, José Aloisio

; Lopes, Amanda Batista

; Fernandes, Thatiana Almeida Pereira

Arquivos Brasileiros de Oftalmologia

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2024, Volume 87 N. 3 elocation e2021-0239

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Relatamos um caso de despigmentação aguda bilateral da íris, no qual obtivemos adequado controle da pressão intraocular com o implante do iStent®, após resolução da fase aguda da doença. Paciente feminina, 62 anos, atendida com quadro agudo, bilateral e simultâneo de dor ocular, fotofobia, hipertensão ocular (34 mmHg), pigmentos circulantes na câmara anterior, áreas de despigmentação iriana e sinéquias posteriores. Havia recebido amoxicilina-clavulanato e moxifloxacina orais para pneumonia 2 meses antes. Suspeitando-se de despigmentação aguda bilateral da íris ou de etiologia viral, recebeu acetazolamida, aciclovir e prednisona orais, e colírios prednisolona, betaxolol, brimonidina, dorzolamida e atropina. O quadro se resolveu gradualmente em 4 meses, porém, após 1 ano, desenvolveu catarata bilateral e ainda usava 3 colírios hipotensores (pressão intraocular 16/18 mmHg). A cirurgia combinada de catarata-iStent® foi realizada em ambos os olhos. Um ano depois, a pressão intraocular mantinha-se 11/12 mmHg, sem medicação. O iStent® foi seguro e eficaz no controle deste glaucoma secundário.

ABSTRACT We report a case of bilateral acute depigmentation of the iris in which satisfactory intraocular pressure control was obtained after resolution of the acute disease with a trabecular implant (iStent®). A 62-year-old woman presented with bilateral simultaneous acute eye pain, photophobia, increased intraocular pressure (34 mmHg), circulating pigment in the anterior chamber, areas of depigmentation in the iris, and posterior synechiae. She had received oral amoxicillin-clavulanate and moxifloxacin for pneumonia 2 months previously. Bilateral acute depigmentation of the iris was suspected as well as a viral etiology. She received oral acetazolamide, aciclovir, and prednisone, besides topical prednisolone, betaxolol, brimonidine, dorzolamide, and atropine. The disease gradually resolved in 4 months but, after 1 year, she developed bilateral cataracts, and still needed three drugs for intraocular pressure control (16/18 mmHg). Cataract-iStent® combined surgery was performed in both eyes. One year after surgery, intraocular pressure was 11/12 mmHg, without medication. iStent® was safe and effective on this secondary glaucoma.

https://doi.org/10.5935/0004-2749.2021-0239

EXPLORATORY ANALYSIS OF DIETARY PATTERNS OF PATIENTS WITH GASTRIC ADENOCARCINOMA: A CASE-CONTROL STUDY IN CENTRAL BRAZIL
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SANTIAGO, Silvana Barbosa

; SOUSA, Gabriela Rodrigues de

; RAMOS, Amanda Ferreira Paes Landim

; FERNANDES, Gisele Aparecida

; CURADO, Maria Paula

; BARBOSA, Mônica Santiago

Arquivos de Gastroenterologia

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nov 2023, Volume 60 N. 4 Pages 419 - 430

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Contexto: A dieta é um dos fatores de risco modificáveis mais importante para a incidência de câncer gástrico. Objetivo: Realizar uma análise exploratória sobre os padrões alimentares de indivíduos com adenocarcinoma gástrico (AdG) na região Brasil central. Métodos: Este é um estudo de caso-controle realizado no período de abril de 2019 a julho de 2022, em três centros de referência para o tratamento para câncer em Goiânia-GO. Os casos foram pacientes diagnosticados com AdG, o controle 1 pacientes dispépticos submetidos a endoscopia digestiva alta e o controle 2 pacientes sem queixas gástricas. Nos três grupos foram recrutados pacientes de 18 a 75 anos e de ambos os sexos. Para avaliar o consumo alimentar foi utilizado um Questionário de Frequência Alimentar validado para a população brasileira. Os padrões alimentares foram identificados por Análise Fatorial Exploratória (AFE), utilizando a análise de componentes principais como método de extração, seguida pela rotação Varimax. Resultados: Os valores de comunalidade na AFE para os alimentos/grupos alimentares consumidos pelos casos e controles ficaram acima de 0,30 para todas as variáveis. A variância explicada pelo modelo foi de 66,7%, para casos, 60,3% para o controle 1 e 59,7% para o controle 2. Foram identificados três padrões alimentares nos casos, controle 1 e controle 2 que explicaram 34,87%, 35,41% e 33,25% respectivamente da variância total. O primeiro padrão (“saudável”) foi caracterizado pelo consumo de vegetais, frutas, carne e queijos; o segundo (“não saudável”) por embutidos, pizzas, snacks, ketchup, bebidas doces e macarrão instantâneo e o terceiro (“prudente”) arroz, feijão, carnes e peixes fritos e massas. Conclusão: Esse estudo identificou três padrões alimentares entre os pacientes com AdG e os controles na região Brasil central. De acordo com os padrões identificados, será possível estabelecer uma relação entre a dieta e outras medidas epidemiológicas destinadas à prevenção do câncer gástrico.

ABSTRACT Background: Diet is one of the most important modifiable risk factors for the incidence of gastric cancer. Objective: To carry out an exploratory analysis on the dietary patterns of individuals with gastric adenocarcinoma (AdG) in the Central Brazil region. Methods: This is a case-control study carried out from April 2019 to July 2022, in three reference centers for cancer treatment in Goiânia-GO. The cases were patients diagnosed with AdG, the control 1 dyspeptic patients submitted to upper digestive endoscopy and the control 2 patients without gastric complaints. In the three groups, patients aged 18 to 75 years and of both sexes were recruited. To assess food consumption, a Food Frequency Questionnaire validated for the Brazilian population was used. Dietary patterns were identified by Exploratory Factor Analysis (EFA), using principal component analysis as the extraction method, followed by Varimax rotation. Results: The commonality values in the EFA for the foods/food groups consumed by the cases and controls were above 0.30 for all variables. The variance explained by the model was 66.7% for cases, 60.3% for control 1 and 59.7% for control 2. Three eating patterns were identified in cases, control 1 and control 2 that explained 34, 87%, 35.41% and 33.25% respectively of the total variance. The first pattern (“healthy”) was characterized by the consumption of vegetables, fruits, meat and cheese; the second (“unhealthy”) for sausages, pizzas, snacks, ketchup, sweet drinks and instant noodles and the third (“prudent”) rice, beans, meat and fried fish and pasta. Conclusion: This study identified three dietary patterns among patients with AdG and controls in the Central Brazil region. According to the identified patterns, it will be possible to establish a relationship between diet and other epidemiological measures aimed at the prevention of gastric cancer.

https://doi.org/10.1590/s0004-2803.230402023-67

EVALUATION OF THE ANTEROLATERAL LIGAMENT OF THE KNEE IN MAGNETIC RESONANCE MRI: CASE SERIES
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GUERREIRO, JOÃO PAULO FERNANDES

; MANINI, AMANDA BREVILHERI BENASSI

; CAMPANHÃ, DAVID BONINI VIEIRA

; ZENDRINI, GIOVANA ORTIZ

; BIGNARDI, PAULO ROBERTO

; DANIELI, MARCUS VINICIUS

Acta Ortopédica Brasileira

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2023, Volume 31 N. 2 elocation e264848

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: To evaluate the citation of the ligament in the magnetic resonance imaging (MRI) reports and confirm its presence and injury in the images of exams performed in the acute phase retrospectively. Methods: In total, 103 patients who underwent anterior cruciate ligament (ACL) reconstruction in 2019 were included. The images were reanalyzed by two radiologists. Results: In the first analysis, only one report mentioned the anterolateral ligament (ALL) and its injury (0.97%). On reanalysis, ALL was visualized in almost all cases (95% and 97%). An injury was found in 53 (51.5%) cases by radiologist A and in 56 (54.4%) cases by radiologist B. The injury was diagnosed by both in 39 (37.9%) cases (p < 0.0001). Radiologists disagreed regarding the injury (Kappa = 0.411). Conclusion: The reports failed to describe the ligament and diagnose a significant number of injuries. The analysis of conventional resonance images still presents divergences in the diagnosis of ALL injury associated with the ACL among radiologists. Level of Evidence IV, Case Series.

RESUMO Objetivo: Avaliar, de forma retrospectiva, a citação do ligamento anterolateral (LAL) em laudos de ressonância magnética (RM) e confirmar sua presença e lesão nas imagens de exames feitos na fase aguda. Métodos: Foram incluídos 103 pacientes submetidos à reconstrução do ligamento cruzado anterior (LCA) em 2019, cujas imagens foram reanalisadas por dois radiologistas. Resultados: Em primeira análise, apenas um laudo citava o LAL e sua lesão (0,97%); enquanto na reanálise, o LAL foi visualizado em quase todos os casos (95% pelo radiologista A e 97% pelo radiologista B). Foi encontrada lesão em 53 (51,5%) casos pelo radiologista A e 56 (54,4%) pelo radiologista B. Lesão foi diagnosticada por ambos em 39 (37,9%) casos (p < 0,0001). Houve divergência entre os radiologistas com relação à lesão (KappaL = 0,411). Conclusão: Os laudos deixaram de descrever o ligamento e diagnosticar um número significativo de lesões. A análise das imagens convencionais de ressonância ainda gera divergências no diagnóstico da lesão do LAL associada ao LCA entre os radiologistas. Nível de Evidência IV, Série de Casos.

https://doi.org/10.1590/1413-785220233102e264848

How do relocation time and length of storage after relocation affect fermentation and nutritive value of corn silage?
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Santos, Rosana Ingrid Ribeiro dos

; Mendonça, Rita de Cássia Almeida de

; Queiroz, Amanda Caroliny Marques de

; Bernardes, Thiago Fernandes

; Domingues, Felipe Nogueira

; Faturi, Cristian

; Silva, Thiago Carvalho da

; Rêgo, Aníbal Coutinho do

Revista Brasileira de Zootecnia

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2023, Volume 52 elocation e20220059

Abstract: En | Text: En | PDF: En

ABSTRACT This study aimed to determine the effects of relocation time (RT; Experiment 1) and storage time after relocation (ST; Experiment 2) on microbial population, fermentative characteristics, and chemical composition of corn silage. In experiment 1, corn silage was stored for 30 d, subjected to different RT (0–60 h), and stored again for 30 d. Thirty experimental silos were used in a completely randomized design, with three replicates per treatment. In experiment 2, after 150 d of ensiling, silage was removed from a bunker silo, exposed to air for 9 h, relocated to experimental silos, and stored for periods ranging from 0 to 128 d. Twenty-eight experimental silos were used in a completely randomized design, with four replicates per treatment. Relocation time had no effect on fungi counts and concentrations of lactic and propionic acids in corn silage but resulted in a significant increase in dry matter content. In experiment 2, dry matter recovery and concentration of non-fiber carbohydrates decreased in corn silage stored for more than 32 d after relocation. Exposure of corn silage to air during relocation for up to 60 h followed by 30 d of storage did not compromise the fermentation profile or nutritive value of the silage. Increased storage time of relocated corn silage (up to 128 d) consistently decreases its nutritional value. The storage period seems to have an increased impact on nutrient loss in relocated silage than the relocation period.

https://doi.org/10.37496/rbz5220220059

Sporotrichosis: In silico design of new molecular markers for the Sporothrix genus
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Fernandes, Blenda

; Santrer, Emanoelle Fernandes Rutren La

; Figueiredo, Sônia Maria de

; Rocha-Silva, Fabiana

; Assunção, Cláudia Barbosa

; Abreu, Amanda Gabrielle

; Santiago, Iara Furtado

; Johann, Susana

; Caligiorne, Rachel Basques

Revista da Sociedade Brasileira de Medicina Tropical

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2023, Volume 56 elocation e0217-2022

Abstract: En | Text: En | PDF: En

ABSTRACT Background: Sporotrichosis, a cosmopolitan mycosis caused by dimorphic fungi of the Sporothrix complex, affects humans and animals. This study aimed to develop new molecular markers for Sporothrix genome detection in biological samples using PCR. Methods: A specific region of DNA sequences from the Sporothrix genus, publicly available in GenBank, was chosen for primer design. After testing the in silico specificity of these primers, in vitro specificity was evaluated using the PCR technique. Results: Three specific primers with 100% specificity for the Sporothrix genus were generated. Conclusions: PCR using the designed primers can be used to develop molecular diagnostics for sporotrichosis.

https://doi.org/10.1590/0037-8682-0217-2022

Lesão Miocárdica e Prognóstico em Pacientes Hospitalizados com COVID-19 no Brasil: Resultados do Registro Nacional de COVID-19
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Barbosa, Hannah Cardoso

; Martins, Maria Auxiliadora Parreiras

; Jesus, Jordana Cristina de

; Meira, Karina Cardoso

; Passaglia, Luiz Guilherme

; Sacioto, Manuela Furtado

; Bezerra, Adriana Falangola Benjamin

; Schwarzbold, Alexandre Vargas

; Maurílio, Amanda de Oliveira

; Farace, Barbara Lopes

; Silva, Carla Thais Cândida Alves da

; Cimini, Christiane Corrêa Rodrigues

; Silveira, Daniel Vitorio

; Carazai, Daniela do Reis

; Ponce, Daniela

; Costa, Emanuel Victor Alves

; Manenti, Euler Roberto Fernandes

; Cenci, Evelin Paola de Almeida

; Bartolazzi, Frederico

; Madeira, Glícia Cristina de Castro

; Nascimento, Guilherme Fagundes

; Velloso, Isabela Vasconcellos Pires

; Batista, Joanna d’Arc Lyra

; Morais, Júlia Drumond Parreiras de

; Carvalho, Juliana da Silva Nogueira

; Ruschel, Karen Brasil

; Martins, Karina Paula Medeiros Prado

; Zandoná, Liege Barella

; Menezes, Luanna Silva Monteiro

; Kopittke, Luciane

; Castro, Luís César de

; Nasi, Luiz Antônio

; Floriani, Maiara Anschau

; Souza, Maíra Dias

; Carneiro, Marcelo

; Bicalho, Maria Aparecida Camargos

; Lima, Maria Clara Pontello Barbosa

; Godoy, Mariana Frizzo de

; Guimarães-Júnior, Milton Henriques

; Mendes, Paulo Mascarenhas

; Delfino-Pereira, Polianna

; Ribeiro, Raquel Jaqueline Eder

; Finger, Renan Goulart

; Menezes, Rochele Mosmann

; Francisco, Saionara Cristina

; Araújo, Silvia Ferreira

; Oliveira, Talita Fischer

; Oliveira, Thainara Conceição de

; Polanczyk, Carisi Anne

; Marcolino, Milena Soriano

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 2 elocation e20220151

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento As complicações cardiovasculares da COVID-19 são aspectos importantes da patogênese e do prognóstico da doença. Evidências do papel prognóstico da troponina e da lesão miocárdica em pacientes hospitalizados com COVID-19 na América Latina são ainda escassos. Objetivos Avaliar a lesão miocárdica como preditor independente de mortalidade hospitalar e suporte ventilatório mecânico em pacientes hospitalizados, do registro brasileiro de COVID-19. Métodos Este estudo coorte é um subestudo do registro brasileiro de COVID-19, conduzido em 31 hospitais brasileiros de 17 cidades, de março a setembro de 2020. Os desfechos primários incluíram mortalidade hospitalar e suporte ventilatório mecânico invasivo. Os modelos para os desfechos primários foram estimados por regressão de Poisson com variância robusta, com significância estatística de p<0,05. Resultados Dos 2925 pacientes [idade mediana de 60 anos (48-71), 57,1%], 27,3% apresentaram lesão miocárdica. A proporção de pacientes com comorbidades foi maior nos pacientes com lesão miocárdica [mediana 2 (1-2) vs. 1 (0-20)]. Os pacientes com lesão miocárdica apresentaram maiores valores medianos de peptídeo natriurético cerebral, lactato desidrogenase, creatina fosfoquinase, N-terminal do pró-peptídeo natriurético tipo B e proteína C reativa em comparação a pacientes sem lesão miocárdica. Como fatores independentes, proteína C reativa e contagem de plaquetas foram relacionados com o risco de morte, e neutrófilos e contagem de plaquetas foram relacionados ao risco de suporte ventilatório mecânico invasivo. Os pacientes com níveis elevados de troponina apresentaram um maior risco de morte (RR 2,03, IC95% 1,60-2,58) e suporte ventilatório mecânico (RR 1,87;IC95% 1,57-2,23), em comparação àqueles com níveis de troponina normais. Conclusão Lesão cardíaca foi um preditor independente de mortalidade hospitalar e necessidade de suporte ventilatório mecânico em pacientes hospitalizados com COVID-19.

Abstract Background Cardiovascular complications of COVID-19 are important aspects of the disease’s pathogenesis and prognosis. Evidence on the prognostic role of troponin and myocardial injury in Latin American hospitalized COVID-19 patients is still scarce. Objectives To evaluate myocardial injury as independent predictor of in-hospital mortality and invasive mechanical ventilation support in hospitalized patients, from the Brazilian COVID-19 Registry. Methods This cohort study is a substudy of the Brazilian COVID-19 Registry, conducted in 31 Brazilian hospitals of 17 cities, March-September 2020. Primary outcomes included in-hospital mortality and invasive mechanical ventilation support. Models for the primary outcomes were estimated by Poisson regression with robust variance, with statistical significance of p<0.05. Results Of 2,925 patients (median age of 60 years [48-71], 57.1% men), 27.3% presented myocardial injury. The proportion of patients with comorbidities was higher among patients with cardiac injury (median 2 [1-2] vs. 1 [0-2]). Patients with myocardial injury had higher median levels of brain natriuretic peptide, lactate dehydrogenase, creatine phosphokinase, N-terminal pro-brain natriuretic peptide, and C-reactive protein than patients without myocardial injury. As independent predictors, C-reactive protein and platelet counts were related to the risk of death, and neutrophils and platelet counts were related to the risk of invasive mechanical ventilation support. Patients with high troponin levels presented a higher risk of death (RR 2.03, 95% CI 1.60-2.58) and invasive mechanical ventilation support (RR 1.87, 95% CI 1.57-2.23), when compared to those with normal troponin levels. Conclusion Cardiac injury was an independent predictor of in-hospital mortality and the need for invasive mechanical ventilation support in hospitalized COVID-19 patients.

https://doi.org/10.36660/abc.20220151

Temporal trend of mortality from infectious respiratory diseases in childhood in Minas Gerais, Brazil, 2000-2020
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Moura, Davi Nilson Aguiar e

; Silva, Fillipe Reis

; Assumpção, David Morosini de

; Reis, Nícolas Emanuel Oliveira

; Cunha, Isabela Fernandes Coelho

; Silva, Amanda Priscila de Santana Cabral

; Alves, Waneska Alexandra

Epidemiologia e Serviços de Saúde

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2023, Volume 32 N. 3 elocation e2022796

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

RESUMO Objetivo: analisar as tendências temporais de mortalidade por doença respiratória infecciosa em crianças com até 12 anos incompletos, Minas Gerais, Brasil, de 2000 a 2020. Métodos: estudo ecológico dos óbitos por doença respiratória infecciosa em crianças com até 12 anos incompletos, registrados no Sistema de Informações sobre Mortalidade; as variáveis estudadas foram o agente etiológico, o sítio anatômico da infecção e o sexo; as tendências foram analisadas por regressão joinpoint. Resultados: dos 4.688 óbitos registrados, 84,5% tiveram agente etiológico não especificado e 88% decorreram de infecções nas vias aéreas inferiores; observou-se tendência decrescente nos óbitos e na proporção de óbitos provocados por agente etiológico não especificado; em 2020, houve incremento do número de óbitos de etiologia viral e de acometimento sistêmico. Conclusão: além da alteração no perfil etiológico, notou-se redução da mortalidade por doenças respiratórias infecciosas em crianças - mesmo em 2020, ano de pandemia de covid-19.

RESUMEN Objetivo: analizar las tendencias temporales de mortalidad por enfermedades respiratorias infecciosas en niños de hasta 12 años incompletos en Minas Gerais, Brasil, de 2000 a 2020. Métodos: estudio ecológico con datos de muertes en niños de hasta 12 años incompletos, registradas en el Sistema de Información de Mortalidad; las variables estudiadas fueron: agente etiológico, sitio anatómico de infección y género; las tendencias se analizaron mediante la regresión jointpoint. Resultados: de las 4.688 muertes registradas, el 84,5% tenía un agente etiológico de la enfermedad no especificado y el 88% se debía a infecciones de las vías respiratorias bajas; hubo una tendencia decreciente en las muertes y en la proporción de muertes por agente no especificado; en 2020, hubo un aumento en el número de muertes de etiología viral y acometimiento sistémico. Conclusión: además del cambio en el perfil etiológico, hubo una reducción de la mortalidad por enfermedades respiratorias infecciosas en niños, incluso considerando 2020, año de la pandemia de Covid-19.

ABSTRACT Objective: to analyze temporal trends in mortality due to infectious respiratory disease in children under 12 years old in Minas Gerais, Brazil, from 2000 to 2020. Methods: this was an ecological study using data on infectious respiratory disease in children under 12 years old registered on the Mortality Information System; the variables studied were etiological agent, anatomical site of infection and sex; trends were analyzed by joinpoint regression. Results: of the 4,688 registered deaths, the etiological agent of the disease was unspecified for 84.5% of them, and 88% were due to lower respiratory tract infections; there was a decreasing trend in deaths and in the proportion of deaths due to unspecified etiologic agents; in 2020, there was an increase in deaths with viral etiology and systemic involvement. Conclusion: in addition to the change in the etiologic profile, there was a reduction in mortality due to infectious respiratory diseases in children, even considering 2020, the year of the COVID-19 pandemic.

https://doi.org/10.1590/s2237-96222023000300006.en

Association of Oral Health-Related Quality of Life with the Longevity of ART-Restorations in Children
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Salas-Huamani, Juana Rosmeri

; Sousa, Karina Guedes de

; Gomes, Gabriellen Fernanda

; Silva, Amanda Fernandes

; Silva, Thalita Lucas Brum Moreira da

; Carvalho, Fabíola Galbiatti de

; Rocha, Renata Andrea Salvitti de Sá

; Barbosa, Taís de Souza

Pesquisa Brasileira em Odontopediatria e Clínica Integrada

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2023, Volume 23 elocation e220056

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: To evaluate the association of oral health-related quality of life (OHRQoL) with the longevity of ART-restorations in children after 18 months. Material and Methods: A longitudinal clinical study with 62 six- to seven-year-old children, both genders, 31 of whom underwent four weeks of oral health education strategy (OHES) followed by ART (GOHES+ART) and the others only ART (GART). The Brazilian short-version of the Child Perceptions Questionnaire (16-CPQ8-10) was used to evaluate the OHRQoL and the perception of change in oral health was assessed by a single question. Data was analyzed using Mann-Whitney, Wilcoxon and Friedman's tests. Results: After 18 months, GOHES+ART reported a greater impairment on OHRQoL, mainly in oral symptoms domain (p<0.05). In this period, greater impairment of oral symptoms was reported in children with failed restorations and with treatment considered to have a minor failure (p<0.05). In inter-group analysis, the GOHES+ART, with 2 to 4 restorations, Class I, of small size, located in the upper arch and with a smaller failure, reported more oral symptoms than the GART. Conclusion: In the long-term, children submitted to OHES followed by ART reported more oral symptoms. Factors such as number, class, size and location of the restorations need to be considered for the implementation of an efficient and effective oral health program, as well as for greater longevity of ART-restorations.

https://doi.org/10.1590/pboci.2023.068

Lacticaseibacillus casei decrease long-chain fatty acids and most substances in an experimental model of intestinal mucositis
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Barbosa, Stphannie Jamyla de Araújo

; Silva, Amanda Silveira da

; Oliveira, Maisie Mitchele Barbosa

; Ribeiro, Susana Barbosa

; Medeiros, Caroline Addison Carvalho Xavier de

; Ferreira, Leandro de Santis

; Pinheiro, Francisco Ayrton Senna Domingos

; Sousa Junior, Francisco Canindé de

; Martins, Agnes Andrade

; Araújo Júnior, Raimundo Fernandes de

; Garcia, Vinícius Barreto

; Araújo, Aurigena Antunes de

Acta Cirúrgica Brasileira

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2023, Volume 38 elocation e386723

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To evaluate the long-chain fatty acid and major compounds levels in the feces after prophylactic oral use of Lacticaseibacillus casei in an experimental model of intestinal mucositis. Methods: Fifteen Swiss mice were randomly divided into three groups (n=5/group): The negative or positive control groups (n = 5) received saline orally for 18 days and an the intraperitoneal (i.p.) of saline or 5 Fluorouracil (450 mg/kg) in 15th day, respectability. L. casei group received oral concentration of L. casei (1x109 CFU/mL) for 18 days, the i.p. injection of 5-fluorouracil (450 mg/kg) in 15th days. Tissue samples from colon and each small intestine segment were collected for histopathological analysis. Stool samples were collected. Fecal composition of long-chain fatty acids and sterols were analysed by gas chromatography-mass spectrometry on the 15th and the 18th day. Results: The mucosa layer of all small intestine segments of animals from L. casei showed well preserved epithelium and glands, without necrosis signs, but Goblet cells number decreased. Several long-chain fatty acids and sterols have been identified before and after in the groups. L. casei administration after 5-FU treatment reduced concentrations of linoleic acid (18:2) (p < 0.001) and oleic acid (18:1) (p < 0.001) in feces. Conclusions: L. casei prevented the mucosal damage associated with 5-FU-induced intestinal mucositis reduced long-chain fatty acid levels in the feces.

https://doi.org/10.1590/acb386723

10.

Data-Driven Decision Making (DDDM) sob a perspectiva da Integração Sensorial de Ayres®
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Rolim, Amanda Fernandes

; Liider, Loysi Crystine Marchi

; Omairi, Claudia

Cadernos Brasileiros de Terapia Ocupacional

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2023, Volume 31 elocation e3541

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução O método de Integração Sensorial de Ayres® (ISA) vem se destacando dentro da terapia ocupacional ao implementar sua prática baseada em evidências e, por este motivo, tem tido grande notoriedade no mundo e no Brasil. Para garantir a qualidade dos serviços prestados, os programas de treinamento em Integração Sensorial de Ayres® seguem alguns padrões mínimos, incluindo o uso da Medida de Fidelidade© e a interpretação de dados da avaliação para informar o raciocínio clínico, podendo ser realizada por meio do Data-Driven Decision Making (DDDM). Objetivo Visto que o DDDM é um instrumento ainda pouco abordado no Brasil, propõe-se apresentar suas principais contribuições para o raciocínio clínico e profissional de terapeutas ocupacionais e para a geração de evidências. Método Trata-se de uma revisão integrativa e narrativa de literatura com abordagem quali-quantitativa, sendo o período de amostra os anos de 2012 a março de 2022. Entre os 22 títulos encontrados, foram incluídos 13 artigos científicos nesta revisão. Resultados O DDDM demonstrou ser um instrumento seguro e viável para utilização na prática clínica em ISA®, havendo diversas contribuições, como: prática centrada no cliente, a geração de hipóteses, a preparação e condução de atividades e intervenções personalizadas, elaboração de metas apropriadas para cada caso e quantificação da eficácia da intervenção. Conclusão É um instrumento que fornece suporte à prática baseada em evidências, bem como orienta o raciocínio clínico de terapeutas ocupacionais por meio do foco na utilização de tomada de decisão baseada em dados.

Abstract Introduction The Ayres Sensory Integration® (ASI) method has been standing out within Occupational Therapy when implementing its evidence-based practice and, for this reason, it has had great notoriety in Brazil and in the world. To ensure the quality of the services provided, Ayres Sensory Integration® training programs follow some minimum standards, including the use of the Fidelity Measure© and the interpretation of evaluation data to inform clinical reasoning, which can be carried out through the Data-Driven Decision Making (DDDM). Objective Since DDDM is a tool that is still little discussed in Brazil, it is proposed to present its main contributions to the clinical and professional reasoning of occupational therapists and to the generation of evidence. Method This is an integrative and narrative literature review with a quali-quantitative approach, the sample period being the years from 2012 to March 2022. Among the 22 titles found, 13 scientific articles were included in this Review. Results DDDM proved to be a safe and viable tool for use in clinical practice in ASI®, with several contributions such as: client-centered practice, generation of hypotheses, development of personalized activities and intervention, elaboration of appropriate goals for each case and quantification of intervention effectiveness. Conclusion It is a tool that supports evidence-based practice as well as guides the clinical reasoning of occupational therapists through a focus on the use of data-based decision making.

https://doi.org/10.1590/2526-8910.ctore271635411

11.

Saúde mental infantojuvenil na atenção básica à saúde: perspectivas e desafios
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Fernandes, Amanda

; Cid, Maria Fernanda

; Matsukura, Thelma

Psicologia, Saúde & Doenças

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dec 2022, Volume 23 N. 3 Pages 710 - 722

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract The public policies of mental health of children and adolescents in Brazil affirmed the importance of caring for children and adolescents in psychological distress in different equipment of the network, with a focus on Primary Health Care (ABS). Thus, the objective of the present study was to identify how care has been provided to children and adolescents in psychological distress in ABS, in order to reveal the challenges, perspectives and powers at this level of health care. This is a quantitative-qualitative, exploratory and descriptive research, with the participation of 53 managers from the ABS Health Units, from seven municipalities in the State of São Paulo - Brazil. Three instruments were used for data collection: a) way of identifying and characterizing the participants; b) form for identification and characterization of Health Units and c) general questionnaire, available to participants on an online platform. Quantitative data were analyzed descriptively and qualitative data through categorical analysis. The main results indicate that the care actions offered to this population in the ABS are strongly focused on health problems, as in the actions and programs aimed at vaccination, medical consultations and childcare. In addition, it was identified that, when they exist, child mental health care actions are mainly directed at specialists and referrals to specialized equipment. It is argued that there is much to be done in terms of care for children and adolescents in psychological distress in ABS, in the perspective of deinstitutionalization and psychosocial care.

Resumo As políticas públicas de saúde mental infantojuvenil no Brasil tem afirmado a importância do cuidado a crianças e adolescentes em sofrimento psíquico em diferentes equipamentos da rede, com centralidade na Atenção Básica à Saúde (ABS). Assim, o objetivo do presente estudo foi identificar como tem se dado o cuidado a crianças e adolescentes em sofrimento psíquico na ABS, de forma a revelar os desafios, perspectivas e potências neste nível de atenção à saúde. Trata-se de uma pesquisa quantiqualitativa, exploratória e descritiva, que contou com a participação de 53 gestores de Unidades de Saúde da ABS, de sete municípios do Estado de São Paulo - Brasil. Foram utilizados três instrumentos para coleta de dados: a) formulário de identificação e caracterização dos participantes; b) formulário de identificação e caracterização das Unidades de Saúde e c) questionário geral, que foram disponibilizados para os participantes em uma plataforma online. Os dados quantitativos foram analisados descritivamente e os dados qualitativos por meio da análise categorial. Os principais resultados apontam que as ações de cuidado oferecidas a esta população na ABS estão fortemente voltadas aos problemas de saúde, como nas ações e programas dirigidos a vacinação, consultas médicas e puericultura. Além disso, identificou-se que quando existentes, as ações de cuidado em saúde mental infantojuvenil são majoritariamente voltadas aos especialistas e aos encaminhamentos aos equipamentos especializados. Discute-se que há muito que se avançar no que se refere ao cuidado às crianças e adolescentes em sofrimento psíquico na ABS, na perspectiva da desinstitucionalização e da atenção psicossocial.

https://doi.org/10.15309/22psd230310

12.

Precificação, estratégias e decisões empreendedoras: market fit e análise da concorrência no caso Sabor Anthigo
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Calvosa, Marcello Vinicius Doria

; Queiroz, Adylson Rhander dos Reis R. de

; Fernandes, Amanda Leticia M.

; Ferreira, Marcos

Cadernos EBAPE.BR

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oct 2022, Volume 20 N. 5 Pages 750 - 768

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo O presente caso de ensino retrata a realidade de uma pequena empresa longeva - o Restaurante e Pizzaria Sabor Anthigo - e tem por objetivo contextualizar dificuldades reais apresentadas por um empreendedor e confrontadas com estatísticas do setor, como mudanças ambientais, culturais, econômicas, demográficas e sociais experimentadas, alinhadas às teorias de marketing usadas em sala de aula. Os dados do caso de ensino foram coletados de 2 entrevistas direcionadas ao empreendedor e de documentos fornecidos por ele, além de ter sido feita uma pesquisa em estabelecimentos da região e em órgãos de fomento ao empreendedorismo. Optou-se por inserir, ao longo da história de vida e empreendedora do protagonista, Melquisedec Bahia, proposições práticas, dúvidas e possíveis objeções comerciais vivenciadas por gestores e estudantes de Administração e áreas afins, de graduação ou pós-graduação. O protagonista apresenta ansiedades gestoras/empreendedoras e indagações: como precificar corretamente produtos e serviços, segmentar o público-alvo, enfrentar a sazonalidade, identificar a concorrência e ajustar o negócio? A pesquisa tenta responder à seguinte pergunta: como estabelecer um fit de negócio interessante, viável, que comunique valor para os clientes e siga uma estratégia que proporcione estabilidade e sucesso ao empreendimento? Essa metodologia ativa buscará estimular a conexão entre desafios profissionais e a realidade do participante, a fim de desenvolver a dramatização profissional.

Abstract This teaching case portrays the reality of a long-lived small company - the Restaurant e Pizzaria Sabor Anthigo. It aimed to contextualize real difficulties presented by an entrepreneur, confronted with sector statistics, environmental, cultural, economic, demographic, and social changes experienced by the enterprise, in line with marketing theories used in classrooms. The data used in the teaching case were collected in two interviews aimed at the entrepreneur and in documents provided by him, in addition to research in establishments in the region and agencies that promote entrepreneurship. It was decided to insert throughout the life and entrepreneurial history of the protagonist, Melquisedec Bahia, practical propositions, doubts, and possible commercial objections experienced by managers and adminisitration students (and related areas), undergraduate or graduate students. The protagonist presents managerial/entrepreneurial anxieties and questions, such as: correctly pricing products and services; segment his target audience; face seasonality; identify the competition; adjust his business. The research question was: can you establish an interesting, viable business fit that communicates value to a certain audience and follows a strategy that provides stability and success for the enterprise? This active methodology encourages the connection between professional challenges and the participant’s reality to develop professional dramatization.

Resumen El presente caso de enseñanza retrata la realidad de una pequeña empresa longeva - el Restaurante e Pizzería Sabor Anthigo ‒ y tiene como objetivo contextualizar las dificultades reales presentadas por un emprendedor, frente a las estadísticas del sector, como cambios ambientales culturales, económicos, demográficos y sociales que vive la empresa, alineadas con las teorías de marketing presentes utilizadas en las aulas. Los datos del caso docente fueron recolectados en dos entrevistas dirigidas al emprendedor y en documentos proporcionados por él, además de investigaciones en establecimientos de la región y agencias que promueven el emprendimiento. Se decidió introducir a lo largo de la vida e historia emprendedora del protagonista, Melquisedec Bahía, propuestas prácticas, dudas y posibles objeciones comerciales vividas por gestores y estudiantes de Administración (y áreas afines), de graduación o posgrado. El protagonista presenta inquietudes y cuestiones gerenciales/empresariales, tales como: cómo fijar correctamente el precio de productos y servicios; segmentar su público objetivo; afrontar la estacionalidad; identificar la competencia y ajustar su negocio La cuestión investigada fue: cómo establecer un fit de negocio interesante y viable que pueda agregar valor a un determinado público y siga una estrategia que proporcione estabilidad y éxito a la empresa. Esta metodología activa buscará fomentar la conexión entre los desafíos profesionales y la realidad del participante para desarrollar la dramatización profesional.

https://doi.org/10.1590/1679-395120210146

13.

Postoperative analgesia efficacy of erector spinae plane block in patients submitted to cardiac surgery: randomized clinical trial
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Silva, Larissa Martins

; Brandão, Amanda Jiran Ferreira Marcos

; Godoy, Jhonson Tizzo

; Leão, Wirleyde Mattos

; Freitas, Juliana Faria de

; Fernandes, Magda Lourenço

Brazilian Journal of Anesthesiology

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oct 2022, Volume 72 N. 5 Pages 678 - 680

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.bjane.2022.06.006

14.

Do simple and quick functional tests reflect a more comprehensive test or physical activity in daily life in healthy young subjects?
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Oliveira, Joice Mara de

; Quirino, Jéssica Amanda de Oliveira

; Correia, Natielly Soares

; Santana, André Vinícius

; Rugila, Diery Fernandes

; Furlanetto, Karina Couto

Fisioterapia e Pesquisa

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aug 2022, Volume 29 N. 2 Pages 121 - 127

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Considerando o amplo uso de testes funcionais e que avaliações mais rápidas e simples são preferíveis, o objetivo deste estudo foi verificar a associação entre cinco protocolos de testes funcionais, a saber, timed up and go [TUG], 4-meter gait speed [4MGS] and sit to stand [STS] in 5-repetitions [STS5rep], 30-seconds [STS30sec] and 1-minute [STS1min] protocols e o teste de caminhada de 6 minutos (TC6min), bem como com a atividade física na vida diária (AFVD) em jovens saudáveis. Neste estudo transversal, a AFVD foi quantificada por um pedômetro validado para contagem de passos, e a média de sete dias consecutivos durante o tempo acordado foi considerada. A capacidade funcional foi avaliada pelo TUG, 4MGS, STS5rep, STS30sec, STS1min e TC6min. 79 pessoas sem comprometimento pulmonar foram incluídas (49% homens, idade média de 28 anos). O desempenho nos testes funcionais correlacionou-se com o TC6min (0,23< r <0,56; p<0,05 para todos) e o TUG apresentou a melhor associação (R²=0,34). Entretanto, os testes funcionais simples não se correlacionaram com a AFVD (0,03<r<0,13; p>0,05 para todos). Os testes funcionais de curta duração foram fracos, moderadamente relacionados ao TC6min em jovens saudáveis. O TUG apresentou a melhor associação e explicou até 34% do TC6min; no entanto, este não pode ser substituído por nenhum dos testes funcionais simples. Por fim, a capacidade funcional não se relacionou com a atividade física na vida diária avaliada pelos pedômetros nessa população.

ABSTRACT Considering the wide use of functional tests and that faster and simpler evaluations are preferable, this study aimed to verify the association between five protocols of simple functional tests (timed up and go [TUG], four-meter gait speed [4MGS] and sit-to-stand [STS] in five-repetitions [STS5rep], 30-seconds [STS30sec] and one-minute [STS1min] protocols) and the six-minute walk test (6MWT), as well as physical activity in daily life (PADL) in healthy young subjects. In this cross-sectional study, PADL was quantified by a pedometer validated for step counting and we considered the mean of seven consecutive days during the time awake. We assessed functional capacity by the TUG, 4MGS, STS5rep, STS30sec, and STS1min tests and the 6MWT. A total of 79 subjects without lung functional impairments were included (49% male, aged 28 [23-36] years). Performance of simple functional tests correlated with the 6MWT (0.23<r <0.56; P<0.05 for all) and the TUG test showed the best association (R2= 0.34). However, simple functional tests did not correlate with PADL (0.03< r <0.13; P>0.05 for all). The less time-consuming functional tests were weakly-moderately related to the 6MWT in healthy young subjects. The TUG showed the best association and explained up to 34% of the 6MWT. However, the 6MWT cannot be replaced by none of these simple functional tests. Finally, functional capacity showed no association with physical activity in daily life assessed by the pedometers in this population.

RESUMEN Teniendo en cuenta el amplio uso de los tests funcionales y que son preferibles evaluaciones más rápidas y sencillas, el objetivo de este estudio fue verificar la asociación entre cinco protocolos de tests funcionales, a saber, timed up and go [TUG], 4-meter gait speed [4MGS] and sit to stand [STS] in 5-repetitions [STS5rep], 30-seconds [STS30sec] and 1-minute [STS1min] protocols y la prueba de caminata de 6 minutos (6MWT), con la actividad física de la vida diaria (AFVD) en jóvenes sanos. En este estudio transversal, la AFVD se cuantificó mediante un podómetro validado para el conteo de pasos, y se consideró el promedio de siete días consecutivos durante el tiempo acordado. La capacidad funcional se evaluó mediante TUG, 4MGS, STS5rep, STS30sec, STS1min y 6MWT. Se incluyeron a 79 personas sin afectación pulmonar (49% hombres, edad media 28 años). El desempeño en los tests funcionales se correlacionó con la 6MWT (0,23< r <0,56; p<0,05 para todos), y el TUG tuvo la mejor asociación (R²=0,34). Sin embargo, los tests funcionales simples no se correlacionaron con la AFVD (0,03<r<0,13; p>0,05 para todos). Los tests funcionales a corto plazo fueron insuficientes, moderadamente relacionados con la 6MWT en jóvenes sanos. El TUG mostró la mejor asociación y explicó hasta el 34% de la 6MWT, pero este no puede reemplazarse por ninguno de los tests funcionales simples. Por último, la capacidad funcional no se relacionó con la actividad física en la vida diaria evaluada por podómetros en esta población.

https://doi.org/10.1590/1809-2950/20016529022022en

15.

Association between obesity and hospitalization in mild COVID-19 adult outpatients in Brazil: a prospective cohort study
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Sartor, Ivaine Tais Sauthier

; David, Caroline Nespolo de

; Telo, Gabriela Heiden

; Zavaglia, Gabriela Oliveira

; Fernandes, Ingrid Rodrigues

; Kern, Luciane Beatriz

; Polese-Bonatto, Márcia

; Azevedo, Thaís Raupp

; Santos, Amanda Paz

; Almeida, Walquiria Aparecida Ferreira de

; Porto, Victor Bertollo Gomes

; Varela, Fernanda Hammes

; Scotta, Marcelo Comerlato

; Rosa, Regis Goulart

; Stein, Renato T.

Archives of Endocrinology and Metabolism

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aug 2022, Volume 66 N. 4 Pages 512 - 521

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: To evaluate the association between obesity and hospitalization in mild COVID-19 adult outpatients in Brazil. Subjects and methods: Adults with signs and symptoms suggestive of acute SARS-CoV-2 infection who sought treatment in two hospital (public and private) emergency departments were prospectively enrolled. Patients with confirmed COVID-19 at inclusion were followed by phone calls at days D7, D14 and D28. Multivariable logistic regression models were employed to explore the association between obesity and other potential predictors for hospitalization. Results: A total of 1,050 participants were screened, and 297 completed the 28-day follow-up and were diagnosed with COVID-19 by RT-PCR. The median age was 37.2 (IQR 29.7-44.6) years, and 179 (60.0%) were female. The duration of symptoms was 3.0 (IQR 2.0-5.0) days, and 10.0 (IQR 8.0-12.0) was the median number of symptoms at inclusion. Ninety-five (32.0%) individuals had obesity, and 233 (78.5%) had no previous medical conditions. Twenty-three participants (7.7%) required hospitalization during the follow-up period. After adjusting, obesity (BMI ≥ 30.0 kg/m2) (OR = 2.69, 95% CI 1.63-4.83, P < 0.001) and older age (OR = 1.05, 95% CI 1.01-1.09, P < 0.001) were significantly associated with higher risks of hospitalization. Conclusion: Obesity, followed by aging, was the main factor associated with hospital admission for COVID-19 in a young population in a low-middle income country. Our findings highlighted the need to promote additional protection for individuals with obesity, such as vaccination, and to encourage lifestyle changes.

https://doi.org/10.20945/2359-3997000000486

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