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Anatomic and refractional correlations in earliest glaucomatous visual field defects
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Matos, Alexis Galeno

; Bisneto, João Augusto Lima

; Lopes, Felipe Moraes

; Gurgel, Hermano Queiroz

; Faria, Magno Martins Pinto de

Arquivos Brasileiros de Oftalmologia

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2024, Volume 87 N. 1 elocation 2021-0042

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Purpose: In glaucoma, initial visual field scotomas can be peripheral or central, whereas central scotomas are more severe and can disrupt daily activities. Individual anatomical features may influence the distribution of retinal nerve fibers and the starting site of visual field defects in glaucoma. In this study, we aimed to correlate myopia and hyperopia or anatomical variation of the disk-fovea angle with initial central or peripheral lesions in the visual field. Methods: This cross-sectional study included patients with primary open-angle glaucoma divided into a group of isolated central or peripheral scotomas in the visual field with MD > or equal to -6 dB, correlating with the degree of ametropia and anatomical variations, such as the disk-fovea angle. Results: We included 52 patients with glaucoma. Of 20 myopic patients, 6 (30%) had central scotomas, and 14 (70%) had peripheral scotomas. Of 32 hyperopic patients, 12 (37.5%) had central scotomas, and 20 (63.5%) had peripheral scotomas. Regarding the disk-fovea angle, 25 eyes had the disk-fovea angle of < -7°, with 9 (36%) eyes presenting with central scotoma, and 27 eyes presented with the disk-fovea angle of > -7°, with 9 (33.3%) eyes presenting with a central scotoma. Conclusion: This study showed an association between ametropia and scotomas on the perimetry in patients with glaucoma. Patients had a higher incidence of peripheral scotomas, but hyperopic patients had a greater number of central scotomas than myopic patients, and myopic patients had more peripheral scotomas than hyperopic patients. The disk-fovea angle was not correlated with scotomas in initial glaucoma.

RESUMO Objetivos: No glaucoma, os escotomas iniciais no campo visual podem ser periféricos ou centrais. Os escotomas centrais são mais graves e podem atrapalhar as atividades diárias. As características anatômicas individuais podem influenciar a distribuição das fibras nervosas da retina e o local inicial dos defeitos do campo visual no glaucoma. Nesse estudo buscamos correlacionar a miopia e a hipermetropia ou a variação anatômica do ângulo disco-fóvea com lesões iniciais centrais ou periféricos no campo visual. Métodos: Este foi um estudo transversal incluindo pacientes com glaucoma primário de ângulo aberto divididos em grupo de escotomas isolados central ou periférico no campo visual com MD > ou igual a -6 dB, correlacionando com o grau de ametropia e variações anatômicas como o ângulo disco fóvea. Resultados: Incluímos 52 pacientes com glaucoma. Dos 20 míopes, 6 (30%) apresentaram escotoma central e 14 (70%) escotoma periférico) e 32 olhos hipermetrópicos com 12 (37,5%) escotomas centrais e 20 (63,5%) escotomas periféricos. Sobre o ângulo disco fóvea, 25 olhos tiveram ângulo disco fóvea menor que -7º com 9 (36%) olhos apresentando escotoma central e 27 olhos com ângulo disco fóvea maior que -7º com 9 (33,3%) olhos apresentando escotoma central. Conclusão: Este estudo mostrou associação da ametropia e os escotomas na perimetria em pacientes com glaucoma. Pacientes apresentaram maior incidência de escotomas periféricos, porém hipermétropes apresentaram maior quantidade de escotoma central que os míopes e os míopes mais escotomas periféricos que os hipermetropes. O ângulo disco fóvea não foi correlacionado com escotomas na perimetria no glaucoma inicial.

https://doi.org/10.5935/0004-2749.2021-0042

[SciELO Preprints] - IDENTITIES AND SCHOOL CULTURES OF INTEGRATED SECONDARY EDUCATION GRADUATES AT IFTM CAMPUS PATROCÍNIO
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Oliveira, Vinícius Felipe Silva, Thiago de Faria e

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Publication date: 2023-11-16

Abstract: En Es Pt

The route of professional education in Brazil is characterized by educational duality, which relegates workers to precarious work-oriented training, while ensuring elites a complete education. In a context where there are attacks on the project of a democratic, inclusive and universal school, it is necessary to understand the identities and the role of institutions and people in strengthening education. The objective of this article is to analyze the school cultures of integrated secondary education graduates, based on their narratives and memories, and their contribution to the construction of identities at the IFTM Campus Patrocínio. This is a qualitative approach. Data has been obtained through a questionnaire applied to graduates of technical courses integrated secondary education, entering between 2014 and 2021, were submitted to content analysis methodology. The perceptions captured in the narratives of subjects were articulated to the concepts of school culture, memory and identity, considering the principles and concepts of integrated secondary education. In the conjuncture of educational policies that serve the market, to the detriment of the concretization of the universal school and omnilateral training project, it can be deduces that consolidating the teaching of an integrated method of professional education also depends on the valorization of life trajectories, incentive to participate and understanding the identities of all the actors and actresses of the academic community, especially students and graduates.

La trayectoria de la educación profesional en Brasil está marcada por la dualidad educativa, que relega a los trabajadores a una formación precaria, ligera y enfocada al mercado de trabajo, al tiempo que garantiza a las elites una formación más integral. En un contexto en el que se observan ataques al proyecto de escuela democrática, inclusiva y universal, es necesario comprender las identidades y el papel de las instituciones y las personas para fortalecer la educación. El objetivo de este artículo es analizar las culturas escolares de bachilleres integrados, a partir de sus narrativas y memorias, y su contribución a la construcción de identidades en el IFTM Campus Patrocínio. Se trata de una investigación cualitativa: los datos, obtenidos a través de un cuestionario aplicado a egresados y egresadas de cursos técnicos integrados a la enseñanza media, que ingresaron entre 2014 y 2021, fueron sometidos a análisis de contenido. Las percepciones captadas en las narrativas de los sujetos participantes se vincularon a los conceptos de cultura, memoria e identidad escolar, considerando los principios y conceptos de la educación secundaria integrada. Se infiere que, en un escenario de políticas educativas al servicio del mercado, en detrimento de la implementación del proyecto de escuela universal y de la formación omnilateral, la consolidación de la educación secundaria integrada con la formación profesional depende también de la valorización de las trayectorias de vida, la participación incentivadora y reconocimiento de las identidades de todos los actores y actrices de la comunidad académica, en particular estudiantes y egresados.

A trajetória da educação profissional no Brasil é marcada pela dualidade educacional, que relega aos trabalhadores uma formação precária, aligeirada, voltada ao mercado de trabalho, enquanto garante às elites uma formação mais abrangente. Em um contexto em que se observa ataques ao projeto da escola democrática, inclusiva e universal, é necessário compreender as identidades e o papel de instituições e pessoas para o fortalecimento da educação. O objetivo deste artigo é analisar as culturas escolares dos egressos do ensino médio integrado, a partir de suas narrativas e memórias, e sua contribuição para a construção de identidades no IFTM Campus Patrocínio. Trata-se de uma pesquisa qualitativa: os dados, obtidos por meio de questionário aplicado a egressos e egressas dos cursos técnicos integrados ao ensino médio, ingressantes entre 2014 e 2021, foram submetidos à análise de conteúdo. As percepções captadas nas narrativas dos sujeitos participantes foram articuladas aos conceitos de cultura escolar, memória e identidade, considerando os princípios e concepções do ensino médio integrado. Infere-se que, em um cenário de políticas educacionais que servem ao mercado, em detrimento da concretização do projeto da escola universal e da formação omnilateral, consolidar o ensino médio integrado à educação profissional depende, também, da valorização das trajetórias de vida, do incentivo à participação e do reconhecimento das identidades de todos os atores e atrizes da comunidade acadêmica, notadamente de estudantes e ex-estudantes.

https://doi.org/10.1590/SciELOPreprints.7362

Trayectorias del dolor en sujetos con afección post-covid-19: estudio prospectivo y transversal con evaluación presencial
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Kubota, Gabriel T

; Soares, Felipe HC

; da Fonseca, Alessandra S

; dos Santos-Rosa, Talita

; da Silva, Valquiria A

; Gouveia, Gisele R

; Faria, Viviane G

; da Cunha, Pedro HM

; Brunoni, André R

; Teixeira, Manoel J

; de Andrade, Daniel C

Revista de la Sociedad Española del Dolor

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apr 2023, Volume 30 N. 2 Pages 131 - 145

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Background: New-onset chronic pain has been acknowledged as part of the post-COVID-19 condition. However, available fine-grained data about its clinical phenotype, trajectories and main associated characteristics remain scarce. We described the distinct temporal evolutions of post-COVID-19 pain and their epidemiological and phenotypical features. Methods: A prospective cross-sectional study enrolled post-COVID-19 condition patients (i.e. who had persisting COVID-19-related symptoms over 30 days since their first positive laboratory test), whose COVID-19 diagnosis had been supported by RT-PCR of oral/nasopharyngeal swab or serology. They underwent in-person evaluations with a structured interview, pain and quality-of-life-related questionnaires and thorough physical examination. Chronic pain (CP) and probable neuropathic pain (NP) were defined according to IASP criteria. Results: The present study included 226 individuals, 177 (78.3 %) of whom presented over 3 months since their first COVID-19 symptom. New-onset pain occurred in 170 (75.2 %) participants and was chronic in 116 (68.2 %). A chronic course was associated with COVID-19-related hospitalization, new-onset fatigue, lower cognitive performance, motor and thermal sensory deficits, mood and sleep impairments and overall lower quality-of-life levels. Probable NP occurred in only 7.6 % new-onset pain patients, and was associated with pain chronification, new-onset fatigue, motor and thermal sensory deficits, mechanical allodynia and lower rates of SARS-CoV-2 vaccination. Previous CP was reported by 86 (38.1 %) individuals and had aggravated after the infection in 66 (76.7 %) of them, which was associated with orthostatic hypotension. Conclusions: Post-COVID pain phenomena follow different paths, which are associated with specific clinical and epidemiological features, and possibly distinct underlying mechanisms, prognostic and therapeutic implications. Significance: COVID-19-related pain usually follows a chronic course and is non-neuropathic. Its possible courses and phenotypes are associated with distinct clinical and epidemiological features. This suggests differing underlying mechnisms, which may have significant prognostic and therapeutic implications.

RESUMEN Antecedentes: El dolor crónico de nueva aparición se considera que forma parte de la condición o afección post-COVID-19. Sin embargo, los datos detallados existentes sobre el fenotipo clínico, las trayectorias y las principales características asociadas siguen siendo escasos. Describimos las distintas evoluciones temporales del dolor post-COVID-19 y sus rasgos epidemiológicos y fenotípicos. Métodos: Estudio prospectivo y transversal de pacientes con afección post-COVID-19 (es decir, con síntomas persistentes relacionados con la COVID-19 durante 30 días desde la primera prueba positiva de laboratorio) cuyo diagnóstico de COVID-19 estuviera basado en la RT-PCR de un frotis oral/nasofaríngeo o una serología. Se sometieron a evaluaciones presenciales mediante una entrevista estructurada, cuestionarios de dolor y calidad de vida y una exploración física exhaustiva. El dolor crónico (DC) y el dolor neuropático (DN) probablemente se definieron conforme a los criterios IASP. Resultados: El presente estudio incluyó 226 individuos, 177 (78,3 %) de los cuales se presentaron pasados más de 3 meses desde el primer síntoma de COVID-19. Tenían dolor de nueva aparición 170 (75,2 %) de los participantes y dolor crónico 116 (68,2 %). El curso crónico se asociaba a hospitalización por COVID-19, fatiga de nueva aparición, menor rendimiento cognitivo, déficits motores y sensitivos térmicos, alteraciones del ánimo y el sueño, y niveles generalmente inferiores de calidad de vida. El DN probable afectaba a solo el 7,6 % de los pacientes con dolor de nueva aparición y se asociaba a cronificación del dolor, fatiga de nueva aparición, déficits motores y de sensación térmica, alodinia mecánica y tasas menores de vacunación frente al SARS-CoV-2. Referían DC previo 86 (38,1 %) individuos, y este había empeorado tras la infección en 66 (76,7 %) de ellos, lo que se asociaba a hipotensión ortostática. Conclusiones: Los fenómenos dolorosos post-COVID siguen diferentes trayectorias que se asocian a rasgos clínicos y epidemiológicos específicos, y posiblemente a distintos mecanismos de base y diferentes implicaciones pronósticas y terapéuticas. Significado: El dolor relacionado con la COVID-19 sigue normalmente un curso crónico y no es neuropático. Los posibles cursos y fenotipos se asocian a rasgos clínicos y epidemiológicos distintos. Esto sugiere que los mecanismos de base difieren, lo que podría tener implicaciones pronósticas y terapéuticas importantes.

https://doi.org/10.1002/ejp.2094

Impact of objective knowledge and self-assessed knowledge on the population's attitudes towards the Brazilian agribusiness
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Borges, João Augusto Rossi

; Souza, Kauê Felipe Ramos de

; Domingues, Carla Heloisa de Faria

; Talamini, Edson

Revista de Economia e Sociologia Rural

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mar 2023, Volume 61 N. 3 elocation e258427

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo No Brasil, circulam informações positivas e negativas sobre o agronegócio. É nesse contexto que a população forma suas atitudes frente ao agronegócio brasileiro. As atitudes estão relacionadas ao conhecimento objetivo, ou seja, as informações científicas acuradas ou dados consolidados que o indivíduo tem em sua memória; e ao conhecimento autoavaliado, ou seja, aquilo que o indivíduo julga saber. O objetivo foi identificar o impacto do conhecimento objetivo e do conhecimento autoavaliado sobre o agronegócio brasileiro nas atitudes da população. Os dados foram coletados por meio da aplicação de questionário com uma amostra de 468 participantes e analisados utilizando estatística descritiva e um modelo de regressão ordinal. Os resultados demonstraram que quanto maior o conhecimento objetivo e quanto maior o conhecimento autoavaliado maior é a probabilidade de um indivíduo ter atitudes positivas frente ao agronegócio. Os resultados também demonstraram que indivíduos com posicionamento político mais a direita tem maior probabilidade de ter atitudes positivas frente ao agronegócio brasileiro.

Abstract In Brazil, positive and negative information is spread about agribusiness. In this context of positive and negative information, the population forms its attitudes towards Brazilian agribusiness. Attitudes are related to objective knowledge, that is, accurate scientific information or consolidated data the individual has in his/her memory, and self-assessed knowledge, that is, what the individual thinks she or he knows. The objective was to identify the impacts of objective knowledge and self-assessed knowledge about Brazilian agribusiness on the population's attitudes. Data were collected through the application of questionnaire to a sample of 468 participants. Data were analyzed using descriptive statistics, and an ordinal logistic regression model. The results show that the greater the objective knowledge and the greater the self-assessed knowledge, the greater the probability of an individual having a more positive attitudes towards Brazilian agribusiness. The results also show that the further to the right on the political spectrum the individual declared himself/herself, the greater the probability of showing more positive attitudes towards the Brazilian agribusiness.

https://doi.org/10.1590/1806-9479.2022.258427

Amorphous breast calcifications: is BI-RADS 4a appropriate?
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Oliveira, Tatiane Mendes Gonçalves de

; Seksenian, Rafael Melo

; Santana, José Galdino Souza

; Souza, Bárbara Nogueira Caracas de

; Jesus, Felipe Alves de

; Faria, Francesca Maia

; Mandarano, Larissa Raquel Mouro

Radiologia Brasileira

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mar 2023, Volume 56 N. 2 Pages 75 - 80

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Objective: To evaluate the positive predictive value (PPV) of amorphous calcifications and to analyze the imaging variables that could alter the risk of malignancy associated with this finding. Materials and Methods: This was a retrospective study of 138 stereotactically guided percutaneous vacuum-assisted biopsies of amorphous calcifications, performed between January 2012 and December 2017. All of the patients included were referred for radiological follow-up for a minimum of one year (if the histopathology showed a benign lesion) or for surgical treatment (if the histopathology showed malignancy or a lesion of uncertain malignant potential). Results: We found that the PPV of amorphous calcifications was 9.42%. However, most of the malignant amorphous calcifications were in cases of invasive carcinoma or high-grade ductal carcinoma in situ, indicating clinically relevant disease. The relative risk of malignancy associated with amorphous calcifications was 6.15 times higher in patients with a family or personal history of breast or ovarian cancer. Neither being postmenopausal nor having dense breasts was found to be predictive of malignancy in patients with amorphous calcifications. Conclusion: Amorphous calcifications in the breast had a PPV for malignancy of 9.42%, indicating the possibility of placing the finding in subcategory 4a, which requires histopathological analysis. Our finding that the risk of malignancy associated with this subtype of calcifications is up to 6.15 times higher in patients with a family or personal history of breast cancer warrants greater concern regarding the clinical, radiologic, and histopathologic correlations after biopsy.

Resumo Objetivo: Avaliar o valor preditivo positivo (VPP) das calcificações amorfas e possíveis variáveis clínicas e de imagem que possam influenciar no risco de malignidade deste achado de imagem. Materiais e Métodos: Foram revisados, retrospectivamente, 138 resultados de biópsias percutâneas estereotáxicas a vácuo de calcificações amorfas, entre janeiro de 2012 e dezembro de 2017. Todas as pacientes incluídas apresentavam seguimento radiológico mínimo de um ano (histopatológico benigno) ou tratamento cirúrgico (histopatológico maligno). Resultados: O VPP das calcificações amorfas foi de 9,42%. As lesões malignas corresponderam predominantemente a carcinomas invasivos, indicando doença clinicamente relevante. O risco relativo de malignidade das calcificações amorfas foi 6,15 vezes maior em pacientes com história familiar ou pessoal de neoplasia de mama ou ovário. Status pós-menopausa e mamas densas não foram preditores de malignidade nessas pacientes. Conclusão: As calcificações amorfas na mama apresentaram VPP de malignidade de 9,42%, sugerindo possibilidade de classificação do achado na subcategoria 4a, com necessidade de investigação histopatológica. Em pacientes com história familiar ou pessoal de câncer de mama, o risco de malignidade deste subtipo de calcificações pode ser até 6,15 vezes maior, justificando maior preocupação na correlação clínica, radiológica e histopatológica após biópsia.

https://doi.org/10.1590/0100-3984.2022.0085-en

Dysgenesis of the posterior segment of the corpus callosum: don’t miss SPG45! callosum dont don t SPG45 SPG SPG4
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Guimarães, Daniel de Faria

; Almeida, Ana Luiza Viegas de

; Scortegagna, Felipe Alba

; Nunes, Renato Hoffmann

; Amorim, Simone Consuelo

; Pacheco, Felipe Torres

; Kok, Fernando

; Rocha, Antonio José da

Arquivos de Neuro-Psiquiatria

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mar 2023, Volume 81 N. 3 Pages 322 - 323

Abstract: En | Text: En | PDF: En

https://doi.org/10.1055/s-0043-1763299

Laboratory Evaluation of Tundish Covering Powders and Rice Hull Ash on Cleanliness for a SAE 1055 Modified Steel
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Ferreira, Felipe Buboltz

; Klug, Jeferson Leandro

; Pereira, Julio Anibal Morales

; Bielefeldt, Wagner Viana

; Vilela, Antônio Cezar Faria

Materials Research

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2023, Volume 26 elocation e20220216

Abstract: En | Text: En | PDF: En

Abstract The continuous casting tundish is the last metallurgical reactor where molten metal flows before solidifying in the continuous casting mold. A tundish covering powder can be used for improving steel cleanliness; in this case it is named ‘active tundish slag’. The objective of this work is to evaluate, in laboratory, the effect of three kinds of tundish covering powders on cleanliness for a SAE 1055 modified steel - a Ca-aluminate, a Ca-Mg-aluminate, and an Al-silicate powder, analysing their interaction with rice hull ash. The forementioned materials were molten on liquid steel, representing different kinds of tundish covering powders which are used in the steel industry: a Ca-Mg-aluminate, an Al-silicate, and a Ca-aluminate. Experiments were performed with and without a top layer of rice hull ash, simulating industrial conditions. Distribution, density, and mean diameter of inclusions were measured through automated inclusion analyses. Through computational thermodynamics it was possible to evaluate deviation from saturation (considering Al2O3 and MgO from refractory) and slag viscosity. It can be stated that the Ca-aluminate tundish covering powder gives better results regarding cleanliness for the SAE 1055 modified steel under laboratory conditions.

https://doi.org/10.1590/1980-5373-mr-2022-0216

Molecular profile of patients with myelofibrosis: a 10-year experience
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Dias, Lara Faria Souza

; Pereira, Carolina Leme de Moura

; Centurião, Newton de Freitas

; Nascimento, Jade Zezzi Martins do

; Ribeiro, Andreza Alice Feitosa

; Hamerschlak, Nelson

; Marques, Carolina Perrone

; Lima, Ana Carolina Vieira de

; Costa, Luana Nóbrega da

; Silva, Anderson Felipe da

; Lima, Viviane de Jesus Torres

; Kerbauy, Mariana Nassif

; Kerbauy, Lucila Nassif

; Arcuri, Leonardo Javier

; Campregher, Paulo Vidal

; Rocha, Juliana Dall´Agnol da

; Datoguia, Tarcila Santos

; Santos, Fabio Pires de Souza

einstein (São Paulo)

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2023, Volume 21 elocation eAO0100

Abstract: En | Text: En | PDF: En

ABSTRACT Objective To analyze the karyotype test and myeloid panel with next-generation sequencing findings in patients with myelofibrosis, and to compare transplant characteristics in patients referred for bone marrow transplantation. Methods Retrospective, single-center study with patients diagnosed with myelofibrosis treated at Hospital Israelita Albert Einstein between 2010 and 2020. Results A total of 104 patients with myelofibrosis were examined. Patients who had not been submitted to tests in our service were excluded. The final sample comprised 69 patients. Of these 69, 56 were submitted to karyotyping and 22 to myeloid panel with next-generation sequencing. Karyotype was normal in 60% of the patients and altered in 40%. The prevalence of high-risk molecular mutations was higher in patients referred for bone marrow transplantation (100% versus 50%). The median follow-up of transplant patients was 2.4 years and the overall survival at 2 years was 80% (95%CI: 62-100%). Conclusion The molecular analysis enables estimating the patient’s risk and thus instituting more aggressive treatment such as bone marrow transplant for patients at higher risk, being a relevant tool to guide therapy. Given the significance of molecular analysis for therapeutic decision-making in myelofibrosis, collection and disclosure of data on the prevalence of cytogenetic changes and findings of next-generation sequencing in affected patients is important.

https://doi.org/10.31744/einstein_journal/2023ao0100

Avaliação do comportamento das fibras colágenas periodontais durante a progressão da periodontite experimental em ratos
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GARCIA, Matheus Esnel

; FARIA, Felipe de Lima

; DAL OCA COSTA SILVA, Bianca

; ERVOLINO, Edilson

; NOVAES, Vivian Cristina Noronha

; TORO, Luan Felipe

Revista de Odontologia da UNESP

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2023, Volume 52 elocation e20230011

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Introduction Periodontitis is an infectious-inflammatory disease resulting from microbial dysbiosis and host response that leads to the destruction of tooth support tissues, including periodontal collagen fibers, which may culminate in tooth loss. Objective To evaluate the behavior of periodontal collagen fibers during the progression of induced experimental periodontitis in rats. Material and method Twelve Wistar rats were distributed into groups: Control (C), 14-days Experimental Periodontitis (PE-14d), 21-days Experimental Periodontitis (PE-21d) and 42-days Experimental Periodontitis (PE-42d). At day 0, the animals of group C were euthanized. At the same day, the remaining animals were submitted to the installation of a cotton ligature around the lower left first molar for the induction of experimental periodontitis. The animals were euthanized at 14 (PE-14d), 21 (PE-21d) and 42 (PE-42d) days after the installation of ligature. Histological processing of the hemi-mandibles was performed and the sections underwent histochemical reaction using picro-sirius red. The descriptive qualitative analysis was performed under polarized light microscopy, in the dental furcation region, evidencing the fibers of the periodontal ligament. Result Group C exhibited thick and oriented bundles of mature collagen fibers, consistent with a normal appearance. The groups with experimental periodontitis exhibited severe tissue disruption, with immature and thinner collagen fibers, with such conditions being more exacerbated in the PE-14d and PE-21d groups. Conclusion The early stages of periodontitis present acute response, and therefore result in rapid destruction of periodontal support tissues and potentially impair fibrillogenesis and collagen restructuring in the periodontal ligament.

Resumo Introdução A periodontite é uma doença infecto-inflamatória, resultante da disbiose microbiana e da resposta do hospedeiro, que leva à destruição dos tecidos de suporte dentário, inclusive das fibras colágenas periodontais, podendo culminar na perda do elemento dental. Objetivo Avaliar o comportamento das fibras colágenas periodontais durante a progressão da periodontite experimental induzida em ratos. Material e método Doze ratos Wistar foram distribuídos nos grupos: Controle (C), Periodontite Experimental 14-dias (PE-14d), Periodontite Experimental 21-dias (PE-21d) e Periodontite Experimental 42-dias (PE-42d). No dia 0, os animais do grupo C foram eutanasiados. Neste mesmo dia, os animais remanescentes foram submetidos à instalação de uma ligadura de algodão ao redor do primeiro molar inferior esquerdo para indução da periodontite experimental. Tais animais foram eutanasiados aos 14 (PE-14d), 21 (PE-21d) e 42 (PE-42d) dias após a instalação da ligadura. Executou-se o processamento histológico das hemimandíbulas e as secções foram submetidas à reação histoquímica pelo vermelho picro-sirius. A análise qualitativa descritiva foi realizada sob microscopia de luz polarizada, na região de furca dental, evidenciando as fibras do ligamento periodontal. Resultado O grupo C exibiu feixes espessos e orientados de fibras colágenas maduras, condizentes com aspecto de normalidade. Os grupos com periodontite experimental exibiram desestruturação tecidual severa, com fibras colágenas imaturas e de menor espessura, sendo tais condições mais exacerbadas nos grupos PE-14d e PE-21d. Conclusão As fases iniciais da periodontite apresentam caráter agudo e, portanto, resultam na rápida destruição dos tecidos periodontais de suporte, prejudicando potencialmente a fibrilogênese e a reestruturação do colágeno no ligamento periodontal.

https://doi.org/10.1590/1807-2577.01123

10.

Polymorphisms in TIE2 and ANGPT-1 genes are associated with protection against diabetic retinopathy in a Brazilian population
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Dieter, Cristine

; Lemos, Natália Emerim

; de Faria Corrêa, Nathalia Rodrigues

; Assmann, Taís Silveira

; Pellenz, Felipe Mateus

; Canani, Luís Henrique

; Brondani, Letícia de Almeida

; Bauer, Andrea Carla

; Crispim, Daisy

Archives of Endocrinology and Metabolism

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2023, Volume 67 N. 5 elocation e000624

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: The objective of this study was to investigate the association between SNPs in the TIE2 and ANGPT-1 genes and diabetic retinopathy (DR). Subjects and methods: This study comprised 603 patients with type 2 diabetes mellitus (T2DM) and DR (cases) and 388 patients with T2DM for more than 10 years and without DR (controls). The TIE2 rs639225 (A/G) and rs638203 (A/G) SNPs and the ANGPT-1 rs4324901 (G/T) and rs2507800 (T/A) SNPs were genotyped by real-time PCR using TaqMan MGB probes. Results: The G/G genotype of the rs639225/TIE2, the G/G genotype of the rs638203/TIE2 and the T allele of the rs4324901/ANGPT-1 SNPs were associated with protection against DR after adjustment for age, glycated hemoglobin, gender, and presence of hypertension (P = 0.042, P = 0.003, and P = 0.028, respectively). No association was found between the rs2507800/ANGPT-1 SNP and DR. Conclusion: We demonstrated, for the first time, the association of TIE2 rs638203 and rsrs939225 SNPs and ANGPT-1 rs4324901 SNP with protection against DR in a Brazilian population.

https://doi.org/10.20945/2359-3997000000624

11.

Epoxy/Graphite Composite Electrode Modified with Recycled Silver Nanoparticles: An Eco-Friendly Strategy to Improve Lead Detection
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Cabral, Taíssa S.

; Nascimento, Suéllen F. L. do

; Faria, Lucas V. de

; Lisboa, Thalles P.

; Borges, Pedro H. S.

; Nossol, Edson

; Semaan, Felipe S.

; Dornellas, Rafael M.

; Pacheco, Wagner F.

Journal of the Brazilian Chemical Society

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2023, Volume 34 N. 12 Pages 1788 - 1795

Abstract: En | Text: En | PDF: En

In this work, silver nanoparticles (AgNPs) obtained from photographic waste were synthesized and electrodeposited via cyclic voltammetry using epoxy-graphite composite as an electrochemical substrate. Both electrodes, unmodified (Epoxy/C) and modified (Epoxy/C/AgNPs), were characterized electrochemically by electrochemical impedance spectroscopy (EIS), charge transfer constant (K0), and electroactive area. The modified electrode provided lower charge transfer resistance (275 Ω), more kinetically favored electron transfer (K0 = 1.15 × 10-3 cm s-1), and a 1.7-fold increase in the active area compared to the unmodified electrode. Additional characterizations by scanning electron microscopy (SEM) and Raman spectroscopy confirmed the presence of AgNPs structures on the carbonaceous surface. As a proof of concept, Pb2+ was used as a model analyte, and a square wave anodic stripping voltammetry (SWASV) method was developed to evaluate the analytical performance of both electrodes. A wider linear range (4.0 to 40.0 µg L-1), the appropriate limit of detection (1.2 µg L-1), and a 6-fold increase in sensitivity were found using the modified electrode, suggesting that the AgNPs significantly contributed to the performance of the electrode. The proposed method was applied to three real water samples, where the Pb2+ levels varied from 11.3 to 19.5 µg L-1. The proposed protocol (reuse of silver waste) has proven to be a powerful tool for improving the detection of Pb2+, which can be helpful for other electrochemical sensing applications in locations with minimal infrastructure.

https://doi.org/10.21577/0103-5053.20230071

12.

Herpetofauna of protected areas in the Caatinga VIII: An updated checklist for the Serra das Confusões region with new data from Serra Vermelha, Piauí, Brazil
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Marques, Ricardo

; Garda, Adrian A.

; Furtado, Adriana P.

; Bruinjé, Andre C.

; Protázio, Arielson dos S.

; de Carvalho, Breno F.

; Vieira, Cecília R.

; Gomes, Dandara

; Pantoja, Davi L.

; Figueiredo, Diainara da S.

; Shepard, Donald B.

; Camurugi, Felipe

; Coelho, Felipe E. A.

; Magalhães, Felipe M.

; Caetano, Gabriel H. O.

; Colli, Guarino R.

; Paulino, Henrique M.

; Carvalho, Izabelle T. S.

; Graciene, Joedma

; Alvarenga, Júlio M.

; Clay, Natalie A.

; Albuquerque, Ralph L.

; Bosque, Renan J.

; Faria, Renato

; da Silveira-Filho, Ricardo R.

; Mângia, Sarah

; Cavalcante, Vitor H. G. L.

; Vieira, Washington L. S.

; da Silva, Willianilson P.

; Soares, Yan F. F.

; Mesquita, Daniel O.

Biota Neotropica

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2023, Volume 23 N. 4 elocation e20231520

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract It is repeatedly stressed the need to characterize the extant biodiversity in tropical ecosystems. However, inventory studies are still progressing slowly in dry ecosystems, leading to the underestimation of their true biodiversity and hindering conservation efforts. In this study, we present primary and secondary data, along with an updated list of amphibians and reptiles from two localities in the São Francisco-Gurguéia region in Piauí. Additionally, we compare the species composition between nine areas within the Caatinga, which were sampled using standardized methods over the past ten years, to examine broader spatial patterns of community composition. To survey reptiles and amphibians, we employed similar methods and sampling efforts in two areas within the Serra das Confusões National Park (SCNP) region. Our surveys recorded a total of 73 species of amphibians and reptiles, of which 24 are new distribution records for the SCNP region. Consequently, our findings increase the known herpetofauna in the region to 94 species. Despite their proximity, the two sites in the SCNP region exhibited only 42% similarity in species composition, and they differed significantly from other areas within the Caatinga. Furthermore, even the closer Caatinga areas presented differences in species composition, highlighting the necessity to evaluate biodiversity across the landscape and contribute to understanding biogeographic patterns.

Resumo É repetidamente enfatizada a necessidade de caracterizar a biodiversidade vivente em ecossistemas tropicais. No entanto, os estudos de inventário ainda estão progredindo lentamente em ecossistemas secos, levando à subestimação de sua verdadeira biodiversidade e dificultando os esforços de conservação. Neste estudo, apresentamos dados primários e secundários, juntamente com uma lista atualizada de anfíbios e répteis de duas localidades na região de São Francisco-Gurguéia, do Piauí. Além disso, comparamos a composição de espécies entre nove áreas dentro da Caatinga, que foram amostradas usando métodos padronizados nos últimos dez anos, para examinar padrões espaciais mais amplos de composição da comunidade. Para estudar répteis e anfíbios, utilizamos métodos e esforços de amostragem semelhantes em duas áreas na região do Parque Nacional da Serra das Confusões (PNSC). Nossos levantamentos registraram um total de 73 espécies de anfíbios e répteis, das quais 24 são novos registros de distribuição para a região do PNSC. Consequentemente, nossos resultados aumentam a herpetofauna conhecida na região para 94 espécies. Apesar da proximidade, os dois locais na região do PNSC exibiram apenas 42% de similaridade na composição de espécies e diferiram significativamente de outras áreas dentro da Caatinga. Mesmo áreas mais próximas da Caatinga apresentaram diferenças na composição de espécies, destacando a necessidade de avaliar a biodiversidade em toda a paisagem e contribuir para a compreensão de padrões biogeográficos.

https://doi.org/10.1590/1676-0611-bn-2023-1520

13.

Biological performance of Leptoglossus zonatus (Dallas) (Hemiptera: Coreidae) on corn genotypes
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Canassa, Vinícius Fernandes

; Medeiros, Fabiana Campos

; Bastos, Luiz Felipe Souza

; Faria, Rodrigo Donizeti

; Santos, Thais Lohaine Braga dos

; Cabral, Isabella Rubio

; Lourenção, André Luiz

; Baldin, Edson Luiz Lopes

Bragantia

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2023, Volume 82 elocation e20230049

Abstract: En | Text: En | PDF: En

ABSTRACT Corn, Zea mays (L.), is one of the most expressive crops in Brazil, due to its wide-ranging uses as animal feeding, biofuel production or used for human consumption. However, there is a huge gap between the actual yield and the natural yield potential of the crop, due to insects’ attack. Leptoglossus zonatus (Dallas) (Hemiptera: Coreidae) is a key corn pest in seed producing regions, due to its attack on corn ears. Plant resistance is a valuable tool for Integrated Pest Management systems and may maintain insect populations at a level that is below an economic or damage threshold. This study aimed to evaluate the biological performance of L. zonatus in different corn genotypes, under laboratory conditions, searching for possible characterization of antibiosis/antixenosis. To achieve this goal, ten nymphs (1st instar) were transferred to polyvinylchloride (PVC) ring containing a corn ear (R6) of each genotype. Each ring corresponded to one replicate, for a total of five replicates per genotype in a completely randomized design. The parameters assessed included the duration of each instar, nymphal period, nymphal survival (%), percentage of mortality of each nymphal stage, adult longevity, and adult weight. The results demonstrate that XB 8018 Bt, 30F53, IAC Airan, XB 8030 and 30F53 YHR genotypes reduced the mean survival and caused high mortality of L. zonatus nymphs at the second instar (above 75.00%) indicating the occurrence of antibiosis/antixenosis. The higher mortality rates were observed at the second nymphal instar.

https://doi.org/10.1590/1678-4499.20230049

14.

Tradução e adaptação transcultural do Questionário de Escolhas Alimentares para Adolescentes Brasileiros (FCQ-A-BR)
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Fontes, Vanessa Sequeira

; Neves, Felipe Silva

; Binoti, Mirella Lima

; Carrasco Asín, Paola Isabel

; Oliveira, Renata Maria Souza

; Faria, Eliane Rodrigues de

; Pereira Netto, Michele

; Cândido, Ana Paula Carlos

Cadernos Saúde Coletiva

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dec 2022, Volume 30 N. 4 Pages 538 - 547

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução Instrumentos que busquem conhecer os motivos que propiciam as escolhas alimentares em adolescentes são inexistentes no Brasil até o momento. O Food Choice Questionnaire (FCQ) para adolescentes é um questionário de fácil aplicação e que pode ser utilizado não somente em pesquisas, mas também nos serviços de atenção à saúde. Objetivo Descrever as etapas iniciais - validade de face e de conteúdo - do processo de tradução e adaptação transcultural do FCQ para adolescentes da versão em espanhol para o português do Brasil. Método Trata-se de um estudo metodológico de tradução e adaptação transcultural, em conformidade com as normas internacionais para tradução de instrumentos para validação. Foram seguidas quatro etapas: tradução, retradução, avaliação por comitê de especialistas e dois pré-testes, que foram realizados com adolescentes com idades entre 14 e 19 anos. Resultados Os itens e o título do instrumento foram traduzidos para o português. Alguns itens necessitaram de ajustes para melhor compreensão do público-alvo. O tempo médio de aplicação foi de sete minutos. Um item foi eliminado do questionário e modificou-se a escala de resposta para melhor adequação do instrumento. Conclusão O processo inicial de tradução e adaptação transcultural do Questionário de Escolhas Alimentares para Adolescentes Brasileiros (FCQ-A-BR) atestou as validades de face e conteúdo. No entanto, faz-se necessária a complementação das análises psicométricas, para utilização do instrumento, caso elas se mostrem satisfatórias.

Abstract Background Instruments that seek to find out the reasons that lead to food choices among adolescents are not yet available in Brazil so far. The Food Choice Questionnaire (FCQ) for adolescents is a simple questionnaire that can be used not only in research, but also in healthcare. Objective To describe the initial steps - face and content validity - of the process of translation and cross-cultural adaptation of the FCQ for adolescents from the Spanish version into Brazilian Portuguese. Method This is a methodological study of translation and cross-cultural adaptation, in accordance with international standards for translation of instruments for validation. Four steps were followed: translation, back-translation, evaluation by an expert committee and two pre-tests, which were carried out with adolescents aged between 14 and 19 years. Results The items and the instrument title were translated to Portuguese. Some items needed adjustments to better understand the target audience. The average application time was seven minutes. One item was eliminated from the questionnaire and the response scale was modified to better suit the instrument. Conclusion The initial process of translation and cross-cultural adaptation of the Food Choice Questionnaire for Brazilian Adolescents (FCQ-A-BR) attested to the face and content validity. However, it is necessary to complement the psychometric analyses, to use the instrument, if they are satisfactory.

https://doi.org/10.1590/1414-462x202230040107

15.

Midterm Radiographic Results and Reoperations of Tantalum Trabecular Metal Cones in Knee Arthroplasties
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Minamoto, Sandra Tie Nishibe

; Silva, Luís Felipe Tupinambá da

; Faria, José Leonardo Rocha de

; Cobra, Hugo Alexandre de Araujo Barros

; Palma, Idemar Monteiro da

; Mozella, Alan de Paula

Revista Brasileira de Ortopedia

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oct 2022, Volume 57 N. 5 Pages 734 - 740

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo O manejo da perda óssea representa um grande desafio em cirurgias de revisão de artroplastia do joelho (rATJ) e em artroplastias totais do joelho (ATJ) primárias complexas. O objetivo do presente estudo foi avaliar os resultados em médio prazo (seguimento mínimo de 5 anos) das reconstruções de joelho nas quais cones de metal trabecular (MT) de tântalo foram utilizados para tratamento de defeitos ósseos tipos 2 e 3, de acordo com a classificação proposta pela Anderson Orthopaedic Research Institute (AORI). Métodos Feita análise retrospectiva dos prontuários dos pacientes operados entre julho de 2008 e novembro de 2014, coletando-se os seguintes dados: idade, gênero, lateralidade, índice de massa corporal, etiologia da artrose, comorbidade, classificação AORI da falha óssea, causa da revisão da artroplastia total do joelho, reinternações, reoperações, complicações peri- e pós-operatórias, ocorrência de osteointegração radiográfica e manutenção da função de suporte do MT. Resultados Foram avaliados 11 pacientes com tempo médio de seguimento de 7,28 anos (desvio padrão [DP] = 1,88; variação = 5,12–10 anos), sendo que 1 paciente foi submetido a artroplastia primária, 6 a artroplastia de revisão e 4 a segunda revisão de artroplastia (re-revisão). Três pacientes necessitaram de quatro reoperações devido a complicações com a ferida operatória, a lesão do mecanismo extensor e a soltura do componente femoral. Sinais de osteointegração dos cones trabeculados foram observados em todos os pacientes. Não observamos migração do cone de MT ou dos componentes protéticos. Conclusão Os cones metafisários de tântalo foram capazes de prover suporte estrutural eficiente aos implantes protéticos com sinais radiográficos de osteointegração em médio prazo.

Abstract Objective The management of bone loss represents a challenge in revisions of total knee arthroplasty (rTKA) and in complex primary total knee arthroplasties (TKAs). The purpose of the present study was to evaluate the midterm outcomes (5-year minimum follow-up) of knee reconstructions with tantalum trabecular metal (TM) cones on bone defects Anderson Orthopaedics Research Institute (AORI) 2 and 3. Materials and MethodsA retrospective analysis of the medical records of patients operated on between July 2008 and November 2014 was performed, collecting the following data: age, gender, laterality, body mass index, etiology of arthrosis, comorbidities, AORI classification of bone defects, causes for revision, readmissions, reoperations, perioperative and postoperative complications, radiographic signs of osteointegration, and maintenance of the TM support. Results A total of 11 patients with a mean follow-up of 7.28 years (standard deviation [SD] = 1.88; range = 5.12–10 years) was evaluated, with 1 patient operated upon for a primary arthroplasty, 6 for revision arthroplasties, and 4 for a second revision arthroplasty (re-revision). There were complications with the surgical wound, injury to the extensor mechanism and loosening of the femoral component in three of the patients that led to the necessity of four procedures due to complications with the surgical wound, injury to the extensor mechanism and loosening of the femoral component. Radiological signs of osteointegration of the trabecular cones were observed in all patients. We did not observe migration of the TM cones or the prosthetic components in the sample. Conclusion The tantalum metaphyseal cones were able to provide efficient structural support to prosthetic implants with radiographic signs of osteointegration in the medium term.

https://doi.org/10.1055/s-0041-1739465

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