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Abstract The Santos Basin (SB) is the main petroliferous basin in the Brazilian continental margin and one of the most studied marine areas in Brazil. However, historical data suggest that new efforts should be carried out to acquire quantitative biological data, especially in the deep sea, to establish the baseline of essential ocean variables in different ecosystems for future monitoring programs. The Brazilian energy company Petrobras planned and executed 24 oceanographic cruises over a period of 2 years to assess the benthic (SANSED cruise) and pelagic (SANAGU cruise) systems of the SB (356 days at sea in 2019 and 2021/2022). These efforts were part of the Santos Project, which comprised a comprehensive environmental study aimed at investigating benthic and pelagic variables to characterize ecology, biogeochemistry, thermohaline properties of water masses, and ocean circulation patterns, geomorphology, and sedimentology, as well as organic and inorganic chemistry. Here we present the detailed sampling designs and the field methods employed on board, during the SB scientific cruises. All sampling protocols were based on standardized approaches. For the benthos analyses, triplicate sediment samples were performed using a GOMEX-type box corer (0.25 m²) or a large modified Van Veen grab (0.75 m²) at 100 stations ranging from 25 to 2400 m depth. At each station, 25 geochemical and physico-chemical parameters were analyzed in addition to micro-, meio-, and macrofauna and living foraminifera samples. For the pelagic system, 60 stations were selected to investigate the plankton community, ranging in size from pico- to macroplankton, through vertical, horizontal, and oblique net hauls (20, 200, and 500 μm mesh size), as well as 25 biogeochemical parameters collected with an aid of a CTD-rosette sampler. Part of this scientific information also serves the Regional Environmental Characterization Project (PCR-BS) in support of Petrobras’ Santos Basin drilling licensing process led by the Brazilian Environmental Agency – IBAMA. This project contributes to the sustainable development of the SB, in line with the guidelines of the United Nations Decade of Ocean Science for Sustainable Development.

https://doi.org/10.1590/2675-2824071.22072dlm

Geotecnologías aplicadas al análisis de la fragilidad ambiental a los procesos erosivos
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dos Santos da Silva, Edson Rodrigo

; Fernandes Ribeiro de Oliveira, Vincler

; da Rocha Lima, César Gustavo

; Salinas Chávez, Eduardo

; Bacani, Vitor Matheus

; Vick, Erivelton Pereira

Cuadernos de Geografía: Revista Colombiana de Geografía

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jun 2022, Volume 31 N. 1 Pages 222 - 240

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

Resumen Los procesos erosivos tienen graves impactos sobre el ambiente, generando importantes pérdidas económicas, sociales y de biodiversidad. Este trabajo tiene como objetivo analizar la fragilidad ambiental asociada a los procesos erosivos en la cuenca del arroyo La Onça, en Coxim, Mato Grosso do Sul-Brasil. La metodologia se sustenta en la cartografia de los suelos, la inclinación de las pendientes, las áreas prioritarias para la conservación de la biodiversidad y la intensidad de la lluvia, con vistas a evaluar la fragilidad potencial que, unida al mapa del uso y cobertura de la tierra por la superposición booleana ponderada, permite obtener la fragilidad ambiental. Para validar este modelo se realizó la identificación de los sitios con erosión, a partir de una imagen de alta resolución y el levantamiento de las áreas llamadas "suelos con exposición extrema" mediante la identificación de áreas que presentan el menor grado de protección del suelo. Los resultados muestran el predominio en la cuenca de las zonas con fragilidad ambiental media (59,61 %) y alta (23,66 %), asociada a una gran concentración de los procesos erosivos en áreas de baja cobertura vegetal, identificadas en el mapa de uso y cobertura de la tierra como áreas de pastos. Ideas destacadas: Articulo de investigación que tiene como premisa el análisis de la fragilidad ambiental asociada a los procesos erosivos dentro de la cuenca del arroyo La Onça (Coxim-Ms). Se utilizaron geotecnologias para el análisis sistémico, estableciendo medidas dirigidas a ayudar en la toma de decisiones para el manejo y conservación del área.

Resumo Os processos erosivos ocasionam severos impactos ao ambiente, gerando perdas económicas, sociais e de biodiversidade. Este trabalho analisa a fragilidade do ambiente a processos erosivos na bacia hidrográfica do córrego da Onça, em Coxim-MS. A metodologia se fundamentou em mapeamentos de solos, declividade, áreas prioritárias à conservação da biodiversidade e na intensidade pluviomètrica para avaliar a fragilidade potencial e no mapeamento de uso e cobertura da terra que, por meio de sobreposição booleana ponderada resultou um mapeamento da fragilidade ambiental. Para validar esse modelo, foram identificados, pontualmente, as feições erosivas a partir de uma imagem de alta resolução e também um levantamento, com enfoque nas áreas nominadas de "solos com exposição extrema", que teve como objetivo a identificação de áreas que apresentam o menor grau de proteção/cobertura do solo. Os resultados apontaram o predominio de média (59,61 %) e alta (23,66 %), associadas a grandes concentrações de processos erosivos em área de "solo com exposição extrema", áreas de baixa cobertura vegetal, classificadas no uso e cobertura da terra com as classes de pastagem. Ideias destacadas: Artigo de investigação que tem como premissa a análise da fragilidade ambiental associada aos processos erosivos na bacia do córrego da Onça (Coxim-MS), empregando-se as geotecnologias para a análise sistêmica do ambiente, estabelecendo medidas propositivas, que auxiliem na tomada de decisões para o manejo e conservação da área.

Abstract Erosive processes cause severe impacts on the environment, causing economic, social, and biodiversity losses. This paper aims to analyze the fragility of the environment to erosive processes in the Onça river basin, in Coxim-MS. The methodology was based on soil mapping, slope, priority areas for biodiversity conservation, and rainfall intensity to evaluate the potential fragility and land use and land cover, that by means of a boolean weighted overlap with the potential fragility resulted in the mapping of the environmental fragility. To validate the environmental fragility model, the erosive features were identified from a high-resolution image and a making, focusing on the areas named "soils with extreme exposure" from a classification, which had as its only aim to identify areas with the lowest degree of protection/ground cover. The results pointed to the predominance of medium (59.61 %) and high (23.66 %) environmental fragility, associated with high concentrations of erosive processes in "soil with extreme exposure" area, which are areas of low vegetation cover, classified by use. and land cover with the pasture classes. Main ideas: Research article that has as premise the analysis of environmental fragility to erosive processes within the watershed of the Onça stream (Coxim-MS), using geotechnologies for the systemic analysis of the environment, establishing propositional measures that assist in taking decisions for the management and conservation of the area.

https://doi.org/10.15446/rcdg.v31n1.85654 29 downloads

Donor-derived TB after kidney transplantation: a case report
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Ulisses, Luiz Roberto de Sousa

; Cardoso, Helen Souto Siqueira

; Alves, Inara Creão Costa

; Medeiros, Isabela Novais

; Oliveira, Camilla Garcia de

; Almeida, Tiago Martins de

; Castro, Fabíola Fernandes dos Santos

; Silva, Claudia Neto Gonçalves Neves da

; Lima, Laura Viana de

; Fontoura, Renata Pereira

; Silva, Eduardo Resende Sousa e

; Araújo, Pollyana Lopes de

; Ferreira, Gustavo de Sousa Arantes

Brazilian Journal of Nephrology

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mar 2022, Volume 44 N. 1 Pages 126 - 129

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução: A tuberculose (TB) é uma possível complicação grave do transplante de órgãos sólidos, associada à alta mortalidade e morbidade. A TB pós-transplante tem patogênese variada com muitas abordagens para sua prevenção, que é a forma mais importante de reduzir sua incidência. O tratamento da TB em receptores de órgãos é um desafio devido à toxicidade dos medicamentos e à interação com imunossupressores. Relato de caso: uma mulher de 18 anos que foi submetida a transplante renal de um doador falecido e recebeu alta com função renal adequada foi readmitida no 37º dia de pós-operatório com febre. A TC mostrou sinais de TB miliar e coleção de fluidos além de fistulização do enxerto através da pele. A paciente apresentou BAAR positivo no fluido drenado e bacilo de Koch na urina. Ela foi tratada com um esquema de quatro medicamentos (rifampicina, isoniazida, pirazinamida e etambutol), com ótima resposta e função de enxerto preservada. Fomos informados de que o receptor do rim contralateral também apresentou TB pós-transplante, implicando em uma origem derivada do doador. Conclusão: A TB é um importante diagnóstico diferencial para complicações infecciosas em pacientes após transplante de órgãos sólidos, especialmente em regiões endêmicas. Sua apresentação clínica inicial pode não ser específica e deve ser suspeitada na presença de febre ou formação de coleções de fluidos. A suspeita de TB é a chave para o diagnóstico precoce e desfechos satisfatórios na TB pós-transplante.

Abstract Introduction: Tuberculosis (TB) is a possible serious complication of solid organ transplantation, associated with high mortality and morbidity. Post-transplant TB has varied pathogenesis with many approaches to its prevention, which is the most important way to reduce its incidence. Treatment of TB in organ recipients is challenging because of drug toxicity and interaction with immunosuppressants. Case report: an 18-year-old woman that underwent kidney transplantation from a deceased donor and was discharged with fair renal function was readmitted at 37th postoperative day with fever. CT showed signs of miliary TB and fluid collection besides graft fistulization through the skin. The patient presented positive BAAR in the drained fluid and Koch's bacillus in the urine. She was treated with a four-drug regimen (rifampicin, isoniazid, pyrazinamide, and etambutol), with great response and preserved graft function. We were informed that the recipient of the contralateral kidney also presented post-transplant TB, implying in a donor-derived origin. Conclusion: TB is an important differential diagnosis for infectious complications in patients after solid-organ transplantation, especially in endemic regions. Its initial clinical presentation can be unspecific and it should be suspected in the presence of fever or formation of fluid collections. The suspicion of TB is the key to early diagnosis and satisfactory outcomes in post-transplant TB.

https://doi.org/10.1590/2175-8239-jbn-2020-0117

National Brazilian survey on the outcomes of hepatitis c retreatment in patients non-responders to direct antiviral agents
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Ferraz, Maria Lúcia Gomes

; Piccoli, Leonora de Zorzi

; Rezende, Rosamar

; Borba, Luiz Augusto

; Pissaia Junior, Alcindo

; Cheinquer, Hugo

; Silva, Giovanni Faria

; Ferreira, Paulo Roberto Abrão

; Villela-Nogueira, Cristiane Alves

; Mazo, Daniel Ferraz

; Souza, Fernanda Fernandes

; Codes, Liana

; Ivantes, Claudia Alexandra Pontes

; Gomide, Geisa Perez Medina

; Pereira, Gustavo Henrique Santos

; Pessôa, Mário Guimarães

; França, Alex Vianey Callado

; Pinto, Arlene dos Santos

; Teixeira, Rosângela

; Bittencourt, Paulo Lisboa

Brazilian Journal of Infectious Diseases

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2022, Volume 26 N. 4 elocation 102388

Abstract: En | Text: En | PDF: En

ABSTRACT Background and aims: Treatment of hepatitis C with direct antiviral agents (DAA) is associated with almost 95% of sustained virological response. However, some patients need retreatment. In Brazil, it should be done according to the Ministry of Health guidelines, frequently updated to include newly available drugs. This study aimed to conduct a national survey about the characteristics and outcomes of retreatment of hepatitis C in previously non-responders to DAAs. Patients and methods: Institutions from all over the country were invited to participate in a national registry for retreatment, including information about clinical and epidemiological characteristics of the patients, type and outcomes of retreatment regimens. Only patients previously treated with interferon-free regimens were included. Results: As previous treatments the distribution was: SOF/DCV (56%), SOF/SIM (22%), 3D (11%), SOF/LED (6%) and SOF/RBV (5%). For retreatment the most frequently used drugs were SOF/GP (46%), SOF/DCV (23%) and SOF/VEL (11%). From 159 patients retreated, 132/159 (83%) had complete information in the registry and among them only seven patients were non-responders (SVR of 94.6%). All retreatments were well tolerated, without any serious adverse events or interruptions. Conclusion: The retreatment of patients previously non-responders to DAAs was associated with high rate of SVR in this sample of Brazilian patients. This finding allows us to conclude that the retreatment options available in the public health system in Brazil are effective and safe and are an important component of the strategy of elimination of hepatitis C in our country.

https://doi.org/10.1016/j.bjid.2022.102388

A Produção da Identidade Política de Mulheres em uma Comunidade Quilombola do Sertão Alagoano
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Silva, Liliane Santos Pereira

; Silva, Gustavo Barbosa

; Fernandes, Saulo Luders

; Galindo, Dolores Cristina Gomes

; Cazeiro, Felipe

Psicologia: Ciência e Profissão

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2022, Volume 42 elocation e240443

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract This study is part of a qualitative research aiming to analyze the political identity formation along three generations of women from the Cajá dos Negros quilombola community, located in the rural area of the municipality of Batalha, state of Alagoas. The research participants were three residents of the community (18-year-old, 26-year-old adult, and 60-year-old woman), who experienced struggles and confrontations with the system of domination and the search for the rupture of racist and sexist social structures in their trajectories. To produce information, we used participant observation, field diaries, and semi-structured interviews as instruments. The analysis of the registered narratives and observations were based on the content analysis method, by deepening the pre-analysis, exploring the material, in which two thematic categories were constructed: the quilombola political identity in the subjective formation of black women and the expression of political identity in different generations. As a strengthened community space, the women focused on in the study are neighbors, lifelong friends, and companions in the struggle, features that enable the political unlocking in affirming a collective, black, and ancestral identity. The analyses point to the nuances of the elaborated identity productions, which are renewed by each generation, with unique characteristics to each one of them, but which still maintain elaborations of belonging, struggle, and transformation of their lives and of the community.

Resumen Este estudio es parte de una investigación cualitativa, cuyo objetivo es analizar la formación de identidad política en tres generaciones de mujeres de la comunidad quilombola Cajá dos Negros, ubicada en el área rural de la ciudad de Batalha - AL. Los participantes de la investigación fueron tres residentes de la comunidad (18 años, 26 años, mujer adulta y 60 años), que experimentaron luchas y confrontaciones con el sistema de dominación y la búsqueda de la ruptura de las estructuras sociales racistas y sexistas en sus trayectorias. Para la producción de información, utilizamos la observación participante, los diarios de campo y las entrevistas semiestructuradas como instrumentos. El análisis de las narrativas y observaciones registradas comenzó desde el método de análisis de contenido, a través de la profundización del preanálisis, la exploración del material, en el que se construyeron dos categorías temáticas: la identidad política de Quilombola en la formación subjetiva de las mujeres negras y la expresión de la identidad política en diferentes generaciones. Como un espacio comunitario fortalecido, las mujeres presentadas en el estudio son vecinas, amigas de la vida y compañeras en la lucha, características que permiten el desbloqueo político en la afirmación de una identidad colectiva, negra y ancestral. Los análisis apuntan a los matices de las elaboradas producciones de identidad, que son renovadas por cada generación, con características únicas para cada una de ellas, pero que aún mantienen elaboraciones de pertenencia, lucha y transformación de sus vidas y la comunidad.

Resumo Este estudo parte de uma pesquisa de cunho qualitativo, objetivando analisar a formação da identidade política ao longo de três gerações de mulheres da comunidade quilombola Cajá dos Negros, situada na zona rural da cidade de Batalha, Alagoas. As participantes da pesquisa foram três moradoras da comunidade (jovem de 18 anos, adulta de 26 anos e uma idosa de 60 anos), que apresentaram, em suas trajetórias, vivências de lutas e enfrentamentos ao sistema de dominação e de busca pelo rompimento de estruturas sociais racistas e sexistas. Para a produção das informações, foram utilizados, como instrumentos, a observação participante, os diários de campo e as entrevistas semiestruturadas. A análise das narrativas e observações registradas foram amparadas no método de análise de conteúdo, mediante o aprofundamento da pré-análise, exploração do material, quando foram construídas duas categorias temáticas: a identidade política quilombola na formação subjetiva de mulheres negras e a expressão da identidade política nas diferentes gerações. Como um espaço comunitário fortalecido, as mulheres focalizadas no estudo são vizinhas, amigas de vida e companheiras de luta, feições que possibilitam os destraves políticos na afirmação de uma identidade coletiva, negra e ancestral. As análises apontam as nuances das produções identitárias elaboradas, as quais se renovam a cada geração, com características singulares a cada uma delas, mas que mantêm em si elaborações de pertencimento, luta e transformação de suas vidas e da comunidade.

https://doi.org/10.1590/1982-3703003e240443

Atualização de Tópicos Emergentes da Diretriz Brasileira de Insuficiência Cardíaca – 2021
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Marcondes-Braga, Fabiana G.

; Moura, Lídia Ana Zytynski

; Issa, Victor Sarli

; Vieira, Jefferson Luis

; Rohde, Luis Eduardo

; Simões, Marcus Vinícius

; Fernandes-Silva, Miguel Morita

; Rassi, Salvador

; Alves, Silvia Marinho Martins

; Albuquerque, Denilson Campos de

; Almeida, Dirceu Rodrigues de

; Bocchi, Edimar Alcides

; Ramires, Felix José Alvarez

; Bacal, Fernando

; Rossi Neto, João Manoel

; Danzmann, Luiz Claudio

; Montera, Marcelo Westerlund

; Oliveira Junior, Mucio Tavares de

; Clausell, Nadine

; Silvestre, Odilson Marcos

; Bestetti, Reinaldo Bulgarelli

; Bernadez-Pereira, Sabrina

; Freitas Jr, Aguinaldo F.

; Biolo, Andréia

; Barretto, Antonio Carlos Pereira

; Jorge, Antônio José Lagoeiro

; Biselli, Bruno

; Montenegro, Carlos Eduardo Lucena

; Santos Júnior, Edval Gomes dos

; Figueiredo, Estêvão Lanna

; Fernandes, Fábio

; Silveira, Fabio Serra

; Atik, Fernando Antibas

; Brito, Flávio de Souza

; Souza, Germano Emílio Conceição

; Ribeiro, Gustavo Calado de Aguiar

; Villacorta, Humberto

; Souza Neto, João David de

; Goldraich, Livia Adams

; Beck-da-Silva, Luís

; Canesin, Manoel Fernandes

; Bittencourt, Marcelo Imbroinise

; Bonatto, Marcely Gimenes

; Moreira, Maria da Consolação Vieira

; Avila, Mônica Samuel

; Coelho Filho, Otavio Rizzi

; Schwartzmann, Pedro Vellosa

; Mourilhe-Rocha, Ricardo

; Mangini, Sandrigo

; Ferreira, Silvia Moreira Ayub

; Figueiredo Neto, José Albuquerque de

; Mesquita, Evandro Tinoco

Arquivos Brasileiros de Cardiologia

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jun 2021, Volume 116 N. 6 Pages 1174 - 1212

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210367 3168 downloads

Exome sequencing and targeted gene panels: a simulated comparison of diagnostic yield using data from 158 patients with rare diseases
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Quaio, Caio Robledo D’Angioli Costa

; Obando, María José Rivadeneira

; Perazzio, Sandro Felix

; Dutra, Aurelio Pimenta

; Chung, Christine Hsiaoyun

; Moreira, Caroline Monaco

; Novo Filho, Gil Monteiro

; Sacramento-Bobotis, Patricia Rossi

; Penna, Michele Groenner

; Souza, Rafaela Rogerio Floriano de

; Cintra, Vivian Pedigone

; Carnavalli, Juliana Emilia Prior

; Silva, Rafael Alves da

; Santos, Monize Nakamoto Provisor

; Paixão, Daniele

; Baratela, Wagner Antonio da Rosa

; Olivati, Caroline

; Spolador, Gustavo Marquezani

; Pintao, Maria Carolina

; Fornari, Alexandre Ricardo dos Santos

; Burger, Matheus

; Ramalho, Rodrigo Fernandes

; Pereira, Otavio Jose Eulalio

; Ferreira, Elisa Napolitano e

; Mitne-Neto, Miguel

; Kim, Chong Ae

Genetics and Molecular Biology

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2021, Volume 44 N. 4 elocation 20210061

Abstract: En | Text: En | PDF: En

Abstract Next-generation sequencing (NGS) has altered clinical genetic testing by widening the access to molecular diagnosis of genetically determined rare diseases. However, physicians may face difficulties selecting the best diagnostic approach. Our goal is to estimate the rate of possible molecular diagnoses missed by different targeted gene panels using data from a cohort of patients with rare genetic diseases diagnosed with exome sequencing (ES). For this purpose, we simulated a comparison between different targeted gene panels and ES: the list of genes harboring clinically relevant variants from 158 patients was used to estimate the theoretical rate of diagnoses missed by NGS panels from 53 different NGS panels from eight different laboratories. Panels presented a mean rate of missed diagnoses of 64% (range 14%-100%) compared to ES, representing an average predicted sensitivity of 36%. Metabolic abnormalities represented the group with highest mean of missed diagnoses (86%), while seizure represented the group with lowest mean (46%). Focused gene panels are restricted in covering select sets of genes implicated in specific diseases and they may miss molecular diagnoses of rare diseases compared to ES. However, their role in genetic diagnosis remains important especially for well-known genetic diseases with established genetic locus heterogeneity.

https://doi.org/10.1590/1678-4685-gmb-2021-0061 205 downloads

Diretriz Brasileira de Cardio-oncologia – 2020
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Hajjar, Ludhmila Abrahão

; Costa, Isabela Bispo Santos da Silva da

; Lopes, Marcelo Antônio Cartaxo Queiroga

; Hoff, Paulo Marcelo Gehm

; Diz, Maria Del Pilar Estevez

; Fonseca, Silvia Moulin Ribeiro

; Bittar, Cristina Salvadori

; Rehder, Marília Harumi Higuchi dos Santos

; Rizk, Stephanie Itala

; Almeida, Dirceu Rodrigues

; Fernandes, Gustavo dos Santos

; Beck-da-Silva, Luís

; Campos, Carlos Augusto Homem de Magalhães

; Montera, Marcelo Westerlund

; Alves, Sílvia Marinho Martins

; Fukushima, Júlia Tizue

; Santos, Maria Verônica Câmara dos

; Negrão, Carlos Eduardo

; Silva, Thiago Liguori Feliciano da

; Ferreira, Silvia Moreira Ayub

; Malachias, Marcus Vinicius Bolivar

; Moreira, Maria da Consolação Vieira

; Valente Neto, Manuel Maria Ramos

; Fonseca, Veronica Cristina Quiroga

; Soeiro, Maria Carolina Feres de Almeida

; Alves, Juliana Barbosa Sobral

; Silva, Carolina Maria Pinto Domingues Carvalho

; Sbano, João

; Pavanello, Ricardo

; Pinto, Ibraim Masciarelli F.

; Simão, Antônio Felipe

; Dracoulakis, Marianna Deway Andrade

; Hoff, Ana Oliveira

; Assunção, Bruna Morhy Borges Leal

; Novis, Yana

; Testa, Laura

; Alencar Filho, Aristóteles Comte de

; Cruz, Cecília Beatriz Bittencourt Viana

; Pereira, Juliana

; Garcia, Diego Ribeiro

; Nomura, Cesar Higa

; Rochitte, Carlos Eduardo

; Macedo, Ariane Vieira Scarlatelli

; Marcatti, Patricia Tavares Felipe

; Mathias Junior, Wilson

; Wiermann, Evanius Garcia

; Val, Renata do

; Freitas, Helano

; Coutinho, Anelisa

; Mathias, Clarissa Maria de Cerqueira

; Vieira, Fernando Meton de Alencar Camara

; Sasse, André Deeke

; Rocha, Vanderson

; Ramires, José Antônio Franchini

; Kalil Filho, Roberto

Arquivos Brasileiros de Cardiologia

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nov 2020, Volume 115 N. 5 Pages 1006 - 1043

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20201006 4180 downloads

10.

Registro Multicêntrico de Takotsubo (REMUTA) – Aspectos Clínicos, Desfechos Intra-Hospitalares e Mortalidade a Longo Prazo
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Almeida Junior, Gustavo Luiz Gouvêa de

; Mansur Filho, João

; Albuquerque, Denilson Campos de

; Xavier, Sergio Salles

; Pontes, Álvaro

; Gouvêa, Elias Pimentel

; Martins, Alexandre Bahia Barreiras

; Nunes, Nágela S. V.

; Carestiato, Lilian Vieira

; Petriz, João Luiz Fernandes

; Santos, Armando Márcio Gonçalves

; Bandeira, Bruno Santana

; Abufaiad, Bárbara Elaine de Jesus

; Pacheco, Luciana da Camara

; Oliveira, Maurício Sales de

; Ribeiro Filho, Paulo Eduardo Campana

; Sampaio, Pedro Paulo Nogueres

; Duque, Gustavo Salgado

; Camillis, Luiz Felipe

; Marques, André Casarsa

; Lourenço Jr, Francisco Carlos

; Palazzo, José Ricardo

; Costa, Cláudio Ramos da

; Silva, Bibiana Almeida da

; Zukowski, Cleverson Neves

; Garcia, Romulo Ribeiro

; Zonis, Fernanda de Carvalho

; Paula, Suzana Andressa Morais de

; Ferrari, Carolina Gravano Ferraz

; Rangel, Bruno Soares da Silva

; Ferreira, Roberto Muniz

; Mendes, Bárbara Ferreira da Silva

; Castro, Isabela Ribeiro Carvalho de

; Souza, Leonardo Giglio Gonçalves de

; Araújo, Luiz Henrique dos Santos

; Giani, Alexandre

Arquivos Brasileiros de Cardiologia

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aug 2020, Volume 115 N. 2 Pages 207 - 216

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento A síndrome de takotsubo (takotsubo) é uma forma de cardiomiopatia adquirida. Dados nacionais sobre essa condição são escassos. O Registro REMUTA é o primeiro a incluir dados multicêntricos dessa condição no nosso país. Objetivo Descrever as características clínicas, prognóstico, tratamento intra-hospitalar e mortalidade hospitalar e em 1 ano de seguimento. Métodos Estudo observacional, retrospectivo, tipo registro. Incluídos pacientes internados com diagnóstico de takotsubo ou que desenvolveram esta condição durante internação por outra causa. Os desfechos avaliados incluíram fator desencadeador, análise dos exames, uso de medicações, complicações e óbito intra-hospitalar e em 1 ano de seguimento. O nível de significância adotado foi de 5%. Resultados Foram incluídos 169 pacientes, em 12 centros no Estado do Rio de Janeiro. A idade média foi de 70,9 ± 14,1 anos e 90,5% eram do sexo feminino; 63% dos casos foram de takotsubo primário e 37% secundário. Troponina I foi positiva em 92,5% dos pacientes e a mediana de BNP foi de 395 (176,5; 1725). Supradesnivelamento do segmento ST esteve presente em 28% dos pacientes. A fração de ejeção do ventrículo esquerdo teve mediana de 40 (35; 48)%. Observamos taxa de 25,7% de ventilação mecânica invasiva e 17,4% de choque. Suporte circulatório mecânico foi utilizado em 7,7%. A mortalidade intra-hospitalar foi de 10,6% e a mortalidade ao final de 1 ano foi de 16,5%. Takotsubo secundário e choque cardiogênico foram preditores independentes de mortalidade. Conclusão Os resultados do REMUTA mostram que takotsubo não se trata de patologia benigna como se pensava, especialmente no grupo de takotsubo secundário que acarreta elevada taxa de complicações e de mortalidade. (Arq Bras Cardiol. 2020; 115(2):207-216)

Abstract Background Takotsubo syndrome (TTS) is an acquired form of cardiomyopathy. National Brazilian data on this condition are scarce. The Takotsubo Multicenter Registry (REMUTA) is the first to include multicenter data on this condition in Brazil. Objective To describe the clinical characteristics, prognosis, in-hospital treatment, in-hospital mortality, and mortality during 1 year of follow-up. Methods This is an observational, retrospective registry study including patients admitted to the hospital with diagnosis of TTS and patients admitted for other reasons who developed this condition. Evaluated outcomes included triggering factor, analysis of exams, use of medications, complications, in-hospital mortality, and mortality during 1 year of follow-up. A significance level of 5% was adopted. Results The registry included 169 patients from 12 centers in the state of Rio de Janeiro, Brazil. Mean age was 70.9 ± 14.1 years, and 90.5% of patients were female; 63% of cases were primary TTS, and 37% were secondary. Troponin I was positive in 92.5% of patients, and median BNP was 395 (176.5; 1725). ST-segment elevation was present in 28% of patients. Median left ventricular ejection fraction was 40 (35; 48)%. We observed invasive mechanical ventilation in 25.7% of cases and shock in 17.4%. Mechanical circulatory support was used in 7.7%. In-hospital mortality was 10.6%, and mortality at 1 year of follow-up was 16.5%. Secondary TTS and cardiogenic shock were independent predictors of mortality. Conclusion The results of the REMUTA show that TTS is not a benign pathology, as was once thought, especially regarding the secondary TTS group, which has a high rate of complications and mortality. (Arq Bras Cardiol. 2020; 115(2):207-216)

https://doi.org/10.36660/abc.20190166 1217 downloads

11.

Medical Residency in Gynecology and Obstetrics in Times of COVID-19: Recommendations of the National Specialized Commission on Medical Residency of FEBRASGO*
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Romão, Gustavo Salata

; Schreiner, Lucas

; Laranjeiras, Claudia Lourdes Soares

; Bella, Zsuzsanna Ilona Katalin de Jarmy Di

; Coelho, Raquel Autran

; Simões, Maria da Conceição Ribeiro

; Correa Júnior, Mario Dias

; Brito, Milena Bastos

; Steiner, Marcelo Luis

; Trapani Junior, Alberto

; Barcelos, Ionara Diniz Evangelista Santos

; Zaconeta, Alberto Carlos Moreno

; Reis, Francisco José Candido dos

; Abrão, Karen Cristina

; Botogoski, Sheldon Rodrigo

; Fortunato, Giovana da Gama

; Damasio, Lia Cruz Vaz da Costa

; Sá, Marcos Felipe Silva de

; Fernandes, César Eduardo

; Silva Filho, Agnaldo Lopes da

Revista Brasileira de Ginecologia e Obstetrícia

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jul 2020, Volume 42 N. 7 Pages 411 - 414

Abstract: En | Text: En | PDF: En

https://doi.org/10.1055/s-0040-1715147 451 downloads

12.

Two-dimensional beams in rectangular coordinates using the radial point interpolation method
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Fernandes, William Luiz

; Barbosa, Gustavo Botelho

; Rosa, Karine Dornela

; Silva, Emanuel

; Fernandes, Walliston dos Santos

REM - International Engineering Journal

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mar 2020, Volume 73 N. 1 Pages 9 - 16

Abstract: En | Text: En | PDF: En

Abstract The three-dimensional Theory of Elasticity equations lead to a complex solution for most problems in engineering. Therefore, the solutions are typically developed for reduced systems, usually symmetrical or two-dimensional. In this context, computational resources allow the reduction of these simplifications. The most recognized methods of algebraic approximation of the differential equations are the Finite Differences Method and the Finite Element Method (FEM). However, they have limitations in mesh generation and/or adaptation. As follows, Meshless Methods appear as an alternative to these options. The present work uses the Radial Point Interpolation Method (RPIM) to evaluate the stress in two-dimensional beams in regions close to loading (Saint Venant's Principle). Formulations based on the Fourier Series Theory and the RPIM are presented. Multiquadrics Radial Basis Functions were used to obtain the stiffness matrix. Two numerical examples demonstrate the validity of the RPIM for the proposed theme. The results were obtained from the formulations cited and the Finite Element Method for comparison.

https://doi.org/10.1590/0370-44672018730115 861 downloads

13.

DOF/DAF comparison for the treatment of milk industry wastewater
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Santos Pereira, Magno dos

; Borges, Alisson Carraro

; Muniz, Gustavo Lopes

; Heleno, Fernanda Fernandes

; Faroni, Lêda Rita D'Antonino

Revista Ambiente & Água

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2020, Volume 15 N. 5 elocation e2553

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste estudo foi avaliar a eficiência da flotação por ar e ozônio dissolvido (FAOD) em comparação à flotação por ar dissolvido (FAD) no tratamento da água residuária de laticínios (ARL). Na primeira fase do experimento foi utilizada água residuária de laticínios sintética (ARLS) para avaliar a FAD e a FAOD, com e sem a adição de peróxido de hidrogênio em dois valores de pH, 4,0 e 11,4. Nos testes de FAOD, a concentração de ozônio utilizada no ar foi igual a 19 (± 0,5) mg L-1 e nos testes com adição de peróxido de hidrogênio, as relações H2O2/O3 testadas foram de 0,5, 1,0 e 1,5. Na segunda parte do experimento, foram realizados testes com três ARL de três diferentes laticínios para validar os resultados obtidos e determinar a capacidade do sistema FAOD para tratar esse tipo de efluente. Os parâmetros testados durante a validação foram: turbidez, sólidos totais suspensos, óleos e graxas (O&G), demanda química de oxigênio (DQO), demanda bioquímica de oxigênio (DBO), nitrogênio total (NT) e fósforo total (PT). Ao final do experimento, observou-se que a eficiência dos tratamentos foi melhor em pH 4. Os resultados mostraram uma redução da eficiência com o uso da FAOD. A adição de H2O2 na FAD e FAOD também resultou em menor eficiência nos dois sistemas. Os resultados obtidos com ARLS aproximaram-se apenas dos obtidos com o ARL de uma das indústrias que continham os maiores traços de leite e queijo.

Abstract The objective of this study was to evaluate the efficiency of dissolved ozone flotation (DOF) in comparison to dissolved air flotation (DAF) for treatment of milk industry wastewater (MW). In the first phase of the experiment, a synthetic milk wastewater (SMW) was used to evaluate DOF and DAF, with and without addition of hydrogen peroxide, at pH 4.0 and pH 11.4. In the DOF tests, the concentration of ozone was equal to 19 (± 0.5) mg L-1 and in the tests with addition of hydrogen peroxide, the H2O2/O3 ratios tested were 0.5, 1.0 and 1.5. In the second phase, tests were performed using three MW from three different industries to validate the results obtained and to determine the DOF system's ability to treat this type of effluent. The parameters tested during validation were turbidity, total suspended solids, oils and greases (O&G), chemical oxygen demand (COD), biochemical oxygen demand (BOD), total nitrogen (TN) and total phosphorus (TP). It was observed that the efficiency of the treatments was better at pH 4.0. The results showed a reduction of the efficiency with the use of DOF. The addition of H2O2 in DAF and DOF also resulted in reduced system efficiency. The results obtained with SMW only approximated those obtained with the MW from one of the industries that contained the largest traces of milk and cheese.

https://doi.org/10.4136/ambi-agua.2553 919 downloads

14.

Characteristics and outcomes of patients with COVID-19 admitted to the ICU in a university hospital in São Paulo, Brazil - study protocol
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Ferreira, Juliana C.

; Ho, Yeh-Li

; Besen, Bruno A.M.P.

; Malbuisson, Luiz M.S.

; Taniguchi, Leandro U.

; Mendes, Pedro V.

; Costa, Eduardo L.V.

; Park, Marcelo

; Daltro-Oliveira, Renato

; Roepke, Roberta M.L.

; Silva Jr, João M.

; Carmona, Maria José C.

; Carvalho, Carlos Roberto Ribeiro

; Hirota, Adriana

; Kanasiro, Alberto Kendy

; Crescenzi, Alessandra

; Fernandes, Amanda Coelho

; Miethke-Morais, Anna

; Bellintani, Arthur Petrillo

; Canasiro, Artur Ribeiro

; Carneiro, Bárbara Vieira

; Zanbon, Beatriz Keiko

; Batista, Bernardo Pinheiro De Senna Nogueira

; Nicolao, Bianca Ruiz

; Besen, Bruno Adler Maccagnan Pinheiro

; Biselli, Bruno

; Macedo, Bruno Rocha De

; Toledo, Caio Machado Gomes De

; Pompilio, Carlos Eduardo

; Carvalho, Carlos Roberto Ribeiro De

; Mol, Caroline Gomes

; Stipanich, Cassio

; Bueno, Caue Gasparotto

; Garzillo, Cibele

; Tanaka, Clarice

; Forte, Daniel Neves

; Joelsons, Daniel

; Robira, Daniele

; Costa, Eduardo Leite Vieira

; Silva Júnior, Elson Mendes Da

; Regalio, Fabiane Aliotti

; Segura, Gabriela Cardoso

; Marcelino, Gustavo Brasil

; Louro, Giulia Sefrin

; Ho, Yeh-Li

; Ferreira, Isabela Argollo

; Gois, Jeison de Oliveira

; Silva Junior, Joao Manoel Da

; Reusing Junior, Jose Otto

; Ribeiro, Julia Fray

; Ferreira, Juliana Carvalho

; Galleti, Karine Vusberg

; Silva, Katia Regina

; Isensee, Larissa Padrao

; Oliveira, Larissa dos Santos

; Taniguchi, Leandro Utino

; Letaif, Leila Suemi

; Lima, Lígia Trombetta

; Park, Lucas Yongsoo

; Chaves Netto, Lucas

; Nobrega, Luciana Cassimiro

; Haddad, Luciana

; Hajjar, Ludhmila

; Malbouisson, Luiz Marcelo

; Pandolfi, Manuela Cristina Adsuara

; Park, Marcelo

; Carmona, Maria José Carvalho

; Andrade, Maria Castilho Prandini H De

; Santos, Mariana Moreira

; Bateloche, Matheus Pereira

; Suiama, Mayra Akimi

; Oliveira, Mayron Faria de

; Sousa, Mayson Laercio

; Louvaes, Michelle

; Huemer, Natassja

; Mendes, Pedro

; Lins, Paulo Ricardo Gessolo

; Santos, Pedro Gaspar Dos

; Moreira, Pedro Ferreira Paiva

; Guazzelli, Renata Mello

; Reis, Renato Batista Dos

; Oliveira, Renato Daltro De

; Roepke, Roberta Muriel Longo

; Pedro, Rodolpho Augusto De Moura

; Kondo, Rodrigo

; Rached, Samia Zahi

; Fonseca, Sergio Roberto Silveira Da

; Borges, Thais Sousa

; Ferreira, Thalissa

; Cobello Junior, Vilson

; Sales, Vivian Vieira Tenório

; Ferreira, Willaby Serafim Cassa

Clinics

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2020, Volume 75 elocation e2294

Abstract: En | Text: En | PDF: En

OBJECTIVES: We designed a cohort study to describe characteristics and outcomes of patients with coronavirus disease (COVID-19) admitted to the intensive care unit (ICU) in the largest public hospital in Sao Paulo, Brazil, as Latin America becomes the epicenter of the pandemic. METHODS: This is the protocol for a study being conducted at an academic hospital in Brazil with 300 adult ICU beds dedicated to COVID-19 patients. We will include adult patients admitted to the ICU with suspected or confirmed COVID-19 during the study period. The main outcome is ICU survival at 28 days. Data will be collected prospectively and retrospectively by trained investigators from the hospital’s electronic medical records, using an electronic data capture tool. We will collect data on demographics, comorbidities, severity of disease, and laboratorial test results at admission. Information on the need for advanced life support and ventilator parameters will be collected during ICU stay. Patients will be followed up for 28 days in the ICU and 60 days in the hospital. We will plot Kaplan-Meier curves to estimate ICU and hospital survival and perform survival analysis using the Cox proportional hazards model to identify the main risk factors for mortality. ClinicalTrials.gov: NCT04378582. RESULTS: We expect to include a large sample of patients with COVID-19 admitted to the ICU and to be able to provide data on admission characteristics, use of advanced life support, ICU survival at 28 days, and hospital survival at 60 days. CONCLUSIONS: This study will provide epidemiological data about critically ill patients with COVID-19 in Brazil, which could inform health policy and resource allocation in low- and middle-income countries.

https://doi.org/10.6061/clinics/2020/e2294 1957 downloads

15.

Barreiras arquitetônicas e de comunicação no acesso à atenção básica em saúde no Brasil: uma análise a partir do primeiro Censo Nacional das Unidades Básicas de saúde, 2012
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Santos, Mara Lisiane de Moraes dos

; Fernandes, Janainny Magalhães

; Vicente, Daniela Pereira

; Simionatto, Jaqueline

; Sanches, Vinicius Santos

; Souza, Albert Schiaveto de

; Christofoletti, Gustavo

; Merey, Leila Foester

Epidemiologia e Serviços de Saúde

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2020, Volume 29 N. 2 elocation e2018258

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Objetivo: analisar os resultados do Censo Nacional das Unidades Básicas de Saúde no que se refere às barreiras arquitetônicas e de comunicação na Atenção Básica em Saúde em todo o território brasileiro. Métodos: estudo transversal com base nos dados do primeiro Censo Nacional das Unidades Básicas de Saúde, coletados de maio a outubro de 2012. Resultados: a região Norte apresentou menores índices de adequação, enquanto a Sudeste apresentou os melhores índices, comparados às demais regiões, porém insatisfatórios, pois muitos itens permaneceram abaixo de 50%; itens sobre acessibilidade por pessoas com deficiência (5,7 a 34,2%) e não alfabetizadas (0,1 a 27,4%) apresentaram pontuação muito baixa. Conclusão: a maioria das unidades avaliadas possuem barreiras arquitetônicas e de comunicação, prejudicando a acessibilidade aos serviços de saúde prestados às pessoas com deficiência, não alfabetizadas ou idosas; destaca-se a importância da alocação de recursos para redução de iniquidades e melhoria do acesso.

Abstract Objective: to analyze the results of the National Census of Primary Health Care Centers with regard to architectural and communication barriers in Primary Health Care throughout Brazil. Methods: this was a cross-sectional study based on data from the first National Census of Primary Health Care Centers conducted between May and October 2012. Results: the Northern region had the lowest rates of adequacy; although the Southeast region had the best rates when compared to the country’s other regions, they were nevertheless unsatisfactory, since for many items adequacy was still below 50%; the items relating to accessibility by people with disabilities (5.7 to 34.2%) and/or the illiterate (0.1 to 27.4%) had very low scores. Conclusion: the majority of services evaluated had architectural and communication barriers, hindering access to health services by disabled, illiterate or elderly people; the importance of allocating resources to reduce iniquities and improve access is stressed.

Resumen Objetivo: analizar la accesibilidad de los usuarios al Censo Nacional de las Unidades Básicas de Salud en lo referente a barreras arquitectónicas y de comunicaciones en todo Brasil. Métodos: estudio descriptivo analítico con base en los datos del primer Censo Nacional de las Unidades Básicas de Salud; la encuesta se realizó entre mayo y octubre de 2012. Resultados: la región Norte presentó menores índices de adecuación, mientras que el Sudeste presentó mejores índices comparados a las demás regiones, pero insatisfactorios, pues muchos ítems permanecieron por debajo del 50%; los ítems sobre accesibilidad por personas con discapacidad (5,7 a 34,2%) y no alfabetizadas (0,1 a 27,4%) presentaron una puntuación muy baja. Conclusión: los datos demuestran que la mayoría de los servicios evaluados poseen barreras arquitectónicas y de comunicación, perjudicando la accesibilidad a los servicios de salud prestados a las personas con discapacidad, no alfabetizadas o ancianas, y exalta la importancia de asignación de recursos para la reducción de iniquidades y mejoría del acceso.

https://doi.org/10.5123/s1679-49742020000200022

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