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1.
Joint statement on evidence-based practices in mechanical ventilation: suggestions from two Brazilian medical societies
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Ferreira, Juliana Carvalho
; Vianna, Arthur Oswaldo de Abreu
; Pinheiro, Bruno Valle
; Maia, Israel Silva
; Baldisserotto, Sérgio Vasconcellos
; Isola, Alexandre Marini
; Cavalcanti, Alexandre Biasi
Gama, Ana Maria Casati Nogueira da
Rocha, Angelo Roncalli Miranda
Oliveira, Antonio Gonçalves de
Serpa Neto, Ary
Farias, Augusto Manoel de Carvalho
Orlando, Bianca Rodrigues
Esteves, Bruno da Costa
Mazza, Bruno Franco
Silveira, Camila de Freitas Martins Soares
Carvalho, Carlos Roberto Ribeiro de
Toufen Junior, Carlos
Barbas, Carmen Silvia Valente
Teixeira, Cassiano
Silveira, Débora Dutra da
Medeiros, Denise Machado
Parolo, Edino
Costa, Eduardo Leite Vieira
Caser, Eliana Bernadete
Oliveira, Ellen Pierre de
Banholzer, Eric Grieger
Carvalho, Erich Vidal
Amorim, Fabio Ferreira
Saddy, Felipe
Gonçalves, Fernanda Alves Ferreira
Galas, Filomena Regina Barbosa Gomes
Zanatta, Giovanna Carolina Gardini
Silva, Gisele Sampaio
Westphal, Glauco Adrieno
Matos, Gustavo Faissol Janot de
Souza, João Claudio Emmerich de
Silva Junior, João Manoel
Valiatti, Jorge Luis dos Santos
Nascimento Junior, José Ribamar do
Rocco, Jose Rodolfo
Hajjar, Ludhmila Abrahão
Forgiarini Junior, Luiz Alberto
Malbuisson, Luiz Marcelo Sá
Holanda, Marcelo Alcantara
Amato, Marcelo Britto Passos
Park, Marcelo
Oliveira, Marco Antonio da Rosa e
Reis, Marco Antonio Soares
Tavares, Marcos Soares
Souza, Mario Henrique Dutra de
Damasceno, Marta Cristina Pauleti
Lira-Batista, Marta Maria da Silva
Pattacini, Max Morais
Assunção, Murillo Santucci Cesar de
Oliveira, Neymar Elias de
Franzosi, Oellen Stuani
Rocco, Patricia Rieken Macedo
Caruso, Pedro
Silva, Pedro Leme
Mendes, Pedro Vitale
Duarte, Pericles Almeida Delfino
Santa Neto, Renato Fabio Alberto Della
Rodrigues, Ricardo Goulart
Cordioli, Ricardo Luiz
Palazzo, Roberta Fittipaldi
Goldwasser, Rosane
Pinheiro, Sabrina dos Santos
Justino, Sandra Regina
Nemer, Sergio Nogueira
Oliveira, Vanessa Martins de
Silva, Vinicius Zacarias Maldaner da
Nedel, Wagner Luis
Bellissimo-Rodrigues, Wanessa Teixeira
Oliveira Filho, Wilson de






ABSTRACT Mechanical ventilation can be a life-saving intervention, but its implementation requires a multidisciplinary approach, with an understanding of its indications and contraindications due to the potential for complications. The management of mechanical ventilation should be part of the curricula during clinical training; however, trainees and practicing professionals frequently report low confidence in managing mechanical ventilation, often seeking additional sources of knowledge. Review articles, consensus statements and clinical practice guidelines have become important sources of guidance in mechanical ventilation, and although clinical practice guidelines offer rigorously developed recommendations, they take a long time to develop and can address only a limited number of clinical questions. The Associação de Medicina Intensiva Brasileira and the Sociedade Brasileira de Pneumologia e Tisiologia sponsored the development of a joint statement addressing all aspects of mechanical ventilation, which was divided into 38 topics. Seventy-five experts from all regions of Brazil worked in pairs to perform scoping reviews, searching for publications on their specific topic of mechanical ventilation in the last 20 years in the highest impact factor journals in the areas of intensive care, pulmonology, and anesthesiology. Each pair produced suggestions and considerations on their topics, which were presented to the entire group in a plenary session for modification when necessary and approval. The result was a comprehensive document encompassing all aspects of mechanical ventilation to provide guidance at the bedside. In this article, we report the methodology used to produce the document and highlight the most important suggestions and considerations of the document, which has been made available to the public in Portuguese.
2.
Relato de experiência: coprodução do programa Qualis-APS para melhoria da qualidade da Atenção Primária à Saúde em Brasília
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Santos, Leonor Maria Pacheco
; Scherer, Magda Duarte dos Anjos
; Furlanetto, Denise de Lima Costa
; Pedrosa, Claudia Mara
; Freitas, Maria Silvia Fruet de
; Leite, Thais Alessa
; Santos, Wallace Enrico Boaventura Gonçalves Dos
.







RESUMO Para incentivar melhorias na qualidade da Atenção Primária à Saúde em Brasília, a Secretaria de Estado de Saúde do Distrito Federal (SES-DF) instituiu o Programa Qualis-APS em 2019: uma coprodução entre profissionais da assistência, gestores, pesquisadores da Universidade de Brasília e Fundação Oswaldo Cruz. Ao envolver gestores e trabalhadores na concepção, coordenação, planejamento e execução, almejou-se promover engajamento e senso de pertencimento, pré-requisitos para tomar decisões baseadas em evidências. Objetivou-se descrever a concepção e implementação da sistemática de avaliação e etapas do primeiro ciclo avaliativo, concluído em 2022: I. Diagnóstico da estrutura das 165 Unidades Básicas de Saúde; II. Elaboração de padrões de qualidade para compor instrumentos de autoavaliação, com base em subsídios obtidos nas oficinas com 544 profissionais de saúde e usuários; III. Desenvolvimento da Plataforma Qualis-APS; IV. Autoavaliação das 603 Equipes de Saúde da Família/Saúde Bucal, 100 equipes das Gerências da Atenção Primária à Saúde e 59 Equipes dos Núcleos Ampliados de Saúde da Família e Atenção Básica na Plataforma; V. Planejamento e elaboração do Plano de Ação para Qualidade pelas equipes; VI. Avaliação in loco das unidades básicas, por pesquisadores externos; VII. Certificação das equipes pela SES-DF. A experiência do primeiro ciclo foi exitosa; o segundo está em andamento.
ABSTRACT To encourage improvements in the quality of Primary Health Care in Brasília, the Federal District Health Department established the Qualis-APS Program in 2019, a co-production between healthcare professionals, managers and researchers from the University of Brasília and the Fundação Oswaldo Cruz. By involving managers and workers in the design, coordination, planning and execution, the aim was to promote engagement and a sense of ownership, prerequisites for evidence-based decision-making. The aim is to describe the conception and implementation of the evaluative process and the stages of the first evaluation cycle, concluded in 2022. I. Diagnosis of the structure of all 165 Basic Health Units; II. Elaboration of quality standards to compose self-assessment instruments, based on subsidies obtained in workshops with 544 health professionals and users; III. Development of the Qualis-APS Platform; IV. Self-assessment of the 603 Family Health Teams/Oral Health Teams, 100 Primary Health Care Management Teams and 59 Teams from the Expanded Family Health and Primary Care Centers on the Platform; V. Planning and elaboration of the Action Plan for Quality, made by the teams; VI. On-site evaluation of the Basic Units, by external researchers; VII. Certification of teams by the Health Department. The experience of the first cycle was successful and the second cycle is ongoing now.
3.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
Slipinski, Adam
Linzmeier, Adelita M.
Calor, Adolfo R.
Garda, Adrian A.
Kury, Adriano B.
Fernandes, Agatha C.S.
Agudo-Padrón, Aisur I.
Akama, Alberto
Silva Neto, Alberto M. da
Burbano, Alejandro L.
Menezes, Aleksandra
Pereira-Colavite, Alessandre
Anichtchenko, Alexander
Lees, Alexander C.
Bezerra, Alexandra M.R.
Domahovski, Alexandre C.
Pimenta, Alexandre D.
Aleixo, Alexandre L.P.
Marceniuk, Alexandre P.
Paula, Alexandre S. de
Somavilla, Alexandre
Specht, Alexandre
Camargo, Alexssandro
Newton, Alfred F.
Silva, Aline A.S. da
Santos, Aline B. dos
Tassi, Aline D.
Aragão, Allan C.
Santos, Allan P.M.
Migotto, Alvaro E.
Mendes, Amanda C.
Cunha, Amanda
Chagas Júnior, Amazonas
Sousa, Ana A.T. de
Pavan, Ana C.
Almeida, Ana C.S.
Peronti, Ana L.B.G.
Henriques-Oliveira, Ana L.
Prudente, Ana L.
Tourinho, Ana L.
Pes, Ana M.O.
Carmignotto, Ana P.
Wengrat, Ana P.G. da Silva
Dornellas, Ana P.S.
Molin, Anamaria Dal
Puker, Anderson
Morandini, André C.
Ferreira, André da S.
Martins, André L.
Esteves, André M.
Fernandes, André S.
Roza, André S.
Köhler, Andreas
Paladini, Andressa
Andrade, Andrey J. de
Pinto, Ângelo P.
Salles, Anna C. de A.
Gondim, Anne I.
Amaral, Antonia C.Z.
Rondón, Antonio A.A.
Brescovit, Antonio
Lofego, Antônio C.
Marques, Antonio C.
Macedo, Antonio
Andriolo, Artur
Henriques, Augusto L.
Ferreira Júnior, Augusto L.
Lima, Aurino F. de
Barros, Ávyla R. de A.
Brito, Ayrton do R.
Romera, Bárbara L.V.
Vasconcelos, Beatriz M.C. de
Frable, Benjamin W.
Santos, Bernardo F.
Ferraz, Bernardo R.
Rosa, Brunno B.
Sampaio, Brunno H.L.
Bellini, Bruno C.
Clarkson, Bruno
Oliveira, Bruno G. de
Corrêa, Caio C.D.
Martins, Caleb C.
Castro-Guedes, Camila F. de
Souto, Camilla
Bicho, Carla de L.
Cunha, Carlo M.
Barboza, Carlos A. de M.
Lucena, Carlos A.S. de
Barreto, Carlos
Santana, Carlos D.C.M. de
Agne, Carlos E.Q.
Mielke, Carlos G.C.
Caetano, Carlos H.S.
Flechtmann, Carlos H.W.
Lamas, Carlos J.E.
Rocha, Carlos
Mascarenhas, Carolina S.
Margaría, Cecilia B.
Waichert, Cecilia
Digiani, Celina
Haddad, Célio F.B.
Azevedo, Celso O.
Benetti, Cesar J.
Santos, Charles M.D. dos
Bartlett, Charles R.
Bonvicino, Cibele
Ribeiro-Costa, Cibele S.
Santos, Cinthya S.G.
Justino, Cíntia E.L.
Canedo, Clarissa
Bonecker, Claudia C.
Santos, Cláudia P.
Carvalho, Claudio J.B. de
Gonçalves, Clayton C.
Galvão, Cleber
Costa, Cleide
Oliveira, Cléo D.C. de
Schwertner, Cristiano F.
Andrade, Cristiano L.
Pereira, Cristiano M.
Sampaio, Cristiano
Dias, Cristina de O.
Lucena, Daercio A. de A.
Manfio, Daiara
Amorim, Dalton de S.
Queiroz, Dalva L. de
Queiroz, Dalva L. de
Colpani, Daniara
Abbate, Daniel
Aquino, Daniel A.
Burckhardt, Daniel
Cavallari, Daniel C.
Prado, Daniel de C. Schelesky
Praciano, Daniel L.
Basílio, Daniel S.
Bená, Daniela de C.
Toledo, Daniela G.P. de
Takiya, Daniela M.
Fernandes, Daniell R.R.
Ament, Danilo C.
Cordeiro, Danilo P.
Silva, Darliane E.
Pollock, Darren A.
Muniz, David B.
Gibson, David I.
Nogueira, David S.
Marques, Dayse W.A.
Lucatelli, Débora
Garcia, Deivys M.A.
Baêta, Délio
Ferreira, Denise N.M.
Rueda-Ramírez, Diana
Fachin, Diego A.
Souza, Diego de S.
Rodrigues, Diego F.
Pádua, Diego G. de
Barbosa, Diego N.
Dolibaina, Diego R.
Amaral, Diogo C.
Chandler, Donald S.
Maccagnan, Douglas H.B.
Caron, Edilson
Carvalho, Edrielly
Adriano, Edson A.
Abreu Júnior, Edson F. de
Pereira, Edson H.L.
Viegas, Eduarda F.G.
Carneiro, Eduardo
Colley, Eduardo
Eizirik, Eduardo
Santos, Eduardo F. dos
Shimbori, Eduardo M.
Suárez-Morales, Eduardo
Arruda, Eliane P. de
Chiquito, Elisandra A.
Lima, Élison F.B.
Castro, Elizeu B. de
Orlandin, Elton
Nascimento, Elynton A. do
Razzolini, Emanuel
Gama, Emanuel R.R.
Araujo, Enilma M. de
Nishiyama, Eric Y.
Spiessberger, Erich L.
Santos, Érika C.L. dos
Contreras, Eugenia F.
Galati, Eunice A.B.
Oliveira Junior, Evaldo C. de
Gallardo, Fabiana
Hernandes, Fabio A.
Lansac-Tôha, Fábio A.
Pitombo, Fabio B.
Dario, Fabio Di
Santos, Fábio L. dos
Mauro, Fabio
Nascimento, Fabio O. do
Olmos, Fabio
Amaral, Fabio R.
Schunck, Fabio
Godoi, Fábio S. P. de
Machado, Fabrizio M.
Barbo, Fausto E.
Agrain, Federico A.
Ribeiro, Felipe B.
Moreira, Felipe F.F.
Barbosa, Felipe F.
Silva, Fenanda S.
Cavalcanti, Fernanda F.
Straube, Fernando C.
Carbayo, Fernando
Carvalho Filho, Fernando
Zanella, Fernando C.V.
Jacinavicius, Fernando de C.
Farache, Fernando H.A.
Leivas, Fernando
Dias, Fernando M.S.
Mantellato, Fernando
Vaz-de-Mello, Fernando Z.
Gudin, Filipe M.
Albuquerque, Flávio
Molina, Flavio B.
Passos, Flávio D.
Shockley, Floyd W.
Pinheiro, Francielly F.
Mello, Francisco de A.G. de
Nascimento, Francisco E. de L.
Franco, Francisco L.
Oliveira, Francisco L. de
Melo, Francisco T. de V.
Quijano, Freddy R.B.
Salles, Frederico F.
Biffi, Gabriel
Queiroz, Gabriel C.
Bizarro, Gabriel L.
Hrycyna, Gabriela
Leviski, Gabriela
Powell, Gareth S.
Santos, Geane B. dos
Morse, Geoffrey E.
Brown, George
Mattox, George M.T.
Zimbrão, Geraldo
Carvalho, Gervásio S.
Miranda, Gil F.G.
Moraes, Gilberto J. de
Lourido, Gilcélia M.
Neves, Gilmar P.
Moreira, Gilson R.P.
Montingelli, Giovanna G.
Maurício, Giovanni N.
Marconato, Gláucia
Lopez, Guilherme E.L.
Silva, Guilherme L. da
Muricy, Guilherme
Brito, Guilherme R.R.
Garbino, Guilherme S.T.
Flores, Gustavo E.
Graciolli, Gustavo
Libardi, Gustavo S.
Proctor, Heather C.
Gil-Santana, Helcio R.
Varella, Henrique R.
Escalona, Hermes E.
Schmitz, Hermes J.
Rodrigues, Higor D.D.
Galvão Filho, Hilton de C.
Quintino, Hingrid Y.S.
Pinto, Hudson A.
Rainho, Hugo L.
Miyahira, Igor C.
Gonçalves, Igor de S.
Martins, Inês X.
Cardoso, Irene A.
Oliveira, Ismael B. de
Franz, Ismael
Fernandes, Itanna O.
Golfetti, Ivan F.
S. Campos-Filho, Ivanklin
Oliveira, Ivo de S.
Delabie, Jacques H.C.
Oliveira, Jader de
Prando, Jadila S.
Patton, James L.
Bitencourt, Jamille de A.
Silva, Janaina M.
Santos, Jandir C.
Arruda, Janine O.
Valderrama, Jefferson S.
Dalapicolla, Jeronymo
Oliveira, Jéssica P.
Hájek, Jiri
Morselli, João P.
Narita, João P.
Martin, João P.I.
Grazia, Jocélia
McHugh, Joe
Cherem, Jorge J.
Farias Júnior, José A.S.
Fernandes, Jose A.M.
Pacheco, José F.
Birindelli, José L.O.
Rezende, José M.
Avendaño, Jose M.
Duarte, José M. Barbanti
Ribeiro, José R. Inácio
Mermudes, José R.M.
Pujol-Luz, José R.
Santos, Josenilson R. dos
Câmara, Josenir T.
Teixeira, Joyce A.
Prado, Joyce R. do
Botero, Juan P.
Almeida, Julia C.
Kohler, Julia
Gonçalves, Julia P.
Beneti, Julia S.
Donahue, Julian P.
Alvim, Juliana
Almeida, Juliana C.
Segadilha, Juliana L.
Wingert, Juliana M.
Barbosa, Julianna F.
Ferrer, Juliano
Santos, Juliano F. dos
Kuabara, Kamila M.D.
Nascimento, Karine B.
Schoeninger, Karine
Campião, Karla M.
Soares, Karla
Zilch, Kássia
Barão, Kim R.
Teixeira, Larissa
Sousa, Laura D. do N.M. de
Dumas, Leandro L.
Vieira, Leandro M.
Azevedo, Leonardo H.G.
Carvalho, Leonardo S.
Souza, Leonardo S. de
Rocha, Leonardo S.G.
Bernardi, Leopoldo F.O.
Vieira, Letícia M.
Johann, Liana
Salvatierra, Lidianne
Oliveira, Livia de M.
Loureiro, Lourdes M.A. El-moor
Barreto, Luana B.
Barros, Luana M.
Lecci, Lucas
Camargos, Lucas M. de
Lima, Lucas R.C.
Almeida, Lucia M.
Martins, Luciana R.
Marinoni, Luciane
Moura, Luciano de A.
Lima, Luciano
Naka, Luciano N.
Miranda, Lucília S.
Salik, Lucy M.
Bezerra, Luis E.A.
Silveira, Luis F.
Campos, Luiz A.
Castro, Luiz A.S. de
Pinho, Luiz C.
Silveira, Luiz F.L.
Iniesta, Luiz F.M.
Tencatt, Luiz F.C.
Simone, Luiz R.L.
Malabarba, Luiz R.
Cruz, Luiza S. da
Sekerka, Lukas
Barros, Lurdiana D.
Santos, Luziany Q.
Skoracki, Maciej
Correia, Maira A.
Uchoa, Manoel A.
Andrade, Manuella F.G.
Hermes, Marcel G.
Miranda, Marcel S.
Araújo, Marcel S. de
Monné, Marcela L.
Labruna, Marcelo B.
Santis, Marcelo D. de
Duarte, Marcelo
Knoff, Marcelo
Nogueira, Marcelo
Britto, Marcelo R. de
Melo, Marcelo R.S. de
Carvalho, Marcelo R. de
Tavares, Marcelo T.
Kitahara, Marcelo V.
Justo, Marcia C.N.
Botelho, Marcia J.C.
Couri, Márcia S.
Borges-Martins, Márcio
Felix, Márcio
Oliveira, Marcio L. de
Bologna, Marco A.
Gottschalk, Marco S.
Tavares, Marcos D.S.
Lhano, Marcos G.
Bevilaqua, Marcus
Santos, Marcus T.T.
Domingues, Marcus V.
Sallum, Maria A.M.
Digiani, María C.
Santarém, Maria C.A.
Nascimento, Maria C. do
Becerril, María de los A.M.
Santos, Maria E.A. dos
Passos, Maria I. da S. dos
Felippe-Bauer, Maria L.
Cherman, Mariana A.
Terossi, Mariana
Bartz, Marie L.C.
Barbosa, Marina F. de C.
Loeb, Marina V.
Cohn-Haft, Mario
Cupello, Mario
Martins, Marlúcia B.
Christofersen, Martin L.
Bento, Matheus
Rocha, Matheus dos S.
Martins, Maurício L.
Segura, Melissa O.
Cardenas, Melissa Q.
Duarte, Mércia E.
Ivie, Michael A.
Mincarone, Michael M.
Borges, Michela
Monné, Miguel A.
Casagrande, Mirna M.
Fernandez, Monica A.
Piovesan, Mônica
Menezes, Naércio A.
Benaim, Natalia P.
Reategui, Natália S.
Pedro, Natan C.
Pecly, Nathalia H.
Ferreira Júnior, Nelson
Silva Júnior, Nelson J. da
Perioto, Nelson W.
Hamada, Neusa
Degallier, Nicolas
Chao, Ning L.
Ferla, Noeli J.
Mielke, Olaf H.H.
Evangelista, Olivia
Shibatta, Oscar A.
Oliveira, Otto M.P.
Albornoz, Pablo C.L.
Dellapé, Pablo M.
Gonçalves, Pablo R.
Shimabukuro, Paloma H.F.
Grossi, Paschoal
Rodrigues, Patrícia E. da S.
Lima, Patricia O.V.
Velazco, Paul
Santos, Paula B. dos
Araújo, Paula B.
Silva, Paula K.R.
Riccardi, Paula R.
Garcia, Paulo C. de A.
Passos, Paulo G.H.
Corgosinho, Paulo H.C.
Lucinda, Paulo
Costa, Paulo M.S.
Alves, Paulo P.
Roth, Paulo R. de O.
Coelho, Paulo R.S.
Duarte, Paulo R.M.
Carvalho, Pedro F. de
Gnaspini, Pedro
Souza-Dias, Pedro G.B.
Linardi, Pedro M.
Bartholomay, Pedro R.
Demite, Peterson R.
Bulirsch, Petr
Boll, Piter K.
Pereira, Rachel M.M.
Silva, Rafael A.P.F.
Moura, Rafael B. de
Boldrini, Rafael
Silva, Rafaela A. da
Falaschi, Rafaela L.
Cordeiro, Ralf T.S.
Mello, Ramon J.C.L.
Singer, Randal A.
Querino, Ranyse B.
Heleodoro, Raphael A.
Castilho, Raphael de C.
Constantino, Reginaldo
Guedes, Reinaldo C.
Carrenho, Renan
Gomes, Renata S.
Gregorin, Renato
Machado, Renato J.P.
Bérnils, Renato S.
Capellari, Renato S.
Silva, Ricardo B.
Kawada, Ricardo
Dias, Ricardo M.
Siewert, Ricardo
Brugnera, Ricaro
Leschen, Richard A.B.
Constantin, Robert
Robbins, Robert
Pinto, Roberta R.
Reis, Roberto E. dos
Ramos, Robson T. da C.
Cavichioli, Rodney R.
Barros, Rodolfo C. de
Caires, Rodrigo A.
Salvador, Rodrigo B.
Marques, Rodrigo C.
Araújo, Rodrigo C.
Araujo, Rodrigo de O.
Dios, Rodrigo de V.P.
Johnsson, Rodrigo
Feitosa, Rodrigo M.
Hutchings, Roger W.
Lara, Rogéria I.R.
Rossi, Rogério V.
Gerstmeier, Roland
Ochoa, Ronald
Hutchings, Rosa S.G.
Ale-Rocha, Rosaly
Rocha, Rosana M. da
Tidon, Rosana
Brito, Rosangela
Pellens, Roseli
Santos, Sabrina R. dos
Santos, Sandra D. dos
Paiva, Sandra V.
Santos, Sandro
Oliveira, Sarah S. de
Costa, Sávio C.
Gardner, Scott L.
Leal, Sebastián A. Muñoz
Aloquio, Sergio
Bonecker, Sergio L.C.
Bueno, Sergio L. de S.
Almeida, Sérgio M. de
Stampar, Sérgio N.
Andena, Sérgio R.
Posso, Sergio R.
Lima, Sheila P.
Gadelha, Sian de S.
Thiengo, Silvana C.
Cohen, Simone C.
Brandão, Simone N.
Rosa, Simone P.
Ribeiro, Síria L.B.
Letana, Sócrates D.
Santos, Sonia B. dos
Andrade, Sonia C.S.
Dávila, Stephane
Vaz, Stéphanie
Peck, Stewart B.
Christo, Susete W.
Cunha, Suzan B.Z.
Gomes, Suzete R.
Duarte, Tácio
Madeira-Ott, Taís
Marques, Taísa
Roell, Talita
Lima, Tarcilla C. de
Sepulveda, Tatiana A.
Maria, Tatiana F.
Ruschel, Tatiana P.
Rodrigues, Thaiana
Marinho, Thais A.
Almeida, Thaís M. de
Miranda, Thaís P.
Freitas, Thales R.O.
Pereira, Thalles P.L.
Zacca, Thamara
Pacheco, Thaynara L.
Martins, Thiago F.
Alvarenga, Thiago M.
Carvalho, Thiago R. de
Polizei, Thiago T.S.
McElrath, Thomas C.
Henry, Thomas
Pikart, Tiago G.
Porto, Tiago J.
Krolow, Tiago K.
Carvalho, Tiago P.
Lotufo, Tito M. da C.
Caramaschi, Ulisses
Pinheiro, Ulisses dos S.
Pardiñas, Ulyses F.J.
Maia, Valéria C.
Tavares, Valeria
Costa, Valmir A.
Amaral, Vanessa S. do
Silva, Vera C.
Wolff, Vera R. dos S.
Slobodian, Verônica
Silva, Vinícius B. da
Espíndola, Vinicius C.
Costa-Silva, Vinicius da
Bertaco, Vinicius de A.
Padula, Vinícius
Ferreira, Vinicius S.
Silva, Vitor C.P. da
Piacentini, Vítor de Q.
Sandoval-Gómez, Vivian E.
Trevine, Vivian
Sousa, Viviane R.
Sant’Anna, Vivianne B. de
Mathis, Wayne N.
Souza, Wesley de O.
Colombo, Wesley D.
Tomaszewska, Wioletta
Wosiacki, Wolmar B.
Ovando, Ximena M.C.
Leite, Yuri L.R.








ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
4.
Toxicogenetic studies of an antileishmania nanomedicine based on Ocotea fasciculata, a plant of the Brazilian flora fasciculata
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Squarisi, Iara Silva
; Freitas, Karoline Soares de
; Nicolella, Heloiza Diniz
; Ozelin, Saulo Duarte
; Barbosa-Filho, José Maria
; Marquele-Oliveira, Franciane
; Berretta, Andresa Aparecida
; Tavares, Denise Crispim
.








Abstract The lignoid fraction (LF) of Ocotea fasciculata, which is rich in yangambin and its epimer, epi-yangambin, showed promising activity against Leishmania sp. Subsequently, LF was incorporated into a solid lipid nanoparticle (SLN) in order to increase its pharmacological efficacy and decrease toxicity. In this regard, the present study was carried out to evaluate the cytotoxic and toxicogenetic potential of LF and LF-SLN in mammalian cells in vitro and in vivo. The cytotoxic activity was evaluated in a non-tumor human cell line (GM07492A) and the toxicogenetic potential was assessed in vitro in a Chinese hamster lung fibroblast cell line (V79) and in Swiss mice. LF-SLN showed no cytotoxic effect at the highest concentration tested (5,000 µg/mL), while LF exhibited an IC50 equivalent to 1,047 ± 4.50 µg/mL. The frequencies of micronuclei observed in vitro and in vivo in mammalian cells treated with different concentrations of LF and LF-SLN did not differ significantly from the negative control group. Therefore, LF and LF-SLN did not show genotoxic or cytotoxic effects under the experimental conditions used. These results contribute to the development of a drug for the treatment of leishmaniasis that is more effective and safer for human health. (LF fasciculata epimer epiyangambin, epiyangambin epi yangambin, epi-yangambin sp Subsequently SLN (SLN toxicity regard LFSLN nontumor non tumor GM07492A GMA GM A (GM07492A V79 V (V79 mice 5,000 5000 5 000 (5,00 µg/mL, µgmL µg/mL , µg mL µg/mL) IC IC5 1047 1 047 1,04 450 4 50 4.5 group Therefore used health V7 (V7 5,00 500 00 (5,0 104 04 1,0 45 4. (V 5,0 0 (5, 10 1, 5, (5 (
Resumo A fração lignoide (LF) de Ocotea fasciculata, rica em yangambina e seu epímero, epi-yangambina, apresentou atividade promissora contra Leishmania sp. Posteriormente, a LF foi incorporada a uma nanopartícula lipídica sólida (SLN), visando aumentar a eficácia farmacológica e diminuir a toxicidade. Nesse sentido, o presente estudo foi realizado para avaliar o potencial citotóxico e toxicogenético de LF e LF-SLN em células de mamíferos in vitro e in vivo. A atividade citotóxica foi avaliada em linhagem celular humana não-tumoral (GM07492A) e o potencial toxicogenético in vitro foi avaliado em linhagem celular de fibroblastos pulmonares de hamster chinês (V79) e em camundongos Swiss. LF-SLN não apresentou efeito citotóxico na maior concentração testada, 5.000 µg/mL, enquanto LF apresentou IC50 equivalente a 1.047 ± 4,50 µg/mL. As frequências de micronúcleos observadas in vitro em células de mamíferos e in vivo tratadas com diferentes concentrações de LF e LF-SLN não diferiram significativamente do grupo controle negativo. Portanto, LF e LF-SLN não apresentaram efeitos genotóxicos e citotóxicos nas condições experimentais utilizadas. Esses resultados contribuem para o desenvolvimento de um medicamento para o tratamento da leishmaniose, mais eficaz e seguro para a saúde humana. (LF fasciculata epímero epiyangambina, epiyangambina epi yangambina, epi-yangambina sp Posteriormente SLN, SLN , (SLN) toxicidade sentido LFSLN nãotumoral tumoral GM07492A GMA GM (GM07492A V79 V (V79 Swiss testada 5000 5 000 5.00 µgmL µg mL µg/mL IC IC5 1047 1 047 1.04 450 4 50 4,5 negativo Portanto utilizadas leishmaniose (SLN V7 (V7 500 00 5.0 104 04 1.0 45 4, (V 0 5. 10 1.
5.
Relato de experiência: coprodução do programa Qualis-APS para melhoria da qualidade da Atenção Primária à Saúde em Brasília
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Santos, Leonor Maria Pacheco
; Scherer, Magda Duarte dos Anjos
; Furlanetto, Denise de Lima Costa
; Pedrosa, Claudia Mara
; Freitas, Maria Silvia Fruet de
; Leite, Thais Alessa
; Santos, Wallace Enrico Boaventura Gonçalves Dos
.







RESUMO Para incentivar melhorias na qualidade da Atenção Primária à Saúde em Brasília, a Secretaria de Estado de Saúde do Distrito Federal (SES-DF) instituiu o Programa Qualis-APS em 2019: uma coprodução entre profissionais da assistência, gestores, pesquisadores da Universidade de Brasília e Fundação Oswaldo Cruz. Ao envolver gestores e trabalhadores na concepção, coordenação, planejamento e execução, almejou-se promover engajamento e senso de pertencimento, pré-requisitos para tomar decisões baseadas em evidências. Objetivou-se descrever a concepção e implementação da sistemática de avaliação e etapas do primeiro ciclo avaliativo, concluído em 2022: I. Diagnóstico da estrutura das 165 Unidades Básicas de Saúde; II. Elaboração de padrões de qualidade para compor instrumentos de autoavaliação, com base em subsídios obtidos nas oficinas com 544 profissionais de saúde e usuários; III. Desenvolvimento da Plataforma Qualis-APS; IV. Autoavaliação das 603 Equipes de Saúde da Família/Saúde Bucal, 100 equipes das Gerências da Atenção Primária à Saúde e 59 Equipes dos Núcleos Ampliados de Saúde da Família e Atenção Básica na Plataforma; V. Planejamento e elaboração do Plano de Ação para Qualidade pelas equipes; VI. Avaliação in loco das unidades básicas, por pesquisadores externos; VII. Certificação das equipes pela SES-DF. A experiência do primeiro ciclo foi exitosa; o segundo está em andamento.
ABSTRACT To encourage improvements in the quality of Primary Health Care in Brasília, the Federal District Health Department established the Qualis-APS Program in 2019, a co-production between healthcare professionals, managers and researchers from the University of Brasília and the Fundação Oswaldo Cruz. By involving managers and workers in the design, coordination, planning and execution, the aim was to promote engagement and a sense of ownership, prerequisites for evidence-based decision-making. The aim is to describe the conception and implementation of the evaluative process and the stages of the first evaluation cycle, concluded in 2022. I. Diagnosis of the structure of all 165 Basic Health Units; II. Elaboration of quality standards to compose self-assessment instruments, based on subsidies obtained in workshops with 544 health professionals and users; III. Development of the Qualis-APS Platform; IV. Self-assessment of the 603 Family Health Teams/Oral Health Teams, 100 Primary Health Care Management Teams and 59 Teams from the Expanded Family Health and Primary Care Centers on the Platform; V. Planning and elaboration of the Action Plan for Quality, made by the teams; VI. On-site evaluation of the Basic Units, by external researchers; VII. Certification of teams by the Health Department. The experience of the first cycle was successful and the second cycle is ongoing now.
6.
Growth and production of wheat cultivars under water tensions in Cerrado soil
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Soares, Denise C.
; Bonfim-Silva, Edna M.
; Silva, Tonny J. A. da
; Anicésio, Éllen C. A.
; Duarte, Thiago F.
; Oliveira, Jakeline R.
.






Revista Brasileira de Engenharia Agrícola e Ambiental
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RESUMO O Brasil não é autossuficiente na produção de trigo (Triticum aestivum L.) e a expansão do cultivo para o cerrado mato-grossense, em sistema irrigado, constitui alternativa para aumentar a produção desse cereal. Assim, objetivou-se avaliar os efeitos das tensões de água no solo no crescimento e na produção de cultivares de trigo sob Oxisol de Cerrado. Os tratamentos foram arranjados em um esquema fatorial 3 × 5, com três cultivares de trigo (BRS 254, BRS 394 e BRS 264) e cinco tensões de água no solo (5, 15, 25, 35 e 45 kPa), usando um delineamento em blocos casualizados, com quatro repetições. O crescimento e produção do trigo mostraram melhor resposta na tensão de 5 kPa. A cultivar BRS 254 apresentou maior redução na produção de espigas e de grãos por espiga com o incremento das tensões de água no solo. Entre as cultivares, a BRS 264 produziu maior número de grãos por espiga nas tensões de 35 e 45 kPa. As cultivares de trigo BRS 254, BRS 394 e BRS 264 possuem alto requerimento de água. Entretanto, a cultivar BRS 264 apresenta maior crescimento e produção em condições de restrição de água no solo, podendo ser cultivada com um sistema de irrigação acionado com menor frequência, com menor gasto de água e energia.
ABSTRACT Brazil is not self-sufficient for the production of wheat (Triticum aestivum L.), and the expansion of cultivation to the Cerrado in the State of Mato Grosso, in an irrigated system, is an alternative solution to increase wheat production. This study aimed to evaluate the effects of soil water tension on the growth and production of wheat cultivars cultivated in the Cerrado Oxisol. The treatments were arranged in a 3 × 5 factorial scheme, with three wheat cultivars (BRS 254, BRS 394, and BRS 264) and five water tensions in soil (5, 15, 25, 35, and 45 kPa), using a randomized block design with four replications. Wheat growth and production exhibited a better response at a tension of 5 kPa. Cultivar BRS 254 showed the lowest production of spikes and grains per spike with increasing soil water tension. Among the cultivars, BRS 264 produced the highest number of grains per spike at tensions of 35 and 45 kPa. The wheat cultivars BRS 254, BRS 394, and BRS 264 have high water requirements. However, BRS 264 presented greater growth and production under conditions of restricted water in the soil, being able to be cultivated with an irrigation system activated less frequently, with less expenditure of water and energy.
7.
Teenage pregnancy in the first year of the COVID-19 pandemic in Brazil COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Monteiro, Denise Leite Maia
; Monteiro, Ida Peréa
; Machado, Márcia Sacramento Cunha
; Bruno, Zenilda Vieira
; Silveira, Filomena Aste da
; Rehme, Marta Francis Benevides
; Takiuti, Albertina Duarte
; Rodrigues, Nádia Cristina Pinheiro
.








8.
O benefício do mascaramento modulado nos potenciais evocados auditivos corticais com estímulo de fala
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Rocha, Mônyka Ferreira Borges
; Menezes, Denise Costa
; Duarte, Danielle Samara Bandeira
; Griz, Silvana Maria Sobral
; Frizzo, Ana Claudia Figueiredo
; Menezes, Pedro de Lemos
; Teixeira, Cleide Fernandes
; Advíncula, Karina Paes
.








RESUMO Objetivo analisar o efeito do mascaramento estável e modulado no Potencial Evocado Auditivo Cortical com estímulo de fala em adultos-jovens. Método participaram 14 indivíduos com idades entre 19 e 28 anos de ambos os sexos e sem perda auditiva. O exame de Potencial Evocado Auditivo Cortical foi realizado com estímulo de fala sintética /ba/ simultâneo ao ruído Speech Shaped Noise apresentado em três condições: ruído estável com intensidade de 30 dB NPSpe (ruído estável fraco), ruído estável com intensidade de 65 dB NPSpe (ruído estável forte) e ruído modulado em intensidade de 30 dB NPSpe e 65 dB NPSpe em 25Hz e com período de modulação de 40 ms. Resultados foram observadas maiores latências nos componentes corticais, exceto P2, na condição de ruído estável forte e medidas mais robustas de amplitude dos componentes corticais P1, N1 e P2 na condição de ruído modulado com diferença estatística significativa na comparação com a condição de ruído estável forte. Houve pior morfologia na condição de ruído estável forte, quando comparado aos demais registros. Os limiares eletrofisiológicos médios para as condições de ruído estável forte e ruído modulado foram 60 dB NPSpe e 49 dB NPSpe, respectivamente, mostrando 11,7 dB de diferença média. Conclusão podemos inferir que houve um menor efeito mascarante do ruído modulado, comparado à condição de ruído estável forte, nas medidas de amplitude dos componentes corticais e uma diferença média de 11,7 dB entre os limiares eletrofisiológicos (interpretado como a medida do Benefício do Mascaramento Modulado).
ABSTRACT Purpose To analyze the effect of masking on the Cortical Auditory Evoked Potential with speech stimulus in young adults. Methods Fourteen individuals aged between 19 and 28 years of both sexes with no hearing loss participated in the study. The Cortical Auditory Evoked Potential examination was performed with synthetic speech stimulus /ba/ simultaneous to Speech Shaped Noise presented under three conditions: steady noise with a 30 dB SPLep intensity (weak steady noise), steady noise with a 65 dB SPLep intensity o (strong steady noise) and modulated noise with 30 dB SPLep and 65 dB SPLep intensities at 25Hz and modulation period of 40 ms. Results Higher latencies were observed in the cortical components, except P2, in the condition of strong steady noise and more meaningful measures of amplitude of the cortical components P1, N1 and P2 in the condition of modulated noise with statistically significant difference in comparison to the strong steady noise condition. There was worse wave morphology in the condition of strong steady noise, when compared to the other records. The average electrophysiological thresholds for the conditions of strong steady noise and modulated noise were 60 dB SPLep and 49 dB SPLep, respectively, showing a 11.7 dB mean difference. Conclusion We could infer that there was a lower masking effect of modulated noise when compared to the strong steady noise condition, in the amplitude measurements of the cortical components and an average difference of 11.7 dB between the electrophysiological thresholds (interpreted as the measure of the Masking Release).
9.
Diretriz Brasileira de Dispositivos Cardíacos Eletrônicos Implantáveis – 2023 202 20 2
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Teixeira, Ricardo Alkmim
; Fagundes, Alexsandro Alves
; Baggio Junior, José Mário
; Oliveira, Júlio César de
; Medeiros, Paulo de Tarso Jorge
; Valdigem, Bruno Pereira
; Teno, Luiz Antônio Castilho
; Silva, Rodrigo Tavares
; Melo, Celso Salgado de
; Elias Neto, Jorge
; Moraes Júnior, Antonio Vitor
; Pedrosa, Anisio Alexandre Andrade
; Porto, Fernando Mello
; Brito Júnior, Hélio Lima de
; Souza, Thiago Gonçalves Schroder e
; Mateos, José Carlos Pachón
; Moraes, Luis Gustavo Belo de
; Forno, Alexander Romeno Janner Dal
; D’Avila, Andre Luiz Buchele
; Cavaco, Diogo Alberto de Magalhães
; Kuniyoshi, Ricardo Ryoshim
; Pimentel, Mauricio
; Camanho, Luiz Eduardo Montenegro
; Saad, Eduardo Benchimol
; Zimerman, Leandro Ioschpe
; Oliveira, Eduardo Bartholomay
; Scanavacca, Mauricio Ibrahim
; Martinelli Filho, Martino
; Lima, Carlos Eduardo Batista de
; Peixoto, Giselle de Lima
; Darrieux, Francisco Carlos da Costa
Duarte, Jussara de Oliveira Pinheiro
Galvão Filho, Silas dos Santos
Costa, Eduardo Rodrigues Bento
Mateo, Enrique Indalécio Pachón
Melo, Sissy Lara De
Rodrigues, Thiago da Rocha
Rocha, Eduardo Arrais
Hachul, Denise Tessariol
Lorga Filho, Adalberto Menezes
Nishioka, Silvana Angelina D’Orio
Gadelha, Eduardo Barreto
Costa, Roberto
Andrade, Veridiana Silva de
Torres, Gustavo Gomes
Oliveira Neto, Nestor Rodrigues de
Lucchese, Fernando Antonio
Murad, Henrique
Wanderley Neto, José
Brofman, Paulo Roberto Slud
Almeida, Rui M. S.
Leal, João Carlos Ferreira






























10.
Colonization dynamics of subgingival microbiota in recently installed dental implants compared to healthy teeth in the same individual: a 6-month prospective observational study
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SILVA-BOGHOSSIAN, Carina Maciel
; DUARTE, Pablo Torquilho
; SILVA, Denise Gome da
; LOURENÇO, Talita Gomes Baêta
; COLOMBO, Ana Paula Vieira
.





Abstract Objectives To evaluate the colonization dynamics of subgingival microbiota established over six months around newly installed dental implants in periodontally healthy individuals, compared with their corresponding teeth. Methodology Seventeen healthy individuals assigned to receive single dental implants participated in the study. Subgingival biofilm was sampled from all implant sites and contralateral/ antagonist teeth on days 7, 30, 90, and 180 after implant installation. Microbiological analysis was performed using the Checkerboard DNA-DNA hybridization technique for detection of classical oral taxa and non-oral microorganisms. Significant differences were estimated by Mann-Whitney and Friedman tests, while associations between implants/teeth and target species levels were assessed by linear regression analysis (LRA). Significance level was set at 5%. Results Levels of some species were significantly higher in teeth compared to implants, respectively, at day 7 ( V.parvula , 6 × 10 5 vs 3 × 105 ; Milleri streptococci , 2 × 10 6 vs 6 × 10 5 ; Capnocytophaga spp., 2 × 10 6 vs 9 × 10 5 ; E.corrodens , 2 × 10 6 vs 5 × 10 5 ; N. mucosa , 2 × 10 6 vs 5 × 10 5 ; S.noxia , 2 × 10 6 vs 3 × 10 5 ; T.socranskii , 2 × 10 6 vs 5 × 10 5 ; H.alvei , 4 × 10 5 vs 2 × 10 5 ; and Neisseria spp., 6 × 10 5 vs 4 × 10 4 ), day 30 ( V.parvula , 5 × 10 5 vs 10 5 ; Capnocytophaga spp., 1.3 × 10 6 vs 6.8 × 10 4 ; F.periodonticum , 2 × 10 6 vs 10 6 ; S.noxia , 6 × 10 5 vs 2 × 10 5 ; H.alvei , 8 × 10 5 vs 9 × 10 4 ; and Neisseria spp., 2 × 10 5 vs 10 6 ), day 120 ( V.parvula , 8 × 10 5 vs 3 × 10 5 ; S.noxia , 2 × 10 6 vs 0; and T.socranskii , 3 × 10 5 vs 8 × 10 4 ), and day 180 ( S.enterica subsp. enterica serovar Typhi, 8 × 10 6 vs 2 × 10 6 ) (p<0.05). Implants showed significant increases over time in the levels of F.nucleatum , Gemella spp., H.pylori , P.micra , S.aureus , S.liquefaciens , and T.forsythia (p<0.05). LRA found that dental implants were negatively correlated with high levels of S. noxia and V. parvula (β=-0.5 to -0.3; p<0.05). Conclusions Early submucosal microbiota is diverse and only a few species differ between teeth and implants in the same individual. Only 7 days after implant installation, a rich microbiota can be found in the peri-implant site. After six months of evaluation, teeth and implants show similar prevalence and levels of the target species, including known and new periodontopathic species.
11.
Impact of an educational intervention on standard precautions during the COVID-19 pandemic
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Angeloni, Natália Liberato Norberto
; Silva, Maria Heloísa do Nascimento
; Valle, Lomberto Ariel Romeu
; Sousa, Álvaro Francisco Lopes
; Valim, Marília Duarte
; Andrade, Denise de
; Fronteira, Inês
; Santos Junior, Aires Garcia dos
.








ABSTRACT Objective: To evaluate the impact of an educational intervention on the knowledge of nursing professionals regarding standard precautions. Methods: This is an almost experimental study conducted with 100 nursing professionals. Data collection was performed using a sociodemographic characterization instrument and the Standard Precautions Knowledge Questionnaire. The educational intervention was based on five moments, where the approach to questions with less than 70% accuracy was intensified. Results: There was a significant difference between the scores of healthcare professionals before (16.20 ± 1.51) and after (16.90 ± 1.31) the educational intervention (W=3.336; p < 0.05). Regarding knowledge about hand hygiene after glove use, an increase in knowledge from 83% to 93% was obtained. Conclusions: A positive effect on the professionals’ knowledge was recorded, demonstrating advances regarding the strengthening of already acquired knowledge and the understanding of new knowledge.
RESUMO Objetivo: avaliar o impacto de uma intervenção educativa no conhecimento dos profissionais de enfermagem em relação às precauções padrão. Métodos: trata-se de um estudo quase-experimental, realizada com 100 profissionais de enfermagem. Para a coleta de dados, foram utilizados o instrumento de caracterização sociodemográfica e o questionário de Conhecimento das Precauções-Padrão. A intervenção educativa foi baseada em 05 momentos, onde se intensificou a abordagem em questões com menos de 70% de acerto. Resultados: Houve diferença significativa entre os escores dos profissionais de saúde antes (16,20 ± 1,51) e após (16,90 ± 1,31) a intervenção educativa (W=3,336; p < 0,05). Em relação ao conhecimento sobre a higiene das mãos após uso de luvas, obteve-se um aumento no conhecimento de 83% para 93%. Conclusões: registrou-se efeito positivo no conhecimento dos profissionais, demonstrando avanços no que diz respeito ao fortalecimento dos conhecimentos já adquiridos e à compreensão de novos saberes.
RESUMEN Objetivo: Evaluar el impacto de una intervención educativa en el conocimiento de los profesionales de enfermería sobre las precauciones estándar. Métodos: Este es un estudio cuasiexperimental realizado con 100 profesionales de enfermería. Para la recopilación de datos, se utilizaron un instrumento de caracterización sociodemográfica y el cuestionario de Conocimiento de las Precauciones Estándar. La intervención educativa se basó en cinco momentos, en los cuales se intensificó el abordaje de cuestiones con menos del 70% de aciertos. Resultados: Hubo una diferencia significativa entre las puntuaciones de los profesionales de salud antes (16,20 ± 1,51) y después (16,90 ± 1,31) de la intervención educativa (W = 3,336; p <0,05). En relación con el conocimiento sobre la higiene de las manos después del uso de guantes, se obtuvo un aumento en el conocimiento del 83% al 93%. Conclusiones: Se registró un efecto positivo en el conocimiento de los profesionales, demostrando avances en cuanto al fortalecimiento de los conocimientos ya adquiridos y la comprensión de nuevos saberes.
12.
In silico ADMET prediction, evaluation of cytotoxicity in mouse splenocytes and preliminary evaluation of in vitro antimalarial activity of 4-(4-chlorophenyl)thiazole compounds
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SILVA, BEATRIZ R.M.G. DA
; BEZERRA JÚNIOR, NATANAEL DA SILVA
; OLIVEIRA, JAMERSON F. DE
; DUARTE, DENISE MARIA F.A.
; MARQUES, DIEGO S.C.
; NOGUEIRA, FÁTIMA
; LIMA, MARIA CARMO A. DE
; CRUZ FILHO, IRANILDO JOSÉ DA
.








Anais da Academia Brasileira de Ciências
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Abstract In this work, an in silico study and evaluation of the cytotoxicity of 4-(4-chlorophenyl)thiazole compounds against mouse splenocytes and the chloroquine-sensitive Plasmodium falciparum 3D7 strain are reported. The in silico results showed that the compounds have important pharmacokinetic properties for compounds with potential drug candidates. Regarding cytotoxicity assays against splenocytes, the compounds have low cytotoxicity. In addition, they were able to promote activation of these cells by increasing nitric oxide production without promoting cell death. Finally, they were able to promote cell proliferation. Regarding the in vitro anti-P. falciparum activity assays, it was observed that the compounds were able to inhibit the parasite’s growth, presenting IC50 values ranging from 0.79 to greater than 10 µM. These results are promising when compared to chloroquine. Therefore, this study showed that 4-(4-chlorophenyl)thiazole compounds are promising candidates for antimalarials.
13.
The effect of noise on the amplitude and morphology of cortical auditory evoked potentials
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Duarte, Danielle Samara Bandeira
; Griz, Silvana Maria Sobral
; Rocha, Mônyka Ferreira Borges
; Britto, Diana Babini Lapa de Albuquerque
; Menezes, Denise Costa
; Advíncula, Karina Paes
.






Abstract Objective: To analyze the effect of noise on electrophysiological measurements (P1-N1-P2 complex) of cortical auditory evoked potentials in normal hearing individuals of different ages. Methods: The inclusion criteria for the study were young individuals, adults and elderly, aged 18–75 years, with auditory thresholds up to 25 dB. Participants were separated according to their age group: G1 (18–25 years old), G2 (31–59 years old) and G3 (60–75 years old). Cortical auditory evoked potentials were elicited with synthetic speech stimulus /da/ presented in two conditions: without masking and with masking (Delta-t 64ms). The results were expressed and analyzed using statistical measures. Results: High latencies and reduced amplitudes were observed in the Delta-t 64 ms condition, in all age groups. There were significant differences between the groups, both in P1 latencies for the two conditions and in N1 latencies in the Delta-t 64 ms condition. P1 latencies in the condition without masking were lower in G1 and P1 and N1 latencies in the Delta-t 64 ms condition were higher in G3. The described results show the influence of noise on cortical responses in all age groups, with G3 being the most affected by the masking presentation. Conclusion: The latency and amplitude measurements vary according to the stimulus presentation condition and age group. The forward masking phenomenon occurred with greater precision in G3. Level of evidence: (2c). Objective P1N1P2 PNP P2 P N (P1-N1-P complex ages Methods elderly 1875 18 75 18–7 2 dB group G 18–25 1825 (18–2 old, old , 31–59 3159 31 59 (31–5 60–75 6075 60 (60–7 old. . da /da Deltat Delta t 64ms. 64ms 64ms) measures Results 6 groups Conclusion evidence 2c. 2c c (2c) P1N1P 187 1 7 18– 18–2 182 (18– 31–5 315 3 5 (31– 60–7 607 (60– (2c (18 31– (31 60– (60 (1 (3 (6 (
14.
Urban climate adaptation: an interdisciplinary research experience empowering architecture and urbanism education
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Resumen Las ciudades del mundo están creciendo en tamaño y número. Al mismo tiempo, el cambio climático global eleva las temperaturas medias del planeta y aumenta los fenómenos meteorológicos extremos. Sao Paulo, la quinta región urbanizada del mundo, tiene actualmente más de 11 millones de habitantes y estudios recientes alertan sobre el aumento de la frecuencia de los eventos climáticos/ meteorológicos extremos en la ciudad. En este contexto, este trabajo presenta una experiencia de investigación interdisciplinaria, basada en la escuela de Arquitectura y Urbanismo en colaboración con el Departamento de Ciencias Atmosféricas, que aborda las interdependencias entre la morfología urbana, la infraestructura verde y el microclima en Sao Paulo, con el objetivo de discutir alternativas de planificación, diseño urbano y de edificios para contrarrestar los efectos del calentamiento urbano en un clima subtropical cambiante. El equipo de investigación, dirigido por un investigador de arquitectura y un investigador asociado de ciencias atmosféricas, incluye un investigador postdoctoral, estudiantes de grado y de posgrado, que se dedican a la arquitectura, el diseño urbano, la planificación y la meteorología y que tratan el papel de la planificación, el diseño urbano y de edificios para la adaptación al cambio climático. Este artículo resume brevemente lo que hemos aprendido con la teledetección, las mediciones y la simulación numérica, abarcando las escalas metropolitanas, de barrio y de edificio, y discute los resultados de una investigación interdisciplinaria que potencia la educación arquitectónica en diferentes niveles.
Abstract The world's cities are growing in size and number. At the same time, the global climate change rises global average temperatures as well as increase weather extreme events. Sao Paulo, the 5th urbanized region in the world, has currently more than 11 million inhabitants and recent studies alert for the increased frequency of extreme climate/weather events in the city. In this context, this work presents an interdisciplinary research experience, based at the Architecture and Urbanism school in partnership with the Atmospheric Sciences' Department, approaching the interdependences between urban morphology, green infrastructure, and microclimate in São Paulo, aiming to discuss planning, urban and building design alternatives to counterbalance urban warming effects in a subtropical changing climate. The research team, led by an architecture researcher and an associate researcher from atmospheric sciences, includes a post-doc researcher, graduate and undergraduate students, engaging architecture, urban design, planning, and meteorology dealing with the role of planning, urban and building design for climate change adaptation. This paper briefly summarizes what we have learnt with remote sensing, measurements and numerical simulation encompassing the metropolitan, the neighbourhood and the building scales and discuss the results of an interdisciplinary research empowering architectural education in different levels.
15.
Structure and responsiveness: are Primary Health Care Units prepared to face COVID-19?
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Furlanetto, Denise de Lima Costa
; Santos, Wallace Dos
; Scherer, Magda Duarte dos Anjos
; Cavalcante, Fabrício Vieira
; Oliveira, Aimê
; Oliveira, Klébya Hellen Dantas de
; Santos, Ricardo Ramos dos
; Leite, Thaís Alessa
; Poças, Katia Crestine
; Santos, Leonor Maria Pacheco
.










RESUMO A pandemia de Covid-19 reforçou a necessidade de esforços globais para garantir cobertura e acesso universal à saúde, impondo desafios na gestão da Atenção Primária à Saúde (APS). Este estudo objetivou desen- volver e aplicar um instrumento de avaliação da responsividade das Unidades Básicas de Saúde (UBS) diante da Covid-19, baseado na coprodução entre pesquisadores universitários e equipes técnicas da APS. O instrumento, dividido em dois módulos, incluiu identificação; horário de funcionamento; processo de trabalho; estrutura física, equipamentos, mobiliário, suprimentos e Equipamentos de Proteção Individual (EPI); atendimento, exames e acompanhamento de Usuários Sintomáticos Respiratórios (USR); vigilância, integração, comunicação e gestão. Todas as 165 UBS foram convidadas a completar o instrumento. Principais resultados: houve readequação da estrutura física (salas de espera, espaços internos/externos); fornecimento de EPI e de testes Covid-19, busca ativa de USR/suspeitos Covid-19 por telefone/visitas domiciliares, monitoramento de fluxos de transferência de pacientes e telessaúde. Concluindo, as UBS reorganizaram seus serviços para atender necessidades da pandemia. Fornecer informações sobre estrutura e capacidade de resposta das UBS pode subsidiar sistemas de saúde para planejamento e tomada de decisões, em diferentes níveis de gestão, crucial para determinar estratégias para reforçar a responsividade da APS em situações de pandemias e outras calamidades.
ABSTRACT The COVID-19 pandemic reinforced the need for global efforts to grant universal health coverage and access, which imposes management challenges for Primary Health Care (PHC). This study aimed to develop and apply an instrument to assess the PHC Units’ responsiveness to COVID-19, based on co-production efforts between university researchers and PHC technical teams. The instrument composed of two modules, included identification, operating hours, workforce, work process, structure, equipment, furniture, supplies, Personal Protection Equipment (PPE), Symptomatic Respiratory Patient (SRP) examinations and follow-up, information, surveillance, integration, communication, and management. All the 165 PHC Units in Brasília were invited to complete the instrument. Main results: there was physical structure adaptation (adequate configuration of waiting rooms, internal and external spaces allowing safe distance); provision of PPE and COVID-19 tests; active search for SRP/COVID-19 suspects by phone, mobile or home visits; monitoring flows of patient transfer and telehealth implementation. In conclusion, the PHC Units reorganized their services to meet the demands of the pandemic context. Providing information about structure and responsiveness of PHC Units may subside health systems for planning and decision-making at different levels of management, which is crucial to determine strategies to empower and reinforce PHC responsivity in situations of pandemics and other calamities.
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