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ABSTRACT Online hemodiafiltration (HDF) is a rapidly growing dialysis modality worldwide. In Brazil, the number of patients with private health insurance undergoing HDF has exceeded the number of patients on peritoneal dialysis. The achievement of a high convection volume was associated with better clinical imprand patient – reported outcomes confirming the benefits of HDF. The HDFit trial provided relevant practical information on the implementation of online HDF in dialysis centers in Brazil. This article aims to disseminate technical information to improve the quality and safety of this new dialysis modality.

RESUMO A hemodiafiltração (HDF) on-line é uma modalidade dialítica em rápido crescimento no mundo. No Brasil, o número de pacientes com planos de saúde privados tratados por HDF já ultrapassa aquele de pacientes em diálise peritoneal. O alcance de um alto volume convectivo associado à redução de desfechos clínicos e do risco de morte confirmam os benefícios da HDF. Dados nacionais do estudo HDFit forneceram informações práticas relevantes sobre a implementação da HDF on-line em clínicas de diálise no Brasil. O objetivo desta publicação é a disseminação de informações técnicas que possam auxiliar na utilização, com qualidade e segurança, dessa nova modalidade dialítica.

https://doi.org/10.1590/2175-8239-jbn-2023-0104en

Prediction and reasons for COVID-19 second dose vaccine hesitation: a cross-sectional study in a municipality of Brazil
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Sartorão-Filho, Carlos Izaias

; Zoqui, Mariana Costa

; Duarte, Douglas Otomo

; Ribeiro, Edy Alyson

; Bisetto, Vinicius César Queiroz

; Cachoni, Lara Escobar Gavião

; Sartorão, Ana Luísa Varrone

; Terribile, Diogo Coutinho

; Mello, Beatriz Balsimelli de

; Sartorão-Neto, Carlos Izaias

; Mello, Roberto de

Sao Paulo Medical Journal

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2023, Volume 141 N. 3 elocation e202295

Abstract: En | Text: En | PDF: En

ABSTRACT BACKGROUND: Hesitation and refusal to take a second dose of the vaccine for coronavirus disease 19 (COVID-19) are prevalent. OBJECTIVES: We aimed to identify predictive factors for hesitation or refusal and describe groups with higher rates of vaccine hesitancy. DESIGN AND SETTING: A cross-sectional study in Assis City, Brazil. METHODS: The study included adults who passed the due date for taking the COVID-19 second dose vaccine. Participants were recruited in December 2021 using a mobile-based text message. Sociodemographic and clinical data and reasons for hesitance were collected. The outcome was the attitude towards completing the recommended second dose of the vaccine. Bivariate and multivariate Poisson analyses were performed to determine the adjusted predictors. RESULTS: Participants between 30–44 years of age had a 2.41 times higher prevalence of hesitation than those aged 18–29 years. In addition, people who had adverse events or previously had COVID-19 had 4.7 and 5.4 times higher prevalences of hesitation, respectively (P value < 0.05). CONCLUSION: We found a significant group of adults aged between 30–44 years who refused the second dose of the COVID-19 vaccine. Furthermore, those who reported adverse effects after the first dose and those who had COVID-19 previously were a significant group for refusal.

https://doi.org/10.1590/1516-3180.2022.0095.r1.06072022

Effect of fluoride gels with nano-sized sodium trimetaphosphate on the in vitro remineralization of caries lesions
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NAGATA, Mariana Emi

; DELBEM, Alberto Carlos Botazzo

; BÁEZ-QUINTERO, Liliana Carolina

; DANELON, Marcelle

; SAMPAIO, Caio

; MONTEIRO, Douglas Roberto

; WIEGAND, Annette

; PESSAN, Juliano Pelim

Journal of Applied Oral Science

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2023, Volume 31 elocation e20230155

Abstract: En | Text: En | PDF: En

Abstract Objective To evaluate the effects of fluoride (F) gels supplemented with micrometric or nano-sized sodium trimetaphosphate (TMPmicro and TMPnano, respectively) on the in vitro remineralization of caries-like lesions. Methodology Bovine enamel subsurface lesions (n=168) were selected according to their surface hardness (SH) and randomly divided into seven groups (n=24/group): Placebo (without F/TMP), 4,500 ppm F (4500F), 4500F + 2.5% TMPnano (2.5% Nano), 4500F + 5% TMPnano (5% Nano), 4500F + 5% TMPmicro (5% Micro), 9,000 ppm F (9000F), and 12,300 ppm F (Acid gel). The gels were applied in a thin layer for one minute. Half of the blocks were subjected to pH cycling for six days, whereas the remaining specimens were used for loosely- (calcium fluoride; CaF2) and firmly-bound (fluorapatite; FA) fluoride analysis. The percentage of surface hardness recovery (%SHR), area of subsurface lesion (ΔKHN), CaF2, FA, calcium (Ca), and phosphorus (P) on/in enamel were determined. Data (log10-transformed) were subjected to ANOVA and the Student-Newman-Keuls’ test (p<0.05). Results We observed a dose-response relation between F concentrations in the gels without TMP for %SHR and ΔKHN. The 2.5% Nano and 5% Micro reached similar %SHR when compared with 9000F and Acid gels. For ΔKHN, Placebo and 5% Nano gels had the highest values, and 5% Micro, 2.5% Nano, 9000F, and Acid gels, the lowest. All groups had similar retained CaF2 values, except for Placebo and Acid gel. We verified observed an increase in Ca concentrations in nano-sized TMP groups. Regarding P, TMP groups showed similar formation and retention to 9000F and Acid. Conclusion Adding 2.5% nano-sized or 5% micrometric TMP to low-fluoride gels lead to enhanced in vitro remineralization of artificial caries lesions.

https://doi.org/10.1590/1678-7757-2023-0115

Inflamação Coronária Avaliada pela Atenuação de Gordura Pericoronária na Tomografia Computadorizada e Elevação de Citocinas em Usuários Jovens de Esteroides Anabólicos Androgênicos
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Souza, Francis Ribeiro de

; Rochitte, Carlos E.

; Silva, Douglas Carli

; Sampaio, Barbara

; Passarelli, Marisa

; Santos, Marcelo R. dos

; Fonseca, Guilherme W.

; Battaglia Filho, Antonio Carlos

; Correa, Kelly

; do Val, Renata Margarida

; Yonamine, Maurício

; Pereira, Rosa Maria R.

; Negrão, Carlos Eduardo

; Kalil-Filho, Roberto

; Alves, Maria Janieire de Nazaré Nunes

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 11 elocation e20220822

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background Anabolic androgenic steroid (AAS) abuse has been associated with coronary artery disease (CAD). Pericoronary fat attenuation (pFA) is a marker of coronary inflammation, which is key in the atherosclerotic process. Objective To evaluate pFA and inflammatory profile in AAS users. Methods Twenty strength-trained AAS users (AASU), 20 AAS nonusers (AASNU), and 10 sedentary controls (SC) were evaluated. Coronary inflammation was evaluated by mean pericoronary fat attenuation (mPFA) in the right coronary artery (RCA), left anterior descending coronary artery (LAD), and left circumflex (LCx). Interleukin (IL)-1 (IL-1), IL-6, IL-10, and TNF-alpha were evaluated by optical density (OD) in a spectrophotometer with a 450 nm filter. P<0.05 indicated statistical significance. Results AASU had higher mPFA in the RCA (-65.87 [70.51-60.70] vs. -78.07 [83.66-72.87] vs.-78.46 [85.41-71.99] Hounsfield Units (HU), respectively, p<0.001) and mPFA in the LAD (-71.47 [76.40-66.61] vs. -79.32 [84.37-74.59] vs. -82.52 [88.44-75.81] HU, respectively, p=0.006) compared with AASNU and SC. mPFA in the LCx was not different between AASU, AASNU, and SC (-72.41 [77.17-70.37] vs. -80.13 [86.22-72.23] vs. -78.29 [80.63-72.29] HU, respectively, p=0.163). AASU compared with AASNU and SC, had higher IL-1, (0.975 [0.847-1.250] vs. 0.437 [0.311-0.565] vs. 0.530 [0.402-0.780] OD, respectively, p=0.002), IL-6 (1.195 [0.947-1.405] vs. 0.427 [0.377-0.577] vs. 0.605 [0.332-0.950] OD, p=0.005) and IL-10 (1.145 [0.920-1.292] vs. 0.477 [0.382-0.591] vs. 0.340 [0.316-0.560] OD, p<0.001). TNF-α was not different between the AASU, AASNU, and SC groups (0.520 [0.250-0.610] vs. 0.377 [0.261-0.548] vs. 0.350 [0.182-430]), respectively. Conclusion Compared with ASSNU and controls, AASU have higher mPFA and higher systemic inflammatory cytokines profile suggesting that AAS may induce coronary atherosclerosis through coronary and systemic inflammation.

Resumo Fundamento O uso abusivo de esteroides anabólicos androgênicos (EAA) tem sido associado à doença arterial coronariana (DAC). A atenuação de gordura pericoronária (AGp) é um marcador de inflamação coronária, a qual exerce um papel chave no processo aterosclerótico. Objetivo Avaliar AGp e perfil inflamatório em usuários de EAA. Método Vinte indivíduos que realizavam treinamento de força, usuários de EAA (UEAA), 20 não usuários de EAA (NUEAA), e 10 indivíduos sedentários controle (SC) foram avaliados. Inflamação coronária foi avaliada por atenuação de gordura pericoronária média (AGPm) artéria coronária direita (ACD), artéria descendente anterior esquerda (ADA) e artéria circunflexa (ACX). Interleucina (IL)-1 (IL-1), IL-6, IL-10, e TNF-alfa foram avaliados por densidade ótica (DO) em um espectrofotômetro com um filtro de 450 nm. Um p<0,05 indicou significância estatística. Resultados Os UEAA apresentaram maior AGPm na ACD [-65,87 (70,51-60,70) vs. -78,07 (83,66-72,87) vs.-78,46 (85,41-71,99] unidades Hounsfield (HU), respectivamente, p<0,001) e AGPm na ADA [-71,47 (76,40-66,610 vs. -79,32 (84,37-74,59) vs. -82,52 (88,44-75,81) HU, respectivamente, p=0,006) em comparação aos NUEAA e CS. A AGPm na ACX não foi diferente entre os grupos UEAA, NUEAA e CS [-72,41 (77,17-70,37) vs. -80,13 (86,22-72,23) vs. -78,29 (80,63-72,29) HU, respectivamente, p=0,163). Em comparação aos NUEAA e aos CS, o grupo UEAA apresentaram maiores níveis de IL-1 [0,975 (0,847-1,250) vs. 0,437 (0,311-0,565) vs. 0,530 (0,402-0,780) DO, respectivamente, p=0,002), IL-6 [1,195 (0,947-1,405) vs. 0,427 (0,377-0,577) vs. 0,605 (0,332-0,950) DO, p=0,005) e IL-10 [1,145 (0,920-1,292) vs. 0,477 (0,382-0,591) vs. 0,340 (0,316-0,560) DO, p<0,001]. TNF-α não foi diferente entre os grupos UEAA, NUEAA e CS [0,520 (0,250-0,610) vs. 0,377 (0.261-0,548) vs. 0,350 (0,182-430)]. Conclusão Em comparação aos NUEAA e controles, os UEAA apresentam maior AGPm e maior perfil de citocinas inflamatórias sistêmicas, sugerindo que os EAA podem induzir aterosclerose por inflamação coronária e sistêmica.

https://doi.org/10.36660/abc.20220822

Characterization of the nigroestriatal system in a sample of patients with amyotrophic lateral sclerosis
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Monsalve, Claudio Alejandro Jimenez

; Fornari, Luis Henrique Tieppo

; Silva Júnior, Neivo da

; Nakata, Douglas Tomio

; Carvalho Neto, Eurípedes Gomes de

; Rotta, Francisco Tellechea

; Rieder, Carlos Roberto de Mello

Arquivos de Neuro-Psiquiatria

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aug 2022, Volume 80 N. 8 Pages 806 - 811

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background The coexistence of amyotrophic lateral sclerosis (ALS) with clinical forms of Parkinson disease (PD), although uncommon, is found to a greater degree than one would expect by chance. The pathological mechanisms of ALS and PD are still not fully understood, and the coexistence of these two diseases suggests that they could share mechanisms in common. Objective Here we present a sample of patients with clinically definitive or probable ALS who were evaluated with single-photon emission computed tomography SPECT/TRODAT and compared with non-ALS controls. Methods Patients with clinically definite or probable ALS were assessed with the amyotrophic lateral sclerosis functional rating scale (ALSFRS) to define severity and had their demographic data collected. The TRODAT results of patients with ALS were compared with those of patients with a diagnosis of PD with less than 10 years of duration, and with patients with a diagnosis of others movement disorders not associated with neurodegenerative diseases. Results A total of 75% of patients with ALS had TRODAT results below the levels considered normal; that was also true for 25% of the patients in the control group without neurodegenerative disease, and for 100% of the patients in the PD group. A statistically significant difference was found between patients with ALS and the control group without neurodegenerative disease in the TRODAT values < 0.05. Conclusions Our study fits with the neuropathological and functional evidence that demonstrates the existence of nigrostriatal dysfunction in patients with ALS. Further research to better understand the role of these changes in the pathophysiological process of ALS needs to be performed.

Resumo Antecedentes A coexistência da esclerose lateral amiotrófica (ELA) com formas clínicas da doença de Parkinson (DP), embora incomum, é encontrada em um grau maior do que seria esperado ao acaso. Os mecanismos patológicos da ELA e da DP ainda não são totalmente compreendidos e a coexistência dessas duas doenças sugere que elas podem compartilhar mecanismos em comum. Objetivo Apresentamos uma amostra de pacientes com ELA clinicamente definida ou provável que foram avaliados com tomografia computadorizada por emissão de fóton único (SPECT)/TRODAT e comparados com controles sem ELA. Métodos Pacientes com ELA clinicamente definida ou provável foram avaliados com a escala funcional de esclerose lateral amiotrófica (ALSFRS) para definir a gravidade e foram coletados os seus dados demográficos. Os resultados do TRODAT de pacientes com ELA foram comparados com aqueles de pacientes com diagnóstico de DP com menos de 10 anos de duração e com pacientes com diagnóstico de outros distúrbios do movimento não associados a doenças neurodegenerativas. Resultados Um total de 75% dos pacientes com ELA apresentou resultados de TRODAT abaixo dos níveis considerados normais; 25% no grupo controle sem doença neurodegenerativa e 100% no grupo DP. Uma diferença estatisticamente significativa foi encontrada entre os pacientes com ELA e o grupo controle sem doença neurodegenerativa nos valores de TRODAT p< 0,05. Conclusões Nosso estudo está de acordo com as evidências neuropatológicas e funcionais que demonstram a existência de disfunção nigroestriatal em pacientes com ELA. Mais pesquisas para entender melhor o papel dessas mudanças no processo fisiopatológico da ELA precisam ser realizadas.

https://doi.org/10.1055/s-0042-1755282

Prediction and reasons for COVID-19 second dose vaccine hesitation: a cross-sectional study in a municipality of Brazil
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Sartorão-Filho, Carlos Izaias

; Zoqui, Mariana Costa

; Duarte, Douglas Otomo

; Ribeiro, Edy Alyson

; Bisetto, Vinicius César Queiroz

; Cachoni, Lara Escobar Gavião

; Sartorão, Ana Luísa Varrone

; Terribile, Diogo Coutinho

; Mello, Beatriz Balsimelli de

; Sartorão-Neto, Carlos Izaias

; Mello, Roberto de

Sao Paulo Medical Journal

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2022, N. ahead

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1516-3180.2022.0095.r1.06072022

Carbon stock and biomass estimate by additive models applied to Ilex paraguariensis
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Cunha Neto, Ernandes Macedo da

; Santana, Gabriel Mendes

; Araujo, Emmanoella Costa Guaraná

; Veras, Hudson Franklin Pessoa

; Marcos, Douglas Prado

; Friedrich, Flaviana

; Sanquetta, Carlos Roberto

Pesquisa Agropecuária Tropical

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2022, Volume 52 elocation e72966

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A erva-mate é um produto florestal não-madeireiro importante no Sul do Brasil, sendo cultivada junto com espécies nativas devido à sua necessidade de sombreamento, o que contribui para a conservação e fixação do carbono na sua biomassa. Contudo, a determinação da biomassa é difícil, pois as estimativas não garantem a aditividade entre os compartimentos e a biomassa total acima do solo. Objetivou-se avaliar modelo aditivo (seemingly unrelated regression - SUR) e não aditivo (ordinary least squares - OLS) de biomassa para um povoamento de erva-mate, além de comparar seu estoque de carbono com outros tipos de uso do solo, consolidando o seu potencial frente às mudanças climáticas. Um total de 30 árvores foram cortadas, compartimentadas e pesadas em balança digital, a fim de ajustar quatro modelos de biomassa. Os estoques de carbono foram comparados com valores encontrados na literatura. O viés do modelo SUR foi inferior a 2 %, exceto para as folhas, enquanto, no modelo OLS, variou entre 1 e 14 %. O erro variou entre 23 e 49 % para o SUR e entre 31 e 50 % para o OLS. Os modelos ajustados por SUR garantiram acurácia e aditividade dos compartimentos. O plantio de Ilex paraguariensis estocou mais carbono que áreas de agricultura e pasto, removendo mais gás CO2, evidenciando a sustentabilidade desse sistema e favorecendo a estabilidade climática.

ABSTRACT Ilex paraguariensis is an important non-timber forest product in southern Brazil, where it is cultivated in association with native species, given its demand for shading, which contributes to the conservation and carbon fixation in its biomass. However, determining this biomass is difficult, since the estimates do not guarantee additivity between the compartments and the total aboveground biomass. This study aimed to evaluate additive (seemingly unrelated regression - SUR) and non-additive (ordinary least squares - OLS) biomass models in an Ilex paraguariensis stand and comparing its carbon stock with other land use types, consolidating its potential in the face of climate change. A total of 30 trees were cut, compartmentalized and weighed on a digital scale, and four biomass models were adjusted. The carbon stocks were compared with values found in the literature. The bias in the SUR model was less than 2 %, except for the leaves, while the bias in the OLS model varied between 1 and 14 %. The error ranged between 23 and 49 % for SUR, and between 31 and 50 % for OLS. The models adjusted by SUR ensured the accuracy and additivity of the compartments. The Ilex paraguariensis stand stored more carbon than agriculture and pasture areas, removing more CO2, evidencing the sustainability of this system and favoring the climate stability.

https://doi.org/10.1590/1983-40632022v5272966

Consenso colombiano de expertos sobre recomendaciones informadas en la evidencia para la prevención, el diagnóstico y el manejo de la infección por SARS-CoV-2/COVID-19 en pacientes con Enfermedad Renal Crónica en diálisis
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Yomayusa González, Nancy

; Yama, Erika

; González, Camilo

; Ariza, Amaury

; Aroca, Gustavo

; Baquero, Richard

; Rico, Jorge

; Vargas, Juan Guillermo

; Ramirez, Roberto

; Chacón, Kelly

; Robayo, Adriana

; Peña Wilches, Adalberto

; Meza, Adriana

; Bunch, Alfonso

; Mercado, Alvaro

; Calderón, Angélica

; Wancjer, Benjamín

; Zambrano, Betty

; Lozano, Carlos

; Buitrago, Cristóbal

; Ballesteros, David

; Chacón, Diana

; Vargas, Diana

; Villafañe, Douglas

; López, Francisco

; Pinzón, Freddy

; Guerrero, Gustavo

; Cárdenas, Héctor

; Benavides, Helman

; Villanueva, Ignacio

; Raoch, Ingrid

; Cáceres, Jimena

; Coronado, Jorge

; Pulido, Jorge

; Contreras, Kateir

; Valderrama Cometa, Luis Alfonso

; Gómez, María

; Vargas Brochero, María José

; Carrascal, Martha

; Rodríguez, Martha

; Guerrero, Mauricio

; Alfaro Tejeda, Mercedes

; Tobón, Natalia

; Rodríguez, Paula

; Gómez, Rafael

; Daza, Rodrigo

; Torres, Rodolfo

; Espitaleta, Zilac

; Burgos, Álvaro

Revista Colombiana de Nefrología

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dec 2020, Volume 7 Suppl. 2 Pages 119 - 159

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción: Las personas con diálisis de mantenimiento se consideran una población en alto riesgo de infección por SARS-CoV-2, complicaciones y muerte. La periodicidad de la diálisis, la organización y la demanda en las unidades de diálisis y las limitaciones de alfabetización en salud poblacional limitan el cumplimiento del aislamiento y el distanciamiento social. Objetivo: Desarrollar, mediante un consenso de expertos, recomendaciones informadas en evidencia para la prevención, el diagnóstico y el manejo de la infección por SARS-CoV-2/COVID-19 en pacientes con enfermedad renal crónica. Materiales y métodos: Se realizó una revisión rápida de literatura en Pubmed, Embase y sociedades científicas. La calidad de evidencia fue evaluada según el tipo de estudio incluido. El acuerdo se definió para cada recomendación con umbral de al menos 70% de aprobación. La fuerza de las recomendaciones fue graduada como fuerte o débil. Resultados: El colectivo fue consultado entre el 17 y 19 de mayo de 2020. Se obtuvo respuesta de 44 expertos clínicos que declararon conflicto de interés previo a la consulta. El acuerdo de las recomendaciones estuvo entre 70,5 y 100%. Se presentan las recomendaciones de un colectivo experto para la prevención, el diagnóstico y el manejo de infección por SARS-CoV-2/COVID-19 en pacientes con enfermedad renal crónica. Conclusión: Debido a la reciente aparición de la infección por SARS-CoV-2 y las incertidumbres respecto a la prevención, el diagnóstico y el manejo, las recomendaciones presentadas se conciben como un estándar colombiano que permita garantizar un cuidado centrado en las personas con enfermedad renal crónica y la protección de los profesionales de la salud.

Abstract Introduction: People with chronic dialysis are considered a population at high risk of SARS CoV2 infection and its derived complications and death. The need to go to strict dialysis schedules, the high demand in the kidney facilities and the difficulties derived from the time and space organization in the rooms in the face to the pandemic added to the difficult learning, teaching and adapting new protocols manifest the needed of standard recommendation according to this problem in people who couldn't have an ideal isolation. Objective: Develop through an expert consensus, evidence-informed recommendations for the prevention, diagnosis, and management of SARS-CoV-2/COVID-19 infection in patients with chronic kidney disease on Dialysis. Materials and methods: We carried out a quick literature review, PubMed, Embase and scientific societies were consulted. The quality of the evidence was considered according to the type of study included. The agreement threshold defined for each recommendation was > 70% approval among experts. The strength of the recommendations was rated as strong or weak. Results: Between May 17 and 19, 2020, was conformed a team of 44 clinical experts who declared their interest conflict prior to the consultation. The agreement of the recommendations was between 70.5% and 100%. The recommendations were separated in prevention, early identification, and diagnostic, isolation in hemodialysis facilities and peritoneal dialysis, and team protection. Ethical considerations also were included. Conclusion: Due to the recent appearance of SARS-CoV-2 infection and the uncertainties regarding prevention, diagnosis and management, the recommendations presented are conceived as a Colombian standard that allows guaranteeing focused care for people with chronic kidney disease and the protection of health team.

https://doi.org/10.22265/acnef.7.supl.2.474 347 downloads

Consenso colombiano de expertos sobre recomendaciones informadas en la evidencia para la prevención, el diagnóstico y el manejo de la lesión renal aguda por SARS-CoV-2/COVID-19
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González, Camilo

; Yama, Erika

; Yomayusa, Nancy

; Vargas, Juan

; Rico, Jorge

; Ariza, Amaury

; Aroca, Gustavo

; Baquero, Richard

; Ramírez, Roberto

; Chacón, Kelly

; Torres, Rodolfo

; Robayo, Adriana

; Peña, Adalberto

; Meza, Adriana

; Molano, Alejandra

; Lizarazo, Alexandra

; Caicedo, Andrea

; Acevedo, Andrés

; Calderón, Angélica

; Zambrano, Betty

; Musso, Carlos Guido

; Lozano, Carlos

; Buitrago, Cristóbal

; Ballesteros, David

; Chacón, Diana

; Vargas, Diana

; Gayón, Diana

; Villafañe, Douglas

; López, Francisco

; Ardila, Freddy

; Pinzón, Guillermo

; Guerrero, Gustavo

; Benavides, Helman

; Villanueva, Ignacio

; Raoch, Ingrid

; Galeano, Javier

; Gordon, Jennifer

; Cáceres, Jimena

; Pulido, Jorge

; Pérez, Jorge

; Contreras, Kateir

; Aristizábal, Leidy

; Valderrama, Luis

; Gómez, María

; Vargas, María José

; Carrascal, Martha

; Rodríguez, Martha

; Guerrero, Mauricio

; Alfaro, Mercedes

; Tobón, Natalia

; García, Paola

; Rodríguez, Paula

; Daza, Rodrigo

; Espitaleta, Zilac

Revista Colombiana de Nefrología

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dec 2020, Volume 7 Suppl. 2 Pages 89 - 117

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

resumen está disponible en el texto completo

Abstract Introduction: Acute kidney injury is a frequent complication in patients with COVID-19 and its occurrence is a potential indicator of multi-organ dysfunction and disease severity. Objective: Develop, through an expert consensus, evidence-based recommendations for the prevention, diagnosis, and management of acute kidney injury in patients with SARS CoV2 / COVID-19 infection. Materials and methods: Based on a rapid systematic review in Embase and Pubmed databases and documents from scientific societies, we made preliminary recommendations and consulted with an expert group through an online tool. Then we defined agreement after at least 70 % consensus approval. Quality evidence was evaluated according to the type of document included. The strength of the recommendations was graded as strong or weak. Results: Fifty clinical experts declared their conflict of interest; the consultation took place between May 2 and 29, 2020. The range of agreement ranged from 75.5 % to 100 %. Recommendations for prevention, diagnosis and management of acute kidney injury in patients with SARS CoV2 infection are presented. Conclusions: Although the good quality information available regarding acute kidney injury in patients with COVID-19 is scarce, the recommendations of clinical experts will guide clinical decision-making and strategies around patients with this complication, guaranteeing care focused on the people, with high quality standards, and the generation of safety, health and wellness policies for multidisciplinary care teams.

https://doi.org/10.22265/acnef.7.supl.2.73 434 downloads

10.

Consenso colombiano de expertos sobre recomendaciones informadas en la evidencia para la prevención, diagnóstico y manejo de la infección por SARS-CoV-2/COVID-19 en paciente pediátrico con enfermedad renal crónica o lesión renal aguda asociada a COVID-19
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Baquero Rodriguez, Richard

; Yomayusa, Nancy

; Gonzalez, Camilo

; Yama, Erika

; Vargas, Juan Guillermo

; Rico, Jorge

; Ariza, Amaury

; Aroca, Gustavo

; Ramírez, Roberto

; Chacón, Kelly

; Torres, Rodolfo

; Robayo, Adriana

; Meza Martínez, Adriana Isabel

; Calderón Ortiz, Angélica María

; Zapata Chica, Carlos Andrés

; Morales Contreras, Carol Lisbeth

; Ochoa García, Carolina Lucía

; Pinto Bernai, Claudia

; Chacón Jaimes, Diana Carolina

; Villafañe Bermúdez, Douglas Ramón

; Suárez Barajas, Ehimy Marcela

; López, Franklin Atencia

; Guerrero Tinoco, Gustavo Adolfo

; Cáceres Mosquera, Jimena Adriana

; Cárdenas Aguilera, Juan Guillermo

; González, Luz Esthella

; Osorio Ruiz, María Franqueline

; Carrascal Guzmán, Martha Isabel

; Mejía Gaviria, Natalia

; Sierra Quiroz, Yusir

; Espitaleta, Zilac

; Beltrán, Sandra

Revista Colombiana de Nefrología

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dec 2020, Volume 7 Suppl. 2 Pages 50 - 69

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

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Abstract Introduction: The numbers of SARS-CoV-2 infection in the pediatric population are low so far. There is limited information about the behavior of SARS-CoV-2 in a pediatric patient with chronic kidney disease. Objective: To formulate informed recommendations to the prevention, diagnosis, and management of SARS-CoV-2 infection in pediatric patients with kidney disease or acute kidney injury associated with COVID-19 in Colombia. Methodology: A rapid systematic review was performed in Embase and Pubmed databases and scientific societies, to answer questions prioritized by clinical experts in pediatric nephrology. The quality of the evidence was evaluated with validated tools according to the type of study. The preliminary recommendations were consulted by an expert group. The agreement was defined when approval was obtained from at least 70% of the experts consulted. Results: A response was obtained from ' 9 experts in pediatric nephrology in Colombia, who declared the conflict of interest before the consultation. The range of agreement for the recommendations ranged from 78.9% to '00%. The recommendations did not require a second consultation. Conclusion: The evidence-based recommendations for the management of a patient with kidney disease and COVID-19 in the Colombian context are presented.

https://doi.org/10.22265/acnef.7.supl.2.488 635 downloads

11.

Solubility and availability of micronutrients extracted from silicate agrominerals
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Marchi, Giuliano

; Guelfi-Silva, Douglas Ramos

; Malaquias, Juaci Vitória

; Guilherme, Luiz Roberto Guimarães

; Spehar, Carlos Roberto

; Martins, Eder de Souza

Pesquisa Agropecuária Brasileira

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2020, Volume 55 elocation e00807

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: O objetivo deste trabalho foi avaliar a solubilidade dos micronutrientes cobre, níquel e zinco, extraídos quimicamente de agrominerais silicáticos, como fonte alternativa de potássio para as culturas de alface (Lactuca sativa) e arroz (Oryza sativa), bem como sua disponibilidade para as plantas. Avaliaram-se os teores de micronutrientes de cinco agrominerais (ultramáfica alcalina, biotita xisto, brecha vulcânica, flogopita xisto e subproduto de mineração de Chapada), após extração pelos métodos ácido cítrico, ácido clorídrico, ácido dietilenotriamino penta-acético, 3051A, citrato neutro de amônio e Mehlich 3. Os agrominerais, nas doses de 0 (controle), 200, 400 e 600 kg ha-1 de K, foram misturados em solo com cultivo de alface e arroz. Os agrominerais apresentaram baixa solubilidade de Ni, Cu e Zn, com menores teores em folhas de alface e grãos de arroz que o padrão solúvel correspondente na forma de sulfato. A disponibilidade de micronutrientes para as plantas aumentou com uso dos agrominerais, em comparação ao controle. Foram observadas similaridades na solubilidade e na disponibilidade de micronutrientes entre os diferentes grupos de agrominerais. A solubilidade e a disponibilidade de Cu, Ni e Zn dependem da solubilidade dos minerais que compõem os agrominerais.

Abstract: The objective of this work was to evaluate the solubility of the micronutrients copper, nickel, and zinc, chemically extracted from silicate agrominerals, as alternative sources of potassium for lettuce (Lactuca sativa) and rice (Oryza sativa) cultures, as well as their availability to the plants. The micronutrient contents of five agrominerals (alkaline ultramafic, biotite schist, volcanic breccia, phlogopite schist, and mining by-product from Chapada) were evaluated, after being extracted by the citric acid, hydrochloric acid, diethylenetriaminepentaacetic acid, 3051A, neutral ammonium citrate, and Mehlich-3 methods. The agrominerals, at the doses of 0 (control), 200, 400, and 600 kg ha-1 K, were mixed to soil where lettuce and rice were cultivated. The agrominerals presented a low solubility of Ni, Cu, and Zn, with lower contents in lettuce shoots and rice grains than the corresponding soluble standards in sulfate form. The availability of micronutrients to the plants increased with the use of agrominerals, in comparison with the control. Similarities were observed in micronutrient solubility and availability between the different groups of agrominerals. The solubility and availability of Cu, Ni, and Zn depend on the solubility of the minerals that compose the agrominerals.

https://doi.org/10.1590/s1678-3921.pab2020.v55.00807 1605 downloads

12.

Nitrogen use efficiency and forage production in intraspecific hybrids of Paspalum notatum Flüggé
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Graminho, Larissa A.

; Dall'Agnol, Miguel

; Pötter, Luciana

; Nabinger, Carlos

; Motta, Eder A.M. da

; Souza, Cleber H.L. de

; Krycki, Karine C.

; Weiler, Roberto L.

; Correa, Augusto F.

; Neto, Douglas

Chilean journal of agricultural research

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sep 2019, Volume 79 N. 3 Pages 447 - 455

Abstract: En | Text: En | PDF: En

ABSTRACT The rational use of N fertilization is essential to increase the recovery efficiency and crop productivity and decrease the cost of production. The objective of this study was to assess forage yield (TDM), tillers population density (TPD) and N use efficiency (NUE) in six Paspalum notatum Flüggé genotypes in response to N fertilization. The experimental design involved randomized blocks on a subdivided plot design. In 2014-2015 the TDM was higher for the C22 and B26 hybrids (P < 0.0001), which were similar to each other, with an average of 6173 kg DM ha-1 yr-1. In 2015-2016 the TDM of the genotypes ranging from 7053 to 13773 kg DM ha-1 yr-1, for pastures fertilized with 0 and 480 kg N ha-1 yr-1, respectively. An interaction was found between Genotype × N fertilization level (P = 0.0155) for TDM in 2016-2017. In the years 2015-2016 and 2016-2017 the C22 hybrid standed out as the genotype with the highest tiller production in response to N fertilization. In the year 2014-2015 NUE was higher (P = 0.0015) in the N fertilization levels N60, being of 15.5 kg DM kg-1 N. In the years 2015-2016 and 2016-2017 the NUE was higher at fertilization level N120 (P < 0.05), being of 21.1 and 31.5 kg DM kg-1 N, respectively. The C22 hybrid was distinct as the genotype with the highest DM yield and superior tillering characteristics. The N fertilization level of 120 kg N ha-1 yr-1 promoted greater NUE in all P. notatum genotypes

374 downloads

13.

High-resolution computed tomography findings of pulmonary tuberculosis in lung transplant recipients
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Giacomelli, Irai Luis

; Schuhmacher Neto, Roberto

; Nin, Carlos Schuller

; Cassano, Priscilla de Souza

; Pereira, Marisa

; Moreira, José da Silva

; Nascimento, Douglas Zaione

; Hochhegger, Bruno

Jornal Brasileiro de Pneumologia

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aug 2017, Volume 43 N. 4 Pages 270 - 273

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: As infecções respiratórias constituem a principal causa de morbidade e mortalidade em transplantados de órgãos sólidos. A incidência de tuberculose pulmonar é alta entre esses pacientes. Em exames de imagem, a tuberculose tem diferentes apresentações. Uma maior compreensão dessas apresentações poderia reduzir o impacto da doença ao facilitar o diagnóstico precoce. Portanto, buscamos descrever os padrões de tuberculose pulmonar na TCAR em transplantados de pulmão. Métodos: De dois hospitais no sul do Brasil, foram coletados os seguintes dados sobre transplantados de pulmão que desenvolveram tuberculose pulmonar: sexo; idade; sintomas; doença pulmonar que levou ao transplante; padrão na TCAR; distribuição dos achados; tempo entre transplante e tuberculose pulmonar; e taxa de mortalidade. Os achados na TCAR foram classificados como nódulos miliares; cavitação e nódulos centrolobulares com padrão de árvore em brotamento; atenuação em vidro fosco com consolidação; linfonodomegalia mediastinal; ou derrame pleural. Resultados: Foram avaliados 402 transplantados de pulmão, dos quais 19 desenvolveram tuberculose pulmonar após o transplante. Entre esses 19 pacientes, os padrões mais comuns na TCAR foram atenuação em vidro fosco com consolidação (em 42%); cavitação e nódulos centrolobulares com padrão de árvore em brotamento (em 31,5%); e linfonodomegalia mediastinal (em 15,7%). Entre os pacientes com cavitação e nódulos centrolobulares com padrão de árvore em brotamento, esses achados se distribuíam nos lobos superiores em 66,6%. Não se observou derrame pleural. Apesar do tratamento, a mortalidade em um ano foi de 47,3%. Conclusões: O padrão predominante na TCAR foi atenuação em vidro fosco com consolidação, seguido por cavitação e nódulos centrolobulares com padrão de árvore em brotamento. Esses achados são semelhantes aos relatados para pacientes imunocompetentes com tuberculose pulmonar e consideravelmente diferentes dos relatados para portadores de AIDS com a mesma doença.

ABSTRACT Objective: Respiratory infections constitute a major cause of morbidity and mortality in solid organ transplant recipients. The incidence of pulmonary tuberculosis is high among such patients. On imaging, tuberculosis has various presentations. Greater understanding of those presentations could reduce the impact of the disease by facilitating early diagnosis. Therefore, we attempted to describe the HRCT patterns of pulmonary tuberculosis in lung transplant recipients. Methods: From two hospitals in southern Brazil, we collected the following data on lung transplant recipients who developed pulmonary tuberculosis: gender; age; symptoms; the lung disease that led to transplantation; HRCT pattern; distribution of findings; time from transplantation to pulmonary tuberculosis; and mortality rate. The HRCT findings were classified as miliary nodules; cavitation and centrilobular nodules with a tree-in-bud pattern; ground-glass attenuation with consolidation; mediastinal lymph node enlargement; or pleural effusion. Results: We evaluated 402 lung transplant recipients, 19 of whom developed pulmonary tuberculosis after transplantation. Among those 19 patients, the most common HRCT patterns were ground-glass attenuation with consolidation (in 42%); cavitation and centrilobular nodules with a tree-in-bud pattern (in 31.5%); and mediastinal lymph node enlargement (in 15.7%). Among the patients with cavitation and centrilobular nodules with a tree-in-bud pattern, the distribution was within the upper lobes in 66.6%. No pleural effusion was observed. Despite treatment, one-year mortality was 47.3%. Conclusions: The predominant HRCT pattern was ground-glass attenuation with consolidation, followed by cavitation and centrilobular nodules with a tree-in-bud pattern. These findings are similar to those reported for immunocompetent patients with pulmonary tuberculosis and considerably different from those reported for AIDS patients with the same disease.

https://doi.org/10.1590/s1806-37562016000000306 27710 downloads

14.

Nitrogen loss by volatilization of nitrogen fertilizers applied to coffee orchard
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Dominghetti, Anderson William

; Guelfi, Douglas Ramos

; Guimarães, Rubens José

; Caputo, André Luiz Carvalho

; Spehar, Carlos Roberto

; Faquin, Valdemar

Ciência e Agrotecnologia

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apr 2016, Volume 40 N. 2 Pages 173 - 183

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A volatilização de amônia é uma das principais causas da redução da eficiência no uso de fertilizantes nitrogenados em lavouras cafeeiras. Neste trabalho, objetivou-se quantificar as perdas de nitrogênio por volatilização de fertilizantes nitrogenados aplicados em lavoura cafeeira. O experimento foi realizado em condições de campo, em um Latossolo Vermelho distrófico, cultivado com café, localizado no Setor de Cafeicultura/Departamento de Agricultura/UFLA, Lavras - MG. O delineamento experimental foi em blocos casualizados e os tratamentos foram: ureia; nitrato de amônio; ureia + 0,15% de Cu + 0,4% de B; ureia + polímeros; ureia + enxofre elementar (S0) + polímeros e; ureia + resina plástica; distribuídos em três parcelamentos com doses iguais de 150 kg ha-1. Foram quantificadas as perdas de nitrogênio por volatilização (N-NH3) e as variações no pH em água, da camada de 0-5 cm de solo, antes e depois dos parcelamentos das adubações nitrogenadas. Os fertilizantes nitrogenados reduziram os valores do pH do solo após as três adubações de manutenção. A perda de nitrogênio por volatilização dos fertilizantes nitrogenados (média das três adubações) foi: ureia + polímeros (35,8% do total do N aplicado) > ureia (31,2%) = ureia + S0 + polímeros (31,0%) > ureia + Cu + B (25,6%) > ureia + resina plástica (8,6%) = nitrato de amônio (1,0%).

ABSTRACT Ammonia volatilization (N-NH3) is one of the main pathways of Nitrogen loss reducing nitrogen use efficiency in coffee orchard. This work aimed at quantifying ammonia volatilization (N-NH3) losses from N-sources to be used in coffee plantations fertilization in Brazil. The experiment was conducted in the field on a dystrophic red latosol (Ferralsol in FAO's classification) at the Coffee Research Sector, University of Lavras, MG, Brazil. The experimental design was of complete randomized blocks with three repetitions of the following treatments: conventional urea, ammonium nitrate and urea + 0.15% Cu and 0.4% B, urea + anionic polymers, urea + elementary sulfur (S0) + polymers, and urea + plastic resin. These N sources were split into three doses of 150 kg ha-1 and band applied. The N-NH3 losses by volatilization and variations of pH (H2O) were measured, before and after N application. The N-sources contributed to reduce the soil pH, measured after the third nitrogen fertilization. The N-NH3 losses by volatilization (average from three applications) was as follows: urea + anionic polymers (35.8%) > conventional urea (31.2%) = urea + S0 + polymers (31.0%) > urea + 0.15% Cu + 0.4 % B (25.6%) > urea + plastic resin (8.6%) = ammonium nitrate (1.0%).

https://doi.org/10.1590/1413-70542016402029615 4206 downloads

15.

Ammonia volatilization from enhanced-efficiency urea on no-till maize in brazilian cerrado with improved soil fertility
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Cancellier, Eduardo Lopes

; Silva, Douglas Ramos Guelfi

; Faquin, Valdemar

; Gonçalves, Bruno de Almeida

; Cancellier, Leandro Lopes

; Spehar, Carlos Roberto

Ciência e Agrotecnologia

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apr 2016, Volume 40 N. 2 Pages 133 - 144

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A aplicação de ureia, frequentemente, gera grandes perdas de N por volatilização e o uso de revestimentos e inibidores de urease, podem reduzir essas perdas. Neste estudo, objetivou-se avaliar as perdas de nitrogênio pela ureia estabilizada e de liberação lenta ou controlada e sua absorção pelo milho cultivado em plantio direto, em solo de Cerrado, com fertilidade construída. Quatro fontes de N foram utilizadas: ureia convencional, ureia + N-(n-butyl)thiophosphoric triamide (NBPT), ureia + Cu + B e ureia revestida por enxofre e polímeros. Essas fontes de N foram aplicadas em superfície nas doses de 100, 150 e 200 kg ha-1. Não houve aplicação de N no controle. Avaliaram-se as perdas de N por volatilização, o acúmulo de N nos grãos e palhada e produção de grãos e de palhada. A ureia estabilizada e de liberação controlada foi eficiente em atrasar os picos de volatilização de amônia. Os inibidores de urease atrasaram os picos de volatilização em até dois dias, reduzindo a volatilização acumulada em até 18%, quando comparado à ureia comum. A ureia revestida por enxofre e polímeros resultou em uma redução de 37% na volatilização de amônia. O aumento da dose de N até 200 kg ha-1 resultou em aumento de 16% na produtividade e 37% no acúmulo de N em relação ao controle. Entretanto, a ureia estabilizada e de liberação controlada não aumentou o acúmulo de N ou a produtividade. Consequentemente, a eficiência no uso de N pelo milho não foi aumentada em relação ao use da ureia convencional.

ABSTRACT High nitrogen losses by ammonia volatilization are expected when urea is used as the source of N. The use of controlled-release urea and urease inhibitors are possible strategies to reduce such losses and increase nitrogen use efficiency. This study aimed to evaluate nitrogen losses by ammonia volatilization from stabilized, slow and controlled release urea and its absorption by maize grown under no-till in an improved Cerrado soil. Four N sources were used: conventional urea, urea + N-(n-butyl) thiophosphoric triamide (NBPT), urea + Cu and B and urea coated by sulfur + polymers. These N sources were surface applied along the rows using three N doses of 100, 150 and 200 kg ha-1. No N was added to the control. Data were collected regarding N losses by volatilization, the N contents accumulated in the stubble and grains, and the yields of the stubble and grains. Stabilized urea and slow release urea were efficient for postponing the ammonia volatilization peaks. The urease inhibitors postponed the peaks for up to two days, reducing the accumulated volatilization by 18% when compared with common urea. Polymer sulfur coated urea resulted in a 37% reduction in ammonia volatilization. Increasing the N application rate to 200 kg ha-1 resulted in 16% greater yields and 37% greater N accumulation in the plants relative to the control. However, the stabilized and slow-release urea did not improve the N accumulation or yield. Consequently, the nitrogen use efficiency of maize was not improved relative to the use of conventional urea.

https://doi.org/10.1590/1413-70542016402031115 3921 downloads

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