Resumo O texto discute os desafios para promoção da saúde de homens que fazem sexo com homens (HSHs) por meio de dados oriundos de uma roda de conversa, com pessoas de instituições que prestam serviços para HSHs na Região Metropolitana do Recife. Os resultados permitiram identificar desafios para o trabalho de promoção à saude, não só para HSHs, mas para pessoas sexo-dissidentes: dificuldades com o uso das categorias de identidade; estigmatização por prestar-lhes cuidado em saúde sexual; racismo estrutural; contexto de privação de liberdade; extrema pobreza; letramento. (HSHs conversa Recife saude sexodissidentes dissidentes sexo-dissidentes identidade prestarlhes prestar lhes sexual estrutural liberdade pobreza letramento

Abstract This work discusses the health promotion challenges of men who have sex with men (MSM) through the use of data from a conversation circle with people from institutions that provide services to MSM in the Metropolitan Region of Recife. The results allow for the identification of the following challenges for health promotion work, not only for MSM but also for sex dissidents: difficulties with the use of identity categories, stigmatization for providing them with sexual health care, structural racism, the deprivation of liberty, extreme poverty, and literacy. (MSM Recife dissidents categories care racism liberty poverty literacy

Resumo O texto discute os desafios para promoção da saúde de homens que fazem sexo com homens (HSHs) por meio de dados oriundos de uma roda de conversa, com pessoas de instituições que prestam serviços para HSHs na Região Metropolitana do Recife. Os resultados permitiram identificar desafios para o trabalho de promoção à saude, não só para HSHs, mas para pessoas sexo-dissidentes: dificuldades com o uso das categorias de identidade; estigmatização por prestar-lhes cuidado em saúde sexual; racismo estrutural; contexto de privação de liberdade; extrema pobreza; letramento.

Abstract This work discusses the health promotion challenges of men who have sex with men (MSM) through the use of data from a conversation circle with people from institutions that provide services to MSM in the Metropolitan Region of Recife. The results allow for the identification of the following challenges for health promotion work, not only for MSM but also for sex dissidents: difficulties with the use of identity categories, stigmatization for providing them with sexual health care, structural racism, the deprivation of liberty, extreme poverty, and literacy.

ABSTRACT The ideal ventral hernia surgical repair is still in discussion1. The defect closure with a mesh-based repair is the base of surgical repair, in open or minimally invasive techniques2. The open methods lead to a higher surgical site infections incidence, meanwhile, the laparoscopic IPOM (intraperitoneal onlay mesh) increases the risk of intestinal lesions, adhesions, and bowel obstruction, in addition to requiring double mesh and fixation products which increase its costs and could worsen the post-operative pain3-5. The eTEP (extended/enhanced view totally intraperitoneal) technique has also arisen as a good option for this hernia repair. To avoid the disadvantages found in classic open and laparoscopic techniques, the MILOS (Endoscopically Assisted Mini or Less Open Sublay Repair) concept, created by W. Reinpold et al. in 2009, 3 years after eTEP conceptualization, allows the usage of bigger meshes through a small skin incision and laparoscopic retro-rectus space dissection, as the 2016 modification, avoiding an intraperitoneal mesh placement6,7. This new technique has been called E-MILOS (Endoscopic Mini or Less Open Sublay Repair)8. The aim of this paper is to report the E-MILOS techniques primary experience Brazil, in Santa Casa de Misericórdia de São Paulo. discussion1 discussion meshbased based techniques2 incidence meanwhile lesions adhesions obstruction postoperative post operative pain35. pain35 pain pain3 5. 5 pain3-5 extended/enhanced extendedenhanced extended enhanced Endoscopically Repair concept W al 2009 conceptualization retrorectus retro rectus dissection 201 modification placement67 placement placement6 7 placement6,7 EMILOS E Endoscopic Repair8. Repair8 8. 8 Repair)8 Brazil Paulo pain3- 200 20 placement6, 2

RESUMO O tratamento cirúrgico ideal para correção das hérnias ventrais ainda é motivo de grande discussão1. O fechamento do defeito associado a utilização de telas para reforço da parede abdominal são passos fundamentais da terapia cirúrgica, podendo ser realizados tanto pela via aberta quanto pelas técnicas minimamente invasivas2. A via aberta apresenta maiores taxas de infecção de sítio cirúrgico, enquanto o reparo laparoscópico IPOM (intraperitoneal onlay mesh) acarreta um risco aumentado de lesões intestinais, aderências e obstruções intestinais, além de requerer uso de telas de dupla face e dispositivos de fixação que encarecem o procedimento e não raro aumentam a dor no pós-operatório3-5. A técnica eTEP (extended/enhanced view totally extraperitoneal), tem ganhado importância, mostrando-se uma boa opção para a correção das hérnias ventrais também2. A fim de se evitar as desvantagens das técnicas abertas e laparoscópicas “clássicas” o conceito MILOS (Endoscopically Assisted Mini or Less Open Sublay Repair), desenvolvido por W. Reinpold et al. em 2009, 3 anos antes do advento do eTEP, possibilita ao cirurgião o uso de telas de grandes dimensões no plano retromuscular através de uma pequena incisão na pele e dissecção laparoscópica deste espaço, conforme modificação realizada em 2016, evitando a colocação de uma tela no espaço intraperitoneal6-7. Esta nova técnica passou a se chamar EMILOS (Endoscopic Mini or Less Open Sublay Repair)8 Este artigo tem como objetivo relatar nossa experiência inicial no emprego da técnica E-MILOS no Brasil, na Santa Casa de Misericórdia de São Paulo. discussão1 discussão cirúrgica invasivas2 invasivas intraperitoneal mesh intestinais pósoperatório35. pósoperatório35 pósoperatório pós operatório3 5. 5 operatório pós-operatório3-5 extended/enhanced extendedenhanced extended enhanced extraperitoneal, extraperitoneal , extraperitoneal) importância mostrandose mostrando também2 também clássicas “clássicas Endoscopically Repair, Repair Repair) W al 2009 2016 intraperitoneal67. intraperitoneal67 intraperitoneal6 7. 7 intraperitoneal6-7 Endoscopic Repair8 8 E Brasil Paulo pósoperatório3 pós-operatório3- 200 201 intraperitoneal6- pós-operatório3 20 pós-operatório 2

ABSTRACT Objective To identify and analyze the quality of scientific evidence from clinical efficacy studies present in the package inserts of coagulation factors, used in the treatment of hemophilia A and B. Methods Documentary study developed in two stages. The first stage consisted of identifying the medicine packages inserts electronically registered in the Brazilian Health Regulatory Agency, and analyzing the availability of the bibliographic references cited therein. This analysis was conducted in the PubMed, SciELO, Google Scholar, and Web of Science databases. The second step was the analysis of the methodological quality of the efficacy studies. Two trained researchers used the Cochrane Collaboration Risk of Bias version 5.1.0 tools for methodological quality analysis, and Review Manager 5.4 software to generate the risk of bias graph. Results Of the 17 medicines listed, 7 had referenced package inserts. Of these, 10 studies were eligible for analysis of methodological quality. More than half of the analyzed studies did not control for selection, performance, and detection bias. A total of 100% controlled attrition and reporting biases, and 50% had a high risk of conflict of interest. Conclusion The biases present are significant and may have influenced the overestimation of the effects of the outcomes of each of the studies.

Abstract INTRODUCTION: Visceral leishmaniasis (VL) and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) co-infection has been a research topic of interest worldwide. In Brazil, it has been observed that there is a relative underreporting and failure in the understanding and management of this important association. The aim of this study was to analyze epidemiological and clinical aspects of patients with VL with and without HIV/AIDS. METHODS: We conducted an observational and analytical study of patients with VL followed in a Reference Service in the State of Maranhão, Brazil from 2007-2013. RESULTS: In total 126 patients were enrolled, of which 61 (48.4%) were co-infected with HIV/AIDS. There were more males among those with HIV/AIDS (85.2%, P>0.05) or with VL only (81.5%, P>0.05). These findings significantly differed based on age group (P<0.003); the majority of patients were aged 31-40 years (41.0%) and 21-30 years (32.3%) among those with and without HIV/AIDS co-infection, respectively. The incidence of diarrhea and splenomegaly significantly differed between the two groups (P=0.0014 and P=0.019, respectively). The myelogram parasitic examination was used most frequently among those with HIV/AIDS (91.8%), followed by those with VL only (69.2%). VL recurrences and mortality were significantly higher in the HIV/AIDS co-infected patients (P<0.0001 and P=0.012, respectively). CONCLUSIONS: Patients with VL with or without HIV/AIDS co-infection were mostly adult men. Diarrhea was more frequent in HIV/AIDS co-infected patients, whereas splenomegaly was more common in patients with VL only. In the group of HIV/AIDS co-infected patients, there was a higher rate of VL recurrence and mortality.

The common bean cultivar "BRSMG Realce", recommended for the state of Minas Gerais, has high yield potential and resistance to powdery mildew, bacterial wilt and to anthracnose pathotypes 65, 73, 77, 81, 91, 475 and 479. The plants and pods are high, resulting in lower loss during mechanical harvest.

The bean cultivar BRSMG União as a new option of a bean cultivar with jalo grains for the state of Minas Gerais. The cultivar BRSMG União had an average grain yield of 9.8% above the mean of the controls (Jalo EEP 558 and BRS Radiante) and was resistant to powdery-mildew.

The cultivar BRSMG Madrepérola, recommended for cultivation in Minas Gerais, has the feature of maintaining a light grain color for a longer period than other Carioca grain cultivars. The yield potential is high and the resistance level good to the major anthracnose races in the region.