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au:De Souza, Diogo Benchimol

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Metabolic and ultrastructural renal changes in adult Wistar rats fed by a cafeteria diet
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Santos, Priscila Fernandes dos

; Souza, Diogo Benchimol de

; Torres, Eduardo José Lopes

; Costa, Waldemar Silva

; Sampaio, Francisco José Barcellos

; Gregorio, Bianca Martins

Acta Cirúrgica Brasileira

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2024, Volume 39 elocation e392224

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To evaluate, by quantitative and qualitative methods, the glomerular ultrastructure in Wistar rats fed a cafeteria diet. Methods: Male Wistar rats were divided into two groups at 21 days of age: control (C, n = 10) and cafeteria diet (CAF, n = 8). The animals were followed up until 5 months of age, followed by euthanasia. The blood, kidneys, and fat deposits––epididymal, retroperitoneal, and subcutaneous––were extracted and analyzed. Data were analyzed by Student’s t test, and p < 0.05 was considered statistically significant. Results: The cafeteria diet promoted glucose intolerance, hyperglycemia (p < 0.0001), and deposition of retroperitoneal fat (p < 0.005). Scanning electron microscopy revealed that the length of the foot process was similar in both groups. The quantitative analyses by transmission electron microscopy revealed that the cafeteria diet reduced the thickness of the glomerular basement membrane (p < 0.05). Conclusions: The intake of lipids and simple carbohydrates were found to be associated with alteration in the glomerular ultrastructure. However, more studies are needed to evaluate not only the effects of high-protein and high-fat diets on components of the glomerular filtration barrier, but also renal physiology.

https://doi.org/10.1590/acb392224

Diretriz Brasileira de Dispositivos Cardíacos Eletrônicos Implantáveis – 2023 202 20 2
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Teixeira, Ricardo Alkmim

; Fagundes, Alexsandro Alves

; Baggio Junior, José Mário

; Oliveira, Júlio César de

; Medeiros, Paulo de Tarso Jorge

; Valdigem, Bruno Pereira

; Teno, Luiz Antônio Castilho

; Silva, Rodrigo Tavares

; Melo, Celso Salgado de

; Elias Neto, Jorge

; Moraes Júnior, Antonio Vitor

; Pedrosa, Anisio Alexandre Andrade

; Porto, Fernando Mello

; Brito Júnior, Hélio Lima de

; Souza, Thiago Gonçalves Schroder e

; Mateos, José Carlos Pachón

; Moraes, Luis Gustavo Belo de

; Forno, Alexander Romeno Janner Dal

; D’Avila, Andre Luiz Buchele

; Cavaco, Diogo Alberto de Magalhães

; Kuniyoshi, Ricardo Ryoshim

; Pimentel, Mauricio

; Camanho, Luiz Eduardo Montenegro

; Saad, Eduardo Benchimol

; Zimerman, Leandro Ioschpe

; Oliveira, Eduardo Bartholomay

; Scanavacca, Mauricio Ibrahim

; Martinelli Filho, Martino

; Lima, Carlos Eduardo Batista de

; Peixoto, Giselle de Lima

; Darrieux, Francisco Carlos da Costa Duarte, Jussara de Oliveira Pinheiro Galvão Filho, Silas dos Santos Costa, Eduardo Rodrigues Bento Mateo, Enrique Indalécio Pachón Melo, Sissy Lara De Rodrigues, Thiago da Rocha Rocha, Eduardo Arrais Hachul, Denise Tessariol Lorga Filho, Adalberto Menezes Nishioka, Silvana Angelina D’Orio Gadelha, Eduardo Barreto Costa, Roberto Andrade, Veridiana Silva de Torres, Gustavo Gomes Oliveira Neto, Nestor Rodrigues de Lucchese, Fernando Antonio Murad, Henrique Wanderley Neto, José Brofman, Paulo Roberto Slud Almeida, Rui M. S. Leal, João Carlos Ferreira

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 1 elocation e20220892

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.36660/abc.20220892

Effects of chronic restraint stress in the prostate of prepubertal and adult rats
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Procópio, Isabella Mendes

; Ribeiro, Carina Teixeira

; Marchon, Roger Gaspar

; Costa, Waldemar Silva

; Buys-Gonçalves, Gabriela Faria

; Sampaio, Francisco José Barcellos

; Pereira-Sampaio, Marco Aurélio

; Souza, Diogo Benchimol de

Acta Cirúrgica Brasileira

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2023, Volume 38 elocation e387123

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To investigate the effects of chronic stress in the prostate of prepubertal and adult rats. Methods: Thirty-two male rats were assigned into four groups depending on the type of treatment (control or stressed) and the age at which stress was initiated (prepubertal or adult). Restraint stress stimuli were applied for six weeks. Stressed prepubertal and adult rats evaluated immediately after the last stress stimuli were named SP and SA groups, respectively. Age-matched rats were used as control groups (CP and CA). At the end of the experiment, the rats were euthanized, and prostate morphological parameters were evaluated and statistically compared. Results: Application of stress stimuli to the SP group resulted in reduced body weight, but no prostate morphological modification was noted. The SA group showed reduced testosterone level and prostatic epithelium surface density, in comparison to CA group. Further, the prostatic lumen surface density was increased in adult stressed animals, in comparison to adult controls. Conclusions: The stress stimuli promoted changes in hormonal and morphological parameters in the prostate of adult stressed rats. Prepubertal stressed animals did not presented modifications of prostate morphology.

https://doi.org/10.1590/acb387123

Quercetin as a nephroprotector after warm ischemia: histomorphometric evaluation in a rodent model
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Gonçalves, Gabriela F. Buys

; Silva, Maria Eduarda M. Sampaio, Francisco J. B. Pereira-Sampaio, Marco A. Souza, Diogo Benchimol de

International braz j urol

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aug 2021, Volume 47 N. 4 Pages 796 - 802

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To quantitatively evaluate the possible long-term protective effects of quercetin during renal warm ischemia. Materials and Methods: Male rats were allocated into 4 groups: sham (S), sham quercetin (SQ), ischemia (I), and ischemia quercetin (IQ). Groups SQ and IQ received quercetin (50mg/kg) before and after surgery. Groups I and IQ had their left renal vessels clamped for 60 minutes. All animals were euthanized four weeks after the procedure, and serum urea and creatinine levels were measured. Renal weight and volume, cortex-non-cortex area ratio (C-NC), cortical volume (CV), glomerular volumetric density (Vv[glom]), volume-weighted glomerular volume (VWGV) and number of glomeruli per kidney (N[glom]) were evaluated by stereological methods. Results were considered statistically significant when p <0.05. Results: Serum urea levels in group I increased by 10.4% in relation to group S, but no differences were observed among the other groups. The C-NC of group I was lower than those of all other groups, and group IQ had similar results to sham groups. The Vv[glom] and N[glom] of group I were lower than those of group S (33.7% and 28.3%, respectively) and group IQ had no significant difference compared to the S group. Conclusions: Quercetin was effective as a nephroprotective agent in preventing the glomerular loss observed when the kidney was subjected to warm ischemia. This suggests that this flavonoid may be used preventively in kidney surgery, when warm ischemia is necessary, such as partial nephrectomy.

https://doi.org/10.1590/s1677-5538.ibju.2020.0358 95 downloads

Effects of nandrolone decanoate on femur morphology. Experimental study
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Souza, Diogo Benchimol de

; Brasil, Flavia Bittencourt

; Marchon, Roger Gaspar

; Félix-Patrício, Bruno

Acta Cirúrgica Brasileira

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2021, Volume 36 N. 5 elocation e360507

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose To evaluate the immediate and late effects of nandrolone on femur morphology of rats. Methods Twenty-eight animals with 20 weeks of age were divided into four groups: C28, control animals that were euthanized eight weeks after the experiment started; C40, control animals euthanized 20 weeks after the experiment started; T28, treated animals receiving nandrolone during eight weeks and euthanized immediately after the treatment period; and T40, animals treated during eight weeks and euthanized 12 weeks after the end of the treatment. Treated animals received nandrolone decanoate during eight weeks and control groups received peanut oil by intramuscular injection. After euthanasia, femurs were removed, dissected, weighted and measured by digital pachymeter. Results The T40 group presented an increase on distal epiphysis diameter when compared to C40 group. There was no difference between treated and control groups in relation to body and femur absolute weight, relative weight and length of femur. There was also no difference in relation to diameter of proximal epiphysis and diameter of diaphysis among the groups. Conclusions Nandrolone decanoate does not produce significant effect on femur, exception on its distal extremity at late period. The effects of such drug may depend on the time after administration.

https://doi.org/10.1590/acb360507 126 downloads

Histomorphometric comparison of the corpus cavernosum of rats submitted to euthanasia with ketamine and xylazine or isoflurane
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Procópio, Isabella Mendes

; Pereira-Sampaio, Marco Aurélio

; Costa, Waldemar Silva

; Sampaio, Francisco José Barcellos

; Souza, Diogo Benchimol de

Acta Cirúrgica Brasileira

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2021, Volume 36 N. 11 elocation e361103

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To compare the penile histoarchitecture of rats euthanized with isoflurane or with ketamine and xylazine. Methods: Fourteen male rats were divided into two groups: ISO, with animals euthanized with isoflurane; and K+X, with animals euthanized with ketamine (150 mg/kg) associated with xylazine (15 mg/kg). Immediately after the death, the penises were dissected, fixed in a 4% buffered formalin solution, and processed for histomorphometric analysis. The surface densities (Sv) of the corpus cavernosum structures (connective tissue, smooth muscle, sinusoidal space, and elastic fibers) were evaluated using Image J software. The distribution of collagen types I and III was qualitatively assessed. Statistical analyses were performed using the Student’s t test for data comparison, considering it statistically significant when p < 0.05. Results: Regarding the Sv of connective tissue, smooth muscle and sinusoidal space, there were no differences between animals in both groups. On the other hand, the animals euthanized with the association of ketamine and xylazine showed the Sv of elastic fibers 24.8% higher in relation to animals euthanized with isoflurane. Conclusions: The euthanasia method affected one of the morphological parameters of the rat penises. The choice of euthanasia method must be standardized to reduce bias and to obtain reliable and reproducible results.

https://doi.org/10.1590/acb361103 1 downloads

Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study
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Silva, Marcello Henrique Araújo da

; Estrada, João Henrique Duque

; Gregório, Bianca Martins

; Sampaio, Francisco José Barcellos

; Souza, Diogo Benchimol de

Acta Cirúrgica Brasileira

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2021, Volume 36 N. 7 elocation e360703

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To investigate whether renal modifications occur following treatment with dutasteride or finasteride. Methods: Twenty-four male rats were divided into three groups: control (that received distilled water), dutasteride (0.5 mg/kg/day), and finasteride (5 mg/kg/day) groups. All administrations were given by gavage for 40 consecutive days. After inducing euthanasia, blood was collected for urea and creatinine analyses, and both the kidneys were collected for stereological analyses of kidney morphology. Results: Serum urea and creatinine levels were increased in both the finasteride and the dutasteride groups compared with those in the control group. In addition, kidney weight, kidney volume, cortical volume, glomerular volumetric density, and mean glomerular volume were reduced in both treatment groups. Finally, the number of glomeruli per kidney was reduced by 26.8% in the finasteride group and by 51.6% in the dutasteride group compared with that in the control group. Conclusions: The 5-ARIs finasteride and dutasteride promoted morphological and functional damages in rat kidneys. In addition, rats in the dutasteride group showed more severe renal modifications than those in the finasteride group.

https://doi.org/10.1590/acb360703 168 downloads

Editorial Comment: Improvement of fertility parameters with Tribulus Terrestris and Anacyclus Pyrethrum treatment in male rats
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Souza, Diogo Benchimol de

; Buys-Gonçalves, Gabriela Faria

International braz j urol

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sep 2019, Volume 45 N. 5 Pages 1055 - 1056

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/s1677-5538.ibju.2018.0843.1 356 downloads

The relationship between renal warm ischemia time and glomerular loss. An experimental study in a pig model
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Damasceno-Ferreira, José Aurelino Bechara, Gustavo Ruschi Costa, Waldemar Silva Pereira-Sampaio, Marco Aurélio Sampaio, Francisco José Barcellos Souza, Diogo Benchimol De

Acta Cirúrgica Brasileira

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may 2017, Volume 32 N. 5 Pages 334 - 341

Abstract: En | Text: En | PDF: En

Abstract Purpose: To investigate the glomerular number after different warm ischemia times. Methods: Thirty two pigs were assigned into four groups. Three groups (G10, G20, and G30) were treated with 10, 20, and 30 minutes of left renal warm ischemia. The sham group underwent the same surgery without renal ischemia. The animals were euthanized after 3 weeks, and the kidneys were collected. Right kidneys were used as controls. The kidney weight, volume, cortical-medullar ratio, glomerular volumetric density, volume-weighted mean glomerular volume, and the total number of glomeruli per kidney were obtained. Serum creatinine levels were assessed pre and postoperatively. Results: Serum creatinine levels did not differ among the groups. All parameters were similar for the sham, G10, and G20 groups upon comparison of the right and left organs. The G30 group pigs' left kidneys had lower weight, volume, and cortical-medullar ratio and 24.6% less glomeruli compared to the right kidney. A negative correlation was found between warm ischemia time and glomerular number. Conclusions: About one quarter of glomeruli was lost after 30 minutes of renal warm ischemia. No glomeruli loss was detected before 20 minutes of warm ischemia. However, progressive glomerular loss was associated with increasing warm ischemia time.

https://doi.org/10.1590/s0102-865020170050000002 1070 downloads

10.

Glomerular loss after arteriovenous and arterial clamping for renal warm ischemia in a swine model
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Bechara, Gustavo Ruschi Damasceno-Ferreira, José Aurelino Abreu, Leonardo Albuquerque dos Santos Costa, Waldemar Silva Sampaio, Francisco José Barcellos Pereira-Sampaio, Marco Aurélio Souza, Diogo Benchimol De

Acta Cirúrgica Brasileira

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nov 2016, Volume 31 N. 11 Pages 753 - 758

Abstract: En | Text: En | PDF: En

ABSTRACT PURPOSE: To evaluate the glomerular loss after arteriovenous or arterial warm ischemia in a swine model. METHODS: Twenty four pigs were divided into Group Sham (submitted to all surgical steps except the renal ischemia), Group AV (submitted to 30 minutes of warm ischemia by arteriovenous clamping of left kidney vessels), and Group A (submitted to 30 minutes of ischemia by arterial clamping). Right kidneys were used as controls. Weigh, volume, cortical volume, glomerular volumetric density (Vv[Glom]), volume-weighted glomerular volume (VWGV), and the total number of glomeruli were measured for each organ. RESULTS: Group AV showed a 24.5% reduction in its left kidney Vv[Glom] and a 25.4% reduction in the VWGV, when compared to the right kidney. Reductions were also observed when compared to kidneys of sham group. There was a reduction of 19.2% in the total number of glomeruli in AV kidneys. No difference was observed in any parameters analyzed on the left kidneys from group A. CONCLUSIONS: Renal warm ischemia of 30 minutes by arterial clamping did not caused significant glomerular damage, but arteriovenous clamping caused significant glomerular loss in a swine model. Clamping only the renal artery should be considered to minimize renal injury after partial nephrectomies.

https://doi.org/10.1590/s0102-865020160110000008 946 downloads

11.

Nutritional supplementation with arginine protects radiation-induced effects. An experimental study
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Pinto, Flavia Cristina Morone Campos-Silva, Pamella Souza, Diogo Benchimol de Costa, Waldemar Silva Sampaio, Francisco José Barcellos

Acta Cirúrgica Brasileira

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oct 2016, Volume 31 N. 10 Pages 650 - 654

Abstract: En | Text: En | PDF: En

ABSTRACT PURPOSE: To investigate the protective effect of L-arginine on the prostate (nonneoplasic) of rats with radiation-induced injury. METHODS: Twenty-nine Wistar rats, male adult, allocated into three groups: Control group (C) was not exposed to irradiation (n=10); Radiated group (R) had undergone pelvic irradiation (n=10); Supplemented and radiated group (R+S) had undergone pelvic irradiation plus L-arginine supplementation (n=9). The animals were observed for signs of toxicity. After euthanization, the prostate was dissected under magnification and stained by hematoxylin and eosin to study acinar structures and stained with Picrosirius red for collagen analysis. RESULTS: After radiation exposure, all animals presented diarrhea, but supplementation with L-arginine reduced this effect. The weight gain in the R+S group was significantly higher than in the C and R groups. In the R+S group the collagen density and the prostate acinar area was similar to the R and C groups. Epithelial height was significantly reduced in group R compared with group C (p<0.0001). When comparing the group R+S with R, a statistical difference was observed to be present (p<0.0001). CONCLUSIONS: Pelvic radiation promotes systemic effects and some structural modifications in the ventral prostate of rats. These modifications can be prevented by oral supplementation with L-arginine.

https://doi.org/10.1590/S0102-865020160100000002 1349 downloads

12.

Laparoscopic correction of experimentally induced diaphragmatic rupture in dogs
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Souza, Diogo Benchimol de Mariano, Carlos Magno Anselmo Andrade Jr., Paulo Sérgio Cruz de Coelho, Gabriela Correa Abílio, Edmundo Jorge

Acta Cirúrgica Brasileira

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aug 2015, Volume 30 N. 8 Pages 537 - 541

Abstract: En | Text: En | PDF: En

PURPOSE:To describe the dog as a model for studying laparoscopic correction of experimental diaphragmatic ruptures.METHODS: Five male dogs were used in this study. Under laparoscopic approach, a defect of 7cm was created on the left ventral insertion of the diaphragm. Fourteen days after this procedure, the abdomen was explored using laparoscopic access and the diaphragmatic defect was corrected with intracorporeal suture. The dislocated organs, surgical time, and suturing time were recorded. Analgesia and clinical condition were monitored during the postoperative period.RESULTS:All animals recovered well from the diaphragmatic rupture creation. After 14 days, abdominal organs (liver, spleen, omentum and/or intestine) were found inside the thoracic cavity in all animals. It was possible to reposition the organs and suture the defect by laparoscopic access in three animals. These animals showed excellent postoperative recovery. It was not possible to reposition the liver safely when it was friable.CONCLUSIONS:Laparoscopic creation of diaphragmatic rupture in dogs is feasible. Dogs are a good model for training and studying the correction of experimentally created diaphragmatic rupture by the laparoscopic approach. A friable liver is a complicating factor that should be taken into account. Animals submitted to laparoscopic correction showed excellent postoperative recovery.

https://doi.org/10.1590/S0102-865020150080000004 1827 downloads

13.

Morphometric study of the corpus cavernosum after anabolic androgenic steroid administration in pubertal and adult rats
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Sena, Alessandro de Sousa Mendes de Vargas, Rafael Areas Souza, Diogo Benchimol De Costa, Waldemar Silva Sampaio, Francisco José

Acta Cirúrgica Brasileira

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jul 2015, Volume 30 N. 7 Pages 478 - 483

Abstract: En | Text: En | PDF: En

PURPOSE: To evaluate the penile morphological modifications of pubertal and adult rats chronically treated with supra-physiological doses of anabolic androgenic steroids. METHODS: Forty-eight male Wistar rats were distributed into four groups: two control groups, 105- and 65-day-old (C105 and C65, respectively) injected with peanut oil (vehicle); and two treated groups, 105- and 65-day-old (T105 and T65, respectively) injected with nandrolone decanoate at a dose of 10 mg Kg-1 of body weight. The rats were injected once a week for eight weeks. The rats were then killed and their penises were processed for histomorphometric analyses. The mean of each parameter was statistically compared. RESULTS: A corpus cavernosum reduction of 12.5% and 10.9% was observed in the T105 and T65 groups, respectively, when compared with their respective control groups. The cavernosum smooth muscle surface density diminished by 5.6% and 12.9% in the T65 and T105 groups, respectively, when compared with their controls. In contrast, the sinusoidal space increased by 17% in the T105 group and decreased by 9.6% in the T65 group. CONCLUSION: The use of supra-physiological doses of AAS promotes structural changes in the rat penis, by altering the proportions of corpus cavernosum tissues, in both pubertal and adult treated animals.

https://doi.org/10.1590/S0102-865020150070000005 5042 downloads

14.

Experimental infection with the Toxoplasma gondii ME-49 strain in the Brazilian BR-1 mini pig is a suitable animal model for human toxoplasmosis
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Miranda, Farlen José Bebber Souza, Diogo Benchimol de Frazão-Teixeira, Edwards Oliveira, Fábio Conceição de Melo, João Cardoso de Mariano, Carlos Magno Anselmo Albernaz, Antonio Peixoto Carvalho, Eulógio Carlos Queiróz de Oliveira, Francisco Carlos Rodrigues de Souza, Wanderley de DaMatta, Renato Augusto

Memórias do Instituto Oswaldo Cruz

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feb 2015, Volume 110 N. 1 Pages 95 - 100

Abstract: En | Text: En | PDF: En

Toxoplasma gondii causes toxoplasmosis, a worldwide disease. Experimentation with pigs is necessary for the development of new therapeutic approaches to human diseases. BR-1 mini pigs were intramuscularly infected with T. gondii with tachyzoites (RH strain) or orally infected with cysts (ME-49 strain). Haematology and serum biochemistry were analysed and buffy coat cells were inoculated in mice to determine tachyzoite circulation. No alterations were observed in erythrocyte and platelet values; however, band neutrophils increased seven days after infection with ME-49. Serology of the mice inoculated with pig blood leucocytes revealed circulating ME-49 or RH strain tachyzoites in the pigs' peripheral blood at two and seven or nine days post-infection. The tachyzoites were also directly observed in blood smears from the infected pigs outside and inside leucocytes for longer periods. Alanine-aminotransferase was high at days 21 and 32 in the RH infected pigs. After 90 days, the pigs were euthanised and their tissue samples were processed and inoculated into mice. The mice serology revealed the presence of parasites in the hearts, ileums and mesenteric lymph nodes of the pigs. Additionally, cysts in the mice were only observed after pig heart tissue inoculation. The infected pigs presented similar human outcomes with relatively low pathogenicity and the BR-1 mini pig model infected with ME-49 is suitable to monitor experimental toxoplasmosis.

https://doi.org/10.1590/0074-02760140318 2624 downloads

15.

SCIENTIFIC LEADERS FOR THE FUTURE: PRIMARY AND SECONDARY EDUCATION
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Nascimento, Fernanda Amorim de Morais Gregório, Bianca Martins Souza, Diogo Benchimol de Sampaio, Francisco José Barcellos Ferreira, Lydia Masako

Revista do Colégio Brasileiro de Cirurgiões

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2015, Volume 42 Suppl. 1 Pages 40 - 43

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Objetivo: Apresentar um projeto piloto de inserção do ensino médio em programas de pós-graduação (PPG) e discutir os mecanismos para a formação de líderes em ciência. Métodos: Realizou-se um estudo de revisão e apresentação de piloto. A busca bibliográfica ocorreu nos sites da CAPES, MEC, Scielo e biblioteca de livros virtuais, de janeiro/2014 a fevereiro/2015. O piloto ocorre nos PPG-Medicina III em Cirurgia Translacional/UNIFESP e Fisiopatologia e Ciências Cirúrgicas/UERJ. Os alunos de iniciação científica júnior (ICj) são oriundos de escola pública e desenvolvem atividades científicas: participação em reuniões científicas, graduação e inserção nos projetos de pesquisa. A avaliação ocorrerá ao final de um ano, com redações dos resultados, relatórios e participações em eventos científicos. Resultados: No Brasil, um dos principais desafios da educação é a alta média de anos de estudo. O PNPG (2011-2020) apresenta a inserção da educação básica em todos os PPG. Na Fisiopatologia e Ciências Cirúrgicas/UERJ há atualmente 11 alunos do ensino médio, que já acompanharam as reuniões científicas e preparam-se para a inserção em projetos de pesquisa. Houve 30% de desistência, devido à alta carga horária escolar. Esse resultado e a experiência vivenciada permite criar alternativas futuras para aprimorar o projeto de inserção. Conclusão: A liderança em ciências é formada a partir de uma complexa relação entre educação básica e investimentos na pesquisa. Cursos de PPG-Medicina III seguem na vanguarda com iniciativas focadas no desenvolvimento científico e tecnológico. Assim, projetos envolvendo alunos da educação básica representam modelo e ambiente promotor de líderes.

Objective: To present a high school insertion pilot project in post graduate programs (PPG) and discuss the mechanisms for the formation of leaders in science. Methods: This study presents a review and pilot project. Bibliographic search occurred in sites of CAPES, MEC, SciELO and library of virtual books from January/ 2014 to February/2015. The pilot is in PPG-Medicine III Translational Surgery/UNIFESP and Pathophysiology and Surgical Sciences / UERJ. The junior undergraduate students (ICj) came from public school and develop scientific activities: scientific meetings, graduation and inclusion in research projects. The evaluation will occur at the end of one year, with the results essays, reports and participation in scientific events. Results: In Brazil, one of the main challenges of education is the high average years of study. The PNPG (2011-2020) shows the insertion of basic education in all PPG. In the Pathophysiology and Surgical Sciences/UERJ there are currently 11 high school students who have followed the scientific meetings and are being prepared for the inclusion in research projects. There was 30% of absence, owing to the high school hours. This result and the experience allow creating future alternatives to enhance the integration project. Conclusion: The leadership in science is formed from a complex relationship between basic education and investment in research. PPG-Medicine III courses follow the vanguard with initiatives focused on scientific and technological development. Thus, projects involving basic education students represent promoter model and environment leaders.

https://doi.org/10.1590/0100-69912015S01015 1519 downloads

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