In the context of the Community Programme in the field of Health, the European Commission financed a series of initiatives to support the development and use of indicators for planning health services for Rare Diseases (RDs). The European Project for Rare Disease National Plans Development (EUROPLAN) elaborated a set of 59 process and outcome indicators, for monitoring the implementation and for evaluating the impact of the National Plans on RDs. Due to the high number and difficulty in handling the indicators, the subsequent Joint Action "Working for RDs" planned to derive a selection of 21 core indicators that were adopted by the European Union Committee of Experts on RDs in June 2013. The descriptive study carried out in the framework of the Joint Action to select the key indicators to orient policies for RDs shows that core indicators represent an excellent opportunity to share knowledge and comparability among Member States.
Cancer incidence was investigated in an area which has been affected by the illegal practices of dumping hazardous waste and setting fire to mismanaged waste. For the 35 municipalities of this area that are served by a Cancer Registry, municipal standardized incidence ratios (SIR) and hierarchical Bayesian estimators (BIR) were computed. Moreover, municipal spatial clustering and a Poisson regression by municipality index of waste-related exposure were performed for 10 cancer types. Increased municipality SIRs were found for some cancer types. The BIRs confirmed the increases for liver cancer in two municipalities. Statistically significant clusters were detected for liver, lung, leukaemia and soft tissue sarcomas. In the regression analysis, testis cancer showed significant trend with the index of waste-related exposure (RR = 1.18).
È stata investigata l'incidenza oncologica in un'area interessata da pratiche illegali di smaltimento e di combustione incontrollata di rifiuti. Per i 35 comuni di quest'area serviti da un Registro Tumori sono stati calcolati i rapporti standardizzati di incidenza (standardized incidence ratios, SIR) e gli stimatori bayesiani (BIR). Per 10 sedi tumorali sono state eseguite, inoltre, analisi di cluster spaziali e di regressione con un indice municipale di esposizione a rifiuti. SIR in eccesso sono stati osservati per diverse sedi tumorali; i BIR hanno confermato gli eccessi di tumore epatico in due comuni. I tumori epatici e polmonari, le leucemie e i sarcomi dei tessuti molli hanno mostrato cluster significativi. Nell'analisi di regressione il tumore del testicolo ha mostrato un trend in eccesso significativo (RR = 1,18).