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Toads of the Rhinella genus have a pair of paratoid glands that store biological secretions of high toxicity and varied chemical composition, rich in biologically active compounds. The present work aimed to carry out the investigation of the metabolomic profile and evaluation of the biological potential of the secretion paratoid glands (PGS) from Rhinella granulosa. The paratoid secretion was collected in the Piauí state (Brazil), extracted with methanol and the extract was analyzed by ultra-performance liquid chromatography with quadrupole time-of-flight mass spectrometry. Fifty chemical constituents were identified. The extract showed cytotoxicity against tumor cell lines of the central nervous system (half maximal inhibitory concentration (IC50) = 1.9 µg mL-1) and prostate (IC50 = 1.6 µg mL-1), unsatisfactory antimicrobial potential (minimal inhibitory concentration (MIC) > 312 µg mL-1) and inhibited the enzyme acetylcholinesterase (IC50 = 5.119 mg mL-1). The results presented relevant information about the PGS and contributed to the understanding of the metabolomic and biological potential of R. granulosa.

https://doi.org/10.21577/0103-5053.20230052

COMPOSIçãO QUíMICA E ATIVIDADES FOTOPROTETORA E ANTIRADICALAR IN VITRO DOS GALHOS DE Platonia insignis (CLUSIACEAE)
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Silva, Andréia G. A.

; Moreira, Rodrigo de A.

; Sousa, Renato Pinto de

; S. M. Filho, Evaldo dos

; Veras, Marcia D. A.

; Chaves, Mariana Helena

; Freitas, Sâmya D. L.

Química Nova

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aug 2021, Volume 44 N. 8 Pages 954 - 962

Abstract: Pt | Text: Pt | PDF: Pt

CHEMICAL COMPOSITION AND PHOTOPROTECTIVE AND ANTIRADICAL ACTIVITIES OF THE BRANCHES OF Platonia insignis (CLUSIACEAE). The chemical study of the branches of Platonia insignis enabled the isolation of the biflavonoid morelloflavone and the identification, by mass spectrometry, of over 9 polyphenols, including eight biflavonoids, one benzophenone, and one xanthone. The in vitro biological tests of solar photoprotection and antiradical activities against the crude extract and Hex and AcOEt fractions showed relevant results, which confirm the high pharmaceutical potential of the species.

https://doi.org/10.21577/0100-4042.20170761 72 downloads

O PET-Saúde Interprofissionalidade e as ações em tempos de pandemia: perspectivas docentes
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Chriguer, Rosangela Soares

; Aveiro, Mariana Chaves

; Batista, Sylvia Helena Souza da Silva

; Garbus, Rafaela Barroso de Souza Costa

Interface - Comunicação, Saúde, Educação

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2021, Volume 25 Suppl. 1 elocation e210153

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

O Programa de Educação pelo Trabalho para Saúde (PET-Saúde) é uma política indutora que fomenta o aprendizado por vivências problematizadoras nos locais de trabalho em saúde com foco na interprofissionalidade. O objetivo do presente trabalho foi relatar a experiência do PET-Saúde Interprofissionalidade durante a pandemia de Covid-19, na perspectiva docente. Desenvolver o PET-Saúde com estudantes, preceptores, equipes dos serviços e usuários demandou (re)descobrir possibilidades das tecnologias de informação e comunicação e o aprendizado da produção de “novas presenças” sem desistir da ação coletiva, participativa e composta pelos diferentes saberes. Apreendeu-se o desenvolvimento de competências como escuta qualificada para resolução de conflitos, comunicação interprofissional e liderança colaborativa. Este PET-Saúde mostrou-se um disparador na formação em saúde, conectando universidade, rede de saúde e comunidade; e contribuindo para o desenvolvimento de competências colaborativas e um espaço de acolhimento para as situações vivenciadas.

The Program ‘Education through Work for Health’ (PET-Health) is a nudging policy that provides learning through problematizing experiences in health workplaces, with a focus on interprofessionality. The aim was to report the experience of PET-Health Interprofessionality during the Covid-19 pandemic, from the teachers' perspective. The development of PET-Health with students, tutors, teams from the health system and users demanded, (re) discovering possibilities of information and communication technologies, learning to produce “new presences”, without giving up the collective, participatory action, composed by different knowledge. There was learning of development of skills such as qualified listening for conflict resolution, interprofessional communication and collaborative leadership. This PET-Health proved to be a triggering event towards health education, connecting university, health network and community, and contributed to the development of collaborative skills and constituted a welcoming space for the situations experienced.

El Programa de Educación por el Trabajo para Salud (PET-Saúde) es una política inductora que fomenta el aprendizaje por vivencias problematizadoras en los locales de trabajo en salud con enfoque en la Interprofesionalidad. El objetivo fue relatar la experiencia del PET-Saúde Interprofesionalidad durante la pandemia de Covid-19, desde la perspectiva docente. Desarrollar el PET-Saúde con estudiantes, preceptores, equipos de los servicios y usuarios demandó (re)descubrir posibilidades de las tecnologías de información y comunicación, aprendiendo a producir “nuevas presencias”, sin desistir de la acción colectiva, participativa, compuesta por los diferentes saberes. Se aprendió a desarrollar competencias tales como escuchar de forma calificada para la resolución de conflictos, la comunicación interprofesional y el liderazgo colaborativo. Este PET-Saúde se mostró un gatillo en la formación en salud, conectando universidad, red de salud y comunidad, contribuyendo al desarrollo de competencias colaborativas y un espacio de acogida para las situaciones vividas.

https://doi.org/10.1590/interface.210153

Dehydrobufotenin extracted from the Amazonian toad Rhinella marina (Anura: Bufonidae) as a prototype molecule for the development of antiplasmodial drugs
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Banfi, Felipe Finger

; Krombauer, Gabriela Camila

; Fonseca, Amanda Luisa da

; Nunes, Renata Rachide

; Andrade, Silmara Nunes

; Rezende, Millena Alves de

; Chaves, Mariana Helena

; Monção Filho, Evaldo dos Santos

; Taranto, Alex Guterres

; Rodrigues, Domingos de Jesus

; Vieira Júnior, Gerardo Magela

; Castro, Whocely Victor de

; Varotti, Fernando de Pilla

; Sanchez, Bruno Antonio Marinho

Journal of Venomous Animals and Toxins including Tropical Diseases

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2021, Volume 27 elocation e20200073

Abstract: En | Text: En | PDF: En

Abstract Background: The resistance against antimalarial drugs represents a global challenge in the fight and control of malaria. The Brazilian biodiversity can be an important tool for research and development of new medicinal products. In this context, toxinology is a multidisciplinary approach on the development of new drugs, including the isolation, purification, and evaluation of the pharmacological activities of natural toxins. The present study aimed to evaluate the cytotoxicity, as well as the antimalarial activity in silico and in vitro of four compounds isolated from Rhinella marina venom as potential oral drug prototypes. Methods: Four compounds were challenged against 35 target proteins from P. falciparum and screened to evaluate their physicochemical properties using docking assay in Brazilian Malaria Molecular Targets (BraMMT) software and in silico assay in OCTOPUS® software. The in vitro antimalarial activity of the compounds against the 3D7 Plasmodium falciparum clones were assessed using the SYBR Green I based assay (IC50). For the cytotoxic tests, the LD50 was determined in human pulmonary fibroblast cell line using the [3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) assay. Results: All compounds presented a ligand-receptor interaction with ten Plasmodium falciparum-related protein targets, as well as antimalarial activity against chloroquine resistant strain (IC50 = 3.44 μM to 19.11 μM). Three of them (dehydrobufotenine, marinobufagin, and bufalin) showed adequate conditions for oral drug prototypes, with satisfactory prediction of absorption, permeability, and absence of toxicity. In the cell viability assay, only dehydrobufotenin was selective for the parasite. Conclusions: Dehydrobufotenin revealed to be a potential oral drug prototype presenting adequate antimalarial activity and absence of cytotoxicity, therefore should be subjected to further studies.

https://doi.org/10.1590/1678-9199-jvatitd-2020-0073 992 downloads

Elaboration and validation of a protocol for safe administration of enteral nutrition in hospitalized patients
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Macedo, Andréia Barcellos Teixeira

; Assis, Michelli Cristina Silva de

; Milioni, Kelly Cristina

; Canto, Débora Francisco do

; Souza, Célia Mariana Barbosa de

; Chaves, Enaura Helena Brandão

Revista Gaúcha de Enfermagem

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2021, Volume 42 N. spe elocation e20200181

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: Descrever a elaboração e validação de um protocolo para administração de nutrição enteral. Método: Estudo de validação por consenso de especialistas conduzido em um hospital universitário. A construção ocorreu após revisão da literatura. A validação foi norteada pela ferramenta plan, do, study and act. Para validação do protocolo final foi considerado consenso de 100%. Após a implantação, precedida de capacitação, ocorreu a avaliação por meio de indicadores. Resultados: O protocolo descreve as ações que guiam a equipe de enfermagem na nutrição enteral. Na validação, ocorreu consenso de 100% nos itens do protocolo. A capacitação presencial reuniu 425 participantes em 80 encontros. Após o período piloto, a taxa de cuidado ao paciente com nutrição enteral aumentou de 39,5% para 73,3%. Houve redução de 41 horas no tempo para liberação do laudo do raio X. Conclusão: O protocolo forneceu elementos para a prevenção de eventos adversos em pacientes com nutrição enteral.

ABSTRACT Objective: To describe the elaboration and validation of a protocol for administration of enteral nutrition. Method: Validation study by consensus of experts conducted in a university hospital. The construction took place after literature review. The validation was guided by the tool: plan, do, study and act. For validation of the final protocol, 100% consensus was considered. After implementation, preceded by training, evaluation was carried out by using indicators. Results: The protocol describes the actions that guide the nursing team in enteral nutrition. In the validation, there was a 100% consensus on the protocol items. The presential training brought together 425 participants in 80 meetings. After the pilot period, the rate of care for patients with enteral nutrition increased from 39.5% to 73.3%. There was a reduction of 41 hours in the time to release the X-ray report. Conclusion: The protocol provided elements for the prevention of adverse events in patients with enteral nutrition.

RESUMEN Objetivo: Describir la elaboración y validación de un protocolo para la administración de nutrición enteral. Método: Estudio de validación por consenso de expertos realizado en un hospital universitário. La construcción se llevó a cabo después de revisar la literatura. La validación estuvo guiada por la herramienta plan, do, study and act. Para la validación del protocolo final se considero un consenso del 100%. Después de la implementación, precedida por la capacitación, se llevó a cabo la evaluación mediante indicadores. Resultados: El protocolo describe las acciones que orientan al equipo de enfermería en nutrición enteral. En la validación , hubo un consenso del 100% en los ítems del protocolo. La información presencial reunió a 425 participantes en 80 reuniones. Después del período piloto, la tasa de atención a los pacientes con nutrición enteral aumento del 39,5% al 73,3%. Hubo una redución de 41 horas en el tiempo para publicar el informe de rayos X. Conclusión: El protocolo aportó elementos para la prevención de eventos adversos en pacientes con nutrición enteral.

https://doi.org/10.1590/1983-1447.2021.20200181 973 downloads

Elaboration and validation of a protocol for safe administration of enteral nutrition in hospitalized patients
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Macedo, Andréia Barcellos Teixeira

; Assis, Michelli Cristina Silva de

; Milioni, Kelly Cristina

; Canto, Débora Francisco do

; Souza, Célia Mariana Barbosa de

; Chaves, Enaura Helena Brandão

Revista Gaúcha de Enfermagem

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2021, Volume 42 N. spe elocation e20200181

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

https://doi.org/10.1590/1983-1447.2021.20200181 79 downloads

O PET-Saúde Interprofissionalidade e as ações em tempos de pandemia: perspectivas docentes
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Chriguer, Rosangela Soares

; Aveiro, Mariana Chaves

; Batista, Sylvia Helena Souza da Silva

; Garbus, Rafaela Barroso de Souza Costa

Interface - Comunicação, Saúde, Educação

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2021, Volume 25 Suppl. 1 elocation e210153

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/interface.210153

[SciELO Preprints] - Elaboration and validation of a protocol for safe administration of enteral nutrition in hospitalized patients
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Macedo, Andréia Barcellos Teixeira Assis, Michelli Cristina Silva de Milioni, Kelly Cristina Canto, Débora Francisco Martins, Celia Mariana Barbosa Chaves, Enaura Helena Brandão

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Publication date: 2020-11-24

Abstract: En Es Pt

Objective: To describe the elaboration and validation of a protocol for administration of enteral nutrition. Method: Validation study by consensus of experts conducted in a university hospital. The construction took place after literature review. The validation was guided by the tool: plan, do, study and act. For validation of the final protocol, 100% consensus was considered. After implementation, preceded by training, evaluation was carried out by using indicators. Results: The protocol describes the actions that guide the nursing team in enteral nutrition. In the validation, there was a 100% consensus on the protocol items. The presential training brought together 425 participants in 80 meetings. After the pilot period, the rate of care for patients with enteral nutrition increased from 39.5% to 73.3%. There was a reduction of 41 hours in the time to release the X-ray report. Conclusion: The protocol provided elements for the prevention of adverse events in patients with enteral nutrition. Keywords: Protocols. Enteral nutrition. Nursing care.

RESUMENObjetivo: Describir la elaboración y validación de un protocolo para la administración de nutrición enteral.Método: Estudio de validación por consenso de expertos realizado en un hospital universitário. La construcción se llevó a cabo después de revisar la literatura. La validación estuvo guiada por la herramienta planificar, hacer, estudiar y actuar. Para la validación del protocolo final se considero un consenso del 100%. Después de la implementación, precedida por la capacitación, se llevó a cabo la evaluación mediante indicadores.Resultados: El protocolo describe las acciones que orientan al equioo de enfermería en nutrición enteral. En la validación , hubo un consenso del 100% en los ítems del protocolo. La información presencial reunió a 425 participantes en 80 reuniones. Después del período piloto, la tasa de atención a los pacientes con nutrición enteral aumento del 39,5% al 73,3%. Hubo una redución de 41 horas en el tempo para publicar el informe de rayos X.Conclusión: El protocolo aportó elementos para la prevención de eventos adversos en pacientes con nutrición enteral.Palabras clave: Protocolos. Nutrición enteral. Atención de enfermería.

RESUMO Objetivo: Descrever a elaboração e validação de um protocolo para administração de nutrição enteral. Método: Estudo de validação por consenso de especialistas conduzido em um hospital universitário. A construção ocorreu após revisão da literatura. A validação foi norteada pela ferramenta plan, do, study and act. Para validação do protocolo final foi considerado consenso de 100%. Após a implantação, precedida de capacitação, ocorreu a avaliação por meio de indicadores.   Resultados: O protocolo descreve as ações que guiam a equipe de enfermagem na nutrição enteral. Na validação, ocorreu consenso de 100% nos itens do protocolo. A capacitação presencial reuniu 425 participantes em 80 encontros. Após o período piloto, a taxa de cuidado ao paciente com nutrição enteral aumentou de 39,5% para 73,3%. Houve redução de 41 horas no tempo para liberação do laudo do raio X. Conclusão: O protocolo forneceu elementos para a prevenção de eventos adversos em pacientes com nutrição enteral. Palavras-chave: Protocolos. Nutrição enteral. Cuidados de enfermagem.

https://doi.org/10.1590/1983-1447.2021.20200181

Atualização das Diretrizes em Cardiogeriatria da Sociedade Brasileira de Cardiologia – 2019
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Feitosa Filho, Gilson Soares

; Peixoto, José Maria

; Pinheiro, José Elias Soares

; Afiune Neto, Abrahão

; Albuquerque, Afonso Luiz Tavares de

; Cattani, Álvaro César

; Nussbacher, Amit

; Camarano, Ana Amelia

; Sichinels, Angela Hermínia

; Sousa, Antonio Carlos Sobral

; Alencar Filho, Aristóteles Comte de

; Gravina, Claudia F.

; Sobral Filho, Dario Celestino

; Pitthan, Eduardo

; Costa, Elisa Franco de Assis

; Duarte, Elizabeth da Rosa

; Freitas, Elizabete Viana de

; Moriguchi, Emilio Hideyuki

; Mesquita, Evandro Tinoco

; Fernandes, Fábio

; Fuchs, Felipe Costa

; Feitosa, Gilson Soares

; Pierre, Humberto

; Pereira Filho, Ilnei

; Helber, Izo

; Borges, Jairo Lins

; Garcia, Jéssica Myrian de Amorim

; Souza, José Antonio Gordillo de

; Zanon, José Carlos da Costa

; Alves, Josmar de Castro

; Mohallem, Kalil Lays

; Chaves, Laura Mariana de Siqueira Mendonça

; Moura, Lídia Ana Zytynski

; Silva, Márcia Cristina Amélia da

; Toledo, Maria Alice de Vilhena

; Assunção, Maria Elisa Lucena Sales de Melo

; Wajngarten, Mauricio

; Gonçalves, Mauro José Oliveira

; Lopes, Neuza Helena Moreira

; Rodrigues, Nezilour Lobato

; Toscano, Paulo Roberto Pereira

; Rousseff, Pedro

; Maia, Ricardo Antonio Rosado

; Franken, Roberto Alexandre

; Miranda, Roberto Dischinger

; Gamarski, Roberto

; Rosa, Ronaldo Fernandes

; Santos, Silvio Carlos de Moraes

; Galera, Siulmara Cristina

; Grespan, Stela Maris da Silva

; Silva, Teresa Cristina Rogerio da

; Esteves, William Antonio de Magalhães

Arquivos Brasileiros de Cardiologia

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may 2019, Volume 112 N. 5 Pages 649 - 705

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.5935/abc.20190086 15622 downloads

10.

Evaluation of antimutagenic and cytotoxic activity of skin secretion extract of Rhinella marina and Rhaebo guttatus (Anura, Bufonidae)
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OLIVEIRA, Angellica Fernandes de

; CASTOLDI, Lindsey

; VIEIRA JUNIOR, Gerardo Magela

; MONÇÃO FILHO, Evaldo dos Santos

; CHAVES, Mariana Helena

; RODRIGUES, Domingos de Jesus

; SUGUI, Marina Mariko

Acta Amazonica

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apr 2019, Volume 49 N. 2 Pages 145 - 151

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A secreção cutânea de anuros da família Bufonidae tem grande potencial na busca de novos compostos ativos para utilização como fármacos candidatos no tratamento de algumas doenças, entre elas o câncer. Neste contexto, este estudo teve como objetivo avaliar a atividade citotóxica e antimutagênica dos extratos da secreção da glândula parótida de Rhinella marina e Rhaebo guttatus, bem como a análise bioquímica de transaminases e creatinina séricas, para avaliar dano hepático e renal, respectivamente. A avaliação de citotoxicidade foi realizada pelo método colorimétrico baseado no MTT (3-[4, 5-dimethyl-2-thiazolyl]-2, 5-diphenyl-2H-tetrazolium bromide), com diferentes concentrações dos extratos em culturas de células do Tumor de Walker ou células esplênicas de rato e camundongo. O teste do micronúcleo foi realizado com camundongos Swiss machos que receberam tratamento oral com os extratos durante 15 dias, seguido de tratamento intraperitoneal com N-etil-N-nitrosuréia (50 mg kg-1). A frequência de eritrócitos policromáticos micronucleados (PCEMN) foi determinada em medula óssea. Os extratos apresentaram ação citotóxica nas células avaliadas. Houve uma redução significativa na frequência de PCEMN (R. marina = 56% e R. guttatus = 75%, p < 0,001), observando-se um potencial antimutagênico dos extratos. Os grupos tratados somente com os extratos apresentaram um aumento na frequência de PCEMNs, evidenciando um potencial mutagênico. As análises bioquímicas não apresentaram diferença significativa entre os tratamentos. Assim, nas condições experimentais testadas, as secreções cutâneas de R. marina e R. guttatus apresentaram potencial quimiopreventivo para câncer.

ABSTRACT The skin secretion from toads of the Bufonidae family has great potential in the search for new active compounds to be used as drug candidates in treating some diseases, among them cancer. In this context, this study aimed to evaluate the cytotoxic and antimutagenic activity of the parotoid gland secretion extracts of Rhinella marina and Rhaebo guttatus, as well as biochemically analyze transaminases and serum creatinine for liver and renal damage, respectively. Cytotoxicity was performed by the colorimetric method based on MTT (3- [4, 5-dimethyl-2-thiazolyl]-2, 5-diphenyl-2H-tetrazolium bromide) with different concentrations of the extracts in Walker or splenic tumor cell cultures from rats and mice. The micronucleus test was performed with male Swiss mice treated orally with the extracts for 15 days, and then intraperitoneally with N-ethyl-N-nitrosurea (50 mg kg-1). Micronucleated polychromatic erythrocytes (MNPCE) were evaluated in bone marrow. The extracts showed cytotoxic activity in the evaluated cells. There was a significant reduction in the frequency of MNPCE (R. marina = 56% and R. guttatus = 75%, p < 0.001), indicating antimutagenic potential of the extracts. The groups treated only with extract showed an increase in MNPCE frequency, evidencing mutagenic potential. Biochemical analyzes showed no significant difference between treatments. Thus, under our experimental conditions, the extracts of R. marina and R. guttatus skin secretions presented chemopreventive potential for cancer.

https://doi.org/10.1590/1809-4392201801751 2023 downloads

11.

Vasorelaxant activity and acute toxicity of the ethanolic extract of Zanthoxylum rhoifolium Lam leaves
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Silva, Joliane Carvalho

; Azevedo, Pedro Simão da Silva

; Souza, Fabiana de Moura

; Aragão, Kalynca Kayla Viana

; Sabino, Carla Kelly Barroso

; Carvalho, Gabriela Dantas

; Morais, Ilmara Cecília Pinheiro

; Mendes, Marcelo Bezerra

; Chaves, Mariana Helena

; Oliveira, Aldeídia Pereira de

Brazilian Journal of Pharmaceutical Sciences

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2019, Volume 55 elocation e17754

Abstract: En | Text: En | PDF: En

The study evaluated the vasorelaxant effect induced by the ethanolic extract of the leaves of Zanthoxylum rhoifolium Lam (EEtOH-Zr/leaves). Wistar rats were treated with the leaf extract containing a single dose of 2,000 mg / kg, v.o. After 14 days, the animals were anesthetized for blood collection and subsequent analysis of the biochemical parameters; they were then euthanized (sodium pentobarbital-100 mg/kg, i.p.) for the removal and morphological analysis of the heart, lung, liver and kidney. The vasorelaxation activity the and vascular reactivity of EEtOH-Zr/leaves were evaluated on artery mesenteric rings isolated from rats. The extract showed no signs of toxicity and no significant difference in the values of the biochemical parameters between the control group and the group of treated animals. In the evaluation of pharmacological activity in the smooth muscle, the EEtOH-Zr/leaves caused vasorelaxant effect on the tonic contraction induced by phenylephrine in mesenteric artery preparations in the presence (pD2=2.17±0.05 µg/mL; Emax=99.8±5.2%) and absence (pD2=2.14±0.05 µg/mL; Emax=95.3±6.4%) of the vascular endothelium. Oral administration of EEtOH-Zr/leaves reduced the contraction induced by the cumulative addition of PHE. It is concluded that the EEtOH-Zr/leaves promote vasorelaxation and reduce vascular reactivity of adrenergic alpha-1 agonist in the mesenteric artery. The results did not show toxic effects of the extract.

https://doi.org/10.1590/s2175-97902019000117754 1207 downloads

12.

Silver and gold nanoparticles from tannic acid: synthesis, characterization and evaluation of antileishmanial and cytotoxic activities
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LOPES, LOURDES C.S.

; BRITO, LUCAS M.

; BEZERRA, THAYLLAN T.

; GOMES, KLEYTON N.

; CARVALHO, FERNANDO A. DE A.

; CHAVES, MARIANA HELENA

; CANTANHÊDE, WELTER

Anais da Academia Brasileira de Ciências

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sep 2018, Volume 90 N. 3 Pages 2679 - 2689

Abstract: En | Text: En | PDF: En

Abstract Gold (Au0) and silver (Ag0) nanoparticles were synthesized using tannic acid (TA) as both reducing and stabilizer. Nanoparticles formation, stability, and interaction with TA were compared to citrate-coated nanoparticles and monitored by UV-Vis, zeta potential, and transmission electron microscopy. TA coating resulted in a red-shift and broadening of bands compared to citrate-coated nanoparticles (NPs-Cit). AgNPs-TA and AuNPs-TA are negatively charged with mean surface charge of -29.4 mV and -29.6 mV, respectively. TEM images showed polydispersety of AuNPs-TA (6-42 nm) and aggregation of AgNPs-TA (12-71 nm). In vitro assays of Leishmania amazonensis promastigotes showed an increment of antileishmanial activity for AgNPs-TA in relation to AgNPs-Cit, while AuNPs-TA and AuNPs-Cit did not affect the protozoas at tested concentrations. CC50 value for AgNPs-TA suggested that TA attenuates nanosilver toxicity comparatively to its precursor (Ag+). This investigation can contribute to the development of new, green, and fast produced drugs aiming at leishmaniasis treatment.

https://doi.org/10.1590/0001-3765201820170598 3682 downloads

13.

PHENOLIC DERIVATIVES AND ANTIOXIDANT ACTIVITY OF POLAR EXTRACTS FROM Bauhinia pulchella
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Carvalho, Adonias Almeida

; Santos, Lucivania Rodrigues dos

; Farias, Ruth Raquel Soares de

; Chaves, Mariana Helena

; Feitosa, Chistiane Mendes

; Vieira Júnior, Gerardo Magela

; Araújo, Mônica Regina Silva de

; Ferreira, Paulo Michel Pinheiro

; Pessoa, Claudia do Ó

Química Nova

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apr 2018, Volume 41 N. 4 Pages 405 - 411

Abstract: En | Text: En | PDF: En

A tea made with the leaves or stem bark of Bauhinia pulchella Benth (Fabaceae) is used in the treatment of diabetes. Ethanol (EEF) and aqueous (EAF) extracts were obtained from the leaves and the antioxidant and citotoxic activities were tested, as well as quantify the content of flavonoids and phenolic compounds (TPC). EEF and EAF showed similar profiles by HPLC, with the presence of three compounds. Column chromatography reverse phase (C18) and Sephadex LH-20, followed by semi preparative HPLC-C18 of EAF resulted in three flavonoids. Their structures were identified by 1H and 13C NMR as myricitrin (1), quercitrin (2) and afzelin (3). In assay of determination of reactive substances to thiobarbituric acid (TBARS), with DPPH, ABTS and nitric oxide (NO•) free radicals, EAF showed antioxidant potential higher than the EEF. This is the first report of the occurrence of the flavonoids 1-3, in the species B. pulchella. EEF and EAF were inactive in the cytotoxicity assays. In short, the polar extracts from the leaves of B. pulchella proved to be promising sources of biomolecules phenolic, with antioxidant potential, which may, in the future, be used as chemical markers for species and validation of therapeutic use.

https://doi.org/10.21577/0100-4042.20170183 1020 downloads

14.

Effects of ethanol extract of Cenostigma macrophyllum Tul. (caneleiro) on reproductive parameters of female rats
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Barbosa Santos, Denise

; Guerra de Oliveira, Jamylla Mirck

; Neto Bueno, Martins

; Bezerra Sales, Paulo Alex

; Sena Costa, Charllyton Luis

; Chaves, Mariana Helena

; Carvalho e Martins, Maria do Carmo

; Raposo Costa, Amilton Paulo

Revista Cubana de Plantas Medicinales

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sep 2015, Volume 20 N. 3

Abstract: En | Text: En | PDF: En

82 downloads

15.

Constituintes químicos, fenóis totais e atividade antioxidante de Sterculia striata St. Hil. et Naudin
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Costa, Danielly Albuquerque

; Chaves, Mariana Helena

; Silva, Wisllan Cesar Santos

; Cost, Charllyton Luis Sena

Acta Amazonica

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mar 2010, Volume 40 N. 1 Pages 207 - 212

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A investigação fitoquímica das cascas do caule de Sterculia striata St. Hil. et Naudin, através de métodos cromatográficos, conduziu ao isolamento dos esteróides sitosterol, estigmasterol e sitosterol-3-O-β-D-glicopiranosídeo, além de quatro triterpenóides pentacíclicos, o lupeol, 3-β-O-acil lupeol, lupenona e ácido betulínico. As estruturas desses compostos foram identificadas por análise dos espectros de RMN ¹H e 13C e comparações com dados da literatura. Para determinação do teor de fenóis totais do extrato etanólico de S. striata utilizou-se o reativo Folin Ciocalteu, enquanto na avaliação da atividade antioxidante empregou-se o radical livre DPPH. Este é o primeiro trabalho descrevendo o estudo químico com as cascas do caule desta espécie.

The phytochemical investigation of the stem bark of Sterculia striata St. Hil. et Naudin by chromatographic methods led to the isolation of sitosterol, stigmasterol and sitosterol-3-O-β-D-glucopyranoside, besides pentacyclic triterpenoids, lupeol, 3-β-O-acyl-lupeol, lupenone and betulinic acid. The structures of these compounds were identified by ¹H and 13C NMR spectral data analysis and comparison with literature data. For determining of the phenolic content of the etanolic extract of Sterculia striata we used the Folin Ciocalteu reagent, and for the evaluation of antioxidant activity, we utilized the DPPH free radical. This is the first work reporting the chemical study with the stem bark of this species.

https://doi.org/10.1590/S0044-59672010000100026 5946 downloads

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