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Inoculation effects of growthpromoting bacteria on corn root architecture: influence of nitrogen levels, bacterial populations, and plant genotypes
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Dias, Albiane Carvalho

; Alves, Gabriela Cavalcanti

; Silva, Thamires Ferreira Rodrigues da

; Reis, Veronica Massena

Revista Brasileira de Ciência do Solo

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2023, Volume 47 elocation e0230059

Abstract: En | Text: En | PDF: En

ABSTRACT Inoculating corn with diazotrophic bacteria as growth promoters has been demonstrated to be an efficient agricultural practice in Brazil, mainly due to the root stimulation they provide to plants. This study investigates the corn (Zea mays L.) root architecture in a greenhouse assay where A. baldaniorum Sp245 and H. seropedicae ZAE94 strains were inoculated and evaluated for 22 days under two N levels: 0.6 and 6 mmol L-1 of N. Short-term bioassays were conducted to assess the plant’s response to the addition of indole-acetic acid, two bacterial populations, and two corn genotypes, utilizing image capture software WinRhizo Pro. The growth and distribution of tips, crossing, and length of fine roots were determined to be the most sensitive aspects to inoculation and indole-acetic acid induction. These responses were influenced by the genotype and the number of bacterial cells present. Biomass accumulation analyses quantified these modifications after a 22-day period. Additionally, the growth response was found to be more significant when applying the Hs-ZAE94 strain to plants fertilized with a higher dose of nitrogen (6.0 mmol L-1), and this response was positively correlated with bioassay data. Selected strains used as an inoculant can improve root architecture and, consequently, the N use efficiency.

https://doi.org/10.36783/18069657rbcs20230059

Growth promotion in different Urochloa species inoculated with Azospirillum baldaniorum
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Gomes, Liliandra Barreto Emídio

; Silva, Thamires Ferreira Rodrigues da

; Alves, Gabriela Cavalcanti

; Reis, Veronica Massena

Pesquisa Agropecuária Brasileira

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2023, Volume 58 elocation e03079

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract The objective of this work was to evaluate inoculation response to Azospirillum baldaniorum strain Sp245 in 14 Urochloa cultivars. The evaluated cultivars were: Marandú, Xaraés, Paiaguás, Piatã, Basilisk, B140, Comum, Tupi, H47, Llanero, Ruziziensis, Ipyporã, Mulato, and Convert HD364. Three experiments were conducted to measure root traits: two using soil and one a sterile substrate. Compared with the control, a single application of A. baldaniorum Sp245 increases dry matter accumulation and number of roots in cultivars Marandú, Llanero, Ruziziensis, and Convert HD364. However, after inoculation, cultivars Xaraés and Ipyporã show some root traits with lower values.

Resumo O objetivo deste trabalho foi avaliar a resposta à inoculação da estirpe Sp245 de Azospirillum baldaniorum em 14 cultivares de Urochloa. As cultivares avaliadas foram: Marandú, Xaraés, Paiaguás, Piatã, Basilisk, B140, Comum, Tupi, H47, Llanero, Ruziziensis, Ipyporã, Mulato e Convert HD364. Foram conduzidos três experimentos para mensuração de parâmetros radiculares: dois em solo e um em substrato estéril. Em comparação ao controle, a aplicação única de A. baldaniorum Sp245 aumenta o acúmulo de massa seca e a quantidade de raízes das cultivares Marandú, Llanero, Ruziziensis e Convert HD364. No entanto, após a inoculação, as cultivares Xaraés e Ipyporã apresentam alguns parâmetros radiculares com valores menores.

https://doi.org/10.1590/s1678-3921.pab2023.v58.03079

Root development and nitrogen acquisition of maize inoculated with two species of diazotrophs
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Carvalho, Albiane Dias

; Alves, Gabriela Cavalcanti

; Alves, Bruno José Rodrigues

; Santos, Leandro Azevedo

; Reis, Veronica Massena

Bragantia

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2023, Volume 82 elocation e20230060

Abstract: En | Text: En | PDF: En

ABSTRACT Plant-growth-promoting bacteria of the genus Azospirillum and Herbaspirillum can improve crop yields of maize in tropical environments. The main mechanism proposed for its promotion is related to the auxins produced by these species. The aim of this study was to compare the maize growth response of inoculation using two species, Azospirillum baldaniorum Sp245 (Ab-Sp245) and Herbaspirillum seropedicae ZAE94 (Hs-ZAE94) during the initial growth under controlled conditions. A pot experiment was conducted with five harvests measuring bacterial counts, root morphology, biomass, and nitrogen content, and soluble metabolites for 38 days. Depending on the harvest period, a differential growth response between the two strains test was compared to the control. Plants use the bacterium applied to improve nitrogen acquisition and transform it into higher biomass and nitrogen accumulation, especially for Ab-Sp245. On the other side, Hs-ZAE94 altered the soluble metabolites resulting in higher NO3-, NH4+, and N-amino and lower soluble fractions compared to Ab-Sp245 and the control. The observed plant-bacteria interaction is closely fine-tuned and regulated by the strain used and differences in growth promotion effects cannot solely attributed to the root morphology.

https://doi.org/10.1590/1678-4499.20230060

Diretrizes brasileiras para o manejo de potenciais doadores de órgãos em morte encefálica. Uma força-tarefa composta por Associação de Medicina Intensiva Brasileira, Associação Brasileira de Transplantes de Órgãos, Brazilian Research in Critical Care Network e Coordenação Geral do Sistema Nacional de Transplantes
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Westphal, Glauco Adrieno

; Robinson, Caroline Cabral

; Cavalcanti, Alexandre Biasi

; Gonçalves, Anderson Ricardo Roman

; Guterres, Cátia Moreira

; Teixeira, Cassiano

; Stein, Cinara

; Franke, Cristiano Augusto

; Silva, Daiana Barbosa da

; Pontes, Daniela Ferreira Salomão

; Nunes, Diego Silva Leite

; Abdala, Edson

; Dal-Pizzol, Felipe

; Bozza, Fernando Augusto

; Machado, Flávia Ribeiro

; Andrade, Joel de

; Cruz, Luciane Nascimento

; Azevedo, Luciano César Pontes

; Machado, Miriam Cristine Vahl

; Rosa, Regis Goulart

; Manfro, Roberto Ceratti

; Nothen, Rosana Reis

; Lobo, Suzana Margareth

; Rech, Tatiana Helena

; Lisboa, Thiago Costa

; Colpani, Verônica

; Falavigna, Maicon

Revista Brasileira de Terapia Intensiva

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jan 2021, Volume 33 N. 1 Pages 1 - 11

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Fornecer recomendações para nortear o manejo clínico do potencial doador em morte encefálica. Métodos: O presente documento foi formulado em dois painéis compostos por uma força tarefa integrada por 27 especialistas de diferentes áreas que responderam a questões dirigidas aos seguintes temas: ventilação mecânica, hemodinâmica, suporte endócrino-metabólico, infecção, temperatura corporal, transfusão sanguínea, e uso de checklists. Os desfechos considerados foram: parada cardíaca, número de órgãos retirados ou transplantados e função/sobrevida dos órgãos transplantados. A qualidade das evidências das recomendações foi avaliada pelo sistema Grading of Recommendations Assessment, Development, and Evaluation. Resultados: Foram geradas 19 recomendações a partir do painel de especialistas. Dessas, 7 foram classificadas como fortes, 11 fracas e uma foi considerada boa prática clínica. Conclusão: Apesar da concordância entre os membros do painel em relação à maior parte das recomendações, o grau de recomendação é fraco em sua maioria.

Abstract Objective: To contribute to updating the recommendations for brain-dead potential organ donor management. Methods: A group of 27 experts, including intensivists, transplant coordinators, transplant surgeons, and epidemiologists, answered questions related to the following topics were divided into mechanical ventilation, hemodynamics, endocrine-metabolic management, infection, body temperature, blood transfusion, and checklists use. The outcomes considered were cardiac arrests, number of organs removed or transplanted as well as function / survival of transplanted organs. The quality of evidence of the recommendations was assessed using the Grading of Recommendations Assessment, Development, and Evaluation system to classify the recommendations. Results: A total of 19 recommendations were drawn from the expert panel. Of these, 7 were classified as strong, 11 as weak and 1 was considered a good clinical practice. Conclusion: Despite the agreement among panel members on most recommendations, the grade of recommendation was mostly weak.

https://doi.org/10.5935/0103-507x.20210001 742 downloads

The influence of dehydroepiandrosterone on effector functions of neutrophils
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Brauer, Verônica Soares

; Zambuzi, Fabiana Albani

; Espíndola, Milena Sobral

; Cavalcanti Neto, Marinaldo Pacífico

; Prado, Morgana Kelly Borges

; Cardoso, Priscilla Mariane

; Soares, Luana Silva

; Galvao-Lima, Leonardo Judson

; Leopoldino, Andréia Machado

; Cardoso, Cristina Ribeiro de Barros

; Frantz, Fabiani Gai

Brazilian Journal of Pharmaceutical Sciences

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2021, Volume 57 elocation e19139

Abstract: En | Text: En | PDF: En

Dehydroepiandrosterone (DHEA) is a steroid hormone secreted by the adrenal glands, gonads and brain. It is a precursor to sex hormones and also is known to have immune modulatory activity. However, little is known about the relationship between DHEA and neutrophils and thus our study evaluates the influence of DHEA in the effector functions of neutrophils. Human neutrophils were treated in vitro with DHEA and further infected with Salmonella enterica serovar Typhimurium. The treatment of neutrophils with 0.01 μM of DHEA increased the phagocytosis of Salmonella independent of TLR4 as the treatment did not modulate the TLR4 expression. Additionally, DHEA caused a decrease in ROS (reactive oxygen species) production and did not influence the formation of the neutrophil extracellular trap (NET). Steroid treated neutrophils, infected or stimulated with LPS (lipopolysaccharide), showed reduced production of IL-8, compared to untreated cells. Also, the protein levels of p-NFκB were decreased in neutrophils treated with DHEA, and this reduction could explain the reduced levels of IL-8. These results led us to conclude that the steroid hormone DHEA has important modulatory functions in neutrophils.

https://doi.org/10.1590/s2175-97902020000419139 1 downloads

GRAIN YIELD OF MAIZE INOCULATED WITH DIAZOTROPHIC BACTERIA WITH THE APPLICATIONOF NITROGEN FERTILIZER
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ALVES, GABRIELA CAVALCANTI

; SOBRAL, LAFAYETTE FRANCO

; REIS, VERONICA MASSENA

Revista Caatinga

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sep 2020, Volume 33 N. 3 Pages 644 - 652

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Aumentar a produtividade de milho em condições de clima e solo do nordeste brasileiro podem ser atingida com a utilização de insumos biológicos acoplado a aplicação de menores doses de N -fertilizante. O objetivo deste trabalho foi avaliar o rendimento de grãos de milho inoculado com duas espécies de bactérias diazotróficas combinadas com doses de N-fertilizante durante três anos consecutivos em um Cambissolo no estado de Sergipe, Brasil. Duas espécies de bactérias foram utilizadas: Azospirillum brasilen se estirpe BR11005 (Sp245) e Herbaspirillum seropedicae BR11147 (ZAE94) e as doses crescentes de ureia de 0, 100, 200 e 300 kg ha-1. Sob condições de campo houve limitação do rendimento dependendo do ano agrícola e regime hídrico. A inoculação, associada a uma dose de 100 kg ha-1 N com as estirpes BR11147 e BR11005, aumentou a produtividade em 1.230 e 614 kg ha-1, respectivamente; sendo 37% e 19% maior que o controle não inoculado. Na ausência do fertilizante também foi observado incremento da produtividade no milho inoculado com BR11147 de 18% e no teor de N na folha índice pela inoculação da BR11145 em 10% comparado ao controle.

ABSTRACT Increasing the crop yield of maize planted in the climate and soil conditions of the northeast region of Brazil can be accomplished with the use of biological inputs coupled with the application of lower doses of nitrogen (N) fertilizer. The objective of this work was to evaluate the yield of maize inoculated with two diazotrophic bacterial species under different N rates, during three consecutive years in an Inseptisol of Sergipe state, Brazil. The two bacterial species used were Azospirillum brasilense BR11005 (Sp245) and Herbaspirillum seropedicae BR11147 (ZAE94). N was applied in the form of urea at 0, 100, 200, and 300 kg ha-1. Under field conditions and depending on the year, the crop yield was limited by the rainfall regime. The inoculation associated with the 100 kg ha-1 N treatment with BR11147 and BR11005, increased productivity by 1,230 kg ha-1 and 614 hg ha-1, respectively. This corresponded to a 37% and 19% productivity increase, respectively, compared to the productivity of the uninoculated control. At zero N, inoculation increased grain yield of maize plants inoculated with BR11147 by 18%. Additionally, the N content of the index leaf inoculated with BR11005 increased by 10% over that of the uninoculated control.

https://doi.org/10.1590/1983-21252020v33n307rc 926 downloads

Challenges and opportunities in the science of research to practice: lessons learned from a randomized controlled trial of a sexual risk-reduction intervention for psychiatric patients in a public mental health system
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Wainberg, Milton L.

; Mann, Claudio G.

; Norcini-Pala, Andrea

; McKinnon, Karen

; Pinto, Diana

; Pinho, Veronica

; Cavalcanti, Maria T.

; Cheng-Shiun, Leu

; Guimarães, Mark D.

; Mattos, Paulo

; Hughes, Elizabeth

; Palinkas, Lawrence A.

; Otto-Salaj, Laura

; Remien, Robert H.

; Cournos, Francine

Brazilian Journal of Psychiatry

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aug 2020, Volume 42 N. 4 Pages 349 - 359

Abstract: En | Text: En | PDF: En

Objective: Human immunodeficiency virus (HIV) prevention efficacy trials with psychiatric patients have been conducted in research settings in high-resourced countries, establishing short-term efficacy for reducing sexual risk behavior. None has been implemented within systems of care. In the last decade, overcoming this research-to-practice gap has become a focus of implementation science. This paper describes the first and only HIV Prevention intervention trial for psychiatric patients conducted in real-world outpatient psychiatric settings facilitated by trained clinic-based providers. Methods: The HIV Prevention intervention, which uses the Information-Motivation-Behavioral Skills model to achieve sexual risk-reduction, was rigorously adapted to the local context and clinic services’ needs. Participants from eight clinics were randomized to HIV Prevention or Health Promotion conditions. Results: HIV Prevention participants showed significant improvement in Information-Motivation-Behavioral domains; in this group, behavioral intentions were associated with significantly fewer unprotected sex occasions, but reduction of unprotected sex occasions was similar in both conditions. Conclusion: Our trial was conducted before implementation studies became widely funded. Transporting an intervention to a new culture or into real-world practice settings may require adaptations. Our results demonstrate that clear guidelines are needed regarding whether to conduct efficacy, effectiveness, and/or implementation research as the most appropriate next step. Clinical trial registration: NCT00881699

https://doi.org/10.1590/1516-4446-2019-0737 567 downloads

Occupational risks of commercial restaurant workers in the metropolitan region of Recife-PE
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Paes, Isabella Carla Ehrhardt

; Guilherme, Ruth Cavalcanti

; Livera, Alda Veronica de Souza

; Valle, Rafael Guilherme Ribeiro do

; Silveira, Karina Correia da

Gestão & Produção

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2020, Volume 27 N. 3 elocation e4330

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: Com o ritmo de vida moderno e acelerado, o número de pessoas que realizam refeições fora casa aumentou, consequentemente houve avanço da demanda de trabalho dos estabelecimentos do setor de refeições coletivas, fazendo com que os ambientes de trabalho se tornem susceptíveis ao surgimento de riscos ocupacionais que podem comprometer a saúde física, mental e social dos trabalhadores. No intuito de amenizar esses riscos, é preciso ter o conhecimento do quanto eles podem interferir na qualidade de vida e de trabalho dos colaboradores. Considerando esses aspectos, foram avaliados os riscos ocupacionais em dois restaurantes da região metropolitana do Recife-PE. Para avaliação desses foram estudados os níveis de ruído, calor e iluminação. Foram também avaliados os riscos químicos e a relação físico-ergonômica. Foi observado em todas as análises feitas, algum tipo de desconforto aos colaboradores. Na análise de ruído foi verificado desconforto, onde o garçom era exposto a níveis de 83 dB, na exposição ao calor a área de cocção contribuiu para o desconforto térmico, onde foi encontrada a exposição de 30,7 IBTUG e a iluminação insuficiente na área de lavagem de panelas, com 86 lux. Riscos provenientes do uso incorreto de EPI’S e falta destes foram encontrados na manipulação de produtos químicos e nos riscos ergonômicos foi observada inadequação da altura de bancadas para execução do trabalho. A partir desses resultados se torna fundamental a promoção de medidas corretivas para proporcionar um ambiente de trabalho confortável com diminuição do desgaste para o colaborador, de maneira que não haja consequências negativas para o mesmo, para a empresa e também ao cliente.

Abstract: With the modern and fast pace of life, the number of people who eat out has increased; consequently there has been an increase in the demand for work in establishments in the collective meals sector, making work environments susceptible to the emergence of occupational risks which may compromise the physical, mental and social health of workers. In order to mitigate these risks, one must have the knowledge of how they can interfere in the quality of life and work of the employees. Considering these aspects, occupational risks were evaluated in two restaurants in the metropolitan area of Recife-PE. For the evaluation of these were studied the levels of noise, heat and illumination. The chemical risks and physical-ergonomic relationship were also evaluated. It was observed in all the analyzes made, some type of discomfort to the collaborators. The noise analysis showed discomfort, where the waiter was exposed to levels of 83 dB, in the heat exposure the cooking area contributed to the thermal discomfort, where the exposure of 30.7 IBTUG was found and insufficient lighting in the area of washing pots with 86 lux. Risks arising from the incorrect use of PPE's and lack of these were found in the handling of chemicals and in the ergonomic risks was observed inadequacy of the height of worktops. From these results, it is fundamental to promote corrective measures to provide a comfortable work environment with reduced wear for the employee, so that there are no negative consequences for the company, as well as the customer.

https://doi.org/10.1590/0104-530x4330-20 1150 downloads

Avaliação da degradação de propriedades de forma de agregados
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Cavalcanti, Henrique

; Bessa, Iuri

; Ibiapina, Daniele

; Branco, Verônica Castelo

Matéria (Rio de Janeiro)

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2020, Volume 25 N. 1 elocation e-12555

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO As propriedades de forma de agregados (forma, angularidade e textura superficial) influenciam a textura do revestimento asfáltico, parâmetro que está diretamente ligado à aderência pneu-pavimento, à estabilidade e à segurança rodoviária. Diante da importância de se estudar essas características, este trabalho tem como objetivo principal avaliar o efeito do desgaste de agregados nas suas propriedades de forma. Para tanto, as propriedades de forma de agregados de três diferentes tamanhos foram analisadas por meio do uso dos métodostradicionais e através de uma técnica de Processamento Digital de Imagens (PDI). Essas propriedades foram analisadas com o uso do Aggregate Image Measurement System 2 (AIMS2), antes e após a alteração das mesmas a partir do uso do Micro Deval (MD) e do equipamento de abrasão Los Angeles (LA), além do ensaio convencional de obtenção de Volume de Vazios (VV) não compactados. A angularidade das partículas diminuiu durante o processo de degradação, independente do equipamento utilizado nas análises. A esfericidade dos agregados desgastados no MD não sofreu variações significativas. Esse fato pode ter acontecido devido à pequena carga abrasiva utilizada no ensaio. A textura superficial, avaliada após o ensaio de abrasão Los Angeles, não apresentou variação significativa, uma vez que nesse ensaio há uma tendência de quebra das partículas dos agregados, fato que está mais relacionado à sua forma. Além disso, os resultados encontrados mostraram que o tamanho dos agregados e a presença de água influenciaram o processo de desgaste dos agregados. A combinação da caracterização por imagem das propriedades de forma de agregados e a utilização de processos mecânicos laboratoriais que sejam capazes de alterar essas propriedades pode se tornar uma solução adequada para a previsão do desempenho de pavimentos em relação à perda de aderência ao longo do tempo.

ABSTRACT The aggregates shape properties (form, angularity, and surface texture) have an influence on the asphalt pavement surface texture, which is directly related to tire-pavement adhesion, to stability and to road safety. Due to the importance of studying these characteristics, this research has the main objective of evaluating the effect of aggregate degradation on their shape properties. In order to achieve this, the shape properties of aggregates with three different sizes were analyzed by means of traditional methods and also with the use of aDigital Image Processing (DIP) technique. These properties were analyzed with the use of the Aggregate Image Measurement System 2 (AIMS2), before and after the use of the Micro Deval (MD) and the Los Angeles abrasion equipment, besides the conventional test of uncompacted void content. The aggregates particles angularity values decreased during the degradation process for both equipment used in the analyses. The aggregates sphericity after the use of MD did not change significantly. This could be explained because smaller abrasive charges are used in this particular test. The surface texture evaluated after the Los Angeles abrasion test did not vary significantly, which can be explained due to the tendency of breakage during the test, a process that is more related changes in form conditions. Furthermore, the results showed that the aggregate size and the presence of water influenced the degradation processes of the aggregates. The combination of the characterization of aggregate shape properties by means of image techniques with the use of laboratorial mechanical processes that are capable of modifying these properties might be an adequate solution for the prediction of asphalt pavements performance in relation to adhesion loss throughout the time.

https://doi.org/10.1590/s1517-707620200001.0880 1687 downloads

10.

EXISTE ASSOCIAÇÃO ENTRE O USO DE GLICOCORTICOIDES E A PRESENÇA DE FRATURAS? ESTUDO COMPARATIVO EM UM HOSPITAL DE TRAUMA
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Sarinho, Emanuel Sávio Cavalcanti

; Melo, Verônica Maria Pinho Pessôa

; Viana, Marcelo Tavares

; Melo, Marina Maria Pessôa

Revista Paulista de Pediatria

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jan 2019, Volume 37 N. 1 Pages 4 - 10

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliar se houve associação entre a ocorrência de fratura após trauma físico e o uso de glicocorticoides nos 12 meses precedentes ao trauma, em crianças e adolescentes atendidos em uma emergência. Métodos: No período de abril a outubro de 2015 foi conduzido em uma emergência pediátrica um estudo tipo caso controle, em pacientes de 3 a 14 anos incompletos, vitimados por trauma físico, com e sem fratura. Os dados analisados foram obtidos pela consulta dos prontuários, pelo exame físico dos pacientes e por entrevista dos responsáveis, comparando-se uso de glicocorticoides nos últimos 12 meses, características demográficas, índice de massa corpórea, ingesta de leite, intensidade do trauma, prática de exercício físico e tabagismo passivo domiciliar nos dois grupos de pacientes. Resultados: Estudaram-se 104 pacientes com trauma físico, 50 com fratura e 54 sem fratura. O uso de glicocorticoides ocorreu em 15,4% dos pacientes estudados, sem diferença estatisticamente significante entre os dois grupos. A faixa etária de 10 a 14 anos incompletos, o trauma grave e a prática de exercício físico predominaram entre os pacientes com fratura. Conclusões: Este estudo não mostrou associação entre o uso prévio de glicocorticoides e a ocorrência de fraturas em crianças e adolescentes. A faixa etária de 10 a 14 anos incompletos, o trauma grave e a prática de exercício físico associaram-se com maior risco para fraturas.

ABSTRACT Objective: To assess the association between traumatic fractures and glucocorticoids taken 12 months prior to a trauma, in children and adolescents seen at an emergency room. Methods: A case-control study was conducted from April to October 2015, at a pediatric emergency hospital with patients aged 3- to 14 years-old, who had suffered physical trauma. Some of the patients had a fracture and some did not. The data analyzed were obtained from medical records, physical examination of the patients, and interview with the patients’ caregivers. Glucocorticoid use in the past 12 months, demographic variables, body mass index, milk intake, trauma intensity, physical activity and smoking in the household were compared between the two patient groups. Results: A total of 104 patients with physical trauma were studied - 50 had a fracture and 54 did not. Of all the patients, 15.4% had previously used glucocorticoids, and there were no statistically significant differences between the groups. The age range of 10- to 14 years-old, severe trauma and physical activity were more prevalent among patients with a bone fracture. Conclusions: This study did not find an association between previous glucocorticoid use and the occurrence of fractures in children and adolescents. The age range of 10- to 14 years-old, severe trauma, and physical activity were associated with an increased risk for fractures.

https://doi.org/10.1590/1984-0462/;2019;37;1;00001 1171 downloads

11.

Efecto de los antimaláricos sobre los diferentes dominios del índice de daño SLICC en pacientes de la cohorte GLADEL
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Pons-Estel, Guillermo J.

; Quintana, Rosana

; Wojdyla, Daniel

; Alarcón, Graciela S.

; Serrano, Rosa María

; Ugarte-Gil, Manuel

; Pimentel-Quiroz, Víctor

; Soriano, Enrique R.

; Catoggio, Luis J.

; Scolnik, Marina

; Sacnun, Mónica

; Saurit, Verónica

; Caeiro, Francisco

; Alvarellos, Alejandro

; Sarano, Judith

; García, Mercedes

; Onetti, Laura

; Drenkard, Cristina

; Berbotto, Guillermo

; Scherbarth, Hugo R.

; Sato, Emilia

; Bonfa, Eloisa

; Ferreira Borba, Eduardo

; Costallat, Lilian

; Xavier, Ricardo

; Tavares Brenol, Joao C.

; Da Silva, Nilzio A.

; Cavalcanti, Fernando

; Massardo, Loreto

; Jacobelli, Sergio

; Neira, Oscar

; Molina, José F

; Vásquez, Gloria

; Gómez-Puerta, José A.

; Alonso Gonzalez, Luis

; Iglesias Gamarra, Antonio

; Guibert-Toledano, Marlene

; Reyes, Gil A.

; Cardiel, Mario H.

; Pascual-Ramos, Virginia

; García de la Torre, Ignacio

; Barile, Leonor

; Silveira, Luis H.

; Amigo, Mary-Carmen

; Sauza del Pozo, María Josefina

; Acevedo-Vásquez, Eduardo M.

; Alfaro-Lozano, José

; Segami, María Inés

; Chacón-Díaz, Rosa

; Abadi, Isaac

; Esteva Spinetti, María H

; Pons-Estel, Bernardo A.

Revista argentina de reumatología

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sep 2018, Volume 29 N. 3 Pages 6 - 10

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Objective: To assess the effects of antimalarials (AM) over the items of the SLICC Damage Index (SDI). Methods: Patients with recent (≤2 years) diagnosis of systemic lupus erythematosus (SLE) from the GLADEL cohort were studied. End-point: increase in items SDI since cohort entry. Independent variables (socio-demographic, clinical, laboratory and treatment) were included. The effect of AM as a time dependent variable on most frequent SDI items (adjusting for potential confounders) was examined with a multivariable Cox regression model. Results: Of the 1466 patients included in this analysis, 1049 (72%) received AM with a median exposure time of 30 months (Q1-Q3: 11-57). Damage occurred in 665 (45%) patients during a median follow-up time of 24 months (Q1-Q3: 8-55). There were 301 integument, 208 renal, 149 neuropsychiatric, 98 musculoskeletal, 88 cardiovascular and 230 others less frequently represented damages. After adjusting for potential confounders at any time during follow-up, a lower risk of renal damage (HR 0.652; 95% CI: 0.472-0.901) and borderline for neuropsychiatric damage (HR 0.701, 95% CI: 0.481-1.024) was found. Conclusion: In the GLADEL cohort, after adjustment for possible confounding factors, AM were independently associated with a reduced risk of renal damage accrual.

Objetivos: Estimar el efecto de los antimaláricos (AM) sobre los diferentes dominios del índice de daño SLICC (SDI). Métodos: Se estudiaron pacientes con diagnóstico clínico reciente (≤2 años) de lupus eritematoso sistémico (LES) de la cohorte GLADEL. Variable de estudio: aumento en los dominios del SDI desde el ingreso a la cohorte. Variables independientes: características sociodemográficas, clínicas, laboratorio y tratamientos. El efecto de los AM, como variable dependiente del tiempo, sobre los dominios más frecuentes del SDI (ajustado por factores de confusión) fue examinado con un modelo de regresión de Cox multivariado. Resultados: De 1466 pacientes estudiados, 1049 (72%) recibieron AM con un tiempo medio de exposición de 30 meses (Q1-Q3: 11-57) y 665 pacientes (45%) presentaron daño durante un seguimiento medio de 24 meses (Q1-Q3: 8-55); 301 eventos fueron cutáneos, 208 renales, 149 neuropsiquiátricos, 98 musculoesqueléticos, 88 cardiovasculares y 230 otros. Después de ajustar por factores de confusión, el uso de AM se asoció a un menor riesgo de daño renal (HR 0,652; IC 95%: 0,472-0,901) y en el límite de la significancia estadística (HR 0,701, IC 95%: 0,481-1,024) para el dominio neuropsiquiátrico. Conclusión: En GLADEL, el uso de AM se asoció independientemente a un menor riesgo de daño acumulado renal.

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12.

Potencial de vazão ambiental: método participativo para estimar vazão ambiental em rios na Amazônia
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Santos, Paula Veronica Campos Jorge

; Cunha, Alan Cavalcanti

Engenharia Sanitaria e Ambiental

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feb 2018, Volume 23 N. 1 Pages 137 - 150

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O potencial de vazão ambiental (PVA) é um método alternativo de estimativa de vazão por considerar principalmente as características ecológicas, econômicas e culturais das bacias hidrográficas, reduzindo erros de estimativa na avaliação de impactos ambientais para implantação ou operação de usinas hidrelétricas (UHEs). O objetivo desta pesquisa foi adaptar a metodologia do PVA para grandes bacias da Amazônia usando abordagem holística. A metodologia de estimativa do PVA foi adaptada às bacias hidrográficas dos rios Tocantins, no Pará, Jari, no Amapá e Pará, e Araguari, no Amapá, em fase de operação e/ou instalação de UHEs. Os resultados sugerem que, nos rios Tocantins e Araguari, ambos sob influência de barramentos em operação, o parâmetro mais relevante do PVA foi o estresse hídrico. Diante dos impactos diretos dessas UHEs, a vazão é elevada e suficiente para manter o ecossistema ou a diversidade aquática durante o ano. Contudo, a resposta do método na bacia hidrográfica do rio Jari indicou o parâmetro dependência econômica como o mais crítico, já que o rio é intensamente utilizado para a locomoção pelos moradores do Pará e Amapá e, dessa forma, o cálculo da vazão por método não adequado comprometeria essa tão importante função do rio. Concluiu-se que o método PVA é uma ferramenta alternativa interessante à gestão de grandes bacias por ser flexível, adaptável e principalmente por permitir a participação dos agentes envolvidos nos processos decisórios.

ABSTRACT The potential of environmental flow (PVA) is an alternative method to estimate the flow as it mainly considers the ecological, economic and cultural characteristics of the basins, reducing estimation errors in the assessment of environmental impacts for deployment or operation of hydroelectric power plants (HPPs). The aim of this research was to adapt the PVA methodology for Amazon’s large basins using holistic approach. The methodology for estimating the PVA was adapted to the watersheds of the rivers Tocantins, in Pará, Jari, in Amapá and Pará, and Araguari, in Amapá, under operation and/or final installation of HPPs. The results suggest that, in the Tocantins and Araguari rivers, both under the influence of dams in operation, the most relevant parameter of PVA was water stress. Taking into account the direct impact of these HPPs, the flow rate is high enough to keep the ecosystem or aquatic diversity during the whole year. However, the response of the PVA in the Jari river basin, in the ultimate construction phase, the most relevant parameter was the economic dependence, because the priority is the fluvial transport, and, in this way, estimating the flow by a non-adequate method would jeopardize this very important function. We concluded that the PVA method is an interesting tool for managing large basins, because it is flexible, adaptable and especially allowing the participation of the agents involved in the decision making processes.

https://doi.org/10.1590/s1413-41522018140637 1772 downloads

13.

DOENÇA ÓSSEA INDUZIDA PELOS GLICOCORTICOIDES: MECANISMOS E IMPORTÂNCIA NA PRÁTICA PEDIÁTRICA
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Sarinho, Emanuel Sávio Cavalcanti

; Melo, Verônica Maria Pinho Pessoa

Revista Paulista de Pediatria

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jun 2017, Volume 35 N. 2 Pages 207 - 215

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Descrever os mecanismos pelos quais os glicocorticoides provocam osteoporose, com risco consequente de fraturas, integrando esse conhecimento a uma possível mudança de conduta dos profissionais de saúde. Fontes de dados: Foi realizada pesquisa aprofundada nas bases de dados (SciELO, PubMed, Medline e Scopus), buscando consensos, artigos de revisão, incluindo revisões sistemáticas e meta-análises, publicados em inglês, entre 2000 e 2016. As palavras-chaves utilizadas na busca foram glicocorticoides, esteroides, fraturas, osteoporose, saúde óssea, crianças e adolescentes. Síntese dos dados: A revisão foi dividida em quatro tópicos principais: 1) introdução, com breve enfoque nas fraturas em pediatria; 2) osteoporose em crianças e adolescentes, destacando-a como causa silenciosa de fraturas; 3) glicocorticoides e doença óssea secundária, com a descrição dos mecanismos deletérios desse grupo de esteroides na estrutura óssea; 4) efeitos moleculares do excesso de glicocorticoides no osso, com o detalhamento dos mecanismos nocivos a nível molecular do tecido ósseo. Conclusões: Os glicocorticoides em excesso determinam doença óssea precoce, favorecendo a ocorrência de fraturas. Dessa forma, uma criança ou adolescente que requer corticoterapia, sobretudo crônica e sistêmica, mas também em ciclos repetidos com doses cumulativas altas, necessita de cuidados e orientações relacionados à saúde óssea logo ao início do tratamento. Por outro lado, aqueles com fratura, mesmo entrelaçada a um trauma, podem sinalizar fragilidade óssea subjacente e desconhecida, incluindo a secundária ao uso de glicocorticoides e à deficiência de vitamina D.

ABSTRACT Objective: To describe mechanisms by which glucocorticoids cause osteoporosis, with fracture risk, combining this learning with a possible professional behavior change. Data sources: A systematic search on SciELO, PubMed, Scopus, and Medline databases was carried out for consensus, review articles, including systematic reviews and meta-analysis, which were published in English, between 2000 and 2016. Keywords used on the search were the following: glucocorticoids, fractures, osteoporosis, bone health, vitamin D, children, and adolescents. Data synthesis: The review was divided into four topics: 1) introduction, with a brief focus on pediatric fractures; 2) osteoporosis in children and adolescents, highlighting it as a silent cause of fractures; 3) glucocorticoids and secondary bone disease, describing deleterious mechanisms of this steroids group on bone structure; 4) molecular effects of glucocorticoids excess on bone, with details about the harmful mechanisms on bone molecular level. Conclusions: Glucocorticoids excess determines early bone disease, favoring the occurrence of fractures. Thus, a child or an adolescent who uses glucocorticoids, especially systemically and chronically, but also repeats cycles at high cumulative doses of the medication, needs care and guidance related to bone health at the onset of treatment. On the other hand, the presence of fractures, even if related to trauma, can be a sign of underlying and unknown bone fragility, which may be secondary to the use of glucocorticoids and/or vitamin D deficiency.

https://doi.org/10.1590/1984-0462;2017/;35;2;00007 4650 downloads

14.

Evaluation of cardiopulmonary parameters and recovery from anesthesia in cougars (Puma concolor) anesthetized with detomidine/ketamine and isoflurane or sevoflurane
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Albuquerque, Verônica B.

; Araújo, Marcelo A.

; Oliveira, Alice R.

; Cavalcanti, Guilherme

; Leal, Rodrigo C.

; Santos, Élson B.

; Cavalcanti, Álvaro R.

; Frazilio, Fabrício O.

Pesquisa Veterinária Brasileira

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jan 2016, Volume 36 N. 1 Pages 33 - 38

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: O objetivo do presente estudo foi avaliar os efeitos cardiorrespiratórios e a recuperação anestésica de onças-pardas (Puma concolor) submetidas à anestesia com detomidina/cetamina e isofluorano ou sevofluorano para avaliação ultrassonográfica abdominal. Para isso, foram utilizados 14 animais divididos aleatoriamente em dois grupos experimentais GISO (n=7) e GSEVO (n=7). Foram submetidos à contenção química com detomidina 0,15mg/kg associada à cetamina 5mg/kg pela via intramuscular, induzidos com propofol 2mg/kg pela via intravenosa e mantidos com isofluorano (GISO) ou sevofluorano. Foram avaliados os parâmetros: frequência cardíaca e respiratória, pressão arterial sistólica, média e diastólica saturação de oxihemoglobina, temperatura retal, pressão venosa central e fração expirada de dióxido de carbono. O tempo para adoção de decúbito esternal e posição quadrupedal também foram avaliados. Não houve diferença estatística para as variáveis cardiorrespiratórias e no tempo para adoção da posição quadrupedal. O tempo para adoção de decúbito esternal foi significativamente menor no GSEVO em relação ao GISO. Concluiu-se que a anestesia de onças pardas com detomidina/cetamina e isoflurano ou sevoflurano foi realizada de maneira segura, com estabilidade cardiorrespiratória e com aumento no tempo para adoção de decúbito esternal no GISO.

Abstract: The aim of this study was to assess the cardiopulmonary effects, the onset time after the administration of a detomidine/ketamine combination, and the recovery from anesthesia of cougars (Puma concolor) anesthetized with detomidine/ketamine and isoflurane or sevoflurane for abdominal ultrasound imaging. Fourteen animals were randomly allocated into two experimental groups: GISO (n=7) and GSEVO (n=7). Chemical restraint was performed using 0.15mg/kg detomidine combined with 5mg/kg ketamine intramuscularly; anesthesia induction was achieved using 2mg/kg propofol intravenously and maintenance with isoflurane (GISO) or sevoflurane (GSEVO). The following parameters were assessed: heart rate, respiratory rate, systolic and diastolic arterial blood pressure, mean arterial blood pressure, oxyhemoglobin saturation, rectal temperature, central venous pressure, and end-tidal carbon dioxide. The time to sternal recumbency (TSR) and time to standing position (TSP) were also determined. There was not statistically significant difference for the cardiopulmonary variables or TSP whereas TSR was significantly shorter in GSEVO. The time to onset of anesthesia was 11.1±1.2 minutes and 11.3±1.8 minutes for GISO and GSEVO, respectively. The anesthesia of cougars with detomidine/ketamine and isoflurane or sevoflurane was conducted with safety, cardiopulmonary stability, and increased time to sternal recumbency in the GISO group.

https://doi.org/10.1590/S0100-736X2016000100006 2490 downloads

15.

Produtividade de milho na presença de doses de N e de inoculação de Herbaspirillum seropedicae
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Breda, Farley Alexandre da Fonseca

; Alves, Gabriela Cavalcanti

; Reis, Veronica Massena

Pesquisa Agropecuária Brasileira

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jan 2016, Volume 51 N. 1 Pages 45 - 52

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: O objetivo deste trabalho foi avaliar o efeito de nitrogênio e da inoculação de Herbaspirillum seropedicae sobre a produtividade de milho (Zea mays) e os teores de nutrientes nos grãos. Os híbridos simples BRS 1030 e BRS 1060 receberam inoculação da estirpe BR 11417, na presença ou não de doses de adubação nitrogenada, em Argissolo Vermelho-Amarelo distrófico, durante os períodos de entressafra (plantio em maio de 2012) e safra (plantio em outubro de 2012). Em cada época, os seguintes tratamentos foram avaliados: controle absoluto, sem adubação nitrogenada nem inoculação; controle com inoculação; doses de 50 e 100 kg ha-1 de N, sem inoculação; e dose de 50 kg ha-1 de N mais inoculação. BRS 1030 produziu 1.157 kg ha-1 a mais de grãos que BRS 1060, na análise conjunta dos dois cultivos. Para o primeiro genótipo, a dose de 50 kg ha-1 de N, com inoculação, incrementou em 2% a produtividade na entressafra e em 4,5% na safra. A inoculação de H. seropedicae, estirpe BR 11417, favorece o acúmulo de P nos grãos, mas tem efeito positivo sobre a produtividade somente em combinação com doses de N mineral, o que indica que seu efeito é mais destacado na promoção do crescimento do milho do que na fixação biológica de N.

Abstract: The objective of this work was to evaluate the effect of nitrogen and inoculation with Herbaspirullum seropedicae on maize (Zea mays) yield and nutrient contents in grains. The BRS 1030 and BRS 1060 simple hybrids received inoculation with the BR 11417 strain in the presence or absence of nitrogen-fertilizer levels in a Typic Hapladult, during the periods of off-season (sowing in May 2012) and season (sowing in October 2012). In each season, the following treatments were evaluated: absolute control, without nitrogen fertilization or inoculation; inoculated control; doses of 50 and 100 kg ha-1 N, without inoculation; and dose of 50 kg ha-1 N plus inoculation. BRS 1030 produced 1,157 kg ha-1 more grains than BRS 1060, in the joint analysis of both crop seasons. For the first genotype, the dose of 50 kg ha-1 N with inoculation increased crop productivity by 2% in the off-season and by 4.5% in the season. The inoculation with H. seropedicae, BR 11417 strain, favors P accumulation in grains, but it has positive effect on yield only in combination with mineral N levels, which indicates that its effect is more important for maize growth promotion than for biological N fixation.

https://doi.org/10.1590/S0100-204X2016000100006 2543 downloads

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