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A closer look at aortic seat belt injuries: review of 52 cases published in the last 60 years
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Silva, Eduardo

; Constâncio, Vânia

; Nunes, Celso

; Baldaia, Leonor

; Castro, Miguel

; Orelhas, Luís

; Moreira, Mário

; Fonseca, Manuel

Angiologia e Cirurgia Vascular

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dec 2023, Volume 19 N. 4 Pages 221 - 225

Abstract: En | Text: En | PDF: En

Abstract Introduction: Seat belt aorta is a rare but often severe complication arising from blunt trauma with compression of the abdominal aorta against vertebrae. Seat belt sign is often present as an ecchymosis across the abdomen. The association with abdominal wall disruption and hollow viscus injury has been named seat belt triad; the presence of Chance fracture is sometimes considered a fourth component. Methods: Using Pubmed and Embase databases we reviewed all articles regarding abdominal seat belt aortic injuries and analysed presentation at admission, concomitant lesions, including presence of seat belt triad, treatment and outcomes. Results: Fifty-two cases were reported, from 1968 to 2019. Twenty-nine males (56%), mean age 43 ± 19 years. Most patients were stable at admission, with 29 (55.8%) presenting acute abdomen, 26 (50%) limb ischemia, 9 (17.3%) hypovolemic shock and 2 (3.8%) late-onset claudication. Seat belt sign was identified in 40 patients (76.9%), seat belt triad in 38 (73.1%) and 22 (42.3%) had Chance fractures, of which only 2 were not associated with seat belt triad. Most patients presented with aortic dissection (90.4%), complicated with pseudoaneurysm (11.5%), contained rupture (7.7%) or uncontained rupture (3.8%); 2 patients presented isolated iliac thrombosis and 3 limb ischemia. All patients required immediate surgical intervention, of which 40 (76.9%) required urgent vascular surgery. Forty-eight patients (92.3%) underwent vascular surgery: 39 open revascularizations and 9 endovascular procedures; three were managed conservatively. Ten patients (19.2%) passed away or died, of which 7 had seat belt triad. No patients needed reinterventions for vascular lesions except one, yet 3 required limb amputation. Most patients with seat belt triad required further visceral and abdominal wall repair. Conclusions: Seat belt aorta and especially seat belt triad are severe complications associated with high morbimortality often requiring surgery and multiple interventions. As patients are usually conscious and stable upon admission, this condition should not be disregarded.

https://doi.org/10.48750/acv.553

[SciELO Preprints] - EFFECTIVENESS OF AGA, FUKUOKA AND EUROPEAN GUIDELINES IN THE MANAGEMENT OF INCIDENTALOMAS OF THE PANCREAS ANALYZED PRIOR TO PERFORMING ENDOSCOPIC ULTRASOUND WITH FINE NEEDLE PUNCTURE
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Pacheco, Débora Azeredo de Castro Tabushi, Fernando Issamu Ardengh , José Celso Nassif, Paulo Afonso Nunes Collaço, Luiz Martins

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Publication date: 2023-12-18

Abstract: En Pt

Introduction: International consensus guidelines are commonly used to identify patients at high risk of developing cancer or with cancer. Its applicability, however, is based on investigation through imaging tests, however without histological confirmation. Objective: To compare the performance and results of international guidelines in incidental mucinous neoplasia after diagnosis obtained by endoscopic ultrasound-guided fine needle puncture (EUS-PAF). Methods: Single-center study with prospective collection of data from asymptomatic patients with the disease who underwent EUS-PAF. Appropriate cohort selection included images that were ambiguous regarding this diagnosis or the presence and/or development of other worrisome features as defined by international guidelines. After microhistological analysis of the material obtained, each of the guideline criteria was applied to identify cancer among patients with the disease. Results: 251 patients had the diagnosis confirmed by EUS-PAF or surgical procedure. The majority were asymptomatic. The final diagnosis revealed 27.8% (n=39) with malignant disease or high-risk signs. After applying the AGA-2015, IAP-2017 and DE-2018 criteria, it was observed that those detected incidentally were referred for surgery unnecessarily. These guidelines did not identify malignant and high-risk disease in 59%, 33.3% and 46.1%, respectively. Conclusion: The European DE-2018 proved to be more accurate for use in patients with asymptomatic incidental mucinous neoplasia after the diagnosis obtained by EUS-PAF.

Introdução: Consensos internacionais, são diretrizes comumente usadas para identificar pacientes com alto risco de desenvolver câncer ou com câncer. Sua aplicabilidade, entretanto, baseia-se na investigação por exames de imagem, contudo sem confirmação histológica. Objetivo: Comparar o desempenho e os resultados das diretrizes internacionais em neoplasia mucinosa incidental após diagnóstico obtido pela punção com agulha fina guiada por ultrassom endoscópico (USE-PAF). Métodos: Estudo unicêntrico com coleta prospectiva de dados de pacientes assintomáticos com a doença submetidos a USE-PAF. A seleção apropriada da coorte incluiu imagens ambíguas quanto a esse diagnóstico ou a presença e/ou desenvolvimento de outras características preocupantes, conforme definido pelas diretrizes internacionais. Após análise microhistológica do material obtido, cada um dos critérios das diretrizes foi aplicado para identificar câncer entre os pacientes com a doença. Resultados: 251 pacientes tiveram o diagnóstico confirmado pela USE-PAF ou procedimento cirúrgico. A maioria era assintomática. O diagnóstico final revelou 27,8% (n=39) com doença maligna ou sinais de alto risco.. Após aplicação dos critérios AGA-2015, IAP-2017 e DE-2018, observou-se que os detectados incidentalmente foram encaminhados para cirurgia desnecessariamente. Essas diretrizes não identificaram doença maligna e de alto risco em 59%, 33,3% e 46,1%, respectivamente às diretrizes. Conclusão: A DE-2018 europeia mostrou-se mais precisa para ser utilizada em pacientes com neoplasia mucinosa incidental assintomática após o diagnóstico obtido pela USE-PAF.

https://doi.org/10.1590/SciELOPreprints.7736

[SciELO Preprints] - PERFORMANCE OF AGA, FUKUOKA AND EUROPEAN GUIDELINES IN INCIDENTALOMAS OF THE PANCREAS SUBMITTED TO ENDOSCOPIC ULTRASOUND WITH FINE NEEDLE PUNCH
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Pacheco , Débora Azeredo de Castro Tabushi, Fernando Issamu Ardengh, José Celso Cuenca, Ronaldo Mafia Possiedi, Rafael Dib Manso, Jose Eduardo Ferreira

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Publication date: 2023-12-18

Abstract: En Pt

Introduction: Pancreatic cystic lesions are common and are not exclusively benign. There are 3 guidelines that help recommend surgery if there is a risk factor, sign of malignancy or follow the patient with imaging tests. Objective: To review and compare the performance of these guidelines in asymptomatic patients with mucinous neoplasms. Method: The literature review was carried out by collecting information published on virtual platforms in Portuguese and English. The material for reading and analysis was selected from the SciELO, Google Scholar, Pubmed and Scopus platforms. Initially, a search was carried out using the keywords “mucinous cystic neoplasm. pancreatic intraductal neoplasms. endoscopic ultrasound. fine needle aspiration” with AND or OR search, considering the title and/or abstract. Afterwards, considering only those that were most related to the topic, the full texts were read. Results: 37 articles were included. Conclusion: The European Guideline-DE-2018 proved to be more accurate for use in patients with asymptomatic mucinous neoplasia after the diagnosis obtained by EUS-PAF.

Introdução: As lesões císticas pancreáticas são comuns e não são exclusivamente benignas. Existem 3 diretrizes que ajudam a indicar cirurgia no caso de haver algum fator de risco, sinal de malignidade ou acompanhar o paciente com exames de imagem. Objetivo: Revisar e comparar o desempenho dessas diretrizes em neoplasias mucinosas identificados de forma incidental. Método: A revisão da literatura foi feita colhendo informações publicadas em plataformas virtuais em português e inglês. O material para leitura e análise foi selecionado das plataformas SciELO, Google Scholar, Pubmed e Scopus. Inicialmente foi realizada busca por descritores “neoplasia cística mucinosa. neoplasias intraductais pancreáticas. ultrassonografia endoscópica. aspiração por agulha fina” com busca AND ou OR, considerando o título e/ou resumo. Após, considerando-se somente os que tinham maior relação ao tema, foi realizada a leitura da íntegra dos textos. Resultados: Foram incluídos 37 artigos. Conclusão: A Diretriz Europeia- DE-2018 mostrou-se mais precisa para ser utilizada em pacientes com neoplasia mucinosa assintomática após o diagnóstico obtido pela USE-PAF.

https://doi.org/10.1590/SciELOPreprints.7739

Impaired flexibility in patients with tropical spastic paraparesis/HTLV-associated myelopathy: evaluation via pendulum fleximeter
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Landim, Caroline

; Dias, Cristiane Maria Carvalho Costa

; Nascimento, Celso

; Goes, Ana Lucia Barbosa

; Araújo, Thessika Hialla Almeida

; Ribeiro, Adriele

; Oliveira, Francisco Tiago de

; Castro-Lima, Humberto

; Boa-Sorte, Ney

; Galvão-Castro, Bernardo

Arquivos de Neuro-Psiquiatria

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mar 2023, Volume 81 N. 3 Pages 271 - 283

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background Flexibility is crucial to the harmonious execution of joint movements. While skeletal muscle dysfunction in patients with HTLV-1 can interfere with mobility, it is unclear whether these patients experience reduced flexibility. Objective To evaluate the differences in flexibility between HTLV-1-infected individuals with and without myelopathy compared with uninfected controls. We also investigated whether age, sex, body mass index (BMI), physical activity level, or lower back pain influence flexibility in HTLV-1-infected individuals. Methods The sample consisted of 56 adults, of which 15 did not have HTLV-1, 15 had HTLV-1 without myelopathy, and 26 had TSP/HAM. Their flexibility was assessed using the sit-and-reach test and a pendulum fleximeter. Results No differences in flexibility were observed between the groups with and without myelopathy and controls without HTLV-1 infection using the sit-and-reach test. The pendulum fleximeter results of individuals with TSP/HAM presented the lowest flexibility among the groups with respect to trunk flexion, hip flexion and extension, knee flexion, and ankle dorsiflexion, even after adjusting for age, sex, BMI, level of physical activity, and lower back pain using multiple linear regression models. Additionally, HTLV-1-infected individuals without myelopathy demonstrated reduced flexibility in movements: knee flexion, dorsiflexion, and ankle plantar flexion. Conclusions Individuals with TSP/HAM demonstrated reduced flexibility in most of the movements evaluated by the pendulum fleximeter. Additionally, HTLV-1-infected individuals without myelopathy demonstrated reduced knee and ankle flexibility, potentially representing a marker of myelopathic development.

Resumo Antecedentes A flexibilidade é fundamental para a execução harmoniosa dos movimentos articulares. Embora a disfunção do músculo esquelético em pacientes com HTLV-1 possa interferir na mobilidade, não está claro se esses pacientes apresentam flexibilidade reduzida. Objetivo Avaliar as diferenças de flexibilidade entre os indivíduos infectados com e sem mielopatia e o grupo controle sem infecção HTLV-1. Também investigamos se idade, sexo, índice de massa corporal (IMC), nível de atividade física ou dor lombar influenciam a flexibilidade em indivíduos infectados pelo HTLV-1. Métodos A amostra foi composta por 56 adultos, dos quais 15 não possuíam HTLV-1, 15 possuíam HTLV-1 sem mielopatia e 26 possuíam TSP/HAM. A flexibilidade foi avaliada por meio do teste de sentar e alcançar e do flexímetro de pêndulo. Resultados Não foram observadas diferenças na flexibilidade entre os grupos com e sem mielopatia no teste de sentar e alcançar. Os resultados do flexímetro pendular dos indivíduos com TSP/HAM apresentaram a menor flexibilidade entre os grupos em relação à flexão do tronco, flexão e extensão do quadril, flexão do joelho e dorsiflexão do tornozelo, mesmo após ajuste para idade, sexo, IMC, nível de atividade física e dor lombar usando modelos de regressão múltipla linear. Além disso, os indivíduos infectados pelo HTLV-1 sem mielopatia demonstraram redução da flexibilidade nos movimentos de flexão do joelho, dorsiflexão e flexão plantar do tornozelo. Conclusão Indivíduos com TSP/HAM demonstraram redução da flexibilidade na maioria dos movimentos avaliados pelo flexímetro pendular. Além disso, indivíduos infectados pelo HTLV-1 sem mielopatia demonstraram redução da flexibilidade do joelho e tornozelo, representando potencialmente um marcador de desenvolvimento mielopático.

https://doi.org/10.1055/s-0043-1764417

Genetic variability in pecan genotypes in Brazil
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Souza, Rafaela Schmidt de

; Martins, Carlos Roberto

; Castro, Caroline Marques

; Lima, Natércia Lobato Pinheiro

; Mello-Farias, Paulo Celso de

Revista Ceres

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2023, Volume 70 N. 5 elocation e70504

Abstract: En | Text: En | PDF: En

ABSTRACT Pecan crops has been expanding in recent years, mainly in southern Brazil. Genotypes that compose Brazilian orchards come from the USA and from selections of plants made by Brazilian producers. This study aimed to characterize with microsatellite markers pecan cultivars registered for cultivation in Brazil, including some selections made in the country. It is important to know the genetic variability of the pecan tree, as it facilitates the identification of possible phytotechnical deficiencies due to the genetic similarity between the plants, in addition to helping in the conservation of the species, among other. Thirty-four, out of forty collected accessions, were genotyped with 11 selected SSR (Simple Sequence Repeats) loci. Twenty-four polymorphic alleles were identified. The genetic similarity matrix, based on the Jaccard coefficient, ranged from 0.125 to 1.0; general mean of similarity was 0.46. The cluster analysis, which was carried out by the Unweighted Pair Group Method with Arithmetic Mean (UPGMA), classified pecan accessions into four main groups. Results showed that there is high genetic variability in germplasm evaluated, although some accessions may be duplicates.

https://doi.org/10.1590/0034-737x202370050004

Impact of Charlson Comorbidity Index adjusted to age in prognosis after endovascular abdominal aortic aneurysm repair
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Oliveira, Vânia Constâncio

; Silva, Joana Cruz

; Silva, Eduardo

; Nunes, Celso

; Castro, Miguel

; Baldaia, Leonor

; Pereira, Ricardo Vale

; Fonseca, Manuel

Angiologia e Cirurgia Vascular

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dec 2022, Volume 18 N. 4 Pages 219 - 229

Abstract: En | Text: En | PDF: En

Abstract Background: Individualized risk assessment using comorbidity adjustment is an important component in modern clinical practice and can be performed considering individual comorbidities or through the use of summary measures. The Charlson Comorbidity Index adjusted to age (CCIa) is the most widely validated and used comorbidity assessment tool. Studies have proved CCIa as a strong predictor of mortality for a variety of medical and surgical conditions; however, its utility in patients submitted to elective endovascular abdominal aortic aneurysm repair (EVAR) has not been studied. Methods: Patients submitted to EVAR between January 1, 2017 and December 31, 2021 in our tertiary, academic Vascular Surgery Department were retrospectively evaluated and 123 patients fulfilled the inclusion criteria. Patient characteristics and peri-operative variables were collected and CCIa was calculated. Surgical complications were classified according to Clavien-Dindo. The area under the curve of the receiver operating characteristic curves was calculated to validate and determine the discriminating ability of CCIa in predicting complications and mortality and the Youden index used to determine the critical value. Results: Mean age was 73.49±7.95 years and mean follow-up was 30.55±16.49 months. 30-day complication rate was 16%, 30-day mortality 1.63% and overall mortality 16%. Patients with higher CCIa had higher overall mortality (p=.002) but CCIa had no impact on 30-day complication rate and on 30-day mortality. Logistic regression showed that even after adjusting for patient´s comorbidities individually, CCIa was the only independent mortality predictor (p=.003). The optimal cutoff associated with higher overall mortality was found to be ≥6. Conclusion: CCIa does not seem to predict complications and early mortality after EVAR but it seems to be a useful predictor of mid-term survival after EVAR. These results show the limited role of this score in predicting outcomes after surgery but may help identify a sub-population whose shorter life-expectancy should be considered towards the benefits of EVAR.

https://doi.org/10.48750/acv.490

Implante de tela de polipropileno e poliglecaprone para elevação da musculatura na paralisia facial
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PITA, PEDRO CELSO DE CASTRO

; MORAIS, RAFAEL XIMENES BANDEIRA DE

; BARROS, MARCELLA FERREIRA

; CALDAS, EDUARDA AUGUSTA DE LUCENA

; ALMEIDA, CAROLINE SILVA COSTA DE

; CAVALCANTE, KYLDERY WENDELL MOURA

; SILVA, VANDERSON LAMARTINE DE LIMA

Revista Brasileira de Cirurgia Plástica

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sep 2022, Volume 37 N. 3 Pages 364 - 368

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: A paralisia facial é um quadro que pode gerar algumas sequelas, e às vezes apenas as estéticas podem ser melhoradas. Com base nisso, objetivou-se relatar um caso em que foi utilizada uma tela de polipropileno e poliglecaprone com finalidade de elevar as estruturas da hemiface direita. Relato de Caso: A paciente apresentava paralisia em hemiface direita, com selamento palpebral incompetente, desvio de comissura labial e sem movimento da musculatura temporal. Foi realizada uma incisão abaixo da costeleta, pré e retroauricular, com descolamento do retalho cutâneo em toda a hemiface direita. Após levantar o sistema musculoaponeurótico superficial e fixá-lo com fios de mononylon, foi colocada a tela de polipropileno e poliglecaprone na região do terço médio e fixada com monocryl. Foi realizada cantotomia e cantopexia lateral da pálpebra direita. No pós-operatório imediato a paciente evoluiu sem edemas, retrações ou abaulamentos, e após um ano e sete meses apresenta total integração da tela, sem retração, fibrose ou recidiva. Discussão: A escolha do tratamento estético de paralisia facial depende da causa e duração da lesão, mas existem diversas formas de fazê-lo. Entre as ideias mais novas, estão o uso de células tronco e materiais aloplásticos e, seguindo essa segunda linha, a tela de polipropileno e poliglecaprone pode ser pensada como uma técnica viável, como foi neste caso relatado.

ABSTRACT Introduction: Facial paralysis is a condition that can cause some sequelae, and sometimes only aesthetics can be improved. Based on this, the objective was to report a case in which a polypropylene and poliglecaprone mesh was used in order to raise the structures of the right hemiface. Case Report: The patient had paralysis in the right hemiface, with incompetent eyelid sealing, deviation of the labial commissure and no movement of the temporal musculature. An incision was made below the cutlet, pre and retroauricular, with detachment of the skin flap across the right hemiface. After lifting the superficial musculoaponeurotic system and fixing it with mononylon threads, the polypropylene and poliglecaprone mesh was placed in the middle third region and fixed with monocryl. Canthotomy and lateral canthopexy of the right eyelid were performed. In the immediate postoperative period, the patient evolved without edema, retraction or bulging, and after one year and seven months, she had complete integration of the mesh, with no retraction, fibrosis or recurrence. Discussion: The choice of aesthetic treatment for facial paralysis depends on the cause and duration of the injury, but there are several ways to do it. Among the newer ideas are the use of stem cells and alloplastic materials, and following this second line, the polypropylene and poliglecaprone canvas can be thought of as a viable technique, as was reported in this case.

https://doi.org/10.5935/2177-1235.2022rbcp.539-pt

Urbanização e gestão de riscos hidrológicos em São Paulo
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Castro, Afonso Celso Vanoni de

; Alvim, Angélica Tanus Benatti

Cadernos Metrópole

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aug 2022, Volume 24 N. 54 Pages 669 - 696

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Este artigo discute os riscos hidrológicos do município de São Paulo como uma construção histórica e social resultante de um planejamento da urbanização que desconsiderou as dinâmicas hidrológicas, não previu espaço para as populações vulneráveis, privilegiou a mobilidade, a expansão e a valorização fundiária. Apoia-se em fontes indiretas (leis, teses e artigos acadêmicos) e discute o Sistema Municipal de Defesa Civil à luz dos marcos vigentes e dos entes responsáveis pela gestão de riscos de desastres naturais. A gestão de riscos é tratada como questão emergencial, subordinada à Secretaria Municipal de Segurança. Com uma estrutura frágil, sem elementos básicos, desdenha seu passivo histórico e ambiental e expõe o afastamento do Estado sob a ação das políticas neoliberais.

Abstract The article discusses hydrological risks of the city of São Paulo as a historical and social construction deriving from an urbanization planning that disregarded the hydrological dynamics, did not provide space for vulnerable populations, favored mobility and urban expansion, and increased land value. It is supported by indirect sources (laws, theses, academic articles) and discusses the Municipal Civil Defense System in the light of current frameworks and entities responsible for managing risks of natural disasters. Risk management is treated as an emergency issue, subordinated to the Municipal Security Department. With a fragile structure that lacks basic elements, it disdains its historical and environmental liabilities and exposes the State’s withdrawal under the action of neoliberal policies.

https://doi.org/10.1590/2236-9996.2022-5410

Howard Becker pays a visit to our class
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Becker, Howard

; Castro, Celso

; Monnerat, Sílvia

Estudos Históricos (Rio de Janeiro)

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may 2022, Volume 35 N. 76 Pages 208 - 223

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/s2178-149420220202

10.

Reconstrução total da cobertura cutânea do pênis com retalho miocutâneo: relato de caso
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PITA, PEDRO CELSO DE CASTRO

; ALMEIDA, AMANDA COÊLHO DE ANDRADE

; ROMÃO, RICARDO FUSANO

; DELARISSA, VINÍCIUS DE OLIVEIRA PALONE

; COUTINHO, LUCAS RIBEIRO

; MORAIS, RAFAEL XIMENES BANDEIRA

Revista Brasileira de Cirurgia Plástica

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apr 2022, Volume 37 N. 2 Pages 256 - 259

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: O pênis é uma importante estrutura do corpo masculino, sendo sua reconstrução um desafio. Existem diversas doenças e deformidades que acometem este órgão, sendo necessário, em certos casos, a reconstrução total da cobertura cutânea do pênis, tendo já sido descritas na literatura diversas técnicas, tais como o uso de enxertos totais, retalho escrotal, retalhos miocutâneos da fáscia lata e outros. Relato de Caso: Neste relato é apresentada uma reconstrução da cobertura total do pênis por meio do uso de retalho miocutâneo do músculo cremaster com pele da bolsa escrotal, conseguindo prover uma boa vascularização e mantendo a permeabilidade uretral. Conclusão: Tal técnica não foi encontrada em nenhuma das bases de dados pesquisadas no trabalho, apenas semelhantes, e mostrouse como uma boa opção para a reconstrução total da cobertura cutânea peniana.

ABSTRACT Introduction: The penis is an important structure of the male body, and its reconstruction is a challenge. Several diseases and deformities affect this organ, being necessary, in certain cases, for the total reconstruction of the cutaneous coverage of the penis, having already been described in the literature several techniques, such as the use of total grafts, scrotal flap, myocutaneous flaps of the fasciae latae and others. Case Report: In this report, a reconstruction of the total coverage of the penis is presented using a myocutaneous flap of the cremaster muscle with skin from the scrotum, achieving good vascularization and maintaining urethral permeability. Conclusion: This technique was not found in any of the databases researched in this study, only similar ones, and it proved to be a good option for the total reconstruction of penile skin coverage.

https://doi.org/10.5935/2177-1235.2022rbcp0041

11.

Development and evaluation of topical formulations that contain hydroethanolic extract from Schinus terebinthifolia against HSV-1 infection
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Nocchi, Samara Requena

; Ferreira, Lilian dos Anjos Oliveira

; Castro-Hoshino, Lidiane Vizioli de

; Truiti, Maria da Conceição Torrado

; Natali, Maria Raquel Marçal

; Mello, João Carlos Palazzo de

; Baesso, Mauro Luciano

; Dias Filho, Benedito Prado

; Nakamura, Celso Vataru

; Ueda-Nakamura, Tânia

Brazilian Journal of Pharmaceutical Sciences

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2022, Volume 58 elocation e18637

Abstract: En | Text: En | PDF: En

Abstract The therapeutic drugs to treat Herpes simplex virus (HSV) infections have toxic side effects and there has been an emergence of drug-resistant strains. Therefore, the search for new treatments for HSV infections is mounting. In the present study, semi-solid formulations containing a crude hydroethanolic extract (CHE) from Schinus terebinthifolia were developed. Skin irritation, cutaneous permeation, and in vivo therapeutic efficacy of the formulations were investigated. Treatment with the ointment formulations did not result in any signs of skin irritation while the emulsions increased the thickness of the epidermis in Swiss mice. The cutaneous permeation test indicated that the CHE incorporated in the formulations permeated through the skin layers and was present in the epidermis and dermis even 3 h after topical application. In vivo antiviral activity in BALB/c mice treated with the CHE ointments was better than those treated with the CHE emulsions and did not significantly differ from an acyclovir-treated group. Taken together, this suggests that the incorporation of CHE in the ointment may be a potential candidate for the alternative topical treatment of herpetic lesions.

https://doi.org/10.1590/s2175-97902020000318637

12.

Seroprevalence of hepatitis E virus infection among volunteer blood donors in Central Brazil
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Weis-Torres, Sabrina Moreira dos Santos

; França, Adriana de Oliveira

; Granato, Celso

; Passarini, Amanda

; Motta-Castro, Ana Rita Coimbra

Brazilian Journal of Infectious Diseases

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2022, Volume 26 N. 2 elocation 102350

Abstract: En | Text: En | PDF: En

Abstract A cross-sectional study was carried out in the Hematology and Hemotherapy Institute of the state of Mato Grosso do Sul (Hemosul) to evaluate the seroprevalence and risk factors of Hepatitis E Virus (HEV) exposure among volunteer blood donors in Central Brazil. Two-hundred fifty samples from the biorepository were tested for anti-HEV IgG and IgM using the Wantai HEV ELISA test. The seroprevalence of HEV exposure was 6.4% (95% CI: 3.9–10.2). Being born in another state of Brazil, mainly in the Southeast and South regions, was associated with a higher risk of HEV exposure (p < 0.001).

https://doi.org/10.1016/j.bjid.2022.102350

13.

Associação da Composição Corporal com Rigidez Arterial em Longevos
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Melo e Silva, Flávia Veríssimo

; Almonfrey, Franciellen Bruschi

; Freitas, Cinthia Medice Nishide de

; Fonte, Flávia Kurebayashi

; Sepulvida, Mariana Bellaguarda de Castro

; Almada-Filho, Clineu de Mello

; Cendoroglo, Maysa Seabra

; Quadrado, Egli Belinazzi

; Amodeo, Celso

; Povoa, Rui

; Miranda, Roberto Dischinger

Arquivos Brasileiros de Cardiologia

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sep 2021, Volume 117 N. 3 Pages 457 - 462

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento Pouco se conhece sobre a relação entre sarcopenia e hemodinâmica central em idosos longevos. Objetivo Estudar a relação da rigidez arterial com a composição corporal em idosos longevos. Métodos A composição corporal foi avaliada por meio da absortometria de Raio X de dupla energia (DEXA) e dos parâmetros de circulação central (PCC) obtidos por método oscilométrico não invasivo, com o Mobil-O-Graph 24h PWA Monitor®. Os parâmetros centrais avaliados foram: velocidade da onda de pulso (VOP), augmentation index (AIx), índice de amplificação da pressão de pulso (iAPP) e pressão de pulso central (PPc). Estes foram correlacionados com massa magra total (MM) e apendicular (MA), percentual de gordura corporal e índice de Baumgartner (IB). Aceitou-se nível de significância de 5%. Resultados Participaram 124 longevos, com idade média de 87,1 anos (DP±4,3 anos), sendo 74,2% mulheres e 57,3% brancos. Houve correlação inversa do AIx com as variáveis MM (r = - 0,391, p < 0,001), MA (r= -0,378, p< 0,001) e IB (r = -0,258, p 0,004). A PPc apresentou associação inversa com MM (r= -0,268, p =0,003), MA (r=-0,288, p= 0,001) e IB (r= -0,265, p = 0,003). Houve relação direta apenas entre AIx e percentual de gordura corporal (r= 0,197, p= 0,029). Conclusão Em idosos longevos, o percentual de gordura corporal se associa diretamente com a rigidez arterial e tem associação inversa com a quantidade de MM. Esses achados podem estar associados ao maior risco cardiovascular.

Abstract Background Arterial stiffness, obesity and sarcopenia correlate with each other and with cardiac outcomes in younger adults. However, there is little evidence of the association between body composition and markers of central arteries stiffness in long-lived people. Objective To evaluate the relationship between arterial stiffness and body composition in functionally independent long-lived individuals. Methods This is a cross-sectional analysis of the association between markers of arterial stiffness and body composition among participants in a longitudinal cohort of elderly individuals aged 80 years or older who were functionally independent and lived in the community . Body composition measurements were performed using dual energy X-ray absorptiometry (DEXA) and central circulation parameters (CCP) obtained by a non-invasive oscillometric method through the Mobil-O-Graph 24h PWA Monitor® device. The central parameters evaluated were: pulse wave velocity (PWV), augmentation Index (AIx), pulse pressure amplification index (PPAi) and central pulse pressure (cPP). These were correlated to total lean mass (LM) and appendicular lean mass (aLM), body fat percentage, and Baumgartner’s Index (BI). The level of significance was set at 5% for all tests. Results Data from 124 elderly people with a mean age of 87.1 years (SD ± 4.3 years) were analyzed, with 74.2% of women and 57.3% of white. There was a statistically significant inverse correlation of AIx with LM (r = -0.391, p <0.001), aLM (r = -0.378, p <0.001), and BI (r = -0.258, p = 0.004). Also, cPP had an inversely proportional association with LM (r = -0.268, p = 0.003), aLM (r = -0.288, p = 0.001), and BI (r = -0.265, p = 0.003). When assessing the relationship between fat mass and CCP, a statistically significant direct relationship was observed only between AIx and body fat percentage (r = 0.197, p = 0.029). Conclusion In long-lived people, body fat percentage is directly associated with arterial stiffness and inversely associated with the amount of LM. These findings may be associated with increased cardiovascular risk.

https://doi.org/10.36660/abc.20190774 225 downloads

14.

Consensus statement for diagnosis and treatment of paroxysmal nocturnal haemoglobinuria
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Cançado, Rodolfo D

; Araújo, Aderson da Silva

; Sandes, Alex Freire

; Arrais, Celso

; Lobo, Clarisse Lopes de Castro

; Figueiredo, Maria Stella

; Gualandro, Sandra Fátima Menosi

; Saad, Sara Teresinha Olalla

; Costa, Fernando Ferreira

Hematology, Transfusion and Cell Therapy

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sep 2021, Volume 43 N. 3 Pages 341 - 348

Abstract: En | Text: En | PDF: En

Paroxysmal nocturnal hemoglobinuria is a chronic, multi-systemic, progressive and lifethreatening disease characterized by intravascular hemolysis, thrombotic events, serious infections and bone marrow failure. Paroxysmal nocturnal hemoglobinuria results from the expansion of a clone of hematopoietic cells that due to an inactivating mutation of the X-linked gene PIG-A are deficient in glycosylphosphatidylinositol-linked proteins. Early diagnosis, using flow cytometry performed on peripheral blood, the gold standard test to confirm the diagnosis of paroxysmal nocturnal hemoglobinuria, is essential for improved patient management and prognosis. The traditional therapy for paroxysmal nocturnal hemoglobinuria includes blood transfusion, anti-thrombosis prophylaxis or allogeneic bone marrow transplantation. The treatment that has recently become available is the complement blockade by the anti-C5 monoclonal antibody eculizumab. In this consensus, we are aiming to review the diagnosis and treatment of the paroxysmal nocturnal hemoglobinuria patients, as well as the early recognition of its systemic complications. These procedures express the opinions of experts and have been based on the best available evidence and international guidelines, with the purpose of increasing benefits and reducing harm to patients.

https://doi.org/10.1016/j.htct.2020.06.006 23 downloads

15.

Posicionamento sobre Diagnóstico e Tratamento da Amiloidose Cardíaca – 2021
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Simões, Marcus V.

; Fernandes, Fabio

; Marcondes-Braga, Fabiana G.

; Scheinberg, Philip

; Correia, Edileide de Barros

; Rohde, Luis Eduardo P.

; Bacal, Fernando

; Alves, Silvia Marinho Martins

; Mangini, Sandrigo

; Biolo, Andréia

; Beck-da-Silva, Luis

; Szor, Roberta Shcolnik

; Marques Junior, Wilson

; Oliveira, Acary Souza Bulle

; Cruz, Márcia Waddington

; Bueno, Bruno Vaz Kerges

; Hajjar, Ludhmila Abrahão

; Issa, Aurora Felice Castro

; Ramires, Felix José Alvarez

; Coelho Filho, Otavio Rizzi

; Schmidt, André

; Pinto, Ibraim Masciarelli Francisco

; Rochitte, Carlos Eduardo

; Valicelli, Flávio Henrique

; Vieira, Marcelo Luiz Campos

; Mesquita, Cláudio Tinoco

; Ramos, Celso Dario

; Soares-Junior, José

; Romano, Minna Moreira Dias

; Mathias Junior, Wilson

; Garcia Junior, Marcelo Iório

; Montera, Marcelo Westerlund

; Melo, Marcelo Dantas Tavares de

; Silva, Sandra Marques e

; Garibaldi, Pedro Manoel Marques

; Alencar Neto, Aristóteles Comte de

; Lopes, Renato Delascio

; Ávila, Diane Xavier de

; Viana, Denizar

; Saraiva, José Francisco Kerr

; Canesin, Manoel Fernandes

; Oliveira, Glaucia Maria Moraes de

; Mesquita, Evandro Tinoco

Arquivos Brasileiros de Cardiologia

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sep 2021, Volume 117 N. 3 Pages 561 - 598

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210718 330 downloads

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