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Abstract Background: The relationship between viral infections and host factors holds high hopes for identifying the role of Interferon Lambda 3 (IFNL3) and Interleukin 6 (IL-6) polymorphisms in the development of Chronic Liver Disease (CLD) in patients infected with hepatitis Delta virus (HDV) in the Western Brazilian Amazon. Methods: Cross-sectional study conducted with a cohort of 40 chronic HDV patients, 27 with CLD and 13 without evident liver damage. Biological samples from the participants were analyzed using the polymerase chain reaction (PCR) technique, followed by sequencing by the automated Sanger method. Results: The rs8099917 T allele, from the IFNL3 gene, showed a higher frequency in both groups; however, it was not possible to establish an association with HDV infection [OR = 1.42 (0.42 - 4.75; p = 0.556 (95% CI). For IL-6, the rs1800795 G allele was superior to rs1800795 C. Analyzing both distributions in the studied groups, any association with HDV was absent (p > 0.05). Conclusion: The results suggest that the rs8099917 T/G (IFNL3) and rs1800795 G/C (IL-6) polymorphisms are not associated with the evolution of HDV in the studied population.

https://doi.org/10.1590/1678-9199-jvatitd-2023-0025

The Zebrafish as an Alternative Animal Model for Ecotoxicological Research and Testing
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Braga, Ana Paula Andrade

; Souza, Leticia Rosa de

; Lima, Maria Gabriela Franco

; Cruz, Jaqueline Matos

; Souza, Ana Cristina Zullo de

; Costa, Mariana Santos

; Castro, Vera Lucia Scherholz Salgado de

; Marin-Morales, Maria Aparecida

Brazilian Archives of Biology and Technology

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2024, Volume 67 elocation e24220968

Abstract: En | Text: En | PDF: En

Abstract Anthropogenic interventions have had a compromising effect on environmental health, intensifying the degradation of ecosystems, and the quantity of chemical pollutants released into nature. Therefore, research areas within the scope of environmental assessments and monitoring such as ecotoxicology have contributed to the determination of the toxic potential of contaminants. A small cyprinid known as the zebrafish (Danio rerio), the use of which has exponentially grown, is an alternative vertebrate model for scientific research, mainly in the assessment of environmental risks. The species exhibits several advantages for breeding in a laboratory, in addition to presenting multi-biomarkers of environmental toxicity. Thus, this review aims to present the main characteristics and advantages of working with this species, as well as show studies related to ecotoxicology involving biomarkers of toxicity in zebrafish. The results show a progressive trend towards employing the species in environmental risk analyses, it is an increasingly recommended species in the assessment of the toxicity level of a range of chemical pollutants. The development of future technologies must contribute to scientific advancement, rendering the potential application of this model organism an even more widespread one, which will certainly help in bridging knowledge gaps in various areas of study.

https://doi.org/10.1590/1678-4324-2024220968

Cognitive assessment in preterms by Bayley-III: development in the first year and associated factors
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Oliveira, Suelen Rosa de

; Machado, Ana Carolina Cabral de Paula

; Magalhães, Lívia de Castro

; Miranda, Débora Marques de

; Paula, Jonas Jardim de

; Bouzada, Maria Cândida Ferrrez

Revista Paulista de Pediatria

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2024, Volume 42 elocation e2022164

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: To analyze the cognitive development of preterm infants at six and 12 months of corrected age and the associations with perinatal and socioeconomic factors. Methods: Cognitive development of 40 infants (20 preterm and 20 full-term) at six and 12 months of age was evaluated using the Bayley-III scale. Correlations between cognitive outcome and associated factors were assessed using Spearman correlation. Stepwise multiple linear regression analysis with covariance was applied to identify changes on cognitive score between six and 12 months. Results: Bayley-III cognitive score in preterm group was significantly lower than in full-term group at both six and 12 months of age. Birth weight correlated with cognitive performance at six months and head circumference at birth at 12 months, in full-terms infants. The occurrence of necrotizing enterocolitis was inversely associated with cognitive score in preterms at 12 months. An increase in cognitive score was observed between six and 12 months in both groups, but the gain was more pronounced in preterms. Conclusions: These findings suggest some cognitive recovery capacity in the first year despite the restrictions imposed by premature birth and emphasize the importance of early interventions in this population.

RESUMO Objetivo: Avaliar o desenvolvimento cognitivo de crianças pré-termo aos seis e 12 meses de idade corrigida e as associações com fatores perinatais e socioeconômicos. Métodos: O desenvolvimento cognitivo de 40 crianças (20 pré-termo e 20 a termo) foi avaliado aos seis e 12 meses de idade, utilizando a escala Bayley-III. Correlações entre resultados cognitivos e fatores associados foram avaliadas pelo teste de correlação de Spearman. A análise de regressão linear múltipla stepwise com covariância foi aplicada para identificar mudanças na pontuação cognitiva entre seis e 12 meses. Resultados: O escore cognitivo no grupo pré-termo foi significativamente menor que no grupo a termo aos seis e 12 meses. O peso ao nascer foi diretamente associado com o desempenho cognitivo aos seis meses e perímetro cefálico ao nascimento aos 12 meses, nas crianças a termo. A ocorrência de enterocolite necrosante foi inversamente associada ao desempenho cognitivo em pré-termos, aos 12 meses. Verificou-se aumento na pontuação cognitiva entre seis e 12 meses nos dois grupos, porém mais pronunciado no pré-termo. Conclusões: O estudo sugere que crianças pré-termo apresentam alguma capacidade de recuperação cognitiva no primeiro ano, apesar das restrições impostas pelo nascimento prematuro, e enfatizam a importância de acompanhamento dessa população desde os primeiros meses de vida.

https://doi.org/10.1590/1984-0462/2024/42/2022164

Medicina Familiar en Guantánamo: historia, logros y desafíos
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Jiménez de Castro Morgado, María Inés

; de la Cruz Carmenaty, Yuleisi

; Sánchez Figueredo, Ana Margarita

Revista Información Científica

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2024, Volume 103 elocation e4505

Abstract: Es | Text: Es | PDF: Es

Posicionamento do Departamento de Imagem Cardiovascular da Sociedade Brasileira de Cardiologia sobre o Uso do Strain Miocárdico na Rotina do Cardiologista – 2023
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Almeida, André Luiz Cerqueira

; Melo, Marcelo Dantas Tavares de

; Bihan, David Costa de Souza Le

; Vieira, Marcelo Luiz Campos

; Pena, José Luiz Barros

; Del Castillo, José Maria

; Abensur, Henry

; Hortegal, Renato de Aguiar

; Otto, Maria Estefania Bosco

; Piveta, Rafael Bonafim

; Dantas, Maria Rosa

; Assef, Jorge Eduardo

; Beck, Adenalva Lima de Souza

; Santo, Thais Harada Campos Espirito

; Silva, Tonnison de Oliveira

; Salemi, Vera Maria Cury

; Rocon, Camila

; Lima, Márcio Silva Miguel

; Barberato, Silvio Henrique

; Rodrigues, Ana Clara

; Rabschkowisky, Arnaldo

; Frota, Daniela do Carmo Rassi

; Gripp, Eliza de Almeida

; Barretto, Rodrigo Bellio de Mattos

; Silva, Sandra Marques e

; Cauduro, Sanderson Antonio

; Pinheiro, Aurélio Carvalho

; Araujo, Salustiano Pereira de

; Tressino, Cintia Galhardo

; Silva, Carlos Eduardo Suaide

; Monaco, Claudia Gianini

; Paiva, Marcelo Goulart

; Fisher, Cláudio Henrique

; Alves, Marco Stephan Lofrano

; Grau, Cláudia R. Pinheiro de Castro

; Santos, Maria Veronica Camara dos

; Guimarães, Isabel Cristina Britto

; Morhy, Samira Saady

; Leal, Gabriela Nunes

; Soares, Andressa Mussi

; Cruz, Cecilia Beatriz Bittencourt Viana

; Guimarães Filho, Fabio Villaça

; Assunção, Bruna Morhy Borges Leal

; Fernandes, Rafael Modesto

; Saraiva, Roberto Magalhães

; Tsutsui, Jeane Mike

; Soares, Fábio Luis de Jesus

; Falcão, Sandra Nívea dos Reis Saraiva

; Hotta, Viviane Tiemi

; Armstrong, Anderson da Costa

; Hygidio, Daniel de Andrade

; Miglioranza, Marcelo Haertel

; Camarozano, Ana Cristina

; Lopes, Marly Maria Uellendahl

; Cerci, Rodrigo Julio

; Siqueira, Maria Eduarda Menezes de

; Torreão, Jorge Andion

; Rochitte, Carlos Eduardo

; Felix, Alex

Arquivos Brasileiros de Cardiologia

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dec 2023, Volume 120 N. 12 elocation e20230646

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20230646

Hipopotasemia no medicamentosa como biomarcador de nefropatía crónica temprana en adultos del sur de Honduras
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Linarez Ochoa, Nery Erasmo

; Claros Rivas, Ricardo Javier

; Coello Espinal, Lorena Patricia

; Castro Rodríguez, Gustavo Adolfo

; Silva Andino, Sandra Marcela

; Ventura Díaz, Ana Cristina

; Rodríguez Mendoza, José Gaspar

; Durón, Reyna María

Revista Cubana de Medicina

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dec 2023, Volume 62 N. 4 elocation e3283

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Introduction: Hypokalemia is a frequent hydroelectrolytic disorder, associated with systemic and multifactorial diseases, whose acute form can be complicated and cause death, but in its chronic presentation it can be a marker of nephropathy. Objective: To characterize the profile of the patient with non-drug hypokalemia seen in an emergency. Methods: The records of patients older than 18 years diagnosed with hypokalemia, admitted to the hospital from June 2018 to December 2019, were reviewed. Demographic data, medical history, and post-treatment evolution were collected. It was compared with 108 patients without hypokalemia seen in the same period. Results: 87 cases with mean age of 38.5 years were studied. 90.8% were men under 50 years of age, who worked as farmers (29.9%), with history of exposure to pesticides and high ambient temperatures. Most of them had no history of previous cardiometabolic or renal disease. 48.3% of all patients with hypokalemia (n = 42) had creatinine higher than 1.2 mg/dL and 63% had hyponatremia. Hypokalemia was moderate in 39% and severe in 12%, and it was found that men were affected 4.7 times more than women. Regarding the group without hypokalemia and abnormal creatinine, they had higher frequency of chronic disease (92.5% versus 8%). Conclusions: Non-drug hypokalemia was found in male farmers, without chronic disease, but with evidence of early nephropathy and hyponatremia. The possibility of Mesoamerican nephropathy was suggested. A regional epidemiological alert and a prevention and control program should be established.

RESUMEN Introducción: La hipopotasemia es un trastorno hidroelectrolítico frecuente, asociado a enfermedades sistémicas y multifactoriales, cuya forma aguda puede complicarse y causar la muerte, pero en su presentación crónica puede ser un marcador de nefropatía. Objetivo: Caracterizar el perfil del paciente con hipopotasemia no medicamentosa atendidos de emergencia. Métodos: Se revisaron los registros de pacientes mayores de 18 años con diagnóstico de hipopotasemia, ingresados en el hospital en el período de junio 2018 a diciembre de 2019. Se colectaron datos demográficos, antecedentes médicos y evolución postratamiento. Se comparó con 108 pacientes sin hipopotasemia atendidos en el período de estudio. Resultados: Se encontraron 87 casos con edad media de 38,5 años. El 90,8 % eran hombres menores de 50 años, de oficio agricultor (29,9 %), con historia de exposición a plaguicidas y a altas temperaturas ambientales. La mayoría de ellos no tenía historia de enfermedad cardiometabólicas o renal previa. El 48,3 % de todos los pacientes con hipopotasemia (n = 42) tenía creatinina mayor a 1,2 mg/dL y 63 % tenía hiponatremia. La hipopotasemia fue moderada en 39 % y severa en 12 %, los hombres 4,7 veces más afectados que las mujeres. Respecto al grupo sin hipopotasemia y creatinina anormal, tenían mayor frecuencia de enfermedad crónica (92,5 % versus 8 %). Conclusiones: Se encontró hipopotasemia no medicamentosa en varones agricultores, sin enfermedad crónica, pero con datos de nefropatía temprana e hiponatremia, se sugirió la posibilidad de nefropatía mesoamericana. Debe establecerse una alerta epidemiológica regional y un programa de prevención y control.

Escala para determinar intervalo de avaliação dos acessos periféricos em pediatria: Estudo convergente assistencial
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Santos, Maria Lucia Barbosa Maia dos

; Castro, Amparito del Rocío Vintimilla

; Almeida, Ana Paula

; Fraga, Ana Paula Maia

; Costa, Andrea Aoki

Revista de Enfermagem Referência

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dec 2023, Volume serVI N. 2 elocation e30864

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

Marco contextual: Según la bibliografía, entre el 58,7% y el 86,7% de los pacientes hospitalizados tienen un catéter venoso periférico. Sin embargo, el uso de este dispositivo no está exento de complicaciones. La gestión de estos dispositivos genera una importante necesidad de cuidados por parte del equipo de enfermería. Objetivo: Construir y validar una escala para determinar el intervalo de tiempo para evaluar los accesos periféricos mediante infusión continua en pediatría. Metodología: Estudio metodológico, observacional, prospectivo, cuantitativo y convergente asistencial. Resultados: La escala se sometió a dos fases de validación de constructo. La suma final de todas las puntuaciones mostró una concordancia del 87,5%. La prueba de fiabilidad Kappa lineal ponderada indicó una fiabilidad casi perfecta de 0,91, 0,87 y 0,88 para el estado clínico del paciente, las características de las venas y la puntuación final, respectivamente. Todos los indicadores fueron estadísticamente significativos (p = 0,001). Conclusión: El intervalo de tiempo para evaluar los accesos periféricos en infusión continua, teniendo en cuenta la especificidad de cada paciente, es posible utilizando la Escala de Maia y Castro, que ayuda a la práctica de los cuidados de enfermería en la población pediátrica.

Resumo Enquadramento: Segundo a literatura 58,7% a 86,7% dos pacientes hospitalizados têm um cateter venoso periférico. Contudo, a utilização desse dispositivo não é isenta de complicações. A gestão desses dispositivos gera uma necessidade significativa de cuidados pela equipa de enfermagem. Objetivo: Construir e validar uma escala para determinar o intervalo tempo para a avaliação dos acessos periféricos em uso de infusão contínua em pediatria. Metodologia: Estudo, metodológico, observacional, prospetivo, quantitativo e convergente assistencial. Resultados: A escala foi submetida a duas fases para validação de constructo. A somatória final de todos os scores teve concordância de 87,5%. O Teste de confiabilidade de Kappa Ponderado Linear apontou confiabilidade quase perfeita 0,91, 0,87 e 0,88 para a condição clínica do paciente, características das veias e a pontuação final, respetivamente. Todos os indicadores foram estatisticamente significativos (p = 0,001). Conclusão: O intervalo de tempo para avaliação dos acessos periféricos em infusão contínua considerando a especificidade de cada paciente é possível utilizando a Escala Maia e Castro que auxilia a prática da assistência do enfermeiro na população pediátrica.

Abstract Background: According to the literature 58.7% to 86.7% of hospitalized patients have a peripheral venous catheter. However, the use of this device is not without complications. The management of these devices generates a significant demand for care by the nursing team. Objective: Construct and validate a scale to determine the time interval for the evaluation of peripheral accesses using continuous infusion in pediatrics. Methodology: Methodological, observational, prospective, quantitative and convergent assistential study. Results: The scale was submitted to two phases for construct validation. The final sum of all scores had an agreement of 87.5%. The Linear Weighted Kappa Reliability Test showed almost perfect reliability 0.91, 0.87 and 0.88 for patient’s clinical condition, vein characteristics and final score respectively. All indicators were statistically significant (p = 0.001). Conclusion: The time interval for the evaluation of peripheral accesses in continuous infusion, considering the specificity of each patient, is possible using the Maia e Castro scale, which helps the practice of nursing care in pediatric patients.

https://doi.org/10.12707/rvi23.54.30864

Testamento vital: uma ferramenta para fim de vida em todas as fases da vida
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Pires, João R. Nunes

; Guimarães, Mariana Castro

; Alves, Ana Maria

; Garuta, Ina

; Leite, Raquel Baptista

Revista Portuguesa de Medicina Geral e Familiar

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oct 2023, Volume 39 N. 5 Pages 488 - 490

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.32385/rpmgf.v39i5.13874

10.

Alta responsável e relações interprofissionais na perspectiva e no agir da enfermagem em tempos de pandemia de COVID-19
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Andreazza, Rosemarie

; Chioro, Arthur

; Bragagnolo, Larissa Maria

; Silva, Franciele Finfa da

; Pereira, Ana Lucia

; Mauri, Leonardo

; Rodrigues, Elen Paula

; Furtado, Lumena Almeida de Castro

; Carapinheiro, Graça

Ciência & Saúde Coletiva

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oct 2023, Volume 28 N. 10 Pages 3023 - 3032

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Com o objetivo de analisar as relações interprofissionais produzidas a partir da alta responsável, na perspectiva e no agir da enfermagem durante o a pandemia de COVID-19, realizou-se um estudo qualitativo, tipo estudo de caso. A técnica de pesquisa foi a observação participante de uma enfermaria de hospital de grande porte do SUS na cidade de São Paulo. A produção de narrativas e a análise micropolítica das relações fez emergir dois planos de visibilidade: para além da alta responsável - a antropofagia dos arranjos tecnológicos do cuidado e a ambivalência da enfermagem na produção das relações interprofissionais; e alta médico-centrada e alta negociada - o entrecruzamento com outros profissionais, com as famílias e com a vida “como ela é”. A pandemia de COVID interrompeu as visitas multiprofissionais e foi um analisador das relações interprofissionais. A partir de uma inteligência astuciosa, a enfermagem negocia a alta com os médicos, que detêm este poder, e aciona a equipe, a partir de uma autonomia elástica. A alta responsável por si só não foi capaz de produzir um plano comum de ação interprofissional, de modificar os papéis instituídos no hospital, situação que recrudesceu durante a pandemia mas abriu condições para o aumento da profissionalização da equipe.

Abstract A qualitative-case study was carried out aimed at analyzing the interprofessional relationships generated by the planned discharge from the nursing actions’ perspective during the COVID-19 pandemic. The study method was the participating observation by one nurse who works in a large SUS hospital in the city of São Paulo. The production of narratives and the micropolitics analysis resulted in two diverse visibility plans: beyond the planned discharge the anthropophagy of the technological arrangements for care and the ambivalence of the nursing staff in the production of interprofessional relationships; and the medical discharge and negotiated discharge: the intersecting with other professionals, with the families and with “real” life. The pandemic interrupted the multiprofessional visits and it was an analyzer of the interprofessional relationships. Wittingly, the nursing staff negotiates the discharges with physicians, who retain this power, and sets the team in motion using an elastic autonomy. The planned discharge alone was not able to guarantee a common interprofessional action plan, was not able to modify the constituted roles in the hospital, a situation that increased during the pandemic, but allowed the right setting aimed to increase the team’s professionalism.

https://doi.org/10.1590/1413-812320232810.11092023

11.

Alta responsável e relações interprofissionais na perspectiva e no agir da enfermagem em tempos de pandemia de COVID-19
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Andreazza, Rosemarie

; Chioro, Arthur

; Bragagnolo, Larissa Maria

; Silva, Franciele Finfa da

; Pereira, Ana Lucia

; Mauri, Leonardo

; Rodrigues, Elen Paula

; Furtado, Lumena Almeida de Castro

; Carapinheiro, Graça

Ciência & Saúde Coletiva

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oct 2023, Volume 28 N. 10 Pages 3023 - 3032

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/1413-812320232810.11092023

12.

Mortalidad de pacientes hospitalizados por Covid-19 en México, revisión sistemática
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Portocarrero Granados, Ana

; Castro Rodríguez, Lya Angélica

; Sandoval Cabrera, Antonio

; Romero Figueroa, María del Socorro

Revista de la Facultad de Medicina Humana

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oct 2023, Volume 23 N. 4 Pages 142 - 149

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Introduction: Since the start of the pandemic, Mexico was one of the countries with the highest mortality rates from COVID 19. Objective: To determine if type 2 diabetes mellitus, arterial hypertension, and obesity increase mortality in patients diagnosed with COVID-19 who required hospitalization in Mexico. Methods: Systematic review in Pubmed MeSH, Web of Science, Lilas, Scielo, and Google Scholar with the terms MeSH COVID-19, SARS-COV2, Coronavirus, and Mexico for the years 2020 and 2021, in English or Spanish. Two reviewers selected the studies, two additional reviewers participated in the analysis of the studies. Results: Seventy three studies carried out in Mexico from 2020 to 2021 were included with information obtained from the databases of the National Epidemiological Surveillance System of Mexico. With an average age of 52.9 ± 13.27 years, 64% of the included patients were women, in general, a mortality rate of 16.76% (Min-Max 0.77-73.73%) was reported. 71% of the studies (52) did not report specific mortality related to comorbidities the most prevalent pathology was obesity with 24.23% (Min-Max 11.50-71.00%), followed by arterial hypertension 22.23% (Min-Max 2.0-53.96%) and finally Diabetes mellitus with 18.10% (Min-Max 1.83-40.00%). Conclusion: The most common comorbidity among patients hospitalized for COVID in Mexico was obesity, followed by type 2 diabetes mellitus and hypertension.

RESUMEN Introducción: Desde el inicio de la pandemia, México fue de los países que presentó tasas de mortalidad más altas por COVID 19. Objetivo: Determinar si la diabetes mellitus tipo 2, la hipertensión arterial y la obesidad incrementan la tasa de mortalidad en pacientes con diagnóstico de COVID-19 que requirieron hospitalización en México. Métodos: Revisión sistemática en Pubmed MeSH, Web of Science, Lilas, Scielo y Google Scholar con los términos MeSH “COVID-19”, “SARS-COV2”, “Coronavirus”, y “México” durante los años 2020 y 2021, incluyendo artículos en inglés y español. Para el proceso de selección de artículos, dos revisores seleccionaron los estudios mientras que otros dos revisores adicionales participaron en el análisis de dichos estudios. Resultados: Se incluyeron 73 estudios realizados en México del 2020 al 2021 con información obtenida a través de las bases de datos del Sistema Nacional de Vigilancia Epidemiológica de México. Se incluyeron pacientes con un promedio de edad de 52,9 años ±13,27, el 64% de los pacientes incluidos fueron mujeres, se reportó una tasa de mortalidad de 6.76% (Min-Max 0.77-73.73%). El 71% de los estudios (52), no reportaron la mortalidad específica relacionada con las comorbilidades. La patología más prevalente fue la obesidad con un 24.23% (Min-Max 11.50-71.00%), seguida de la hipertensión arterial con un 22.23% (Min-Max 2.0-53.96%) y finalmente la diabetes mellitus tipo 2 con un 18.10% (Min-Max 1.83-40.00%). Conclusión: La comorbilidad más común entre los pacientes hospitalizados por COVID 19 en México fue la obesidad, seguida de la diabetes mellitus tipo 2 y por último la hipertensión.

https://doi.org/10.25176/rfmh.v23i4.5877

13.

Nutritional characterization, antioxidant activity and bergenin content of the pulp of Endopleura uchi
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OLIVEIRA, Régis Tribuzy de

; CASTRO, Lorena Mota de

; NASCIMENTO, Whendel Mesquita do

; GOMES, Maria Letícia de Sousa

; OLIVEIRA, Roseane Pinto Martins de

; LOBATO, Ana Cecilia Nina

; NUNOMURA, Rita de Cássia Saraiva

; PEREIRA, Carlos Victor Lamarão

; ZANOTTO, Sandra Patrícia

Acta Amazonica

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sep 2023, Volume 53 N. 3 Pages 254 - 263

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT The yellow uxi (Endopleura uchi) is a tree native to the Amazon and its fruits are appreciated in the region. It is rich in total phenols and its bark is known to have high bergenin content, an isocoumarin derivative that presents several pharmacological activities. Yet the nutritional and functional properties of the fruit are still little known. We analyzed the nutritional, centesimal, and mineral properties, and the antioxidant activity and total phenol content of the alcoholic extract of yellow uxi fruit pulp from different locations in the Amazon. The bergenin content was also quantified. Average pulp yield was 45.66 ± 4.44% (w/w), with 60.1 - 89.2 g 100 g-1 of moisture and 1.28 - 1.32 g 100 g-1 of ash (dry basis). Calcium (78.2 - 87.1 mg 100 g-1) and potassium (260.2 - 395 mg 100 g-1) were the most abundant minerals in the pulp. Aluminum concentration was high compared to other Amazonian fruits (23.7 - 28.7 mg 100 g-1). The high caloric value of the pulp (325.3 ± 20.9 Kcal 100 g-1) is attributed to its lipid (32 - 44.9%) and carbohydrate (48.2 - 64.1%) content. The scavenging activity of DPPH was 1.95 - 20.68%, which was highly associated with the total phenolic content (16.91 - 30.07 µg GAE mg-1). Bergenin content was 180.8 ± 55.3 mg 100 g-1. We conclude that E. uchi pulp has high caloric and mineral content, and it is also a source of bergenin, thus this fruit has a potential nutritional and functional value.

RESUMO O uxi amarelo (Endopleura uchi) é uma árvore nativa da região amazônica e suas frutas são apreciadas na região. Ele é rico em fenóis e sua casca tem alto teor de bergenina, um derivado da isocumarina conhecido por apresentar diversas atividades farmacológicas. No entanto, as propriedades nutricionais e funcionais do fruto ainda são pouco conhecidas. Nós analisamos as propriedades nutricionais, centesimais e minerais, e a atividade antioxidante e o teor de fenólicos do extrato alcoólico da polpa do fruto do uxi amarelo de diferentes localidades da Amazônia. O teor de bergenina também foi quantificado. O rendimento médio de polpa foi de 45,66 ± 4,44% (m/m), com 60,1 - 89,2 g 100 g-1 de umidade e 1,28 - 1,32 g 100 g-1 de cinzas (base seca). Cálcio (78,2 - 87,1 mg 100 g-1) e potássio (260,2 - 395 mg 100 g-1) foram os minerais mais abundantes na polpa. A concentração de alumínio foi alta em comparação com outras frutas amazônicas (23,7 - 28,7 mg 100 g-1). O alto valor calórico da polpa (325,3 ± 20,9 Kcal 100 g-1) é atribuído ao seu teor de lipídios (32 - 44,9%) e carboidratos (48,2 - 64,1%). A atividade sequestradora do DPPH foi de 1,95 - 20,68%, altamente associada ao teor de fenólicos totais (16,91 - 30,07 µg GAE mg-1). A quantidade de bergenina na polpa foi de 180,8 ± 55,3 mg 100 g-1. Concluímos que a polpa de E. uchi possui alto teor calórico e mineral, além de ser fonte de bergenina, portanto, este fruto possui valor nutricional e funcional potencial.

https://doi.org/10.1590/1809-4392202202462

14.

Impact of Telemedicine use on clinical care indicators of pediatric intensive care units: protocol for a cluster randomized clinical trial
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Silva, Mariana Motta Dias da

; Klever, Emanuele König

; Rocha, Jacqueline Castro da

; Silva, Gabriela de Oliveira Laguna

; Amorim, Jerusa da Rocha de

; Dode, Andressa Dutra

; Simionato, Bárbara Marina

; Cunha, Luciane Gomes da

; Zaupa, Ana Paula Berni

; Krauzer, João Ronaldo Mafalda

; Pires, Aristóteles de Almeida

; Cabral, Felipe Cezar

; Moreira, Tais de Campos

; Constant, Hilda Maria Rodrigues Moleda

Critical Care Science

Journal Metrics
- Sobre o periódico
- SciELO Analytics

sep 2023, Volume 35 N. 3 Pages 266 - 272

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT The objective of this study is to present the protocol of a cluster randomized clinical trial to be conducted through the TeleICU project - Qualification of Intensive Care by Telemedicine. The study will consist of a cluster randomized clinical trial, open label, in pediatric intensive care units, with an allocation ratio of 1:1, to compare the intervention group (support of Telemedicine for patients admitted to the pediatric intensive care unit) with a control group (pediatric intensive care unit usual care). The study proposed to select 16 pediatric intensive care units, including 100 participants per site, with a total of 1,600 participants. The intervention group will receive telerounds from Monday to Friday and will have specialists and continuing education activities available. The primary outcome measure will be the length of stay in the pediatric intensive care unit, defined as the difference between the date of discharge of the participant and the date of admission to the intensive care unit. The secondary outcomes will be mortality rate, invasive mechanical ventilation-free days, days using antibiotics, days using vasoactive drugs and days using sedoanalgesia. This study will be conducted in accordance with Resolution 466/12 of the National Health Council, with approval by the Research Ethics Committee of the institutions involved. The present study has the potential to reproduce studies on Telemedicine in intensive care and may make important contributions to care in intensive care units in Brazil and other settings. If Telemedicine shows positive clinical care results compared to conventional treatment, more pediatric patients may benefit. ClinicalTrials.gov registry: NCT05260710

RESUMO O objetivo deste estudo será apresentar o protocolo de um ensaio clínico randomizado em cluster a ser realizado por meio do projeto TeleUTI - Qualificação da Assistência em Terapia Intensiva por Telemedicina. O estudo consistirá em um ensaio clínico randomizado por cluster, open label, em unidades de terapia intensiva pediátricas, com proporção de alocação de 1:1, com o intuito de comparar o grupo de intervenção (apoio da telemedicina para os pacientes internados na unidade de terapia intensiva pediátrica) com um grupo controle (cuidados habituais da unidade de terapia intensiva pediátrica). O estudo se propõe a selecionar 16 unidades de terapia intensiva pediátricas, incluindo 100 participantes por local, com o total de 1.600 participantes. O grupo intervenção receberá telerounds de segunda-feira a sexta-feira e terá à disposição especialistas e atividades de educação continuada. O desfecho primário a ser avaliado será o tempo de permanência nas unidades de terapia intensiva pediátricas, definido pela diferença entre a data de alta do participante com a data de admissão na unidade de terapia intensiva. Os desfechos secundários serão: taxa de mortalidade; dias livres de ventilação mecânica, dias de uso de antibióticos, dias de uso de drogas vasoativas e dias de uso de sedoanalgesia. Este estudo será conduzido em conformidade com a resolução 466/12 do Conselho Nacional de Saúde, com aprovação pelo Comitê de Ética em Pesquisa das instituições hospitalares envolvidas. O trabalho tem o potencial de reproduzir estudos sobre Telemedicina em cuidados intensivos, podendo trazer contribuições importantes ao atendimento em unidades de terapia intensiva no Brasil e em outras realidades. Se a Telemedicina mostrar resultados clínicos assistenciais positivos em relação ao tratamento convencional, mais pacientes pediátricos poderão ser beneficiados. Registro ClinicalTrials.gov: NCT05260710

https://doi.org/10.5935/2965-2774.20230223-en

15.

Envejecimiento saludable: un primer acercamiento a la revisión de indicadores subjetivos de salud en zonas urbanas y rurales en Costa Rica
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Blanco- Molina, Mauricio

; Castro-Rojas, María Dolores

; Ortega-Moreno, Raúl

Interdisciplinaria

Journal Metrics
- Sobre o periódico
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aug 2023, Volume 40 N. 2 Pages 281 - 298

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen En este artículo se presentan los resultados de una primera aproximación al análisis del efecto moderador del contexto social, cultural y geográfico en indicadores subjetivos del envejecimiento saludable en personas mayores de 46 años residentes en territorios con características diferenciadas en Costa Rica. Se trabajó con una muestra de 305 personas residentes en tres áreas geográficas: una urbana, una semiurbana y una tercera principalmente rural. La diferenciación de las tres zonas se basó en criterios de densidad poblacional, infraestructura y acceso a bienes y servicios. Los indicadores subjetivos del envejecimiento saludable analizados fueron: participación social, apoyo social, salud percibida, espiritualidad, autoeficacia, comportamientos de autocuidado, bienestar subjetivo (satisfacción con la vida y bienestar psicológico) y estado de ánimo; todas las variables fueron condicionadas por zona de residencia, edad y sexo. Para analizar los indicadores subjetivos se estimó un análisis de covarianza (ANCOVA) o un análisis multivariado de covarianza (MANCOVA), dependiendo del número de variables dependientes analizadas. En general, se identificaron indicadores subjetivos de envejecimiento saludable altos en las personas participantes del estudio, quienes reportaron altos niveles de participación social, satisfacción con la vida y estados de salud y ánimo positivos. Se encontraron diferencias por edad entre los grupos. Sin embargo, no se evidenciaron diferencias estadísticamente significativas en los indicadores subjetivos analizados según la zona de residencia o el sexo. En síntesis, este estudio encontró que los indicadores subjetivos de envejecimiento saludable analizados eran muy similares en residentes de tres zonas geográficas con características distintas. Estos hallazgos iniciales se discuten desde una perspectiva cultural y geográfica y en relación con los modelos de envejecimiento saludable.

Abstract This review exposes the results of a first approximation to the analysis of the moderator effect of the geographical, social, and cultural context on subjective indicators of healthy aging in the Costa Rican context. Costa Rica is a middle-income democratic country that is in an advanced demographic changing process; this phenomenon makes it one of the aged countries in the Latin American region. Therefore, studying healthy aging becomes relevant in the context of population demographic change in the present and future aging societies. The study compared several subjective indicators of healthy aging among people older than 46 who resided in three different geographical areas in the country. Participants were 305 healthy people from three locations: one urban (Heredia Central City), one semi-urban (Santa Ana Central City), and one mainly rural (Nicoya). Participants completed standardized assessment scales to evaluate social participation, social support, perceived health, spirituality, self-efficacy, self-care behaviors, and subjective well-being (life satisfaction and psychological well-being). All variables were conditioned by geographical zone (urban, semi-urban, and mainly rural), age, and gender. Either Analysis of Covariance (ANCOVA) or Multivariate Analysis of Covariance (MANCOVA) were estimated depending on the number of dependent variables analyzed to test the effect of the zone of residence, gender, and age, over the subjective indicator of healthy aging studied. In general, participants evidenced high scores on subjective indicators such as self-care, social support, spirituality, life satisfaction, and psychological well-being, which have been associated with health and well-being during the aging process. Participants reported high levels of social participation and perceived that they received adequate support for their daily life needs. Likewise, participants evidenced a general state of well-being, a positive state of health, high levels of self-efficacy, and positive moods. Differences were found among the groups by comparing age. However, no significant differences were found in the variables studied related to geographical areas of residence and sex, suggesting invariant comparison evidence by zone of residence and sex. Nevertheless, the results indicate that the subjective indicators of healthy aging studied are key to promoting healthy aging at the national level. It is considered necessary to improve opportunities for social participation aimed at older adults, to strengthen community and family social networks, to promote socio-economic support such as financial and instrumental support for activities of daily living, and finally emotional support such as listening, empathy and advice. Although the differences among geographical areas of residence of the people studied were not statistically significant in this study, the evidence suggested a trend of high well-being indicators mainly in the rural areas studied, and particularly more in males than in females. As this study only reached preliminary data, further research must obtain conclusive evidence, as previous research had suggested older people living in rural areas with high longevity indicators in Costa Rica might enjoy unusual environmental characteristics and personal protective factors that could be absent in most of the urban areas in the country. On the other hand, it will be necessary to include the historical and socio-cultural determinants focusing on context-specific review analyses in the mainstream research on healthy aging, even more in aged countries like Costa Rica. The findings are discussed within the inter-cultural emphasis and healthy aging models in order to contribute to a better understanding of how the context (physical-constructed and social/cultural) influences the differences, although subtle, in the study´s variables and participants, and how the process of aging might be different according to the multiple contextual conditions in which people live and adapt their capacities and abilities for coping with daily life demands.

https://doi.org/10.16888/interd.2023.40.2.17

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