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Abstract The aim of this study was to evaluate the osseointegration of a hydrophilic surface (blasting + acid etching + immersion in isotonic solution) in comparison with that of a control surface (blasting + acid etching) using an experimental model of low-density bone. To perform the study, 24 rabbits were submitted to the installation of 4 implants in the iliac bone bilaterally: 2 implants with a control surface and 2 implants with a hydrophilic surface. The rabbits were euthanized at 2, 4, and 8 weeks after implant installation. After euthanasia, one implant from each surface was used to perform the removal torque analysis, and the other implant was used for the execution of non-decalcified histological sections and evaluation of the bone implant contact (% BIC) as well as the fraction of bone tissue area between the implant threads (% BBT). The implants with a hydrophilic surface presented higher %BIC (42.92 ± 2.85% vs. 29.49 ± 10.27%) and % BBT (34.32 ± 8.52% vs. 23.20 ± 6.75%) (p < 0.05) in the 2-week period. Furthermore, the hydrophilic surface presented higher removal torque in the 8-week period (76.13 ± 16.00 Ncm2 vs. 52.77 ± 13.49 Ncm2) (p<0.05). Implants with a hydrophilic surface exhibited acceleration in the process of osseointegration, culminating in greater secondary stability in low-density bone than in implants with a control surface.

Resumo O objetivo deste estudo foi avaliar a osseointegração de uma superfície hidrofílica (jateamento + ataque ácido + imersão em solução isotônica) em comparação com uma superfície controle (jateamento + ataque ácido) usando um modelo experimental de osso de baixa densidade. Para realizar o estudo, 24 coelhos foram submetidos a instalação de 4 implantes bilateralmente no osso ilíaco: 2 implantes com superfície controle e 2 implantes com superfície hidrofílica. Os coelhos foram eutanasiados com 2, 4 e 8 semanas após a instalação dos implantes. Após a eutanásia, um implante de cada superfície foi usado para avaliar o torque de remoção, e o outro implante foi utilizado para execução de cortes histológicos não descalcificados e avaliação de contato osso implante (% BIC) bem como a fração da área tecido ósseo entre as roscas do implante (% BBT). Os implantes com superfície hidrofílica apresentaram maior %BIC (42.92 ± 2.85% vs. 29.49 ± 10.27%) e % BBT (34.32 ± 8.52% vs. 23.20 ± 6.75%) (p < 0.05) no período de 2 semanas. Além disso, a superfície hidrofílica apresentou maior torque de remoção no período de 8 semana (76.13 ± 16.00 Ncm2 vs. 52.77 ± 13.49 Ncm2) (p<0.05). Implantes com a superfície hidrofílica apresentaram aceleração no processo de osseointregração, culminando em melhor estabilidade secundária no osso de baixa densidade em relação a implantes com superfície controle.

https://doi.org/10.1590/0103-6440202305352

Evaluating the Global Forecast System (GFS) for energy management over Minas Gerais State (Brazil) against in-situ observations
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de Oliveira Filho, Rafael Arcanjo

; Barreto Carvalho, Vanessa Silveira

; Simões Reboita, Michelle

Atmósfera

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2022, Volume 35 N. 2 Pages 357 - 376

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Several regions of Brazil have experienced periods of intense drought in the last decades. Hydropower plants produce most of the country’s energy and a reduction in reservoir flow can compromise the energy sector. Therefore, the Brazilian government has sought the diversification of energy production with other renewable sources. The introduction of new renewable sources, such as wind and solar, requires detailed studies of the local weather conditions usually through historical data analysis. However, several areas in Brazil lack weather stations. In this context, this study aims to assess the ability of the Global Forecast System (GFS) reanalysis product to represent wind, in the state of Minas Gerais (MG) which has 79.5% of energy production associated with water resources. Although the study considers a specific region, it presents a methodology that can be replicated in regions where data is not available. Over most areas, 10 m wind speed values of the GFS reanalysis were similar to those registered by weather stations. Results at 10 and 100 m of altitude show high wind speed values in the north of the state, a region where the highest power densities are also recorded (approximately 150 W m-2 during winter and spring). In conclusion, the GFS reanalysis product, albeit with the biases reported here, can be used in regions with scarce meteorological data to estimate the potential for wind energy production as a complementary source of hydroelectricity.

RESUMEN Varias regiones de Brasil han experimentado períodos de intensa sequía en las últimas décadas. Las centrales hidroeléctricas producen la mayor parte de la energía del país y una reducción en el caudal de los embalses puede comprometer al sector energético. Por lo tanto, el gobierno brasileño ha buscado la diversificación de la producción de energía con otras fuentes renovables. La introducción de nuevas fuentes renovables, como energía eólica y solar, requiere estudios detallados de las condiciones climáticas locales, generalmente a través del análisis de datos históricos. Sin embargo, varias áreas de Brasil no tienen buena densidad de estaciones meteorológicas. En dicho contexto, este estudio tiene como objetivo evaluar la capacidad del producto de reanálisis del Sistema de Pronóstico Global (GFS) para representar el viento en el estado de Minas Gerais (MG), que produce el 79.5% de la energía de recursos hídricos. Si bien el estudio considera una región específica, presenta una metodología que se puede replicar en regiones donde no hay datos disponibles. En la mayoría de las áreas los valores de velocidad del viento a 10 m de GFS fueron similares a los registrados por las estaciones meteorológicas. Los resultados a 10 y 100 m de altitud muestran altos valores de velocidad del viento en el norte del estado, región donde también se registran las mayores densidades de potencia (~150 W m-2 durante invierno y primavera). En conclusión, el producto de reanálisis GFS, aunque con los sesgos aquí reportados, puede ser utilizado en regiones con datos meteorológicos insuficientes para estimar el potencial de producción de energía eólica como fuente complementaria de hidroelectricidad.

https://doi.org/10.20937/atm.52916 23 downloads

COVID-19 and isolation: Risks and implications in the scenario of new variants
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Dias, Viviane Maria de Carvalho Hessel

; Oliveira, Alexandre Ferreira

; Marinho, Ana Karolina Barreto Berselli

; Santos Ferreira, Carlos Eduardo dos

; Domingues, Carlos Eduardo Ferreira

; Fortaleza, Carlos Magno Castelo Branco

; Vidal, Claudia Fernanda de Lacerda

; Carrilho, Claudia Maria Dantas de Maio

; Pinheiro, Debora Otero Britto Passos

; de Assis, Denise Brandão

; Medeiros, Eduardo Alexandrino

; Morejón, Karen Mirna Loro

; Weissmann, Leonardo

; Michelin, Lessandra

; Carneiro, Marcelo

; Nogueira, Maria Dolores Santos da Purificação

; de Oliveira, Priscila Rosalba Domingos

; Buralli, Rafael Junqueira

; Stucchi, Raquel Silveira Bello

; Lins, Rodrigo Schrage

; Costa, Silvia Figueiredo

; Chebabo, Alberto

Brazilian Journal of Infectious Diseases

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2022, Volume 26 N. 5 elocation 102703

Abstract: En | Text: En | PDF: En

Abstract With the emergence of new variants of SARS-CoV-2, questions about transmissibility, vaccine efficacy, and impact on mortality are important to support decision-making in public health measures. Modifications related to transmissibility combined with the fact that much of the population has already been partially exposed to infection and/or vaccination, have stimulated recommendations to reduce the isolation period for COVID-19. However, these new guidelines have raised questions about their effectiveness in reducing contamination and minimizing impact in work environments. Therefore, a collaborative task force was developed to review the subject in a non-systematic manner, answering questions about SARS-CoV-2 variants, COVID-19 vaccines, isolation/quarantine periods, testing to end the isolation period, and the use of masks as mitigation procedures. Overall, COVID-19 vaccines are effective in preventing severe illness and death but are less effective in preventing infection in the case of the Omicron variant. Any strategy that is adopted to reduce the isolation period should take into consideration the epidemiological situation of the geographical region, individual clinical characteristics, and mask for source control. The use of tests for isolation withdrawal should be evaluated with caution, due to results depending on various conditions and may not be reliable.

https://doi.org/10.1016/j.bjid.2022.102703

Proteína C-reativa como Marcador Prognóstico de Mortalidade no Primeiro Ano após Implante de Válvula Aórtica Transcateter em Estenose Aórtica
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Sousa, André Luiz Silveira

; Carvalho, Luiz Antônio Ferreira

; Salgado, Constantino González

; Oliveira, Rafael Lauria de

; Lima, Luciana Cristina Correia Lima e

; Mattos, Nelson Durval Ferreira Gomes de

; Fagundes, Francisco Eduardo Sampaio

; Colafranceschi, Alexandre Siciliano

; Mesquita, Evandro Tinoco

Arquivos Brasileiros de Cardiologia

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nov 2021, Volume 117 N. 5 Pages 1018 - 1027

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento: A proteína C-reativa (PCR) é um biomarcador de inflamação preditor de eventos adversos em procedimentos cardiovasculares. Na avaliação do implante da válvula aórtica transcateter (transcatheter aortic valve implantation, TAVI) em relação ao prognóstico de longo prazo ainda é incipiente. Objetivo: Avaliar a PCR como marcador prognóstico no primeiro ano pós-TAVI na estenose aórtica (EAo). Métodos: A PCR foi avaliada na primeira semana do peroperatório numa coorte de casos retrospectiva com EAo. Correlacionou-se a PCR pré- e pós-TAVI com a mortalidade e foram pesquisados fatores preditores de mortalidade em 1 ano. Realizada regressão de Cox multivariada para identificar os preditores independentes de óbito em 1 ano. Resultados: Estudados 130 pacientes submetidos a TAVI, com mediana de idade de 83 anos, sendo 49% deles do sexo feminino. A PCR pré-TAVI elevada (> 0,5 mg/dL) ocorreu em 34,5% dos casos. O pico de PCR foi 7,0 (5,3-12,1) mg/dL no quarto dia. A mortalidade em 1 ano foi 14,5% (n = 19), sendo maior nos grupos com PCR pré-TAVI elevada (68,8% vs 29,1%; p = 0,004) e pico de PCR ≥ 10,0 mg/dL (64,7% vs 30,8%; p = 0,009). Os fatores preditores independentes de mortalidade foram insuficiência renal aguda (IRA) [razão de risco (RR) = 7,43; intervalo de confiança de 95% (IC95%), 2,1-24,7; p = 0,001], PCR pré-TAVI elevada [RR = 4,15; IC95%, 1,3-12,9; p=0,01] e hemotransfusão volumosa [HR = 4,68; 1,3-16,7; p = 0,02]. Conclusões: A PCR pré-TAVI elevada mostrou-se fator preditor independente de mortalidade no primeiro ano, assim como a ocorrência de IRA e hemotransfusões volumosas.

Abstract Background: C-reactive protein (CRP) is an inflammation biomarker that can be a predictor of adverse events in cardiovascular procedures. Its use in the assessment of long-term prognosis of transcatheter aortic valve implantation (TAVI) is still incipient. Objective: To evaluate CRP as a prognostic marker in the first year after TAVI in aortic stenosis (AoS). Methods: CRP was assessed on the first postoperative week in a retrospective cohort of patients with AoS. Pre- and post- CRP levels were correlated with mortality, and predictors of 1-year mortality were investigated. Multivariate Cox regression was performed to identify independent factors of 1-year mortality. Results: This study evaluated 130 patients who underwent TAVI, with median age of 83 years, and 49% of women. High pre-TAVI CRP (> 0.5 mg/dL) was observed in 34.5% of the cases. Peak CRP was 7.0 (5.3-12.1) mg/dL no quarto dia. The rate of 1-year mortality was 14.5% (n = 19), being greater in the groups with high pre-TAVI CRP (68.8% vs 29.1%; p = 0,004) and with peak CRP ≥ 10.0 mg/dL (64.7% vs 30.8%; p = 0,009). Independent predictors of mortality were acute renal failure (ARF) (hazard ratio [HR] = 7.43; 95% confidence interval [95%CI], 2.1-24.7; p = 0,001), high pre-TAVI CRP (HR 4.15; 95%CI, 1.3-12.9; p = 0.01), and large blood transfusion [HR 4,68; 1,3-16,7; p = 0.02]. Conclusions: High pre-TAVI CRP showed to be an independent predictor of 1-year mortality, as well as the presence of ARF and large blood transfusions.

https://doi.org/10.36660/abc.20190715 2 downloads

Association between SNP rs527616 in lncRNA AQP4-AS1 and susceptibility to breast cancer in a southern Brazilian population
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Marchi, Rafael D.

; Mathias, Carolina

; Reiter, Gabriel A. K.

; Lima, Rubens Silveira de

; Kuroda, Flávia

; Urban, Cícero de Andrade

; Souza, Ricardo. L. R. de

; Gradia, Daniela F.

; Ribeiro, Enilze M. S. F.

; Cavalli, Iglenir J.

; Oliveira, Jaqueline Carvalho de

Genetics and Molecular Biology

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2021, Volume 44 N. 1 elocation e20200216

Abstract: En | Text: En | PDF: En

Abstract Breast cancer (BC) is the leading cause of death by this disease in women worldwide. Among the factors involved in tumorigenesis, long non-coding RNAs (lncRNAs) and their differential expression have been associated. Differences in gene expression may be triggered by variations in DNA sequence, including single nucleotide polymorphisms (SNPs). In the present study, we analyzed the rs527616 (C>G), located in the lncRNA AQP4-AS1, using PCR-SSP in 306 BC patients and 312 controls, from a Brazilian population. In the BC group, the frequency found for CG heterozygotes was above the expected and the overdominant model is the best one to explain our results (OR: 1.70, IC 95%: 1.23-2.34, P<0.001). Furthermore, the SNP were associated with age at BC diagnosis and the risk genotype more frequent in the older age group. According to TCGA data, AQP4-AS1 is down-regulated in BC tissue, and the overexpression is associated with better prognoses, including Luminal A, HER2-, stage 1 of disease and smaller tumor. In conclusion, the CG genotype is associated with increased susceptibility in the southern Brazilian population. This SNP is mapped in the lncRNA AQP4-AS1, showing differential expression in BC samples. Based on these results, we emphasize the potential of the role of AQP4-AS1 in cancer.

https://doi.org/10.1590/1678-4685-gmb-2020-0216 788 downloads

Head and neck cancer therapy-related oral manifestation management in the COVID-19 pandemic: a critical review
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MIRANDA, Rafael Resende de

; LOPES, Camila de Carvalho Almança

; FRANCO, Nathália Maria Afonso Silveira

; CABRAL, Luana Cardoso

; SIMAMOTO JÚNIOR, Paulo Cézar

; NOVAIS, Veridiana Resende

Brazilian Oral Research

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2020, Volume 34 elocation e120

Abstract: En | Text: En | PDF: En

Abstract With the onset of the new coronavirus disease (COVID-19) pandemic, the dental treatment of patients at risk of infection has become quite challenging. In view of this, patients with head and neck cancer may present with oral complications due to anticancer therapy, making dental assistance necessary. Thus, the objective of the study was to review the literature and critically discuss important concerns about the treatment of patients with head and neck cancer during the COVID-19 pandemic. Because dental professionals are in close contact with the main viral transmission routes, this study presents recommendations for management and protection during clinical dental care. The main characteristics and transmission routes of COVID-19 are also discussed. Dental professionals should control pain and the side effects of antineoplastic treatment and use preventive measures for infection control. During this pandemic, patients with head and neck cancer should not undergo elective procedures, even if they do not have symptoms or a history of COVID-19; therefore, in asymptomatic or painless cases, only preventive actions are recommended. In symptomatic or painful cases, precautions for safe interventional treatments must be implemented by following the hygiene measures recommended by health agencies and using personal protective equipment. During health crises, new protocols emerge for cancer treatment, and professionals must act with greater attention toward biosafety and updated knowledge. It is important to offer adequate individualized treatment based on the recommendations of preventative and interventional treatments so that patients can face this difficult period with optimized quality of life.

https://doi.org/10.1590/1807-3107bor-2020.vol34.0120 1175 downloads

Outbreak of multidrug resistant Salmonella Typhimurium in calves at a veterinary hospital in Brazil
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Ramos, Carolina Pantuzza

; Vespasiano, Letícia Camêlo

; Melo, Isabela Oliveira

; Xavier, Rafael Gariglio Clark

; Leal, Carlos Augusto Gomes

; Facury Filho, Elias Jorge

; Carvalho, Antônio Ultimo de

; Lobato, Francisco Carlos Faria

; Silva, Rodrigo Otávio Silveira

Ciência Rural

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2019, Volume 49 N. 2 elocation 20180788

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O objetivo do presente estudo é descrever e caracterizar um surto nosocomial provocado por S. Typhimurium multirresistente em bezerros hospitalizados em um hospital escola de medicina veteriária localizado no Brasil. Sessenta e três (96,9%) bezerros apresentaram letargia, hipertermia e diarreia profusa e, apesar do tratamento, vinte e seis animais (41,2%) morreram. Cinco animais foram necropsiados e amostras fecais de seis bezerros foram coletadas. As estirpes isoladas foram submetidas a testes de susceptibilidade a antimicrobianos pelo método de disco-difusão e foram genotipadas pelo ERIC-PCR. Lesões macroscópicas sugestivas de salmonelose, como enterite fibrinonecrótica e hepatoesplenomegalia, foram observadas. Salmonelose foi confirmada pelo isolamento de S. Typhimurium em amostras fecais e órgãos de sete animais. Dos sete isolados, seis apresentaram 100% de similaridade ao ERIC-PCR, sugerindo ocorrẽncia de transmissão nosocomial de S. Typhimurium entre os bezerros hospitalizados. Com excessão de uma estirpe, todas foram resistentes a marbofloxacina, enrofloxacina, florfenicol, oxitetraciclina e trimetoprima/sulfametoxazol, agentes antimicrobianos amplamente utilizados para o tratamento humano e animal. Esse é o primeiro estudo que demonstra um surto nosocomial de estirpes de S. Typhimurium resistentes a múltiplas drogas em um hospital veterinário no Brasil, enfatizando a necessidade de medidas preventivas que reduzam os riscos aos animais hospitalizados e a pessoas que entrarem em contato com esses animais.

ABSTRACT: The present study aimed to describe and characterize a nosocomial outbreak caused by a multidrug resistant Salmonella Typhimurium in hospitalized calves at a veterinary medical teaching hospital from Brazil. Sixty-three (96.9%) calves showed lethargy, hyperthermia and profuse diarrhea and despite treatment, 26 (41.2%) animals died. Five animals were necropsied and stool samples of six calves were collected. The isolated strains were subjected to antimicrobial susceptibility test by disc-difusion method and were fingerprinted by ERIC-PCR. Macroscopic lesions suggestive of salmonellosis, such as fibrinonecrotic enteritis and hepatosplenomegaly were observed. Salmonellosis was confirmed by isolation of S. Typhimurium from stool samples and organs from seven affected animals. Six out of seven isolates of S. Typhimurium, exhibited 100% of similarity at ERIC-PCR, suggesting occurrence of nosocomial transmission of S. Typhimurium among the hospitalized calves. All but one S. Typhimurium isolated were resistant to marbofloxacin, enrofloxacin, florfenicol, oxytetracycline and trimethoprim/sulfamethoxazole, antimicrobial agents largely used for humans and animal treatment. This is the first study of a nosocomial outbreak of multidrug resistant S. Typhimurium in a veterinary hospital in Brazil and highlighted the need for preventive measures to reduce the risks for inpatients and humans in contact with animals.

https://doi.org/10.1590/0103-8478cr20180788 1234 downloads

Antimicrobial susceptibility and molecular characterization of Salmonella serovar Ndolo isolated from outbreaks in cattle and horses
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Ramos, Carolina Pantuzza

; Xavier, Rafael Gariglio Clark

; Leal, Carlos Augusto Gomes

; Facury Filho, Elias Jorge

; Carvalho, Antonio Ultimo de

; Viegas, Flávia Mello

; Pires, Isadora Honorato

; Lopes, Emily Oliveira

; Lobato, Francisco Carlos Faria

; Silva, Rodrigo Otávio Silveira

Ciência Rural

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2018, Volume 48 N. 12 elocation e20180688

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O objetivo do presente estudo foi descrever e caracterizar, pela primeira vez, dois surtos de salmonelose causados por Salmonella Ndolo em potros e bezerros do Brasil e comparar esses isolados com Salmonella Ndolo previamente identificada em répteis assintomáticos. Os animais infectados apresentaram febre, letargia e diarreia profusa. Os isolados foram submetidos a testes de susceptibilidade a antimicrobianos e foram caracterizados conforme a presença de genes de virulência e diversidade genética, utilizando-se o ERIC-PCR. Salmonella Ndolo foi identificado em amostras fecais de dois potros e quatro bezerros. Um isolado de bezerro foi resistente a amoxicilina/ácido clavulanico, trimethoprima/sulfametoxazol e florfenicol. Estirpes de dois outros bezerros foram resistentes a oxitetraciclina. Todos os genes de virulência testados foram identificados nos isolados e dois grandes grupos de estirpes geneticamente relacionadas foram identificados pelo ERIC-PCR, um para cada surto. Esse é o primeiro relato de Salmonella Ndolo em animais domésticos e sintomáticos. Previamente, esse sorovar foi identificado apenas em infecções humanas. A presença de fatores de virulência relevantes em todos os isolados e a detecção de estirpes multirresistentes a antimicrobianos destaca a importância do monitoramento de sorovares associados a salmonelose em animais domésticos.

ABSTRACT: The present study aimed to describe and characterize, for the first time, two outbreaks of salmonellosis caused by Salmonella Ndolo in foals and calves in Brazil and compare the isolated strains with S. Ndolo previously identified in asymptomatic reptiles. The affected calves and foals presented fever, lethargy, and profuse diarrhea. Isolated strains were subjected to antimicrobial susceptibility testing, characterized according to virulence genes, and fingerprinted by ERIC-PCR. Salmonella Ndolo was identified in fecal samples from two foals and four calves. One isolate from a calf was resistant to amoxicillin/clavulanic acid, trimethoprim/sulfamethoxazole, and florfenicol. Strains from two other calves were resistant to oxytetracycline. All virulence genes tested were present in the isolates, and two major clusters of closely related strains were identified by ERIC-PCR, each per outbreak. This is the first report of Salmonella Ndolo infection in domestic and symptomatic animals. Previously, this serovar had been identified only in human infections. The presence of relevant virulence genes in all Salmonella Ndolo isolates and the detection of antimicrobial multi-resistant strains highlighted the importance of monitoring serovars associated with salmonellosis in domestic animals.

https://doi.org/10.1590/0103-8478cr20180688 1448 downloads

Physical exercise on serum electrolytes and acid base balance in Mangalarga Marchador horses submitted to cavalcade of 4, 8 and 20km
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Linhares, Jessica Martins

; Filippo, Paula Alessandra Di

; Bogossian, Paulo Moreira

; Guerra, Rafael Vianna Barbosa de Almeida

; Bustamante, Sebastian Ricardo Bustamante

; Carvalho, Cláudio Baptista de

; Ferreira, Felipp da Silveira

Ciência Rural

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2017, Volume 47 N. 5 elocation e20160277

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Distúrbios ácido-base e eletrolíticos têm sido descritos em cavalos durante e após diferentes modalidades de exercícios. Este estudo foi realizado com o objetivo de investigar o efeito do esforço físico de cavalgada sobre o equilíbrio ácido base e hidroeletrolítico de cavalos da raça Mangalarga Marchador. Quinze cavalos castrados com média de idade de 6.2±1.2 anos foram distribuídos em três grupos com 05 indivíduos cada. Os animais percorreram percursos de 4 (G4), 8 (G8) e 20 (G20) km de extensão os quais, foram realizados à velocidade média de 15km h-1, 12km h-1 e 12km h-1, respectivamente. Íon bicarbonato (HCO3 -), pH, pressão parcial de dióxido de carbono (pCO2), pressão parcial de oxigênio (pO2), excesso de bases (BE), hematócrito (Hct), sódio (Na+), potássio (K+), cloreto (Cl-) e lactato foram mensurados. As variáveis pH, pO2 e pCO2 foram corrigidas em função da temperatura corporal dos animais. De cada cavalo, amostras de sangue venoso foram coletadas antes do exercício (T0) e após o término da cavalgada (T1). As amostras foram analisadas através do i-STAT. Houve aumento (P<0,05) nos valores de Hct, Na+, pH, HCO3 - e BE nos animais do G20, após o término da cavalgada (T1). Após a cavalgada, os animais do G20 apresentaram ainda diminuição na concentração de K+ e de Cl-. As alterações no equilíbrio ácido-base e hidroeletrolítico pós-cavalgada de 20km resultou em alcalose metabólica hipoclorêmica. O esforço físico de cavalgada de 20km resultou em desequilíbrios hidroeletrolíticos e ácido-base significativos em cavalos da raça Mangalarga Marchador.

ABSTRACT: Acid-base and electrolyte disorders have been described in horses associated during and after exercise. The aim of the present study was to evaluate the effect of cavalcade competition on the acid-base and hydroelectrolytic balance in Mangalarga Marchador horses. For this purpose, 15 geldings, 6.2 ± 1.2 years old and clinically healthy, were distributed into three groups of five animals each. Horses were trained to take part in cavalcade competitions. Animals were submitted to cavalcade along 4km (G4), 8km (G8), and 20km (G20) at mean speeds of 15km h-1, 12km h-1, and 12km h-1, respectively. From each horse, venous blood samples were collected before exercise (T0) and immediately after (T1) cavalcade. Bicarbonate ion (HCO3-), pH, partial pressure of carbon dioxide (pCO2), partial pressure of oxygen (pO2), base excess (BE), hematocrit (Hct), sodium (Na+), potassium (K+), chloride (Cl-) and lactate were determined. The variables pH, pO2 and pCO2 were corrected in function of rectal temperature of each animal. Blood samples were analyzed for acid-base balance, as well as biochemical and electrolyte parameters using an i-STAT analyzer. Significant (P<0.05) increase in Hct, Na+, pH, HCO3 - and BE were observed after cavalcade in G20 group. Decrease (P<0.05) in K+ and Cl- were also observed in G20 animals after cavalcade (T1). Changes in the acid-base balance and hydroelectrolytic profile of the Mangalarga Marchador after cavalcade of 20km resulted in hypochloremic metabolic alkalosis. The 20km cavalcade induced significant hydroelectrolytic and acid-base imbalances in Mangalarga Marchador horses.

https://doi.org/10.1590/0103-8478cr20160277 2612 downloads

10.

Unusual intrathoracic foreign body: tree branch
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Corrêa, Diogo Goulart

; Salata, Tiago Medina

; Teixeira, Luiz Sérgio Carvalho

; Borges, Rafael Silveira

; Marchiori, Edson

Radiologia Brasileira

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oct 2016, Volume 49 N. 5 Pages 345 - 346

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/0100-3984.2015.0182 1027 downloads

11.

Muertes por accidente de motocicleta y su asociación con variables relacionadas a la reproducción social en un estado del noreste brasileño
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Silva, Paul Hindenburg Nobre de Vasconcelos

; Lima, Maria Luiza Carvalho

; Souza, Wayner Vieira

; Moreira, Rafael da Silveira

; Oliveira, Fernando José Moreira

Salud colectiva

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sep 2015, Volume 11 N. 3 Pages 401 - 410

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

The objective of this article was to identify the association between motorcycle deaths and variables related to Samaja's theory of social reproduction in the period 2000-2005 in the state of Pernambuco. An ecological, case-control study was carried out, with municipalities as the unit of analysis. Cases were defined as the 20% of municipalities with the highest local empirical Bayesian coefficients for mortality due to motorcycle accidents, and controls as the 40% with the lowest coefficients. The municipalities with the greatest chances of high coefficients for mortality due to motorcycle accidents showed high population growth factors and increases in the total fleet of motorcycles, with low population densities, low GDP per capita, and more than 20 motorcycles per thousand inhabitants. We conclude that the variables related to macro-policies proved to have greater force in explaining higher chances of motorcycle death.

El objetivo de este artículo es identificar el comportamiento de las muertes por accidentes de motocicleta y las variables relacionadas con la teoría de la reproducción social de Samaja, para el período 2000-2005 en el estado de Pernambuco, Brasil. Se realizó un estudio ecológico con abordaje caso-control. La unidad de análisis fue el municipio. Los casos fueron definidos considerando el 20% de los municipios con los mayores coeficientes bayesianos empíricos locales de mortalidad por accidentes de motocicleta y los controles, como el 40% de los municipios con menores coeficientes de mortalidad por accidentes de motocicleta. Los municipios con mayor probabilidad de altos coeficientes de mortalidad por accidentes de motocicleta mostraron factores de crecimiento poblacional altos, así como de crecimiento de la flota de vehículos, bajas densidades demográficas, bajo PBI per cápita, y más de 20 motocicletas por mil habitantes. Se concluye que las variables relacionadas a las macropolíticas mostraron una mayor fuerza para explicar las probabilidades de defunciones por accidentes de motocicleta.

https://doi.org/10.18294/sc.2015.724 1091 downloads

12.

Occurrences of Oestrus ovis parasitism in necropsied sheep in the Umuarama microregion, Paraná, Brazil
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Carvalho, Rafael Silveira

; Ruivo, Maycon Araújo

; Colli, Marcos Henrique Alcantara

; Pereira, Valdomiro

; Martinez, Antônio Campanha

; Mazzucatto, Barbara Cristina

; Cruz, Breno Cayeiro

; Maciel, Willian Giquelin

; Felippelli, Gustavo

; Teixeira, Weslen Fabricio Pires

; Soares, Vando Edésio

; Costa, Alvimar José da

; Lopes, Welber Daniel Zanetti

Revista Brasileira de Parasitologia Veterinária

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sep 2015, Volume 24 N. 3 Pages 370 - 374

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

De janeiro de 2007 a setembro de 2013, foram avaliados, durante a necropsia, 71 ovinos pertencentes a 12 propriedades rurais da microrregião de Umuarama, Paraná, Brasil, quanto à presença de larvas de Oestrus ovis. Entre outubro e dezembro de 2013, as 12 propriedades de onde os animais eram provenientes foram visitadas, e os proprietários e funcionários foram entrevistados. A ocorrência do parasitismo por O. ovis em ovinos foi constatada pela primeira vez em propriedades rurais da microrregião de Umuarama, Estado do Paraná. Dos 71 animais, 12 (16,9%) estavam parasitados por O. ovis, com intensidade média de parasitismo de 2,25 larvas por cabeça infestada (1 a 8 larvas). Foi possível verificar correlação elevada (0,81, p=0,0346) apenas entre o número de larvas versuslesões macroscópicas observadas na cavidade nasal desses animais, de modo que ovinos com mais de 3 larvas continham secreção mucopurulenta ou epistaxe na cavidade. Quando da entrevista constatou-se que todos os proprietários fazem controle químico contra parasitas (helmintos e/ou O. ovis) e esse. controle é feito a cada 30 dias por 91,6% dos produtores, que utilizam derivados de lactonas macrocíclicas e/ou benzimidazóis/imidatiazóis. Futuros estudos ainda precisam ser realizados nesta região, na tentativa de elucidar a prevalência de parasitismo por O. ovis nos rebanhos.

Between January 2007 and September 2013, 71 sheep belonging to 12 farms in the Umuarama microregion, State of Paraná, were evaluated regarding presence of Oestrus ovis larvae, during necropsies. The farms from which these animals originated were visited and the owners and employees were interviewed. Occurrences of O. ovis parasitism in sheep were diagnosed for the first time on this microregion. Of the 71 animals, 12 (16.9%) were parasitized by O. ovis, with mean intensity of 2.25 larvae per infested head (1 to 8 larvae/infested head). There was a high correlation (0.81, p=0.0346) between the number of larvae and the macroscopic lesions observed in these animals’ nasal cavities, such that sheep with more than 3 larvae may contain mucupurulent secretions or epistaxis. From the interviews conducted, it was found that all the farm owners were applying chemical parasite control methods (helminths and/or O. ovis), administered to all animals in the herds every 30 days (91.6% of the producers), using derivatives of macrocyclic lactones and/or benzimidazoles/imidazothiazoles. Further studies need to be conducted in this particular region, in an attempt to elucidate the prevalence of O. ovis parasitism in herds.

https://doi.org/10.1590/S1984-29612015044 1307 downloads

13.

Muertes por accidente de motocicleta y su asociación con variables relacionadas a la reproducción social en un estado del noreste brasileño
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Silva, Paul Hindenburg Nobre de Vasconcelos

; Lima, Maria Luiza Carvalho

; Souza, Wayner Vieira

; Moreira, Rafael da Silveira

; Oliveira, Fernando José Moreira

Salud Colectiva

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sep 2015, Volume 11 N. 3 Pages 401 - 410

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

https://doi.org/10.18294/sc.2015.724 2421 downloads

14.

Intoxicação de ovinos que receberam duas aplicações de closantel, na dosagem terapêutica (7,5mg/kg), com intervalo de 28 dias
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Lopes, Welber Daniel Zanetti

; Carvalho, Rafael Silveira

; Oliveira, Pedro Victor

; Pereira, Valdomiro

; Martinez, Antônio Campanha

; Mazzucatto, Barbara Cristina

; Colli, Marcos Henrique A.

; Ruivo, Maycon Araújo

Pesquisa Veterinária Brasileira

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dec 2014, Volume 34 N. 12 Pages 1162 - 1166

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O presente estudo notifica a intoxicação de ovinos que receberam duas aplicações de closantel, na dosagem terapêutica (7,5mg/kg), com intervalo de 28 dias pré-estabelecido pela eficácia da formulação. Referente aos resultados de eficácia foi possível observar elevado percentual após o primeiro e o segundo tratamento. Cerca de 72 horas após a administração do segundo tratamento (D+30), três animais que receberam closantel demonstraram leve apatia, anorexia, diarréia e cegueira bilateral com ausência de reflexo e midríase bilateral. Estes três ovinos foram observados por cerca de 250 dias após o segundo tratamento, e a cegueira bilateral não regrediu. Os inúmeros casos de animais intoxicados por closantel descritos na literatura enfatizam que a sobredosagem e/ou qualidade nutricional dos animais, são fatores determinantes para que ocorra intoxicação destes animais pelo closantel. Entretanto, no presente trabalho, os sinais de intoxicação (leve apatia, anorexia, diarréia e a alteração oftálmica) observada nos três ovinos clinicamente sadios, ocorreram quando estes receberam duas aplicações de closantel (7,5mg/kg) com o intervalo de 28 dias, evidenciando que o possível efeito residual cumulativo de closantel no organismo animal, desencadeado por duas aplicações consecutivas, também pode ser um fator predisponente para que ovinos demonstrem sinais irreversíveis de intoxicação pelo princípio ativo em questão.

This study reports poisoning in sheep wich have received two applications of closantel in therapeutic dosage (7.5mg/kg) within a preestablished 28-day period for effectiveness formulation. A high percentage of efficiency was observed after the first and second treatment, but around 72 hours after the second administration of closantel (D30), three sheep have showed mild apathy, anorexia, diarrhea, bilateral blindness, and dilated pupils without reaction. These three animals, were observed in the following 250 days, and the bilateral blindness remained. Numerous reports of animals poisoned by closantel emphasize that overdose and/or nutritional status of the animals are key factors to occur poisoning due closantel administration. However, in this experiment the signs of poisoning (mild apathy, anorexia, diarrhea and ophthalmic disturbance), observed in the three clinically healthy sheep, occurred when they received two applications of closantel (7.5mg/kg), in a interval of 28 days, highlighting the fact of obtaining a cumulative residual effect of closantel in the animal organism, caused by two consecutive applications, may also be a predisposing factor for sheep to demonstrate irreversible signs of intoxication.

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15.

Intoxicação aguda por triclorfon em caprinos tratados com a dose terapêutica
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Lopes, Welber Daniel Zanetti

; Carvalho, Rafael Silveira

; Gracioli, Diogo dos Passos

; Oliveira, Pedro Victor

; Pereira, Valdomiro

; Martinez, Antônio Campanha

; Mazzucatto, Barbara Cristina

Pesquisa Veterinária Brasileira

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feb 2014, Volume 34 N. 2 Pages 114 - 118

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O presente estudo descreve um surto de intoxicação por triclorfon em caprinos, que receberam pela via oral, a dosagem terapêutica do princípio ativo em questão (100mg/kg), provenientes da Universidade Estadual de Maringá, campus de Umuarama, PR. Cinquenta e três ovinos foram tratados com a mesma formulação/solução e não se observou nenhum efeito colateral nos animais referente ao tratamento com triclorfon. Das 20 cabras medicadas, cerca de 40 minutos após a administração do triclorfon, oito apresentaram os clássicos sinais clínicos de ataxia, decúbito externo-lateral, sialorreia, tremores, constrição das pupilas, dispneia com ruídos, micção e defecação involuntária, paresia espástica, timpanismo e lacrimejamento. Quase que imediatamente após a detecção destes sinais, as oito cabras foram medicadas com sulfato de atropina 1% 0,5mg/kg mais fluidoterapia. Cinco destes animais tiveram de receber nova dosagem de sulfato de atropina uma hora após a primeira aplicação, em função de alguns sinais clínicos, como tremores musculares, ainda estarem presentes. De 48 a 72 horas após a administração do triclorfon, três destes cinco animais vieram a óbito. Na necropsia, foi possível observar mucosas cianóticas, congestão de fígado, baço e rins, vasos mesentéricos congestos, vesícula biliar repleta, enfisema pulmonar, parênquima pulmonar avermelhado. Os resultados encontrados neste trabalho chamam atenção que o surto aconteceu em cabras adultas, que apresentavam boas condições clínicas e acima de tudo, receberam a dosagem terapêutica recomendada em bula pelo fabricante. Talvez isso possa indicar alguma sensibilidade mais elevada desta espécie animal à dosagem recomendada em bula do triclorfon (100mg/kg) para caprinos.

The present study describes an outbreak of trichlorfon poisoning in goats from the State University of Maringá, campus Umuarama/PR that received orally the therapeutic dose of the active ingredient in question (100mg/kg). Fifty-three sheep had been treated with the same formulation/solution and no side effects were observed in any of these sheep medicated with triclorfon. But from 20 goats medicated with trichlorfon, eight goats showed, about 40 minutes after its administration, the classic clinical signs of ataxia, external lateral decubitus, drooling, tremors, constricted pupils, noisy dyspnea, involuntary urination and defecation, spastic paresis, bloat and tearing. Almost immediately after the detection of these signals, eight goats were medicated with 1% atropine sulfate (0.5mg/kg and fluid). Five of these goats received a second dose of atropine sulfate one hour after the first application because of some clinical signs such as muscle tremor still being present. Forty-eight to 72 hours after administration of trichlorfon, three of those five goats died. At necropsy we observed cyanotic mucous membranes, congestion of liver, spleen, kidneys and mesenteric vessels, filled gallbladder, emphysema, and reddish lungs. The results of this study call attention to the outbreak that occurred in adult goats in good clinical conditions and, above all, that they received the therapeutic dosage recommended on the manufacture label. This suggests a higher sensitivity of the species to the recommended dose of trichlorfon (100mg/kg) for goats.

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