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Abstract This study aimed to assess the influence of streptozotocin (STZ)-induced diabetes on the nociceptive behavior evoked by the injection of hypertonic saline (HS) into the masseter muscle of rats. Forty male rats were equally divided into four groups: a) isotonic saline control, which received 0.9% isotonic saline (IS), (Ctrl-IS); b) hypertonic saline control, which received 5% HS (Ctrl-HS); c) STZ-induced diabetic, which received IS, (STZ-IS); d) STZ-induced diabetic, which received HS (STZ-HS). Experimental diabetes was induced by a single intraperitoneal injection of STZ at dose of 60 mg/kg dissolved in 0.1 M citrate buffer, and 100 μL of HS or IS were injected into the left masseter to measure the nociceptive behavior. Later on, muscle RNA was extracted to measure the relative expression of the following cytokines: cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF-α), and interleukins (IL)-1β, -2, -6, and -10. One-way analysis of variance (ANOVA) was applied to the data (p < 0.050). We observed a main effect of group on the nociceptive response (ANOVA: F = 11.60, p < 0.001), where the Ctrl-HS group presented the highest response (p < 0.001). However, nociceptive response was similar among the Ctrl-IS, STZ-IS, and STZ-HS group (p > 0.050). In addition, the highest relative gene expression of TNF-α and IL-6 was found in the masseter of control rats following experimental muscle pain (p < 0.050). In conclusion, the loss of somatosensory function can be observed in deep orofacial tissues of STZ-induced diabetic rats. STZinduced (HS groups 09 0 9 0.9 , (IS) CtrlIS Ctrl (Ctrl-IS) b 5 CtrlHS (Ctrl-HS) c STZIS (STZ-IS) d STZHS. STZHS . (STZ-HS) 6 mgkg mg kg 01 1 0. buffer 10 cytokines cyclooxygenase2 cyclooxygenase 2 cyclooxygenase- COX2, COX2 COX (COX-2) TNFα, TNFα TNF α (TNF-α) IL1β, IL1β ILβ IL 1β, 1β β (IL)-1β 2, -2 6, -6 10. -10 Oneway One way ANOVA (ANOVA 0.050. 0050 0.050 050 0.050) 1160 11 11.60 0.001, 0001 0.001 001 0.001) 0.001. However CtrlIS, Ctrl-IS STZIS, STZ-IS addition IL6 IL- conclusion (IS (Ctrl-IS (Ctrl-HS (STZ-IS (STZ-HS (COX-2 (TNF-α - -1 005 0.05 05 116 11.6 000 0.00 00 (COX- 0.0 11. (COX

https://doi.org/10.1590/1807-3107bor-2024.vol38.0073

Leishmania (Sauroleishmania) tarentolae versus pathogenic species: comparative evaluation of protease activity, glycoconjugates, resistance to complement and metabolome composition Sauroleishmania (Sauroleishmania species activity glycoconjugates
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Andrade, Filipe Fideles Duarte

; Vitório, Jéssica Gardone

; Canuto, Gisele André Baptista

; Nunes, Fernanda Freire Campos

; Rodrigues, Isabela Aurora

; Almeida, Ana Paula Martins Morais

; Nascimento, Frederico Crepaldi

; Costa, Adriana Oliveira

; Vieira, Tamara da Silva

; Silva, Ana Carolina Carvalho

; André, Leiliane Coelho

; Gontijo, Célia Maria Ferreira

; Junqueira, Caroline

; Toledo, Juliano Simões de

; Fernandes, Ana Paula

; Soares, Rodrigo Pedro

Memórias do Instituto Oswaldo Cruz

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2024, Volume 119 elocation e230243

Abstract: En | Text: En | PDF: En

BACKGROUND Leishmania tarentolae is a non-pathogenic species found in lizards representing an important model for Leishmania biology. However, several aspects of this Sauroleishmania remain unknown to explain its low level of virulence. OBJECTIVES We reported several aspects of L. tarentolae biology including glycoconjugates, proteolytic activities and metabolome composition in comparison to pathogenic species (Leishmania amazonensis, Leishmania braziliensis, Leishmania infantum and Leishmania major). METHODS Parasites were cultured for extraction and purification of lipophosphoglycan (LPG), immunofluorescence probing with anti-gp63 and resistance against complement. Parasite extracts were also tested for proteases activity and metabolome composition. FINDINGS Leishmania tarentolae does not express LPG on its surface. It expresses gp63 at lower levels compared to pathogenic species and, is highly sensitive to complement-mediated lysis. This species also lacks intracellular/extracellular activities of proteolytic enzymes. It has metabolic differences with pathogenic species, exhibiting a lower abundance of metabolites including ABC transporters, biosynthesis of unsaturated fatty acids and steroids, TCA cycle, glycine/serine/threonine metabolism, glyoxylate/dicarboxylate metabolism and pentose-phosphate pathways. MAIN CONCLUSIONS The non-pathogenic phenotype of L. tarentolae is associated with alterations in several biochemical and molecular features. This reinforces the need of comparative studies between pathogenic and non-pathogenic species to elucidate the molecular mechanisms of virulence during host-parasite interactions. nonpathogenic non However L glycoconjugates amazonensis braziliensis major. major . major) LPG, , (LPG) antigp63 antigp anti gp anti-gp6 complement surface gp6 complementmediated mediated lysis intracellularextracellular intracellular extracellular enzymes transporters steroids cycle glycineserinethreonine glycine serine threonine glyoxylatedicarboxylate glyoxylate dicarboxylate pentosephosphate pentose phosphate pathways features hostparasite host parasite interactions (LPG antigp6 anti-gp

https://doi.org/10.1590/0074-02760230243

Análise do desempenho dos serviços de saúde em um grupo de municípios vulneráveis
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Carvalho, Carolina de Campos

; Viacava, Francisco

; Oliveira, Ricardo Antunes Dantas de

; Martins, Mônica

Ciência & Saúde Coletiva

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2024, Volume 29 N. 7 elocation e03202024

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Estudo descritivo que analisou o desempenho dos serviços de saúde de um grupo de 112 municípios denominado g100 caracterizado por mais de 80 mil habitantes, baixa receita pública e vulnerabilidade socioeconômica. Do Projeto de Avaliação de Desempenho do Sistema de Saúde, foram selecionados 31 indicadores de financiamento, recursos, acesso, efetividade, aceitabilidade e adequação, para o período 2017-2020, e comparadas variações de cada ano em relação ao anterior. Em 2020, houve aumento no aporte financeiro, especialmente por transferências SUS (31,6%). A disponibilidade de leitos vinha decaindo entre 2017 e 2019, aumentou em 2020 e a oferta de profissionais de saúde apresentou leve aumento. Houve redução nos exames de rastreamento de câncer de colo do útero e mama de quase 40% (2020), e reduções de internações cirúrgicas, como cataratas e angioplastias. O percentual de internações por condições sensíveis à atenção primária foi 15,8% em 2020, 14,1% menor do que em 2019. Houve aumento de 55,8% na mortalidade por diabetes e maior abandono do tratamento de tuberculose. O contexto pandêmico exige cautela na interpretação de resultados, que apontam para barreiras de acesso e postergação na prestação de cuidados. 11 g g10 8 habitantes socioeconômica Saúde 3 financiamento recursos efetividade adequação 20172020, 20172020 2017-2020 anterior financeiro 31,6%. 316 31,6% . 6 (31,6%) 201 2019 202 40 , (2020) cirúrgicas angioplastias 158 15 15,8 141 14 1 14,1 558 55 55,8 tuberculose resultados cuidados g1 2017202 2017-202 31,6 (31,6% 20 4 (2020 15, 14, 5 55, 201720 2017-20 31, (31,6 2 (202 20172 2017-2 (31, (20 2017- (31 (2 (3 (

Abstract This work was a descriptive study that analyzed the performance of health services in 112 municipalities (g100) characterized by more than 80,000 inhabitants, low public revenue, and socioeconomic vulnerability. Based on the Projeto de Avaliação de Desempenho do Sistema de Saúde, 31 indicators of funding, resources, access, effectiveness, acceptability, and appropriateness were selected for the period of 2017-2020, and were compared to the variations of each year’s indicators year on year. In 2020, an increase in funding, especially SUS transfers (31.6%), was observed. The availability of hospital beds had been decreasing between 2017 and 2019, but began to increase again in 2020; likewise, the availability of health professionals also showed a slight increase. A decline was observed in cervical and breast cancer screening exams of nearly 40% (2020), as well as a decrease in surgical procedures, such as cataracts and angioplasties. The hospitalizations due to conditions manageable by primary care were 15.8% in 2020, 14.1% lower than in 2019. A 55.8% increase in mortality due to diabetes and greater tuberculosis treatment non-adherence was also observed. The pandemic context calls for caution when interpreting results, which highlight access barriers and postponements of proper health care. 11 g100 g (g100 80000 80 000 80,00 inhabitants revenue vulnerability Saúde 3 funding resources effectiveness acceptability 20172020, 20172020 2020 2017-2020 years s 31.6%, 316 31.6% , 6 (31.6%) 201 2019 likewise 40 (2020) procedures angioplasties 158 15 8 15.8 141 14 1 14.1 558 55 55.8 nonadherence non adherence results g10 (g10 8000 00 80,0 2017202 202 2017-202 31.6 (31.6% 20 4 (2020 15. 14. 5 55. g1 (g1 800 0 80, 201720 2017-20 31. (31.6 2 (202 (g 20172 2017-2 (31. (20 2017- (31 (2 (3 (

https://doi.org/10.1590/1413-81232024297.03202024

The new era of artificial intelligence in neuroradiology: current research and promising tools neuroradiology
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Macruz, Fabíola Bezerra de Carvalho

; Dias, Ana Luiza Mandetta Pettengil

; Andrade, Celi Santos

; Nucci, Mariana Penteado

; Rimkus, Carolina de Medeiros

; Lucato, Leandro Tavares

; Rocha, Antônio José da

; Kitamura, Felipe Campos

Arquivos de Neuro-Psiquiatria

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2024, Volume 82 N. 6 elocation s00441779486

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A radiologia tem uma série de características que a torna uma disciplina médica especialmente adequada à adoção precoce da inteligência artificial (IA), incluindo um fluxo de trabalho digital bem estabelecido, protocolos padronizados para armazenamento de imagens e inúmeras atividades interpretativas bem definidas. Tal adequação é corroborada pelos mais de 200 produtos radiológicos comerciais baseados em IA recentemente aprovados pelo Food and Drug Administration (FDA) para auxiliar os radiologistas em uma série de tarefas restritas de análise de imagens, como quantificação, triagem de fluxo de trabalho e aprimoramento da qualidade das imagens. Entretanto, para o aumento da eficácia e eficiência da IA, além de uma utilização clínica bem-sucedida dos produtos que utilizam essa tecnologia, os radiologistas devem estar atualizados com as aplicações em suas áreas específicas de atuação. Assim, neste artigo, pesquisamos na literatura existente aplicações baseadas em IA em neurorradiologia, mais especificamente em condições como doenças vasculares, epilepsia, condições desmielinizantes e neurodegenerativas. Também abordamos os principais algoritmos por trás de tais aplicações, discutimos alguns dos desafios na generalização no uso desses modelos e introduzimos as soluções comercialmente disponíveis mais relevantes adotadas na prática clínica. Se cautelosamente desenvolvidos, os algoritmos de IA têm o potencial de melhorar radicalmente a radiologia, aperfeiçoando a análise de imagens, aumentando o valor das técnicas de imagem quantitativas e mitigando erros de diagnóstico. , (IA) estabelecido definidas 20 FDA (FDA quantificação Entretanto bemsucedida sucedida tecnologia atuação Assim artigo neurorradiologia vasculares epilepsia neurodegenerativas desenvolvidos diagnóstico (IA 2

Abstract Radiology has a number of characteristics that make it an especially suitable medical discipline for early artificial intelligence (AI) adoption. These include having a well-established digital workflow, standardized protocols for image storage, and numerous well-defined interpretive activities. The more than 200 commercial radiologic AI-based products recently approved by the Food and Drug Administration (FDA) to assist radiologists in a number of narrow image-analysis tasks such as image enhancement, workflow triage, and quantification, corroborate this observation. However, in order to leverage AI to boost efficacy and efficiency, and to overcome substantial obstacles to widespread successful clinical use of these products, radiologists should become familiarized with the emerging applications in their particular areas of expertise. In light of this, in this article we survey the existing literature on the application of AI-based techniques in neuroradiology, focusing on conditions such as vascular diseases, epilepsy, and demyelinating and neurodegenerative conditions. We also introduce some of the algorithms behind the applications, briefly discuss a few of the challenges of generalization in the use of AI models in neuroradiology, and skate over the most relevant commercially available solutions adopted in clinical practice. If well designed, AI algorithms have the potential to radically improve radiology, strengthening image analysis, enhancing the value of quantitative imaging techniques, and mitigating diagnostic errors. (AI adoption wellestablished established storage welldefined defined activities 20 AIbased based FDA (FDA imageanalysis analysis enhancement triage quantification observation However efficiency expertise neuroradiology diseases epilepsy practice designed radiology errors 2

https://doi.org/10.1055/s-0044-1779486

Análise do desempenho dos serviços de saúde em um grupo de municípios vulneráveis
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Carvalho, Carolina de Campos

; Viacava, Francisco

; Oliveira, Ricardo Antunes Dantas de

; Martins, Mônica

Ciência & Saúde Coletiva

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2024, Volume 29 N. 7 elocation e03202024

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/1413-81232024297.03202024

Antimicrobial effect of phytosphingosine in acrylic resin
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Pejon, Luiza Sanchez

; Oliveira, Viviane de Cássia

; Amorim, Ayodele Alves

; Raffaini, Júlia Correa

; Arruda, Carolina Noronha Ferraz de

; Pires-de-Souza, Fernanda de Carvalho Panzeri

Brazilian Dental Journal

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aug 2023, Volume 34 N. 4 Pages 107 - 114

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract This study evaluated color stability (CS), anti-adherence effect (AAE), and cell viability of microorganisms on acrylic resin (AR) surface, treated associated or not with sodium percarbonate (SP). AR specimens were prepared, and color analysis was performed before and after the treatments and the CS was calculated. For analysis of AAE, the samples were sterilized by radiation in a microwave oven. Then samples were randomly distributed: phosphate-buffered saline (PBS - control), 0.5% sodium hypochlorite (SH), phytosphingosine (PHS), and phytosphingosine + SP (PHS+Na2CO3). The specimens remained in contact with solutions for 30 minutes and were later contaminated by Candida albicans. Aliquots were seeded in Petri dishes with Sabouraud Dextrose agar and incubated at 37°C for 24 hours. After the incubation, the number of colonies was counted. The cell viability of adhered microorganisms on the AR was evaluated and 20 fields were observed under an epifluorescence microscope, and the percentage of adhered viable cells was calculated. Data were compared (One-way ANOVA, Tukey, p<.05). As for CS, PHS+ Na2CO3 (0.4±0.1) resulted in less change than PBS (0.9±0.2), similar to the other groups (SH [1.0±0.3)]; PHS [0.9±0.2)]). There was no difference for all tested solutions regarding the ability to avoid microorganism adherence (p>0.05), but PHS (11.2±4.1) resulted in a smaller area of adhered viable cells, statistically different from SH (18.2±7.6) and PBS (26.4±10.8). It was concluded that PHS resulted in lower adhered viable cells and when associated with Na2CO3, also shows a lower effect on the CS of AR. , (CS) antiadherence anti AAE (AAE) (AR surface SP. . (SP) prepared calculated oven distributed phosphatebuffered phosphate buffered control, control control) 05 0 5 0.5 SH, (SH) PHS, (PHS) PHS+Na2CO3. PHSNa2CO3 PHSNaCO PHS+Na2CO3 Na CO (PHS+Na2CO3) 3 albicans 37C C 37 2 hours incubation counted microscope Oneway One way ANOVA Tukey p<.05. p05 p p<.05 p<.05) NaCO Na2CO 0.4±0.1 0401 4 1 (0.4±0.1 0.9±0.2, 0902 0.9±0.2 9 (0.9±0.2) 1.0±0.3 1003 [1.0±0.3)] 0.9±0.2. [0.9±0.2)]) p>0.05, p005 p>0.05 (p>0.05) 11.2±4.1 11241 11 (11.2±4.1 18.2±7.6 18276 18 7 6 (18.2±7.6 26.4±10.8. 264108 26.4±10.8 26 10 8 (26.4±10.8) (CS (AAE (SP 0. (PHS PHSNa PHSNa2CO PHS+Na2CO (PHS+Na2CO3 p0 p<.0 0.4±0. 040 (0.4±0. 090 0.9±0. (0.9±0.2 1.0±0. 100 [1.0±0.3) [0.9±0.2)] p00 p>0.0 (p>0.05 11.2±4. 1124 (11.2±4. 18.2±7. 1827 (18.2±7. 26410 26.4±10. (26.4±10.8 (PHS+Na2CO p<. 0.4±0 04 (0.4±0 09 0.9±0 (0.9±0. 1.0±0 [1.0±0.3 [0.9±0.2) p>0. (p>0.0 11.2±4 112 (11.2±4 18.2±7 182 (18.2±7 2641 26.4±10 (26.4±10. p< 0.4± (0.4± 0.9± (0.9±0 1.0± [1.0±0. [0.9±0.2 p>0 (p>0. 11.2± (11.2± 18.2± (18.2± 264 26.4±1 (26.4±10 0.4 (0.4 0.9 (0.9± 1.0 [1.0±0 [0.9±0. p> (p>0 11.2 (11.2 18.2 (18.2 26.4± (26.4±1 (0. (0.9 1. [1.0± [0.9±0 (p> 11. (11. 18. (18. 26.4 (26.4± (0 [1.0 [0.9± (p (11 (18 26. (26.4 ( [1. [0.9 (1 (26. [1 [0. (26 [ [0 (2

Resumo Este estudo avaliou estabilidade de cor (EC), efeito antiaderente (EAA) e viabilidade celular de microrganismos em superfície de resina acrílica (RA), tratada com solução de fitoesfingosina, associada ou não ao percarbonato de sódio (PS). Espécimes RA foram preparados e análise de cor foi realizada antes e após os tratamentos e EC foi calculada. Para análise de EAA, as amostras foram esterilizadas por radiação em forno de micro-ondas. Então foram distribuídas aleatoriamente: solução salina tamponada com fosfato (PBS - controle), hipoclorito de sódio 0,5% (SH), fitoesfingosina (PHS) e fitoesfingosina + SP (PHS+Na2CO3). Os espécimes permaneceram em contato com as soluções por 30 minutos e posteriormente foram contaminados por Candida albicans. Alíquotas foram semeadas em placas de Petri com ágar Sabouraud Dextrose e incubadas a 37°C por 24 horas. Após a incubação, o número de colônias foi contado. A viabilidade celular dos microorganismos aderidos na RA foi avaliada e 20 campos foram observados em microscópio de epifluorescência, e a porcentagem de células viáveis aderidas foi calculada. Os dados foram comparados (One-way ANOVA, Tukey, p<0,05). Quanto a EC, o PHS+ Na2CO3 [0,4 (0,1)] resultou em menor alteração que o PBS [0,9 (0,2)], semelhante aos demais grupos (SH [1,0 (0,3)]; PHS [0,9 (0,2)]). Não houve diferença para todas as soluções testadas quanto à capacidade de evitar a aderência de microorganismos (p>0,05), mas o PHS [11,2 (4,1)] resultou em uma área menor de células viáveis aderidas, estatisticamente diferente do SH [18,2 (7,6)] e PBS [26,4 (10,8)]. Concluiu-se que o PHS resultou em menor número de células viáveis aderidas e, quando associado ao Na2CO3, também apresenta menor efeito sobre o EC da RA. , (EC) EAA (EAA RA, (RA) PS. PS . (PS) calculada microondas. microondas micro ondas. ondas micro-ondas aleatoriamente controle, controle controle) 05 0 5 0,5 SH, (SH) (PHS PHS+Na2CO3. PHSNa2CO3 PHSNaCO PHS+Na2CO3 Na CO (PHS+Na2CO3) 3 albicans 37C C 37 2 horas incubação contado epifluorescência Oneway One way ANOVA Tukey p<0,05. p005 p p<0,05 p<0,05) NaCO Na2CO 0,4 04 4 [0, 0,1 01 1 (0,1) 0,9 09 9 0,2, 02 0,2 (0,2)] 1,0 10 [1, 0,3 03 (0,3)] 0,2. (0,2)]) p>0,05, p>0,05 (p>0,05) 11,2 112 11 [11, 4,1 41 (4,1) 18,2 182 18 [18, 7,6 76 7 6 (7,6) 26,4 264 26 [26, 10,8. 108 10,8 8 (10,8)] Concluiuse Concluiu se (EC (RA (PS 0, PHSNa PHSNa2CO PHS+Na2CO (PHS+Na2CO3 p00 p<0,0 [0 (0,1 (0,2) 1, [1 (0,3) p>0,0 (p>0,05 11, [11 4, (4,1 18, [18 7, (7,6 26, [26 10, (10,8) (PHS+Na2CO p0 p<0, [ (0, (0,2 (0,3 p>0, (p>0,0 (4, (7, [2 (10,8 p<0 (0 p>0 (p>0, (4 (7 (10, p< ( p> (p>0 (10 (p> (1 (p

https://doi.org/10.1590/0103-6440202305357

The effect of Phytosphingosine and bioactive glass-ceramics in preventing dental enamel erosion glassceramics glass ceramics
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Araujo, Leticia Campos de

; Amorim, Ayodele Alves

; Vivanco, Rocio Geng

; Arruda, Carolina Noronha Ferraz de

; Bikker, Floris J

; Pires-de-Souza, Fernanda de Carvalho Panzeri

Brazilian Dental Journal

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mar 2023, Volume 34 N. 2 Pages 88 - 96

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract This study evaluated the effect of phytosphingosine (PHS) and bioactive glass-ceramic (Biosilicate) on dental enamel in terms of color alteration (ΔE), microhardness, and surface roughness when submitted to erosive challenge (EC). Sixty specimens of bovine teeth (6×6×2mm) were obtained. Initial color (Easyshade, VITA), KHN (HMV-2, Shimadzu), and Ra (SJ-201P, Mitutoyo) measurements were performed. Specimens were separated into groups according to treatments: PHS, 10% Biosilicate, PHS+10% Biosilicate, and artificial saliva (control) and submitted to EC with Coca-Cola for 2 min. This cycle was repeated 4 times daily/15 days. Between cycles, specimens remained in artificial saliva (2 h/37°C). After daily cycles, they were also stored in artificial saliva at 37ºC. Final color, microhardness, and surface roughness measurements were done. Color and KHN data were analyzed by one-way ANOVA, Tukey’s test; and Ra, by 2-way ANOVA, repeated measures, and Tukey’s test (p<.05). The highest ΔE occurred in Saliva+EC (p<.05). Groups treated with PHS presented lower color change than Saliva+EC (p<.05). All the groups presented mean values above the 50:50% perceptibility (50:50%PT) and acceptability (50:50%AT) thresholds, except for control that showed mean value above 50:50%PT but below 50:50%AT. Biosilicate+EC showed higher relative microhardness than Saliva+EC (p<.05), but was similar to PHS+EC and PHS+Biosilicate+EC. Final enamel surface roughness increased for all the groups (p<.05), except for the control. The Biosilicate may prevent enamel mineral loss induced by erosion better than saliva. The PHS associated or not to Biosilicate demonstrated better color stability than saliva. (PHS glassceramic glass ceramic (Biosilicate ΔE, , (ΔE) EC. . (EC) 6×6×2mm 662mm mm 6 2mm (6×6×2mm obtained Easyshade, Easyshade (Easyshade VITA, VITA VITA) HMV2, HMV2 HMV 2, (HMV-2 Shimadzu, Shimadzu Shimadzu) SJ201P, SJ201P SJP SJ 201P, 201P P (SJ-201P Mitutoyo performed treatments 10 PHS10 PHS+10 (control CocaCola Coca Cola min daily15 15 daily/1 days cycles ( h/37°C. h37C hC h/37°C h 37 C h/37°C) 37ºC ºC done oneway one way ANOVA Tukeys Tukey s 2way measures p<.05. p05 p p<.05 05 (p<.05) SalivaEC Saliva 5050% 5050 50 50% 50:50 5050%PT 5050PT PT 50%PT (50:50%PT 5050%AT 5050AT AT 50%AT (50:50%AT thresholds 5050%AT. 50%AT. 50:50%AT BiosilicateEC p<.05, PHSEC PHSBiosilicateEC PHS+Biosilicate+EC (ΔE (EC (HMV- 1 PHS1 PHS+1 daily1 daily/ 3 p0 p<.0 0 (p<.05 505 5 50:5 50PT 50AT (HMV PHS+ p<. (p<.0 50: p< (p<. (p< (p

Resumo Este estudo avaliou o efeito da Fitoesfingosina (PHS) e da vitrocerâmica bioativa (Biosilicato) sobre o esmalte dental em termos de alteração de cor (ΔE), microdureza (KHN) e rugosidade superficial, quando submetido a desafio erosivo (DE). Sessenta espécimes de dentes bovinos (6×6×2mm) foram obtidos. Foram realizadas leituras de cor inicial (Easyshade, VITA), microdureza (HMV-2, Shimadzu) e rugosidade superfícial (SJ-201P, Mitutoyo). Os espécimes foram separados em grupos de acordo com os tratamentos: PHS, Biosilicato a 10%, PHS+Biosilicato a 10%, e saliva artificial (controle). Em seguida, foram submetidos a DE com Coca-Cola por 2 min. Esse ciclo foi repetido 4 vezes/dia por 15 dias. Entre os ciclos, as amostras foram mantidas em saliva artificial (2 h/37°C). Após os ciclos diários, os espécimes também foram armazenados em saliva artificial a 37ºC. Foram realizadas leituras finais de cor, microdureza e rugosidade superficial. Os dados de cor e microdureza foram analisados por ANOVA de uma via, teste de Tukey; e dados de rugosidade superficial, por ANOVA de duas vias, teste de Tukey (p<.05). A maior ΔE ocorreu em Saliva+DE (p<.05). Grupos tratados com PHS apresentaram menor alteração de cor do que Saliva+DE (p<.05). Biosilicate+DE demonstrou valores intermediários, similar (p>.05) aos outros grupos, exceto Saliva+DE. Todos os grupos presentaram média acima dos limites 50:50% de perceptibilidade (50:50%LP) e aceitabilidade (50:50%LA) exceto o controle que demonstrou média acima do 50:50%LA mas abaixo do 50:50%LP. Biosilicate+DE mostrou maior microdureza realativa do que Saliva+DE (p<.05), mas similar a PHS+DE e PHS+Biosilicato+DE. A rugosidade de superfície do esmalte aumentou para todos os grupos, exceto para o controle que presentou a menor alteração (p<.05). O Biosilicato apode prevenir perda mineral do esmalte indizido pela erosão melhor que a saliva. O PHS associado ou não ao Biosilicato demonstrou melhor estabilidade de cor que a saliva. (PHS (Biosilicato ΔE, , (ΔE) KHN (KHN superficial DE. . (DE) 6×6×2mm 662mm mm 6 2mm (6×6×2mm obtidos Easyshade, Easyshade (Easyshade VITA, VITA VITA) HMV2, HMV2 HMV 2, (HMV-2 Shimadzu SJ201P, SJ201P SJP SJ 201P, 201P P (SJ-201P Mitutoyo. Mitutoyo Mitutoyo) tratamentos 10 10% PHSBiosilicato controle. (controle) seguida CocaCola Coca Cola min vezesdia vezes dia 1 dias ( h/37°C. h37C hC h/37°C h 37 C h/37°C) diários 37ºC ºC via vias p<.05. p05 p p<.05 05 (p<.05) SalivaDE Saliva BiosilicateDE Biosilicate intermediários p>.05 (p>.05 5050% 5050 50 50% 50:50 5050%LP 5050LP LP 50%LP (50:50%LP 5050%LA 5050LA LA 50%LA (50:50%LA 5050%LP. 50%LP. 50:50%LP p<.05, PHSDE PHSBiosilicatoDE PHS+Biosilicato+DE (ΔE (DE (HMV- (controle 3 p0 p<.0 0 (p<.05 p>.0 (p>.0 505 5 50:5 50LP 50LA (HMV p<. (p<.0 p>. (p>. 50: p< (p<. p> (p> (p< (p

https://doi.org/10.1590/0103-6440202304904

Análise comparativa de classificações de vulnerabilidade para municípios g100 g g10 g1
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Carvalho, Carolina de Campos

; Martins, Mônica

; Viacava, Francisco

; Oliveira, Ricardo Antunes Dantas de

Revista Brasileira de Estudos de População

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2023, Volume 40 elocation e0246

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumen En 2009, el Frente Nacional de Alcaldes (FNP) nombró como g100 a un grupo de municipios caracterizados por tener más de ochenta mil habitantes, bajos niveles de ingreso público per cápita y alta vulnerabilidad socioeconómica. Este estudio buscó describir el g100 a partir de la posición comparativa según tres medidas de vulnerabilidad socioeconómica aplicadas a municipios con más de ochenta mil, y a partir de ahí discutir la pertinencia de utilizar la propuesta del FNP como sugerencia de priorización en las políticas sociales. Para ello se comparó la lista de los primeros cien municipios del g100 con los índices de desarrollo humano municipal (HDIM), de vulnerabilidad social (IVS) y brasileño de privación (IBP). Se identificó que 25 municipios clasificados como g100 no estaban clasificados entre los 100 primeros en los demás índices, aunque 46 estuvieron entre los más considerados en las tres medidas. Se discute la necesidad de un amplio debate y consenso sobre las medidas de vulnerabilidad socioeconómica utilizadas en la planificación y ejecución de políticas públicas. Esta reflexión se ancla en la defensa de que las acciones y políticas públicas se inician intrínsecamente para garantizar una mayor equidad geográfica y distributiva frente a la obediencia para responder a las demandas de la población. 2009 (FNP g g10 habitantes sociales HDIM, HDIM , (HDIM) IVS (IVS IBP. IBP . (IBP) 2 10 4 población 200 g1 (HDIM (IBP 1 20

Abstract In 2009, the Frente Nacional de Prefeitos (FNP) named a group of municipalities with more than 80,000 inhabitants, low levels of public revenue per capita and high socioeconomic vulnerability g100. This study sought to describe the g100 from the comparative position according to three measures of socioeconomic vulnerability applied to municipalities with more than 80,000 inhabitants, and to discuss the pertinence of using the FNP proposal as a suggestion for prioritization in social policies. Comparing the list of the first 100 g100 municipalities with the indices: Municipal Human Development Index (HDIM), Social Vulnerability Index (IVS) and Brazilian Deprivation Index (IBP), we identified 25 municipalities classified as g100 that were not classified among the top 100 in the other indices; but 46 g100 counties were among the most considered in all three measures. The need for broad debate and consensus on measures of socioeconomic vulnerability used in the planning and execution of public policies is discussed. This reflection is based on the belief that public actions and policies are intrinsically implemented to guarantee greater geographic and allocative equity in order to respond to the demands of the population. 2009 (FNP 80000 80 000 80,00 inhabitants g g10 10 indices HDIM, HDIM , (HDIM) IVS (IVS IBP, IBP (IBP) 2 4 discussed population 200 8000 8 00 80,0 g1 1 (HDIM (IBP 20 800 0 80,

Resumo Em 2009, a Frente Nacional de Prefeitos (FNP) denominou g100 um grupo de municípios caracterizados por possuir mais de 80 mil habitantes, baixos níveis de receita pública per capita e alta vulnerabilidade socioeconômica. Este estudo buscou descrever o g100 a partir da posição comparativa segundo três medidas de vulnerabilidade socioeconômica aplicadas aos municípios com mais de 80 mil habitantes, discutindo a pertinência do uso da proposta da FNP como critério de priorização em políticas sociais. Comparou-se a listagem dos 100 primeiros municípios g100 com aquelas do Índice do Desenvolvimento Humano Municipal (IDHM), Índice de Vulnerabilidade Social (IVS) e Índice Brasileiro de Privação (IBP). Identificou-se que 25 municípios classificados como g100 não estavam entre os 100 primeiros nos demais índices; mas 46 municípios g100 encontravam-se entre os mais vulneráveis nas três medidas. Discute-se a necessidade de amplo debate e consenso sobre as medidas de vulnerabilidade socioeconômica empregadas no planejamento e execução de políticas públicas. Esta reflexão está ancorada na defesa de que as ações e políticas públicas sejam intrinsicamente planejadas para garantia de maior equidade geográfica e alocativa em face da efetividade de resposta às demandas da população. 2009 (FNP g g10 8 habitantes sociais Comparouse Comparou se 10 IDHM, IDHM , (IDHM) IVS (IVS IBP. IBP . (IBP) Identificouse Identificou 2 índices 4 encontravamse encontravam Discutese Discute população 200 g1 1 (IDHM (IBP 20

https://doi.org/10.20947/s0102-3098a0246

Pandemia da Covid-19: variação no uso de internações hospitalares nos municípios g100 Covid19 Covid 19 Covid-19 g g10 Covid1 1 Covid-1 g1 Covid-
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Carvalho, Carolina de Campos

; Martins, Mônica

; Viacava, Francisco

; Peixoto, Caio de Paula

; Romão, Anselmo Rocha

; Oliveira, Ricardo Antunes Dantas de

Saúde em Debate

Journal Metrics
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dec 2022, Volume 46 N. spe8 Pages 89 - 105

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT This study aims to comparatively analyze the volume and flows for hospital admissions before and during the first year of the COVID-19 pandemic in 112 g100 municipalities, which are characterized by having more than 80,000 inhabitants, low income, and high socioeconomic vulnerability. Data from the SUS Hospital Information System regarding hospitalizations of adults (age ≥ 18 years) in the period 2017-2020. Hospitalizations were classified according to type of admission or specialty of treatment in the following categories: elective, urgency/emergency, clinical, surgical, obstetric, and oncological treatment. Elective hospitalizations showed a greater reduction in volume in 2020 compared to the previous year, probably due to the measures adopted to minimize the risks of contagion and prioritization of care to severe patients by COVID-19. Considering the place of hospitalization, no significant changes were observed in relation to the referral of residents of g100 municipalities to other municipalities. However, there was differentiation between localities in which regionalization in health works in a more appropriate way, and others where there is a scarcity of resources or need for more effective planning and management. COVID19 COVID 19 COVID-1 11 g g10 80000 80 000 80,00 inhabitants income vulnerability age 1 years 20172020. 20172020 2017 2020. 2017-2020 categories elective urgencyemergency urgency emergency urgency/emergency clinical surgical obstetric 202 COVID19. 19. hospitalization However way management COVID1 COVID- g1 8000 8 00 80,0 2017202 201 2017-202 20 800 0 80, 201720 2017-20 2 20172 2017-2 2017-

RESUMO Este estudo objetivou analisar comparativamente o volume e os fluxos para internações hospitalares antes e durante o primeiro ano da pandemia da Covid-19 nos 112 municípios g100. Esses municípios caracterizam-se por ter mais de 80 mil habitantes, baixa renda e alta vulnerabilidade socioeconômica. Foram utilizados dados do Sistema de Informações Hospitalares do Sistema Único de Saúde referentes ao período 2017-2020. Selecionaram-se as internações de adultos (idade ≥ 18 anos), que foram classificadas segundo tipo de admissão ou especialidade do tratamento nas seguintes categorias: eletivas ou urgência/ emergência; tratamento clínico, cirúrgico, obstétrico e oncológico. As internações eletivas apresentaram maior redução no volume em 2020 em relação ao ano anterior devido às medidas adotadas para minimizar os riscos de contágio e priorização do cuidado aos pacientes grave por Covid-19. Não foram observadas alterações significativas em relação ao local de realização das internações de residentes de municípios g100. Contudo, no g100, observou-se diferenciação entre localidades nas quais a regionalização em saúde funciona de forma mais adequada, e em outras onde há escassez de recursos ou necessidade de planejamento e gestão mais efetivos. Covid19 Covid 19 Covid-1 11 g100 g caracterizamse caracterizam se 8 habitantes socioeconômica 20172020. 20172020 2017 2020. 2017-2020 Selecionaramse Selecionaram idade 1 anos, anos , anos) categorias urgência emergência clínico cirúrgico oncológico 202 Covid19. 19. Contudo observouse observou adequada efetivos Covid1 Covid- g10 2017202 201 2017-202 20 g1 201720 2017-20 2 20172 2017-2 2017-

https://doi.org/10.1590/0103-11042022e807

10.

Risk factors of transplant renal artery stenosis in kidney transplant recipients
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Kanhouche, Gabriel

; Santos, Gustavo Rocha Feitosa

; Orellana, Henry Campos

; Galhardo, Attilio

; Faccinetto, Ana Carolina Buso

; Barteczko, Manoela Linhares Machado

; Carvalho, Luiz Sérgio F. de

; Taddeo, Julia Bernardi

; Foresto, Renato Demarchi

; Moises, Valdir Ambrósio

; Tedesco-Silva, Helio

; Pestana, José Medina

; Barbosa, Adriano Henrique Pereira

Clinics

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2022, Volume 77 elocation 100087

Abstract: En | Text: En | PDF: En

Abstract Background: Transplant Renal Artery Stenosis (TRAS) is a recognized vascular complication after kidney transplantation. The overall risk predictors of TRAS are poorly understood. Methods: Retrospective analysis of patients with suspected TRAS (Doppler ultrasound PSV > 200 cm/s) who underwent angiographic study in a single center between 2007 and 2014. All patients with stenosis > 50% were considered with TRAS. Stenosis restricted in the body of the artery was also analyzed in a subgroup. Results: 274 patients were submitted to a renal angiography and 166 confirmed TRAS. TRAS group featured an older population (46.3 ± 11.0 vs. 40.9 ±14.2 years; p = 0.001), more frequent hypertensive nephropathy (30.1% vs. 15.7%; p = 0.01), higher incidence of Delayed Graft Function (DGF) (52.0% vs. 25.6%; p < 0.001) and longer Cold Ischemia Time (CIT) (21.5 ± 10.6 vs. 15.7 ± 12.9h; p < 0.001). In multivariable analyses, DGF (OR = 3.31; 95% CI 1.78-6.30; p < 0.0001) was independent risk factors for TRAS. DM and CIT showed a tendency towards TRAS. The compound discriminatory capacity of the multivariable model (AUC = 0.775; 95% CI 0.718-0.831) is significantly higher than systolic blood pressure and creatinine alone (AUC = 0.62; 95% CI 0.558-0.661). In body artery stenosis subgroup, DGF (OR = 1.86; 95% CI 1.04-3.36; p = 0.03) and Diabetes Mellitus (DM) (OR = 2.44; 95% CI 1.31-4.60; p = 0.005) were independent risk factors for TRAS. Conclusion: In our transplant population, DGF increased more than 3-fold the risk of TRAS. In the subgroup analysis, both DGF and DM increases the risk of body artery stenosis. The addition of other factors to hypertension and renal dysfunction may increase diagnostic accuracy.

https://doi.org/10.1016/j.clinsp.2022.100087

11.

Knowledge, attitudes, and psychosocial impacts among Brazilian Pediatric Dentists during COVID-19 pandemic
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Torres, Carolina Paes

; Lizzi, Elisangela Aparecida da Silva

; Borsatto, Maria Cristina

; Nelson Filho, Paulo

; De Rossi, Andiara

; Díaz-Serrano, Kranya Victoria

; Barros, Aldevina Campos Freitas de

; Paula-Silva, Francisco Wanderley Garcia

; Carvalho, Fabrício Kitazono de

; Silva, Raquel Assed Bezerra

; Silva, Lea Assed Bezerra

; Lucisano, Marília Pacífico

; Queiroz, Alexandra Mussolino

Brazilian Oral Research

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2022, Volume 36 elocation e028

Abstract: En | Text: En | PDF: En

Abstract: In this study, we evaluated the knowledge, attitudes, and psychosocial impacts among Brazilian pediatric dentists during the COVID-19 pandemic. A cross-sectional study with primary data collection was carried out using an online structured questionnaire. Data were submitted to descriptive analysis by using absolute and relative frequencies. A chi-square test was used for association analysis and log-linear regression models to estimate the prevalence ratio (5%). The population comprised mostly women and knowledge regarding COVID-19 was satisfactory (above 80% in most items). N95 masks and faceshields were used, albeit 64.22% reported difficulty in providing dental care to children due to the need for extra Personal Protective Equipment. Thirty eight percent provided urgency/emergency dental care, 59.78% performed invasive procedures, 59.56% used high speed handpieces, 8.44% started using cariostatics, and 6.22% introduced the use of chemomechanical caries removal agents. Fear for the future (PR = 1.21) and use of medications (for anxiety, depression, or insomnia) increased (PR = 1.16) among the ones who had wage losses. Brazilian pediatric dentists have knowledge about COVID-19, and attitudes in their clinical routines changed due the pandemic. Financial life was harmed and a negative impact of the pandemic in psychosocial aspects of workers was found.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0028

12.

Pandemia da Covid-19: variação no uso de internações hospitalares nos municípios g100
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Carvalho, Carolina de Campos

; Martins, Mônica

; Viacava, Francisco

; Peixoto, Caio de Paula

; Romão, Anselmo Rocha

; Oliveira, Ricardo Antunes Dantas de

Saúde em Debate

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2022, Volume 46 N. spe8 Pages 89 - 105

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/0103-11042022e807

13.

Gonadal Differentiation During Embryonic and Fetal Development of Male New Zealand Rabbits (Oryctolagus cuniculus)
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Miranda, Carla Maria Figueiredo de Carvalho

; Leonel, Luciano César Pereira Campos

; Koga, Bruna Andrade Aguiar

; Anunciação, Adriana Raquel de Almeida da

; Mario, Lara Carolina

; Favaron, Phelipe Oliveira

; Martins, Daniele dos Santos

; Vásquez, Bélgica

; Conei, Daniel

; Miglino, Maria Angélica

; del Sol, Mariano

International Journal of Morphology

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oct 2021, Volume 39 N. 5 Pages 1253 - 1263

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

SUMMARY: The rabbit is considered an ideal animal model for studies that describe abnormalities in the testicles due to the similar morphogenetic mechanisms of sexual development and diseases commonly found in humans. The aim of this study was to determine the male sexual differentiation of the New Zealand rabbit (Oryctolagus cuniculus) through development. The gestational age was estimated and classified as 9, 12, 14, 16, 18, 20, 23 and 28 gestational days. The morphological and sexual determination were performed by histological analysis of the reproductive tract in the embryos and fetuses (9-28 days) as well as by immunohistochemistry- Desert hedgehog-Dhh- (testis-specific protein on Y chromosome- 16, 20, 23 days and adult rabbits). Gonads were observed from the 14th day in an undifferentiated stage and with homogeneous aspect. Sexual differentiation was observed from the 16th day with presence of cells forming gonadal cords and Dhh+ cells in the gonadal parenchyma. From the 18th gestational day testicular cords were observed, which evolved into organized seminiferous tubules. The formation of the efferent ducts and ductus deferens and epididymis was observed on the 20th and 23rd days, respectively. The differentiation of the external genitalia occurred from the 23rd days from the anogenital distance and was identified to identify the penile structures. In summary, the features of the sexual differentiation were determined by observation of the Dhh+ protein in embryos from the 16th day to adulthood, and the morphological particularities observed from the 18th gestational day, determined by differentiation of the external genitalia from the 23rd day.

RESUMEN: El conejo se considera un modelo animal ideal para estudios que describen anomalías a nivel testícular debido a que presenta mecanismos morfogenéticos similares al desa- rrollo sexual y enfermedades que se encuentran comúnmente en los seres humanos. El objetivo de este estudio fue determinar la diferenciación sexual masculina del conejo de Nueva Zelanda (Oryctolagus cuniculus) a través del desarrollo. La edad gestacional se estimó y clasificó en 9, 12, 14, 16, 18, 20, 23 y 28 días gestacionales. La determinación morfológica y sexual se realizó mediante análisis histológico del tracto reproductivo en los embriones y fetos (9 - 28 días) así como mediante inmunohistoquímica -Desert hedgehog-Dhh- (proteína testicular específica en el cromosoma Y- 16, 20, 23 días y conejos adultos). Las gónadas se observaron a partir del día 14 en un estadio indiferenciado y con aspecto homogéneo. Se observó diferenciación sexual a partir del día 16 con presencia de células formadoras de cordones gonadales y células Dhh+ en el parénquima gonadal. A partir del día 18 de gestación se observaron cordones testiculares, que evolucionaron a túbulos seminíferos organizados. La formación de los conductos eferentes, deferentes y del epidídimo se observó a los 20 y 23 días, respectivamente. La diferenciación de los genitales externos ocurrió a partir del día 23 desde la distancia anogenital y se utilizó para identificar las estructuras del pene. En conclusión, las características de la diferenciación sexual se determinaron mediante la observación de la proteína Dhh en embriones desde el día 16 hasta la edad adulta, y las particularidades morfológicas observadas a partir del día 18 de gestación, determinadas por diferenciación de los genitales externos a partir del día 23.

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14.

Registro Multicêntrico de Takotsubo (REMUTA) – Aspectos Clínicos, Desfechos Intra-Hospitalares e Mortalidade a Longo Prazo
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Almeida Junior, Gustavo Luiz Gouvêa de

; Mansur Filho, João

; Albuquerque, Denilson Campos de

; Xavier, Sergio Salles

; Pontes, Álvaro

; Gouvêa, Elias Pimentel

; Martins, Alexandre Bahia Barreiras

; Nunes, Nágela S. V.

; Carestiato, Lilian Vieira

; Petriz, João Luiz Fernandes

; Santos, Armando Márcio Gonçalves

; Bandeira, Bruno Santana

; Abufaiad, Bárbara Elaine de Jesus

; Pacheco, Luciana da Camara

; Oliveira, Maurício Sales de

; Ribeiro Filho, Paulo Eduardo Campana

; Sampaio, Pedro Paulo Nogueres

; Duque, Gustavo Salgado

; Camillis, Luiz Felipe

; Marques, André Casarsa

; Lourenço Jr, Francisco Carlos

; Palazzo, José Ricardo

; Costa, Cláudio Ramos da

; Silva, Bibiana Almeida da

; Zukowski, Cleverson Neves

; Garcia, Romulo Ribeiro

; Zonis, Fernanda de Carvalho

; Paula, Suzana Andressa Morais de

; Ferrari, Carolina Gravano Ferraz

; Rangel, Bruno Soares da Silva

; Ferreira, Roberto Muniz

; Mendes, Bárbara Ferreira da Silva

; Castro, Isabela Ribeiro Carvalho de

; Souza, Leonardo Giglio Gonçalves de

; Araújo, Luiz Henrique dos Santos

; Giani, Alexandre

Arquivos Brasileiros de Cardiologia

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aug 2020, Volume 115 N. 2 Pages 207 - 216

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento A síndrome de takotsubo (takotsubo) é uma forma de cardiomiopatia adquirida. Dados nacionais sobre essa condição são escassos. O Registro REMUTA é o primeiro a incluir dados multicêntricos dessa condição no nosso país. Objetivo Descrever as características clínicas, prognóstico, tratamento intra-hospitalar e mortalidade hospitalar e em 1 ano de seguimento. Métodos Estudo observacional, retrospectivo, tipo registro. Incluídos pacientes internados com diagnóstico de takotsubo ou que desenvolveram esta condição durante internação por outra causa. Os desfechos avaliados incluíram fator desencadeador, análise dos exames, uso de medicações, complicações e óbito intra-hospitalar e em 1 ano de seguimento. O nível de significância adotado foi de 5%. Resultados Foram incluídos 169 pacientes, em 12 centros no Estado do Rio de Janeiro. A idade média foi de 70,9 ± 14,1 anos e 90,5% eram do sexo feminino; 63% dos casos foram de takotsubo primário e 37% secundário. Troponina I foi positiva em 92,5% dos pacientes e a mediana de BNP foi de 395 (176,5; 1725). Supradesnivelamento do segmento ST esteve presente em 28% dos pacientes. A fração de ejeção do ventrículo esquerdo teve mediana de 40 (35; 48)%. Observamos taxa de 25,7% de ventilação mecânica invasiva e 17,4% de choque. Suporte circulatório mecânico foi utilizado em 7,7%. A mortalidade intra-hospitalar foi de 10,6% e a mortalidade ao final de 1 ano foi de 16,5%. Takotsubo secundário e choque cardiogênico foram preditores independentes de mortalidade. Conclusão Os resultados do REMUTA mostram que takotsubo não se trata de patologia benigna como se pensava, especialmente no grupo de takotsubo secundário que acarreta elevada taxa de complicações e de mortalidade. (Arq Bras Cardiol. 2020; 115(2):207-216)

Abstract Background Takotsubo syndrome (TTS) is an acquired form of cardiomyopathy. National Brazilian data on this condition are scarce. The Takotsubo Multicenter Registry (REMUTA) is the first to include multicenter data on this condition in Brazil. Objective To describe the clinical characteristics, prognosis, in-hospital treatment, in-hospital mortality, and mortality during 1 year of follow-up. Methods This is an observational, retrospective registry study including patients admitted to the hospital with diagnosis of TTS and patients admitted for other reasons who developed this condition. Evaluated outcomes included triggering factor, analysis of exams, use of medications, complications, in-hospital mortality, and mortality during 1 year of follow-up. A significance level of 5% was adopted. Results The registry included 169 patients from 12 centers in the state of Rio de Janeiro, Brazil. Mean age was 70.9 ± 14.1 years, and 90.5% of patients were female; 63% of cases were primary TTS, and 37% were secondary. Troponin I was positive in 92.5% of patients, and median BNP was 395 (176.5; 1725). ST-segment elevation was present in 28% of patients. Median left ventricular ejection fraction was 40 (35; 48)%. We observed invasive mechanical ventilation in 25.7% of cases and shock in 17.4%. Mechanical circulatory support was used in 7.7%. In-hospital mortality was 10.6%, and mortality at 1 year of follow-up was 16.5%. Secondary TTS and cardiogenic shock were independent predictors of mortality. Conclusion The results of the REMUTA show that TTS is not a benign pathology, as was once thought, especially regarding the secondary TTS group, which has a high rate of complications and mortality. (Arq Bras Cardiol. 2020; 115(2):207-216)

https://doi.org/10.36660/abc.20190166 1217 downloads

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[SciELO Preprints] - The Novel Coronavirus: An Alert for Pacifiers’ Disinfection
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Souza, Vívian Gonçalves Carvalho Lopes, Danielle Fernandes Machado, Fernanda Campos Fabri, Rodrigo Luiz Apolônio, Ana Carolina Morais

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Publication date: 2020-04-24

Abstract: En

Objective: To evaluate the best strategy for pacifier disinfection methods. Material and Methods: The literature search was conducted on MEDLINE/PubMed, Scielo, Lilacs, Web of Science, and Scopus databases to find all relevant articles published over the past 20 years, based on PRISMA guidelines. Two reviewers extracted data independently by using a standardized form. The following factors were recorded: country of study, type of study, pacifier material, sample number, microorganisms analyzed, decontamination methods used, method accessibility and results found. Results: A total of 121 articles were obtained from all databases. The selected documents underwent a final screening, resulting in 8 articles. The method of disinfection analyzed by the literature were: 3.5% neutral detergent, apple cider vinegar 70% spray, boiling water during 15 minutes, sodium hypochlorite 2.5, hydrogen peroxide 70% spray, chlorhexidine 0.12%, Brushtox®, sterile water and microwave. Conclusion: Because of the broad methods for pacifier disinfection and different levels of accessibility to disinfectant agents, the pacifier consensus for decontamination remains unclear. Although the disinfection methods are diverse, the methods suggested to its disinfection were identified and described in this article.

https://doi.org/10.1590/pboci.2020.070

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