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Endothelial dysfunction as a consequence of COVID-19
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Carrera-de la Cruz, Brian

; Orea-Tejeda, Arturo

; González-Islas, Dulce

; Sánchez-Santillán, Rocío

Neumología y cirugía de tórax

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sep 2022, Volume 81 N. 3 Pages 178 - 182

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract: COVID-19 (coronavirus infectious disease 2019) is caused by the virus SARS-CoV-2 and it has been a major health public problem worldwide, with complications and more than a million deaths around the world. The virus is part of the Coronaviridae family, and beta coronavirus (β-CoV) genus. Possess several proteins that codify the RNA and take action in the pathogenesis of the diseases. COVID-19 can occur as an asymptotic disease or with symptoms like cough, shortness of breath, fever, pneumonia, pulmonary edema, severe acute respiratory syndrome (SARS), in some cases neurological and gastrointestinal symptoms, even death. SARS-CoV-2 has several manifestations, in this review, we collect information for most recent articles about gastrointestinal manifestations, endothelial function, and the molecules involved in it, likewise, sepsis and inflammatory disease, and how the virus can act in that disease. SARS-CoV-2 causes endothelial dysfunction by infection and replication in the endothelial cells, additionally, by inflammatory interleukins release. Such as sepsis SARS-CoV-2 causes coagulopathy disorders; platelet aggregation, micro thrombosis, and severe complications, showing in a dimer D increased, and prothrombin time prolongation. Therefore, the aim of this article is to collect recent information available about the effect of SARS-CoV-2 on different organs, mainly gastrointestinal and endothelial function.

Resumen: La COVID-19 (coronavirus infectious disease 2019) es una enfermedad causada por el virus SARS-CoV-2 y ha sido un problema de salud a nivel mundial, con mayor morbilidad y mortalidad. El virus pertenece a la familia Coronaviridae, perteneciente del género betacoronavirus. (β-CoV). Posee proteínas específicas que codifican el RNA viral y toman acción en la patogénesis de la enfermedad. La COVID-19 puede cursar de manera asintomática o presentar los siguientes síntomas: tos, disnea, fiebre, neumonía, edema pulmonar, síndrome de insuficiencia respiratoria aguda (SIRA), en algunos casos síntomas gastrointestinales, neurológicos, incluso la muerte. El virus SARS-CoV-2 tiene diferentes manifestaciones a nivel sistémico, en este artículo se recopila la más reciente información sobre las manifestaciones gastrointestinales, función endotelial y sus moléculas, así como la relación entre el SARS-CoV-2 y la enfermedad inflamatoria y sepsis. El SARS-CoV-2 afecta al endotelio a través de la infección y replicación en las células endoteliales, además de generar una liberación de interleucinas inflamatorias. Así como la sepsis, el virus puede causar trastornos de la coagulación como agregación plaquetaria, microtrombosis y complicaciones más severas, demostradas en el incremento en el dímero D, y tiempos de coagulación prolongados. El objetivo de este estudio es resumir la información actual disponible acerca del SARS-CoV-2 en diferentes órganos y la función endotelial.

https://doi.org/10.35366/111088

Clinical and Epidemiological Characteristics of Patients Diagnosed with COVID-19 in a Tertiary Care Center in Mexico City: A Prospective Cohort Study
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Ortiz-Brizuela, Edgar

; Villanueva-Reza, Marco

; González-Lara, María F.

; Tamez-Torres, Karla M.

; Román-Montes, Carla M.

; Díaz-Mejía, Bruno A.

; Pérez-García, Esteban

; Olivas-Martínez, Antonio

; Rajme-López, Sandra

; Martinez-Guerra, Bernardo A.

; León-Cividanes, Nereyda A. de

; Fernández-García, Oscar A.

; Guerrero-Torres, Lorena

; Torres-González, Lorena

; Carrera-Patiño, Fabián A.

; Corral-Herrera, Ever A.

; Hernández-Alemón, Aldo N.

; Tovar-Vargas, Maria de los Ángeles

; Serrano-Pinto, Yamile G.

; Espejo-Ortiz, Cristian E.

; Morales-Ortega, María de la L.

; Lozano-Cruz, Óscar A.

; Cárdenas-Fragoso, José L.

; Vidal-Mayo, José de J.

; Hernández-Gilsoul, Thierry

; Rivero-Sigarroa, Eduardo

; Domínguez-Cherit, Guillermo

; Cervantes-Villar, Luz E.

; Ramos-Cervantes, Maria del P.

; Ibarra-González, Violeta

; Calva-Mercado, Juan J.

; Sierra-Madero, Juan G.

; López-Íñiguez, Álvaro

; Ochoa-Hein, Eric

; Crabtree-Ramírez, Brenda E.

; Galindo-Fraga, Arturo

; Guerrero-Almeida, María de L.

; Ruiz-Palacios, Guillermo M.

; Gulías-Herrero, Alfonso

; Sifuentes-Osornio, José

; Kershenobich-Stalnikowitz, David

; Ponce-de-León, Alfredo

Revista de investigación clínica

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jun 2020, Volume 72 N. 3 Pages 165 - 177

Abstract: En | Text: En | PDF: En

ABSTRACT Background: Regional information regarding the characteristics of patients with coronavirus disease (COVID)-19 is needed for a better understanding of the pandemic. Objective: The objective of the study to describe the clinical features of COVID-19 patients diagnosed in a tertiary-care center in Mexico City and to assess differences according to the treatment setting (ambulatory vs. hospital) and to the need of intensive care (IC). Methods: We conducted a prospective cohort, including consecutive patients with COVID-19 from February 26, 2020 to April 11, 2020. Results: We identified 309 patients (140 inpatients and 169 outpatients). The median age was 43 years (interquartile range, 33-54), 59.2% men, and 18.6% healthcare workers (12.3% from our center). The median body mass index (BMI) was 29.00 kg/m2 and 39.6% had obesity. Compared to outpatients, inpatients were older, had comorbidities, cough, and dyspnea more frequently. Twenty-nine (20.7%) inpatients required treatment in the IC unit (ICU). History of diabetes (type 1 or 2) and abdominal pain were more common in ICU patients compared to non-ICU patients. ICU patients had higher BMIs, higher respiratory rates, and lower room-air capillary oxygen saturations. ICU patients showed a more severe inflammatory response as assessed by white blood cell count, neutrophil and platelet count, C-reactive protein, ferritin, procalcitonin, and albumin levels. By the end of the study period, 65 inpatients had been discharged because of improvement, 70 continued hospitalized, and five had died. Conclusions: Patients with comorbidities, either middle-age obese or elderly complaining of fever, cough, or dyspnea, were more likely to be admitted. At admission, patients with diabetes, high BMI, and clinical or laboratory findings consistent with a severe inflammatory state were more likely to require IC.

https://doi.org/10.24875/ric.20000211 533 downloads

Habilidades que determinan el éxito del emprendedurismo del sector industrial de la ciudad de Hermosillo, Sonora
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Coronado-García, Manuel Arturo

; Leyva-Carrera, Alma Brenda

; Encinas-Meléndrez, Leticia del Carmen

; Rosetti-López, Sergio Ramón

; Rojas-Rodríguez, Isaac Shamir

Estudios sociales. Revista de alimentación contemporánea y desarrollo regional

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jun 2020, Volume 30 N. 55 elocation e20854

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Objective: This study included the analysis of the perceptions of entrepreneurs in the industrial sector of Hermosillo, Sonora Mexico, regarding the assessment of the skills they develop and apply in their activity. Methodology: 52 entrepreneurs were interviewed and eight skills were evaluated: 1) Creativity, 2) Initiative and responsibility, 3) Planning, 4) Management and commitment, 5) Social responsibility and teamwork 6) Attitude to face change, 7) Self-confidence and 8) Communication. Results: The results showed differences in terms of skill ratings, and their correlation with each other, evidencing that Management and commitment skills have a negative correlation with the rest of the variables. Limitations: The interviewees were reluctant to share information. Conclusions: The group of entrepreneurs studied must become aware of the importance of the ability of Management and commitment in achieving the objectives of the companies, which makes it a challenge or opportunity area for the consolidation of the entrepreneurial profile of the subjects studied.

Resumen Objetivo: El presente estudio comprendió el análisis de las percepciones de los emprendedores del sector industrial de Hermosillo, Sonora México, con respecto a la valoración de las habilidades que desarrolla y aplica en su actividad. Metodología: Se entrevistaron 52 emprendedores y se evaluaron ocho habilidades: 1) Creatividad, 2) Iniciativa y responsabilidad, 3) Planificación, 4) Gestión y compromiso, 5) Responsabilidad social y trabajo en equipo 6) Actitud para enfrentar el cambio, 7) Autoconfianza y 8) Comunicación. Resultados: Los resultados arrojaron diferencias en cuanto a las valoraciones de las habilidades, y su correlación entre sí, evidenciando que la habilidad de Gestión y compromiso tienen una correlación negativa con el resto de las variables. Limitaciones: Las personas entrevistadas se mostraron reticentes al momento de compartir información. Conclusiones: El grupo de emprendedores estudiados debe de cobrar conciencia sobre la importancia de la habilidad de Gestión y compromiso en el logro de los objetivos de las empresas, lo que la convierte en un reto o área de oportunidad para la consolidación del perfil emprendedor de los sujetos estudiados.

https://doi.org/10.24836/es.v30i55.854 135 downloads

New coral reef structures in a tropical coral reef system
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Liaño-Carrera, Francisco

; Camarena-Luhrs, Tomás

; Gómez-Barrero, Arturo

; Martos-Fernández, Francisco Javier

; Ramírez-Macias, José Isaac

; Salas-Monreal, David

Latin american journal of aquatic research

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may 2019, Volume 47 N. 2 Pages 270 - 281

Abstract: En | Text: En | PDF: En

ABSTRACT A multibeam sonar combined with an Acoustic Doppler Current Profiler (ADCP) were used at the Veracruz Reef System (VRS), Gulf of Mexico, during the spawning period of August 2016 in order to elucidate plankton trajectories within the study area. The new high-resolution bathymetry provided the location of 50 coral reefs, 27 more reefs than known at the VRS. Most of those reefs are submerged reefs located at depths greater than 40 m. The total coral reef area of the VRS was calculated in 70.1557 km2. Only ~10% of the total area corresponds to submerged reefs. Forty-eight species were identified, seven more than known species at the VRS, 45 of the order of Escleractinia and 3 of the order of Anthoathecatae. Acropora prolifera, a hybrid, was also identified in most reefs. All species were observed in the emerged and submerged reefs. The distance at which the three local river discharges (Jamapa, La Antigua, and Actopan) brought sediments to the VRS was calculated. Those are inappropriate areas for coral settlement or development due to sediment transport and temperature and salinity fluctuation. Finally, light penetration was measured at 19 m depth near one reef structure during August 2016 suggesting that even during cloud coverage and rain periods there was a light bioavailability at the sampling point.

https://doi.org/10.3856/vol47-issue2-fulltext-7 514 downloads

Propagación de grietas por fatiga de acero al carbono con y sin soldadura mig
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Ramírez-Cruz, José Luis

; Terán-Guillén, Jorge

; Barba-Pingarrón, Arturo

; Carrera-Bolaños, Jorge

; González-Parra, Rafael

; Ordoñez-Hernández, Urbano

Ingeniería Mecánica

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dec 2018, Volume 21 N. 3 Pages 167 - 172

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract In this paper are presented the results of a research work on the propagation of fatigue cracks in structural steel plate, subjected to a MIG welding process. The study was conducted on structural steel (ASTM std.) used in the manufacture of structures of rectangular tubular profile (PTR) for 2 x 1inch 2-mm thick, MIG welded and not welded. Samples were tested for fatigue crack propagation at the base material and welded metal. The results show a crack arrest in the heat affected zone (HAZ) , requiring greater amplitude of the stress intensity factor (KI) for the propagation of the crack in a stable manner. Results indicate that the combination of adequate microstructure and residual stresses in the HAZ are the main factors which can stop the advance of the crack in welded material.

Resumen En este trabajo se presentan los resultados de una investigación sobre la propagación de grietas por fatiga en una lámina de acero estructural sometida a un proceso de soldadura MIG. El estudio se realizó en el acero estructural AISI 1018 utilizado en la fabricación de estructuras de perfil tubular rectangular (PTR) de 2 x 1 pulgadas, de 2 mm de espesor con y sin cordón de soldadura. Se realizaron pruebas de propagación de grietas por fatiga, en el material base y en el soldado. Los resultados muestran una detención de grieta en la zona afectada por el calor, requiriendo mayor amplitud del factor de intensidad de esfuerzos (KI) para que la grieta se propague de una manera estable. Los resultados indican que la combinación de una adecuada microestructura y los esfuerzos residuales en la zona afectada por el calor, son los factores que más influyen en la detención del avance de la grieta en el material soldado.

Formación de esclerocios en Morchella esculenta y M. cónica, in vitro
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Alvarado-Castillo, Gerardo

; Mata, Gerardo

; Pérez-Vázquez, Arturo

; Martínez-Carrera, Daniel

; Nava-Tablada, Martha Elena

; Gallardo-López, Felipe

; Osorio-Acosta, Francisco

Revista mexicana de micología

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jun 2012, Volume 35 Pages 35 - 41

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

The strains IE-750 (M. esculenta) and IE-816 (M. conica) were used and cultivated in a culture media supplemented with compost. Seven stages were identified during sclerotia formation process: 1. Hyphal growth, 2. Primary mycelia growth and branching, 3. Secondary mycelia interweaving, 4. Formation of compact masses, 5. Growth of compact masses, 6. Sclerotia formation, and 7. Sclerotia growth and maturation. Chlamydospores and conidia were also observed during sclerotia formation process, suggesting Morchella displays diverse reproduction and survival strategies under different environmental conditions.

Se identificaron las etapas y procesos de formación de esclerocios de Morchella esculenta y M. conica in vitro, cultivadas en un medio de cultivo suplementado con composta, utilizando las cepas IE-750 (M. esculenta) e IE-816 (M. conica). En la morfogénesis observada se identificaron siete etapas: 1. Crecimiento de hifas principales, 2. Crecimiento y ramificación de hifas secundarias, 3. Entrelazamiento de hifas secundarias, 4. Formación de masas compactas, 5. Crecimiento de masas compactas, 6. Formación de esclerocios y 7. Crecimiento y maduración de esclerocios. También se observó la formación de clamidosporas durante la formación de esclerocios, lo que sugiere que Morchella presenta diversas estrategias de reproducción y sobrevivencia ante diferentes condiciones ambientales.

6750 downloads Cited 3 times in SciELO

Examen nacional de medicina en Perú 2008 - 2009: análisis y sostenibilidad de los resultados
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Cieza Zevallos, Javier Antonio

; León Rabanal, Cristian Paul

; Huapaya Carrera, Julio Arturo

; Miyahira Arakaki, Juan Manuel

Acta Médica Peruana

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apr 2010, Volume 27 N. 2 Pages 99 - 104

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Objective: To assess the consistency of the results of the National Medicine Exam (NME) in Peru for years 2008 and 2009. Material and method: We examined consistency between general and partial results obtained by the different public and private medical schools from Lima or other cities using official published data regarding the results of NME in Peru for years 2008 and 2009. These results were analyzed taking into account both numerical scores and ordinal variables (when considering the order on the basis of partial results that resulted in the final rank order). Statistical significance was established in p<0.05. Results: The correlation was good (r>0.90) between the order considering the overall score and rank order in the two periods studied, but the best result was obtained in 2008. The correlation between the rank order obtained in both years was low, with a statistically significant result (r=0.69, p<0.001). The consistency of partial results from universities between 2008 and 2009 was non-existent except in the pediatrics area. The results were different in terms of coming from a public or a private university (both in the overall score and in the medicine area) and being based in Lima or another city (for obstetrics and gynecology and public health items). The model consisting in being a public medical school based in Lima showed a different behavior compared to other variable combinations. Conclusion: NME results in years 2008 and 2009 showed poor consistency. The results showed a different behavior of public Lima/based medical schools compared with other variable combinations.

Objetivo: Analizar la consistencia de los resultados del ENAM 2008 y 2009. Material y método: Con datos oficiales publicados de los resultados del ENAM 2008 y 2009 se exploró la consistencia entre los resultados generales y parciales obtenidos por las diferentes universidades definidas como estatales y privadas de Lima u otra ciudad. Se analizó los resultados considerando los puntajes obtenidos como variables numéricas y ordinales (cuando se consideró el orden en función de los ordenamientos parciales que dieron como resultado el orden jerárquico final). Se aceptó como significancia estadística p<0,05. Resultados: La correlación fue buena (r>0,90) entre el orden según el puntaje general y el orden jerárquico en los dos períodos estudiados, siendo mejor en el 2008. La correlación entre el orden jerárquico obtenido en ambos años estudiados fue pobre pero estadísticamente significativa (r=0,69, p<0,001). La consistencia de los resultados parciales de las universidades entre el 2008 y 2009 fue inexistente excepto en el área de pediatría. Los resultados fueron diferentes en función de ser universidad estatal o privada (en el puntaje general y en el área de medicina) y en función de ser de Lima o de otra ciudad (en áreas de ginecologíaobstetricia y salud pública). El modelo de ser universidad estatal y de Lima mostró un comportamiento diferente a otras combinaciones. Conclusión: Los resultados obtenidos por las universidades en los ENAM de los años 2008 y 2009 mostraron pobre consistencia. Los resultados mostraron un comportamiento diferente de las universidades estatales y de Lima en relación a otras combinaciones.

Lymph scrotum: an unusual urological presentation of lymphatic filariasis. A case series study
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Aguiar-Santos, Ana Maria

; Leal-Cruz, Marcela

; Netto, Maria José

; Carrera, Arturo

; Lima, Guilherme

; Rocha, Abraham

Revista do Instituto de Medicina Tropical de São Paulo

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aug 2009, Volume 51 N. 4 Pages 179 - 183

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A filariose linfática (FL) é responsável por uma grande variedade de sinais e sintomas clínicos incluindo manifestações urogenitais. O controle da transmissão e da incapacitação bem como o manuseio da morbidade são os dois pilares da estratégia global de eliminação da FL. O linfoescroto é uma rara apresentação da FL, tendo importantes repercussões do ponto de vista clínico, psicológico e socioeconômico. Realizou-se um estudo retrospectivo de uma série de casos com diagnóstico de linfoescroto, identificados entre os 6.361 pacientes ambulatoriais atendidos no período de 2000 a 2007 no Serviço de Referência Nacional em Filarioses (Recife, Brasil) área endêmica de filariose. Foram identificados sete casos, com a idade média de 45 anos (com variação de 26 a 64 anos). O tempo médio de evolução da doença foi de 8,5 anos (com variação de 2 a 15 anos). Todos apresentavam evidência de infecção filarial por algum dos exames realizados (parasitológico, pesquisa antigênica ou "sinal da dança da filaria" na ultrasonografia). Seis pacientes relatavam historia prévia de cirurgia urológica. Os autores destacam a importância da associação da infecção filarial e de inadequado manuseio cirúrgico e de acompanhamento de pacientes com hidrocele de uma área endêmica, como fatores de risco para o surgimento de linfoescroto. Assim, a infecção filarial deve ser rotineiramente investigada em todos os indivíduos procedentes de áreas endêmicas apresentando morbidade urológica, para identificar melhor os elementos da cadeia de transmissão.

Lymphatic filariasis (LF) causes a wide range of clinical signs and symptoms, including urogenital manifestations. Transmission control and disability/morbidity management/control are the two pillars of the overall elimination strategy for LF. Lymph scrotum is an unusual urological clinical presentation of LF with important medical, psychological, social and economic repercussions. A retrospective case series study was conducted on outpatients attended at the National Reference Service for Filariasis, in an endemic area for filariasis (Recife, Brazil), between 2000 and 2007. Over this period, 6,361 patients were attended and seven cases with lymph scrotum were identified. Mean patient age was 45 years (range, 26 to 64 years). Mean disease duration was 8.5 years (range, two to 15 years). All patients had evidence of filarial infection from at least one laboratory test (parasitological, antigen investigation or "filarial dance sign" on ultrasound). Six patients presented histories of urological surgery. The authors highlight the importance of the association between filarial infection and the inadequate surgical and clinical management of hydrocele in an endemic area, as risk factors for lymph scrotum. Thus, filarial infection should be routinely investigated in all individuals presenting urological morbidity within endemic areas, in order to identify likely links in the transmission chain.

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Comparison of tests for the detection of circulating filarial antigen (Og4C3-ELISA and AD12-ICT) and ultrasound in diagnosis of lymphatic filariasis in individuals with microfilariae
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Rocha, Abraham

; Braga, Cynthia

; Belém, Marcela

; Carrera, Arturo

; Aguiar-Santos, Ana

; Oliveira, Paula

; Texeira, Maria José

; Furtado, André

Memórias do Instituto Oswaldo Cruz

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jul 2009, Volume 104 N. 4 Pages 621 - 625

Abstract: En | Text: En | PDF: En

Significant advances were made in the diagnosis of filariasis in the 1990s with the emergence of three new alternative tools: ultrasound and tests to detect circulating antigen using two monoclonal antibodies, Og4C3 and AD12-ICT-card. This study aimed to identify which of these methods is the most sensitive for diagnosis of infection. A total of 256 individuals, all male and carrying microfilariae (1-15,679 MF/mL), diagnosed by nocturnal venous blood samples, were tested by all three techniques. The tests for circulating filarial antigen concurred 100% and correctly identified 246/256 (96.69%) of the positive individuals, while ultrasound detected only 186/256 (73.44%). Of the circulating antigen tests, ICT-card was the most convenient method for identification of Wuchereria bancrofti carriers. It was easy to perform, practical and quick.

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