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1.
Energy dynamics of broiler in thermoneutral or heat stress environments with different levels of metabolizable energy
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Teixeira, Maurício de Paula Ferreira
; Soares, Kamilla Ribas
; Silva, Ricardo Reis e
; Pereira, Luiz Felipe Pinho
; Gondim, Cristiano Werneck Rocha
; Pompeu, Mariana André
; Nascimento, Thiago Pajeú
; Baião, Nelson Carneiro
; Lara, Leonardo José Camargos
.









ABSTRACT: Two experiments evaluated the effect of different levels of metabolizable energy (ME) on nutrient metabolizability, energy balance, and broiler performance under thermoneutral and cyclic heat stress conditions. A total of 672 male Cobb™ broilers were used, with ME levels of 2980, 3080, 3180, and 3280 kcal/kg in the diets. In a thermoneutral environment (experiment 1), higher ME levels improved the ether extract metabolizability coefficient, apparent metabolizable energy corrected for nitrogen balance (AMEn), and net energy (NE). However, increased ME from oil inclusion did not affect feed intake, apparent ME intake, retained energy, total and fasting heat production, caloric increment, or the efficiency of energy use for AMEn and NE. It did enhance weight gain, productive efficiency index, and feed conversion but reduced viability and increased feed cost per kg of live chicken. Under cyclic heat stress (experiment 2), the metabolizability coefficient of crude protein and ether extract rose with increased ME. Higher ME reduced the caloric increment up to an estimated 3021.5 ME and increased AMEn and NE. Improved feed conversion was noted, but feed cost per kg of live broiler also rose. In conclusion, the increase in energy levels positively affected the performance parameters of broilers from 20 to 41 days of age, particularly feed conversion, but it also raised production costs.
RESUMO: Dois experimentos avaliaram o efeito de diferentes níveis de energia metabolizável (EM) sobre a metabolizabilidade de nutrientes, balanço energético e desempenho de frangos de corte em condições termoneutras e de estresse cíclico por calor. Um total de 672 frangos de corte machos Cobb™ foram utilizados, com níveis de EM de 2980, 3080, 3180 e 3280 kcal/kg nas dietas. Em um ambiente termoneutro (experimento 1), os níveis mais altos de EM melhoraram o coeficiente de metabolizabilidade do extrato etéreo, a energia metabolizável aparente corrigida para o balanço de nitrogênio (EMAn) e a energia líquida (EL). No entanto, o aumento da EM proveniente da inclusão de óleo não afetou o consumo de ração, a ingestão de EM aparente, a energia retida, a produção de calor total e em jejum, o incremento calórico, ou a eficiência do uso de energia para EMAn e EL. Houve, no entanto, aumento no ganho de peso, no índice de eficiência produtiva e na conversão alimentar, mas a viabilidade foi reduzida e o custo da ração por kg de frango vivo aumentou. Sob estresse térmico cíclico (experimento 2), o coeficiente de metabolizabilidade da proteína bruta e do extrato etéreo aumentou com o aumento da EM. Níveis mais altos de EM reduziram o incremento calórico até um valor estimado de 3021,5 EM e aumentaram a EMAn e a EL. A melhor conversão alimentar foi observada, mas o custo da ração por kg de frango vivo também subiu. Em conclusão, o aumento dos níveis de energia afetou positivamente os parâmetros de desempenho de frangos de corte de 20 a 41 dias de idade, especialmente a conversão alimentar, mas também elevou os custos de produção.
2.
Stepped-fat Dipole Antenna for TV 3.0 Design and Outdoor Tests
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Perotoni, Marcelo Bender
; Santos, Edson Tafeli Carneiro dos
; Vieira, Marcos Stefanelli
; Rabaça, Ricardo Seriacopi
; Fernandes, Natalia Castro
; Silva, Leonardo Henrique Gonsioroski Furtado da
; Santos, Amanda Beatriz Cunha dos
; Mello, Luiz Alencar Reis da Silva
; Akamine, Cristiano
.









Journal of Microwaves, Optoelectronics and Electromagnetic Applications
- Journal Metrics
Abstract This article describes a two-element antenna designed in a Digital Terrestrial Television Broadcasting (DTTB) Multiple Input Multiple Output (MIMO) 2×2 front antenna in the 470 to 700 MHz band. It is based on a planar, canonical, fat-dipole element with low-cost and robust characteristics. Both antenna elements are fed directly by a coaxial connector, without a balun, and have been optimized to provide low coupling, improving their combined diversity gain. The array occupies an area of 0.76λ2o x 0.51λ2o (907 cm2) at the center frequency wavelength. Measurements of the antennas in outdoor urban environments are presented with a technology proponent for the project, the Advanced Integrated Services Digital Broadcasting - Terrestrial (ISDB-T), in 8 urban sites in Rio de Janeiro, Brazil. The results showed that the proposed MIMO 2×2 antenna operates effectively in outdoor applications, is robust, has a low development cost, and has a low degree of mutual coupling.
3.
Nutritional requirements of digestible methionine+cystine for laying Japanese quails
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Oliveira, Jamilly Lima Ferreira
; Silva, Yasmin Maria Nunes
Rangel, Eloisa de Souza
Holanda, Mônica Calixto Ribeiro de
Lucena, Leandro Ricardo Rodrigues de
Holanda, Marco Aurélio Carneiro de

ABSTRACT. The objective of the present research is to determine optimal levels of digestible methionine+cystine to maximize the laying percentage and to improve the food conversion per egg mass of Japanese quails (Coturnix coturnix japonica). The experimental period was divided into three evaluation cycles, using 175 Japanese quails in the laying phase, with an initial age of 60 days, distributed in a completely randomized design, with five treatments and five replications. The treatments consisted of five levels of methionine+digestible cystine (0.742; 0.842; 0.942; 1.042; 1.142%). The performance variables measured were: daily feed consumption, average egg weight, laying percentage and feed conversion per egg mass. For the three evaluation cycles there was no difference in daily feed consumption and average egg weight, while the laying percentage and feed conversion per egg mass showed a quadratic behavior with a peak egg laying percentage of 97.81% and minimum feed conversion per egg mass of 2.39. Level of methionine+cystine necessary to obtain a peak in laying percentage is 0.942%, which provides better feed conversion rates for birds, with methionine+cystine consumption estimated between 253 mg bird-1day-1 and ratio methionine+cystine/lysine of 0.836 %.
4.
Multicenter observational study of patients who underwent cardiac surgery and were hospitalized in an intensive care unit (BraSIS 2): study protocol and statistical analysis plan
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Vasconcelos, Nair Naiara Barros de
; Chaves, Renato Carneiro de Freitas
; Pellegrino, Carolina de Moraes
; Souza, Guilherme Martins de
; Queiroz, Veronica Neves Fialho
; Barbas, Carmen Silvia Valente
; Takaoka, Flávio
; Cordioli, Ricardo Luiz
; Mangini, Sandrigo
; Papa, Fabio de Vasconcelos
; Guimarães, Hélio Penna
; Pereira, Adriano José
; Serpa Neto, Ary
; Gulinelli, Andre
; Legal, Anna Clara
; Jaoude, Caio Vinicius Gouvêa
; Paolinelli, Eduardo
; Lineburger, Eric Benedet
; Albuquerque, Erick César de Farias
; Ferreira Filho, Evaldo Gomes
; Hohmann, Fabio Barlem
; Galdino, Felipe
; Vianna, Felipe Souza Lima
; Dall’Orto, Frederico Toledo Campo
; Tramujas, Lucas
; Silva, Luciano Ribeiro Pereira
; Goncharov, Maxim
; Gottardo, Paulo César
; Rabello Filho, Roberto
; Midega, Thais Dias
Galindo, Vinicius Barbosa
Quintão, Vinícius Caldeira
Veiga, Viviane Cordeiro
Corrêa, Thiago Domingos
Silva Júnior, João Manoel





























ABSTRACT Background The perioperative management of patients undergoing cardiac surgery is highly complex and involves numerous factors. There is a strong association between cardiac surgery and perioperative complications. The Brazilian Surgical Identification Study (BraSIS 2) aims to assess the incidence of death and early postoperative complications, identify potential risk factors, and examine both the demographic characteristics of patients and the epidemiology of cardiovascular procedures. Methods and analysis BraSIS 2 is a multicenter observational study of patients who undergo cardiac surgery and who are admitted to the intensive care unit. The primary objective is to describe the risk factors and incidence of mortality or severe postoperative complications occurring within the first 3 postoperative days of cardiac surgery or until intensive care unit discharge (whichever event occurs first). Severe postoperative complications include acute myocardial infarction, acute respiratory distress syndrome, cardiorespiratory arrest with return of spontaneous circulation, Kidney Disease Improving Global Outcomes stage ≥ 2, a new surgical approach being conducted in an unscheduled event of urgency or emergency, renal replacement therapy, septic shock, severe bleeding, severe hemodynamic instability, stroke, unplanned reintubation, and unplanned use of a circulatory assistance device. The secondary outcomes include the evaluation of patient characteristics and descriptions of the performed surgeries and administered anesthesia. This study will also assess intraoperative and postoperative complications, as well as risk factors associated with postoperative complications and mortality. We expect to recruit 500 patients from at least 10 Brazilian intensive care units. Trial registration: NCT06154473; partial results.
5.
Acoustic radiation force Impulse elastography to aid diagnosis of two canine malignant peripheral nerve sheath tumors
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Cruz, Igor Cezar Kniphoff da
; Carneiro, Rafael Kretzer
; Maronezi, Marjury Cristina
; Lima, Bruna Bressianini
; Gouveia, Marcelo Cândido Portilho
; Uscategui, Ricardo Andrés Ramirez
; Minto, Bruno Watanabe
; Hörbe, Anna Vitória
; Feliciano, Marcus Antônio Rossi
.









ABSTRACT: This report described the use of acoustic radiation force impulse (ARFI) elastography in the diagnosis of two cases of canine malignant peripheral nerve sheath tumors. Both patients presented with lameness in the thoracic limb and no response to previous clinical treatment or trauma history. Physical examination revealed muscular atrophy in one of the thoracic limbs, in both dogs. B-mode axillary ultrasound showed the presence of a predominantly hypoechogenic, heterogeneous, irregular, nonencapsulated nodule with adjacent reactivity, measuring approximately 20.1 mm x 15.4 mm in the first case and 18.3 mm x 10.7 mm in the second. ARFI elastography was performed, showing areas of significant stiffness, with an average shear wave velocity of 4.12 m/s (case 1) and 4.35 m/s (case 2), suggesting malignancy. In both cases, the affected limb was amputated, and the tumors sent for histopathological analysis, which were; subsequently, diagnosed as malignant tumors of the peripheral nerve sheath. The ultrasonographic methods used were essential in the diagnosis and therapeutic conduct.
RESUMO: O objetivo deste relato é descrever o auxílio da elastografia por impulso de força de radiação acústica (ARFI) no diagnóstico de dois casos de tumores malignos da bainha dos nervos periféricos em canídeos. Ambos os pacientes apresentavam claudicação em membro torácico e já haviam sido tratados clinicamente por outros profissionais, sem resposta ao tratamento ou histórico de trauma. Ao exame físico, foi observada atrofia muscular em apenas um dos membros torácicos, nos dois casos. Foi realizado exame ultrassonográfico axilar. Na avaliação modo B, foi observada a presença de estrutura nodular, predominantemente hipoecogênica, heterogênea, irregular, não encapsulada e com reatividade adjacente, medindo aproximadamente 20.1 mm x 15.4 mm no primeiro caso e 18.3 mm x 10.7 mm no segundo caso. Foi realizada elastografia ARFI, demonstrando a presença de áreas de maior rigidez, com velocidade de ondas de cisalhamento média de 4.12 m/s (caso 1) e 4.35 m/s (caso 2), sugerindo malignidade. Em ambos os casos, foi realizada amputação do membro afetado e os nódulos removidos foram encaminhados para análise histopatológica, na qual se obteve o diagnóstico de tumor maligno da bainha de nervo periférico. Os métodos ultrassonográficos realizados nesses casos foram essenciais para o diagnóstico e conduta terapêutica.
6.
Characterization of dark septate endophytic fungi Periconia macrospinosa isolated from roots of sugarcane in São Paulo, Brazil
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SILVA, LUANA C.
; SAGGIN-JÚNIOR, ORIVALDO JOSÉ
; CARNEIRO, MARCO AURÉLIO C.
; SILVA, ELIANE MARIA R. DA
; ZILLI, JERRI ÉDSON
; BERBARA, RICARDO LUIS L.
.






Anais da Academia Brasileira de Ciências
- Journal Metrics
Abstract Dark Septate Endophytic (DSE) fungi can benefit plants by optimizing nutrient uptake, biosynthesis of phytohormones-like compounds, and stress relief such as toxic metals. The objective was to characterize in vitro 57 strains of the DSE Periconia macrospinosa isolated from sugarcane roots, indicating the most promising in solubilizing phosphate sources, growing in different metal and vinasse contents, and producing molecules related to indoleacetic acid (IAA). The strains were from the Embrapa Agrobiology Fungi Collection. Over 35% of the strains solubilize calcium phosphate, highlighting A356 and A155. No strain solubilizes aluminum phosphate. Three strains did not grow in the presence of Cd (A333, A334, A163), but A226, A332, and A423 stand out showing high growth with Cd. All strains grew in the presence of Cu, Zn, and Vinasse. A163, A164, and A328 were even stimulated by Cu addition. A331 and A335 showed a marked growth decrease with Zn. All strains are highly adapted to grow in vinasse presence. A257 and A226 produced the highest amount of IAA. The most biotechnological potential strains are indicated by presenting high growth under Cd, Cu, Zn, and vinasse stress, associated with a high tolerance index to these pollutants, further calcium phosphate solubilization, or IAA production.
7.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
Slipinski, Adam
Linzmeier, Adelita M.
Calor, Adolfo R.
Garda, Adrian A.
Kury, Adriano B.
Fernandes, Agatha C.S.
Agudo-Padrón, Aisur I.
Akama, Alberto
Silva Neto, Alberto M. da
Burbano, Alejandro L.
Menezes, Aleksandra
Pereira-Colavite, Alessandre
Anichtchenko, Alexander
Lees, Alexander C.
Bezerra, Alexandra M.R.
Domahovski, Alexandre C.
Pimenta, Alexandre D.
Aleixo, Alexandre L.P.
Marceniuk, Alexandre P.
Paula, Alexandre S. de
Somavilla, Alexandre
Specht, Alexandre
Camargo, Alexssandro
Newton, Alfred F.
Silva, Aline A.S. da
Santos, Aline B. dos
Tassi, Aline D.
Aragão, Allan C.
Santos, Allan P.M.
Migotto, Alvaro E.
Mendes, Amanda C.
Cunha, Amanda
Chagas Júnior, Amazonas
Sousa, Ana A.T. de
Pavan, Ana C.
Almeida, Ana C.S.
Peronti, Ana L.B.G.
Henriques-Oliveira, Ana L.
Prudente, Ana L.
Tourinho, Ana L.
Pes, Ana M.O.
Carmignotto, Ana P.
Wengrat, Ana P.G. da Silva
Dornellas, Ana P.S.
Molin, Anamaria Dal
Puker, Anderson
Morandini, André C.
Ferreira, André da S.
Martins, André L.
Esteves, André M.
Fernandes, André S.
Roza, André S.
Köhler, Andreas
Paladini, Andressa
Andrade, Andrey J. de
Pinto, Ângelo P.
Salles, Anna C. de A.
Gondim, Anne I.
Amaral, Antonia C.Z.
Rondón, Antonio A.A.
Brescovit, Antonio
Lofego, Antônio C.
Marques, Antonio C.
Macedo, Antonio
Andriolo, Artur
Henriques, Augusto L.
Ferreira Júnior, Augusto L.
Lima, Aurino F. de
Barros, Ávyla R. de A.
Brito, Ayrton do R.
Romera, Bárbara L.V.
Vasconcelos, Beatriz M.C. de
Frable, Benjamin W.
Santos, Bernardo F.
Ferraz, Bernardo R.
Rosa, Brunno B.
Sampaio, Brunno H.L.
Bellini, Bruno C.
Clarkson, Bruno
Oliveira, Bruno G. de
Corrêa, Caio C.D.
Martins, Caleb C.
Castro-Guedes, Camila F. de
Souto, Camilla
Bicho, Carla de L.
Cunha, Carlo M.
Barboza, Carlos A. de M.
Lucena, Carlos A.S. de
Barreto, Carlos
Santana, Carlos D.C.M. de
Agne, Carlos E.Q.
Mielke, Carlos G.C.
Caetano, Carlos H.S.
Flechtmann, Carlos H.W.
Lamas, Carlos J.E.
Rocha, Carlos
Mascarenhas, Carolina S.
Margaría, Cecilia B.
Waichert, Cecilia
Digiani, Celina
Haddad, Célio F.B.
Azevedo, Celso O.
Benetti, Cesar J.
Santos, Charles M.D. dos
Bartlett, Charles R.
Bonvicino, Cibele
Ribeiro-Costa, Cibele S.
Santos, Cinthya S.G.
Justino, Cíntia E.L.
Canedo, Clarissa
Bonecker, Claudia C.
Santos, Cláudia P.
Carvalho, Claudio J.B. de
Gonçalves, Clayton C.
Galvão, Cleber
Costa, Cleide
Oliveira, Cléo D.C. de
Schwertner, Cristiano F.
Andrade, Cristiano L.
Pereira, Cristiano M.
Sampaio, Cristiano
Dias, Cristina de O.
Lucena, Daercio A. de A.
Manfio, Daiara
Amorim, Dalton de S.
Queiroz, Dalva L. de
Queiroz, Dalva L. de
Colpani, Daniara
Abbate, Daniel
Aquino, Daniel A.
Burckhardt, Daniel
Cavallari, Daniel C.
Prado, Daniel de C. Schelesky
Praciano, Daniel L.
Basílio, Daniel S.
Bená, Daniela de C.
Toledo, Daniela G.P. de
Takiya, Daniela M.
Fernandes, Daniell R.R.
Ament, Danilo C.
Cordeiro, Danilo P.
Silva, Darliane E.
Pollock, Darren A.
Muniz, David B.
Gibson, David I.
Nogueira, David S.
Marques, Dayse W.A.
Lucatelli, Débora
Garcia, Deivys M.A.
Baêta, Délio
Ferreira, Denise N.M.
Rueda-Ramírez, Diana
Fachin, Diego A.
Souza, Diego de S.
Rodrigues, Diego F.
Pádua, Diego G. de
Barbosa, Diego N.
Dolibaina, Diego R.
Amaral, Diogo C.
Chandler, Donald S.
Maccagnan, Douglas H.B.
Caron, Edilson
Carvalho, Edrielly
Adriano, Edson A.
Abreu Júnior, Edson F. de
Pereira, Edson H.L.
Viegas, Eduarda F.G.
Carneiro, Eduardo
Colley, Eduardo
Eizirik, Eduardo
Santos, Eduardo F. dos
Shimbori, Eduardo M.
Suárez-Morales, Eduardo
Arruda, Eliane P. de
Chiquito, Elisandra A.
Lima, Élison F.B.
Castro, Elizeu B. de
Orlandin, Elton
Nascimento, Elynton A. do
Razzolini, Emanuel
Gama, Emanuel R.R.
Araujo, Enilma M. de
Nishiyama, Eric Y.
Spiessberger, Erich L.
Santos, Érika C.L. dos
Contreras, Eugenia F.
Galati, Eunice A.B.
Oliveira Junior, Evaldo C. de
Gallardo, Fabiana
Hernandes, Fabio A.
Lansac-Tôha, Fábio A.
Pitombo, Fabio B.
Dario, Fabio Di
Santos, Fábio L. dos
Mauro, Fabio
Nascimento, Fabio O. do
Olmos, Fabio
Amaral, Fabio R.
Schunck, Fabio
Godoi, Fábio S. P. de
Machado, Fabrizio M.
Barbo, Fausto E.
Agrain, Federico A.
Ribeiro, Felipe B.
Moreira, Felipe F.F.
Barbosa, Felipe F.
Silva, Fenanda S.
Cavalcanti, Fernanda F.
Straube, Fernando C.
Carbayo, Fernando
Carvalho Filho, Fernando
Zanella, Fernando C.V.
Jacinavicius, Fernando de C.
Farache, Fernando H.A.
Leivas, Fernando
Dias, Fernando M.S.
Mantellato, Fernando
Vaz-de-Mello, Fernando Z.
Gudin, Filipe M.
Albuquerque, Flávio
Molina, Flavio B.
Passos, Flávio D.
Shockley, Floyd W.
Pinheiro, Francielly F.
Mello, Francisco de A.G. de
Nascimento, Francisco E. de L.
Franco, Francisco L.
Oliveira, Francisco L. de
Melo, Francisco T. de V.
Quijano, Freddy R.B.
Salles, Frederico F.
Biffi, Gabriel
Queiroz, Gabriel C.
Bizarro, Gabriel L.
Hrycyna, Gabriela
Leviski, Gabriela
Powell, Gareth S.
Santos, Geane B. dos
Morse, Geoffrey E.
Brown, George
Mattox, George M.T.
Zimbrão, Geraldo
Carvalho, Gervásio S.
Miranda, Gil F.G.
Moraes, Gilberto J. de
Lourido, Gilcélia M.
Neves, Gilmar P.
Moreira, Gilson R.P.
Montingelli, Giovanna G.
Maurício, Giovanni N.
Marconato, Gláucia
Lopez, Guilherme E.L.
Silva, Guilherme L. da
Muricy, Guilherme
Brito, Guilherme R.R.
Garbino, Guilherme S.T.
Flores, Gustavo E.
Graciolli, Gustavo
Libardi, Gustavo S.
Proctor, Heather C.
Gil-Santana, Helcio R.
Varella, Henrique R.
Escalona, Hermes E.
Schmitz, Hermes J.
Rodrigues, Higor D.D.
Galvão Filho, Hilton de C.
Quintino, Hingrid Y.S.
Pinto, Hudson A.
Rainho, Hugo L.
Miyahira, Igor C.
Gonçalves, Igor de S.
Martins, Inês X.
Cardoso, Irene A.
Oliveira, Ismael B. de
Franz, Ismael
Fernandes, Itanna O.
Golfetti, Ivan F.
S. Campos-Filho, Ivanklin
Oliveira, Ivo de S.
Delabie, Jacques H.C.
Oliveira, Jader de
Prando, Jadila S.
Patton, James L.
Bitencourt, Jamille de A.
Silva, Janaina M.
Santos, Jandir C.
Arruda, Janine O.
Valderrama, Jefferson S.
Dalapicolla, Jeronymo
Oliveira, Jéssica P.
Hájek, Jiri
Morselli, João P.
Narita, João P.
Martin, João P.I.
Grazia, Jocélia
McHugh, Joe
Cherem, Jorge J.
Farias Júnior, José A.S.
Fernandes, Jose A.M.
Pacheco, José F.
Birindelli, José L.O.
Rezende, José M.
Avendaño, Jose M.
Duarte, José M. Barbanti
Ribeiro, José R. Inácio
Mermudes, José R.M.
Pujol-Luz, José R.
Santos, Josenilson R. dos
Câmara, Josenir T.
Teixeira, Joyce A.
Prado, Joyce R. do
Botero, Juan P.
Almeida, Julia C.
Kohler, Julia
Gonçalves, Julia P.
Beneti, Julia S.
Donahue, Julian P.
Alvim, Juliana
Almeida, Juliana C.
Segadilha, Juliana L.
Wingert, Juliana M.
Barbosa, Julianna F.
Ferrer, Juliano
Santos, Juliano F. dos
Kuabara, Kamila M.D.
Nascimento, Karine B.
Schoeninger, Karine
Campião, Karla M.
Soares, Karla
Zilch, Kássia
Barão, Kim R.
Teixeira, Larissa
Sousa, Laura D. do N.M. de
Dumas, Leandro L.
Vieira, Leandro M.
Azevedo, Leonardo H.G.
Carvalho, Leonardo S.
Souza, Leonardo S. de
Rocha, Leonardo S.G.
Bernardi, Leopoldo F.O.
Vieira, Letícia M.
Johann, Liana
Salvatierra, Lidianne
Oliveira, Livia de M.
Loureiro, Lourdes M.A. El-moor
Barreto, Luana B.
Barros, Luana M.
Lecci, Lucas
Camargos, Lucas M. de
Lima, Lucas R.C.
Almeida, Lucia M.
Martins, Luciana R.
Marinoni, Luciane
Moura, Luciano de A.
Lima, Luciano
Naka, Luciano N.
Miranda, Lucília S.
Salik, Lucy M.
Bezerra, Luis E.A.
Silveira, Luis F.
Campos, Luiz A.
Castro, Luiz A.S. de
Pinho, Luiz C.
Silveira, Luiz F.L.
Iniesta, Luiz F.M.
Tencatt, Luiz F.C.
Simone, Luiz R.L.
Malabarba, Luiz R.
Cruz, Luiza S. da
Sekerka, Lukas
Barros, Lurdiana D.
Santos, Luziany Q.
Skoracki, Maciej
Correia, Maira A.
Uchoa, Manoel A.
Andrade, Manuella F.G.
Hermes, Marcel G.
Miranda, Marcel S.
Araújo, Marcel S. de
Monné, Marcela L.
Labruna, Marcelo B.
Santis, Marcelo D. de
Duarte, Marcelo
Knoff, Marcelo
Nogueira, Marcelo
Britto, Marcelo R. de
Melo, Marcelo R.S. de
Carvalho, Marcelo R. de
Tavares, Marcelo T.
Kitahara, Marcelo V.
Justo, Marcia C.N.
Botelho, Marcia J.C.
Couri, Márcia S.
Borges-Martins, Márcio
Felix, Márcio
Oliveira, Marcio L. de
Bologna, Marco A.
Gottschalk, Marco S.
Tavares, Marcos D.S.
Lhano, Marcos G.
Bevilaqua, Marcus
Santos, Marcus T.T.
Domingues, Marcus V.
Sallum, Maria A.M.
Digiani, María C.
Santarém, Maria C.A.
Nascimento, Maria C. do
Becerril, María de los A.M.
Santos, Maria E.A. dos
Passos, Maria I. da S. dos
Felippe-Bauer, Maria L.
Cherman, Mariana A.
Terossi, Mariana
Bartz, Marie L.C.
Barbosa, Marina F. de C.
Loeb, Marina V.
Cohn-Haft, Mario
Cupello, Mario
Martins, Marlúcia B.
Christofersen, Martin L.
Bento, Matheus
Rocha, Matheus dos S.
Martins, Maurício L.
Segura, Melissa O.
Cardenas, Melissa Q.
Duarte, Mércia E.
Ivie, Michael A.
Mincarone, Michael M.
Borges, Michela
Monné, Miguel A.
Casagrande, Mirna M.
Fernandez, Monica A.
Piovesan, Mônica
Menezes, Naércio A.
Benaim, Natalia P.
Reategui, Natália S.
Pedro, Natan C.
Pecly, Nathalia H.
Ferreira Júnior, Nelson
Silva Júnior, Nelson J. da
Perioto, Nelson W.
Hamada, Neusa
Degallier, Nicolas
Chao, Ning L.
Ferla, Noeli J.
Mielke, Olaf H.H.
Evangelista, Olivia
Shibatta, Oscar A.
Oliveira, Otto M.P.
Albornoz, Pablo C.L.
Dellapé, Pablo M.
Gonçalves, Pablo R.
Shimabukuro, Paloma H.F.
Grossi, Paschoal
Rodrigues, Patrícia E. da S.
Lima, Patricia O.V.
Velazco, Paul
Santos, Paula B. dos
Araújo, Paula B.
Silva, Paula K.R.
Riccardi, Paula R.
Garcia, Paulo C. de A.
Passos, Paulo G.H.
Corgosinho, Paulo H.C.
Lucinda, Paulo
Costa, Paulo M.S.
Alves, Paulo P.
Roth, Paulo R. de O.
Coelho, Paulo R.S.
Duarte, Paulo R.M.
Carvalho, Pedro F. de
Gnaspini, Pedro
Souza-Dias, Pedro G.B.
Linardi, Pedro M.
Bartholomay, Pedro R.
Demite, Peterson R.
Bulirsch, Petr
Boll, Piter K.
Pereira, Rachel M.M.
Silva, Rafael A.P.F.
Moura, Rafael B. de
Boldrini, Rafael
Silva, Rafaela A. da
Falaschi, Rafaela L.
Cordeiro, Ralf T.S.
Mello, Ramon J.C.L.
Singer, Randal A.
Querino, Ranyse B.
Heleodoro, Raphael A.
Castilho, Raphael de C.
Constantino, Reginaldo
Guedes, Reinaldo C.
Carrenho, Renan
Gomes, Renata S.
Gregorin, Renato
Machado, Renato J.P.
Bérnils, Renato S.
Capellari, Renato S.
Silva, Ricardo B.
Kawada, Ricardo
Dias, Ricardo M.
Siewert, Ricardo
Brugnera, Ricaro
Leschen, Richard A.B.
Constantin, Robert
Robbins, Robert
Pinto, Roberta R.
Reis, Roberto E. dos
Ramos, Robson T. da C.
Cavichioli, Rodney R.
Barros, Rodolfo C. de
Caires, Rodrigo A.
Salvador, Rodrigo B.
Marques, Rodrigo C.
Araújo, Rodrigo C.
Araujo, Rodrigo de O.
Dios, Rodrigo de V.P.
Johnsson, Rodrigo
Feitosa, Rodrigo M.
Hutchings, Roger W.
Lara, Rogéria I.R.
Rossi, Rogério V.
Gerstmeier, Roland
Ochoa, Ronald
Hutchings, Rosa S.G.
Ale-Rocha, Rosaly
Rocha, Rosana M. da
Tidon, Rosana
Brito, Rosangela
Pellens, Roseli
Santos, Sabrina R. dos
Santos, Sandra D. dos
Paiva, Sandra V.
Santos, Sandro
Oliveira, Sarah S. de
Costa, Sávio C.
Gardner, Scott L.
Leal, Sebastián A. Muñoz
Aloquio, Sergio
Bonecker, Sergio L.C.
Bueno, Sergio L. de S.
Almeida, Sérgio M. de
Stampar, Sérgio N.
Andena, Sérgio R.
Posso, Sergio R.
Lima, Sheila P.
Gadelha, Sian de S.
Thiengo, Silvana C.
Cohen, Simone C.
Brandão, Simone N.
Rosa, Simone P.
Ribeiro, Síria L.B.
Letana, Sócrates D.
Santos, Sonia B. dos
Andrade, Sonia C.S.
Dávila, Stephane
Vaz, Stéphanie
Peck, Stewart B.
Christo, Susete W.
Cunha, Suzan B.Z.
Gomes, Suzete R.
Duarte, Tácio
Madeira-Ott, Taís
Marques, Taísa
Roell, Talita
Lima, Tarcilla C. de
Sepulveda, Tatiana A.
Maria, Tatiana F.
Ruschel, Tatiana P.
Rodrigues, Thaiana
Marinho, Thais A.
Almeida, Thaís M. de
Miranda, Thaís P.
Freitas, Thales R.O.
Pereira, Thalles P.L.
Zacca, Thamara
Pacheco, Thaynara L.
Martins, Thiago F.
Alvarenga, Thiago M.
Carvalho, Thiago R. de
Polizei, Thiago T.S.
McElrath, Thomas C.
Henry, Thomas
Pikart, Tiago G.
Porto, Tiago J.
Krolow, Tiago K.
Carvalho, Tiago P.
Lotufo, Tito M. da C.
Caramaschi, Ulisses
Pinheiro, Ulisses dos S.
Pardiñas, Ulyses F.J.
Maia, Valéria C.
Tavares, Valeria
Costa, Valmir A.
Amaral, Vanessa S. do
Silva, Vera C.
Wolff, Vera R. dos S.
Slobodian, Verônica
Silva, Vinícius B. da
Espíndola, Vinicius C.
Costa-Silva, Vinicius da
Bertaco, Vinicius de A.
Padula, Vinícius
Ferreira, Vinicius S.
Silva, Vitor C.P. da
Piacentini, Vítor de Q.
Sandoval-Gómez, Vivian E.
Trevine, Vivian
Sousa, Viviane R.
Sant’Anna, Vivianne B. de
Mathis, Wayne N.
Souza, Wesley de O.
Colombo, Wesley D.
Tomaszewska, Wioletta
Wosiacki, Wolmar B.
Ovando, Ximena M.C.
Leite, Yuri L.R.








ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others.
8.
Artificial intelligence in the intensive care unit
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Midega, Thais Dias
; Chaves, Renato Carneiro de Freitas
; Nawa, Ricardo Kenji
; Mazza, Bruno Franco
; Ferraz, Leonardo José Rolim
; Corrêa, Thiago Domingos
.






9.
Influence of sodium chloride concentration on the dimensional stability of Eucalyptus wood
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Arantes, Lorran de Sousa
; Borges, Ianca Oliveira
; Hein, Paulo Ricardo Gherardi
; Oliveira, Bárbara Maria Ribeiro Guimarães de
; Kuhn, Leonardo Seibert
; Carneiro, Daniella Dutra
; Miranda, Larissa Nara Nascimento de
; Vale, Hekiciellen Pamella Nunes do
; Mendes, Lourival Marin
; Guimarães Júnior, José Benedito
.










ABSTRACT Evaluated the influence of the concentration of sodium chloride in the dimensional stability of Eucalyptus urophylla x Eucalyptus grandis. It was used 90 samples, which were saturated in beakers containing distilled water (control) and sodium chloride solution concentrations of 2.5% and 10%. Once saturated, the samples were dried until constant mass. The dimensions of the samples were determined for calculate the swelling and radial and tangential contractions. Woods of Eucalyptus urophylla x Eucalyptus grandis impregnated with sodium chloride solution at concentrations of 2.5 and 10% obtained tangential swelling values similar to those of the control. For radial swelling, wood impregnated with sodium chloride solution at a concentration of 2.5% reached lower values. The concentration of sodium chloride solution influenced the tangential and radial contraction of Eucalyptus urophylla x Eucalyptus grandis woods, as lower values were found for woods impregnated with sodium chloride solution at concentrations of 10 and 2.5%.
RESUMO Avaliou-se a influência da concentração de cloreto de sódio na estabilidade dimensional da madeira de Eucalyptus urophylla x Eucalyptus grandis. Foram utilizados 90 corpos de prova, na qual foram saturados em béqueres contendo água destilada (controle) e solução de cloreto de sódio com concentrações de 2,5% e 10%. Depois de saturados, os corpos de prova foram submetidos à secagem até atingirem massa constante. As dimensões dos corpos de prova foram determinadas para cálculo dos inchamentos e contrações radiais e tangenciais. Madeiras de Eucalyptus urophylla x Eucalyptus grandis impregnadas com solução de cloreto de sódio nas concentrações de 2,5 e 10% obtiveram valores de inchamento tangencial semelhantes ao do controle. Para o inchamento radial, as madeiras impregnadas com solução de cloreto de sódio na concentração de 2,5% atingiram menores valores. A concentração da solução de cloreto de sódio influenciou a contração tangencial e radial das madeiras de Eucalyptus urophylla x Eucalyptus grandis, pois menores valores foram encontrados para as madeiras impregnadas com solução de cloreto de sódio nas concentrações de 10 e 2,5%.
10.
Diretriz de Tomografia Computadorizada e Ressonância Magnética Cardiovascular da Sociedade Brasileira de Cardiologia e do Colégio Brasileiro de Radiologia – 2024
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Magalhães, Tiago Augusto
; Carneiro, Adriano Camargo de Castro
; Moreira, Valéria de Melo
; Trad, Henrique Simão
; Lopes, Marly Maria Uellendahl
; Cerci, Rodrigo Julio
; Nacif, Marcelo Souto
; Schvartzman, Paulo R.
; Chagas, Antônio Carlos Palandrini
; Costa, Isabela Bispo Santos da Silva
; Schmidt, André
; Shiozaki, Afonso Akio
; Montenegro, Sérgio Tavares
; Piegas, Leopoldo Soares
; Zapparoli, Marcelo
; Nicolau, José Carlos
; Fernandes, Fabio
; Hadlich, Marcelo Souza
; Ghorayeb, Nabil
; Mesquita, Evandro Tinoco
; Gonçalves, Luiz Flávio Galvão
; Ramires, Felix José Alvarez
; Fernandes, Juliano de Lara
; Schwartzmann, Pedro Vellosa
; Rassi, Salvador
; Torreão, Jorge Andion
; Mateos, José Carlos Pachón
; Beck-da-Silva, Luiz
; Silva, Marly Conceição
; Liberato, Gabriela
; Oliveira, Gláucia Maria Moraes de
; Feitosa Filho, Gilson Soares
; Carvalho, Hilka dos Santos Moraes de
; Markman Filho, Brivaldo
; Rocha, Ricardo Paulo de Sousa
; Azevedo Filho, Clerio Francisco de
; Taratsoutchi, Flávio
; Coelho-Filho, Otavio Rizzi
; Kalil Filho, Roberto
; Hajjar, Ludhmila Abrahão
; Ishikawa, Walther Yoshiharu
; Melo, Cíntia Acosta
; Jatene, Ieda Biscegli
; Albuquerque, Andrei Skromov de
; Rimkus, Carolina de Medeiros
; Silva, Paulo Savoia Dias da
; Vieira, Thiago Dieb Ristum
; Jatene, Fabio Biscegli
; Azevedo, Guilherme Sant Anna Antunes de
; Santos, Raul D.
; Monte, Guilherme Urpia
; Ramires, José Antonio Franchini
; Bittencourt, Marcio Sommer
; Avezum, Alvaro
; Silva, Leonardo Sara da
; Abizaid, Alexandre
; Gottlieb, Ilan
; Precoma, Dalton Bertolim
; Szarf, Gilberto
; Sousa, Antônio Carlos Sobral
; Pinto, Ibraim Masciarelli Francisco
; Medeiros, Fábio de Morais
; Caramelli, Bruno
; Parga Filho, José Rodrigues
Santos, Tiago Senra Garcia dos
Prazeres, Carlos Eduardo Elias dos
Lopes, Marcelo Antonio Cartaxo Queiroga
Avila, Luiz Francisco Rodrigues de
Scanavacca, Mauricio Ibrahim
Gowdak, Luis Henrique Wolff
Barberato, Silvio Henrique
Nomura, Cesar Higa
Rochitte, Carlos Eduardo































































11.
III BRAZILIAN CONSENSUS STATEMENT ON ENDOSCOPIC ULTRASOUND
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PESSOA, Ricardo Rangel de Paula
; BESTETTI, Alexandre Moraes
; OLIVEIRA, Victor Lira de
; ARAUJO, Wladimir Campos de
; GUARALDI, Simone
; RODRIGUES SILVA, Rodrigo Roda
; OLIVEIRA, Francisco Antonio Araujo
; RIBEIRO, Maria Sylvia Ierardi
; CARNEIRO, Fred Olavo Aragão Andrade
; D’ASSUNÇÃO, Marco Aurélio
; MEDRADO, Bruno Frederico Oliveira Azevedo
; RETES, Felipe Alves
; PAULO, Gustavo Andrade de
; SCHNEIDER, Nutianne Camargo
; ROSSINI, Lucio Giovanni Battista
; VALLINOTO, Leonardo
; ARDENGH, Jose Celso
; COELHO NETO, Djalma Ernesto
; IDE, Edson
; SILVA, Marcos Clarencio Batista
; FRANCO, Matheus Cavalcante
; MATUGUMA, Sergio Eiji
; MOURA, Diogo Turiani Hourneaux de
; ARANTES, Vitor Nunes
; NAHOUM, Rafael
; BRUNALDI, Vitor Ottoboni
; SANTOS, Marcos Eduardo Lera dos
; CHAVES, Dalton Marques
; MICELLI-NETO, Otávio
; SALOMAO, Bruno Chaves
; MALUF-FILHO, Fauze
; LUZ, Gustavo de Oliveira
.
































ABSTRACT Background: In the past decades, endoscopic ultrasound has developed from a diagnostic tool to a platform for many therapeutic interventions. Various technological advancements have emerged since the last Brazilian Consensus, demanding a review and update of the recommendations based on the best scientific evidence. Methods: A group of 32 renowned echoendoscopists selected eight relevant topics to be discussed to generate clinical questions. After that, a literature review was conducted to answer these questions based on the most updated evidence. Results: Thirty-three statements were formulated and voted on by the experts to reach a consensus. The Oxford System was used to grade the level of evidence. Conclusion: There is moderate evidence to support that the needle shape, gauge, or aspiration technique does not influence the yield of endoscopic ultrasound (EUS)-guided tissue sampling of pancreatic solid lesions. There is moderate evidence to support using EUS-TTNB of the cyst wall to differentiate between mucinous and non-mucinous cystic neoplasms. There is little evidence to support the EUS-guided treatment of gastric varices. There is a high level of evidence to support that EUS-guided biliary drainage and ERCP present similar outcomes in patients with distal malignant biliary obstruction. There is a high level of evidence for using EUS to diagnose neoplastic pancreatic cysts and detect necrosis before indicating drainage. There is moderate evidence to support EUS-GE over duodenal stent for malignant gastric outlet obstruction in patients with a life expectancy higher than 2 months. There is a high level of evidence to support the use of RFA in treating both functioning and non-functioning types of NET.
RESUMO Contexto: Nas últimas décadas, a ecoendoscopia evoluiu de uma ferramenta diagnóstica para uma plataforma para diversas intervenções terapêuticas. Vários avanços tecnológicos surgiram desde o último Consenso Brasileiro, demandando uma revisão e atualização das recomendações baseadas nas melhores evidências científicas. Métodos: Um grupo de 32 ecoendoscopistas renomados selecionou oito tópicos relevantes para serem discutidos a fim de gerar questões clínicas. Em seguida, foi realizada uma revisão da literatura para responder a essas perguntas com base nas evidências mais atualizadas. Resultados: Trinta e três tópicos foram formulados e votados pelos especialistas para alcançar um consenso. O Sistema de Oxford foi utilizado para classificar o nível de evidência. Conclusão: Há evidências moderadas para sustentar que a forma da agulha, calibre ou técnica de aspiração não influenciam no rendimento da amostragem tecidual guiada por ultrassom endoscópico (USE) de lesões sólidas pancreáticas. Há evidências moderadas para sustentar o uso da biópsia transcutânea guiada por USE da parede cística para diferenciar entre neoplasias císticas mucinosas e não mucinosas. Existem poucas evidências para apoiar o tratamento guiado por USE de varizes gástricas. Há um alto nível de evidência para sustentar que a drenagem biliar guiada por USE e a CPRE apresentam resultados semelhantes em pacientes com obstrução biliar maligna distal. Há um alto nível de evidência para o uso da USE no diagnóstico de cistos pancreáticos neoplásicos e na detecção de necrose antes de indicar a drenagem. Há evidências moderadas para sustentar a preferência pela gastroenterostomia guiada por USE em relação ao stent duodenal para obstrução maligna da saída gástrica em pacientes com expectativa de vida superior a 2 meses. Há um alto nível de evidência para sustentar o uso da ablação por radiofrequência no tratamento de ambos os tipos, funcionantes e não funcionantes, de tumores neuroendócrinos.
12.
A diallel model with repeatability information applied in an elephant grass breeding program
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Ferreira, Ricardo Augusto Diniz Cabral
; Pessoa, Tatiana Vilela de Souza
; Silva, Fabyano Fonseca e
; Dias, Kaio Olimpio das Graças
; Carneiro, Pedro Crescêncio Souza
; Cruz, Cosme Damião
; Machado, Juarez Campolina
.







ABSTRACT Elephant grass is an allogamous perennial forage crop with asexual propagation, allowing plant breeders to explore heterosis and develop hybrids. However, selecting parents for diallel crossing schemes is a major hurdle in the development of hybrids. In addition, this perennial crop has several harvests, which increases the dataset size and the complexity of the statistical analyses. Here, we propose a diallel analysis based on linear mixed models with repeatability information to identify parents and hybrids, and the optimum number of harvests. We performed a complete diallel crossing of 11 parents with data from five harvests for morphological traits and two harvests for nutritive value traits. The diallel model with repeatability information aids in the estimation of the genetic effect of diallel analysis to infer the ideal number of harvests and genotype × harvest interaction. We observed that the specific combining ability (SCA) is more critical for morphoagronomic traits, while the general combining ability (GCA) has greater importance for traits related to nutritive value. Furthermore, we detected that five harvests were sufficient for the morphoagronomic traits with a coefficient of determination (R2) of 0.8; however, ten harvests were required for an R2 of 0.9. The model is a promising single-analysis alternative for plant breeders to analyze a diallel with repeated measures and to estimate important parameters without incurring in additional financial costs.
13.
Celebration Time: 20 Years of Brazilian Administration Review
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Guimarães, Tomás de Aquino
; Quintella, Rogério Hermida
; Carneiro, Jorge Manoel Teixeira
; Farias, Salomão Alencar de
; Bellini, Carlo Gabriel Porto
; Garrido, Ivan Lapuente
; Limongi, Ricardo
.







14.
Evaluation of different cut-off points for IgG avidity and IgM in the diagnosis of acute toxoplasmosis in pregnant women participating in a congenital toxoplasmosis screening program
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Laguardia, Michelle Costa
; Carellos, Ericka Viana Machado
; Andrade, Glaucia Manzan Queiroz
; Carneiro, Mariângela
; Januário, José Nélio
; Vitor, Ricardo Wagner de Almeida
.






Revista do Instituto de Medicina Tropical de São Paulo
- Journal Metrics
ABSTRACT The main social impact of toxoplasmosis stems from its ability to be vertically transmitted. Postnatally acquired infection is generally asymptomatic in approximately 70–90% of cases, making diagnosis often dependent on laboratory tests using serological methods to search for anti-T. gondii antibodies. This study aimed to investigate the ability of the VIDAS TOXO IgG avidity and VIDAS TOXO IgM assays to confirm recent toxoplasmosis. In total, 341 pregnant women with suspected acute toxoplasmosis were systematically monitored in the Program for Control of Congenital Toxoplasmosis in Minas Gerais State, Brazil. We conducted an observational analytical-descriptive cross-sectional study and grouped according to clinical and laboratory criteria as having acute or chronic toxoplasmosis. The VIDAS TOXO IgG avidity and VIDAS TOXO IgM assays were evaluated to investigate the capacity to identify acute infection. IgG avidity showed good performance in identifying acute toxoplasmosis when the IgG avidity index was lower than or equal to 0.1. Values greater than or equal to 3.16 according to the TOXO IgM kit were associated with a greater chance of acute infection. These results may contribute to a more adequate diagnosis of acute gestational toxoplasmosis and, consequently, the avoidance of inadequate or unnecessary treatments.
15.
To be or not to B27 positive: implications for the phenotypes of axial spondyloarthritis outcomes. Data from a large multiracial cohort from the Brazilian Registry of Spondyloarthritis
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Resende, Gustavo Gomes
; Saad, Carla Goncalves Schahin
Marques, Claudia Diniz Lopes
Ribeiro, Sandra Lúcia Euzébio
Gavi, Maria Bernadete Renoldi de Oliveira
Yazbek, Michel Alexandre
Marinho, Adriana de Oliveira
Menin, Rita de Cássia
Ochtrop, Manuella Lima Gomes
Soares, Andressa Miozzo
Cavalcanti, Nara Gualberto
Carneiro, Jamille Nascimento
Werner de Castro, Glaucio Ricardo
Fernandes, José Mauro Carneiro
Souza, Elziane da Cruz Ribeiro E
Alvarenga, Corina Quental de Menezes
Vieira, Rejane Maria Rodrigues de Abreu
Machado, Natalia Pereira
Ximenes, Antônio Carlos
Gazzeta, Morgana Ohira
Albuquerque, Cleandro Pires de
Skare, Thelma Larocca
Keiserman, Mauro Waldemar
Kohem, Charles Lubianca
Benacon, Gabriel Sarkis
Rocha, Vítor Florêncio Santos
Lage, Ricardo da Cruz
Malheiro, Olivio Brito
Golebiovski, Rywka Tenenbaum Medeiros
Oliveira, Thauana Luiza
Duque, Ruben Horst
Londe, Ana Carolina
Pinheiro, Marcelo de Medeiros
Sampaio-Barros, Percival Degrava

Abstract Background There is a remarkable variability in the frequency of HLA-B27 positivity in patients with spondyloarthritis (SpA), which may be associated with different clinical presentations worldwide. However, there is a lack of data considering ethnicity and sex on the evaluation of the main clinical and prognostic outcomes in mixed-race populations. The aim of this study was to evaluate the frequency of HLA-B27 and its correlation with disease parameters in a large population of patients from the Brazilian Registry of Spondyloarthritis (RBE). Methods The RBE is a multicenter, observational, prospective cohort that enrolled patients with SpA from 46 centers representing all five geographic regions of Brazil. The inclusion criteria were as follow: (1) diagnosis of axSpA by an expert rheumatologist; (2) age ≥18 years; (3) classification according to ASAS axial. The following data were collected via a standardized protocol: demographic data, disease parameters and treatment historical. Results A total of 1096 patients were included, with 73.4% HLA-B27 positivity and a mean age of 44.4 (±13.2) years. Positive HLA-B27 was significantly associated with male sex, earlier age at disease onset and diagnosis, uveitis, and family history of SpA. Conversely, negative HLA-B27 was associated with psoriasis, higher peripheral involvement and disease activity, worse quality of life and mobility. Conclusions Our data showed that HLA-B27 positivity was associated with a classic axSpA pattern quite similar to that of Caucasian axSpA patients around the world. Furthermore, its absence was associated with peripheral manifestations and worse outcomes, suggesting a relevant phenotypic difference in a highly miscegenated population.
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elocation | elocation |
doi | DOI number |
issn | journal ISSN |
in | SciELO colection code (e.g. scl - Brasil, col - Colômbia) |
use_license | article usage license code |