Results: 40
#1
au:Cardoso, Maria das G.
Filters
Order by
Page
of 3
Next
1.
Rapid and Inexpensive Colorimetric Detection of Total Serum Protein Using Microzone Plates Wax-Printed on Polyester Films
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Oliveira, Karoliny A.
; Cardoso, Thiago M. G.
; Oliveira, Helton F.
; Fioravanti, Maria C. S.
; Coltro, Wendell K. T.
.





This report describes a rapid and inexpensive colorimetric method based on biuret assay for total serum protein analysis using wax printed microzone plates and a desktop scanner. The colorimetric assay was performed in 96-microzone plates fabricated on polyester films through a wax printing protocol. The image scanning mode and the concentration of the biuret reagents were optimized to achieve the highest detectability levels. The best analytical response was obtained using the slide scanning mode as well as 4% CuSO4 and 150 mmol L-1 potassium sodium tartrate solutions. The proposed method offered linear relationship for the bovine serum albumin concentration range between 25 and 200 µmol L-1 with a limit of detection of 9.7 µmol L-1. The colorimetric approach revealed satisfactory precision (relative standard deviation values between 0.6 and 4.4%). The bioanalytical feasibility was demonstrated through the total protein analysis in serum samples collected from dogs previously diagnosed with kidney disease. The total serum protein concentrations varied from 960 ± 19 to 1661 ± 38 µmol L-1 and the achieved values revealed good accordance with those obtained through a reference method. Based on the reported results, wax printed microzone plates have demonstrated simplicity and potential to be adopted as alternative platforms for bioassays.
2.
Promising Nanostructured Materials against Enveloped Virus
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
TOLEDO, GABRIEL G. DE
; TOLEDO, VICTOR H.
; LANFREDI, ALEXANDRE J.C.
; ESCOTE, MARCIA
; CHAMPI, ANA
; SILVA, MARIA CRISTINA C. DA
; NANTES-CARDOSO, ISELI L.
.







Abstract The development of self-disinfectant devices is highly needed to prevent and control infections, mainly caused by virus. In the past years, coronaviruses have been a threat to humanity, causing severe epidemics of respiratory infections such as severe acute respiratory syndrome (SARS), in 2003, and Middle East respiratory syndrome (MERS) in 2012, and presently the SARS-CoV2 is causing the COVID-19 pandemic. Previous studies have demonstrated that surface contamination play a significant role in the spreading of viruses. These studies demonstrated that the production of highly reactive species by copper alloys contributes to rapid elimination of viruses. Nanostructured materials such as semiconductors TiO2, Co3O4 CuO, NiO, and TiO2, and silver nanoparticles can decrease the virus viability on the surfaces when associated with polymers and textiles, especially in conditions of light exposure. In addition, graphene oxide is rising as a promising material for inactivation of viruses due to its capacity of destroying the viral envelope and capsid. The virucidal property of these materials can be enhanced by increasing their functionalization with photosensitizers. The present mini-review brings subsidies for the development of new advanced self-disinfectant materials that can be used in the manufacture of gloves, masks, and a variety of other devices.
3.
Relationship between Electrochemical Parameters, Cytotoxicity Data against Cancer Cells of 3-Thio-Substituted Nor-Beta-Lapachone Derivatives. Implications for Cancer Therapy
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Paiva, Yen G. de
; Silva, Thaissa L.
; Xavier, André F. A.
; Cardoso, Mariana F. C.
; Silva, Fernando C. da
; Silva, Maria F. S.
; Pinheiro, Daniel P.
; Pessoa, Claudia
; Ferreira, Vitor F.
; Goulart, Marilia O. F.
.










Electrochemical methods are powerful in the characterization and design of redox-modulating agents. We, herein, report the electrochemical investigation, in aprotic medium, of eleven synthetic 3-thio-substituted-nor-beta-lapachones, along with the determination of cytotoxic activity and correspondent selectivity index, against several cancer cell lines and one normal cell. Four of the quinones are novel compounds. The redox behavior is representative of two independent systems: the easy reduction of the quinone moiety and, at far more negative potential, the reductive cleavage of the C-S-C bonding; and the anodic part controlled by the oxidation of the sulfur moiety. The compounds have shown relevant cytotoxic activity, with emphasis on 3-phenyl-thio-2,2-dimethyl-2,3-dihydronaphtho[1,2-b]furan-4,5-dione (compound 2), which mechanism of molecular action was shown to be related to reactive oxygen species (ROS) release. Despite the absence of a linear correlation, there is a trend: the majority of the thionaphthoquinones, with values of first wave reduction potential, less negative than -0.65 V, were active. The less electrophilic compound (3-(cyclohexylthio)-2,2-dimethyl-2,3-dihydronaphtho[1,2-b]furan-4,5-dione, cyclohexyl derivative) is also the less cytotoxic toward cancer cells. Agents containing chalcogens and quinones can be used to attack entities with a disturbed redox balance.
https://doi.org/10.21577/0103-5053.20180248
741 downloads
4.
Development, Optimization and Validation of a GC Method by Polarity Phase Constants and Statistical Design of Experiments for the Determination of Monoterpenes in Alpinia zerumbet Essential Oil
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Cardoso, Igor C.
; Nakamura, Marcos J.
; Correia, Virginia G.
; Pereira, Henrique M. G.
; Behrens, Maria D.
; Tappin, Marcelo R. R.
.






Journal of the Brazilian Chemical Society
- Journal Metrics
In this report, a rapid and selective analytical method for the determination of monoterpenes in Alpinia zerumbet essential oil (AZEO) by gas chromatography (GC) flame ionization detection (FID) was developed, optimized and validated. The suitability of six different capillary columns was investigated by polarity phase constants calculated based on the methodology proposed by Rohrschneider and McReynolds. The most suitable column was then used in a central composite design applying the following GC factors to investigate responses based on peak resolutions and analysis time: initial oven temperature, heating rate and carrier gas flow rate. The optimized method has initial oven temperature of 60 ºC, heating rate of 5.1 ºC min-1 and flow rate of 1.0 mL min-1 using the DB-35 capillary column. The validation acceptance criteria were met in all cases. The method was successfully applied for the quantification of major monoterpenes found in AZEO in different samples of Alpinia zerumbet.
https://doi.org/10.21577/0103-5053.20180102
1376 downloads
5.
Development of carpels and ovules in Dialypetalanthus fuscescens Kuhlm. (Rubiaceae): an enigmatic taxon
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Figueiredo, Rogério da Costa
; Vieira, Ricardo Cardoso
; Mariath, Jorge Ernesto de Araújo
; Moço, Maria Cecilia de Chiara
; Toni, Karen L. G. De
.





ABSTRACT Dialypetalanthus is a monospecific genus that occurs in the Amazon Basin of Brazil, Bolivia and Peru and occupies a controversial position among the Rubiaceae. We continue this taxonomic discussion with the overall aim of clarifying the systematic position of D. fuscescens within the Rubiaceae. To accomplish this, we analyzed the ontogeny of its gynoecium, in particular the floral meristem, as well as the development of the carpels and cauline placentation. Gynosporogenesis and the differentiation of the carpellary septa and ovules were also described. Dialypetalanthus fuscescens was classified according to evolutionary diagrams found in the literature. The following characteristics were observed in D. fuscescens: 1) permanence of the floral meristem in the central basal part of the early flower bud; 2) dual origin of carpellary septum; 3) trizonate ovular primordia with only one fertile gynospore per ovule; and 4) cellular proliferation in the chalazal region. Embryological results confirm the classification of D. fuscescens in the subfamily Ixoroideae. These results are distinct from any others previously proposed in the evolutionary diagram. Therefore, we conclude that this study has presented evidence strongly suggesting that Dialypetalanthus possesses new morphological-type of ovule we refer to as the Dialypetalanthus-type.
https://doi.org/10.1590/0102-33062016abb0456
1581 downloads
6.
A diagnostic approach for neurodegeneration with brain iron accumulation: clinical features, genetics and brain imaging
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Salomão, Rubens Paulo Araújo
; Pedroso, José Luiz
; Gama, Maria Thereza Drumond
; Dutra, Lívia Almeida
; Maciel, Ricardo Horta
; Godeiro-Junior, Clécio
; Chien, Hsin Fen
; Teive, Hélio A. G.
; Cardoso, Francisco
; Barsottini, Orlando G. P.
.










ABSTRACT Neurodegeneration with brain iron accumulation (NBIA) represents a heterogeneous and complex group of inherited neurodegenerative diseases, characterized by excessive iron accumulation, particularly in the basal ganglia. Common clinical features of NBIA include movement disorders, particularly parkinsonism and dystonia, cognitive dysfunction, pyramidal signs, and retinal abnormalities. The forms of NBIA described to date include pantothenase kinase-associated neurodegeneration (PKAN), phospholipase A2 associated neurodegeneration (PLAN), neuroferritinopathy, aceruloplasminemia, beta-propeller protein-associated neurodegeneration (BPAN), Kufor-Rakeb syndrome, mitochondrial membrane protein-associated neurodegeneration (MPAN), fatty acid hydroxylase-associated neurodegeneration (FAHN), coenzyme A synthase protein-associated neurodegeneration (CoPAN) and Woodhouse-Sakati syndrome. This review is a diagnostic approach for NBIA cases, from clinical features and brain imaging findings to the genetic etiology.
RESUMO A neurodegeneração com acúmulo cerebral de ferro (sigla em inglês NBIA) representa um grupo heterogêneo e complexo de doenças neurodegenerativas hereditárias, caracterizada pelo acúmulo cerebral de ferro, especialmente nos núcleos da base. O quadro clínico das NBIAs em geral inclui distúrbios do movimento, particularmente parkinsonismo e distonia, disfunção cognitiva, sinais piramidais e anormalidades da retina. As formas de NBIA descritas até o momento incluem neurodegeneração associada a pantothenase kinase (PKAN), neurodegeneração associada a phospholipase A2 (PLAN), neuroferritinopatia, aceruloplasminemia, neurodegeneração associada a beta-propeller protein (BPAN), síndrome de Kufor-Rakeb, neurodegeneração associada a mitochondrial membrane protein (MPAN), neurodegeneração associada a “fatty acid hydroxylase” (FAHN), neurodegeneração associada a coenzyme A synthase protein (CoPAN) e síndrome de Woodhouse-Sakati. Esta revisão é uma orientação para o diagnóstico das NBIAs, partindo das características clínicas e achados de neuroimagem, até a etiologia genética.
https://doi.org/10.1590/0004-282X20160080
18179 downloads
7.
Aminonaphthoquinone Mannich Bases Derived from Lawsone and Their Copper(II) Complex Derivatives: Synthesis and Potential Cholinesterase Inhibitors as Identified by On-flow Assay
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Vilela, Adriana F. L.
; Frugeri, Bárbara M.
; Sarria, André L. F.
; Kitamura, Rodrigo O. S.
; Fernandes, João B.
; Silva, Maria F. G. F.
; Cass, Quezia B.
; Cardoso, Carmen L.
.








A new series of Mannich bases derived from 2-hydroxy-1,4-naphthoquinone (lawsone), substituted benzaldehydes and two primary amines, and their Cu2+ complexes were synthesized and evaluated for their potential as selective cholinesterase inhibitors (ChEIs). Immobilized capillary enzyme reactors (ICERs) bearing butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) were used not only for the on-flow screening assay but also for determining the inhibitory potency and equilibrium binding constants of the lead inhibitors. Eight copper complexes were identified and characterized as potent reversible and selective ChEIs with inhibitory potencies (IC50) and constants of inhibition (Ki) ranging from 1.24 to 11.5 µmol L-1. One of the compounds was particularly promising, showing IC50 and Ki values of 1.24 ± 0.01 and 1.06 ± 0.01 µmol L-1, respectively, for huAChE. These values were lower than those for the standard inhibitor galanthamine (IC50 = 206 ± 30.0 and Ki = 126 ± 18.0 µmol L-1). Even though, it is showing noncompetitive inhibition of huAChE and linear mixed-type inhibition of eeAChE. These complexes showed a promising cholinesterase inhibitory activity and can be used as model inhibitors.
https://doi.org/10.5935/0103-5053.20150281
5982 downloads
8.
Update of the Brazilian floristic list of Algae and Cyanobacteria
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Menezes, Mariângela
; Bicudo, Carlos E. M.
; Moura, Carlos W. N.
; Alves, Aigara M.
; Santos, Alana A.
; Pedrini, Alexandre de G.
; Araújo, Andréa
; Tucci, Andrea
; Fajar, Aurelio
; Malone, Camila
; Kano, Cecília H.
; Sant'Anna, Célia L.
; Branco, Ciro Z.
; Odebrecht, Clarisse
; Peres, Cleto K.
; Neuhaus, Emanuel B.
; Eskinazi-Leça, Enide
; Aquino, Eveline
; Nauer, Fabio
; Santos, Gabriel N.
; Amado Filho, Gilberto M.
; Lyra, Goia M.
; Borges, Gyslaine C.P.
; Costa, Iara O.
; Nogueira, Ina de S.
; Oliveira, Ivania B.
; Paula, Joel. C.de
; Nunes, José M. de C.
; Lima, Jucicleide C.
; Santos, Kleber R.S.
; Ferreira, Leandro C.
; Gestinari, Lísia M.S.
; Cardoso, Luciana S.
; Figueiredo, Marcia A.O.
; Silva, Marcos H.
; Barreto, Maria B.B.B.
; Henriques, Maria C.O.
; Cunha, Maria da G.G.S.
; Bandeira-Pedrosa, Maria E.
; Oliveira-Carvalho, Maria F.
; Széchy, Maria T.M.
; Azevedo, Maria T.P.
; Oliveira, Mariana C. de
; Cabezudo, Mariê M.
; Santiago, Marilene F.
; Bergesh, Marli
; Fujii, Mutuê T.
; Bueno, Norma C.
; Necchi Jr., Orlando
; Jesus, Priscila B.
; Bahia, Ricardo G.
; Khader, Samir
; Alves-da-Silva, Sandra M.
; Guimarães, Silvia M.P.B.
; Pereira, Sonia M.B.
; Caires, Taiara A.
; Meurer, Thamis
; Cassano, Valéria
; Werner, Vera R.
; Gama Jr., Watson A. da
; Silva, Weliton J. da
.





























































Abstract An updated synthesis of cyanobacteria and algae information is presented for Brazil aiming to refine the data gathered to date and evaluate the progress of the biodiversity knowledge about these organisms in the country since the publication of the Catálogo de Plantas e Fungos do Brasil. The results of 2015 showed an increase of 1,250 species (35.7%) when compared to 2010, reaching a total of 4,747 species. The most diverse classes in species number were the Bacillariophyceae, Conjugatophyceae, Florideophyceae, Cyanophyceae, Dinophyceae and Euglenophyceae. Bacillariophyceae and Cyanophyceae had the highest increase in species number in the five-year interval. The Southeast and South regions were the most diverse, however, the Northeast, with the states of Piauí and Sergipe, and the Central-west region, with Mato Grosso, Goiás and Distrito Federal, also stood out in the national algal biodiversity scenario. Despite the shortage of taxonomists and limited infrastructure, the results showed a significant improvement in the knowledge regarding the diversity of cyanobacteria and algae in the country during the study period, starting to even out regional geographical differences caused by subsampling.
Resumo Apresenta-se uma síntese atualizada de informações sobre algas no Brasil objetivando refinar os dados reunidos até o presente, bem como avaliar os avanços sobre o conhecimento da diversidade de algas no país desde a publicação do Catálogo de Plantas e Fungos do Brasil. Os resultados de 2015 mostraram um acréscimo de 1.250 espécies (35.7%) a um total de 4.747 em relação a 2010. As classes mais diversas em número de espécies foram Bacillariophyceae, Conjugatophyceae, Florideophyceae, Cyanophyceae, Dinophyceae e Euglenophyceae. Bacillariophyceae e Cyanophyceae tiveram o maior acréscimo de espécies no intervalo de cinco anos. A região Sudeste e Sul foram as mais diversas, porém, as regiões Nordeste com os estados do Piauí e Sergipe e Centro-Oeste com os estados de Mato Grosso, Goiás e Distrito Federal destacaram-se no cenário da biodiversidade nacional. Apesar da escassez de taxonomistas e da infraestrutura limitada, os resultados obtidos evidenciaram um avanço significativo no conhecimento da diversidade de algas no país nesse período de cinco anos, iniciando uma mudança quanto as diferenças geográficas regionais.
https://doi.org/10.1590/2175-7860201566408
4865 downloads
9.
Growing knowledge: an overview of Seed Plant diversity in Brazil
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Zappi, Daniela C.
; Filardi, Fabiana L. Ranzato
; Leitman, Paula
; Souza, Vinícius C.
; Walter, Bruno M.T.
; Pirani, José R.
; Morim, Marli P.
; Queiroz, Luciano P.
; Cavalcanti, Taciana B.
; Mansano, Vidal F.
; Forzza, Rafaela C.
; Abreu, Maria C.
; Acevedo-Rodríguez, Pedro
; Agra, Maria F.
; Almeida Jr., Eduardo B.
; Almeida, Gracineide S.S.
; Almeida, Rafael F.
; Alves, Flávio M.
; Alves, Marccus
; Alves-Araujo, Anderson
; Amaral, Maria C.E.
; Amorim, André M.
; Amorim, Bruno
; Andrade, Ivanilza M.
; Andreata, Regina H.P.
; Andrino, Caroline O.
; Anunciação, Elisete A.
; Aona, Lidyanne Y.S.
; Aranguren, Yani
; Aranha Filho, João L.M.
; Araújo, Andrea O.
; Araújo, Ariclenes A.M.
; Araújo, Diogo
; Arbo, María M.
; Assis, Leandro
; Assis, Marta C.
; Assunção, Vivian A.
; Athiê-Souza, Sarah M.
; Azevedo, Cecilia O.
; Baitello, João B.
; Barberena, Felipe F.V.A.
; Barbosa, Maria R.V.
; Barros, Fábio
; Barros, Lucas A.V.
; Barros, Michel J.F.
; Baumgratz, José F.A.
; Bernacci, Luis C.
; Berry, Paul E.
; Bigio, Narcísio C.
; Biral, Leonardo
; Bittrich, Volker
; Borges, Rafael A.X.
; Bortoluzzi, Roseli L.C.
; Bove, Cláudia P.
; Bovini, Massimo G.
; Braga, João M.A.
; Braz, Denise M.
; Bringel Jr., João B.A.
; Bruniera, Carla P.
; Buturi, Camila V.
; Cabral, Elza
; Cabral, Fernanda N.
; Caddah, Mayara K.
; Caires, Claudenir S.
; Calazans, Luana S.B.
; Calió, Maria F.
; Camargo, Rodrigo A.
; Campbell, Lisa
; Canto-Dorow, Thais S.
; Carauta, Jorge P.P.
; Cardiel, José M.
; Cardoso, Domingos B.O.S.
; Cardoso, Leandro J.T.
; Carneiro, Camila R.
; Carneiro, Cláudia E.
; Carneiro-Torres, Daniela S.
; Carrijo, Tatiana T.
; Caruzo, Maria B.R.
; Carvalho, Maria L.S.
; Carvalho-Silva, Micheline
; Castello, Ana C.D.
; Cavalheiro, Larissa
; Cervi, Armando C.
; Chacon, Roberta G.
; Chautems, Alain
; Chiavegatto, Berenice
; Chukr, Nádia S.
; Coelho, Alexa A.O.P.
; Coelho, Marcus A.N.
; Coelho, Rubens L.G.
; Cordeiro, Inês
; Cordula, Elizabeth
; Cornejo, Xavier
; Côrtes, Ana L.A.
; Costa, Andrea F.
; Costa, Fabiane N.
; Costa, Jorge A.S.
; Costa, Leila C.
; Costa-e-Silva, Maria B.
; Costa-Lima, James L.
; Cota, Maria R.C.
; Couto, Ricardo S.
; Daly, Douglas C.
; De Stefano, Rodrigo D.
; De Toni, Karen
; Dematteis, Massimiliano
; Dettke, Greta A.
; Di Maio, Fernando R.
; Dórea, Marcos C.
; Duarte, Marília C.
; Dutilh, Julie H.A.
; Dutra, Valquíria F.
; Echternacht, Lívia
; Eggers, Lilian
; Esteves, Gerleni
; Ezcurra, Cecilia
; Falcão Junior, Marcus J.A.
; Feres, Fabíola
; Fernandes, José M.
; Ferreira, D.M.C.
; Ferreira, Fabrício M.
; Ferreira, Gabriel E.
; Ferreira, Priscila P.A.
; Ferreira, Silvana C.
; Ferrucci, Maria S.
; Fiaschi, Pedro
; Filgueiras, Tarciso S.
; Firens, Marcela
; Flores, Andreia S.
; Forero, Enrique
; Forster, Wellington
; Fortuna-Perez, Ana P.
; Fortunato, Reneé H.
; Fraga, Cléudio N.
; França, Flávio
; Francener, Augusto
; Freitas, Joelcio
; Freitas, Maria F.
; Fritsch, Peter W.
; Furtado, Samyra G.
; Gaglioti, André L.
; Garcia, Flávia C.P.
; Germano Filho, Pedro
; Giacomin, Leandro
; Gil, André S.B.
; Giulietti, Ana M.
; A.P.Godoy, Silvana
; Goldenberg, Renato
; Gomes da Costa, Géssica A.
; Gomes, Mário
; Gomes-Klein, Vera L.
; Gonçalves, Eduardo Gomes
; Graham, Shirley
; Groppo, Milton
; Guedes, Juliana S.
; Guimarães, Leonardo R.S.
; Guimarães, Paulo J.F.
; Guimarães, Elsie F.
; Gutierrez, Raul
; Harley, Raymond
; Hassemer, Gustavo
; Hattori, Eric K.O.
; Hefler, Sonia M.
; Heiden, Gustavo
; Henderson, Andrew
; Hensold, Nancy
; Hiepko, Paul
; Holanda, Ana S.S.
; Iganci, João R.V.
; Imig, Daniela C.
; Indriunas, Alexandre
; Jacques, Eliane L.
; Jardim, Jomar G.
; Kamer, Hiltje M.
; Kameyama, Cíntia
; Kinoshita, Luiza S.
; Kirizawa, Mizué
; Klitgaard, Bente B.
; Koch, Ingrid
; Koschnitzke, Cristiana
; Krauss, Nathália P.
; Kriebel, Ricardo
; Kuntz, Juliana
; Larocca, João
; Leal, Eduardo S.
; Lewis, Gwilym P.
; Lima, Carla T.
; Lima, Haroldo C.
; Lima, Itamar B.
; Lima, Laíce F.G.
; Lima, Laura C.P.
; Lima, Leticia R.
; Lima, Luís F.P.
; Lima, Rita B.
; Lírio, Elton J.
; Liro, Renata M.
; Lleras, Eduardo
; Lobão, Adriana
; Loeuille, Benoit
; Lohmann, Lúcia G.
; Loiola, Maria I.B.
; Lombardi, Julio A.
; Longhi-Wagner, Hilda M.
; Lopes, Rosana C.
; Lorencini, Tiago S.
; Louzada, Rafael B.
; Lovo, Juliana
; Lozano, Eduardo D.
; Lucas, Eve
; Ludtke, Raquel
; Luz, Christian L.
; Maas, Paul
; Machado, Anderson F.P.
; Macias, Leila
; Maciel, Jefferson R.
; Magenta, Mara A.G.
; Mamede, Maria C.H.
; Manoel, Evelin A.
; Marchioretto, Maria S.
; Marques, Juliana S.
; Marquete, Nilda
; Marquete, Ronaldo
; Martinelli, Gustavo
; Martins da Silva, Regina C.V.
; Martins, Ângela B.
; Martins, Erika R.
; Martins, Márcio L.L.
; Martins, Milena V.
; Martins, Renata C.
; Matias, Ligia Q.
; Maya-L., Carlos A.
; Mayo, Simon
; Mazine, Fiorella
; Medeiros, Debora
; Medeiros, Erika S.
; Medeiros, Herison
; Medeiros, João D.
; Meireles, José E.
; Mello-Silva, Renato
; Melo, Aline
; Melo, André L.
; Melo, Efigênia
; Melo, José I.M.
; Menezes, Cristine G.
; Menini Neto, Luiz
; Mentz, Lilian A.
; Mezzonato, A.C.
; Michelangeli, Fabián A.
; Milward-de-Azevedo, Michaele A.
; Miotto, Silvia T.S.
; Miranda, Vitor F.O.
; Mondin, Cláudio A.
; Monge, Marcelo
; Monteiro, Daniele
; Monteiro, Raquel F.
; Moraes, Marta D.
; Moraes, Pedro L.R.
; Mori, Scott A.
; Mota, Aline C.
; Mota, Nara F.O.
; Moura, Tania M.
; Mulgura, Maria
; Nakajima, Jimi N.
; Nardy, Camila
; Nascimento Júnior, José E.
; Noblick, Larry
; Nunes, Teonildes S.
; O'Leary, Nataly
; Oliveira, Arline S.
; Oliveira, Caetano T.
; Oliveira, Juliana A.
; Oliveira, Luciana S.D.
; Oliveira, Maria L.A.A.
; Oliveira, Regina C.
; Oliveira, Renata S.
; Oliveira, Reyjane P.
; Paixão-Souza, Bruno
; Parra, Lara R.
; Pasini, Eduardo
; Pastore, José F.B.
; Pastore, Mayara
; Paula-Souza, Juliana
; Pederneiras, Leandro C.
; Peixoto, Ariane L.
; Pelissari, Gisela
; Pellegrini, Marco O.O.
; Pennington, Toby
; Perdiz, Ricardo O.
; Pereira, Anna C.M.
; Pereira, Maria S.
; Pereira, Rodrigo A.S.
; Pessoa, Clenia
; Pessoa, Edlley M.
; Pessoa, Maria C.R.
; Pinto, Luiz J.S.
; Pinto, Rafael B.
; Pontes, Tiago A.
; Prance, Ghillean T.
; Proença, Carolyn
; Profice, Sheila R.
; Pscheidt, Allan C.
; Queiroz, George A.
; Queiroz, Rubens T.
; Quinet, Alexandre
; Rainer, Heimo
; Ramos, Eliana
; Rando, Juliana G.
; Rapini, Alessandro
; Reginato, Marcelo
; Reis, Ilka P.
; Reis, Priscila A.
; Ribeiro, André R.O.
; Ribeiro, José E.L.S.
; Riina, Ricarda
; Ritter, Mara R.
; Rivadavia, Fernando
; Rocha, Antônio E.S.
; Rocha, Maria J.R.
; Rodrigues, Izabella M.C.
; Rodrigues, Karina F.
; Rodrigues, Rodrigo S.
; Rodrigues, Rodrigo S.
; Rodrigues, Vinícius T.
; Rodrigues, William
; Romaniuc Neto, Sérgio
; Romão, Gerson O.
; Romero, Rosana
; Roque, Nádia
; Rosa, Patrícia
; Rossi, Lúcia
; Sá, Cyl F.C.
; Saavedra, Mariana M.
; Saka, Mariana
; Sakuragui, Cássia M.
; Salas, Roberto M.
; Sales, Margareth F.
; Salimena, Fatima R.G.
; Sampaio, Daniela
; Sancho, Gisela
; Sano, Paulo T.
; Santos, Alessandra
; Santos, Élide P.
; Santos, Juliana S.
; Santos, Marianna R.
; Santos-Gonçalves, Ana P.
; Santos-Silva, Fernanda
; São-Mateus, Wallace
; Saraiva, Deisy P.
; Saridakis, Dennis P.
; Sartori, Ângela L.B.
; Scalon, Viviane R.
; Schneider, Ângelo
; Sebastiani, Renata
; Secco, Ricardo S.
; Senna, Luisa
; Senna-Valle, Luci
; Shirasuna, Regina T.
; Silva Filho, Pedro J.S.
; Silva, Anádria S.
; Silva, Christian
; Silva, Genilson A.R.
; Silva, Gisele O.
; Silva, Márcia C.R.
; Silva, Marcos J.
; Silva, Marcos J.
; Silva, Otávio L.M.
; Silva, Rafaela A.P.
; Silva, Saura R.
; Silva, Tania R.S.
; Silva-Gonçalves, Kelly C.
; Silva-Luz, Cíntia L.
; Simão-Bianchini, Rosângela
; Simões, André O.
; Simpson, Beryl
; Siniscalchi, Carolina M.
; Siqueira Filho, José A.
; Siqueira, Carlos E.
; Siqueira, Josafá C.
; Smith, Nathan P.
; Snak, Cristiane
; Soares Neto, Raimundo L.
; Soares, Kelen P.
; Soares, Marcos V.B.
; Soares, Maria L.
; Soares, Polyana N.
; Sobral, Marcos
; Sodré, Rodolfo C.
; Somner, Genise V.
; Sothers, Cynthia A.
; Sousa, Danilo J.L.
; Souza, Elnatan B.
; Souza, Élvia R.
; Souza, Marcelo
; Souza, Maria L.D.R.
; Souza-Buturi, Fátima O.
; Spina, Andréa P.
; Stapf, María N.S.
; Stefano, Marina V.
; Stehmann, João R.
; Steinmann, Victor
; Takeuchi, Cátia
; Taylor, Charlotte M.
; Taylor, Nigel P.
; Teles, Aristônio M.
; Temponi, Lívia G.
; Terra-Araujo, Mário H.
; Thode, Veronica
; Thomas, W.Wayt
; Tissot-Squalli, Mara L.
; Torke, Benjamin M.
; Torres, Roseli B.
; Tozzi, Ana M.G.A.
; Trad, Rafaela J.
; Trevisan, Rafael
; Trovó, Marcelo
; Valls, José F.M.
; Vaz, Angela M.S.F.
; Versieux, Leonardo
; Viana, Pedro L.
; Vianna Filho, Marcelo D.M.
; Vieira, Ana O.S.
; Vieira, Diego D.
; Vignoli-Silva, Márcia
; Vilar, Thaisa
; Vinhos, Franklin
; Wallnöfer, Bruno
; Wanderley, Maria G.L.
; Wasshausen, Dieter
; Watanabe, Maurício T.C.
; Weigend, Maximilian
; Welker, Cassiano A.D.
; Woodgyer, Elizabeth
; Xifreda, Cecilia C.
; Yamamoto, Kikyo
; Zanin, Ana
; Zenni, Rafael D.
; Zickel, Carmem S
.





















































































































































































































































































































































































































































Abstract An updated inventory of Brazilian seed plants is presented and offers important insights into the country's biodiversity. This work started in 2010, with the publication of the Plants and Fungi Catalogue, and has been updated since by more than 430 specialists working online. Brazil is home to 32,086 native Angiosperms and 23 native Gymnosperms, showing an increase of 3% in its species richness in relation to 2010. The Amazon Rainforest is the richest Brazilian biome for Gymnosperms, while the Atlantic Rainforest is the richest one for Angiosperms. There was a considerable increment in the number of species and endemism rates for biomes, except for the Amazon that showed a decrease of 2.5% of recorded endemics. However, well over half of Brazillian seed plant species (57.4%) is endemic to this territory. The proportion of life-forms varies among different biomes: trees are more expressive in the Amazon and Atlantic Rainforest biomes while herbs predominate in the Pampa, and lianas are more expressive in the Amazon, Atlantic Rainforest, and Pantanal. This compilation serves not only to quantify Brazilian biodiversity, but also to highlight areas where there information is lacking and to provide a framework for the challenge faced in conserving Brazil's unique and diverse flora.
Resumo Um levantamento atualizado das plantas com sementes e análises relevantes acerca desta biodiversidade são apresentados. Este trabalho se iniciou em 2010 com a publicação do Catálogo de Plantas e Fungos e, desde então vem sendo atualizado por mais de 430 especialistas trabalhando online. O Brasil abriga atualmente 32.086 espécies nativas de Angiospermas e 23 espécies nativas de Gimnospermas e estes novos dados mostram um aumento de 3% da riqueza em relação a 2010. A Amazônia é o Domínio Fitogeográfico com o maior número de espécies de Gimnospermas, enquanto que a Floresta Atlântica possui a maior riqueza de Angiospermas. Houve um crescimento considerável no número de espécies e nas taxas de endemismo para a maioria dos Domínios (Caatinga, Cerrado, Floresta Atlântica, Pampa e Pantanal), com exceção da Amazônia que apresentou uma diminuição de 2,5% de endemicidade. Entretanto, a maior parte das plantas com sementes que ocorrem no Brasil (57,4%) é endêmica deste território. A proporção de formas de vida varia de acordo com os diferentes Domínios: árvores são mais expressivas na Amazônia e Floresta Atlântica do que nos outros biomas, ervas são dominantes no Pampa e as lianas apresentam riqueza expressiva na Amazônia, Floresta Atlântica e Pantanal. Este trabalho não só quantifica a biodiversidade brasileira, mas também indica as lacunas de conhecimento e o desafio a ser enfrentado para a conservação desta flora.
https://doi.org/10.1590/2175-7860201566411
33340 downloads
10.
Viral suppression and adherence among HIV-infected children and adolescents on antiretroviral therapy: results of a multicenter study
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Cruz, Maria L.S.
; Cardoso, Claudete A.A.
; Darmont, Mariana Q.
; Souza, Edvaldo
; Andrade, Solange D.
; D'Al Fabbro, Marcia M.
; Fonseca, Rosana
; Bellido, Jaime G.
; Monteiro, Simone S.
; Bastos, Francisco I.
.










OBJECTIVE: To evaluate treatment adherence among perinatally-infected pediatric human immunodeficiency virus (HIV) patients followed in pediatric centers in Brazil. METHODS: This was a cross-sectional multicenter study. Medical records were reviewed and adherence scale, assessment of caregivers' quality of life (WHOQOL-BREF), anxiety, depression, and alcohol/substances use/abuse were assessed. Outcomes included self-reported 100% adherence in the last three days and HIV viral load (VL) < 50 copies/mL. Statistical analyses included contingency tables and respective statistics, and multivariable logistic regression. RESULTS: 260 subjects were enrolled: 78% children and 22% adolescents; 93% of caregivers for the children and 77% of adolescents reported 100% adherence; 57% of children and 49% of adolescents had VL < 50 copies/mL. In the univariate analyses, HIV diagnosis for screening due to maternal infection, lower caregiver scores for anxiety, and higher scores in physical and psychological domains of WHOQOL-BREF were associated with 100% adherence. Shorter intervals between pharmacy visits were associated with VL < 50 copies/mL (p ≤ 0.01). Multivariable regression demonstrated that caregivers who did not abuse alcohol/other drugs (OR = 0.49; 95% CI: 0.27-0.89) and median interval between pharmacy visits < 33 days (OR = 0.97; 95% CI: 0.95-0.98) were independently associated with VL < 50 copies/mL; whereas lower caregiver scores for anxiety (OR = 2.57; 95% CI: 1.27-5.19) and children's HIV diagnosis for screening due to maternal infection (OR = 2.25; 95% CI: 1.12-4.50) were found to be independently associated with 100% adherence. CONCLUSIONS: Pediatric HIV programs should perform routine assessment of caregivers' quality of life, and anxiety and depression symptoms. In this setting, pharmacy records are essential to help identify less-than-optimal adherence.
OBJETIVO: Avaliar a adesão ao tratamento antirretroviral entre portadores de HIV acompanhados em centros pediátricos. MÉTODOS: Trata-se de estudo transversal multicêntrico. Os prontuários ambulatoriais foram revistos e aplicadas escala de adesão, avaliação de qualidade de vida (WHOQOL-BREF), ansiedade, depressão e uso indevido de álcool/substâncias entre cuidadores. Os desfechos incluíram autorrelato 100% de adesão nos últimos três dias e carga viral do HIV (CV) < 50 cópias/mL. RESULTADOS: 260 indivíduos foram incluídos, 79% crianças e 21% adolescentes; 93% das crianças e 77% dos adolescentes relataram 100% de adesão; 57% das crianças e 49% dos adolescentes tinham CV < 50 cópias /mL. Na análise univariada, diagnóstico do HIV por triagem devido à infecção materna, cuidador com pontuação menor para ansiedade e maior nos domínios físico e psicológico do WHOQOL-BREF se mostraram independentemente associados a 100% de adesão. Intervalos mais curtos entre visitas de farmácia foram associados com CV < 50 cópias /mL (p ≤ 0,01). Regressão multivariada mostrou que os cuidadores sem abuso de álcool/outras drogas (OR = 0,49; IC95% 0,27-0,89) e o intervalo médio entre visitas de farmácia < 33 dias (OR = 0,97; IC95% 0,95-0,98) foram associados com CV < 50 cópias/mL; cuidador com menores escores para ansiedade (OR = 2,57; IC95% 1,27-5,19) e diagnóstico de crianças por triagem devido à infecção materna (OR = 2,25; IC95% 1,12-4,50) foram associados com 100% de adesão. CONCLUSÕES: Programas de HIV pediátrico devem avaliar qualidade de vida e sintomas de ansiedade e depressão dos cuidadores. Registros de farmácia são essenciais na identificação de adesão insatisfatória.
https://doi.org/10.1016/j.jped.2014.04.007
5998 downloads
11.
Relação da idade na presença de bactérias resistentes a antimicrobianos em rebanhos leiteiros no Rio Grande do Sul
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Santiago-Neto, Waldemir
; Machado, Gustavo
; Paim, Daniel S.
; Campos, Thais de
; Brito, Maria A.V.P.
; Cardoso, Marisa R.I.
; Corbellini, Luís G.
.







Bovine mastitis is an important disease in dairy cattle due to its high incidence and economic losses associated mainly with reduced milk production and treatment costs. The use of antimicrobials to treat clinical cases and at dry off raises the concern of selection of resistant bacterial strains. This may also reflect on public health, since resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), may be transmitted to humans by direct contact with infected animals or by dairy products. The resistance of bacteria to antimicrobials has risen, in general, due to ineffective therapy. Studies in Brazil with non-random samples show increase in resistance pattern, mainly in S. aureus. The exposition to repeated antimicrobial treatment throughout the consecutive lactations of cows may be a predisposing factor to development of antimicrobial resistance in bacteria that infect the udder. Thus, the aim of this study was to determine the possible causal association between antimicrobial resistance in bacteria isolated from bovine udder milk and animal data such as age and lactation period. Milk samples were collected from 21 randomly selected dairy herds from Rio Grande do Sul, southernmost Brazilian state, from the target population of 1656 semi-intensive dairy farms, stratified by her size. The sample unit was considered the bacteria, and for the prevalence estimation a frequency of 35% Staphylococcus sp. penicillin resistant; an absolute precision of 12%; and 90% confidence level were used. Bacteria were isolated from composite milk samples obtained from all quarters of each cow after discarding the initial three or four streams of milk. To access potential risk factors, animal characteristics were obtained through an interview with the producers. Laboratory tests were done according to National Mastitis Council recommendations. A total of 242 isolates was obtained from 195 cows out of 251 cows sampled. The prevalence of animal infections was described in groups according to the epidemiological profile: environmental, contagious and other bacteria. These were 57.3%, 26.3% and 11.2%, respectively of the sampled animals. Antimicrobial susceptibility tests against 12 different antimicrobials were performed in 159 isolates. Altogether, 30% of the isolates tested showed resistance to at least three different antimicrobial groups and were classified as multidrug-resistant. Higher frequencies of resistance were observed against ampicillin to coagulase-negative staphylococci, followed by erythromycin to coagulase-positive staphylococci and tetracycline to streptococci. The logistic regression analysis showed a significant relationship between age of the cows and presence of multidrug-resistant coagulase-positive staphylococci and distribution of different class of bacteria, suggesting a competition dynamic throughout the ages (p < 0.05). Animals with three to four years old had 13.7 times more chances (IC95% 1.4 - 130.2; p = 0,02) to have multidrug-resistant coagulase-positive staphylococci compared to those with two to three years. Time of exposure to infectious agents and consequent therapies suggests a greater chance of udder's colonization by resistant pathogens due to repeatedly selection pressure during lifetime.
A mastite bovina é uma doença importante na bovinocultura de leite, devido à sua alta incidência e perdas econômicas associadas principalmente com a produção de leite reduzida e aos custos do tratamento. O uso de antimicrobianos para o tratamento de casos clínicos e no período seco tem levantado preocupações quanto à seleção de cepas bacterianas resistentes. Isso também pode refletir na saúde pública, uma vez que bactérias resistentes, como o Staphylococcus aureus meticilina-resistente (MRSA), podem ser transmitidas aos seres humanos por contato direto com animais infectados ou produtos lácteos. A resistência das bactérias aos agentes antimicrobianos aumentou, em geral, devido a tratamentos ineficazes. Estudos realizados no Brasil com amostras não planejadas mostram aumento no padrão de resistência, principalmente em S. aureus. A exposição ao tratamento antimicrobiano repetido ao longo das lactações consecutivas de vacas pode ser um fator predisponente para o desenvolvimento da resistência antimicrobiana em bactérias que infectam o úbere. Assim, o objetivo deste estudo foi determinar a possível associação causal entre resistência antimicrobiana em bactérias isoladas a partir do leite bovino e dados como idade e período de lactação. As amostras de leite foram coletadas de 21 rebanhos leiteiros do Rio Grande do Sul, Brasil, selecionados aleatoriamente a partir da população-alvo de 1.656 explorações leiteiras semi-intensivas, estratificada por tamanho do rebanho. A bactéria foi considerada a unidade amostral, e para a estimativa de prevalência foram utilizados os seguintes parâmetros: uma frequência de 35% de Staphylococcus sp. resistentes à penicilina; um nível de confiança de 90%; e uma precisão absoluta de 12%. As bactérias foram isoladas de amostras de leite compostas de todos os quartos mamários de cada vaca após descartar os primeiros três ou quatro jatos de leite. Para acessar os potenciais fatores de risco, características dos animais foram obtidas através de uma entrevista com os produtores. Os exames laboratoriais foram realizados de acordo com as recomendações do National Mastitis Council. Um total de 242 isolados foi obtido de 195 vacas a partir da amostra do rebanho total (251 vacas). A prevalência de infecções foi descrita em grupos de acordo com o perfil epidemiológico: bactérias ambientais, contagiosas e outras. Estas perfizeram 57,3%, 26,3% e 11,2%, respectivamente, dos animais amostrados. Testes de suscetibilidade antimicrobiana contra 12 diferentes antimicrobianos foram realizados em 159 isolados. No total, 30% dos isolados testados mostraram resistência a pelo menos três grupos diferentes de antimicrobianos e foram classificados como multirresistentes. Foram observadas as freqüências mais elevadas de resistência contra a ampicilina para os estafilococos coagulase-negativo, seguida de eritromicina para estafilococos coagulase-positivo e tetraciclina para estreptococos. A análise de regressão logística mostrou uma relação significativa entre a idade das vacas e a presença de estafilococos coagulase-positivo multirresistentes e distribuição de classes diferentes de bactérias nos diferentes estratos etários, o que sugere uma concorrência dinâmica ao longo do tempo (p < 0,05). Animais com três a quatro anos tiveram 13,7 vezes mais chances (IC95% 1,4 - 130,2, p = 0,02) de ter estafilococos coagulase-positivo multirresistentes em comparação com aqueles com dois ou três anos. O tempo de exposição a agentes infecciosos e consequentes terapias sugere uma maior chance de colonização do úbere por patógenos resistentes devido à pressão de seleção repetida durante a vida.
https://doi.org/10.1590/S0100-736X2014000700001
3410 downloads
12.
Niemann-Pick disease type C: a case series of Brazilian patients
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Lorenzoni, Paulo José
; Cardoso, Elaine
; Crippa, Ana C. S.
; Lourenço, Charles Marques
; Souza, Fernanda Timm Seabra
; Giugliani, Roberto
; Saraiva-Pereira, Maria Luiza
; Raskin, Salmo
; Bruck, Isac
; Kay, Cláudia S. K.
; Scola, Rosana H.
; C.Werneck, Lineu
; Teive, Hélio A. G.
.













The aim of the study was to analyze a series of Brazilian patients with Niemann-Pick disease type C (NP-C). Method Correlations between clinical findings, laboratory data, molecular findings and treatment response are presented. Result The sample consisted of 5 patients aged 8 to 26 years. Vertical supranuclear gaze palsy, cerebellar ataxia, dementia, dystonia and dysarthria were present in all cases. Filipin staining showed the “classical” pattern in two patients and a “variant” pattern in three patients. Molecular analysis found mutations in the NPC1 gene in all alleles. Miglustat treatment was administered to 4 patients. Conclusion Although filipin staining should be used to confirm the diagnosis, bone marrow sea-blue histiocytes often help to diagnosis of NP-C. The p.P1007A mutation seems to be correlated with the “variant” pattern in filipin staining. Miglustat treatment response seems to be correlated with the age at disease onset and disability scale score at diagnosis.
O objetivo desse estudo foi analisar uma série de casos de pacientes brasileiros com doença de Niemann-Pick tipo C (NP-C). Método Correlação entre manifestações clínicas, alterações laboratoriais, estudo molecular e resposta ao tratamento foram realizadas. Resultado A amostra consiste de 5 pacientes com idade entre 8 e 26 anos. Paralisia do olhar vertical supranuclear, ataxia cerebelar, demência, distonia e disartria estavam presentes em todos os casos. Coloração de filipina na cultura de fibroblastos mostrou padrão “clássico” em dois pacientes e padrão “variante” em três casos. O estudo molecular encontrou mutações no gene NPC1 em todos os alelos. O tratamento com miglustate foi realizado em 4 pacientes. Conclusão Embora coloração de filipina seja utilizada para confirmar o diagnóstico, o histiócito azul-marinho no aspirado de medula óssea frequentemente auxilia a confirmar o diagnóstico de NP-C. A mutação p.P1007A está correlacionada com o padrão “ variante” na coloração de filipina. A resposta ao tratamento com miglustate parece estar correlacionada com a idade e escore de desabilidade no momento do diagnóstico.
https://doi.org/10.1590/0004-282X20130249
7066 downloads
13.
Unroofed coronary sinus in a patient with neurofibromatosis type 1
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Bender, Luciano Pereira
; Meyer, Maria Rita F.
; Rosa, Rafael Fabiano M.
; Rosa, Rosana Cardoso M.
; Trevisan, Patrícia
; Zen, Paulo Ricardo G.
.






OBJECTIVE: To report the uncommon association between neurofibromatosis type 1 (NF1) and unroofed coronary sinus. CASE DESCRIPTION: Girl with four years and six months old who was hospitalized for heart surgery. The cardiac problem was discovered at four months of life. On physical examination, the patient presented several café-au-lait spots in the trunk and the limbs and freckling of the axillary and groin regions. Her father had similar skin findings, suggesting the NF1 diagnosis. The cardiac evaluation by echocardiography disclosed an atrial septal defect of unroofed coronary sinus type. This cardiac finding was confirmed at surgery. The procedure consisted of the atrial septal defect repair with autologous pericardium. COMMENTS: NF1 is a common autosomal dominant disorder caused by mutations in the NF1 gene. Among the NF1 findings, congenital heart defects are considered unusual. In the literature review, there was no association between NF1 and unroofed coronary sinus, which is a rare cardiac malformation, characterized by a communication between the coronary sinus and the left atrium, resultant from the partial or total absence of the coronary sinus roof. It represents less than 1% of atrial septal defect cases. More reports are important to determine if this association is real or merely casual, since NF1 is a common condition.
OBJETIVO: Subrayar la asociación poco común entre neurofibromatosis de tipo 1 (NF1) y seno coronario sin techo. DESCRIPCIÓN DEL CASO: Niña de cuatro años y seis meses, hospitalizada para realización de cirugía cardíaca. Se descubrió el problema cardíaco con cuatro meses de vida. En el examen físico, la paciente presentaba varias manchas café con leche en el tronco y en los miembros y lentigos axilares e inguinales. El padre poseía alteraciones de piel semejantes, siendo posible el diagnóstico de NF1. La evaluación cardiaca mediante ecocardiograma reveló comunicación interatrial de tipo seno coronario sin techo. Esos hallazgos cardiacos fueron confirmados en la cirugía. El procedimiento constituye en la reparación del defecto del septo atrial con pericardio autólogo. COMENTARIOS: NF1 es una enfermedad autosómica dominante común causada por mutaciones del gene NF1. Entre los hallazgos de NF1, los defectos cardiacos congénitos son considerados poco comunes. En la revisión de la literatura, no hubo asociación entre NF1 y el seno coronario sin techo, que es una malformación cardiaca rara caracterizada por la comunicación entre el seno coronario y el atrio izquierdo, resultante de la ausencia parcial o total del techo del seno coronario, representando menos del 1% de los casos de defecto del septo atrial. Más relatos son importantes para determinar si esa asociación es real o solamente casual, ya que NF1 es una condición común.
OBJETIVO: Relatar a associação incomum entre neurofibromatose do tipo 1 (NF1) e seio coronário sem teto. DESCRIÇÃO DO CASO: Menina de quatro anos e seis meses, hospitalizada para realização de cirurgia cardíaca. O problema cardíaco foi descoberto com quatro meses de vida. No exame físico, a paciente apresentava várias manchas café com leite no tronco e nos membros e efélides axilares e inguinais. O pai possuía alterações de pele semelhantes, sendo possível o diagnóstico de NF1. A avaliação cardíaca por meio do ecocardiograma revelou comunicação interatrial do tipo seio coronário sem teto. Esses achados cardíacos foram confirmados na cirurgia. O procedimento consistiu na reparação do defeito do septo atrial com pericárdio autólogo. COMENTÁRIOS: A NF1 é uma doença autossômica dominante comum causada por mutações no gene NF1. Dentre os achados da NF1, os defeitos cardíacos congênitos são considerados pouco comuns. Na revisão da literatura, não houve associação entre a NF1 e o seio coronário sem teto, o qual é uma malformação cardíaca rara caracterizada pela comunicação entre o seio coronário e o átrio esquerdo, resultante da ausência parcial ou total do teto do seio coronário, representando menos de 1% dos casos de defeito do septo atrial. Mais relatos são importantes para determinar se essa associação é real ou apenas casual, já que a NF1 é uma condição comum.
https://doi.org/10.1590/S0103-05822013000400019
3548 downloads
14.
Associação entre consumo de alimentos embutidos e obesidade em um estudo de base populacional de nipo-brasileiros
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Arquivos Brasileiros de Endocrinologia & Metabologia
- Journal Metrics
OBJECTIVE: The aim of this study was to investigate the association between the consumption of processed meat with overall, abdominal, and overall with abdominal obesity in a Japanese-Brazilian population, which is known to be at cardiometabolic risk. SUBJECTS AND METHODS: A total of 329 men and 443 women aged ≥ 30 years were evaluated in a cross-sectional population-based survey. Diagnosis of overall obesity and abdominal obesity were based on the World Health Organization (WHO) criteria for Asians. Food intake was assessed by a validated food frequency questionaire. RESULTS: In men, processed meat intake was positively associated with overall with abdominal obesity (OR 2.97; 95%CI 1.13-7.78) after adjustment. In women, only the red meat group was associated with overall with abdominal obesity after adjustment (OR 0.47, 95%CI 0.23-0.96). CONCLUSION: Our results showed that high intakes of processed meats were associated with overall with abdominal obesity in male Japanese-Brazilians, but not in females.
OBJETIVO: Investigar a associação entre consumo de alimentos embutidos e obesidade generalizada, abdominal e generalizada com abdominal em nipo-brasileiros de Bauru, SP. SUJEITOS E MÉTODOS: Quatrocentos e quarenta e três mulheres e 329 homens nipo-brasileiros não miscigenados (≥ 30 anos) foram avaliados em estudo transversal de base populacional. Para o diagnóstico de obesidade, foram empregados os critérios da Organização Mundial da Saúde para asiáticos. A ingestão de alimentos foi avaliada por meio de questionário de frequência alimentar validado. A ingestão foi estratificada em terços para análise. RESULTADOS: Nos homens, a ingestão de colesterol e alimentos embutidos mostrou-se positivamente associada à obesidade generalizada com abdominal quando o primeiro terço de ingestão foi comparado ao último, após ajustes (OR 2,97; IC95% 1,13-7,78). Em mulheres, somente o grupo das carnes vermelhas associou-se à obesidade geral com abdominal após ajustes (OR 0,47; IC95% 0,23-0,96). CONCLUSÃO: Ingestão elevada de alimentos embutidos associou-se à obesidade generalizada com adiposidade abdominal em homens nipo-brasileiros, mas não em mulheres.
https://doi.org/10.1590/S0004-27302013000600009
9058 downloads
15.
Perspectives in isolation of microRNA from thyroid fine-needle aspiration: reply to the letter "Nucleic acid recovery from thyroid fine-needle cytology slides"
Facebook Twitter

Facebook Twitter
- Other social networks
- Google+
- StambleUpon
- CiteULike
- Mendeley
- Other networks
- Metrics
Kizys, Marina M. L.
; Cardoso, Mirian G.
; Lindsey, Susan C.
; Melo, Maria Clara C.
; Dias-da-Silva, Magnus R.
.





Arquivos Brasileiros de Endocrinologia & Metabologia
- Journal Metrics
https://doi.org/10.1590/S0004-27302013000600014
1376 downloads
Showing
itens per page
Page
of 3
Next
Statistics of
Send result
Sem resultados
No documents were found for your search
Glossary and search help
You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.
For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:ti:dengue and publication_year:2015 and aff_country:Brasil
See below the complete list of search indexes that can be used:
Index code | Element |
---|---|
ti | article title |
au | author |
kw | article keywords |
subject | subject (title words, abstract and keywords) |
ab | abstract |
ta | journal short title (e.g. Cad. Saúde Pública) |
journal_title | journal full title (e.g. Cadernos de Saúde Pública) |
la | publication language code (e.g. pt - Portuguese, es - Spanish) |
type | document type |
pid | publication identifier |
publication_year | publication year of publication |
sponsor | sponsor |
aff_country | country code of the author's affiliation |
aff_institution | author affiliation institution |
volume | article volume |
issue | article issue |
elocation | elocation |
doi | DOI number |
issn | journal ISSN |
in | SciELO colection code (e.g. scl - Brasil, col - Colômbia) |
use_license | article usage license code |