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Abstract Background Heart rate (HR) has shown prognostic value in patients with heart failure with reduced ejection fraction (HFrEF) and sinus rhythm. However, the method of measurement is debated in the literature. Objectives To compare HR on Holter with 3 resting electrocardiograms (ECG1, ECG2, and ECG3) in patients with HFrEF and sinus rhythm. Methods This was a cross-sectional study with 135 patients with heart failure with ejection fraction ≤ 40% and sinus rhythm. HR was assessed by ECG and Holter. Analyses included intraclass correlation coefficient (ICC), robust regression, root mean squared error, Bland-Altman, and area under the receiver operating characteristic (ROC) curve. A significance level of 0.05 and Bonferroni-Holm adjustment were adopted to minimize type I errors. Results The median [interquartile range] age and ejection fraction were 65 years [16] and 30% [11], respectively. The ICC of the 3 ECGs was 0.922 (95% confidence interval: 0.892; 0.942). The robust regression coefficients for ECG1 and ECG3 were 0.20 (95% confidence interval: 0.12; 0.29) and 0.21 (95% confidence interval: 0.06; 0.36). The robust R2 was 0.711 (95% confidence interval: 0.628; 0.76). In the Bland-Altman agreement analysis, the limits of agreement were −17.0 (95% confidence interval: −19.0; −15.0) and 32.0 (95% confidence interval: 30.0; 34.0). The area under the ROC curve was 0.896 (95% confidence interval: 0.865; 0.923). Conclusion The HR on ECG showed high agreement with the HR on Holter, validating its clinical use in patients with HFrEF and sinus rhythm. However, agreement was suboptimal in one third of patients with HR below 70 bpm on ECG; thus, 24-hour Holter monitoring should be considered in this context. (HR (HFrEF rhythm However literature ECG1, (ECG1 ECG2 crosssectional cross sectional 13 40 ICC, , (ICC) error BlandAltman, BlandAltman Bland Altman, Altman (ROC 005 0 05 0.0 BonferroniHolm Bonferroni Holm errors interquartile range 6 16 [16 30 11, 11 [11] respectively 0922 922 0.92 95% 95 (95 interval 0.892 0892 892 0.942. 0942 0.942 . 942 0.942) 020 20 0.2 0.12 012 12 0.29 029 29 021 21 0.06 006 06 0.36. 036 0.36 36 0.36) R 0711 711 0.71 0.628 0628 628 0.76. 076 0.76 76 0.76) analysis 170 17 −17. −19.0 190 19 −15.0 150 15 320 32 32. 30.0 300 34.0. 340 34.0 34 34.0) 0896 896 0.89 0.865 0865 865 0.923. 0923 0.923 923 0.923) 7 thus 24hour hour 24 context (ECG 1 4 (ICC 00 0. [1 [11 092 92 0.9 9 (9 089 89 094 0.94 94 02 2 0.1 01 03 0.3 071 71 0.7 0.62 062 62 07 −17 −19. −15. 30. 34. 0.8 0.86 086 86 [ 09 ( 08 8 0.6 −1 −19 −15 −

Resumo Fundamento A frequência cardíaca (FC) na insuficiência cardíaca com fração de ejeção reduzida (ICFEr) e ritmo sinusal apresenta valor prognóstico. Entretanto, o método de mensuração é debatido na literatura. Objetivos Comparar em pacientes com ICFEr e ritmo sinusal a FC no Holter com três eletrocardiogramas de repouso: ECG1, ECG2 e ECG3. Metodologia Estudo transversal com 135 pacientes portadores de insuficiência cardíaca com fração de ejeção ≤ 40% e ritmo sinusal. A FC foi avaliada por ECG e Holter. Análises incluíram o coeficiente de correlação intraclasse (CCI), regressão robusta, raiz do erro quadrático médio, Bland-Altman e a área sobre a curva ROC. Adotou-se nível de significância de 0,05 e o ajuste de Bonferroni-Holm para minimizar erros tipo I. Resultados As medianas [intervalo interquartil] de idade e fração de ejeção foram de 65 anos [16] e 30% [11], respectivamente. O CCI dos 3 ECG foi de 0,922 (intervalo de confiança de 95%: 0,892; 0,942). Os coeficientes de regressão robusta para ECG1 e ECG3 foram 0,20 (intervalo de confiança de 95%: 0,12; 0,29) e 0,21 (intervalo de confiança de 95%: 0,06; 0,36). O R2 robusto foi de 0,711 (intervalo de confiança de 95%: 0,628; 0,76). Na análise de concordância de Bland-Altman, os limites de concordância foram de −17,0 (intervalo de confiança de 95%: −19,0; −15,0) e 32,0 (intervalo de confiança de 95%: 30,0; 34,0). A área sob a curva ROC foi de 0,896 (intervalo de confiança de 95%: 0,865; 0,923). Conclusão A FC do ECG mostrou alta concordância com a FC do Holter, validando seu uso clínico em pacientes com ICFEr e ritmo sinusal. Contudo, a concordância foi subótima em um terço dos pacientes com FC inferior a 70 bpm pelo ECG, devendo ser considerada a realização de Holter neste contexto. (FC (ICFEr prognóstico Entretanto literatura repouso 13 40 CCI, , (CCI) médio BlandAltman Bland Altman Adotouse Adotou se 005 0 05 0,0 BonferroniHolm Bonferroni Holm I intervalo interquartil 6 16 [16 30 11, 11 [11] respectivamente 0922 922 0,92 95% 95 0,892 0892 892 0,942. 0942 0,942 . 942 0,942) 020 20 0,2 0,12 012 12 0,29 029 29 021 21 0,06 006 06 0,36. 036 0,36 36 0,36) R 0711 711 0,71 0,628 0628 628 0,76. 076 0,76 76 0,76) BlandAltman, Altman, 170 17 −17, −19,0 190 19 −15,0 150 15 320 32 32, 30,0 300 34,0. 340 34,0 34 34,0) 0896 896 0,89 0,865 0865 865 0,923. 0923 0,923 923 0,923) Contudo 7 contexto 1 4 (CCI 00 0, [1 [11 092 92 0,9 9 089 89 094 0,94 94 02 2 0,1 01 03 0,3 071 71 0,7 0,62 062 62 07 −17 −19, −15, 30, 34, 0,8 0,86 086 86 [ 09 08 8 0,6 −1 −19 −15 −

https://doi.org/10.36660/abc.20230771

Clinical Characteristics of Genuine Acute Autoimmune Hepatitis
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Oliveira, Elze Maria Gomes

; Amaral, Ana Cristina de Castro

; Oliveira, Patricia Marinho Costa

; Lanzoni, Valéria Pereira

; Perez, Renata Mello

; Narciso-Schiavon, Janaína Luz

; Whale, Raul Carlos

; Carvalho-Filho, Roberto José

; Silva, Antonio Eduardo Benedito

; Ferraz, Maria Lucia Cardoso Gomes

GE-Portuguese Journal of Gastroenterology

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jun 2024, Volume 31 N. 3 Pages 21 - 29

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Introduction: Autoimmune hepatitis (AIH) has a spectrum of symptoms ranging from asymptomatic disease to acute severe hepatitis, chronic hepatitis, and decompensated cirrhosis. The acute presentation is not rare and could represent genuine acute AIH (GAAIH) or acute exacerbation of chronic autoimmune hepatitis. We aimed to identify the prevalence, clinical features, and prognostic factors associated with GAAIH and compare these cases with acute exacerbation of chronic AIH. Methods: This cross-sectional observational study evaluated patients with acute AIH presentation, deﬁned as total bilirubin >5 times the upper limit of normality (xULN) and/or alanine aminotransferase >10 xULN, and no prior history of liver disease. Histology ﬁndings of acute disease deﬁned GAAIH. Bivariate analyses were performed to identify factors associated with the GAAIH, when compared with acute exacerbation of chronic AIH. Results: Seventy-two patients with acute presentation of AIH were included and six (8.3%) of them presented GAAIH. Comparative analysis between patients with GAAIH and patients with acute exacerbation of chronic AIH revealed that prothrombin activity (96% [74-100] vs. 61% [10-100]; p = 0.003) and albumin levels (3.9 ± 0.2 g/dL vs. 3.4 ± 0.5 g/dL; p < 0.001) were higher in patients with GAAIH. The International Autoimmune Hepatitis Group score was higher in patients with acute exacerbation of chronic AIH (18.5 [8-23] vs. 16.5 [15-17]; p = 0.010). Compared to 15.2% of acute exacerbation of chronic AIH, complete therapeutic response to treatment was achieved in 67.7% of cases with GAAIH (p = 0.018). Conclusions: GAAIH was rare (8.3%), and patients with this presentation exhibited more preserved liver function tests, suggesting that most cases presenting with loss of function are acute exacerbation of chronic AIH. Additionally, patients with GAAIH had a better complete therapeutic response, suggesting a more preserved liver function at presentation, and early diagnosis has a positive therapeutic implication.

Resumo Introdução: A hepatite autoimune (HAI) apresenta um espectro de sintomas que varia de doença assintomática a hepatite aguda grave, hepatite crónica e cirrose descompensada. A apresentação aguda não é rara e pode representar hepatite autoimune aguda genuína (HAIAG) ou exacerbação aguda de hepatite autoimune crónica (EAHAIC). O nosso objetivo foi identiﬁcar a prevalência, caraterísticas clínicas e fatores prognósticos associados à HAIAG, e comparar esses casos com EAHAIC. Métodos: Estudo observacional, transversal, incluindo doentes com apresentação aguda de HAI, deﬁnida como bilirrubina total > 5 vezes o limite superior da normalidade (xLSN) e/ou ALT > 10 xLSN, e sem história prévia de doença hepática. HAIAG foi deﬁnida pela presença de achados histológicos de doença aguda. Análises bivariadas foram realizadas para identiﬁcar fatores associados à HAIAG, quando comparado com o EAHAIC. Resultados: Foram incluídos setenta e dois doentes com apresentação agu-da de HAI, dos quais seis (8.3%) com HAIAG. A análise comparativa entre doentes com HAIAG e doentes com EAHAIC mostrou que a atividade de protrombina (96%(74-100) versus 61% (10-100; p=0.003) e os níveis de albumina (3,9 ± 0,2 g/dL vs. 3,4 ± 0,5 g/dL; p < 0,001) foram signiﬁcativamente mais elevados em pacientes com HAIAG. O score do Grupo Internacional de Hepatite Autoimune foi mais elevado em doentes com EAHAIC (18.5 (8-23) versus 16.5 (15-17); p=0.010). A resposta terapêutica completa ao tratamento foi alcançada em 66.7% dos casos de HAIAG (vs. 15,2% na EAHAIC, p=0,018). Conclusões: A HAIAG é rara (8.3%), e os doentes com esta apresentação mostraram testes de função hepática mais preservados, sugerindo que a maioria dos casos com perda de função são EAHAIC. Além disso, os doentes com HAIAG tiveram maior taxa de resposta terapêutica completa, sugerindo que uma função hepática mais preservada na apresentação e o diagnóstico precoce tem uma implicação terapêutica positiva.

https://doi.org/10.1159/000531018

[SciELO Preprints] - Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy – 2024
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Fernandes, Fabio Simões, Marcus V. Correia, Edileide de Barros Marcondes-Braga, Fabiana G. Coelho-Filho, Otavio Rizzi Mesquita, Cláudio Tinoco Mathias-Junior, Wilson Rochitte, Carlos Eduardo Ramires, Felix José Alvarez Alves, Silvia Marinho Martins Montera, Marcelo Westerlund Lopes, Renato Delascio Oliveira-Junior, Mucio Tavares Scolari, Fernando L. Avila, Walkiria Samuel Canesin, Manoel Fernandes Bacal, Fernando Bocchi, Edimar Alcides Moura, Lídia Ana Zytynski Saad, Eduardo Benchimol Scanavacca, Mauricio I. Valdigem, Bruno Pereira Cano , Manuel Nicolas Abizaid , Alexandre Ribeiro, Henrique Barbosa Lemos-Neto, Pedro Alves Ribeiro, Gustavo Calado de Aguiar Jatene, Fabio Biscegli Dias, Ricardo Ribeiro Beck-da-Silva, Luis Rohde, Luis Eduardo P. Bittencourt, Marcelo Imbroinise Pereira, Alexandre Krieger, José Eduardo Villacorta, Humberto Martins, Wolney de Andrade Figueiredo-Neto, José Albuquerque de Cardoso , Juliano Novaes Pastore, Carlos Alberto Jatene, Ieda Biscegli Tanaka, Ana Cristina Sayuri Hotta, Viviane Tiemi Romano, Minna Moreira Dias Albuquerque, Denilson Campos de Mourilhe-Rocha, Ricardo Hajjar, Ludhmila Abrahão Brito, Fabio Sandoli de Caramelli , Bruno Calderaro, Daniela Farsky, Pedro Silvio Colafranceschi , Alexandre Siciliano Pinto, Ibraim Masciarelli Vieira , Marcelo Luiz Campos Danzmann, Luiz Claudio Barberato , Silvio Henrique Mady, Charles Martinelli-Filho, Martino Torbey , Ana Flavia Malheiros Schwartzmann, Pedro Vellosa Macedo, Ariane Vieira Scarlatelli Ferreira , Silvia Moreira Ayub Schmidt, Andre Melo , Marcelo Dantas Tavares de Lima-Filho, Moysés Oliveira Sposito, Andrei C. Brito, Flavio de Souza Biolo, Andreia Madrini-Junior, Vagner Rizk, Stéphanie Itala Mesquita, Evandro Tinoco

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Publication date: 2024-04-08

Abstract: Pt Es En

A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE.   Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).

La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).

Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.

https://doi.org/10.1590/SciELOPreprints.8394

O impacto da assistência técnica e extensão rural para os agricultores familiares pobres: o caso do Programa Dom Hélder Câmara II pobres
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Delgrossi, Mauro Eduardo

; Vieira, Ludgero Cardoso Galli

; Avila, Mário Lúcio de

; Valencia Perafán, Mireya

; Miranda Filho, Reinaldo José de

Revista de Economia e Sociologia Rural

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2024, Volume 62 N. 2 elocation e271282

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract This study evaluates the impact of technical assistance and rural extension provided by the Dom Hélder Câmara Project (PDHC II) in the Brazilian semiarid region, which aimed to reduce the poverty levels and inequalities in the region, qualifying family farmers to develop sustainable production and encouraging the replication of good agricultural practices. Using the propensity score matching method, 16 different indicators of the assisted families and the control group were analyzed, involving monetary and nonmonetary incomes. The results indicate that the program was successful in benefiting poor or extremely poor families in this region, providing technical assistance and rural extension and, for a fraction of them, access to the Rural Funding Program. In addition, PDHC II achieved its objectives of providing an increase in agricultural production and in the income of the beneficiaries, with an even more prominent impact among those who received remittances from funding program. It can be concluded that technical assistance and rural extension were effective, benefiting poor family farmers in the Brazilian semiarid region and having a larger impact when associated with productive funding resources. practices method 1 analyzed incomes them Program addition beneficiaries effective resources

Resumo Este estudo avalia o impacto da assistência técnica e extensão rural prestadas pelo Projeto Dom Hélder Câmara (PDHC II) no semiárido brasileiro, que teve como objetivos a redução dos níveis de pobreza e das desigualdades na região, qualificando os agricultores familiares para desenvolverem uma produção sustentável e estimulando a replicação de boas práticas agropecuárias. Utilizando o método “propensity score matching” foram analisados 16 diferentes indicadores das famílias atendidas e do grupo de controle, envolvendo rendas monetárias e não monetárias. Os resultados apontam que o programa logrou êxito em beneficiar famílias pobres ou extremamente pobres dessa região, levando assistência técnica e extensão rural e, para uma fração deles, o acesso ao Programa Fomento Rural. Além disso, o PDHC II atingiu seus objetivos de propiciar um incremento na produção agrícola e nos rendimentos dos beneficiários, com um impacto ainda mais proeminente entre aqueles que receberam os recursos de fomento produtivo. Pode-se concluir que a assistência técnica e extensão rural foram eficazes, beneficiando agricultores familiares pobres do semiárido brasileiro, tendo maior impacto quando associada aos recursos de fomento produtivo. brasileiro região agropecuárias propensity matching 1 controle deles Rural disso beneficiários produtivo Podese Pode se eficazes

https://doi.org/10.1590/1806-9479.2022.271282pt

Use of surgical videos available on social media among retina surgeons: results of a vitreoretinal specialist survey surgeons
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Lucatto, Luiz Filipe Adami

; Barbosa, Gabriel Castilho Sandoval

; Prazeres, Juliana Moura Bastos

; Cardoso, Emmerson Badaró

; Guerra, Ricardo Luz Leitão

; Lima, Luiz Henrique Soares Gonçalves de

; Rodrigues, Eduardo Büchele

Arquivos Brasileiros de Oftalmologia

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2024, Volume 87 N. 4 elocation e2022-0166

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Purpose: This study aimed to assess and interpret how vitreoretinal surgeons use surgical videos available on social media as complementary learning tools to improve, review, or update their abilities, considering their different levels of expertise. Methods: In this cross-sectional survey, an online survey was sent to vitreoretinal specialists and fellows. Results: This survey included 258 participants, of whom 53.88% had been in practice for >10 years (senior surgeons), 29.07% between 4 and 10 years (young surgeons), and 17.05% for <3 years (surgeons in training). Retinal surgical videos available on social media were used by 98.84% of the participants (95% confidence interval, 97.52%-100%). YouTube (91%) was the most common source of videos, and surgeons in training watched more videos on YouTube than senior surgeons. Regarding the preferred method when preparing for a procedure, 49.80% of the participants watched surgical videos available on social media, 26.27% preferred to “consult colleagues”, and 18.82% preferred to seek information in scientific articles. Participants valued the most the “image quality” (88%) and presence of “surgical tips and tricks” (85%). Conclusion: Surgical videos can provide benefits in acquiring strategic skills, such as decision-making, surgical planning, and situational awareness. Retina surgeons used them as teaching aids regardless of their level of expertise, despite being relatively more valuable to surgeons in training or young surgeons. Purpose improve review abilities expertise Methods crosssectional cross sectional fellows Results 25 5388 53 88 53.88 >1 surgeons, , surgeons) 2907 29 07 29.07 1 1705 17 05 17.05 3 < training. . training) 9884 98 84 98.84 95% 95 (95 interval 97.52%100%. 9752100 97.52% 100% 97 52 100 97.52%-100%) 91% 91 (91% procedure 4980 49 80 49.80 2627 26 27 26.27 consult colleagues, colleagues colleagues” 1882 18 82 18.82 articles image quality 88% (88% tricks 85%. 85 85% (85%) Conclusion skills decisionmaking, decisionmaking decision making, making decision-making planning awareness 2 538 5 8 53.8 > 290 0 29.0 170 17.0 988 9 98.8 (9 97.52%100% 975210 9752 97.52 97.52%-100% (91 498 49.8 262 26.2 188 18.8 (88 (85% 53. 29. 17. 98. ( 97.52%100 97521 975 97.5 97.52%-100 49. 26. 18. (8 (85 97.52%10 97. 97.52%-10 97.52%1 97.52%-1 97.52%-

RESUMO Objetivo: Avaliar e interpretar como os cirurgiões vitreorretinianos utilizam os vídeos cirúrgicos disponíveis nas mídias sociais como ferramentas complementares de aprendizagem para melhorar, revisar ou atualizar suas habilidades, considerando seus diferentes níveis de especialização. Métodos: Nesta pesquisa transversal, um survey online foi enviado à especialistas e aprendizes na área vítreo-retiniana. Resultados: Esta pesquisa incluiu 258 participantes, dos quais 53,88% atuavam há mais de 10 anos (cirurgiões seniores), 29,07% entre 4 e 10 anos (cirurgiões jovens) e 17,05% há menos de 3 anos (cirurgiões em treinamento). Vídeos cirúrgicos de retina nas mídias sociais foram usados por 98,84% dos participantes (intervalo de confiança de 95%, 97,52%-100%). A fonte mais comum de acesso aos vídeos foi o YouTube (91%), e o grupo de cirurgiões com menos de 3 anos de experiência assistiu mais vídeos no YouTube em comparação aos cirurgiões seniores. Assistir a vídeos cirúrgicos nas redes sociais foi o método preferido na preparação para um procedimento para 49,80% dos participantes versus 26,27% que preferiram “consultar colegas” e 18,82% que preferiram buscar informações em artigos científicos. A “qualidade de imagem” (88%) e a presença de “dicas e truques cirúrgicos” (85%) foram as características dos vídeos mais valorizadas pelos participantes. Conclusão: O uso de vídeos cirúrgicos pode trazer benefícios na aquisição de habilidades estratégicas, como tomada de decisão, planejamento cirúrgico e consciência situacional. Sua aplicação como auxiliar de ensino foi utilizada por cirurgiões de retina independentemente de seu nível de especialização, apesar de ser relativamente mais valioso para cirurgiões em formação ou com menos de 10 anos de experiência. Objetivo melhorar especialização Métodos transversal vítreoretiniana. vítreoretiniana vítreo retiniana. retiniana vítreo-retiniana Resultados 25 5388 53 88 53,88 1 seniores, seniores , seniores) 2907 29 07 29,07 jovens 1705 17 05 17,05 treinamento. treinamento . treinamento) 9884 98 84 98,84 intervalo 95 95% 97,52%100%. 9752100 97,52% 100% 97 52 100 97,52%-100%) 91%, 91 91% (91%) 4980 49 80 49,80 2627 26 27 26,27 consultar colegas 1882 18 82 18,82 científicos qualidade imagem 88% (88% dicas 85% 85 (85% Conclusão estratégicas decisão situacional 2 538 5 8 53,8 290 0 29,0 170 17,0 988 9 98,8 97,52%100% 975210 9752 97,52 97,52%-100% (91% 498 49,8 262 26,2 188 18,8 (88 (85 53, 29, 17, 98, 97,52%100 97521 975 97,5 97,52%-100 (91 49, 26, 18, (8 97,52%10 97, 97,52%-10 (9 ( 97,52%1 97,52%-1 97,52%-

https://doi.org/10.5935/0004-2749.2022-0166

Disease progression in Sanfilippo type B: Case series of Brazilian patients B
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Montenegro, Yorran Hardman Araújo

; Kubaski, Francyne

; Trapp, Franciele Barbosa

; Riegel-Giugliani, Mariluce

; Souza, Carolina Fischinger Moura de

; Ribeiro, Erlane Marques

; Lourenço, Charles Marques

; Cardoso-dos-Santos, Augusto César

; Ribeiro, Márcia Gonçalves

; Kim, Chong Ae

; Castro, Matheus Augusto Araújo

; Embiruçu, Emília Katiane

; Steiner, Carlos Eduardo

; Vairo, Filippo Pinto e

; Baldo, Guilherme

; Giugliani, Roberto

; Poswar, Fabiano de Oliveira

Genetics and Molecular Biology

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2024, Volume 47 N. 1 elocation e20230285

Abstract: En | Text: En | PDF: En

Abstract Mucopolysaccharidosis type IIIB (MPS IIIB) is caused by deficiency of alpha-N-acetylglucosaminidase, leading to storage of heparan sulphate. The disease is characterized by intellectual disability and hyperactivity, among other neurological and somatic features. Here we studied retrospective data from a total of 19 MPS IIIB patients from Brazil, aiming to evaluate disease progression. Mean age at diagnosis was 7.2 years. Speech delay was one of the first symptoms to be identified, around 2-3 years of age. Behavioral alterations include hyperactivity and aggressiveness, starting around age four. By the end of the first decade, patients lost acquired abilities such as speech and ability to walk. Furthermore, as disease progresses, respiratory, cardiovascular and joint abnormalities were found in more than 50% of the patients, along with organomegaly. Most common cause of death was respiratory problems. The disease progression was characterized in multiple systems, and hopefully these data will help the design of appropriate clinical trials and clinical management guidelines. alphaNacetylglucosaminidase, alphaNacetylglucosaminidase alpha N acetylglucosaminidase, acetylglucosaminidase alpha-N-acetylglucosaminidase sulphate features 1 Brazil 72 7 2 7. identified 23 3 2- aggressiveness four decade walk Furthermore progresses 50 organomegaly problems systems guidelines 5

https://doi.org/10.1590/1678-4685-gmb-2023-0285

Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.

; Valim, Michel P.

; Zaher, Hussam

; Rafael, José A.

; Forzza, Rafaela C.

; Percequillo, Alexandre R.

; Serejo, Cristiana S.

; Garraffoni, André R.S.

; Santos, Adalberto J.

; Slipinski, Adam

; Linzmeier, Adelita M.

; Calor, Adolfo R.

; Garda, Adrian A.

; Kury, Adriano B.

; Fernandes, Agatha C.S.

; Agudo-Padrón, Aisur I.

; Akama, Alberto

; Silva Neto, Alberto M. da

; Burbano, Alejandro L.

; Menezes, Aleksandra

; Pereira-Colavite, Alessandre

; Anichtchenko, Alexander

; Lees, Alexander C.

; Bezerra, Alexandra M.R.

; Domahovski, Alexandre C.

; Pimenta, Alexandre D.

; Aleixo, Alexandre L.P.

; Marceniuk, Alexandre P.

; Paula, Alexandre S. de

; Somavilla, Alexandre

; Specht, Alexandre

; Camargo, Alexssandro

; Newton, Alfred F.

; Silva, Aline A.S. da

; Santos, Aline B. dos

; Tassi, Aline D.

; Aragão, Allan C.

; Santos, Allan P.M.

; Migotto, Alvaro E.

; Mendes, Amanda C.

; Cunha, Amanda

; Chagas Júnior, Amazonas

; Sousa, Ana A.T. de

; Pavan, Ana C.

; Almeida, Ana C.S.

; Peronti, Ana L.B.G.

; Henriques-Oliveira, Ana L.

; Prudente, Ana L.

; Tourinho, Ana L.

; Pes, Ana M.O.

; Carmignotto, Ana P.

; Wengrat, Ana P.G. da Silva

; Dornellas, Ana P.S.

; Molin, Anamaria Dal

; Puker, Anderson

; Morandini, André C.

; Ferreira, André da S.

; Martins, André L.

; Esteves, André M.

; Fernandes, André S.

; Roza, André S.

; Köhler, Andreas

; Paladini, Andressa

; Andrade, Andrey J. de

; Pinto, Ângelo P.

; Salles, Anna C. de A.

; Gondim, Anne I.

; Amaral, Antonia C.Z.

; Rondón, Antonio A.A.

; Brescovit, Antonio

; Lofego, Antônio C.

; Marques, Antonio C.

; Macedo, Antonio

; Andriolo, Artur

; Henriques, Augusto L.

; Ferreira Júnior, Augusto L.

; Lima, Aurino F. de

; Barros, Ávyla R. de A.

; Brito, Ayrton do R.

; Romera, Bárbara L.V.

; Vasconcelos, Beatriz M.C. de

; Frable, Benjamin W.

; Santos, Bernardo F.

; Ferraz, Bernardo R.

; Rosa, Brunno B.

; Sampaio, Brunno H.L.

; Bellini, Bruno C.

; Clarkson, Bruno

; Oliveira, Bruno G. de

; Corrêa, Caio C.D.

; Martins, Caleb C.

; Castro-Guedes, Camila F. de

; Souto, Camilla

; Bicho, Carla de L.

; Cunha, Carlo M.

; Barboza, Carlos A. de M.

; Lucena, Carlos A.S. de

; Barreto, Carlos

; Santana, Carlos D.C.M. de

; Agne, Carlos E.Q.

; Mielke, Carlos G.C.

; Caetano, Carlos H.S.

; Flechtmann, Carlos H.W.

; Lamas, Carlos J.E.

; Rocha, Carlos

; Mascarenhas, Carolina S.

; Margaría, Cecilia B.

; Waichert, Cecilia

; Digiani, Celina

; Haddad, Célio F.B.

; Azevedo, Celso O.

; Benetti, Cesar J.

; Santos, Charles M.D. dos

; Bartlett, Charles R.

; Bonvicino, Cibele

; Ribeiro-Costa, Cibele S.

; Santos, Cinthya S.G.

; Justino, Cíntia E.L.

; Canedo, Clarissa

; Bonecker, Claudia C.

; Santos, Cláudia P.

; Carvalho, Claudio J.B. de

; Gonçalves, Clayton C.

; Galvão, Cleber

; Costa, Cleide

; Oliveira, Cléo D.C. de

; Schwertner, Cristiano F.

; Andrade, Cristiano L.

; Pereira, Cristiano M.

; Sampaio, Cristiano

; Dias, Cristina de O.

; Lucena, Daercio A. de A.

; Manfio, Daiara

; Amorim, Dalton de S.

; Queiroz, Dalva L. de

; Colpani, Daniara

; Abbate, Daniel

; Aquino, Daniel A.

; Burckhardt, Daniel

; Cavallari, Daniel C.

; Prado, Daniel de C. Schelesky

; Praciano, Daniel L.

; Basílio, Daniel S.

; Bená, Daniela de C.

; Toledo, Daniela G.P. de

; Takiya, Daniela M.

; Fernandes, Daniell R.R.

; Ament, Danilo C.

; Cordeiro, Danilo P.

; Silva, Darliane E.

; Pollock, Darren A.

; Muniz, David B.

; Gibson, David I.

; Nogueira, David S.

; Marques, Dayse W.A.

; Lucatelli, Débora

; Garcia, Deivys M.A.

; Baêta, Délio

; Ferreira, Denise N.M.

; Rueda-Ramírez, Diana

; Fachin, Diego A.

; Souza, Diego de S.

; Rodrigues, Diego F.

; Pádua, Diego G. de

; Barbosa, Diego N.

; Dolibaina, Diego R.

; Amaral, Diogo C.

; Chandler, Donald S.

; Maccagnan, Douglas H.B.

; Caron, Edilson

; Carvalho, Edrielly

; Adriano, Edson A.

; Abreu Júnior, Edson F. de

; Pereira, Edson H.L.

; Viegas, Eduarda F.G.

; Carneiro, Eduardo

; Colley, Eduardo

; Eizirik, Eduardo

; Santos, Eduardo F. dos

; Shimbori, Eduardo M.

; Suárez-Morales, Eduardo

; Arruda, Eliane P. de

; Chiquito, Elisandra A.

; Lima, Élison F.B.

; Castro, Elizeu B. de

; Orlandin, Elton

; Nascimento, Elynton A. do

; Razzolini, Emanuel

; Gama, Emanuel R.R.

; Araujo, Enilma M. de

; Nishiyama, Eric Y.

; Spiessberger, Erich L.

; Santos, Érika C.L. dos

; Contreras, Eugenia F.

; Galati, Eunice A.B.

; Oliveira Junior, Evaldo C. de

; Gallardo, Fabiana

; Hernandes, Fabio A.

; Lansac-Tôha, Fábio A.

; Pitombo, Fabio B.

; Dario, Fabio Di

; Santos, Fábio L. dos

; Mauro, Fabio

; Nascimento, Fabio O. do

; Olmos, Fabio

; Amaral, Fabio R.

; Schunck, Fabio

; Godoi, Fábio S. P. de

; Machado, Fabrizio M.

; Barbo, Fausto E.

; Agrain, Federico A.

; Ribeiro, Felipe B.

; Moreira, Felipe F.F.

; Barbosa, Felipe F.

; Silva, Fenanda S.

; Cavalcanti, Fernanda F.

; Straube, Fernando C.

; Carbayo, Fernando

; Carvalho Filho, Fernando

; Zanella, Fernando C.V.

; Jacinavicius, Fernando de C.

; Farache, Fernando H.A.

; Leivas, Fernando

; Dias, Fernando M.S.

; Mantellato, Fernando

; Vaz-de-Mello, Fernando Z.

; Gudin, Filipe M.

; Albuquerque, Flávio

; Molina, Flavio B.

; Passos, Flávio D.

; Shockley, Floyd W.

; Pinheiro, Francielly F.

; Mello, Francisco de A.G. de

; Nascimento, Francisco E. de L.

; Franco, Francisco L.

; Oliveira, Francisco L. de

; Melo, Francisco T. de V.

; Quijano, Freddy R.B.

; Salles, Frederico F.

; Biffi, Gabriel

; Queiroz, Gabriel C.

; Bizarro, Gabriel L.

; Hrycyna, Gabriela

; Leviski, Gabriela

; Powell, Gareth S.

; Santos, Geane B. dos

; Morse, Geoffrey E.

; Brown, George

; Mattox, George M.T.

; Zimbrão, Geraldo

; Carvalho, Gervásio S.

; Miranda, Gil F.G.

; Moraes, Gilberto J. de

; Lourido, Gilcélia M.

; Neves, Gilmar P.

; Moreira, Gilson R.P.

; Montingelli, Giovanna G.

; Maurício, Giovanni N.

; Marconato, Gláucia

; Lopez, Guilherme E.L.

; Silva, Guilherme L. da

; Muricy, Guilherme

; Brito, Guilherme R.R.

; Garbino, Guilherme S.T.

; Flores, Gustavo E.

; Graciolli, Gustavo

; Libardi, Gustavo S.

; Proctor, Heather C.

; Gil-Santana, Helcio R.

; Varella, Henrique R.

; Escalona, Hermes E.

; Schmitz, Hermes J.

; Rodrigues, Higor D.D.

; Galvão Filho, Hilton de C.

; Quintino, Hingrid Y.S.

; Pinto, Hudson A.

; Rainho, Hugo L.

; Miyahira, Igor C.

; Gonçalves, Igor de S.

; Martins, Inês X.

; Cardoso, Irene A.

; Oliveira, Ismael B. de

; Franz, Ismael

; Fernandes, Itanna O.

; Golfetti, Ivan F.

; S. Campos-Filho, Ivanklin

; Oliveira, Ivo de S.

; Delabie, Jacques H.C.

; Oliveira, Jader de

; Prando, Jadila S.

; Patton, James L.

; Bitencourt, Jamille de A.

; Silva, Janaina M.

; Santos, Jandir C.

; Arruda, Janine O.

; Valderrama, Jefferson S.

; Dalapicolla, Jeronymo

; Oliveira, Jéssica P.

; Hájek, Jiri

; Morselli, João P.

; Narita, João P.

; Martin, João P.I.

; Grazia, Jocélia

; McHugh, Joe

; Cherem, Jorge J.

; Farias Júnior, José A.S.

; Fernandes, Jose A.M.

; Pacheco, José F.

; Birindelli, José L.O.

; Rezende, José M.

; Avendaño, Jose M.

; Duarte, José M. Barbanti

; Ribeiro, José R. Inácio

; Mermudes, José R.M.

; Pujol-Luz, José R.

; Santos, Josenilson R. dos

; Câmara, Josenir T.

; Teixeira, Joyce A.

; Prado, Joyce R. do

; Botero, Juan P.

; Almeida, Julia C.

; Kohler, Julia

; Gonçalves, Julia P.

; Beneti, Julia S.

; Donahue, Julian P.

; Alvim, Juliana

; Almeida, Juliana C.

; Segadilha, Juliana L.

; Wingert, Juliana M.

; Barbosa, Julianna F.

; Ferrer, Juliano

; Santos, Juliano F. dos

; Kuabara, Kamila M.D.

; Nascimento, Karine B.

; Schoeninger, Karine

; Campião, Karla M.

; Soares, Karla

; Zilch, Kássia

; Barão, Kim R.

; Teixeira, Larissa

; Sousa, Laura D. do N.M. de

; Dumas, Leandro L.

; Vieira, Leandro M.

; Azevedo, Leonardo H.G.

; Carvalho, Leonardo S.

; Souza, Leonardo S. de

; Rocha, Leonardo S.G.

; Bernardi, Leopoldo F.O.

; Vieira, Letícia M.

; Johann, Liana

; Salvatierra, Lidianne

; Oliveira, Livia de M.

; Loureiro, Lourdes M.A. El-moor

; Barreto, Luana B.

; Barros, Luana M.

; Lecci, Lucas

; Camargos, Lucas M. de

; Lima, Lucas R.C.

; Almeida, Lucia M.

; Martins, Luciana R.

; Marinoni, Luciane

; Moura, Luciano de A.

; Lima, Luciano

; Naka, Luciano N.

; Miranda, Lucília S.

; Salik, Lucy M.

; Bezerra, Luis E.A.

; Silveira, Luis F.

; Campos, Luiz A.

; Castro, Luiz A.S. de

; Pinho, Luiz C.

; Silveira, Luiz F.L.

; Iniesta, Luiz F.M.

; Tencatt, Luiz F.C.

; Simone, Luiz R.L.

; Malabarba, Luiz R.

; Cruz, Luiza S. da

; Sekerka, Lukas

; Barros, Lurdiana D.

; Santos, Luziany Q.

; Skoracki, Maciej

; Correia, Maira A.

; Uchoa, Manoel A.

; Andrade, Manuella F.G.

; Hermes, Marcel G.

; Miranda, Marcel S.

; Araújo, Marcel S. de

; Monné, Marcela L.

; Labruna, Marcelo B.

; Santis, Marcelo D. de

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; Knoff, Marcelo

; Nogueira, Marcelo

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; Melo, Marcelo R.S. de

; Carvalho, Marcelo R. de

; Tavares, Marcelo T.

; Kitahara, Marcelo V.

; Justo, Marcia C.N.

; Botelho, Marcia J.C.

; Couri, Márcia S.

; Borges-Martins, Márcio

; Felix, Márcio

; Oliveira, Marcio L. de

; Bologna, Marco A.

; Gottschalk, Marco S.

; Tavares, Marcos D.S.

; Lhano, Marcos G.

; Bevilaqua, Marcus

; Santos, Marcus T.T.

; Domingues, Marcus V.

; Sallum, Maria A.M.

; Digiani, María C.

; Santarém, Maria C.A.

; Nascimento, Maria C. do

; Becerril, María de los A.M.

; Santos, Maria E.A. dos

; Passos, Maria I. da S. dos

; Felippe-Bauer, Maria L.

; Cherman, Mariana A.

; Terossi, Mariana

; Bartz, Marie L.C.

; Barbosa, Marina F. de C.

; Loeb, Marina V.

; Cohn-Haft, Mario

; Cupello, Mario

; Martins, Marlúcia B.

; Christofersen, Martin L.

; Bento, Matheus

; Rocha, Matheus dos S.

; Martins, Maurício L.

; Segura, Melissa O.

; Cardenas, Melissa Q.

; Duarte, Mércia E.

; Ivie, Michael A.

; Mincarone, Michael M.

; Borges, Michela

; Monné, Miguel A.

; Casagrande, Mirna M.

; Fernandez, Monica A.

; Piovesan, Mônica

; Menezes, Naércio A.

; Benaim, Natalia P.

; Reategui, Natália S.

; Pedro, Natan C.

; Pecly, Nathalia H.

; Ferreira Júnior, Nelson

; Silva Júnior, Nelson J. da

; Perioto, Nelson W.

; Hamada, Neusa

; Degallier, Nicolas

; Chao, Ning L.

; Ferla, Noeli J.

; Mielke, Olaf H.H.

; Evangelista, Olivia

; Shibatta, Oscar A.

; Oliveira, Otto M.P.

; Albornoz, Pablo C.L.

; Dellapé, Pablo M.

; Gonçalves, Pablo R.

; Shimabukuro, Paloma H.F.

; Grossi, Paschoal

; Rodrigues, Patrícia E. da S.

; Lima, Patricia O.V.

; Velazco, Paul

; Santos, Paula B. dos

; Araújo, Paula B.

; Silva, Paula K.R.

; Riccardi, Paula R.

; Garcia, Paulo C. de A.

; Passos, Paulo G.H.

; Corgosinho, Paulo H.C.

; Lucinda, Paulo

; Costa, Paulo M.S.

; Alves, Paulo P.

; Roth, Paulo R. de O.

; Coelho, Paulo R.S.

; Duarte, Paulo R.M.

; Carvalho, Pedro F. de

; Gnaspini, Pedro

; Souza-Dias, Pedro G.B.

; Linardi, Pedro M.

; Bartholomay, Pedro R.

; Demite, Peterson R.

; Bulirsch, Petr

; Boll, Piter K.

; Pereira, Rachel M.M.

; Silva, Rafael A.P.F.

; Moura, Rafael B. de

; Boldrini, Rafael

; Silva, Rafaela A. da

; Falaschi, Rafaela L.

; Cordeiro, Ralf T.S.

; Mello, Ramon J.C.L.

; Singer, Randal A.

; Querino, Ranyse B.

; Heleodoro, Raphael A.

; Castilho, Raphael de C.

; Constantino, Reginaldo

; Guedes, Reinaldo C.

; Carrenho, Renan

; Gomes, Renata S.

; Gregorin, Renato

; Machado, Renato J.P.

; Bérnils, Renato S.

; Capellari, Renato S.

; Silva, Ricardo B.

; Kawada, Ricardo

; Dias, Ricardo M.

; Siewert, Ricardo

; Brugnera, Ricaro

; Leschen, Richard A.B.

; Constantin, Robert

; Robbins, Robert

; Pinto, Roberta R.

; Reis, Roberto E. dos

; Ramos, Robson T. da C.

; Cavichioli, Rodney R.

; Barros, Rodolfo C. de

; Caires, Rodrigo A.

; Salvador, Rodrigo B.

; Marques, Rodrigo C.

; Araújo, Rodrigo C.

; Araujo, Rodrigo de O.

; Dios, Rodrigo de V.P.

; Johnsson, Rodrigo

; Feitosa, Rodrigo M.

; Hutchings, Roger W.

; Lara, Rogéria I.R.

; Rossi, Rogério V.

; Gerstmeier, Roland

; Ochoa, Ronald

; Hutchings, Rosa S.G.

; Ale-Rocha, Rosaly

; Rocha, Rosana M. da

; Tidon, Rosana

; Brito, Rosangela

; Pellens, Roseli

; Santos, Sabrina R. dos

; Santos, Sandra D. dos

; Paiva, Sandra V.

; Santos, Sandro

; Oliveira, Sarah S. de

; Costa, Sávio C.

; Gardner, Scott L.

; Leal, Sebastián A. Muñoz

; Aloquio, Sergio

; Bonecker, Sergio L.C.

; Bueno, Sergio L. de S.

; Almeida, Sérgio M. de

; Stampar, Sérgio N.

; Andena, Sérgio R.

; Posso, Sergio R.

; Lima, Sheila P.

; Gadelha, Sian de S.

; Thiengo, Silvana C.

; Cohen, Simone C.

; Brandão, Simone N.

; Rosa, Simone P.

; Ribeiro, Síria L.B.

; Letana, Sócrates D.

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; Andrade, Sonia C.S.

; Dávila, Stephane

; Vaz, Stéphanie

; Peck, Stewart B.

; Christo, Susete W.

; Cunha, Suzan B.Z.

; Gomes, Suzete R.

; Duarte, Tácio

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; Sepulveda, Tatiana A.

; Maria, Tatiana F.

; Ruschel, Tatiana P.

; Rodrigues, Thaiana

; Marinho, Thais A.

; Almeida, Thaís M. de

; Miranda, Thaís P.

; Freitas, Thales R.O.

; Pereira, Thalles P.L.

; Zacca, Thamara

; Pacheco, Thaynara L.

; Martins, Thiago F.

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; Carvalho, Thiago R. de

; Polizei, Thiago T.S.

; McElrath, Thomas C.

; Henry, Thomas

; Pikart, Tiago G.

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; Carvalho, Tiago P.

; Lotufo, Tito M. da C.

; Caramaschi, Ulisses

; Pinheiro, Ulisses dos S.

; Pardiñas, Ulyses F.J.

; Maia, Valéria C.

; Tavares, Valeria

; Costa, Valmir A.

; Amaral, Vanessa S. do

; Silva, Vera C.

; Wolff, Vera R. dos S.

; Slobodian, Verônica

; Silva, Vinícius B. da

; Espíndola, Vinicius C.

; Costa-Silva, Vinicius da

; Bertaco, Vinicius de A.

; Padula, Vinícius

; Ferreira, Vinicius S.

; Silva, Vitor C.P. da

; Piacentini, Vítor de Q.

; Sandoval-Gómez, Vivian E.

; Trevine, Vivian

; Sousa, Viviane R.

; Sant’Anna, Vivianne B. de

; Mathis, Wayne N.

; Souza, Wesley de O.

; Colombo, Wesley D.

; Tomaszewska, Wioletta

; Wosiacki, Wolmar B.

; Ovando, Ximena M.C.

; Leite, Yuri L.R.

Zoologia (Curitiba)

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2024, Volume 41 elocation e24005

Abstract: En | Text: En | PDF: En

ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7

https://doi.org/10.1590/s1984-4689.v41.e24005

Re: “Molecular analysis of 9 unrelated families presenting with juvenile and chronic GM1 gangliosidosis” Re Molecular GM gangliosidosis
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Steiner, Carlos Eduardo

; Bonadia, Luciana Cardoso

Journal of Inborn Errors of Metabolism and Screening

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2024, Volume 12 elocation e20230017

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/2326-4594-jiems-2023-0017

Optimization of Hydrolysis and Identifcation of Bioactive Peptides in Brewery Yeast Residuals
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Rosa, Fernanda A. Della

; Tonin, Angelica P.

; Rocha, Beatriz S.

; Santos, Marco A. R.

; Silveira, Fabiane M.

; Cardoso-Filho, Lucio

; Ribeiro, Valquíria M. S.

; Meurer, Eduardo C.

Journal of the Brazilian Chemical Society

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2024, Volume 35 N. 3 elocation e-20230146

Abstract: En | Text: En | PDF: En

Industrial waste products are of biotechnological interest due to their abundance and can be utilized as protein sources for the production of bioactive peptides through hydrolysis. The utilization of yeast residues from the brewing industry has been demonstrated to be a viable method for obtaining protein hydrolysates. The degree of hydrolysis and soluble total protein of the hydrolysates were evaluated for optimization purposes to achieve a product with a high proportion of soluble organic nitrogen, increased levels of bioactive peptides and amino acids. Both alkaline and enzymatic hydrolysis processes were tested. The hydrolyses were carried out with the aim of large-scale implementation. The treatments were effective in liberating intracellular content and producing biologically functional hydrolysates, with degree of hydrolysis values ranging from 28 to 63% and total protein from 2.95 to 8.28% at the optimum points confrmed by statistical analysis (analysis of variance (ANOVA)). The hydrolysate produced with Alcalase® exhibited the highest peptide intensity, while the hydrolysate produced with Flavourzyme® showed the highest concentration of free amino acids. The peptides were identifed by mass spectrometry and were found to have biological activities according to the Biopep database. This study presents a quick and economically feasible approach for the implementation of a pilot project for the reuse of this waste. nitrogen acids tested largescale large scale 2 63 295 95 2.9 828 8 8.28 ANOVA. ANOVA . (ANOVA)) Alcalase intensity Flavourzyme database 6 29 9 2. 82 8.2 (ANOVA) 8. (ANOVA

https://doi.org/10.21577/0103-5053.20230146

10.

Modulation of tumor plasticity by senescent cells: Deciphering basic mechanisms and survival pathways to unravel therapeutic options cells
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Silva, Andrew Oliveira

; Bitencourt, Thais Cardoso

; Vargas, Jose Eduardo

; Fraga, Lucas Rosa

; Filippi-Chiela, Eduardo

Genetics and Molecular Biology

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2024, Volume 47 Suppl. 1 elocation e20230311

Abstract: En | Text: En | PDF: En

Abstract Senescence is a cellular state in which the cell loses its proliferative capacity, often irreversibly. Physiologically, it occurs due to a limited capacity of cell division associated with telomere shortening, the so-called replicative senescence. It can also be induced early due to DNA damage, oncogenic activation, oxidative stress, or damage to other cellular components (collectively named induced senescence). Tumor cells acquire the ability to bypass replicative senescence, thus ensuring the replicative immortality, a hallmark of cancer. Many anti-cancer therapies, however, can lead tumor cells to induced senescence. Initially, this response leads to a slowdown in tumor growth. However, the longstanding accumulation of senescent cells (SnCs) in tumors can promote neoplastic progression due to the enrichment of numerous molecules and extracellular vesicles that constitutes the senescence-associated secretory phenotype (SASP). Among other effects, SASP can potentiate or unlock the tumor plasticity and phenotypic transitions, another hallmark of cancer. This review discusses how SnCs can fuel mechanisms that underlie cancer plasticity, like cell differentiation, stemness, reprogramming, and epithelial-mesenchymal transition. We also discuss the main molecular mechanisms that make SnCs resistant to cell death, and potential strategies to target SnCs. At the end, we raise open questions and clinically relevant perspectives in the field. irreversibly Physiologically shortening socalled so called senescence activation stress collectively . senescence) immortality anticancer anti therapies however Initially growth However (SnCs senescenceassociated SASP. (SASP) effects transitions differentiation stemness reprogramming epithelialmesenchymal epithelial mesenchymal transition death end field (SASP

https://doi.org/10.1590/1678-4685-gmb-2023-0311

11.

Effect of using tannin extract from Acacia mearnsii on intravaginal temperature, production and milk composition of Holstein cows in a subtropical environment temperature
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Vieira, Laura Valadão

; Cardoso, Kauani Borges

; Cardoso, Jordani Borges

; Halfen, Jéssica

; Barbosa, Antônio Amaral

; Malaguez, Edgard Gonçalves

; Brauner, Cássio Cassal

; Corrêa, Marcio Nunes

; Schmitt, Eduardo

; Pino, Francisco Augusto Burkert Del

Ciência Rural

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2024, Volume 54 N. 9 elocation e20230367

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT: This study evaluated the effect of tannin extract from Acacia mearnsii on intravaginal temperature, production and milk composition of Holstein cows in a subtropical environment. The study period was 29 days and 20 multiparous Holstein cows were selected with an average milk production of 50 ± 6 kg/day and 147 ± 83 days in milk. The cows were separated into two treatments: Control (n = 10) did not receive dietary supplementation. Tannin (n = 10) received Condensed Tannin (Tanac S.A., Montenegro, RS, Brazil) at a dose of 0.19% dry matter (40 g/cow/day). Animals were monitored for milk production and composition as well as intravaginal temperature. The environmental temperature and humidity index (THI) were monitored. The mean THI was 72.39 ± 0.69. The mean intravaginal temperature was 39.17 ± 0.14 °C in the Tannin treatment and 39.03 ± 0.14°C in the Control treatment (P > 0.05). The animals in the Tannin treatment exhibited an intravaginal temperature of 39.2 °C at THI 69.38, and the Control treatment exhibited the same temperature at THI 70.16 (receiver operating characteristic (ROC); P < 0.01). Milk production was higher in the Tannin treatment than in the Control treatment (51.38 ± 0.90 kg/day and 49.94 ± 1.05 kg/day, respectively; P < 0.01). The protein content in milk was higher in the Tannin treatment than in the Control treatment (3.20 ± 0.01% and 3.04 ± 0.01%; respectively; P < 0.01). The results of this study suggested that tannin extract from Acacia mearnsii can attenuate heat stress and its negative effects on animal production. ABSTRACT environment 2 5 kgday kg day 14 8 treatments n 10 supplementation Tanac SA S A S.A. Montenegro RS Brazil 019 0 19 0.19 40 (4 g/cow/day. gcowday g/cow/day . g cow g/cow/day) (THI 7239 72 39 72.3 069 69 0.69 3917 17 39.1 014 0.1 C 3903 03 39.0 014C 0.05. 005 0.05 05 0.05) 392 39. 6938 38 69.38 7016 70 16 70.1 receiver ROC (ROC) 0.01. 001 0.01 01 0.01) 51.38 5138 51 (51.3 090 90 0.9 4994 49 94 49.9 105 1 1.0 respectively 3.20 320 3 (3.2 304 04 3.0 S.A 4 ( 723 7 72. 06 0.6 391 0. 390 00 0.0 693 69.3 701 70. (ROC 51.3 513 (51. 09 9 499 49. 1. 3.2 32 (3. 30 3. 69. 51. (51 (3 (5

RESUMO: Este estudo avaliou o efeito do extrato de tanino de Acacia mearnsii na temperatura intravaginal, na produção e na composição do leite de vacas Holandesas mantidas em ambiente subtropical. O período de estudo foi de 29 dias e foram selecionadas 20 vacas multíparas Holandesas com produção média de leite de 50 ± 6 kg/dia e 147 ± 83 dias em leite. As vacas foram separadas em dois tratamentos: Controle (n = 10) não recebeu suplementação alimentar. Tanino (n = 10) recebeu Tanino Condensado (Tanac S.A., Montenegro, RS, Brasil) na dose de 0,19% de matéria seca (40 g/vaca/dia). Os animais foram monitorados quanto à produção e composição do leite, bem como à temperatura intravaginal. O índice de temperatura e umidade ambiental (ITU) foi monitorado. O ITU médio foi de 72,39 ± 0,69. A temperatura intravaginal média foi de 39,17 ± 0,14 °C no tratamento Tanino e 39,03 ± 0,14 °C no tratamento Controle (P > 0,05). Os animais do tratamento Tanino exibiram temperatura intravaginal de 39,2°C no ITU 69,38, e o tratamento Controle exibiu a mesma temperatura no ITU 70,16 (característica operacional do receptor (ROC); P < 0,01). A produção de leite foi maior no tratamento Tanino do que no tratamento Controle (51,38 ± 0,90kg/dia e 49,94 ± 1,05kg/dia, respectivamente; P < 0,01). O teor de proteína no leite foi maior no tratamento Tanino do que no tratamento Controle (3,20 ± 0,01% e 3,04 ± 0,01%; respectivamente; P < 0,01). Os resultados deste estudo sugerem que o extrato de tanino de Acacia mearnsii pode atenuar o estresse térmico e seus efeitos negativos na produtividade animal. RESUMO subtropical 2 5 kgdia kg dia 14 8 tratamentos n 10 alimentar Tanac SA S S.A. Montenegro RS Brasil 019 0 19 0,19 40 (4 g/vaca/dia. gvacadia g/vaca/dia . g vaca g/vaca/dia) (ITU monitorado 7239 72 39 72,3 069 69 0,69 3917 17 39,1 014 0,1 C 3903 03 39,0 0,05. 005 0,05 05 0,05) 392C 6938 38 69,38 7016 70 16 70,1 característica ROC (ROC) 0,01. 001 0,01 01 0,01) 51,38 5138 51 (51,3 090kgdia 90kg 4994 49 94 49,9 105kgdia 1 05kg 1,05kg/dia respectivamente 3,20 320 3 (3,2 304 04 3,0 animal S.A 4 ( 723 7 72, 06 0,6 391 39, 0, 390 00 0,0 693 69,3 701 70, (ROC 51,3 513 (51, 499 9 49, 3,2 32 (3, 30 3, 69, 51, (51 (3 (5

https://doi.org/10.1590/0103-8478cr20230367

12.

Effects of systemic ozone administration on the fresh extraction sockets healing: a histomorphometric and immunohistochemical study in rats healing
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MIYASAWA, Erton Massamitsu

; ERVOLINO, Edilson

; CARDOSO, Jânderson de Medeiros

; THEODORO, Leticia Helena

; SILVEIRA, Glauco Rodrigues Carmo

; MOLON, Rafael Scaf de

; LEVIN, Liran

; GARCIA, Valdir Gouveia

; PADOVAN, Luis Eduardo Marques

Journal of Applied Oral Science

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2024, Volume 32 elocation e20230412

Abstract: En | Text: En | PDF: En

Abstract Studies have highlighted numerous benefits of ozone therapy in the field of medicine and dentistry, including its antimicrobial efficacy against various pathogenic microorganisms, its ability to modulate the immune system effectively, reduce inflammation, prevent hypoxia, and support tissue regeneration. However, its effects on dental extraction healing remain to be elucidated. Objective Therefore, this study aimed to evaluate the effects of systemically administered ozone (O3) at different doses in the healing of dental extraction sockets in rats. Methodology To this end, 72 Wistar rats were randomly divided into four groups after extraction of the right upper central incisor: Group C – control, no systemic treatment; Group OZ0.3 – animals received a single dose of 0.3 mg/kg O3; Group OZ0.7 – a single dose of 0.7 mg/kg O3; and Group OZ1.0 – a single dose of 1.0 mg/kg O3, intraperitoneally. In total, six animals from each group were euthanized at 7, 14, and 21 days after the commencement of treatment. Bone samples were harvested and further analyzed by descriptive histology, histomorphometry, and immunohistochemistry for osteocalcin (OCN) and tartrate-resistant acid phosphatase (TRAP) protein expression. Results All applied doses of O3 were shown to increase the percentage of bone tissue (PBT) after 21 days compared to group C. After 14 days, the OZ0.7 and OZ1.0 groups showed significantly higher PBT when compared to group C. The OZ1.0 group presented the most beneficial results regarding PBT among groups, which denotes a dose-dependent response. OCN immunostaining was higher in all groups at 21 days. However, after seven and 14 days, the OZ1.0 group showed a significant increase in OCN immunostaining compared to C group. No differences in TRAP+ osteoclasts were found between groups and time points. Conclusion Therefore, O3 therapy at higher doses might be beneficial for bone repair of the alveolar socket following tooth extraction. dentistry microorganisms effectively inflammation hypoxia regeneration However elucidated Therefore O (O3 end 7 incisor control treatment OZ03 OZ OZ0 3 OZ0. 03 0 0. mgkg mg kg OZ07 07 OZ10 OZ1 OZ1. 10 1 1. intraperitoneally total 2 histology histomorphometry (OCN tartrateresistant tartrate resistant TRAP (TRAP expression (PBT dosedependent dependent response points (O

https://doi.org/10.1590/1678-7757-2023-0412

13.

Curva de Aprendizagem da Mortalidade Hospitalar da Substituição da Válvula Aórtica Transcateter: Insights do Registro Nacional Brasileiro Transcateter
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Bernardi, Fernando Luiz de Melo

; Abizaid, Alexandre A.

; Brito Jr, Fábio Sândoli de

; Lemos, Pedro A.

; Siqueira, Dimytri Alexandre Alvim de

; Costa, Ricardo Alves

; Leite, Rogério Eduardo Gomes Sarmento

; Mangione, Fernanda Marinho

; Thiago, Luiz Eduardo Koenig São

; Mangione, José A.

; Lima, Valter Correia de

; Oliveira, Adriano Dourado

; Marino, Marcos Antônio

; Cardoso, Carlos José Francisco

; Caramori, Paulo R. A.

; Tumelero, Rogério

; Portela, Antenor Lages Fortes

; Prudente, Mauricio

; Henriques, Leônidas Alvarenga

; Souza, Fabio Solano

; Bezerra, Cristiano Guedes

; Prado Jr, Guy F. A.

; Freitas, Leandro Zacaris Figueiredo

; Nogueira, Ederlon Ferreira

; Meireles, George César Ximenes

; Pope, Renato Bastos

; Guerios, Enio

; Andrade, Pedro Beraldo de

; Santos, Luciano de Moura

; Marchi, Mauricio Felippi de Sá

; Fundão, Nelson Henrique Fantin

; Ribeiro, Henrique Barbosa

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 N. 7 elocation e20230622

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background Robust data on the learning curve (LC) of transcatheter aortic valve replacement (TAVR) are lacking in developing countries. Objective To assess TAVR’s LC in Brazil over time. Methods We analyzed data from the Brazilian TAVR registry from 2008 to 2023. Patients from each center were numbered chronologically in case sequence numbers (CSNs). LC was performed using restricted cubic splines adjusted for EuroSCORE-II and the use of new-generation prostheses. Also, in-hospital outcomes were compared between groups defined according to the level of experience based on the CSN: 1st to 40th (initial-experience), 41st to 80th (early-experience), 81st to 120th (intermediate-experience), and over 121st (high-experience). Additional analysis was performed grouping hospitals according to the number of cases treated before 2014 (>40 and ≤40 procedures). The level of significance adopted was <0.05. Results A total of 3,194 patients from 25 centers were included. Mean age and EuroSCORE II were 80.7±8.1 years and 7±7.1, respectively. LC analysis demonstrated a drop in adjusted in-hospital mortality after treating 40 patients. A leveling off of the curve was observed after case #118. In-hospital mortality across the groups was 8.6%, 7.7%, 5.9%, and 3.7% for initial-, early-, intermediate-, and high-experience, respectively (p<0.001). High experience independently predicted lower mortality (OR 0.57, p=0.013 vs. initial experience). Low-volume centers before 2014 showed no significant decrease in the likelihood of death with gained experience, whereas high-volume centers had a continuous improvement after case #10. Conclusion A TAVR LC phenomenon was observed for in-hospital mortality in Brazil. This effect was more pronounced in centers that treated their first 40 cases before 2014 than those that reached this milestone after 2014. (LC (TAVR countries TAVRs s time 200 2023 CSNs. CSNs . (CSNs) EuroSCOREII newgeneration new generation prostheses Also inhospital hospital CSN st th initialexperience, initialexperience , (initial-experience) earlyexperience, earlyexperience early (early-experience) intermediateexperience, intermediateexperience intermediate (intermediate-experience) highexperience. highexperience high (high-experience) 201 >40 (>4 ≤4 procedures. procedures procedures) 005 0 05 <0.05 3194 3 194 3,19 2 included 80781 80 7 8 1 80.7±8. 771 7±7.1 4 118 #118 Inhospital In 86 6 8.6% 77 7.7% 59 5 9 5.9% 37 3.7 initial, initial- early, early- intermediate, intermediate- highexperience, high-experience p<0.001. p0001 p p<0.001 001 (p<0.001) OR 057 57 0.57 p0013 013 p=0.01 vs experience. experience) Lowvolume Low volume highvolume 10 #10 20 202 (CSNs (initial-experience (early-experience (intermediate-experience (high-experience >4 (> ≤ 00 <0.0 319 19 3,1 8078 80.7±8 7±7. 11 #11 8.6 7.7 5.9 3. p000 p<0.00 (p<0.001 0.5 p001 01 p=0.0 #1 > ( <0. 31 3, 807 80.7± 7±7 8. 7. 5. p00 p<0.0 (p<0.00 0. p=0. # <0 80.7 7± p0 p<0. (p<0.0 p=0 < 80. p<0 (p<0. p= p< (p<0 (p< (p

Resumo Fundamento Dados robustos sobre a curva de aprendizagem (LC) da substituição da válvula aórtica transcateter (TAVR) são escassos nos países em desenvolvimento. Objetivo Avaliar a LC da TAVR no Brasil ao longo do tempo. Métodos Analisamos dados do registro brasileiro de TAVR de 2008 a 2023. Pacientes de cada centro foram numerados cronologicamente em número sequencial de caso (NSC). A LC foi realizada usando um spline cúbico restrito ajustado para o EuroSCORE-II e o uso de próteses de nova geração. Ainda, os desfechos hospitalares foram comparados entre grupos definidos de acordo com o nível de experiência, com base no NSC: 1º ao 40º caso (experiência inicial), 41º ao 80º caso (experiência básica), 81º ao 120º caso (experiência intermediária) e 121º caso em diante (experiência alta). Análises adicionais foram conduzidas de acordo com o número de casos tratados antes de 2014 (>40 e ≤40 procedimentos). O nível de significância adotado foi p <0,05. Resultados Foram incluídos 3194 pacientes de 25 centros. A idade média foi 80,7±8,1 anos e o EuroSCORE II médio foi 7±7,1. A análise da LC demonstrou uma queda na mortalidade hospitalar ajustada após o tratamento de 40 pacientes. Um patamar de nivelamento na curva foi observado após o caso 118. A mortalidade hospitalar entre os grupos foi 8,6%, 7,7%, 5,9%, e 3,7% para experiência inicial, básica, intermediária e alta, respectivamente (p<0,001). A experiência alta foi preditora independente de mortalidade mais baixa (OR 0,57, p=0,013 vs. experiência inicial). Centros com baixo volume de casos antes de 2014 não mostraram uma redução significativa na probabilidade de morte com o ganho de experiência, enquanto centros com alto volume de casos antes de 2014 apresentaram uma melhora contínua após o caso de número 10. Conclusão Observou-se um fenômeno de LC para a mortalidade hospitalar do TAVR no Brasil. Esse efeito foi mais pronunciado em centros que trataram seus 40 primeiros casos antes de 2014 que naqueles que o fizeram após 2014. (LC (TAVR desenvolvimento tempo 200 2023 NSC. NSC . (NSC) EuroSCOREII geração Ainda º inicial , inicial) básica básica) alta. alta) 201 >40 (>4 ≤4 procedimentos. procedimentos procedimentos) 005 0 05 <0,05 319 2 80781 80 7 8 1 80,7±8, 771 7±7,1 4 118 86 6 8,6% 77 7,7% 59 5 9 5,9% 37 3 3,7 p<0,001. p0001 p<0,001 001 (p<0,001) OR 057 57 0,57 p0013 013 p=0,01 vs inicial. 10 Observouse Observou se 20 202 (NSC >4 (> ≤ 00 <0,0 31 8078 80,7±8 7±7, 11 8,6 7,7 5,9 3, p000 p<0,00 (p<0,001 0,5 p001 01 p=0,0 > ( <0, 807 80,7± 7±7 8, 7, 5, p00 p<0,0 (p<0,00 0, p=0, <0 80,7 7± p0 p<0, (p<0,0 p=0 < 80, p<0 (p<0, p= p< (p<0 (p< (p

https://doi.org/10.36660/abc.20230622

14.

Diretriz sobre Diagnóstico e Tratamento da Cardiomiopatia Hipertrófica – 2024 202 20 2
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Fernandes, Fabio

; Simões, Marcus V.

; Correia, Edileide de Barros

; Marcondes-Braga, Fabiana Goulart

; Coelho-Filho, Otavio Rizzi

; Mesquita, Cláudio Tinoco

; Mathias Junior, Wilson

; Antunes, Murillo de Oliveira

; Arteaga-Fernández, Edmundo

; Rochitte, Carlos Eduardo

; Ramires, Felix José Alvarez

; Alves, Silvia Marinho Martins

; Montera, Marcelo Westerlund

; Lopes, Renato Delascio

; Oliveira Junior, Mucio Tavares de

; Scolari, Fernando Luis

; Avila, Walkiria Samuel

; Canesin, Manoel Fernandes

; Bocchi, Edimar Alcides

; Bacal, Fernando

; Moura, Lidia Zytynski

; Saad, Eduardo Benchimol

; Scanavacca, Mauricio Ibrahim

; Valdigem, Bruno Pereira

; Cano, Manuel Nicolas

; Abizaid, Alexandre Antonio Cunha

; Ribeiro, Henrique Barbosa

; Lemos Neto, Pedro Alves

; Ribeiro, Gustavo Calado de Aguiar

; Jatene, Fabio Biscegli

; Dias, Ricardo Ribeiro

; Beck-da-Silva, Luis

; Rohde, Luis Eduardo Paim

; Bittencourt, Marcelo Imbroinise

; Pereira, Alexandre da Costa

; Krieger, José Eduardo

; Villacorta Junior, Humberto

; Martins, Wolney de Andrade

; Figueiredo Neto, José Albuquerque de

; Cardoso, Juliano Novaes

; Pastore, Carlos Alberto

; Jatene, Ieda Biscegli

; Tanaka, Ana Cristina Sayuri

; Hotta, Viviane Tiemi

; Romano, Minna Moreira Dias

; Albuquerque, Denilson Campos de

; Mourilhe-Rocha, Ricardo

; Hajjar, Ludhmila Abrahão

; Brito Junior, Fabio Sandoli de

; Caramelli, Bruno

; Calderaro, Daniela

; Farsky, Pedro Silvio

; Colafranceschi, Alexandre Siciliano

; Pinto, Ibraim Masciarelli Francisco

; Vieira, Marcelo Luiz Campos

; Danzmann, Luiz Claudio

; Barberato, Silvio Henrique

; Mady, Charles

; Martinelli Filho, Martino

; Torbey, Ana Flavia Malheiros

; Schwartzmann, Pedro Vellosa

; Macedo, Ariane Vieira Scarlatelli

; Ferreira, Silvia Moreira Ayub

; Schmidt, Andre

; Melo, Marcelo Dantas Tavares de

; Lima Filho, Moysés Oliveira

; Sposito, Andrei C.

; Brito, Flávio de Souza

; Biolo, Andreia

; Madrini Junior, Vagner

; Rizk, Stephanie Itala

; Mesquita, Evandro Tinoco

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 N. 7 elocation e202400415

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20240415

15.

Supplementation with increasing doses of selenium associated with vitamin E in the treatment of bovines with enzootic hematuria
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Moreira Júnior, Carlos A.

; Oliveira, Eduardo V.

; Cardoso, Caio. A.

; Miranda, Marcos P.B.

; Guedes, Natália A.

; Burak, Diego L.

; Pfister, James A.

; Nunes, Louisiane C.

Pesquisa Veterinária Brasileira

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2024, Volume 44 elocation e07349

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: A hematúria enzoótica bovina (HEB) é uma forma clínica da intoxicação em bovinos causada pelo consumo de Pteridium sp. (samambaia) que não possui tratamento. Contudo, a suplementação utilizando selênio (Se) e vitamina E tem se mostrado viável. Objetivou-se avaliar os efeitos da suplementação com doses crescentes de selênio associado à vitamina E em bovinos com HEB, bem como, comparar os níveis de selênio em sangue total e soro sanguíneo, avaliar a atividade de glutationa peroxidase, os níveis de antioxidantes totais e a atividade relativa da enzima monoamina oxidase (MAO). Suplementou-se durante 13 semanas, por via parenteral, quatro grupos de bovinos com hematúria enzoótica (HEB), com doses crescentes de Se: Grupo controle, Grupo tratamento 1 (0,05mg/kg de Se), Grupo tratamento 2 (0,1mg/kg de Se) e Grupo tratamento 3 (0,2mg/kg de Se). Todos os grupos receberam em associação 500mg/animal de vitamina E. Quinzenalmente foram avaliadas as variáveis peso, intensidade de hematúria, hematócrito, proteína plasmática total, fibrinogênio plasmático, atividade sanguínea de glutationa peroxidase, níveis de antioxidantes totais, concentração sanguíneas de selênio e atividade relativa de monoamina oxidase. Utilizou-se os testes Kruskal Wallis e Friedman (P<0,05), para avaliar os efeitos dos tratamentos e do tempo, respectivamente, ambos seguidos do teste de comparação múltipla de Dunn. Para as variáveis peso, antioxidantes totais e atividade relativa de monoamina oxidase não houve diferença entre os tratamentos (P>0,05) e houve diferença ao longo do tempo (P<0,05). Para hematúria e hematócrito, houve diferença entre os tratamentos (P<0,05) e não houve diferença ao longo do tempo (P>0,05). Para a variável glutationa peroxidase, não houve diferença significativa entre os tratamentos (P>0,05), porém houve diferença entre os momentos M8 e M14, no Grupo tratamento 3 (P<0,05). Para proteína plasmática total e fibrinogênio não houve diferenças entre os tratamentos e nem ao longo do tempo (P>0,05). Os níveis de Se foram maiores no Grupo tratamento 1 atingindo a maior concentração no momento M8 no soro sanguíneo (235,3µg/L). Portanto, a suplementação com selênio na dose de 0,05mg/kg associada à vitamina E melhorou o quadro clínico de hematúria, mas não interferiu na atividade da glutationa peroxidase e nos níveis de antioxidantes totais. A atividade da monoamina oxidase foi reduzida globalmente pela suplementação de vitamina E. Estes resultados indicam que o soro foi o melhor local para medir o selênio. RESUMO HEB (HEB sp samambaia (samambaia Contudo (Se viável Objetivouse Objetivou como MAO. MAO . (MAO) Suplementouse Suplementou semanas parenteral , controle 005mgkg mgkg 0 05mg kg mg Se, 0,1mg/kg 01mgkg 1mg 0,2mg/kg 02mgkg 2mg Se. 500mganimal mganimal 500mg animal peso hematócrito plasmático Utilizouse Utilizou P<0,05, P005 P P<0,05 05 respectivamente Dunn P>0,05 (P>0,05 P<0,05. (P<0,05 P>0,05. P>0,05, M M14 235,3µg/L. 2353µgL µgL 235,3µg/L 235 3µg L µg (235,3µg/L) Portanto (MAO P00 P<0,0 P>0,0 (P>0,0 (P<0,0 M1 23 (235,3µg/L P0 P<0, P>0, (P>0, (P<0, P<0 P>0 (P>0 (P<0 P< P> (P> (P< (P

ABSTRACT: Bovine enzootic hematuria (BEH) is a clinical form of poisoning in cattle caused by the consumption of Pteridium spp. (bracken fern), which has no treatment. However, selenium (Se) and vitamin E supplementation are feasible. The aim of this study was to evaluate the effects of supplementation with increasing doses of selenium associated with vitamin E in cattle with BEH, compare the levels of Se in whole blood and blood serum, and evaluate the activity of glutathione peroxidase, total antioxidants, and the relative activity of the enzyme monoamine oxidase (MAO). Four groups of cattle with BEH were supplemented parenterally for 13 weeks with increasing doses of Se: Control group, Treatment group 1 (0.05mg/kg), Treatment group 2 (0.1mg/kg), and Treatment group 3 (0.2mg/kg). All groups received 500mg of vitamin E in combination with the Se supplementation. The measured variables included weight, hematuria intensity, hematocrit, total plasma protein, plasma fibrinogen, blood glutathione peroxidase activity, and total antioxidant levels. The blood concentrations of Se and relative MAO activity were evaluated every two weeks. Kruskal-Wallis and Friedman tests (P<0.05) were used to assess treatment and time effects, respectively, followed by Dunn’s multiple comparison test. For weight, total antioxidant concentration, and relative MAO, there was no significant difference (P>0.05) between the treatments, but there was a significant difference over time (P<0.05). For hematuria and hematocrit, there were significant treatment differences (P<0.05) but no significant time differences (P>0.05). For glutathione peroxidase, there was no significant difference (P>0.05) among the treatments, but there was a significant difference (P<0.05) between treatments M8 and M14 in Treatment group 3. There were no differences in the total plasma protein and fibrinogen levels between treatments or over time (P>0.05). Selenium levels were higher in Treatment group 1, reaching the highest concentration (235.3µg/L) in the blood serum at eight weeks. Therefore, supplementation with Se at a dose of 0.05mg/kg associated with vitamin E improved the clinical condition of hematuria but did not interfere with glutathione peroxidase activity or with levels of total antioxidants. MAO activity was reduced by vitamin E supplementation. These results indicate that the serum is the best site for measuring Se levels. ABSTRACT (BEH spp bracken fern, fern , fern) However (Se feasible antioxidants MAO. . (MAO) 0.05mg/kg, 005mgkg mgkg 0 05mg kg mg (0.05mg/kg) 0.1mg/kg, 01mgkg 0.1mg/kg 1mg (0.1mg/kg) 0.2mg/kg. 02mgkg 0.2mg/kg 2mg (0.2mg/kg) weight intensity hematocrit KruskalWallis Kruskal Wallis P<0.05 P005 P 05 (P<0.05 respectively Dunns Dunn s test P>0.05 (P>0.05 P<0.05. P>0.05. M M1 235.3µg/L 2353µgL µgL 235 3µg L µg (235.3µg/L Therefore (MAO (0.05mg/kg (0.1mg/kg (0.2mg/kg P<0.0 P00 (P<0.0 P>0.0 (P>0.0 23 P<0. P0 (P<0. P>0. (P>0. P<0 (P<0 P>0 (P>0 P< (P< P> (P> (P

https://doi.org/10.1590/1678-5150-pvb-7349

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