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Da Individuação à Cumulatividade: a incorporação nominal em Tenetehára (Tupí-Guaraní)
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Castro, Ricardo Campos

; Camargos, Quesler Fagundes

DELTA: Documentação de Estudos em Lingüística Teórica e Aplicada

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2023, Volume 39 N. 2 elocation 202339248182

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT To express individuation and cumulativity, natural languages present a significant diversity of grammatical mechanisms that involve lexical, morphological, and syntactic strategies. We intend to demonstrate that, in the Tenetehára language (Tupí-Guaraní), noun incorporation is one of these resources. In this regard, we discuss the syntactic operation of incorporation, which expresses a low degree of individuation of the incorporated term, in addition to resulting in nouns with a cumulative interpretation. Although, for example, there are no articles in this language that can denote definiteness or specificity, non-incorporated objects present a greater degree of individuation when they are contrasted with their incorporated versions. The analysis proposed here is based on elicited linguistic data that comprise the two strategies of noun incorporation in this language: (i) noun incorporation with valence reduction, which involves incorporation of the object of transitive verbs; and (ii) incorporation without valence reduction, which concerns the incorporation of the possessed constituent of noun phrases in the syntactic function of subject of intransitive verbs and object of transitive verbs.

RESUMO Para expressar individuação e cumulatividade, as línguas naturais apresentam uma significativa diversidade de mecanismos gramaticais que envolvem estratégias lexicais, morfológicas e sintáticas. Pretendemos demonstrar que, na língua Tenetehára (Tupí-Guaraní), a incorporação nominal constitui-se como um desses recursos. Para isso, será discutida essa operação sintática, que expressa baixo grau de individuação do termo incorporado, além de resultar ainda em nomes com uma interpretação cumulativa. Embora não haja, por exemplo, artigos nessa língua que possam denotar definitude ou especificidade, objetos não incorporados apresentam maior grau de individuação quando são contrastados com suas versões incorporadas. A análise aqui proposta se fundamenta em dados linguísticos elicitados que compreendem as duas estratégias de incorporação nominal nessa língua: (i) incorporação nominal com redução de valência, que envolve a incorporação do objeto de verbos transitivos; e (ii) incorporação sem diminuição de valência, que diz respeito à incorporação do termo possuído de sintagmas nominais na função sintática de sujeito de verbos intransitivos e objeto de transitivos.

https://doi.org/10.1590/1678-460x202339248182

Lesão Miocárdica e Prognóstico em Pacientes Hospitalizados com COVID-19 no Brasil: Resultados do Registro Nacional de COVID-19
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Barbosa, Hannah Cardoso

; Martins, Maria Auxiliadora Parreiras

; Jesus, Jordana Cristina de

; Meira, Karina Cardoso

; Passaglia, Luiz Guilherme

; Sacioto, Manuela Furtado

; Bezerra, Adriana Falangola Benjamin

; Schwarzbold, Alexandre Vargas

; Maurílio, Amanda de Oliveira

; Farace, Barbara Lopes

; Silva, Carla Thais Cândida Alves da

; Cimini, Christiane Corrêa Rodrigues

; Silveira, Daniel Vitorio

; Carazai, Daniela do Reis

; Ponce, Daniela

; Costa, Emanuel Victor Alves

; Manenti, Euler Roberto Fernandes

; Cenci, Evelin Paola de Almeida

; Bartolazzi, Frederico

; Madeira, Glícia Cristina de Castro

; Nascimento, Guilherme Fagundes

; Velloso, Isabela Vasconcellos Pires

; Batista, Joanna d’Arc Lyra

; Morais, Júlia Drumond Parreiras de

; Carvalho, Juliana da Silva Nogueira

; Ruschel, Karen Brasil

; Martins, Karina Paula Medeiros Prado

; Zandoná, Liege Barella

; Menezes, Luanna Silva Monteiro

; Kopittke, Luciane

; Castro, Luís César de

; Nasi, Luiz Antônio

; Floriani, Maiara Anschau

; Souza, Maíra Dias

; Carneiro, Marcelo

; Bicalho, Maria Aparecida Camargos

; Lima, Maria Clara Pontello Barbosa

; Godoy, Mariana Frizzo de

; Guimarães-Júnior, Milton Henriques

; Mendes, Paulo Mascarenhas

; Delfino-Pereira, Polianna

; Ribeiro, Raquel Jaqueline Eder

; Finger, Renan Goulart

; Menezes, Rochele Mosmann

; Francisco, Saionara Cristina

; Araújo, Silvia Ferreira

; Oliveira, Talita Fischer

; Oliveira, Thainara Conceição de

; Polanczyk, Carisi Anne

; Marcolino, Milena Soriano

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 2 elocation e20220151

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background Cardiovascular complications of COVID-19 are important aspects of the disease’s pathogenesis and prognosis. Evidence on the prognostic role of troponin and myocardial injury in Latin American hospitalized COVID-19 patients is still scarce. Objectives To evaluate myocardial injury as independent predictor of in-hospital mortality and invasive mechanical ventilation support in hospitalized patients, from the Brazilian COVID-19 Registry. Methods This cohort study is a substudy of the Brazilian COVID-19 Registry, conducted in 31 Brazilian hospitals of 17 cities, March-September 2020. Primary outcomes included in-hospital mortality and invasive mechanical ventilation support. Models for the primary outcomes were estimated by Poisson regression with robust variance, with statistical significance of p<0.05. Results Of 2,925 patients (median age of 60 years [48-71], 57.1% men), 27.3% presented myocardial injury. The proportion of patients with comorbidities was higher among patients with cardiac injury (median 2 [1-2] vs. 1 [0-2]). Patients with myocardial injury had higher median levels of brain natriuretic peptide, lactate dehydrogenase, creatine phosphokinase, N-terminal pro-brain natriuretic peptide, and C-reactive protein than patients without myocardial injury. As independent predictors, C-reactive protein and platelet counts were related to the risk of death, and neutrophils and platelet counts were related to the risk of invasive mechanical ventilation support. Patients with high troponin levels presented a higher risk of death (RR 2.03, 95% CI 1.60-2.58) and invasive mechanical ventilation support (RR 1.87, 95% CI 1.57-2.23), when compared to those with normal troponin levels. Conclusion Cardiac injury was an independent predictor of in-hospital mortality and the need for invasive mechanical ventilation support in hospitalized COVID-19 patients.

Resumo Fundamento As complicações cardiovasculares da COVID-19 são aspectos importantes da patogênese e do prognóstico da doença. Evidências do papel prognóstico da troponina e da lesão miocárdica em pacientes hospitalizados com COVID-19 na América Latina são ainda escassos. Objetivos Avaliar a lesão miocárdica como preditor independente de mortalidade hospitalar e suporte ventilatório mecânico em pacientes hospitalizados, do registro brasileiro de COVID-19. Métodos Este estudo coorte é um subestudo do registro brasileiro de COVID-19, conduzido em 31 hospitais brasileiros de 17 cidades, de março a setembro de 2020. Os desfechos primários incluíram mortalidade hospitalar e suporte ventilatório mecânico invasivo. Os modelos para os desfechos primários foram estimados por regressão de Poisson com variância robusta, com significância estatística de p<0,05. Resultados Dos 2925 pacientes [idade mediana de 60 anos (48-71), 57,1%], 27,3% apresentaram lesão miocárdica. A proporção de pacientes com comorbidades foi maior nos pacientes com lesão miocárdica [mediana 2 (1-2) vs. 1 (0-20)]. Os pacientes com lesão miocárdica apresentaram maiores valores medianos de peptídeo natriurético cerebral, lactato desidrogenase, creatina fosfoquinase, N-terminal do pró-peptídeo natriurético tipo B e proteína C reativa em comparação a pacientes sem lesão miocárdica. Como fatores independentes, proteína C reativa e contagem de plaquetas foram relacionados com o risco de morte, e neutrófilos e contagem de plaquetas foram relacionados ao risco de suporte ventilatório mecânico invasivo. Os pacientes com níveis elevados de troponina apresentaram um maior risco de morte (RR 2,03, IC95% 1,60-2,58) e suporte ventilatório mecânico (RR 1,87;IC95% 1,57-2,23), em comparação àqueles com níveis de troponina normais. Conclusão Lesão cardíaca foi um preditor independente de mortalidade hospitalar e necessidade de suporte ventilatório mecânico em pacientes hospitalizados com COVID-19.

https://doi.org/10.36660/abc.20220151

Association of salivary alpha-2-macroglobulin with glycemia and glycated hemoglobin in type 2 diabetes mellitus: a systematic review and meta-analysis study
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Caixeta, Douglas Carvalho

; Pennisi, Pedro Rogério Camargos

; Moura, Douglas Vieira

; Nunes, Marjorie Adriane Costa

; Espindola, Foued Salmen

; Blumenberg, Cauane

; Paranhos, Luiz Renato

; Sabino-Silva, Robinson

Sao Paulo Medical Journal

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dec 2022, Volume 140 N. 6 Pages 818 - 828

Abstract: En | Text: En | PDF: En

Abstract BACKGROUND: Chronically elevated alpha-2-macroglobulin (A2MG) in the blood has been correlated with diabetes and the HbA1c profile; however, no systematic review has been conducted to evaluate the association of A2MG salivary levels and glycemia or HbA1c levels in diabetes mellitus type 2 (DM2) patients. OBJECTIVE: To evaluate whether A2MG salivary levels are related to the glycemia or HbA1c levels in DM2 patients. DESIGN AND SETTING: Systematic review developed at Universidade Federal de Uberlândia (UFU), Brazil. METHODS: Eight databases were used as research sources. The eligibility criteria included studies that reported data regarding mean salivary A2MG and the correlation between glycemia and/or HbA1c levels of DM2 subjects (uncontrolled and well-controlled) and non-diabetic subjects. The risk of bias of the studies selected was assessed using the Joanna Briggs Institute (JBI) critical appraisal tools for use in JBI systematic reviews. Pooled correlation coefficients were estimated using the Hunter-Schmidt method. Study estimates were weighted according to their sample size, and heterogeneity was calculated using the chi-square statistic. RESULTS: Four studies on DM2 patients were included in this systematic review after careful analysis of 1482 studies. Three studies compared A2MG with HbA1c and glycemia. Overall, the correlation between A2MG and HbA1c was strong (r = 0.838). In contrast, the correlation between A2MG and glycemia was low (r = 0.354). CONCLUSION: The strong association between HbA1C and salivary A2MG suggests that this salivary protein has the potential to be a surrogate for HbA1C, if corroboratory further evidence is obtained through large-scale studies.

https://doi.org/10.1590/1516-3180.2021.0816.r2.19052022

Tratamento da demência: recomendações do Departamento Científico de Neurologia Cognitiva e do Envelhecimento da Academia Brasileira de Neurologia
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Caramelli, Paulo

; Marinho, Valeska

; Laks, Jerson

; Coletta, Marcus Vinicius Della

; Stella, Florindo

; Camargos, Einstein Francisco

; Smid, Jerusa

; Barbosa, Breno José Alencar Pires

; Schilling, Lucas Porcello

; Balthazar, Marcio Luiz Figueredo

; Frota, Norberto Anízio Ferreira

; Souza, Leonardo Cruz de

; Vale, Francisco Assis Carvalho

; Chaves, Márcia Lorena Fagundes

; Brucki, Sonia Maria Dozzi

; Nitrini, Ricardo

; Durgante, Helen Bedinoto

; Bertolucci, Paulo Henrique Ferreira

Dementia & Neuropsychologia

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sep 2022, Volume 16 N. 3 Pages 88 - 100

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Atualmente não há tratamento curativo para as demências neurodegenerativas ou para a demência vascular, mas algumas intervenções farmacológicas e não farmacológicas podem contribuir para aliviar os sintomas, retardar a progressão da doença e melhorar a qualidade de vida. As abordagens terapêuticas atuais são baseadas na etiologia, no perfil dos sintomas e no estágio da demência. Neste artigo apresentamos recomendações sobre os tratamentos farmacológicos e não farmacológicos da demência devida à doença de Alzheimer, comprometimento cognitivo vascular, demência frontotemporal, demência da doença de Parkinson e demência com corpos de Lewy.

ABSTRACT There is currently no cure for neurodegenerative or vascular dementias, but some pharmacological and non-pharmacological interventions may contribute to alleviate symptoms, slow disease progression and improve quality of life. Current treatment approaches are based on etiology, symptom profile and stage of dementia. This manuscript presents recommendations on pharmacological and non-pharmacological treatments of dementia due to Alzheimer’s disease, vascular cognitive impairment, frontotemporal dementia, Parkinson’s disease dementia, and dementia with Lewy bodies.

https://doi.org/10.1590/1980-5764-dn-2022-s106pt

Risk factors for acute kidney injury after liver transplantation in intensive care unit: a retrospective cohort study
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Neves, Ana Paula Camargos de Figueirêdo

; Gomes, Angélica Gomides dos Reis

; Vassallo, Paula Frizera

; Silva, Ana Cristina Simões e

; Penna, Francisco Guilherme Cancela e

; Bastos, Fabrício de Lima

; Muniz, Mateus Rocha

; Rocha, Guilherme Carvalho

; Santos Júnior, Augusto Cesar Soares dos

; Ravetti, Cecilia Gómez

; Nobre, Vandack

Sao Paulo Medical Journal

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aug 2022, Volume 140 N. 4 Pages 559 - 565

Abstract: En | Text: En | PDF: En

ABSTRACT BACKGROUND: Acute kidney injury (AKI) is a frequent complication during the postoperative period following liver transplantation. Occurrence of AKI in intensive care unit (ICU) patients is associated with increased mortality and higher costs. OBJECTIVE: To evaluate occurrences of moderate or severe AKI among patients admitted to the ICU after liver transplantation and investigate characteristics associated with this complication. DESIGN AND SETTING: Single-center retrospective cohort study in a public hospital, Belo Horizonte, Brazil. METHODS: Forty-nine patients admitted to the ICU between January 2015 and April 2017 were included. AKI was defined from a modified Kidney Disease Improving Global Outcomes (KDIGO) score (i.e. based exclusively on serum creatinine levels). RESULTS: Eighteen patients (36.7%) developed AKI KDIGO 2 or 3; mostly KDIGO 3 (16 out of the 18 patients). Lactate level within the first six hours after ICU admission (odds ratio, OR: 1.3; 95% confidence interval, CI: 1.021-1.717; P = 0.034) and blood transfusion requirement within the first week following transplantation (OR: 8.4; 95% CI: 1.687-41.824; P = 0.009) were independently associated with development of AKI. Patients with AKI KDIGO 2 or 3 underwent more renal replacement therapy (72.2% versus 3.2%; P < 0.01), had longer hospital stay (20 days versus 15 days; P = 0.001), higher in-hospital mortality (44.4% versus 6.5%; P < 0.01) and higher mortality rate after one year (44.4% versus 9.7%; P = 0.01). CONCLUSION: Need for blood transfusion during ICU stay and hyperlactatemia within the first six postoperative hours after liver transplantation are independently associated with moderate or severe AKI. Developing AKI is apparently associated with poor outcomes.

https://doi.org/10.1590/1516-3180.2021.0641.r2.12112021

Bronchoscopy simulation training in the post-pandemic world
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Vieira, Lais Meirelles Nicoliello

; Camargos, Paulo Augusto Moreira

; Ibiapina, Cássio da Cunha

Jornal Brasileiro de Pneumologia

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2022, Volume 48 N. 3 elocation e20210361

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A broncoscopia é um procedimento importante para examinar as vias aéreas. O treinamento tradicional consiste em realizar o procedimento em humanos. Isso traz riscos, embora apenas raramente, e causa estresse nos broncoscopistas em formação. O objetivo deste estudo foi realizar uma revisão da literatura a respeito de simuladores de broncoscopia e seu uso e impacto na educação médica, apresentando perspectivas acerca do uso de simuladores no mundo pós-pandemia. A revisão baseou-se em artigos publicados em inglês em 2000-2021 e recuperados a partir de buscas realizadas nos seguintes bancos de dados: MEDLINE (PubMed), Embase, SciELO e Google Acadêmico. Os simuladores de broncoscopia melhoraram muito ao longo dos anos, permitindo que o processo de ensino e aprendizagem ocorra em um ambiente livre de riscos. O treinamento com simuladores de broncoscopia é uma opção interessante para a avaliação das vias aéreas, principalmente nos próximos anos, já que a pandemia de COVID-19 ressaltou a necessidade de educação médica continuada.

ABSTRACT Bronchoscopy is an important procedure to examine the airways. It is traditionally taught by having trainees perform it in humans. This carries risks, albeit rarely, and causes stress to trainees. The objective of this study was to review bronchoscopy simulators, as well as their use in and impact on medical education, presenting perspectives on the use of simulators in the post-pandemic world. This review was based on articles published in English in 2000-2021 and retrieved from any of the following databases: MEDLINE (PubMed), Embase, SciELO, and Google Scholar. Bronchoscopy simulators have improved markedly over time, allowing the teaching/learning process to take place in a risk-free environment. Bronchoscopy simulation training is an interesting option for the evaluation of the airways, especially in the coming years, with the COVID-19 pandemic highlighting the need for continuing medical education.

https://doi.org/10.36416/1806-3756/e20210361

Association of salivary alpha-2-macroglobulin with glycemia and glycated hemoglobin in type 2 diabetes mellitus: a systematic review and meta-analysis study
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Caixeta, Douglas Carvalho

; Pennisi, Pedro Rogério Camargos

; Moura, Douglas Vieira

; Nunes, Marjorie Adriane Costa

; Espindola, Foued Salmen

; Blumenberg, Cauane

; Paranhos, Luiz Renato

; Sabino-Silva, Robinson

Sao Paulo Medical Journal

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2022, N. ahead

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1516-3180.2021.0816.r2.19052022

Associated factors with recurrent wheezing in infants: is there difference between the sexes?
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Ferreira, Wellington Fernando da Silva

; Carvalho, Denise Siqueira de

; Wandalsen, Gustavo Falbo

; Solé, Dirceu

; Sarinho, Emanuel Sávio Cavalcante

; Medeiros, Décio

; Melo, Ana Carolina Cavalcanti Dela Bianca

; Prestes, Elaine Xavier

; Camargos, Paulo Augusto Moreira

; Luhm, Karin Regina

; Garcia-Marcos, Luis

; Mallol, Javier

; Rosário, Nelson Augusto

; Chong-Neto, Herberto José

Jornal de Pediatria

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dec 2021, Volume 97 N. 6 Pages 629 - 636

Abstract: En | Text: En | PDF: En

Abstract Objective: Identify associated factors for recurrent wheezing (RW) in male and female infants. Methods: Cross-sectional multicentric study using the standardized questionnaire from the Estudio Internacional sobre Sibilancias en Lactantes (EISL). The questionnaire was applied to parents of 9345 infants aged 12-15 months at the time of immunization/routine visits. Results: One thousand two hundred and sixty-one (13.5%) males and nine hundred sixty-three (10.3%) females have had RW (≥3 episodes), respectively (p10 colds episodes (OR = 3.46; IC 95% 2.35-5.07), air pollution (OR = 1.33; IC 95% 1.12-1.59), molds at home (OR = 1.23; IC 95% 1.03-1.47), Afro-descendants (OR = 1.42; IC 95% 1.20-1.69), bronchopneumonia (OR = 1.41; IC; 1.11-1.78), severe episodes of wheezing in the first year (OR = 1.56; IC 95% 1.29-1.89), treatment with bronchodilators (OR = 1.60; IC 95% 1.22-2,1) and treatment with oral corticosteroids (OR = 1,23; IC 95% 0.99-1,52). Associated factors for RW for females were passive smoking (OR = 1.24; IC 95% 1.01-1,51), parents diagnosed with asthma (OR = 1.32; IC 95% 1,08-1,62), parents with allergic rhinitis (OR = 1.26; IC 95% 1.04-1.53), daycare attendance (OR = 1.48; IC 95% 1.17-1,88), colds in the first 6 months of life (OR = 2.19; IC 95% 1.69-2.82), personal diagnosis of asthma (OR = 1.84; IC 95% 1.39-2.44), emergency room visits (OR = 1.78; IC 95% 1.44-2.21), nighttime symptoms (OR = 2.89; IC 95% 2.34-3.53) and updated immunization (OR = 0.62; IC 95% 0.41-0.96). Conclusion: There are differences in associated factors for RW between genders. Identification of these differences could be useful to the approach and management of RW between boys and girls.

https://doi.org/10.1016/j.jped.2021.01.001 1 downloads

Accumulation of macronutrients and productivity of potato with foliar application of biofertilizer
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Pinheiro-Araújo, Lucas

; Camargos de-Oliveira, Roberta

; Quintao-Lana, Regina Maria

; Queiroz-Luz, Jose Magno

; Apolinário-Guimarães, João Paulo

; de Oliveira-Alves, Erlani

International journal of agriculture and natural resources

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aug 2021, Volume 48 N. 2 Pages 70 - 82

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract The addition of organic compounds to fertilizers has shown positive effects on plant metabolism. This study aimed to evaluate the macronutrient accumulation and productivity of potato with the use of biofertilizer (BF) applied to the leaves. A 2×7 factorial plot with a plot subdivided in time and ten replications used two forms of fertilization: a chemical fertilizer with conventional NPK (nitrogen, phosphorus and potassium: control) and conventional fertilizer plus biofertilizers (BF); evaluations were performed 31, 41, 51, 61, 71, 81 and 91 days after planting (DAP) using the Jelly cultivar. The BF increased the maximum N, K, Ca and Mg accumulations in the leaves, especially N and K, with the period of greatest accumulation occurring between 62 and 66 DAP. The accumulations of N, P, K, Ca and Mg in the tubers accelerated from 71 DAP. At the end of the cycle (e.g., 91 DAP), the increases in the nutrient accumulations of N, P, K and Ca were between 30 and 64% higher for the BF application, the Mg accumulations doubled and the S accumulations exhibited no differences between the evaluation periods. For the leaves, the following decreasing sequence of maximum accumulation was observed: K>N>Ca>Mg>S>P. For the tubers, the following decreasing sequence was obtained: K>N>P>Ca>Mg>S. The use of biofertilizers caused higher productivity of tubers of greater caliber and soluble solids contents in the cv. Jelly potato tubers.

Resumen La adición de compuestos orgánicos en fertilizantes ha mostrado un efecto positivo en el metabolismo de las plantas. El objetivo fue evaluar la acumulación de macronutrientes en tubérculos de papa con el uso de biofertilizantes líquidos (BF), aplicados a través de la hoja. El diseño experimental fue factorial 2×7 con una división en el tiempo y diez repeticiones, consistió en dos formas de fertilización: química con NPK convencional (control) y convencionales más biofertilizantes (BF) y evaluaciones en 31; 41; 51; 61; 71; 81 y 91 días después de la siembra (DAS), utilizando el cultivar Jelly. BF favorece las acumulaciones máximas de N, K, Ca y Mg en las hojas, entre 8 y 37%, especialmente para N y K, con un período de mayor acumulación entre 62 y 66 DAP. La acumulación de N, P, K, Ca y Mg en los tubérculos se acelera desde 71 DAP. Al final del ciclo (91 DAP), el aumento en la acumulación de nutrientes N, P, K y Ca es entre 30 y 64% mayor en la aplicación de BF líquido, el Mg se acumula el doble y S no difiere entre los períodos de evaluación. Para las hojas, se obtuvo la siguiente secuencia decreciente de acumulación máxima: K>N>Ca>Mg>S>P. Para los tubérculos, se obtuvo K>N>P>Ca>Mg>S. El sou de biofertilizantes proporciona una mayor productividad de tubérculos de mayor calibre y contenido de sólidos solubles en el papa cv. Jelly.

https://doi.org/10.7764/ijanr.v48i2.2269 75 downloads

10.

Tuberculosis in Brazil: one country, multiple realities
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Cortez, Andreza Oliveira

; Melo, Angelita Cristine de

; Neves, Leonardo de Oliveira

; Resende, Karina Aparecida

; Camargos, Paulo

Jornal Brasileiro de Pneumologia

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2021, Volume 47 N. 2 elocation e20200119

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Identificar os determinantes das variáveis da tuberculose nas diversas regiões do Brasil e avaliar as tendências dessas variáveis ao longo dos dez anos anteriores ao término do prazo definido para os Objetivos de Desenvolvimento do Milênio (ODM) das Nações Unidas. Métodos: Estudo analítico ecológico no qual utilizamos oito bancos de dados públicos nacionais para investigar os 716.971 casos novos de tuberculose notificados entre 2006 e 2015. Resultados: Durante o período estudado, houve ligeiras reduções na prevalência, incidência e mortalidade associadas à tuberculose. O Brasil não atingiu o ODM de mortalidade por tuberculose. Entre os indicadores de desempenho no controle da tuberculose, houve melhora apenas naqueles relacionados a tratamento e abandono de tratamento. Em termos da magnitude da tuberculose, foram observadas diferenças regionais substanciais. A taxa de incidência de tuberculose foi maior na região Norte, assim como a temperatura média anual e a umidade relativa do ar. Essa região também apresentou a segunda menor média do índice de desenvolvimento humano, a menor cobertura de atenção primária à saúde (APS) e o menor número de hospitalizações por tuberculose. A região Nordeste apresentou a maior cobertura de APS, o maior número de hospitalizações por condições sensíveis à atenção primária e a maior taxa de mortalidade por tuberculose. A região Sul apresentou as menores reduções nos indicadores epidemiológicos, juntamente com os maiores aumentos na frequência de abandono de tratamento e de retratamento. A região Centro-Oeste apresentou a menor magnitude geral de tuberculose e melhores indicadores de monitoramento. Conclusões: A situação da tuberculose difere entre as cinco regiões do Brasil. Essas diferenças podem dificultar o controle da doença no país e podem explicar o fato de o Brasil não ter atingido o ODM de mortalidade por tuberculose. As medidas de controle da tuberculose devem ser adaptadas para dar conta das diferenças regionais.

ABSTRACT Objective: To identify the determinants of tuberculosis-related variables in the various regions of Brazil and evaluate trends in those variables over the ten-year period preceding the end of the timeframe defined for the United Nations Millennium Development Goals (MDGs). Methods: This was an ecological analytical study in which we utilized eight national public databases to investigate the 716,971 new tuberculosis cases reported between 2006 and 2015. Results: Over the study period, there were slight reductions in the prevalence, incidence, and mortality associated with tuberculosis. Brazil did not reach the MDG for tuberculosis-related mortality. Among the performance indicators of tuberculosis control, there were improvements only in those related to treatment and treatment abandonment. In terms of the magnitude of tuberculosis, substantial regional differences were observed. The tuberculosis incidence rate was highest in the northern region, as were the annual mean temperature and relative air humidity. That region also had the second lowest human development index, primary health care (PHC) coverage, and number of hospitalizations for tuberculosis. The northeastern region had the highest PHC coverage, number of hospitalizations for primary care-sensitive conditions, and tuberculosis-related mortality rate. The southern region showed the smallest reductions in epidemiological indicators, together with the greatest increases in the frequency of treatment abandonment and retreatment. The central-west region showed the lowest overall magnitude of tuberculosis and better monitoring indicators. Conclusions: The situation related to tuberculosis differs among the five regions of Brazil. Those differences can make it difficult to control the disease in the country and could explain the fact that Brazil failed to reach the MDG for tuberculosis-related mortality. Tuberculosis control measures should be adapted to account for regional differences.

https://doi.org/10.36416/1806-3756/e20200119 1373 downloads

11.

Evidence for current circulation of an ancient West Nile virus strain (NY99) in Brazil
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Siconelli, Márcio Junio Lima

; Jorge, Daniel Macedo de Melo

; Castro-Jorge, Luiza Antunes de

; Fonseca-Júnior, Antônio Augusto

; Nascimento, Mateus Laguardia

; Floriano, Vitor Gonçalves

; Souza, Fransérgio Rocha de

; Queiroz-Júnior, Eudson Maia de

; Camargos, Marcelo Fernandes

; Costa, Eliana Dea Lara

; Carvalho, Adolorata Aparecida Bianco

; Fonseca, Benedito Antonio Lopes da

Revista da Sociedade Brasileira de Medicina Tropical

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2021, Volume 54 elocation e0687-2020

Abstract: En | Text: En | PDF: En

Abstract INTRODUCTION: In Brazil, West Nile virus (WNV) was first detected, in 2018, in horses with neurological disease. AIM: We report the first case of WNV infection in a horse from Ceará state and the complete genome sequence of an isolate from Espírito Santo state. Both infections occurred in 2019. METHODS: WNV was isolated from the tissues of a horse with neurological signs in Espírito Santo and sequenced by MiSeq. RESULTS: Phylogenetic analysis revealed that the isolate belongs to lineage 1a, clustering with the NY99 strain, a strain that has not circulated in the USA since 2005. CONCLUSIONS: Our findings reinforce the hypothesis that WNV has been silently circulating in Brazil for many years.

https://doi.org/10.1590/0037-8682-0687-2020 430 downloads

12.

Ecophysiological response of Astronium fraxinifolium (Anacardiaceae) in degraded and non-degraded brazilian Cerrado
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Leite, Marilaine Cristina Marques

; Araujo, Maycon Anderson

; Souza, Lucas Anjos

; Martins, Aline Redondo

; Camargos, Liliane Santos

Rodriguésia

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2021, Volume 72 elocation e00662020

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Plantas nativas do Cerrado geralmente apresentam características peculiares que permitem tolerar o estresse hídrico e nutricional. Astronium fraxinifolium, é uma das espécies arbóreas de Anacardiaceae do Cerrado brasileiro. O objetivo desta pesquisa foi caracterizar morfofisiologicamente as folhas de A. fraxinifolium, com o objetivo de reconhecer características relacionadas a aclimatação da espécie em diferentes condições de solo. Para tanto, duas populações de A. fraxinifolium foram amostradas em diferentes áreas de estudo, A1 (Solo degradado) e A2 (“Solo não degradado”). A partir dessas amostras foram quantificados compostos nitrogenados, carboidratos totais, amido, clorofila, conteúdo nutricional, densidade estomática, trocas gasosas, alocação de carbono e altura da parte aérea, comparando as áreas de estudo. Um número elevado de estômatos foi observado na superfície abaxial das folhas de A. fraxinifolium, com uma densidade estomática mais elevada ocorrendo em indivíduos de A1. Já os valores de clorofila a, b e total foram significativamente maiores em A2. O conteúdo nutricional não diferiu entre as áreas, exceto o boro, que apresenta maior concentração nas plantas de A2. É possível que a menor concentração de boro nas plantas A1 esteja relacionado a produção de clorofila. Em relação às demais análises, não houve diferenças significativas entre as áreas. Os resultados mostram que esta espécie sofre alterações na produção de clorofila, mas a fotossíntese líquida não é perturbada, sendo o baixo teor de clorofila em A1 compensado pela maior densidade estomática. Assim, essas mudanças podem ser o resultado da aclimatação dessa espécie às diferentes condições ambientais às quais está exposta.

Abstract Plants native from Cerrado generally have peculiar characteristics that allow tolerating water and nutritional stress. Astronium fraxinifolium is a Anacardiaceae tree of from Brazilian Cerrado. The aim of this research was to characterize A. fraxinifolium leaves morphophysiologically, in order to recognize characteristics related to acclimatization of the species in different soil conditions. Two populations of A. fraxinifolium were sampled in different study areas, A1 (Degraded Soil) and A2 (“Undegraded Soil”). Nitrogen compounds, total carbohydrates, chlorophyll, nutritional content, stomatal density and gas exchanges were quantified, comparing the areas. A high number of stomata was observed on the abaxial surface of A. fraxinifolium leaves, with a higher density occurring in A1 individuals. The values of chlorophyll and boron content were significantly higher in A2 plants. It’s possible that the lowest concentration of boron in A1 plants is related to chlorophyll production. Regardinf the other analysis, there weren’t significant differences between the areas. The results show that this species undergoes changes in production of chlorophyll, but liquid photosynthesis isn’t impaired, considering the low chlorophyll content in A1 being compensated by the higher stomatal density. Thus, these changes may be the result of acclimating this species to different environmental conditions to which it’s exposed.

https://doi.org/10.1590/2175-7860202172066 40 downloads

13.

The Sun also rises
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Sarinho, Emanuel

; Ribeiro, José Dirceu

; Camargos, Paulo

Jornal Brasileiro de Pneumologia

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2021, Volume 47 N. 6 elocation e20210473

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36416/1806-3756/e20210473

14.

Modeling conditional volatility by incorporating non-regular trading hours into the APARCH model
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Araújo, Breno Valente Fontes

; Camargos, Marcos Antônio de

; Pinho, Frank Magalhães de

Revista Contabilidade & Finanças

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aug 2019, Volume 30 N. 80 Pages 202 - 215

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O estudo busca avaliar como os períodos after-market e pré-abertura impactam a estimação da volatilidade condicional de um dia à frente. A volatilidade tem bastante destaque nos estudos de finanças, pois é parâmetro fundamental na precificação de derivativos, gestão de portfólios e de risco. Os resultados são relevantes para que agentes de investimentos possam refinar os modelos de previsão da volatilidade e obter melhores resultados na precificação de derivativos, na gestão de risco, na composição e otimização de carteiras. Utilizou-se o modelo asymmetric power autoregressive conditional heteroskedasticity (APARCH), incorporando o período after-market, o leilão de pré-abertura e o overnight total, para avaliar se eles carregam informações relevantes para a modelagem da volatilidade. Analisaram-se as 20 ações de empresas brasileiras listadas na Bolsa de Valores, Mercadorias e Futuros de São Paulo (BM&FBOVESPA) e pertencentes ao índice Dow Jones Brazil Titans 20 ADR Index (BR Titans 20) com ADRs (American depositary receipts) listados nas bolsas de Nova York e na Nasdaq. Os resultados foram avaliados na amostra pelo critério de informação Akaike corrigido (AICc) e pela significância estatística dos coeficientes, e fora da amostra pelos critérios raiz dos erros quadráticos médios (root mean squared error - RMSE), erro percentual médio absoluto (mean absolut percentage error - MAPE), R² da regressão de Mincer e Zarnowitz e teste de Diebold Mariano. A análise não permite afirmar o melhor modelo, pois não há unanimidade entre todas as ações. Entretanto, os períodos não regulares do pregão demonstraram incorporar informações relevantes para a maior parte das ações. Ademais, os modelos que incorporaram o período pré-abertura obtiveram, em geral, resultados superiores aos demais, demonstrando que tal período carrega informações relevantes para a previsão da volatilidade condicional.

ABSTRACT This study aims to evaluate how the after-market and pre-opening periods affect the estimation of conditional volatility one day ahead. Volatility features quite a lot in Finance studies because it is a fundamental parameter in derivatives pricing, the efficient allocation of portfolios, and risk management. The results are relevant for investment agents to be able to refine volatility forecasting models and achieve better results in derivatives pricing, risk management, and portfolio optimization. We used the asymmetric power autoregressive conditional heteroscedasticity (APARCH) model, incorporating the after-market, pre-opening, and total overnight periods to assess whether they contain important information for modeling volatility. We analyzed the 20 stocks of Brazilian companies listed on the São Paulo Stock, Commodities, and Futures Exchange (BM&FBovespa) and also belonging to the BR Titans 20 with ADRs listed on the New York Stock Exchange and the Nasdaq. The results were evaluated in-sample using the corrected Akaike information criterion (AICc) and the statistical significance of the coefficients, and out-of-sample using root mean squared error (RMSE), mean absolut percentage error (MAPE), the R² of the Mincer-Zarnowitz regression, and the Diebold Mariano test. The analysis does not enable it to be claimed which is the best model, because there is no unanimity among all the stocks; however, non-regular trading hours were shown to incorporate important information for most of the stocks. Furthermore, the models that incorporated the pre-opening period generally obtained superior results to the models that incorporated the after-market period, demonstrating that this period contains important information for forecasting conditional volatility.

https://doi.org/10.1590/1808-057x201806100 864 downloads

15.

Treatment adherence and level of control in moderate persistent asthma in children and adolescents treated with fluticasone and salmeterol,
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Jentzsch, Nulma S.

; Silva, Gabriela C.G.

; Mendes, Guilherme M.S.

; Brand, Paul L.P.

; Camargos, Paulo

Jornal de Pediatria

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feb 2019, Volume 95 N. 1 Pages 69 - 75

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: São escassos os estudos que avaliaram a relação entre a taxa de adesão à combinação de proprionato de fluticasona/xinafoato de salmeterol e o nível de controle da asma na infância. O presente estudo teve como objetivo avaliar essa relação. Métodos: Estudo prospectivo observacional com 84 participantes, de 5 a 16 anos, todos eles com asma persistente moderada que permaneceram não controlados apesar do uso de 1.000 µg/dia de dipropionato de beclometasona em partículas não extrafinas nos três meses que antecederam a admissão no estudo. Os participantes receberam prescrição de 125 µg de propionato de fluticasona e 25 µg xinafoato de salmeterol através de inalador pressurizado, duas vezes ao dia, e foram avaliados após o 2°, 4° e 6° meses de tratamento. A taxa de adesão foi obtida por meio do contador analógico de doses incorporado ao inalador. A classificação do nível de controle da asma foi baseada numa simplificação das recomendações da Global Initiative for Asthma. Resultados: As taxas de adesão aos 2, 4 e 6 meses para a asma controlada foram 87,8%, 74,9% e 62,1% e para a asma não controlada de 71,7%, 56,0% e 47,6% (p ≤ 0,03), respectivamente. A proporção de pacientes com asma controlada elevou- se para 42,9%, 67,9% e 89,3% nas três avaliações subsequentes (p ≤ 0,001). Conclusões: Taxas de adesão entre 87,8% no 2° mês e de 62,1% no 6° mês foram determinantes para o nível de controle da asma.

Abstract Objective: There is a scarcity of studies that assessed the association between adherence to combination therapy and asthma control in pediatric patients. The authors investigated the association between adherence to fluticasone propionate/salmeterol xinafoate combination-metered aerosol and the level of asthma control in children. Methods: This was a prospective observational study of 84 patients aged 5–16 years with moderate persistent asthma, who remained uncontrolled despite the use of 1000 µg/day of inhaled nonextrafine-hydrofluoric alkane-beclomethasone dipropionate in the three months prior to study enrollment. Participants were prescribed two daily doses of FP (125 µg)/salmeterol xinafoate (25 µg) combination by metered aerosol/spacer for six months. Adherence rates were assessed using the device's dose counter after the 2nd, 4th, and 6th months of follow up. Asthma control was assessed using a simplified Global Initiative for Asthma 2014 Report classification. Results: Mean adherence rates after the second, fourth, and sixth months were 87.8%, 74.9%, and 62.1% respectively, for controlled asthma, and 71.7%, 56.0%, and 47.6% respectively, for uncontrolled asthma (all p-values ≤ 0.03). The proportion of children achieving asthma control increased to 42.9%, 67.9% and 89.3% after the 2nd, 4th and 6th months of follow-up, respectively (p ≤ 0.001). Conclusion: Adherence rates between 87.8% in the 2nd month and 62.1% in the 6th month were strong determinants of asthma control.

https://doi.org/10.1016/j.jped.2017.10.008 1462 downloads

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