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RESUMO Objetivo: Descrever os resultados iniciais da linha de base de um estudo de base populacional, bem como um protocolo para avaliar o desempenho de diferentes algoritmos de aprendizado de máquina, com o objetivo de predizer a demanda de serviços de urgência e emergência em uma amostra representativa de adultos da zona urbana de Pelotas, no Sul do Brasil. Métodos: O estudo intitula-se “Emergency department use and Artificial Intelligence in PELOTAS (RS) (EAI PELOTAS)” (https://wp.ufpel.edu.br/eaipelotas/). Entre setembro e dezembro de 2021, foi realizada uma linha de base com os participantes. Está previsto um acompanhamento após 12 meses para avaliar a utilização de serviços de urgência e emergência no último ano. Em seguida, serão testados algoritmos de machine learning para predizer a utilização de serviços de urgência e emergência no período de um ano. Resultados: No total, 5.722 participantes responderam à pesquisa, a maioria do sexo feminino (66,8%), com idade média de 50,3 anos. O número médio de pessoas no domicílio foi de 2,6. A maioria da amostra tem cor da pele branca e ensino fundamental incompleto ou menos. Cerca de 30% da amostra estava com obesidade, 14% com diabetes e 39% eram hipertensos. Conclusão: O presente trabalho apresentou um protocolo descrevendo as etapas que foram e serão tomadas para a produção de um modelo capaz de prever a demanda por serviços de urgência e emergência em um ano entre moradores de Pelotas, no estado do Rio Grande do Sul.

RESUMO Objetivo: To describe the initial baseline results of a population-based study, as well as a protocol in order to evaluate the performance of different machine learning algorithms with the objective of predicting the demand for urgent and emergency services in a representative sample of adults from the urban area of Pelotas, Southern Brazil. Methods: The study is entitled “Emergency department use and Artificial Intelligence in PELOTAS (RS) (EAI PELOTAS)” (https://wp.ufpel.edu.br/eaipelotas/). Between September and December 2021, a baseline was carried out with participants. A follow-up was planned to be conducted after 12 months in order to assess the use of urgent and emergency services in the last year. Afterwards, machine learning algorithms will be tested to predict the use of urgent and emergency services over one year. Results: In total, 5,722 participants answered the survey, mostly females (66.8%), with an average age of 50.3 years. The mean number of household people was 2.6. Most of the sample has white skin color and incomplete elementary school or less. Around 30% of the sample has obesity, 14% diabetes, and 39% hypertension. Conclusion: The present paper presented a protocol describing the steps that were and will be taken to produce a model capable of predicting the demand for urgent and emergency services in one year among residents of Pelotas, in Rio Grande do Sul state.

https://doi.org/10.1590/1980-549720230021

Tetanus in a canine: clinical and therapeutic aspects
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Silva, Gabriela Pereira da

; Garcia, Cinthia

; Silva, Rúbia Schallenberger da

; Klaser, Bruno Webber

; Arenhart, Sandra

; Menin, Álvaro

; Lima, Andressa Antunes de

; Padilha, Vanessa Sasso

Ciência Animal Brasileira

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2023, Volume 24 elocation e-73825

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O tétano é uma doença grave e rara em pequenos animais, de caráter agudo e mediada pela ação da neurotoxina tetanospasmina, proveniente do bacilo Clostridium tetani. Neste relato descreve-se um caso de tétano em um canino, com ênfase em seus aspectos clínicos e terapêuticos, além da sua recuperação clínica. Foi atendido no Hospital Veterinário da Universidade de Passo Fundo, um canino, fêmea, da raça Pitbull, com cinco meses, em status epilepticus. Após a estabilização da paciente, constataram-se animal em posição de cavalete, com paralisia espástica generalizada, risus sardonicus, trismo, cauda e orelhas eretas e dificuldade em expandir o tórax. O diagnóstico presuntivo de tétano foi firmado a partir da anamnese, sinais clínicos e achados laboratoriais. O tratamento suporte estabelecido incluiu reposição hidroeletrolítica, soro antitetânico, antibioticoterapia, analgesia, fármacos miorrelaxantes e anticonvulsivantes. O manejo intensivo da paciente foi realizado com sondagem uretral e nasoesofágica, trocas de decúbito a cada duas horas e diminuição de estímulos ambientais. A fisioterapia e a acupuntura também foram utilizadas para complementar o tratamento e acelerar a recuperação. A paciente recebeu alta médica um mês após o início do tratamento, apresentando evolução satisfatória. No presente caso, o exame clínico em associação aos sinais clínicos característicos da doença, acrescidos da anamnese minuciosa foram fundamentais ao diagnóstico presuntivo de tétano. Além disso, o manejo intensivo, o tratamento medicamentoso, assim como a realização de fisioterapia e acupuntura, possibilitaram a evolução do quadro clínico à cura.

Abstract Tetanus is a serious and rare disease in small animals, of an acute nature and mediated by the action of the neurotoxin tetanospasmin, from the bacillus Clostridium tetani. This report describes a case of tetanus in a canine, with emphasis on its clinical and therapeutic aspects, in addition to its clinical recovery. A canine, female, Pitbull breed, five months old, in status epilepticus, was attended at the Veterinary Hospital of the University of Passo Fundo. After stabilizing the patient, the animal was found in a trestle position, with generalized spastic paralysis, risus sardonicus, trismus, erect tail and ears, and difficulty in expanding the thorax. The presumptive diagnosis of tetanus was established based on the anamnesis, clinical signs, and laboratory findings. The established supportive treatment included hydro electrolytic replacement, antitetanus serum, antibiotic therapy, analgesia, myorelaxant and anticonvulsant drugs. The patient's intensive management was carried out with urethral and gastroesophageal probing, changes of position every two hours, and reduction of environmental stimuli. Physiotherapy and acupuncture were also used to complement the treatment and accelerate recovery. The patient was discharged one month after the beginning of the treatment, presenting satisfactory evolution. In the present case, the clinical examination in association with the characteristic clinical signs of the disease, added to the detailed anamnesis, was essential for the presumptive diagnosis of tetanus. In addition, intensive management, drug treatment, physiotherapy, and acupuncture enabled the evolution of the clinical condition to cure.

https://doi.org/10.1590/1809-6891v24e-73825e

Emergency department use and Artificial Intelligence in Pelotas: design and baseline results
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Delpino, Felipe Mendes

; Figueiredo, Lílian Munhoz

; Costa, Ândria Krolow

; Carreno, Ioná

; Silva, Luan Nascimento da

; Flores, Alana Duarte

; Pinheiro, Milena Afonso

; Silva, Eloisa Porciúncula da

; Marques, Gabriela Ávila

; Saes, Mirelle de Oliveira

; Duro, Suele Manjourany Silva

; Facchini, Luiz Augusto

; Vissoci, João Ricardo Nickenig

; Flores, Thaynã Ramos

; Demarco, Flávio Fernando

; Blumenberg, Cauane

; Chiavegatto Filho, Alexandre Dias Porto

; Silva, Inácio Crochemore da

; Batista, Sandro Rodrigues

; Arcêncio, Ricardo Alexandre

; Nunes, Bruno Pereira

Revista Brasileira de Epidemiologia

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2023, Volume 26 elocation e230021

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1980-549720230021

Basaloid follicular hamartoma following Blaschko’s lines
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Queiroz, Gabriela Martins de

; Lopes, Tayla Cristina

; Soares, Maria Clara Dantas Valle

; Lima, Carlos Bruno Fernandes

Anais Brasileiros de Dermatologia

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nov 2022, Volume 97 N. 6 Pages 823 - 825

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.abd.2020.10.027

Negative dimension stability across clinical stages and sociodemographic characteristics in schizophrenia
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Koga, Gabriela

; Haguiara, Bernardo

; Ortiz, Bruno

; Noto, Cristiano

; Freitas, Rosana Ramos

; Elkis, Helio

; Bressan, Rodrigo

; Ziebold, Carolina

; Gadelha, Ary

Brazilian Journal of Psychiatry

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oct 2022, Volume 44 N. 5 Pages 558 - 560

Abstract: En | Text: En | PDF: En

https://doi.org/10.47626/1516-4446-2022-2570

Oral mucoceles: A Brazillian Multicenter Study of 1,901 Cases
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Miranda, Georgea Gabriela Barreto

; Chaves-Junior, Samuel de Carvalho

; Lopes, Matheus Paschoaletto

; Rocha, Talytha Barbosa da

; Colares, Débora Frota

; Ito, Fábio Augusto

; Cavalcante, Israel Leal

; Cavalcante, Roberta Barroso

; Andrade, Bruno Augusto Benevenuto de

; Nonaka, Cassiano Francisco Weege

; Alves, Pollianna Muniz

; Albuquerque-Júnior, Ricardo Luiz Cavalcanti de

; Cunha, John Lennon Silva

Brazilian Dental Journal

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oct 2022, Volume 33 N. 5 Pages 81 - 90

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A mucocele oral (MO) é a lesão mais comum das glândulas salivares menores. O presente estudo teve como objetivo relatar as características clínicas e demográficas de uma grande série de MOs e identificar possíveis variáveis preditivas associadas à taxa de recorrência dessas lesões. Foi realizado um estudo transversal descritivo retrospectivo. Foram analisados 43.754 registros de biópsias de quatro serviços de patologia no Brasil. Todos os casos diagnosticados como MOs foram revisados e dados clínicos e demográficos foram coletados. Participaram do estudo 1.002 mulheres (56,2%) e 782 homens (43,8%), com média de idade de 19,8 ± 16,4 anos (variação: 01-87 anos) e proporção de mulheres para homens de 1,3:1. O lábio inferior (n=1.160; 67,4%) e assoalho da boca (n=172; 10,0%), foram os locais mais acometidos, apresentando-se clinicamente como nódulos (n=978; 79,4%) de superfície lisa (n =428; 77,5%) e coloração normal (n=768, 46,7%). A biópsia excisional foi o tratamento na maioria dos casos (n=1.392; 78,0%). As MOs recorrentes representaram 6,2% de todos os casos diagnosticados (n = 117). As recorrências recorreram mais comumente em pacientes mais jovens (idade < 20 anos) (p < 0,0001), em lesões maiores que 2 cm de diâmetro (p < 0,0001) e naquelas localizadas na superfície ventral da língua (p = 0,0351). Além disso, as taxas de recorrência foram significativamente maiores nos casos tratados com cirurgia a laser do que aqueles com cirurgia convencional utilizando bisturi (p = 0,0005). Pacientes com mucoceles devem ser informados sobre uma possível recorrência, principalmente quando encontrados no lábio ou assoalho bucal de pacientes jovens.

Abstract Oral mucocele (OM) is the most common lesion of minor salivary glands. The present study aimed to report the clinical and demographic features of a large series of OMs and identify possible predictive variables associated with the recurrence rate of these lesions. A retrospective descriptive cross-sectional study was performed. A total of 43,754 biopsy records from four pathology services in Brazil were analyzed. All cases of OMs were reviewed, and clinical and demographic data were collected. The study comprised 1,002 females (56.2%) and 782 males (43.8%), with a mean age of 19.8±16.4 years (range: 01-87 years) and a 1.3:1 female-to-male ratio. The lower lip (n=1,160; 67.4%), and floor of the mouth (n=172; 10.0%), were the most common affected sites, presenting clinically as nodules (n=978; 79.4%) of smooth surface (n=428; 77.5%) and normal color (n=768, 46.7%). Excisional biopsy was the treatment in most cases (n=1,392; 78.0%). Recurrent OMs represented 6.2% of all diagnosed cases (n=117). OMs recurred more commonly in younger patients (aged<20 years) (p<0.0001), in lesions larger than 2 cm in diameter (p<0.0001), and in those located in the ventral tongue (p=0.0351). Also, recurrence rates were higher significantly in cases treated with laser surgery than in those with conventional surgery (p=0.0005). Patients with OMs should be carefully informed of its possible recurrence, especially when found on the ventral tongue of young patients.

https://doi.org/10.1590/0103-6440202204965

A New Approach for Histamine Functionalized Nanoparticles as Sorbent Phase for Bar Adsorptive Microextraction (BAµE) and Determination of Parabens in Water by HPLC-DAD
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Lopes, Daniela

; Morés, Lucas

; Bernardi, Gabrieli

; Campedelli, Roberta R.

; Pinheiro, Gabriela

; Souza, Bruno S. de

; Carasek, Eduardo

Journal of the Brazilian Chemical Society

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sep 2022, Volume 33 N. 9 Pages 1098 - 1105

Abstract: En | Text: En | PDF: En

In this study, for the first time, histamine-functionalized magnetic nanoparticles (HIS-MNP) were used as sorbent phase combined with bar adsorptive microextraction (BAµE) for the determination of methylparaben (MP), ethylparaben (EP), propylparaben (PP), and butylparaben (BP) in water samples by high performance liquid chromatography coupled with diode array detection (HPLC-DAD). Extraction and desorption conditions, including desorption time and solvent, ionic strength effect and extraction time, were investigated. The extractions were performed for 90 min, 30% of NaCl and sample pH 5. Desorption was carried out using 250 μL of acetonitrile:methanol (25:75 v/v) for 30 min. The limits of detection (LODs) were of 1.5 μg L-1 and limits of quantification (LOQs) were 5.0 μg L-1 for all analytes. The intra-day precision ranged from 1% for EP, PP and BP to 3% for MP, EP, PP and BP. The inter-day precision ranged from 3% for EP to 18% for BP. The relative recoveries varied from 81 to 125%, and relative standard deviations (RSD) ranged between 1 and 16%.

https://doi.org/10.21577/0103-5053.20220028

[SciELO Preprints] - ANALYSIS OF FUNCTIONAL CAPACITY AND ASSOCIATION WITH SOCIO-DEMOGRAPHIC CHARACTERISTICS, DISEASES AND HABITS OF WOMEN RESIDENTS IN PERIPHERY
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Ferreira, Bruno Holanda Miranda, Maria Luiza de Jesus Rodrigues, Graciele Massoli Marques, Bruna Gabriela

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Publication date: 2022-07-04

Abstract: En Pt Es

Objective of this study was to estimate functional capacity and analyze the association with sociodemographic characteristics, lifestyle habits, morbidity, multimorbidity and falls among elderly women living in a periphery of the city of São Paulo. A cross-sectional study of simple random sampling was carried out, whose study population consisted of 174 women (≥60 years of age) registered and a Unidade Básica de Saúde - (UBS) Jardim Rincão, city of São Paulo, Brazil, were randomly selected in the period of August to December 2015. Descriptive and inferential statistics were performed based on sociodemographic variables, life habits, chronic disease, physical activity and self-assessment of functional capacity. The results show a high prevalence of insufficient functional capacity in the population studied, 81.0%. After crude and adjusted logistic regression analysis, no statistical differences were observed in the analyzed variables pgt;0.05. Thus, the study revealed that sociodemographic variables, life habits, chronic diseases have no effect on the functional capacity of elderly women living in a periphery. Therefore, comprehensive health care actions for the elderly need to be carried out, combining incentives for research in areas of social vulnerability and actions planned to improve disabling conditions.

O objetivo deste estudo foi estimar a capacidade funcional e analisar a associação com as características sociodemográficas, hábitos de vida, morbidade, multimorbidade e quedas entre mulheres idosas residentes em uma periferia do município de São Paulo. Foi realizado um estudo transversal de amostragem aleatória simples cuja população estudada foi de 174 mulheres (≥60 anos de idade) cadastradas e uma Unidade Básica de Saúde – (UBS) Jardim Rincão do município de São Paulo foram selecionadas de maneira aleatória no período de agosto a dezembro de 2015. Foram executadas estatísticas descritivas e inferenciais a partir de variáveis sociodemográficas, hábitos de vida, doença crônica, atividade física e autoavaliação da capacidade funcional. Os resultados evidenciam elevada prevalência de capacidade funcional insuficiente na população estudada 81,0%. Após análise de regressão logística bruta e ajustada, não foram observadas diferenças estatísticas nas variáveis analisadas pgt;0,05. Assim, o estudo revelou que variáveis sociodemográficas, hábitos de vida, doenças crônicas não possuem efeito sobre a capacidade funcional de idosas residentes de uma periferia. Portanto, ações de atenção integral à saúde das idosas precisam ser efetivadas, aliando o incentivo à pesquisa em áreas de vulnerabilidade social e às ações planejadas para melhorar as condições incapacitantes.

El objetivo de este estudio fue estimar la capacidad funcional y analizar la asociación con características sociodemográficas, hábitos de vida, morbilidad, multimorbilidad y caídas entre ancianas residentes en una periferia de la ciudad de São Paulo. Se realizó un estudio transversal de muestreo aleatorio simple, cuya población de estudio estuvo constituida por 174 mujeres (≥60 años) registradas y una Unidade Básica de Saúde - (UBS) Jardim Rincão, ciudad de São Paulo, Brasil, fueron seleccionadas aleatoriamente seleccionados en el período de agosto a diciembre de 2015. Se realizó estadística descriptiva e inferencial a partir de variables sociodemográficas, hábitos de vida, enfermedad crónica, actividad física y autoevaluación de la capacidad funcional. Los resultados muestran una alta prevalencia de capacidad funcional insuficiente en la población estudiada, 81,0%. Después del análisis de regresión logística cruda y ajustada, no se observaron diferencias estadísticas en las variables analizadas pgt;0,05. Así, el estudio reveló que las variables sociodemográficas, los hábitos de vida, las enfermedades crónicas no tienen efecto sobre la capacidad funcional de las ancianas que viven en la periferia. Por lo tanto, es necesario realizar acciones de atención integral a la salud de las personas mayores, combinando incentivos a la investigación en áreas de vulnerabilidad social y acciones planificadas para mejorar las condiciones de discapacidad.

https://doi.org/10.1590/SciELOPreprints.4385

Estimuladores de Guanilato Ciclase Solúvel (Riociguate) na Hipertensão Pulmonar: Dados da Prática Clínica Real em 3 Anos de Acompanhamento
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Spilimbergo, Fernanda Brum

; Assmann, Taís Silveira

; Bellon, Marcelo

; Hoscheidt, Laís Machado

; Caurio, Cássia Ferreira Braz

; Puchalski, Márcia

; Hochhegger, Bruno

; Roncato, Gabriela

; Meyer, Gisela Martina Bohns

Arquivos Brasileiros de Cardiologia

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jun 2022, Volume 118 N. 6 Pages 1059 - 1066

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento A hipertensão pulmonar (HP) é uma doença rara e complexa com prognóstico ruim, que exige tratamento pela vida toda. Objetivo Descrever dados de 3 anos de acompanhamento da vida real sobre o tratamento com estimuladores de guanilato ciclase solúvel (Riociguate) de pacientes com HP, medindo parâmetros atuais de avaliação de risco. Métodos Coletamos dados clínicos e epidemiológicos retrospectivamente de pacientes com HP do grupo 1 (hipertensão arterial pulmonar) e do grupo 4 (HP tromboembólica crônica). Parâmetros não invasivos e invasivos correspondentes à avaliação de risco foram analisados na linha de base e no acompanhamento. Foram realizadas análises estatísticas usando o software SPSS 18.0, e os p-valores <0,050 foram considerados estatisticamente significativos. Resultados No total, 41 pacientes tratados com riociguate foram incluídos no estudo. Entre eles, 31 já concluíram 3 anos de tratamento e foram selecionados para a seguinte análise. Na linha de base, 70,7% dos pacientes estavam nas classes funcionais III ou IV da OMS. Depois de 3 anos de tratamento, a classe funcional da OMS melhorou significativamente em todos os pacientes. Além disso, a mediana do teste de caminhada de 6 minutos (TC6M) aumentou significativamente de 394 ± 91 m na linha de base para 458 ± 100 m após 3 anos de acompanhamento (p= 0,014). O índice de sobrevida após três anos foi de 96,7%. Conclusão Em nossa coorte de vida real, a maioria dos pacientes com HP tratados com riociguate demonstraram parâmetros de risco estáveis ou melhores, especialmente no TC6M, aos 3 anos de acompanhamento.

Abstract Background Pulmonary hypertension (PH) is a rare and complex disease with poor prognosis, which requires lifelong treatment. Objective To describe 3-year follow-up real-life data on treatment with soluble guanylate cyclase stimulators (Riociguat) of patients with PH, measuring current risk assessment parameters. Methods This study retrospectively collected clinical and epidemiological data of patients with PH of group 1 (pulmonary arterial hypertension) and group 4 (chronic thromboembolic PH). Non-invasive and invasive parameters corresponding to the risk assessment were analyzed at baseline and follow-up. Statistical analyses were performed using the SPSS 18.0 software, and p-values < 0.050 were considered statistically significant. Results In total, 41 patients receiving riociguat were included in the study. Of them, 31 had already completed 3 years of treatment and were selected for the following analysis. At baseline, 70.7% of patients were in WHO functional class III or IV. After 3 years of treatment, the WHO functional class significantly improved in all patients. In addition, the median of the 6-minute walk test (6MWT) significantly increased from 394 ± 91 m at baseline to 458 ± 100 m after 3 years of follow-up (p= 0.014). The three-year survival rate was 96.7%. Conclusion In our real-life cohort, most patients with PH treated with riociguat showed stable or improved risk parameters, especially in the 6MWT, at 3 years of follow-up.

https://doi.org/10.36660/abc.20210492

10.

Síndrome do T3 baixo como fator prognóstico em pacientes na unidade de terapia intensiva: estudo de coorte observacional
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Pontes, Carla Daniele Nascimento

; Rocha, Juliane Lúcia Gomes da

; Medeiros, Janaina Maria Rodrigues

; Santos, Bruno Fernando Barros dos

; Silva, Paulo Henrique Monteiro da

; Medeiros, Janine Maria Rodrigues

; Costa, Gabriela Góes

; Silva, Isabella Mesquita Sfair

; Gomes, Daniel Libonati

; Santos, Flávia Marques

; Libonati, Rosana Maria Feio

Revista Brasileira de Terapia Intensiva

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jun 2022, Volume 34 N. 2 Pages 262 - 271

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliar a síndrome do doente eutireóideo como fator prognóstico em pacientes na unidade de terapia intensiva, detectar fatores que possam influenciar a mortalidade e desenvolver uma equação para calcular a probabilidade de morte. Métodos: Este foi um estudo de coorte longitudinal, observacional e não concorrente realizado na unidade de terapia intensiva da Fundação Santa Casa de Misericórdia do Pará. Realizou-se coleta de 20mL de sangue em 100 adultos sem endocrinopatia previamente documentada para a dosagem do hormônio estimulante da tireoide, da tetraiodotironina livre, da tri-iodotironina livre e da tri-iodotironina reversa. Resultados: A maioria dos pacientes era do sexo feminino, com idades entre 20 e 29 anos. A maioria dos pacientes que morreram era mais velha (idade mediana de 48 anos), e 97,5% deles possuíam a síndrome do doente eutireóideo. A síndrome do doente eutireóideo esteve relacionada à morte, às comorbidades, à idade e ao tempo de internação (mediana de 7,5 dias) na unidade de terapia intensiva. A baixa dosagem de hormônio estimulante da tireoide estava associada à morte. Os pacientes com dosagem da tri-iodotironina livre menor que 2,9pg/mL tinham maior probabilidade de morrer e, naqueles que morreram, a dosagem de tri-iodotironina reversa era maior que 0,2ng/mL. A tri-iodotironina livre apresentou maior sensibilidade e acurácia, e a tri-iodotironina reversa teve maior especificidade para prever a mortalidade. Com base nos resultados e pontos de corte, desenvolveu-se uma fórmula de regressão logística múltipla para calcular a probabilidade de morte. Conclusão: Sugere-se verificar oportunamente a dosagem da triiodotironina livre e reversa em pacientes graves e aplicar a equação proposta.

ABSTRACT Objective: To assess euthyroid sick syndrome as a prognostic factor in patients in the intensive care unit; to detect factors that may affect mortality; and to develop an equation to calculate death probability. Methods: This was a longitudinal, observational, nonconcurrent cohort study developed in the intensive care unit of Fundação Santa Casa de Misericórdia do Pará. One hundred adults with no prior documented endocrinopathy were submitted to a 20mL blood sample collection for the measurement of thyroid stimulating hormone, free tetraiodothyronine, free triiodothyronine and reverse triiodothyronine. Results: Most patients were female, aged 20 to 29 years. Most patients who died were older (median age of 48 years), and euthyroid sick syndrome was present in 97.5% of them. Euthyroid sick syndrome was related to death, comorbidities, age and length of stay in the intensive care unit (median of 7.5 days). There was an association between lower thyroid stimulating hormone and death. Patients with free triiodothyronine levels below 2.9pg/mL were more likely to die; reverse triiodothyronine rates were above 0.2ng/mL in those who died. Free triiodothyronine had greater sensitivity and accuracy, and reverse triiodothyronine had greater specificity to predict mortality. Based on the results and cutoff points, a multiple logistic regression formula was developed to calculate the probability of death. Conclusion: The main limitation of this study is the fact that it was conducted in a reference hospital for maternal and child care; therefore, there was a greater number of female patients and, consequently, a sampling bias existed. However, opportune measurement of free and reverse triiodothyronine levels in critical patients and application of the proposed equation are suggested.

https://doi.org/10.5935/0103-507x.20220024-pt

11.

Effective recommendations towards healthy routines to preserve mental health during the COVID-19 pandemic
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Pilz, Luísa K.

; Couto Pereira, Natividade S.

; Francisco, Ana Paula

; Carissimi, Alicia

; Constantino, Débora B.

; Caus, Letícia B.

; Abreu, Ana Carolina O.

; Amando, Guilherme R.

; Bonatto, Fernanda S.

; Carvalho, Paula V.V.

; Cipolla-Neto, José

; Harb, Ana

; Lazzarotto, Gabriela

; Marafiga, Joseane Righes

; Minuzzi, Luciano

; Montagner, Francisco

; Nishino, Fernanda A.

; Oliveira, Melissa A.B.

; dos Santos, Bruno G.T.

; Steibel, Eduardo G.

; Tavares, Patrice S.

; Tonon, André C.

; Xavier, Nicóli B.

; Zanona, Querusche Klippel

; Amaral, Fernanda G.

; Calcagnotto, Maria Elisa

; Frey, Benicio N.

; Hidalgo, Maria Paz

; Idiart, Marco

; Russomano, Thais

Brazilian Journal of Psychiatry

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apr 2022, Volume 44 N. 2 Pages 136 - 146

Abstract: En | Text: En | PDF: En

Objective: To assess the adherence to a set of evidence-based recommendations to support mental health during the coronavirus disease 2019 (COVID-19) pandemic and its association with depressive and anxiety symptoms. Methods: A team of health workers and researchers prepared the recommendations, formatted into three volumes (1: COVID-19 prevention; 2: Healthy habits; 3: Biological clock and sleep). Participants were randomized to receive only Volume 1 (control), Volumes 1 and 2, Volumes 1 and 3, or all volumes. We used a convenience sample of Portuguese-speaking participants over age 18 years. An online survey consisting of sociodemographic and behavioral questionnaires and mental health instruments (Patient Health Questionnaire-9 [PHQ-9] and Generalized Anxiety Disorder-7 [GAD-7]) was administered. At 14 and 28 days later, participants were invited to complete follow-up surveys, which also included questions regarding adherence to the recommendations. A total of 409 participants completed the study – mostly young adult women holding university degrees. Results: The set of recommendations contained in Volumes 2 and 3 was effective in protecting mental health, as suggested by significant associations of adherence with PHQ-9 and GAD-7 scores (reflecting anxiety and depression symptoms, respectively). Conclusion: The recommendations developed in this study could be useful to prevent negative mental health effects in the context of the pandemic and beyond.

https://doi.org/10.1590/1516-4446-2021-2109

12.

Extracts of the Native Brazilian Tree Garcinia gardneriana Inhibit Urediniospore Germination of Coffee Leaf Rust Fungus
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Silva, Ueveton P. da

; Ferreira, Bruno W

; Sousa, Bianca L. de

; Furlani, Gabriela M

; Barreto, Robert W

; Agrizzi, Ana Paula

; Leite, João Paulo V

; Santos, Marcelo H. dos

; Varejão, Eduardo V. V

Journal of the Brazilian Chemical Society

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mar 2022, Volume 33 N. 3 Pages 217 - 226

Abstract: En | Text: En | PDF: En

The fungal Hemileia vastatrix is the causal agent of coffee leaf rust, one of the worst and devastating disease in coffee cultures worldwide. As a result of our research on natural products for the development of novel agrochemicals, we found that the hexane extract from leaves of the Brazilian medicinal plant Garcinia gardneriana, at 500 μg mL-1, inhibited in 98% the germination of H. vastatrix urediniospores. This extract showed no phytotoxicity when tested for seed germination and seedling growth inhibitory activity using sensible plant species. Also, the hexane extract from leaves was tested for anti-acetylcholinesterase activity, which constitutes a mechanism of action of major commercial insecticides used in agriculture, and showed low activity even at concentrations about two times higher than the half maximal inhibitory concentration (IC50) found in the antifungal assays. Gas chromatography-mass spectrometry (GC-MS) analysis showed that the hexane extract is constituted mainly by the pentacyclic triterpene lupeol, together with a series of sesquiterpenes as minor components. This is the first report on the investigation of antifungal, phytotoxic and acetylcholinesterase activities of extracts from leaves of G. gardneriana. These findings indicate that G. gardneriana may constitute a promising source of natural products for controlling the coffee leaf rust fungus.

https://doi.org/10.21577/0103-5053.20210139

13.

Machine Learning na Medicina: Revisão e Aplicabilidade
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Paixão, Gabriela Miana de Mattos

; Santos, Bruno Campos

; Araujo, Rodrigo Martins de

; Ribeiro, Manoel Horta

; Moraes, Jermana Lopes de

; Ribeiro, Antonio L.

Arquivos Brasileiros de Cardiologia

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jan 2022, Volume 118 N. 1 Pages 95 - 102

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20200596

14.

Effective recommendations towards healthy routines to preserve mental health during the COVID-19 pandemic
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Pilz, Luísa K.

; Couto Pereira, Natividade S.

; Francisco, Ana Paula

; Carissimi, Alicia

; Constantino, Débora B.

; Caus, Letícia B.

; Abreu, Ana Carolina O.

; Amando, Guilherme R.

; Bonatto, Fernanda S.

; Carvalho, Paula V.V.

; Cipolla-Neto, José

; Harb, Ana

; Lazzarotto, Gabriela

; Marafiga, Joseane Righes

; Minuzzi, Luciano

; Montagner, Francisco

; Nishino, Fernanda A.

; Oliveira, Melissa A.B.

; dos Santos, Bruno G.T.

; Steibel, Eduardo G.

; Tavares, Patrice S.

; Tonon, André C.

; Xavier, Nicóli B.

; Zanona, Querusche Klippel

; Amaral, Fernanda G.

; Calcagnotto, Maria Elisa

; Frey, Benicio N.

; Hidalgo, Maria Paz

; Idiart, Marco

; Russomano, Thais

Brazilian Journal of Psychiatry

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2022, N. ahead

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1516-4446-2021-2109

15.

Estimuladores de Guanilato Ciclase Solúvel (Riociguate) na Hipertensão Pulmonar: Dados da Prática Clínica Real em 3 Anos de Acompanhamento
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Spilimbergo, Fernanda Brum

; Assmann, Taís Silveira

; Bellon, Marcelo

; Hoscheidt, Laís Machado

; Caurio, Cássia Ferreira Braz

; Puchalski, Márcia

; Hochhegger, Bruno

; Roncato, Gabriela

; Meyer, Gisela Martina Bohns

Arquivos Brasileiros de Cardiologia

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2022, N. ahead

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210492

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