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How do our Dialysis Patients Die?
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Farinha, Ana

; Mendes, Beatriz

; Mateus, Ana

; Branco, Ana

; Outerelo, Cristina

; Buinho, Francisco

; Neves, Marta

; Ponce, Pedro

Portuguese Journal of Nephrology & Hypertension

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mar 2023, Volume 37 N. 1 Pages 11 - 16

Abstract: En | Text: En | PDF: En

ABSTRACT Introduction: Elderly patients are the most frequent patients admitted to dialysis units. Relatively little is known about standards on endof-life (EOL) care among dialysis patients. From international literature, these patients are exposed to more aggressive treatments at EOL than patients with cancer or other chronic diseases and palliative referral is infrequent. This study aims to describe some end-of-life (EOL) practices in patients undergoing hemodialysis in NephroCare clinics in several cities in Portugal. Material and Methods: We designed a prospective, multicenter, observational, cross-sectional study conducted between October 1st, 2020 and September 30th, 2021 in six hemodialysis clinics including 1265 patients (pts). Results: During the year in analysis, 158 pts died (12.4%). Mean age was 76 years (25% of pts were older than 85 years) and dialysis vintage was 84 (2-963) months. Regarding comorbidities, 50% were diabetic, 40% had congestive heart failure, 25% had cancer and 17% had dementia. Mean age-adapted Charlson index was 13 ± 3. For 82 pts (51.9%), nephrologists would not be surprised if they died in the next 6 months. Seventy-three had hospital admissions in the previous three months. Four pts withdrew dialysis. Of those who died, only two had advance care directives, 18 had an opioid prescription in the last month of life and 17 were referred to palliative intervention mostly because of oncologic disorders. Seventy four percent of these pts died at the hospital and 23% died at home/nursing home. Not a single patient died under hospice care. Conclusion: Most of our patients commonly die in hospital, undergo invasive procedures, spend much of their remaining life fulfilling a demanding dialysis schedule and are admitted to the hospital wards without formal palliative intervention or discussion of goals of care, even when death is an expected outcome.

https://doi.org/10.32932/pjnh.2023.02.220

Cancro durante a gravidez: visão global sobre o diagnóstico, tratamento e conduta obstétrica
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Jorge, Inês

; Amaral, Njila

; Baptista, Carlota

; Branco, Francisco

Acta Obstétrica e Ginecológica Portuguesa

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mar 2023, Volume 17 N. 1 Pages 46 - 58

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract We present evidence regarding the safety of diagnostic/staging methods and therapeutic options, as well as regarding obstetric risks and obstetric management in women with cancer during pregnancy. Most diagnostic methods can be used with relative safety. It is generally agreed that surgery is safe during pregnancy and chemotherapy should be avoided in the first trimester. In order to decide the type of therapy, the benefits for the mother and the risks for the fetus must be balanced, taking into account the gestational age, the physiological changes of pregnancy and the limited evidence regarding the safety of most drugs in pregnancy.

Resumo Apresenta-se evidência relativa à segurança dos métodos de diagnóstico/estadiamento e terapêutica, bem como relativamente aos riscos obstétricos e à conduta obstétrica em mulheres com cancro na gravidez. A maioria dos métodos de diagnóstico/estadiamento pode ser usada com relativa segurança. É consensual que a cirurgia é segura durante a gravidez e a quimioterapia deve ser evitada no primeiro trimestre. Para uma decisão terapêutica devem contrabalancear-se os benefícios para a mãe e os riscos para o feto, tendo em conta a idade gestacional, as alterações fisiológicas da gravidez e a evidência limitada relativamente à segurança da maioria dos fármacos na gravidez.

Brazilian consensus for diagnosis, management and treatment of hereditary transthyretin amyloidosis with peripheral neuropathy: second edition
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Pinto, Marcus Vinicius

; França Jr, Marcondes Cavalcante

; Gonçalves, Marcus Vinicius Magno

; Machado-Costa, Marcela Câmara

; Freitas, Marcos Raimundo Gomes de

; Gondim, Francisco de Assis Aquino

; Marrone, Carlo Domenico

; Martinez, Alberto Rolim Muro

; Moreira, Carolina Lavigne

; Nascimento, Osvaldo J. M.

; Covaleski, Anna Paula Paranhos

; Oliveira, Acary Souza Bulle de

; Pupe, Camila Castelo Branco

; Rodrigues, Marcia Maria Jardim

; Rotta, Francisco Tellechea

; Scola, Rosana Herminia

; Marques Jr, Wilson

; Waddington-Cruz, Márcia

Arquivos de Neuro-Psiquiatria

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mar 2023, Volume 81 N. 3 Pages 308 - 321

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Hereditary transthyretin amyloidosis with peripheral neuropathy (ATTRv-PN) is an autosomal dominant inherited sensorimotor and autonomic polyneuropathy with over 130 pathogenic variants identified in the TTR gene. Hereditary transthyretin amyloidosis with peripheral neuropathy is a disabling, progressive and life-threatening genetic condition that leads to death in ~ 10 years if untreated. The prospects for ATTRv-PN have changed in the last decades, as it has become a treatable neuropathy. In addition to liver transplantation, initiated in 1990, there are now at least 3 drugs approved in many countries, including Brazil, and many more are being developed. The first Brazilian consensus on ATTRv-PN was held in the city of Fortaleza, Brazil, in June 2017. Given the new advances in the area over the last 5 years, the Peripheral Neuropathy Scientific Department of the Brazilian Academy of Neurology organized a second edition of the consensus. Each panelist was responsible for reviewing the literature and updating a section of the previous paper. Thereafter, the 18 panelists got together virtually after careful review of the draft, discussed each section of the text, and reached a consensus for the final version of the manuscript.

Resumo Polineuropatia amiloidótica familiar associada a transtirretina (ATTRv-PN) é uma polineuropatia sensitivo-motora e autonômica hereditária autossômica dominante com mais de 130 variantes patogênicas já identificadas no gene TTR. A ATTRv-PN é uma condição genética debilitante, progressiva e que ameaça a vida, levando à morte em ~ 10 anos se não for tratada. Nas últimas décadas, a ATTRv-PN se tornou uma neuropatia tratável. Além do transplante de fígado, iniciado em 1990, temos agora 3 medicamentos modificadores de doença aprovados em muitos países, incluindo o Brasil, e muitas outras medicações estão em desenvolvimento. O primeiro consenso brasileiro em ATTRv-PN foi realizado em Fortaleza em junho de 2017. Devido aos novos avanços nesta área nos últimos 5 anos, o Departamento Científico de Neuropatias Periféricas da Academia Brasileira de Neurologia organizou uma segunda edição do consenso. Cada panelista ficou responsável por rever a literatura e atualizar uma parte do manuscrito. Finalmente, os 18 panelistas se reuniram virtualmente após revisão da primeira versão, discutiram cada parte do artigo e chegaram a um consenso sobre a versão final do manuscrito.

https://doi.org/10.1055/s-0043-1764412

LAPAROSCOPIC AND LAPAROTOMY BARIATRIC SURGERY IN A PUBLIC HOSPITAL IN BRAZIL: ARE THERE DIFFERENCES IN COSTS AND COMPLICATIONS?
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Schiel, Wagner Augusto

; Peppe Neto, Antônio de Pádua

; Weiss, André Gubert

; Cortiano, Luís Gustavo Guides

; Branco Filho, Alcides José

; Almeida, Francisco Emanuel

; Rocco, Mateus

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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2023, Volume 36 elocation e1739

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT BACKGROUND: Despite its increasing popularity, laparoscopy is not the option for bariatric surgeries performed in the Brazilian public health system. AIMS: To compare laparotomy and laparoscopic access in bariatric surgery, considering aspects such as morbidity, mortality, costs, and length of stay. METHODS: The study included 80 patients who were randomly assigned to perform a Roux-en-Y gastric bypass. They were equally divided in two groups, laparoscopic and laparotomy. The results obtained in the postoperative period were evaluated and compared according to the Ministry of Health protocol, and later, in their outpatient returns. RESULTS: The surgical time was similar in both groups (p=0.240). The costs of laparoscopic surgery proved to be higher, mainly due to staplers and staples. The patients included in the laparotomy group presented higher rates of severe complications, such as incisional hernia (p<0.001). Costs related to social security and management of postoperative complications were higher in the open surgery group (R$ 1,876.00 vs R$ 34,268.91). CONCLUSIONS: The costs related to social security and treatment of complications were substantially lower in laparoscopic access when compared to laparotomy. However, considering the operative procedure itself, the laparotomy remained cheaper. Finally, the length of stay, the rate of complications, and return to labor had more favorable results in the laparoscopic route.

RESUMO RACIONAL: Apesar de sua crescente popularidade, a laparoscopia não é a via de acesso em cirurgias bariátricas realizadas no sistema público de saúde brasileiro. OBJETIVOS: Comparar os acessos laparoscópico e laparotômico em cirurgia bariátrica, considerando aspectos como morbidade, mortalidade, custos e tempo de hospitalização. MÉTODOS: Foram incluídos 80 pacientes candidatos a by-pass gástrico em Y-de-Roux, aleatoriamente divididos em dois grupos, de acordo com a via de acesso. Os resultados obtidos no período pós-operatório foram avaliados e comparados de acordo com o protocolo do Ministério da Saúde, e posteriormente, em seus retornos ambulatoriais. RESULTADOS: O tempo cirúrgico foi semelhante em ambos os grupos (p=0.240). Os custos da cirurgia laparoscópica foram maiores, principalmente devido aos grampeadores e cargas. Contudo, os pacientes designados à via aberta apresentaram maior índice de complicações graves, como hérnia incisional (p<0.001). Desta forma, os custos com o tratamento das complicações e com o seguro social foram maiores neste grupo (R$ 1,876.00 vs R$ 34,268.91). CONCLUSÃO: Os gastos relacionados ao seguro social e ao tratamento de complicações foram substancialmente menores na cirurgia laparoscópica quando comparada à cirurgia aberta. Entretanto, considerando o procedimento operatório em si, a via aberta foi a mais acessível financeiramente. Por fim, o tempo de hospitalização, a taxa de complicações e o tempo de retorno ao trabalho tiveram resultados mais favoráveis na via laparoscópica.

https://doi.org/10.1590/0102-672020230021e1739

BRS 438: Sugary cassava cultivar for diversification of the use of storage roots
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Vieira, Eduardo Alano

; Fialho, Josefino de Freitas

; Carvalho, Luiz Joaquim Castelo Branco

; Gonçalves, Silvia Belem

; Fernandes, Francisco Duarte

; Oliveira, Charles Martins de

; Antonini, Jorge Cesar dos Anjos

; Rinaldi, Maria Madalena

; Malaquias, Juaci Vitoria

Crop Breeding and Applied Biotechnology

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2023, Volume 23 N. 4 elocation e46122342

Abstract: En | Text: En | PDF: En

Abstract The sugary cassava cultivar BRS 438 has high roots yield (with expressive concentration of free sugars), adaptation to mechanized planting, and moderate resistance to bacterial diseases. These characteristics make it an option for production of sugars, alcohol, and animal feed (additive in forage grass silage), among other possibilities.

https://doi.org/10.1590/1984-70332023v23n4c37

Capra hircus outliers markers in Brazil: Searching for genomic regions under the action of natural selection
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Diniz Sobrinho, Francisco de A.

; Moura, Jeane de O.

; Bajay, Miklos M.

; Branco, Leonardo Castelo

; Bezerra, Roosevelt D.S.

; Araújo, Adriana M. de

Genetics and Molecular Biology

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2023, Volume 46 N. 3 elocation e20230084

Abstract: En | Text: En | PDF: En

Abstract Identifying genome regions subject to selection in local breeds of Brazil is an opportunity to elucidate the C. hircus genome plasticity, flowing the colonization history of the country. Using SNP Bead Chip Illumina 50K genotyping of Brazilian Anglo-Nubian (standardized breed) and Marota (local endangered population from the semiarid area of Brazil) to show outliers loci in genome regions subject to selection. After applying data quality control, 45,600 SNPs were included in this investigation. Principal component analysis (PCAdapt) and FDIST2 analysis signalized 14 genomic regions more affected by selection in the Brazilian dry zone environment. The genome study signalized regions that are close to the sequences of genes related to growth and embryonic skeletal development (FGF12, AMPD2, OSTN). In addition, flagged regions close to the genes UTSB2 and SLC5A2 contribute to research on functional adaptation with low water needs and poor nutritive diet to survive. Both genes encode proteins that act on osmotic pathways and avoid cell flooding on stress cell responses. Further studies on the genetic role and involvement of these outliers’ genomic regions, building a robust conceptual high-resolution map of natural selection drives, help to achieve hardiness candidate genes linked to the evolutionary history of Capra hircus in the semiarid area of Brazil.

https://doi.org/10.1590/1678-4685-gmb-2023-0084

“I’m gonna lose my strength, I’m gonna seize and die, And all that Jazz”! Neurological diseases in jazz legends
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Germiniani, Francisco Manoel Branco

; Camargo, Carlos Henrique Ferreira

; Coutinho, Léo

; Teive, Hélio Afonso Ghizoni

Arquivos de Neuro-Psiquiatria

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apr 2022, Volume 80 N. 4 Pages 444 - 447

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Embora o jazz seja um estilo musical que prima pela improvisação e pelo virtuosismo, não é isento de drama e tragédia, e as biografias dos músicos de jazz e a sua morte estão repletas de dificuldades sinistras e terríveis. Alguns desenvolveriam doenças crônicas e fatais. São brevemente discutidas as doenças neurológicas que afligiram os seguintes seis compositores e músicos, todos eles considerados lendas do jazz: Charles Mingus, diagnosticado com esclerose lateral amiotrófica; Lester Young e Charlie Parker, ambos com neurosífilis; Thelonius Monk, que teve uma possível demência frontotemporal; George Gershwin, que morreu em decorrência de glioma cerebral; e Cole Porter, que desenvolveu dor de membro fantasma após uma amputação. A associação do estilo de vida com o abuso de drogas, particularmente álcool e heroína, além de promiscuidade sexual, contribuiu para o desenvolvimento de uma série de doenças, por exemplo, a sífilis. Também descrevemos algumas fatalidades, como doenças neurodegenerativas e glioma cerebral.

ABSTRACT Even though jazz is a musical style that excels in improvisation and virtuosity, it is not without its share of anecdotes, drama, and downright tragedy, and the biographies of jazz musicians and their demise are fraught with ominous and dire straits. Unsurprisingly, some would develop chronic and fatal diseases. The neurological diseases that afflicted the following six composers and musicians, all of whom are considered jazz legends, are briefly discussed: Charles Mingus, diagnosed with amyotrophic lateral sclerosis; Lester Young and Charlie Parker, both diagnosed with neurosyphilis; Thelonius Monk, who had possible frontotemporal dementia; George Gershwin, who died as a result of brain glioma; and Cole Porter, who developed phantom limb pain following an amputation. The association of lifestyles, with drug abuse, particularly alcohol and heroin, in addition to great sexual promiscuity factors contributed to the development of a series of diseases such as syphilis. In addition, we also described some fatalities such as neurodegenerative diseases and cerebral glioma.

https://doi.org/10.1590/0004-282x-anp-2021-0067

Phenotype-Genotype Correlation in Colorectal Cancer: A Real-Life Study
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Frias-Gomes, Catarina

; Sousa, Ana Carla

; Rolim, Inês

; Henriques, Ana Raquel

; Branco, Francisco

; Janeiro, André

; Malveiro, Sara

; Dário, Ana Rita

; Oliveira, Maria Helena

; Borralho, Paula

; Teixeira, José Alberto

; Faria, Ana

; Maio, Rui

; Fonseca, Isabel

; Cravo, Marília

GE-Portuguese Journal of Gastroenterology

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feb 2022, Volume 29 N. 1 Pages 13 - 21

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background and Aims: Colorectal cancer (CRC) is a heterogeneous disease with distinctive genetic pathways, such as chromosomal instability, microsatellite instability and methylator pathway. Our aim was to correlate clinical and genetic characteristics of CRC patients in order to understand clinical implications of tumour genotype. Methods: Single-institution retrospective cohort of patients who underwent curative surgery for CRC, from 2012 to 2014. RAS and BRAF mutations were evaluated with the real-time PCR technique Idylla®. Mismatch repair deficiency (dMMR) was characterized by absence of MLH1, MSH6, MSH2 and/or PMS2 expression, evaluated by tissue microarrays. Overall survival (OS) and disease-free survival (DFS) were assessed using survival analysis. Results: Overall, 242 patients were included (males 57.4%, age 69.3 ± 12.9 years; median follow-up 49 months). RAS-mutated tumours were associated with reduced DFS (p = 0.02) and OS (p = 0.045) in stage I-III CRC. BRAF-mutated tumours were more predominant in females and in the right colon, similarly to dMMR tumours. BRAF status did not influence OS (4 years)/DFS (3.5 years) in stage I-III disease. However, after relapse, length of survival was 3.5 months in BRAF-mutated tumours in contrast to 18.6 months in BRAF wild-type tumours (p = NS). No germline mutations in mismatch repair genes were so far identified in the patients with dMMR tumours. Molecular phenotype (RAS, BRAF and MMR) did not influence OS in metastatic patients. Our small sample size may be a limitation of the study. Conclusion: In our cohort, RAS-mutated tumours were associated with worse DFS and OS in early-stage CRC, whereas the remaining molecular variables had no prognostic influence.

Resumo Introdução: O cancro colo-rectal (CCR) é uma doença heterogénea, com vias genéticas distintas, nomeadamente instabilidade cromossómica, instabilidade de microssatélites e via metiladora. O nosso objetivo foi correlacionar as características clínicas e genéticas dos doentes com CCR e, deste modo, conhecer as implicações na prática clínica do genótipo tumoral. Métodos: Estudo de coorte retrospectivo unicêntrico de doentes diagnosticados com CCR e submetidos a cirurgia com intuito curativo, entre 2012 e 2014. As mutações RAS e BRAF foram avaliadas pela técnica de real time PCR Idylla®. A deficiência de mismatch repair(MMR) foi avaliada pela técnica de tissue microarrayse definida pela ausência de expressão de MLH1, MSH6, MSH2 e/ou PMS2. A sobrevivência global (SG) e a sobrevivência livre de doença (SLD) foram avaliadas por análise de sobrevivência. Resultados: No total, foram incluídos 242 doentes (homens 57.4%, idade 69.3 ± 12.9 anos, mediana de seguimento de 49 meses). Os tumores RAS-mutados associaram-se a menor SLD (p = 0.02) e SG (p = 0.045) em doentes com CCR estadio I-III. Os tumores BRAF-mutados foram mais frequentes em mulheres e nos tumores do cólon direito, assim como os tumores com deficiência para MMR. O status BRAF não influenciou a SG (4 anos)/SLD (3.5 anos) nos estadio I-III. Contudo, após a recidiva, o tempo de sobrevivência foi de 3.5 meses nos tumores BRAF-mutados, em comparação com 18.6 meses nos tumores sem esta mutação (p = NS). Não se identificaram mutações germinativas nos genes de mismatch repair nos doentes com tumores deficientes para estas proteinas (dMMR). O perfil molecular (RAS, BRAF e MMR)não influenciou a sobrevivência global dos doentes com metástases ao diagnóstico. O tamanho da amostra pode ser uma limitação do estudo. Conclusão: Na nossa coorte, os tumores RAS-mutados associaram-se a pior SLD e SG nos estádios precoces de CCR. Os restantes marcadores moleculares não influenciaram o prognóstico dos doentes.

https://doi.org/10.1159/000516009 24 downloads

Flora and physiognomy of Caatinga vegetation over crystalline bedrock in the northern Caatinga domain, Brazil
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Souza, Elnatan Bezerra de

; Nepomuceno, Francisco Álvaro Almeida

; Santos, Francisco Diego Sousa

; Araújo, Francisco Fernandes de

; Nepomuceno, Izaíra Vasconcelos

; Paula, Alexandre Souza de

; Amorim, Vivian Oliveira

; Branco, Mário Sérgio Duarte

; Rabelo, Samuel Trajano

; Pinto, David Mendes Macelli

; Nascimento, João Batista Silva do

; Moro, Marcelo Freire

Rodriguésia

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2022, Volume 73 elocation e01252021

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O bioma das Florestas e Arbustais Tropicais Sazonalmente Secos tem na Caatinga sua mais extensa área, possuindo elevada diversidade florística e ambiental. Caracterizamos a composição florística e a fisionomia da vegetação no Refúgio da Vida Silvestre Pedra da Andorinha (RPA), área de conservação no noroeste do estado do Ceará, Brasil. Realizamos coletas botânicas entre março de 2015 e maio de 2021, aplicando os métodos tradicionais de coleta e herborização. Todo o material foi depositado no herbário HUVA. A fitossociologia foi feita em cinco parcelas de 50 x 50 m (1,25 ha), onde os indivíduos lenhosos com diâmetro ao nível do solo ³ a 3 cm foram inventariados. Avaliamos os parâmetros fitossociológicos de estrutura da vegetação e sua diversidade florística. Identificamos 266 plantas vasculares, distribuídas em 185 gêneros e 67 famílias, incluindo uma pteridófita (Marsilea deflexa - Marsileaceae). A família Fabaceae teve a maior riqueza (38 spp.), enquanto Ipomoea foi o gênero mais rico (9 spp.). O componente herbáceo foi o componente mais rico (43,6%), com uma predominância de herbáceas terófitas (57,5% de todas as plantas herbáceas). O estudo fitossociológico amostrou 1.988 indivíduos, distribuídos em 24 espécies de 13 famílias. As espécies com maior valor de importância foram Cordia oncocalyx e Croton blanchetianus, responsáveis por 63% dos indivíduos amostrados. Classificamos a área como Caatinga sensu stricto e em vegetação rupícola de inselbergues e afloramentos rochosos, chamando a atenção para a elevada riqueza de espécies no componente herbáceo, que, como em outras áreas de Caatinga sensu stricto, supera a riqueza de espécies lenhosas.

Abstract The Seasonally Dry Tropical Forests and Woodlands biome (SDTFW) has its largest nucleus in the Caatinga domain. We characterized the flora and physiognomy of the vegetation in the Pedra da Andorinha Wildlife Refuge (RPA), in Ceará, Brazil. Plant collections were made between March/2015 and May/2021, applying usual botanical methods. All material was deposited in HUVA herbarium. The phytosociological studies covered five 50 m x 50 m plots established (1.25 ha) in which all individuals with diameters at soil level ³ 3 cm were inventoried. We identified 266 vascular plants species distributed among 185 genera and 67 families, including one fern (Marsilea deflexa - Marsileaceae). Fabaceae had the greatest species richness (38 spp.), while Ipomoea was the richest genus (9 spp.). 43.6% of all plant species were herbaceous, with a predominance of therophytes (57.5% of all herbaceous plants). The phytosociological study sampled 1,988 individuals distributed among 24 species of 13 families. The species with the greatest important value were Cordia oncocalyx (Boraginaceae) and Croton blanchetianus (Euphorbiaceae). We classify the local physiognomy as typical caatinga sensu stricto vegetation and rocky vegetation on inselbergs and outcrops. We highlight the richness of herbaceous plants in the local community, which surpass the richness of the woody component.

https://doi.org/10.1590/2175-7860202273109

10.

More on the distribution of cladoceran species: gaps and perspectives in Rio de Janeiro State, southeastern Brazil
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Macêdo, Rafael Lacerda

; Sousa, Francisco Diogo R.

; Veras, Vinícius

; Elmoor-Loureiro, Lourdes M. A.

; Branco, Christina Wyss Castelo

Nauplius

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2022, Volume 30 elocation e2022032

Abstract: En | Text: En | PDF: En

Abstract Our knowledge of cladoceran species composition and distribution of Neotropical taxa is incomplete, therefore misleading the basic understanding of biodiversity processes and biogeographical patterns of this ecologically relevant group. We present new records and an updated checklist of the cladocerans of Rio de Janeiro State (Brazil) based on a critical review of their known distribution throughout the different freshwater ecoregions. Nine marine species were recorded, and 80 non-marine cladocerans were counted from two of the four ecoregions of Rio de Janeiro State. We estimate species richness applying the interpolation and extrapolation method, using iNEXT function. With this approach we compute diversity estimates for rarefied and extrapolated samples up to double the reference sample size (number of studies). Four new records of rare species were included from surveys in the Paraiba do Sul ecoregion. The Fluminense ecoregion shows a higher richness with a more asymptotic curve and thus a lower expected richness in comparison to the Paraiba do Sul ecoregion. Ceriodaphnia cornuta Sars, 1886 was the most frequently found species whilst Moina macrocopa Straus, 1820 was the only non-native species encountered. Our study can contribute to developing a biogeographical understanding of this diverse group in a heterogeneous territory in terms of inland waters. Future studies are suggested to prioritize novel ecoregions and unexplored habitats e.g. littoral zones with high macrophyte and periphyton coverage, brackish waters, saline and high-altitude lakes, as more diverse and heterogeneous habitats will undoubtedly reveal additional records.

https://doi.org/10.1590/2358-2936e2022032

11.

Beyond ‘A Clinical Lesson at La Salpêtrière’: a brief assessment of André Brouillet’s other paintings on medical subjects, life, and times
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PEDRO, Matheus Kahakura Franco

; SOUZA, Thiago Ferreira Simões DE

; GERMINIANI, Francisco Manoel Branco

; TEIVE, Hélio Afonso Ghizoni

; WALUSINSKI, Olivier

Arquivos de Neuro-Psiquiatria

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dec 2021, Volume 79 N. 12 Pages 1145 - 1148

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A famosa pintura ‘Une leçon clinique à la Salpêtrière’, de André Brouillet’s (1857-1914), é possivelmente a representação mais célebre da história da Neurologia. Seu retrato de uma das lendárias “lições de terça-feira” dirigidas por Jean-Martin Charcot inclui ainda não apenas uma das pacientes mais famosas do mestre como também seus pupilos, os fundadores da Neurologia moderna. Entretanto, o pintor propriamente dito é ainda negligenciado, e mesmo outras pinturas suas sobre temas médicos são pouco reconhecidas. Os autores trazem à atenção a vida e época de Brouillet, bem como o restante de seus outros trabalhos notáveis; dando contexto apropriado à pintura, neurologistas atuais podem compreender melhor a própria história de nossa especialidade e seu impacto cultural.

ABSTRACT André Brouillet’s (1857-1914) famous group tableau ‘A Clinical Lesson at La Salpêtrière’ (French: Une leçon clinique à la Salpêtrière) is possibly the most celebrated painting in the history of neurology. His depiction of one of Jean-Martin Charcot’s legendary “Tuesday Lessons” includes portraits of not only one of the master’s most famous patients, but also of his pupils, the heirs to the founder of modern neurology. However, the painter himself has long been neglected, and even his other paintings on medical subjects are little acknowledged. The authors aim to bring attention to Brouillet’s life and times, as well as the remainder of his notable works; and in giving a proper context to the famous painting, neurologists today may be able to appreciate better the early history of our field and its cultural impact.

https://doi.org/10.1590/0004-282x-anp-2021-0110 1 downloads

12.

Atualização da Diretriz Brasileira de Hipercolesterolemia Familiar – 2021
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Izar, Maria Cristina de Oliveira

; Giraldez, Viviane Zorzanelli Rocha

; Bertolami, Adriana

; Santos Filho, Raul Dias dos

; Lottenberg, Ana Maria

; Assad, Marcelo Heitor Vieira

; Saraiva, José Francisco Kerr

; Chacra, Ana Paula M.

; Martinez, Tania L. R.

; Bahia, Luciana Ribeiro

; Fonseca, Francisco Antonio Helfenstein

; Faludi, Andre Arpad

; Sposito, Andrei C.

; Chagas, Antônio Carlos Palandri

; Jannes, Cinthia Elim

; Amaral, Cristiane Kovacs

; Araújo, Daniel Branco de

; Cintra, Dennys Esper

; Coutinho, Elaine dos Reis

; Cesena, Fernando

; Xavier, Hermes Toros

; Mota, Isabela Cardoso Pimentel

; Giuliano, Isabela de Carlos Back

; Faria Neto, José Rocha

; Kato, Juliana Tieko

; Bertolami, Marcelo Chiara

; Miname, Marcio Hiroshi

; Castelo, Maria Helane Costa Gurgel

; Lavrador, Maria Sílvia Ferrari

; Machado, Roberta Marcondes

; Souza, Patrícia Guedes de

; Alves, Renato Jorge

; Machado, Valeria Arruda

; Salgado Filho, Wilson

Arquivos Brasileiros de Cardiologia

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oct 2021, Volume 117 N. 4 Pages 782 - 844

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210788 231 downloads

13.

A Desqualificação Social da classe média em Portugal: Uma abordagem qualitativa
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Vieira da Silva, Catarina

; Branco, Francisco

New Trends in Qualitative Research

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jun 2021, Volume 9 Pages 21 - 33

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: A presente investigação, tem como objeto central da pesquisa, analisar as principais dinâmicas de vulnerabilização que afetam a classe média, procurando-se compreender designadamente as dimensões relacionadas com a crise económica, quebra de rendimentos, processos de desagregação e rutura familiar, desqualificação social e sofrimento social. Este trabalho baseou-se, como um dos principais eixos teóricos de pesquisa, no ensaio de Serge Paugam sobre a nova pobreza. Partindo deste conceito como representação e categoria analítica, elaborou-se uma proposta de releitura do conceito de desqualificação social perante os desafios da classe média face à crise económica contemporânea. A pesquisa adotou uma estratégia de cariz qualitativo, com base em entrevistas a cidadãos de classe média que experienciaram no presente e passado recentes processos de desqualificação social, tendo sido reunido um corpus de vinte entrevistas com base no princípio da máxima heterogeneidade. No que se refere à codificação e categorização utilizou-se o software MAXQDA para a análise de dados qualitativos. Os dados recolhidos indiciam que estamos perante cidadãos que se afastam dos atributos apontados pela literatura à classe média, em consequência das trajetórias de mobilidade social descendente ou mobilidade ascensional estagnada provocadas pelos processos de vulnerabilização económica e social a que foram submetidos. Esta investigação permitiu ainda concluir que todos os entrevistados sofreram processos de mobilidade social descendente ou exposição a dinâmicas de mobilidade ascensional estagnada, evidenciando-se que uma grande parte dos cidadãos não recorre aos serviços de apoio e ação social, mobilizando preferencialmente as redes de apoio e solidariedade familiar.

Abstract: The present investigation, has the purpose to analyze the vulnerabilities that affect middle class families, pursuing the comprehension of the dimensions related to economical crisis, income and family breakdown, social disqualification and social suffering.This work was based, as one of the main theoretical axes of research, in Serge Paugam's essay on the new poverty. Based on this concept as representation and analytical category, a proposal was made to re-read the concept of social disqualification faced to the challenges of the middle class in the face of the contemporary economic crisis.This empirical research adopts a qualitative approach and is based on twenty interviews of middle-class citizens who experience or experienced social disqualification. The interviews have the principle of maximum heterogeneity. To apply coding and categorization, it was used MAXQDA software for the analysis of qualitative data.This research suggests we are facing citizens who deviate from the attributes pointed out by the literature to the middle class, as a result of the trajectories of downward social mobility or stagnant upward mobility caused by the processes of economic and social vulnerability to which they were subjected.All the interviewees suffered from processes of downward social mobility or dynamics of stagnant ascensional mobility, and that a large part of the citizens do not seek for social services, mobilizing support networks and family solidarity instead.

https://doi.org/10.36367/ntqr.9.2021.21-33 7 downloads

14.

O ensino da metodologia de investigação na formação inicial em Serviço Social: entre a transversalidade exigida e a predominância da metodologia qualitativa
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Monteiro, Daniela

; Branco, Francisco

New Trends in Qualitative Research

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jun 2021, Volume 7 Pages 95 - 106

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: O serviço social é uma profissão reconhecida pela sua intervenção junto das populações em situação de vulnerabilidade social. Mas, não se reduz a esta dimensão e a investigação tem ganho cada vez mais espaço na prática dos profissionais e destaque na literatura da área. Assim, importa compreender como formamos os estudantes e futuros profissionais neste domínio. Neste artigo, apresentamos uma parte de um estudo mais amplo sobre o ensino da investigação na formação inicial em serviço social, onde pretendemos conhecer e compreender as orientações metodológicas de investigação lecionadas na formação inicial em serviço social a partir da visão dos professores. Trata-se de um estudo de casos múltiplos de natureza qualitativa, cujas unidades de análise são três cursos de Licenciatura em Serviço Social em Portugal, onde foram entrevistados 12 professores. Os dados revelaram a preocupação que as IES (Instituições de Ensino Superior) demonstraram em garantir aos estudantes um conhecimento transversal das diferentes abordagens metodológicas, independentemente das tendências que marcam atualmente as investigações produzidas pelos assistentes sociais, o seu interesse ou adequação à área disciplinar e às metodologias preferencialmente adotadas pelos próprios professores enquanto investigadores. Conclui-se, ainda, que, não obstante esta transversalidade, verifica-se uma predominância da metodologia qualitativa nos trabalhos desenvolvidos pelos estudantes de serviço social numa associação com a natureza da intervenção da profissão.

Abstract: Social work is a profession recognized for its intervention with populations in situations of social vulnerability. However, it is not reduced to this dimension and research has gained more and more space in the practice of professionals and it is highlighted in the literature of the area. Thus, it is important to understand how we train students and future professionals in this field. In this article, we present a part of a broader study on the research teaching in initial training in social work, where we intend to know and understand the methodological guidelines of research taught in initial training in social work from the perspective of teachers. This is a multiple case study of a qualitative nature, whose units of analysis are three Degree courses in Social Work in Portugal, where 12 teachers were interviewed. The data revealed the concern that HEIs (Higher Education Institutions) demonstrated in guaranteeing students a transversal knowledge of the different methodological approaches, regardless of the current tendencies that mark the investigations produced by social workers, their interest or suitability to the disciplinary area and the methodologies preferably adopted by the teachers themselves as researchers. It is also concluded that, despite this transversality, there is a predominance of qualitative methodology in the works developed by social work students in association with the nature of the profession's intervention.

https://doi.org/10.36367/ntqr.7.2021.95-106 6 downloads

15.

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FRANKLIN, Gustavo Leite

; PEREIRA, Brunna Nicole Goulart Vitória

; LIMA, Nayra de Souza Carvalho

; GERMINIANI, Francisco Manoel Branco

; CAMARGO, Carlos Henrique Ferreira

; CARAMELLI, Paulo

; TEIVE, Hélio Afonso Ghizoni

Arquivos de Neuro-Psiquiatria

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apr 2021, Volume 79 N. 4 Pages 372 - 372

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/0004-282x-anp-2021-0132r 91 downloads

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