Abstract This article presents a study of the factors that influence the mechanism of soil-structure interaction with a pilot building having concrete walls and their impact on their performance. To illustrate the studies carried out, a numerical modeling of a four-floor concrete wall pilot building was performed, subjected to vertical actions, supported by a slab-on-ground foundation, using the Finite Element Method (FEM), together with specific 3D software for analysis and structural dimensioning in reinforced concrete. For the consideration of the geotechnical and structural system (foundation structure), the discrete spring model (Winkler model) coupled to the superstructure was used and the slab foundation thickness was varied by 16 cm, 25 cm and 40 cm. The local geotechnical formation was represented by a soft clay (SPT = 5) from the Belo Horizonte Metropolitan Region, Brazil. The influential factors of the SSI analyzed in this research were: relative stiffness of the foundation structure, requesting stresses, settlements in the foundation of the building and steel reinforcement bar ratio. For a better visualization of the influence of these various factors, an analysis was made of the distribution of normal stresses and stresses at the base of the walls of this building, in the form of graphs. Finally, it was concluded that the change in slab foundation, stiffness influences the distribution of stresses and stresses in the foundation, with a tendency to uniformity as the slab foundation thickness increases. However, this relationship is not linear.