Abstract Introduction: Whole-body cryotherapy (WBC) has shown to be beneficial in the treatment of fibromyalgia (FM). There is cumulative evidence that cytokines play a crucial role in FM. It's unknown whether clinical effects of WBC can be demonstrated at the molecular level and how long the effects last. Methods: We compared effects of serial WBC (6 sessions (- 130 °C in 6 weeks) in FM patients and healthy controls (HC). Primary outcome was the change in pain level (visual analogue scale 0-100 mm) after 6 sessions. Secondary outcomes were a change in disease activity (revised Fibromyalgia Impact Questionnaire) and pain after 3 sessions and 3 months after discontinued therapy and in cytokine levels (interleukin (IL-)1, IL-6, tumor necrosis factor α (TNF-α) and IL-10). The patients’ opinions on the satisfaction, effectiveness and significance of WBC were evaluated. Results: Twenty-three FM patients and 30 HC were enrolled. WBC resulted in a significant reduction in pain and disease activity after 3 and 6 sessions. No clinical benefit could be measured 3 months after discontinued treatment. Overall, probands were satisfied with WBC and considered WBC to be important and effective. FM patients had significantly different levels of IL-1, IL-6, TNF-α and IL-10 at each reading point compared to HC. Levels of IL-1, IL-6 and IL-10 were significantly altered over time in FM patients. Compared to HC FM patients showed a significantly different response of IL1, - 6 and - 10 to WBC. Conclusion: Serial WBC is a fast acting and effective treatment for FM. Proven effects of WBC may be explained by changes in cytokines.

Abstract The early detection of failures in structures is a subject of great interest in engineering; several of these techniques are linked with the elastic wave propagation, using guided waves is one of these alternatives. Several structures of interest in engineering are laminar arrangements; the wave propagation in this type of structures depends not only on the material properties, but also on the geometric parameters, such as the plate thickness. Tubular structures, pressure vessels, tanks and also parts of ships hulls could be considered laminar. The elastic wave propagation in laminar structures could be considered as a sum of modal shapes that have its wave length and frequencies defined. These mode families are characteristics of each structure and could be represented through the dispersion curves. The definition of these dispersion curves is of crucial importance to understand the propagation of guided waves in the structure studied. In the present work the dispersion curves were generated using three different methodologies, specific for metallic rectangular stems that compound the strengthening armor in flexible riser duct. Each approach presented in the analysis were carried out using standard finite element commercial packages and an experimental verification, as well. The premise is to present the topics in the simplest way, not only to understand how the dispersion curves are built but also how these curves must be interpreted.

Abstract Currently, there are a lot of research activities dealing with gamma titanium aluminide (γ-TiAl) alloys as new materials for low pressure turbine (LPT) blades. Even though the scatter in mechanical properties of such intermetallic alloys is more distinctive as in conventional metallic alloys, stochastic investigations on γ -TiAl alloys are very rare. For this reason, we analyzed the scatter in static and dynamic mechanical properties of the cast alloy Ti-48Al-2Cr-2Nb. It was found that this alloy shows a size effect in strength which is less pronounced than the size effect of brittle materials. A weakest-link approach is enhanced for describing a scalable size effect under multiaxial stress states and implemented in a post processing tool for reliability analysis of real components. The presented approach is a first applicable reliability model for semi-brittle materials. The developed reliability tool was integrated into a multidisciplinary optimization of the geometry of a LPT blade. Some processes of the optimization were distributed in a wide area network, so that specialized tools for each discipline could be employed. The optimization results show that it is possible to increase the aerodynamic efficiency and the structural mechanics reliability at the same time, while ensuring the blade can be manufactured in an investment casting process.

RESUMO: Amorimiapubiflora(Malpighiaceae) contém monofluoroacetato de sódio (MFA) e é uma das principais causas de "morte-súbita" em bovinos no estado de Mato Grosso, no Brasil. Este trabalho investiga a indução de resistência à intoxicação por A. pubiflora em ovinos, através da administração repetida de doses não tóxicas, e também se é possível transferir essa resistência para outros ovinos por transfaunação do fluido ruminal. Para a indução à resistência, um grupo com quatro ovinos (G1) recebeu doses diárias individuais de 0,5g kg-1 de folhas de A. pubiflora durante 20 dias. Após um intervalo de 15 dias, os ovinos desse grupo foram desafiados diariamente, durante 3 dias consecutivos, com a dose de 1g kg-1. A transferência de resistência à intoxicação por A. Pubiflora foi avaliada por transfaunação de conteúdo ruminal (100ml diariamente durante 10 dias) do G1, para cinco ovinos (G2). Após essa etapa, os cinco ovinos do Grupo G2 receberam a dose de 1g kg-1 por três dias (G2D2) e, após um intervalo de 3 dias, quatro ovinos do G2 receberam uma única dose de 3g kg-1 (G2D3). O grau de resistência foi conferido mediante o monitoramento do início dos sinais clínicos, frequência cardíaca, desfecho da intoxicação e comparação com grupos controle, os quais foram desafiados com três doses repetidas de 1g kg-1 (G3) e uma dose única de 3g kg-1 (G4). Os parâmetros clínicos avaliados nos Grupos G1 e G2 foram significativamente menos evidentes do que os observados nos G3 e G4 (controles) (P<0,05). Os ovinos do G4 (controle) morreram após receber a dose única de 3g kg-1, enquanto os do G2 (transfaunados) sobreviveram. Esses achados indicam que o consumo de doses não tóxicas de A. pubiflora induz resistência em ovinos e que a resistência pode ser transferida por transfaunação. Novos experimentos são necessários para determinar as formas mais práticas para induzir resistência e a forma de usar essa técnica no campo para controlar a intoxicação por essa planta.

ABSTRACT: Amorimiapubiflora (Malpighiaceae), which contains sodium monofluoroacetate (MFA) is the main cause of "sudden death" in cattle in the Brazilian state of Mato Grosso. This research investigated the induction of resistance to the poisoning in sheep by the continuous administration of non-toxic doses of the plant and also the possibility to transfer this resistance to other sheep by the transfaunation of ruminal fluid. For this a group of four sheep (G1) received daily doses of 0.5g kg-1 for 20 days and after an interval of 15 days were challenged with three daily doses of 1g kg-1 for 3 days. Also the transfer of resistance to A. pubiflora poisoning was evaluated by transfaunation of rumen fluid (100ml for 10 days) from G1 sheep to five sheep (G2), followed by challenge with the dose of 1g kg-1 for 3 days (G2D2) and after a three-day interval they received a single dose of 3g kg-1 (G2D3). The degree of resistance was evaluated by monitoring the onset of clinical signs, heart rate, and outcome of the poisoning compared with the control groups, which were challenged with three daily doses of 1g kg1 (G3) and with a single dose of 3g kg-1 (G4). Clinical parameters evaluated in Groups G1 and G2 were significantly less pronounced than those observed in G3 and G4 (control) (P<0.05). Sheep in G4 (control) died after receiving a single dose of 3g kg-1, while those in G2 (transfaunated) survived. These findings demonstrated that consumption of non-toxic doses of A. pubiflora induced resistance in sheep and that this resistance can be transferred by transfaunation. New experiments are needed to determine the most efficient ways to induce resistance and to use this technique in the field to prevent the poisoning.

En esta serie de experimentos utilizamos un juego iterativo del "Dilema del Prisionero" (IPDG por sus siglas en inglés) para examinar el efecto de las metacontingencias sobre los productos agregados del comportamiento interrelacionado de cuatro jugadores. Los resultados del primer experimento muestran que las consecuencias de nivel cultural ("retroalimentación del mercado" en la forma de puntos entregados a todos los jugadores), contingentes con los productos agregados XXX o YYYY aumentaron la frecuencia de esas producciones. En experimentos posteriores, añadimos una condición de línea de base en la cual los jugadores experimentaron solo las contingencias conductuales individuales incorporadas en el juego. Luego impusimos la metacontingencia sobre el producto agregado XXXX, o de forma alternativa sobre YYYY. Después de varias reversiones, descontinuamos la metacontingencia y los jugadores comenzaron a experimentar nuevamente solo las contingencias individuales del juego. En un experimento utilizamos un control para evaluar el efecto de la retroalimentación del mercado de manera independiente de la relación metacontingencial. Los resultados indican que la consecuencia cultural (retroalimentación del mercado) controló la producción de productos agregados incluso cuando su magnitud era mínima, que la relación metacontingencial era necesaria, y que mantenía relaciones en el comportamiento de los individuos que tenían los peores resultados para todos los jugadores.

In these series of experiments we used an iterated prisoners' dilemma game (IPDG) to examine the effect of metacontingencies on aggregate products of the interrelated behavior of four players. Results of the first experiment showed that cultural level consequences ("market feedback" in the form of points delivered to all players) contingent on aggregate products XXXX or YYYY increased the frequency of those productions. In subsequent experiments we added a baseline condition where the players experienced only the individual behavioral contingencies embedded in the game. Then we imposed the metacontingency on the XXXX aggregate product or, alternatively, on YYYY. After several reversals, we discontinued the metacontingency and the players again experienced only the individual contingencies of the game. In one experiment we used a yoked control to assess the effect of market feedback independent from the metacontingency relation. Results indicate that the cultural consequence (market feedback) controlled production of aggregate products even when its magnitude was minimal, that the metacontingency relation was necessary, and that it maintained relations among the behavior of individuals which resulted in the worst individual outcomes for all players.

La Oficina Regional para Europa de la Organización Mundial de la Salud (OMS) en Copenague estableció un grupo de trabajo sobre evaluación en Salud Mental formado por expertos en Psiquiatría, los cuales, junto con los centros colaboradores de la OMS, prestan asistencia a una red Europea de Salud Mental constituido por 47 representantes nacionales para la Salud Mental nombrados por los diferentes ministerios. Este artículo discute las evaluaciones que se han hecho en siete estados de la Europa del Este y del Sureste durante los tres años de vida del grupo de trabajo. La mayoría de los instrumentos de evaluación que se utilizan en la actualidad exigen estudios de campo largos y costosos, que rara vez son posibles en el contexto de este tipo de evaluación. En el futuro se deberá hacer un esfuerzo considerable para consensuar procedimientos simples y fiables para evaluar estos parámetros y controlar la evolución. Por lo general, las evaluaciones descritas aumentaron el interés y la sensibilidad por las cuestiones de Salud mental, colocando de esta manera estas cuestiones en el centro de la política en la mayoría de los países concernidos.