ABSTRACT This article addresses the importance of Internationalization Policies in Higher Education Institutions (HEIs) and aims to describe the technical-methodological aspects taken into account in the construction of Strategic Internationalization Plans within the framework of the project called "Development of Internationalization Policies". Internationalization in Higher Education Institutions” (DHIP1) and reflect them in marketing actions to improve services. The institutional international strategy, the structure of the International Relations Offices (ORIs), international mobility, the internationalization of the curriculum, the internationalization of research, synergy with the territorial context and visibility, were the priorities addressed, therefore, the conclusions refer to the continuous improvement of the internationalization process related to these priorities and how they contribute to the quality of the ORIs services. For the elaboration of this paper, a qualitative approach of documentary analysis was taken into account. Horizontal cooperation between HEIs, both from Latin America, Europe, and also from other regions of the world, constitutes an essential tool for the achievement of the Policies that are designed in each HEI.

RESUMEN El presente artículo aborda la importancia de las Políticas de Internacionalización en las Instituciones de Educación Superior (IES) y pretende describir y documentar los aspectos técnicos-metodológicos tenidos en cuenta en la construcción de los Planes Estratégicos de Internacionalización el marco del proyecto denominado “Desarrollo de Políticas de Internacionalización en las Instituciones de Educación Superior” (DHIP), además de reflejarlos en acciones de marketing para mejorar los servicios. La estrategia internacional institucional, la estructura de las Oficinas de Relaciones Internacionales (ORIs), la movilidad internacional, la internacionalización del currículum, la internacionalización de la investigación, la sinergia con el contexto territorial y la visibilidad, fueron las prioridades atendidas, por tanto, las conclusiones se refieren a la mejora continua del proceso de internacionalización relacionadas a dichas prioridades y como estas contribuyen a la calidad de los servicios de las ORIs. Para la elaboración del presente artículo se tuvo en cuenta un enfoque cualitativo de análisis documental. La cooperación horizontal entre IES, tanto de América Latina, de Europa, y también de otras regiones del mundo, constituye una herramienta esencial para el logro de las Políticas que se diseñan en cada IES.

Abstract Multiple myeloma (MM) is a hematological malignancy characterized by unregulated and clonal proliferation of plasma cells in the bone marrow; these cells produce and secrete an anomalous monoclonal immunoglobulin, or a fragment of this, called M protein. The clinical manifestations of MM result from the proliferation of these plasmocytes, the excessive production of monoclonal immunoglobulin and the suppression of normal humoral immunity, leading to hypercalcemia, bone destruction, renal failure, suppression of hematopoiesis and humoral immunity, increasing the risk for the development of infections. The increase in life expectancy of the world population led to a concomitant increase in the prevalence of MM, a pathology that usually affects the elderly population. The aim of this review is to update the reader on epidemiology, diagnostic criteria, differential diagnosis with other monoclonal gam-mopathies, systemic treatment and prognosis of MM.

Resumo O mieloma múltiplo (MM) constitui neoplasia maligna de origem hematológica caracterizada pela proliferação desregulada e clonal de plasmócitos na medula óssea; estas células produzem e secretam imunoglobulina monoclonal anômala, ou um fragmento desta, denominado proteína M. As manifestações clínicas do MM decorrem da proliferação destes plasmócitos, da produção excessiva de imunoglobulina monoclonal e da supressão da imunidade humoral normal, levando à hipercalcemia, destruição óssea, insuficiência renal, supressão da hematopoiese e da imunidade humoral,aumentandooriscoparaodesenvolvimento de infecções. O aumento na expectativa de vida da população mundial levou a concomitante incremento na prevalência do MM, patologia que habitualmente acomete a população idosa. O objetivo desta revisão é atualizar o leitor sobre a epidemiologia, critérios diagnósticos, diagnóstico diferencial com outras gamopatias monoclonais, tratamento sistêmico e prognóstico do MM.

Abstract The increase in life expectancy of the world population has led to a concomitant increase in the prevalence of multiple myeloma (MM), a disease that usually affects the elderly population. Bone lesions are frequent in patients with this condition, demanding an early approach, from drug treatment, through radiotherapy to orthopedic surgery (prophylactic or therapeutic) with the objective of preventing or delaying the occurrence of fracture, or, when this event has already occurred, treat it through stabilization or replacement (lesions located in the appendicular skeleton) and/or promote stabilization and spinal cord decompression (lesions located in the axial skeleton), providing rapid pain relief, return to ambulation and resocialization, returning quality of life to patients. The aim of this review isto update the reader on the findings of pathophysiology, clinical, laboratory and imaging, differential diagnosis and therapeutic approach of multiple myeloma multiple myeloma bone disease (MMBD).

Resumo O aumento da expectativa devida da população mundial levou a incremento concomitante na prevalência de mieloma múltiplo (MM), patologia que geralmente afeta a população idosa. Lesões ósseas são frequentes nos portadores desta condição, demandando abordagem precoce, desde o tratamento medicamentoso, passando pela radioterapia até a cirurgia ortopédica (profilática ou terapêutica) com os objetivos de prevenir ou retardar a ocorrência de fratura, ou, quando este evento já ocorreu, tratá-la mediante estabilização ou substituição (lesões situadas no esqueleto apendicular) e/ou promover estabilização e descompressão medular (lesões situadas no esqueleto axial), proporcionando rápido alívio da dor, retorno à deambulação e ressocialização, devolvendo a qualidade de vida aos pacientes. O objetivo desta revisão é atualizar o leitor sobre a fisiopatologia, a clínica, exames laboratoriais e de imagem, diagnóstico diferencial e abordagem terapêutica da doença óssea no mieloma múltiplo (DOMM).

Background: Vena cava (VC) involvement in kidney tumors occurs in 4 to 10% of cases, and is associated with a higher mortality. Nephrectomy with thrombectomy of the VC, performed by a multidisciplinary team, improves survival. Aim: To report a series of consecutive nephrectomies with caval thrombectomy performed in an academic center. Patients and Methods: We report 32 patients with cT3b and 3c renal tumors, who underwent radical nephrectomy with VC thrombectomy between 2001 and 2021. A descriptive analysis of clinical, surgical and pathological variables was performed. Overall survival (OS) and cancer-specific survival (CSS) was calculated using Kaplan-Meier curves. Results: The mean tumor size was 9.7 cm. According to Mayo classification 3/32 (9%) patients had a type I thrombus, 10/32 (31%) had a type II thrombus, 8/32 (25%) had a type III thrombus, and 5/32 (16%) had a type IV thrombus. The mean bleeding was 2000 cc. There was one intraoperative death. Nineteen percent of patients had complications >= 3 according to Clavien-Dindo classification. Reoperations occurred in 9%. Pre and postoperative creatinine levels were 1.17 and 1.91 mg/dl respectively (p < 0.01). Pre and postoperative Hematocrit levels were 47.9 and 31% respectively (p = 0.02). Sixty six percent of tumors were clear cell renal cancer, 9% were papillary and 3% were chromophobic. Mean OS was 10 months. Two-year SCE was 40%. Conclusions: Our results are similar to those reported elsewhere. Despite being an unusual pathology, the surgical technique has been improving, thanks to the multidisciplinary work of urologists and surgeons.

Abstract Background: Sarcopenia is a disease that involves skeletal muscle mass loss and is highly prevalent in the older adult population. Moreover, the incidence of sarcopenia is increased in patients with hypertension. Objectives: The study aimed to evaluate the association between the classes of the drugs used for arterial hypertension treatment and the presence or absence of sarcopenia. Methods: 129 older adults with hypertension were evaluated by the researchers who registered the participants medication for arterial hypertension treatment. Sarcopenia level was measured by anthropometric parameters, muscular strength, and functional capacity. The data were analyzed by one-way ANOVA followed by post-hoc test and Fisher’s exact test; statistical significance was set at 0.05. Results: Age was not different between women with different levels of sarcopenia, but significant differences were observed between men with absent sarcopenia (66.8±4.2 years) and men with probable sarcopenia (77.0±10.2 years). Individuals with absent sarcopenia showed higher handgrip strength (men: 33.8±7.4, women: 23.2±4.6 Kgf) in comparison with those with sarcopenia (men with probable sarcopenia: 9.5±3.3 Kgf, women with probable, confirmed, and severe sarcopenia: 11.7±2.5, 12.2±3.0, 11.8±1.8 Kgf, respectively). The analysis showed an association between the type of medication and degree of sarcopenia; diuretics were significantly associated with probable sarcopenia, and angiotensin II receptor blockers (alone or in combination with diuretics) was associated with absence of sarcopenia. Conclusion: In conclusion, handgrip strength was a good method to diagnose sarcopenia, and diuretics were associated with increased risk of sarcopenia in older adults with hypertension.

ABSTRACT The production of strawberry seedlings in a soilless cultivation system can be an alternative for the production of seedlings of high physiological and sanitary quality. The objective of this study was to evaluate the influence of the use of different nutrient solutions in mother plants on the production and quality of strawberry seedlings of the Aromas and Camarosa cultivars. The experiment was carried out in two crop cycles: the first cycle in 2016/2017, where four different nutrient solutions (1; 2; 3 and 4) were used for the nutrition of the parent plants of the cultivars under study and the second in 2017/2018, when the most productive solutions (nutrient solution 3 and 4) based on the results of the first cycle were used, together with the two cultivars. The propagules produced were collected, evaluated and rooted in substrate-filled trays, forming plant plugs, which were evaluated for quality. Nutritional solutions influence the propagative potential of the parent plants more than the physiological quality of the plug plant seedlings produced, when they are formed on substrates that provide nutrients. The nutrient solution 4 is the most recommended for the production of strawberry seedlings of the cultivars Aromas and Camarosa, in a soilless system.

ABSTRACT This review article aims to address relevant aspects of personal and family finances, taking into account that, due to the pandemic crisis, it is necessary to make a change in personal perspective and attitudes regarding money management; take steps to help choose actions to design a personal finance management plan. The content is based on the compilation of information in existing bibliographies regarding finances at the business level adapted to the personal level; therefore, it obeys document analysis. The conclusions refer to the personal relationship with financial stability, financial education, the budget and financial peace.

RESUMEN Este artículo de revisión pretende abordar aspectos relevantes de las finanzas personales y familiares atendiendo que, a causa de la crisis pandémica, resulta necesario realizar un cambio de perspectiva personal y de actitudes con relación a la gestión del dinero; tomar medidas que ayuden a elegir acciones para diseñar un plan de administración de las finanzas personales. El contenido está basado en la recopilación de información en bibliografías existentes respecto a las finanzas a nivel empresarial adaptadas al nivel personal; por tanto, obedece al análisis de documentos. Las conclusiones hacen referencia a la relación personal con la estabilidad financiera, la educación financiera, el presupuesto y la paz financiera.

Abstract Fruit coproducts fruit, made of peels, seeds and pulp, discarded during the industrial processing, contain lots of health beneficial compounds, however, high moisture content limits its use. Drying is a low cost and great potential alternative for using. This study aimed to evaluate the phenolic compounds content, in vitro antioxidant capacity and total carotenoid, anthocyanins and vitamin C contents of pineapple (Ananas comosus), banana (Musa sp.), lychee (Litchi chinensis) and papaya (Carica papaya) peels, fresh and oven dried at 55 °C. Phenolic compounds, total carotenoids, anthocyanins, vitamin C contents and the antioxidant capacity of flours, were also significantly higher, indicating that the drying process promoted the concentration of these components, and constitute an excellent alternative to use these coproducts as a source of nutrients.

RESUMO Introdução Viscossuplementação e treinamento de força são intervenções propostas no tratamento da osteoartrite de joelho. Objetivo Descrever a resposta isocinética em mulheres com osteoartrite de joelho submetidas a ambas intervenções. Métodos Ensaio clínico duplo-cego e randomizado envolvendo 30 mulheres com diagnóstico de osteoartrite bilateral de joelho de graus II e III utilizando os critérios radiológicos de Kellgren & Lawrence. Elas foram randomizadas em três grupos de dez pacientes cada: um grupo foi submetido à viscossuplementação e ao treinamento de força (VTF), o outro submetido ao treinamento de força (TF) e o terceiro grupo foi submetido apenas à viscossuplementação (VS). Todas as avaliações seguiram as fases do estudo definidas como pré-procedimento (PRE); após 48 horas da VS (POS-VS); após 12 semanas de treinamento (POS T) e após oito semanas de destreinamento (POS D). Foram realizadas infiltrações intra-articulares de joelho com uma dose única de Hilano GF-20 e dinamometria isocinética para determinar o torque máximo em extensão e em flexão do joelho. A dor foi medida através da escala visual analógica (EVA). Resultados As intervenções promoveram melhorias na resposta isocinética em todos os três grupos e em ambos grupos musculares, com vantagem para o grupo extensor. Observou-se uma diferença significativa na resposta isocinética dos grupos treinados quando comparados ao grupo somente viscossuplementado (p<0,005), além disso o grupo VTF apresentou melhor resposta isocinética quando comparado ao grupo TF. Conclusão O tratamento combinado de viscossuplementação e treinamento de força e o tratamento com o treinamento de força apenas apresentaram melhores resultados na resposta isocinética e na redução da dor do que o tratamento apenas com viscossuplementação. Nível de evidência I; Estudos terapêuticos–Investigação dos resultados do tratamento.

ABSTRACT Introduction Viscosupplementation and strength training are proposed interventions in the treatment of knee osteoarthritis. Objective To describe the isokinetic response in women with knee osteoarthritis who underwent both interventions. Methods A double-blind, randomized clinical trial involving thirty women diagnosed with grade II and III bilateral knee osteoarthritis using the radiological criteria of Kellgren & Lawrence. The subjects were randomized into three groups of ten patients each: one group was submitted to viscosupplementation and strength training (VST), another was submitted to strength training (ST) only, and a third to viscosupplementation (VS) only. All evaluations followed the study phases defined as pre-procedure (PRE); after 48 hours of VS (POS-VS); after 12 weeks of training (POS T); and after eight weeks of detraining (POS D). Intra-articular knee infiltrations were performed with a single dose of Hylan GF-20 and isokinetic dynamometry to determine the maximum torque in knee extension and flexion. Pain was measured by the visual analogue scale (VAS). Results The interventions promoted improvements in the isokinetic response in all three groups and in both muscle groups, with advantage for the extensor group. A significant difference was noticed in the isokinetic response of the trained groups when compared only to the viscosupplemented group (p<0.005), and the VST group showed better isokinetic response compared to the ST group. Conclusion Combined treatment with viscosupplementation and strength training, and treatment with strength training only, presented better results in terms of isokinetic response and pain reduction than viscosupplementation alone. Level of evidence I; Therapeutic studies-Investigating the results of treatment.

RESUMEN Introducción Viscosuplementación y entrenamiento de fuerza son intervenciones propuestas en el tratamiento de osteoartritis de rodilla. Objetivo Describir la respuesta isocinética en mujeres con osteoartritis de rodilla sometidas a ambas intervenciones. Métodos Ensayo clínico doble ciego y aleatorizado que involucró a 30 mujeres con diagnóstico de osteoartritis bilateral de rodilla de grados II y III utilizando los criterios radiológicos de Kellgren y Lawrence. Ellas fueron aleatorizadas en tres grupos con diez pacientes cada uno: un grupo fue sometido a viscosuplementación y al entrenamiento de fuerza (VEF), el otro sometido al entrenamiento de fuerza (EF) y el tercer grupo sometido sólo a la viscosuplementación (VS). Todas las evaluaciones siguieron las fases del estudio definidas como pre-procedimiento (PRE); después de 48 horas de la VS (POS-VS); después de 12 semanas de entrenamiento (POS E) y después de ocho semanas de desentrenamiento (POS D). Fueron realizadas infiltraciones intraarticulares de rodilla con una dosis única de Hilano GF-20 y dinamometría isocinética para determinar el torque máximo en extensión y en flexión de rodilla. El dolor fue medido a través de la escala visual analógica (EVA) Resultados: Las intervenciones promovieron mejoras en la respuesta isocinética en los tres grupos y en ambos grupos musculares, con ventaja para el grupo extensor. Se observ ó una significativa diferencia en la respuesta isocinética de los grupos entrenados cuando comparados solamente al grupo viscosuplementado (p<0,005), además el grupo VEF presentó mejor respuesta isocinética cuando comparado al grupo EF. Conclusión El tratamiento combinado de viscosuplementación y entrenamiento de fuerza y el tratamiento con entrenamiento de fuerza sólo presentaron mejores resultados en la respuesta isocinética y en la reducción del dolor que el tratamiento con sólo viscosuplementación. Nivel de evidencia I; Estudios terapéuticos-Investigación de los resultados del tratamiento.

RESUMO: Neste trabalho apresenta-se um estudo experimental da variação espacial da dureza ou resistência à indentação de um concreto autoadensável. Inicialmente é apresentada a comparação da metodologia utilizada com os valores obtidos por simulação numérica com o intuito de validação da mesma. O comprimento de correlação (Lcor) obtido do semivariograma utilizando o modelo Gaussiano é próximo ao valor simulado numericamente, especialmente quando a distância entre os pontos medidos é menor que o Lcor procurado. Utilizando esclerometria foi possível concluir que para encontrar o valor do comprimento de correlação do concreto é necessário realizar medições em pontos próximos, na ordem de 2cm. Com esta metodologia, o valor de Lcor encontrado é próximo ao obtido utilizando macro-indentação, procedimento esse mais complexo e demorado. Assim, para o concreto autoadensável em estudo, encontrou-se o comprimento de correlação equivalente a um valor entre 5 a 6 vezes o tamanho máximo do agregado graúdo.

ABSTRACT: This paper presents an experimental study of spatial variation of hardness or indentation strength of a self-compacting concrete. With the pourpose of validation, the comparison between the used methodologies with the values obtained by numerical simulation is presented. The correlation length (Lcor) obtained on the semivariogram using a Gaussian model is similar to the numerically simulated value, especially when the distance between the measurements is less than the sought Lcor. Using sclerometry, it was possible to infer that to find the value of concrete correlation length it is necessary to measure nearby points, at ca. 2cm apart. With this scheme, the value of Lcor found is close to the obtained using macro-indentation, a more complex and time-consuming procedure. Finally, for the studied self-compacting concrete, the correlation length is equivalent to a value between 5 to 6 times the maximum aggregate size.

Abstract The rheological behavior of poly (butylene adipate-co-terephthalate) (PBAT) and its composites prepared with three different organoclays was investigated. Composites containing up to 7.5%, w/w organoclay, were prepared by two routes: (a) direct melt blending in an internal laboratory mixer with high intensity rotors and (b) concentrates (prepared in the internal mixer) with 50 %, by weight, of the organoclays diluted in a co-rotating twin screw extruder equipped with a high intensity mixing thread operating at a nominal speed of 480 rpm. The samples were characterized by both torque and parallel plate rheometry. Results indicate that nanodispersions in the clay layers were obtained during processing and that, like the pure matrix, at high shear rates, the organoclay compounds follow the power law, although with higher viscosity. It is believed that the interaction of the polymer with the organoclay is responsible for the increase in melt viscosity (observed by increases in torque and relaxation time) of the hybrid systems.

RESUMO Os transtornos mentais comuns (TMC) estão cada vez mais frequentes na população mundial, apresentando-se menos graves que outros grupos de transtornos mentais. Estão associados a perda de qualidade de vida, problemas de relacionamento e sofrimento psíquico. Estudos que investigam prevalência de TMC são normalmente voltados ao âmbito ocupacional, acadêmico e da saúde. Estudos brasileiros na área de saúde mental realizados com estudantes de Medicina apontam que entre 30% e 44% de suas amostras apresentam algum tipo de transtorno mental comum ou sintoma nesse grupo. O objetivo do presente estudo é identificar a prevalência de TMC entre os estudantes de Medicina da Universidade Regional de Blumenau (SC). Trata-se de um estudo transversal, realizado de agosto a outubro de 2017, com 340 alunos do primeiro ao décimo segundo semestre do curso de Medicina. Para o rastreamento de TMC foi utilizado o Self-Reporting Questionnaire (SRQ-20). A prevalência de TMC encontrada foi de 50,9%. Os TMC apresentaram-se associados (p < 0,05) a carga horária média por dia maior que 12 horas, menos de uma hora de lazer por dia, sentir que não recebe apoio emocional necessário, ter história médica pregressa de doença psiquiátrica, usar antidepressivo, nunca ter feito psicoterapia ou tê-la abandonado antes de receber alta e uso de álcool e outras substâncias. Foi encontrada maior prevalência de casos suspeitos de TMC na presente amostra do que em outros estudos com alunos dos cursos de Medicina brasileiros. A prevalência de TMC no internato mostrou-se semelhante à dos dois primeiros ciclos do curso, apesar da presença de fatores protetores demonstrados na literatura. É fundamental a atenção da universidade para atividades de promoção de saúde, juntamente com os serviços de saúde e com a família, formando uma rede de apoio psicológico. Para isso, são apresentados subsídios para ações de prevenção e cuidado da saúde mental do estudante de Medicina.

ABSTRACT Common mental disorders (CMDs) are increasingly frequent in the world’s population and are less severe than other groups of mental disorders. They are associated with loss of quality of life, relationship problems and psychological suffering. The studies that investigate the prevalence of CMDs are aimed at the occupational, academic and health levels. Brazilian studies in the area of Mental Health carried out with medical students indicate that 30% and 44% of this group has some type of common mental disorder or symptom. The aim of the present study is to detect CMDs among medical students from Universidade Regional de Blumenau/SC. This is a cross-sectional study carried out in August 2017 with 340 students from the 1st to the 12th semester of School. The Self-Reporting Questionnaire (SRQ-20) was used for CMD screening. The prevalence of CMD was 50.9%. Classic CMDs were associated (p <0.05) with the mean daily workload of more than 12 hours, less than one hour of leisure per day, having a previous medical history of psychiatric illness, using antidepressants, never having attended or been discharged from psychotherapy and the use of alcohol and other substances. A higher rate of suspected CMD cases was found in the present sample than in other studies with students from other Brazilian Medical Schools. The presence of CMD during the internship cycle was similar to that observed in the early cycles of medical school, despite the presence of protective factors, as demonstrated in the literature. The university must direct its attention to health promotion activities, together with health services and the family, creating a psychological support network. For this purpose, it has subsidies to establish prevention and care actions directed at the mental health of medical students.