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Tuberculosis associated with diabetes mellitus by age group in Brazil: a retrospective cohort study, 2007-2014
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Evangelista, Maria do Socorro Nantua

; Maia, Rosalia

; Toledo, João Paulo

; Abreu, Ricardo Gadelha de

; Barreira, Draurio

Brazilian Journal of Infectious Diseases

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apr 2020, Volume 24 N. 2 Pages 130 - 136

Abstract: En | Text: En | PDF: En

ABSTRACT Diabetes mellitus (DM) has important implications for tuberculosis (TB), as it increases the risk for disease activation and is associated with unfavorable TB treatment outcomes. This study analyzed the association between TB and DM (TBDM) in Brazil from 2007 to 2014. This was a retrospective cohort study carried out in 709,429 new cases of TB reported to the national disease notification system of the Brazilian Ministry of Health. Sociodemographic and clinical data, test results, and treatment outcomes were analyzed. TBDM was found in 6.0% of TB cases, mostly in men aged 18-59 years. The lethality rate was 5.1% higher in all age groups with diabetes, except in those older than 60 years of age. The frequency of multi-drug-resistant tuberculosis (MDR-TB) in patients with DM was higher in those without DM, with a 1.6- to 3.8-fold increase in the odds of MDR-TB. The elderly showed an increase in the prevalence of TBDM from 14.3% to 18.2%. Women were more likely to have DM, and elderly women had 41.0% greater chance of having DM. Relapse was significant among patients younger than 17 years of age. TBDM was high in Brazil, affected all age groups, and was associated with unfavorable TB treatment outcomes. We emphasize the need for strategies for the clinical management of diabetic tuberculosis patients in Brazil aiming at minimizing relapses, deaths, and MDR-TB.

https://doi.org/10.1016/j.bjid.2020.03.005 398 downloads

Sistema de Informação de Tratamentos Especiais de Tuberculose (SITE-TB): histórico, descrição e perspectivas
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Bartholomay, Patricia

; Pinheiro, Rejane Sobrino

; Pelissari, Daniele Maria

; Arakaki-Sanchez, Denise

; Dockhorn, Fernanda

; Rocha, Jorge Luiz

; Penna, Estefania Quilma Andrade de Araújo

; Barreira, Draurio

; Araújo, Wildo Navegantes de

; Dalcolmo, Margareth

Epidemiologia e Serviços de Saúde

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2019, Volume 28 N. 2 elocation e2018158

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo O Sistema de Informação de Tratamentos Especiais de Tuberculose (SITE-TB) surgiu da necessidade principal de monitorar, rotineiramente, todas as pessoas com tuberculose drogarresistente (TBDR) no Brasil, e qualificar o controle dos fármacos antituberculose. Desenvolvido pelo Centro de Referência Professor Hélio Fraga e pelo projeto Management Sciences for Health/Brasil, esse sistema online foi implantado em 2013, em todas as Unidades da Federação. Além da TBDR, no SITE-TB são registradas pessoas com tuberculose sensível com indicação de esquema especial, e aquelas com micobacterioses não tuberculosas identificadas por diagnóstico diferencial de tuberculose. Toda pessoa com tuberculose confirmada deve ser notificada no Sistema de Informação de Agravos de Notificação (Sinan). Em situações nas quais se faz necessário tratamento com esquema especial, o caso é encerrado no Sinan e notificado no SITE-TB. Profissionais das unidades de referência para tuberculose fazem a notificação e acompanhamento desses casos no sistema, assim como a gestão dos medicamentos.

Abstract The Special Tuberculosis Treatment Information System (SITE-TB) arose mainly from the need to routinely monitor all persons with drug-resistant tuberculosis (DR-TB) in Brazil, as well as to qualify tuberculosis’ drug control. Developed by the Professor Hélio Fraga Reference Center and the Management Sciences for Health/Brazil Project, this online system was implemented in 2013 in all Brazilian states. In addition to DR-TB, the system registers people with drug-sensitive tuberculosis with special regimen indications, and those with nontuberculous mycobacterial infections identified by differential diagnosis of tuberculosis. All confirmed tuberculosis cases should be notified on the Notifiable Diseases Information System (SINAN). In situations where treatment with special regimens is necessary, the case is closed on SINAN and notified on SITE-TB. Professionals from tuberculosis reference centers report and monitor these cases on the system, as well as manage tuberculosis’ drugs.

Resumen El Sistema de Información de Tratamientos Especiales de Tuberculosis (SITE-TB) surgió principalmente de la necesidad de monitorear rutinariamente todas las personas con tuberculosis drogorresistente (TB-DR) en Brasil y cualificar el control de drogas antituberculosis. Desarrollado por el Centro de Referencia Profesor Hélio Fraga y el proyecto Management Sciences for Health/Brasil, este sistema online fue implantado en 2013 en todos los estados del país. Además de TB-DR, el SITE-TB registra personas con tuberculosis sensible con indicación de régimen especial, y aquellas con micobacteriosis no tuberculosas identificadas por diagnóstico diferencial de tuberculosis. Toda persona con tuberculosis confirmada debe ser notificada en el Sistema de Información de Agravamientos de Notificación (SINAN). Para situaciones en las que se hace necesario tratamiento con régimen especial, el caso se cierra en el SINAN y se notifica en el SITE-TB. Los profesionales de las unidades de referencia para TB son los que hacen la notificación y seguimiento de estos casos en el sistema, así como la gestión de las drogas antituberculosis.

https://doi.org/10.5123/s1679-49742019000200002

Sistema de Informação de Tratamentos Especiais de Tuberculose (SITE-TB): histórico, descrição e perspectivas
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Bartholomay, Patricia

; Pinheiro, Rejane Sobrino

; Pelissari, Daniele Maria

; Arakaki-Sanchez, Denise

; Dockhorn, Fernanda

; Rocha, Jorge Luiz

; Penna, Estefania Quilma Andrade de Araújo

; Barreira, Draurio

; Araújo, Wildo Navegantes de

; Dalcolmo, Margareth

Epidemiologia e Serviços de Saúde

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2019, Volume 28 N. 2 elocation e2018158

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.5123/s1679-49742019000200002

Predictors of mortality in multidrug-resistant tuberculosis patients from Brazilian reference centers, 2005 to 2012
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Gayoso, Regina

; Dalcolmo, Margareth

; Braga, José Ueleres

; Barreira, Draurio

Brazilian Journal of Infectious Diseases

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aug 2018, Volume 22 N. 4 Pages 305 - 310

Abstract: En | Text: En | PDF: En

ABSTRACT Objectives To determine the main predictors of death in multidrug-resistant (MDRTB) patients from Brazil. Design Retrospective cohort study, a survival analysis of patients treated between 2005 and 2012. Results Of 3802 individuals included in study, 64.7% were men, mean age was 39 (1-93) years, and 70.3% had bilateral pulmonary disease. Prevalence of human immunodeficiency virus (HIV) was 8.3%. There were 479 (12.6%) deaths. Median survival time was 1452 days (4 years). Factors associated with increased risk of death were age greater than or equal to 60 years (hazard rate [HR] = 1.6, confidence interval [CI] = 1.15-2.2), HIV co-infection (HR = 1.46; CI = 1.05-1.96), XDR resistance pattern (HR = 1.74, CI = 1.05-2.9), beginning of treatment after failure (HR = 1.72, CI = 1.27-2.32), drug abuse (HR = 1.64, CI = 1.22-2.2), resistance to ethambutol (HR = 1.30, CI = 1.06-1.6) or streptomycin (HR = 1.24, CI = 1.01-1.51). Mainly protective factors were presence of only pulmonary disease (HR = 0.57, CI = 0.35-0.92), moxifloxacin use (HR = 0.44, CI = 0.25-0.80), and levofloxacin use (HR = 0.75; CI = 0.60-0.94). Conclusion A more comprehensive approach is needed to manage MDRTB, addressing early diagnostic, improving adhesion, and comorbidities, mainly HIV infection and drug abuse. The latest generation quinolones have an important effect in improving survival in MDRTB.

https://doi.org/10.1016/j.bjid.2018.07.002 1033 downloads

Cadastro Nacional de Estabelecimentos de Saúde como ferramenta de análise da descentralização do atendimento da tuberculose para a atenção básica
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Pelissari, Daniele Maria

; Jacobs, Marina Gasino

; Bartholomay, Patricia

; Rocha, Marli Souza

; Barreira, Draurio

; Arakaki-Sanchez, Denise

; Toledo, João Paulo

; Diaz-Quijano, Fredi Alexander

Cadernos de Saúde Pública

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2018, Volume 34 N. 12 elocation e00173917

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo: Os objetivos deste artigo foram validar um método de classificação dos serviços de saúde (atenção básica vs. outros níveis) e descrever a descentralização do atendimento da tuberculose (TB) para a atenção básica no Brasil no período de 2002 a 2016. Os serviços de saúde que notificaram e acompanharam pessoas com TB foram classificados como “atenção básica” ou “outros níveis”, considerando-se o tipo de estabelecimento registrado no Cadastro Nacional de Estabelecimentos de Saúde (CNES). Foi estimada a concordância entre essa classificação e uma realizada em 2013 pelos programas estaduais e municipais de TB. Posteriormente, utilizando-se o CNES, calculou-se o percentual de pessoas com TB atendidas na atenção básica no período de 2002 a 2016. A concordância foi de 94,4% e o índice kappa global foi 0,86. Houve um incremento relativo de 31,2% do atendimento de TB na atenção básica (50,9% em 2002 para 66,8% em 2016). Todas as regiões apresentaram aumento desse percentual, exceto a Região Sul. A classificação baseada no CNES permitiu analisar a evolução da descentralização do atendimento da TB para a atenção básica no Brasil.

Abstract: This study aimed to validate a method for classification of healthcare services in Brazil (basic care vs. other levels) and describe the decentralization of tuberculosis (TB) care to basic services (2002 to 2016). The healthcare services that reported and followed TB cases were classified as either “basic care” or “other levels” based on the type of establishment registered in the Brazilian National Registry of Healthcare Establishments (CNES, in Portuguese). The study estimated the agreement between this classification with a previous classification performed in 2013 by Brazil’s state and local tuberculosis programs. Using the CNES registry, the authors then calculated the percentage of TB patients treated in basic care from 2002 to 2016. Agreement was 94.4%, and overall kappa index was 0.86. There was a relative increment of 31.2% in TB care provided by basic services (from 50.9% in 2002 to 66.8% in 2016). All regions of Brazil showed an increase in this percentage, except the South. The classification based on the CNES registry allowed analyzing the trend in decentralization of TB treatment to basic healthcare services in Brazil.

Resumen: Los objetivos de este artículo fueron validar un método de clasificación de los servicios de salud (atención básica vs. otros niveles) y describir la descentralización del cuidado de la tuberculosis (TB) hacia los servicios de atención básica en Brasil, durante el período de 2002 a 2016. Los servicios de salud que notificaron y efectuaron el seguimiento a personas con TB fueron clasificados como “atención básica” u “otros niveles”, considerándose el tipo de establecimiento registrado en el Registro Nacional de Establecimientos de Salud (CNES). Se estimó la concordancia entre esta clasificación y una realizada en 2013 por los programas estatales y municipales de TB. Posteriormente, utilizando el CNES, se calculó el porcentaje de personas con TB atendidas en la atención básica durante el período de 2002 a 2016. La concordancia fue de 94,4% y el índice kappa global fue 0,86. Hubo un incremento relativo de un 31,2% del manejo de la TB en la atención básica (de un 50,9% en 2002 hasta un 66,8% en 2016). Todas las regiones presentaron un aumento de ese porcentaje, excepto la región Sur. La clasificación, basada en el CNES, permitió analizar la evolución de la descentralización del manejo de la TB hacia la atención básica en Brasil.

https://doi.org/10.1590/0102-311x00173917 51 downloads

Cadastro Nacional de Estabelecimentos de Saúde como ferramenta de análise da descentralização do atendimento da tuberculose para a atenção básica
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Pelissari, Daniele Maria

; Jacobs, Marina Gasino

; Bartholomay, Patricia

; Rocha, Marli Souza

; Barreira, Draurio

; Arakaki-Sanchez, Denise

; Toledo, João Paulo

; Diaz-Quijano, Fredi Alexander

Cadernos de Saúde Pública

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2018, Volume 34 N. 12 elocation e00173917

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/0102-311x00173917 1555 downloads

Os desafios para a eliminação da tuberculose no Brasil
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Barreira, Draurio

Epidemiologia e Serviços de Saúde

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2018, Volume 27 N. 1 elocation e00100009

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.5123/s1679-49742018000100009 183 downloads

Os desafios para a eliminação da tuberculose no Brasil
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Barreira, Draurio

Epidemiologia e Serviços de Saúde

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2018, Volume 27 N. 1 elocation e00100009

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.5123/s1679-49742018000100009 16769 downloads

Brazilian Response to Global End TB Strategy : The National Tuberculosis Research Agenda
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Kritski, Afranio

; Barreira, Draurio

; Junqueira-Kipnis, Ana Paula

; Moraes, Milton Ozorio

; Campos, Maria Martha

; Degrave, Wim Mauritz

; Miranda, Silvana Spindola

; Krieger, Marco Aurelio

; Chimara, Erica

; Morel, Carlos

; Dalcolmo, Margareth Pretti

; Maciel, Ethel Leonor Noia

; Evangelista, Maria do Socorro Nantua

; Villa, Teresa Scatena

; Sanchez, Mauro

; Costa, Fernanda Dockhorn

; Queiroz, Inacio

; Oliveira, Martha Maria

; Souza Junior, Ruy

; Silva, Jose Roberto Lapa e

; Ruffino-Netto, Antonio

Revista da Sociedade Brasileira de Medicina Tropical

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feb 2016, Volume 49 N. 1 Pages 135 - 145

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/0037-8682-0330-2015 3881 downloads

10.

Using a single tablet daily to treat latent tuberculosis infection in Brazil: bioequivalence of two different isoniazid formulations (300 mg and 100 mg) demonstrated by a sensitive and rapid high-performance liquid chromatography-tandem mass spectrometry method in a randomised, crossover study
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Daher, André

; Pitta, Luciana

; Santos, Tereza

; Barreira, Draurio

; Pinto, Douglas

Memórias do Instituto Oswaldo Cruz

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jun 2015, Volume 110 N. 4 Pages 543 - 550

Abstract: En | Text: En | PDF: En

The recommended treatment for latent tuberculosis (TB) infection in adults is a daily dose of isoniazid (INH) 300 mg for six months. In Brazil, INH was formulated as 100 mg tablets. The treatment duration and the high pill burden compromised patient adherence to the treatment. The Brazilian National Programme for Tuberculosis requested a new 300 mg INH formulation. The aim of our study was to compare the bioavailability of the new INH 300 mg formulation and three 100 mg tablets of the reference formulation. We conducted a randomised, single dose, open label, two-phase crossover bioequivalence study in 28 healthy human volunteers. The 90% confidence interval for the INH maximum concentration of drug observed in plasma and area under the plasma concentration vs. time curve from time zero to the last measurable concentration “time t” was 89.61-115.92 and 94.82-119.44, respectively. The main limitation of our study was that neither adherence nor the safety profile of multiple doses was evaluated. To determine the level of INH in human plasma, we developed and validated a sensitive, simple and rapid high-performance liquid chromatography-tandem mass spectrometry method. Our results showed that the new formulation was bioequivalent to the 100 mg reference product. This finding supports the use of a single 300 mg tablet daily strategy to treat latent TB. This new formulation may increase patients’ adherence to the treatment and quality of life.

https://doi.org/10.1590/0074-02760140458 1911 downloads

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Tuberculosis in BRICS: challenges and opportunities for leadership within the post-2015 agenda
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Creswell, Jacob

; Sahu, Suvanand

; Sachdeva, Kuldeep Singh

; Ditiu, Lucica

; Barreira, Draurio

; Mariandyshev, Andrei

; Mingting, Chen

; Pillay, Yogan

Bulletin of the World Health Organization

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jun 2014, Volume 92 N. 6 Pages 459 - 460

Abstract: En | Text: En | PDF: En

https://doi.org/10.2471/BLT.13.133116 1009 downloads Cited 1 time in SciELO

12.

Tuberculosis in Brazil: last ten years analysis - 2001-2010
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Oliveira, Gisele Pinto de

; Torrens, Ana Wieczorek

; Bartholomay, Patrícia

; Barreira, Draurio

Brazilian Journal of Infectious Diseases

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apr 2013, Volume 17 N. 2 Pages 218 - 233

Abstract: En | Text: En | PDF: En

OBJECTIVE: To describe tuberculosis epidemiological situation in Brazil, as well as program performance indicators in 2001-2010 period, and discuss the relationship between changes observed and control measures implemented in this century first decade. METHODS: It is a descriptive study, data source was the Information System for Notifiable Diseases (Sinan), Mortality Information System (SIM), Unified Health System Hospital Information System (SIH/SUS) and TB Multidrug-resistant Surveillance System (MDR-TB/SS). Indicators analyzed were organized into four major groups: TB control program (TCP) coverage and case detection; morbidity; treatment and TCP performance; and mortality. RESULTS: In the years analyzed there was a decrease in the number of new cases and incidence rate, mortality reduction (relative and absolute), and improvement in TB detection and diagnosis, as well in TB/HIV coinfection and drug resistance. However, little progress was found in contact investigation, diagnosis in primary care and TB cure rate. DISCUSSION: Results showed many advances in tuberculosis control in the 10 years analyzed, but it also points to serious obstacles that need to be solved so Brazil can eliminate tuberculosis as a public health problem.

https://doi.org/10.1016/j.bjid.2013.01.005 3213 downloads Cited 14 times in SciELO

13.

Uso do sistema de informação sobre mortalidade para identificar subnotificação de casos de tuberculose no Brasil
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Oliveira, Gisele Pinto de

; Pinheiro, Rejane Sobrino

; Coeli, Cláudia Medina

; Barreira, Draurio

; Codenotti, Stefano Barbosa

Revista Brasileira de Epidemiologia

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sep 2012, Volume 15 N. 3 Pages 468 - 477

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O objetivo desse trabalho foi analisar a subnotificação dos óbitos por tuberculose (TB) no Brasil, assim como verificar o impacto que esses casos causariam na taxa de notificação de casos novos e proporção de óbitos por TB em 2006. Foram analisados os óbitos registrados no Sistema de Informação sobre Mortalidade (SIM) no ano de 2006 e todas as notificações de TB do país no período de 2001 a 2006. As variáveis utilizadas para o relacionamento foram: número da notificação, município e UF de residência, nome do paciente, data, ano de nascimento, sexo, nome da mãe e endereço. Foram realizados seis passos de blocagem. Os escores superiores a 12,4 foram considerados pares, enquanto os inferiores a - 9,7, não-pares. Ao final de cada passo, foi realizada a revisão manual dos pares duvidosos. O Sistema de Informação de Agravos de Notificação (Sinan) dispunha de 547.589 notificações, enquanto o SIM tinha 6.924 registros. Desses, 39,4% (n = 2.727) não foram encontrados no Sinan no período avaliado. Observou-se que 64,5% (2.707) dos óbitos foram notificados em 2006 e, ao analisar a proporção de óbitos subnotificados por região e unidades federadas, verificou-se que o maior percentual foi na região Norte, seguida das regiões Sudeste e Nordeste. O acréscimo dos óbitos que não foram relacionados à base de dados do Sinan eleva a taxa de notificação de casos novos em 3,7%. Quanto à proporção de óbitos por TB, essa inclusão foi responsável pelo aumento em 60,7% desse indicador. O relacionamento entre bases de dados configura-se como uma estratégia importante para a melhoria da qualidade do sistema de vigilância da TB.

The aim of the study was to analyze the underreporting of deaths from tuberculosis (TB) in Brazil, as well as to assess the impact these cases would cause in the reporting rate and proportion of TB deaths in 2006. We ana-lyzed the deaths recorded in the Mortality Information System (SIM) in 2006 and all reports of TB in Brazil during the 2001 to 2006 period. The variables used for the relationship were: report number, city and State of residence, patient name, date and year of birth, sex, mother's name and address. Six blocking steps were performed. Scores above 12.4 were considered pairs, and those below 9.7, doubtful pairs. After each step, we performed a manual review of doubtful pairs. The Reportable Disease Information System (Sinan) had 547,589 records. The SIM had 6,924 records, 39.3% (n = 2,727) of which were not found in Sinan during the period evaluated. We observed that 64.5% (2,707) of deaths were reported in 2006 and after analyzing the proportion of deaths underreported by region and federal units, we found that the highest percentage was in the Northern region, followed by the Southeast and Northeast. The addition of deaths that had not been reported to the Sinan database increased the reporting rate 3.7%. Regarding the proportion of deaths due to TB, such inclusion was responsible for a 60.7% increase in this indicator. The relationship between both databases seems to be an important strategy for improving the quality of the TB surveillance system.

14.

Uso do sistema de informação sobre mortalidade para identificar subnotificação de casos de tuberculose no Brasil
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Oliveira, Gisele Pinto de

; Pinheiro, Rejane Sobrino

; Coeli, Cláudia Medina

; Barreira, Draurio

; Codenotti, Stefano Barbosa

Revista Brasileira de Epidemiologia

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sep 2012, Volume 15 N. 3 Pages 468 - 477

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

3168 downloads Cited 11 times in SciELO

15.

III Diretrizes para Tuberculose da Sociedade Brasileira de Pneumologia e Tisiologia
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Conde, Marcus Barreto

; Melo, Fernando Augusto Fiuza de

; Marques, Ana Maria Campos

; Cardoso, Ninarosa Calzavara

; Pinheiro, Valeria Goes Ferreira

; Dalcin, Paulo de Tarso Roth

; Machado Junior, Almério

; Lemos, Antonio Carlos Moreira

; Netto, Antônio Ruffino

; Durovni, Betina

; Sant'Anna, Clemax Couto

; Lima, Dinalva

; Capone, Domenico

; Barreira, Draurio

; Matos, Eliana Dias

; Mello, Fernanda Carvalho de Queiroz

; David, Fernando Cezar

; Marsico, Giovanni

; Afiune, Jorge Barros

; Silva, José Roberto Lapa e

; Jamal, Leda Fátima

; Telles, Maria Alice da Silva

; Hirata, Mário Hiroyuki

; Dalcolmo, Margareth Pretti

; Rabahi, Marcelo Fouad

; Cailleaux-Cesar, Michelle

; Palaci, Moises

; Morrone, Nelson

; Guerra, Renata Leborato

; Dietze, Reynaldo

; Miranda, Silvana Spíndola de

; Cavalcante, Solange Cesar

; Nogueira, Susie Andries

; Nonato, Tatiana Senna Galvão

; Martire, Terezinha

; Galesi, Vera Maria Nader

; Dettoni, Valdério do Valle

Jornal Brasileiro de Pneumologia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

oct 2009, Volume 35 N. 10 Pages 1018 - 1048

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Diariamente novos artigos científicos sobre tuberculose (TB) são publicados em todo mundo. No entanto, é difícil para o profissional sobrecarregado na rotina de trabalho acompanhar a literatura e discernir o que pode e deve ser aplicado na prática diária juntos aos pacientes com TB. A proposta das "III Diretrizes para TB da Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)" é revisar de forma crítica o que existe de mais recente na literatura científica nacional e internacional sobre TB e apresentar aos profissionais da área de saúde as ferramentas mais atuais e úteis para o enfrentamento da TB no nosso país. As atuais "III Diretrizes para TB da SBPT" foram desenvolvidas pela Comissão de TB da SBPT e pelo Grupo de Trabalho para TB a partir do texto das "II Diretrizes para TB da SBPT" (2004). As bases de dados consultadas foram LILACS (SciELO) e PubMed (Medline). Os artigos citados foram avaliados para determinação do nível de evidência científica, e 24 recomendações sobre TB foram avaliadas, discutidas por todo grupo e colocadas em destaque. A primeira versão das "III Diretrizes para TB da SBPT" foi colocada no website da SBPT para consulta pública durante três semanas, e as sugestões, críticas e o nível de evidência da referência científica que as embasavam foram avaliados e discutidos antes de serem incorporadas ou não ao texto final.

New scientific articles about tuberculosis (TB) are published daily worldwide. However, it is difficult for health care workers, overloaded with work, to stay abreast of the latest research findings and to discern which information can and should be used in their daily practice on assisting TB patients. The purpose of the III Brazilian Thoracic Association (BTA) Guidelines on TB is to critically review the most recent national and international scientific information on TB, presenting an updated text with the most current and useful tools against TB to health care workers in our country. The III BTA Guidelines on TB have been developed by the BTA Committee on TB and the TB Work Group, based on the text of the II BTA Guidelines on TB (2004). We reviewed the following databases: LILACS (SciELO) and PubMed (Medline). The level of evidence of the cited articles was determined, and 24 recommendations on TB have been evaluated, discussed by all of the members of the BTA Committee on TB and of the TB Work Group, and highlighted. The first version of the present Guidelines was posted on the BTA website and was available for public consultation for three weeks. Comments and critiques were evaluated. The level of scientific evidence of each reference was evaluated before its acceptance for use in the final text.

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