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Duplex ultrasound and computed tomography angiography in the follow-up of endovascular abdominal aortic aneurysm repair: a comparative study
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Cantador, Alex Aparecido

; Siqueira, Daniel Emílio Dalledone

; Jacobsen, Octavio Barcellos

; Baracat, Jamal

; Pereira, Ines Minniti Rodrigues

; Menezes, Fábio Hüsemann

; Guillaumon, Ana Terezinha

Radiologia Brasileira

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aug 2016, Volume 49 N. 4 Pages 229 - 233

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Comparar a ultrassonografia duplex e a angiotomografia computadorizada no diagnóstico dos endoleaks e na medida do diâmetro do saco aneurismático no acompanhamento pós-operatório da correção endovascular do aneurisma de aorta abdominal. Materiais e Métodos: Foram estudados, prospectivamente, 30 doentes submetidos a correção endovascular de aneurismas de aorta infrarrenal e ilíacas. No seguimento pós-operatório foram realizadas ultrassonografia duplex e angiotomografia no mesmo intervalo de tempo, por radiologistas independentes. Foram avaliadas as medidas do saco aneurismático e a presença ou ausência de endoleaks . Resultados: O diâmetro médio do saco aneurismático encontrado foi 6,09 ± 1,95 cm para a ultrassonografia duplex e 6,27 ± 2,16 cm para a angiotomografia, existindo correlação estatisticamente significante, com R = 0,88 e p < 0,01 (Pearson). Considerando a detecção de endoleaks , o valor preditivo negativo da ultrassonografia duplex (comparada à angiotomografia) foi 92,59% e a especificidade foi 96,15%. Conclusão: Os resultados demonstram pequena variação entre os métodos empregados, não comprometendo o manejo clínico. A ultrassonografia duplex poderia substituir a angiotomografia no acompanhamento pós-operatório da correção endovascular do aneurisma de aorta infrarrenal, com baixo custo, evitando potenciais complicações clínicas relacionadas ao uso de contraste iodado e exposição à radiação ionizante.

Abstract Objective: To compare duplex ultrasound and computed tomography (CT) angiography in terms of their performance in detecting endoleaks, as well as in determining the diameter of the aneurysm sac, in the postoperative follow-up of endovascular abdominal aortic aneurysm repair. Materials and Methods: This was a prospective study involving 30 patients who had undergone endovascular repair of infrarenal aortoiliac aneurysms. Duplex ultrasound and CT angiography were performed simultaneously by independent radiologists. Measurements of the aneurysm sac diameter were assessed, and the presence or absence of endoleaks was determined. Results: The average diameter of the aneurysm sac, as determined by duplex ultrasound and CT angiography was 6.09 ± 1.95 and 6.27 ± 2.16 cm, respectively. Pearson's correlation coefficient showing a statistically significant correlation (R = 0.88; p < 0.01). Comparing the duplex ultrasound and CT angiography results regarding the detection of endoleaks, we found that the former had a negative predictive value of 92.59% and a specificity of 96.15%. Conclusion: Our results show that there is little variation between the two methods evaluated, and that the choice between the two would have no significant effect on clinical management. Duplex ultrasound could replace CT angiography in the postoperative follow-up of endovascular aneurysm repair of the infrarenal aorta, because it is a low-cost procedure without the potential clinical complications related to the use of iodinated contrast and exposure to radiation.

https://doi.org/10.1590/0100-3984.2014.0139 2899 downloads

p.Q192R SNP of PON1 seems not to be Associated with Carotid Atherosclerosis Risk Factors in an Asymptomatic and Normolipidemic Brazilian Population Sample
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Scherrer, Daniel Zanetti

; Zago, Vanessa Helena de Souza

; Vieira, Isabela Calanca

; Parra, Eliane Soler

; Panzoldo, Natália Baratella

; Alexandre, Fernanda

; Secolin, Rodrigo

; Baracat, Jamal

; Quintão, Eder Carlos Rocha

; Faria, Eliana Cotta de

Arquivos Brasileiros de Cardiologia

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jul 2015, Volume 105 N. 1 Pages 45 - 52

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Fundamentos:Evidências sugerem que a paroxonase 1 (PON1) confere importantes propriedades antioxidantes e antiinflamatórias quando associada à lipoproteína de alta densidade (HDL).Objetivo:Investigar as relações entre o SNP p.Q192R da PON1, parâmetros bioquímicos e aterosclerose carotídea em uma amostra populacional brasileira assintomática e normolipidêmica.Métodos:Foram estudados 584 voluntários (mulheres, n = 326; homens, n = 258; idade entre 19-75 anos). Foi extraído DNA genômico total e o SNP foi detectado na plataforma de genotipagem TaqMan® SNP OpenArray®(Applied Biosystems, Foster City, CA). Foram dosadas lipoproteínas e apolipoproteínas plasmáticas, e a atividade da PON1 foi medida utilizando-se paraoxon como substrato. Foi utilizada ultrassonografia bidimensional de alta resolução para determinar a espessura íntimo‑medial das artérias carótidas (EIMc) e a presença de placas ateroscleróticas carotídeas em um subgrupo de indivíduos (n = 317).Resultados:A presença de p.192Q esteve associada a um aumento significativo da atividade da PON1 (RR = 12,30 (11,38); RQ = 46,96 (22,35); QQ = 85,35 (24.83) μmol/min; p < 0,0001), HDL-C (RR = 45 (37); RQ = 62 (39); QQ= 69 (29) mg/dL; p < 0,001) e apo A-1 (RR = 140,76 ± 36,39; RQ = 147,62 ± 36,92; QQ = 147,49 ± 36,65 mg/dL; p = 0,019). A análise de regressãostepwise mostrou que heterozigotos e portadores de p.192Q influenciaram 58% da atividade da PON1 em relação ao paraoxon. A análise de regressão linear univariada demonstrou que não houve associação entre o SNP p.Q192R e a EIMc média; como resultado, na análise de regressão múltipla nenhuma variável foi selecionada com 5% de significância. Os parâmetros estudados não se associaram à presença de placas carotídeas na análise de regressão logística.Conclusão:Em indivíduos de baixo risco, a presença da variante p.192Q daPON1 mostrou-se associada a um perfil lipídico plasmático benéfico e à ausência de aterosclerose de carótida.

Background:Evidences suggest that paraoxonase 1 (PON1) confers important antioxidant and anti-inflammatory properties when associated with high-density lipoprotein (HDL).Objective:To investigate the relationships between p.Q192R SNP ofPON1, biochemical parameters and carotid atherosclerosis in an asymptomatic, normolipidemic Brazilian population sample.Methods:We studied 584 volunteers (females n = 326, males n = 258; 19-75 years of age). Total genomic DNA was extracted and SNP was detected in the TaqMan® SNP OpenArray® genotyping platform (Applied Biosystems, Foster City, CA). Plasma lipoproteins and apolipoproteins were determined and PON1 activity was measured using paraoxon as a substrate. High-resolution β-mode ultrasonography was used to measure cIMT and the presence of carotid atherosclerotic plaques in a subgroup of individuals (n = 317).Results:The presence of p.192Q was associated with a significant increase in PON1 activity (RR = 12.30 (11.38); RQ = 46.96 (22.35); QQ = 85.35 (24.83) μmol/min; p < 0.0001), HDL-C (RR= 45 (37); RQ = 62 (39); QQ = 69 (29) mg/dL; p < 0.001) and apo A-I (RR = 140.76 ± 36.39; RQ = 147.62 ± 36.92; QQ = 147.49 ± 36.65 mg/dL; p = 0.019). Stepwise regression analysis revealed that heterozygous and p.192Q carriers influenced by 58% PON1 activity towards paraoxon. The univariate linear regression analysis demonstrated that p.Q192R SNP was not associated with mean cIMT; as a result, in the multiple regression analysis, no variables were selected with 5% significance. In logistic regression analysis, the studied parameters were not associated with the presence of carotid plaques.Conclusion:In low-risk individuals, the presence of the p.192Q variant ofPON1 is associated with a beneficial plasma lipid profile but not with carotid atherosclerosis.

https://doi.org/10.5935/abc.20150053 2376 downloads

Parameters of two-dimensional perineal ultrasonography for evaluation of urinary incontinence after Radical Prostatectomy
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Cruz, Danilo Souza Lima da Costa

; D’Ancona, Carlos Arturo Levi

; Baracat, Jamal

; Alves, Marco Antonio Dionisio

; Cartapatti, Marcelo

; Damião, Ronaldo

International braz j urol

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oct 2014, Volume 40 N. 5 Pages 596 - 604

Abstract: En | Text: En | PDF: En

Introduction Urinary incontinence remains a major concern for patients undergoing radical prostatectomy. Its prevalence can reach 20% in the late postoperative period. Materials and Methods This clinical study investigated the differences of a dynamic evaluation of the urethra and pelvic floor contraction using perineal ultrasound in men without prostate surgery and in men submitted to radical prostatectomy with and without stress urinary incontinence. Ninety two male patients were included, which 70% of them underwent radical prostatectomy (RP) for more than one year. Thirty one men with clinically post prostatectomy incontinence were compared by two-dimensional (2D) perineal ultrasound to 34 patients without post prostatectomy incontinence and to 27 men without surgery in two centers in Brazil. Results Our results showed that the continent group presented the urethral angle at rest significantly lower than the prostate group (p = 0.0002). We also observed that the incontinent group showed the displacement of the anterior bladder neck during contraction significantly lower than the continent group (p = 0.008). Conclusions We found that the continent group presented the urethral angle at rest significantly lower than the prostate group. The incontinent group also showed the anterior bladder neck displacement during contraction significantly lower than the continent group. It was more evident when the severe incontinent group and the continent group were compared.

https://doi.org/10.1590/S1677-5538.IBJU.2014.05.03 2302 downloads

Development of a clinical laboratory data base of hyper and hypo alpha lipoproteins in Campinas-SP and neighboring region
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Parra, Eliane Soler

; Zago, Vanessa Helena de Souza

; Panzoldo, Natália Baratella

; Alexandre, Fernanda

; Vendrame, Felipe

; Virginio, Vitor Wilson de Moura

; Vieira, Isabela Calanca

; Rodrigues, Marcelo Scarpari Dutra

; Cassol, Angela de Souza

; D'Alexandri, Fabio

; Castanho, Vera Sylvia

; Nakamura, Rui

; Baracat, Jamal

; Danelon, Mirian Regina Gardin

; Pozeti, Ronise Carla Sass

; Facin, Ana Cândida Coutinho

; Honorio, Hilda Maria da Silva

; Mesquita, Simone de Cássia Dias

; Silva, Marcio Jorge da

; Lot, Marielza Crosgnac Feres

; Nunes, Valéria Sutti

; Leança, Camila Canteiro

; Nakandakare, Edna Regina

; Quintão, Eder Carlos Rocha

; Faria, Eliana Cotta de

Jornal Brasileiro de Patologia e Medicina Laboratorial

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feb 2013, Volume 49 N. 1 Pages 26 - 33

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

INTRODUÇÃO: O desenvolvimento de pesquisa para diagnóstico e prevenção da doença aterosclerótica cardiovascular no Brasil é de grande importância por esta ser a principal causa de morbimortalidade no país. OBJETIVO: Demonstrar as etapas do processo de seleção de voluntários para a construção de um banco de dados clínico-laboratorial de indivíduos hiperalfalipoproteinêmicos (hiper A) - colesterol da lipoproteína de alta densidade (HDL-C) ≥ 68 mg/dl - e hipoalfalipoproteinêmicos (hipo A) - HDL-C < 39 mg/dl. MATERIAL E MÉTODOS: Os voluntários são contatados a partir de resultados de perfis lipídicos de indivíduos atendidos pelo Sistema Único de Saúde (SUS) de Campinas-SP e região e, se selecionados, são convidados para coleta de sangue, exames clínicos e responder a questionários de atividade física e de frequência alimentar. Após essa avaliação, os indivíduos podem ser convocados para nova coleta de sangue e, posteriormente, para a ultrassonografia de carótidas. RESULTADOS: Entre 598.288 perfis lipídicos recebidos das redes públicas, apenas 0,6% e 0,3% compuseram os nossos grupos hiper A e hipo A, com disparidade entre os gêneros. A falta de questionários efetivos (75%), das chamadas não atendidas (60%) e a não inclusão foram os pontos mais difíceis na construção do banco de dados. DISCUSSÃO: A dificuldade de obtenção de voluntários elegíveis também se deve à baixa prevalência de hipo A e hiper A e à alta prevalência de patologias que contribuem para variações não genéticas do HDL-C. CONCLUSÃO: Apesar das dificuldades na criação da base de dados, este estudo gerou várias publicações e, com o desenvolvimento das análises moleculares e da funcionalidade, muitas outras seguirão em curto período, fatos contribuintes para o diagnóstico e o acompanhamento das dislipidemias envolvendo a HDL.

INTRODUCTION: The development of research for diagnosis, prevention and treatment of atherosclerotic cardiovascular disease is of utmost importance due to the fact that it is the main cause of morbidity and mortality in Brazil. OBJECTIVE: To demonstrate the phases of the selection process for candidates with the aim to develop a clinical-laboratorial database of hyper alpha lipoproteinemic patients (hyper A) - high density lipoprotein cholesterol (HDL-C) ≥ 68 mg/dl) and hypo alpha lipoproteinemic patients (hypo A) - HDL-C < 39 mg/dl. MATERIAL AND METHODS: The volunteers were contacted after selection of lipid profiles from individuals treated at the Sistema Único de Saúde (SUS), Campinas-SP and neighboring area. Afterwards, the selected patients went through blood collection, clinical examinations and answered questionnaires on dietary frequency and physical activity. After this preliminary evaluation, some individuals were convened to another blood collection and, subsequently, were submitted to an ultrasonographic exam of the carotid arteries. RESULTS: Only 0.6% and 0.3% from 598,288 lipid profiles were selected for hyper A and hypo A groups, respectively, including gender disparity. Lack of effective questionnaires (75%), missing calls (60%) and non-inclusion were the major hindrances in the construction of this database. DISCUSSION: The difficulties to obtain eligible candidates were also due to the low prevalence of both groups hypo A and hyper A and the high prevalence of pathologies that contribute to non-genetic variations of HDL-C. CONCLUSION: In spite of the obstacles in the development of this database, this study brought about several scientific publications. Furthermore, the development of molecular analyzes and functionality will shortly generate other findings, contributing to the diagnosis and follow-up of HDL dyslipidemias.

2274 downloads Cited 1 time in SciELO

Intravesical protrusion of the prostate as a predictive method of bladder outlet obstruction
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Reis, Leonardo O.

; Barreiro, Guilherme C.

; Baracat, Jamal

; Prudente, Alessandro

; D'Ancona, Carlos A.

International braz j urol

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oct 2008, Volume 34 N. 5 Pages 627 - 637

Abstract: En | Text: En | PDF: En

OBJECTIVE: Pressure-flow study is the gold standard for diagnosis of bladder outlet obstruction (BOO). A prospective study was carried out to compare urodynamic evaluation and measurement of intravesical protrusion of the prostate for diagnosing BOO. MATERIALS AND METHODS: Patients presenting with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia and suspected BOO were prospectively evaluated through conventional urodynamics and classified according to the bladder outlet obstruction index (BOOI). They also underwent abdominal ultrasound measurement of the intravesical prostatic protrusion (IPP) and prostatic volume. The IPP was classified into three stages: grade I under 5 mm; grade II, between 5 and 10 mm; and grade III over 10 mm. RESULTS: Forty-two patients, mean age 64.8 ± 8.5 years were enrolled. Transabdominal ultrasound determined a mean prostatic volume of 45 ± 3.2 mL. Achieved IPP's values were the following: grade I - 12 (28.5%), grade II - 5 - (12%) and grade III - 25 (59.5%). The results of prostate volume differed significantly between obstructed and non-obstructed men (p = 0.033) and for IPP among obstructed, inconclusive and non-obstructed men (p = 0.016). For IPP, the area under ROC curve was 0.758 (95% confidence interval - 0.601 to 0.876), and the cutoff point to indicate BOO was 5 mm with 95 % sensitivity (75.1 - 99.2) and 50 % specificity (28.2 - 71.8). CONCLUSION: IPP and prostatic volume measured through abdominal ultrasound are noninvasive and accessible methods that significantly correlate to urinary BOO, and are useful in the diagnosis of male urinary obstructive problems.

16027 downloads

Estudo de 50 casos por tomografia computadorizada de lesões hipodensas hepáticas fundamentais na infância
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Pereira, Inês Minniti Rodrigues

; Álvares, Beatriz Regina

; Baracat, Jamal

; Martins, Daniel Lahan

; Pereira, Ricardo Minniti Rodrigues

Radiologia Brasileira

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apr 2006, Volume 39 N. 2 Pages 103 - 106

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Relatar os diferentes aspectos tomográficos das lesões hepáticas hipodensas na infância, orientando às diferentes possibilidades diagnósticas. MATERIAIS E MÉTODOS: Foram realizados estudos tomográficos de lesões hipodensas hepáticas previamente diagnosticadas à ultra-sonografia em 50 pacientes pediátricos (0-16 anos). As imagens foram obtidas antes e após a administração de contraste venoso. Os aspectos de imagem foram analisados e correlacionados posteriormente com o diagnóstico anatomopatológico. RESULTADOS: Dos 50 casos estudados, 47 foram confirmados, 30 destes por estudo anatomopatológico. A maioria das lesões era benigna, sendo o hemangioma o mais freqüente (20% dos casos). Tais lesões apresentaram captação homogênea do meio de contraste, principalmente na fase tardia, diferenciando assim das malignas. As lesões malignas mais freqüentes foram as metástases (18%). CONCLUSÃO: O presente estudo constatou que o exame tomográfico, antes e após a administração do contraste venoso, dinâmico e/ou helicoidal, foi de grande valia para a complementação da hipótese diagnóstica nas lesões hipodensas hepáticas na infância, devendo ser rotina após diagnóstico ultra-sonográfico.

OBJECTIVE: To describe the different tomographic findings in hypodense hepatic lesions in children and its differential diagnosis. MATERIALS AND METHODS: Computed tomographic studies were obtained from 50 patients (age range: 0-16 years) with low-density liver lesions previously diagnosed by ultrasound. Images were made before and after administration of intravenous contrast medium. Image findings were analyzed and afterwards correlated with anatomopathological diagnosis. RESULTS: Forty-seven of 50 cases were confirmed, 30 by anatomopathological diagnosis. Most of then were benign lesions, hemangioma in 20%. Such lesions presented a homogeneous contrast absorption, mainly at the delayed phase, differing from malignant lesions. Metastasis was the most frequently found malignant lesion (18%). CONCLUSION: Computed tomographic study is of great value in complementing the diagnosis of hypodense hepatic lesions in children, and must follow ultrasound diagnosis as a routine procedure.

38056 downloads

Aumento da transparência pulmonar na infância: ensaio iconográfico
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Martins, Daniel Lahan

; Pereira, Inês Minniti Rodrigues

; Alvares, Beatriz Regina

; Nanni, Lívio

; Baracat, Jamal

Radiologia Brasileira

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feb 2006, Volume 39 N. 1 Pages 69 - 73

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Assimetrias torácicas representadas pelo aumento da transparência pulmonar são causas importantes de morbidade na população pediátrica. A avaliação dos pacientes afetados freqüentemente requer múltiplas modalidades de imagem para diagnosticar a anomalia e planejar a correção cirúrgica. Os autores analisam e ilustram os aspectos de assimetrias torácicas comuns e raras, com ênfase nas manifestações radiológicas. A aplicabilidade das diversas modalidades de imagem no diagnóstico e tratamento é avaliada. Diagnósticos diferenciais, assim como armadilhas e dificuldades diagnósticas, são incluídas.

Thoracic asymmetries characterized by increased radiolucency of the lungs are important causes of morbidity in infants and children. Evaluation of affected patients frequently requires multiple imaging methods to diagnose the abnormality and to plan the surgical correction. The authors review and illustrate the characteristics of both common and rare thoracic asymmetries with emphasis on the radiological findings. The usefulness of different imaging methods in the diagnosis and treatment of these conditions is evaluated. The differential diagnosis as well the pitfalls and diagnostic difficulties are also discussed.

12953 downloads

Percutaneous cholecystostomy: a nonsurgical therapeutic option for acute cholecystitis in high-risk and critically ill patients
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Dabus, Guilherme de Castro

; Dertkigil, Sérgio San Juan

; Baracat, Jamal

Sao Paulo Medical Journal

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2003, Volume 121 N. 6 Pages 260 - 262

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A colecistostomia percutânea é uma modalidade terapêutica potencialmente importante a ser considerada em pacientes em estado grave com colecistite aguda, que estão sob alto risco ao serem submetidos a laparotomia ou a laparoscopia sob anestesia geral. A colecistostomia pecutânea oferece vantagens neste tipo de paciente por evitar os riscos cirúrgicos da colecistectomia. A colecistostomia percutânea é procedimento seguro, minimamente invasivo e efetivo, com alta taxa de sucesso e com pequeno número de complicações relacionadas ao procedimento. Deve ser considerada não apenas como tratamento temporário da colecistite calculosa, mas também como tratamento definitivo nos casos de colecistite acalculosa.

Percutaneous cholecystostomy offers a potentially important type of therapy for critically ill patients with acute cholecystitis who present high risk when undergoing laparotomy or laparoscopy under general anesthesia. It offers a distinct advantage for these kinds of patients by avoiding the risks of the surgical intervention. Percutaneous cholecystostomy is a safe and effective minimally invasive procedure with a high success rate and low procedure-related complications. It should be considered not only in temporary management of calculous cholecystitis, but also in definitive treatment in cases of acalculous cholecystitis.

11015 downloads Cited 1 time in SciELO

Estudo da circulação retrobulbar e do campo visual após dose única oral de citrato de sildenafil (Viagra®)
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Kurahashi, Alessandra

; Nascimento, Maurício

; Marcondes, Ana Maria

; Macchiaverni Filho, Nelson

; Baracat, Jamal

; Costa, Vital Paulino

Arquivos Brasileiros de Oftalmologia

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aug 2001, Volume 64 N. 4 Pages 341 - 345

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Objetivo: Estudar os efeitos na circulação retrobulbar e no campo visual de uma dose oral única de 100 mg de citrato de sildenafil (Viagra®). Métodos: Um estudo duplo-mascarado e controlado por placebo foi realizado em 10 voluntários do sexo masculino, com idade média de 27,7 + 5,68 anos. O olho direito de cada voluntário foi submetido aos exames de Doppler colorido de órbita e análise de campo visual por meio de perimetria computadorizada (Humphrey, programa 30-2, estratégia "Full Threshold") em 3 ocasiões: "baseline", 1 hora após placebo e 1 hora após 100 mg de sildenafil via oral. No campo visual, analisaram-se o limiar foveal e o "mean deviation" (MD) nas 3 ocasiões. No Doppler colorido, medimos a velocidade sistólica máxima (VSM), a velocidade diastólica final (VDF) e o índice de resistência (IR) da artéria central da retina (ACR) e da artéria oftálmica (AO) nas 3 ocasiões. Resultados: A administração do sildenafil não alterou significativamente o limiar foveal e o "mean deviation" em relação ao "baseline" e ao placebo. Houve um aumento significativo da velocidade sistólica máxima e velocidade diastólica final na artéria oftálmica após a administração do citrato de sildenafil (p<0,001). Não houve alteração significativa dos parâmetros hemodinâmicos na artéria central da retina e no índice de resistência da artéria oftálmica. Conclusões: A administração de 100 mg de citrato de sildenafil promoveu um aumento da velocidade de fluxo sanguíneo na artéria oftálmica de indivíduos normais e não promoveu alteração significativa no limiar foveal e "mean deviation" da campimetria computadorizada.

Purpose: To analyze the effects of 100 mg of sildenafil citrate (Viagra®) on the retrobulbar circulation and visual field. Methods: A double masked, placebo controlled study was conducted in 10 males with a mean age of 27.7 + 5.68 years. The right eye of each volunteer underwent orbital color Doppler imaging and automated perimetry (Humphrey, program 30-2, Full-Threshold Strategy) at 3 occasions: baseline, 1 hour after placebo and 1 hour after 100 mg of sildenafil. The foveal threshold and the mean deviation (MD) were analyzed by automated perimetry on the three occasions. Color Doppler imaging allowed the measurement of the peak systolic velocity (PSV), end diastolic velocity (EDV) and Pourcelot index (PI) in the central retinal artery and ophthalmic artery. Results: The foveal threshold and the mean deviation did not show a significant change following the administration of sildenafil. The ophthalmic artery peak systolic velocity and end diastolic velocity significantly increased after the administration of sildenafil (p<0.001). The hemodynamic parameters in the central retinal artery and the ophthalmic artery PI did not significantly change. Conclusions: Sildefanil citrate increased the blood flow velocities in the ophthalmic artery in normal subjects, with no significant changes in the foveal threshold and mean deviation in the automated perimetry.

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