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Abstract The iAtlantic Project has established an international collaborative strategy to improve mapping and characterization of deep and open ocean ecosystems in understudied regions of the Atlantic and evaluate their health. In December 2022, the first iAtlantic expedition in the South Atlantic set off to map and explore seafloor ecosystems in the Santos Basin slope (200-1,000 m depths) in collaboration with the Petrobras ‘Santos Basin - Regional Characterization Project.’ The 17-day ‘iAtlantic_BR10-Petrobras’ cruise was conducted on board the research vessel NPqHOc Vital de Oliveira (Brazilian Navy) and performed (a) water column structure characterization, (b) seafloor morphology mapping, (c) description of benthic habitats and communities by seafloor imagery and biological/ geological sampling, and (d) ex-situ experiments to assess the functioning of sedimentary ecosystems and their responses to climate-related environmental changes. This study describes the rationale behind the iAtlantic_BR10-Petrobras cruise science plan, reports its sampling strategy and methods, and summarizes its collected data and preliminary results.

https://doi.org/10.1590/2675-2824071.23069jaap

WHAT TACTICAL DEFENSIVE BEHAVIORS WOULD HELP BRAZIL STOP GERMANY IN THE 7 TO 1?
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Silva, Bruno Santos da

; Jaime, Matheus de Oliveira

; Marques, Priscila Garcia

; Costa, Luciane Cristina Arantes da

; Costa, Julio Cesar da

; Teixeira, Dourivaldo

; Rinaldi, Wilson

; Borges, Paulo Henrique

Revista Brasileira de Medicina do Esporte

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aug 2022, Volume 28 N. 4 Pages 342 - 345

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO O objetivo desta pesquisa foi verificar quais comportamentos táticos podem predizer a eficiência defensiva de jogadores de futebol de elite. A amostra foi composta por 533 sequências defensivas de seleções semifinalistas da Copa do Mundo FIFA 2014. Foi construído um instrumento ad-hoc com as variáveis: “zona de recuperação da bola”, “pressão defensiva”, “redução de profundidade”, “tempo defensivo gasto”, “número de corredores ocupados”, “número de faltas cometidas” e “número de faltas sofridas”. As sequências táticas foram analisadas com o software Match Vision Studio Premium. A regressão logística multinomial foi aplicada para predizer as chances de sucesso e fracasso de ações coletivas defensivas (P < 0,05). A recuperação da bola na zona defensiva do campo teve aumento de 19 vezes das chances de finalização de gol em comparação com a zona ofensiva média (OR = 19,39; P < 0,01). Por outro lado, reduzir a profundidade defensiva resultou em diminuição de 71% das chances de fazer um gol (OR = 0,29; P < 0,01). Além disso, cada falta cometida aumentou as chances de falha na fase defensiva (OR = 5,39; P < 0,01). Os times que recuperaram a bola longe dos próprios gols e coordenaram sua última linha defensiva para deixar os atacantes em posição de impedimento tiveram sucesso na recuperação da bola. Nível de Evidência IV; Série de casos.

ABSTRACT The purpose of this research was to verify which tactical behaviors can predict defensive efficiency among elite football players. The sample was composed of 533 defensive sequences from national teams that were semifinalists in the FIFA World Cup 2014. An ad-hoc instrument was built with the variables: “ball recovery zone”, “defensive pressure”, “removing depth”, “defensive time spent”, “number of occupied corridors”, “number of fouls committed”, and “number of times fouled”. The tactical sequences were analyzed using Match Vision Studio Premium software. Multinomial logistic regression was applied to predict the chances of success and failure of collective defensive actions (P < 0.05). Recovering the ball in the defensive zone of the field had a 19-times better chance of goal completion compared to recovering the ball in the middle offensive zone (OR = 19.39; P < 0.01). On the other hand, removing defensive depth resulted in a decrease of 71% in the chances of completing a goal (OR = 0.29; P < 0.01). Moreover, every foul committed increased the chances of failure in the defensive phase (OR = 5.39; P < 0.01). Teams that recovered the ball far from their own goals and coordinated their last defensive line to leave attackers in an offside position had success in getting the ball back. Level of Evidence IV; Case series.

RESUMEN El objetivo de esta investigación fue verificar qué comportamientos tácticos pueden predecir la eficiencia defensiva entre los jugadores de fútbol de élite. La muestra estuvo compuesta por 533 secuencias defensivas de selecciones semifinalistas en la Copa Mundial de la FIFA 2014. Se construyó un instrumento ad-hoc con las variables: “zona de recuperación del balón”, “presión defensiva”, “reducción de profundidad”, “tiempo defensivo empleado”, “número de pasillos ocupados”, “número de faltas cometidas” y “número de faltas sufridas”. Las secuencias tácticas se analizaron utilizando el software Match Vision Studio Premium. Se aplicó la regresión logística multinomial para predecir las posibilidades de éxito y fracaso de las acciones colectivas defensivas (P <0,05). La recuperación del balón en las zonas defensivas del campo representó un aumento de 19 veces las posibilidades de finalización del gol en comparación con la zona ofensiva media (OR = 19,39; P <0,01). Por otro lado, eliminar la profundidad defensiva resultó en una disminución del 71% de las posibilidades de marcar un gol (OR = 0,29; P <0,01). Además, cada falta cometida aumentaba las posibilidades de falla en la fase defensiva (OR = 5,39; P <0,01). Los equipos que recuperaron el balón lejos de sus propios arcos y coordinaron su última línea defensiva para dejar a los atacantes en posición de fuera de juego, tuvieron éxito en la recuperación del balón. Nivel de Evidencia IV; Serie de casos.

https://doi.org/10.1590/1517-8692202228042021_0070

Interdisciplinaridade e práticas pedagógicas: O que dizem os professores
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Souza, Mariana Aranha de

; Salgado, Priscila Aparecida Dias

; Chamon, Edna Maria Querido de Oliveira

; Fazenda, Ivani Catarina Arantes

Revista Portuguesa de Educação

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jun 2022, Volume 35 N. 1 Pages 4 - 25

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

Resumo Este estudo tem como objetivo investigar o que professores do Ensino Fundamental, de uma escola com currículo organizado por projetos, pensam sobre interdisciplinaridade e como organizam suas práticas. De natureza qualitativa, utilizou-se como instrumentos de pesquisa a entrevista semiestruturada, realizada de forma individual com oito professores da escola, indicados pela diretora da escola como referência para um trabalho interdisciplinar, a observação e a análise do Projeto Político-Pedagógico. Os dados obtidos nas entrevistas foram tratados inicialmente pelo software IRaMuTeQ e os resultados foram analisados por meio da análise de conteúdo. A análise desses resultados demonstrou que: (i) a interdisciplinaridade é compreendida como a possibilidade de um ensino que faça sentido para o aluno; (ii) é fundamental um processo de constante formação docente, de reorganização da escola e de ressignificação da relação professor-aluno; e (iii) o trabalho com projetos e o desenvolvimento de níveis de autonomia são elementos importantes para a efetivação de práticas interdisciplinares.

Resumen Este estudio tiene como objetivo investigar qué piensan los docentes de Educación Básica, de una escuela cuyo currículo está organizado por proyectos, sobre la interdisciplinariedad y cómo organizan sus prácticas. De naturaleza cualitativa, utilizó como instrumentos de investigación la entrevista semiestructurada, realizada individualmente con ocho docentes de la escuela, indicados por el director de la escuela como referencia para un trabajo interdisciplinario, la observación y el análisis documental del Proyecto Político-Pedagógico. Los datos obtenidos fueron procesados inicialmente por el software IRaMuTeQ y enviados al análisis de contenido. Los resultados mostraron que: (i) la interdisciplinariedad se entiende como la posibilidad de una enseñanza que tiene sentido para el estudiante; (ii) es fundamental un proceso de formación constante del profesorado, de reorganización de la escuela y de resignificación de la relación profesor-alumno; y (iii) el trabajo con projectos y el desarrollo de niveles de autonomía son elementos importantes para la implementación de prácticas interdisciplinarias.

Abstract This study aims to investigate what elementary school teachers, from a school whose curriculum is organized by projects, think about interdisciplinarity and how they organize their practices. Of a qualitative nature, we used as research instruments the semi-structured interview, conducted individually with eight teachers, appointed by the school principal as a reference for an interdisciplinary work, the observation and the documentary analysis of the Political-Pedagogical Project. Data were initially processed by IRaMuTeQ software and submitted to content analysis. The results showed that: (i) interdisciplinarity is understood as the possibility of teaching that makes sense to the student; (ii) a process of constant teacher training, school reorganization and resignification of the teacher-student relationship is essencial; and (iii) the work with projects and the explicit development of autonomy levels are important elements for the implementation of interdisciplinary practices.

https://doi.org/10.21814/rpe.22479 50 downloads

Autism and Down syndrome: early identification and diagnosis
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Diniz, Natália Lisce Fioravante

; Parlato-Oliveira, Erika

; Pimenta, Priscila Gonçalves Ayres

; Araújo, Liubiana Arantes de

; Valadares, Eugênia Ribeiro

Arquivos de Neuro-Psiquiatria

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jun 2022, Volume 80 N. 6 Pages 620 - 630

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Antecedentes: O diagnóstico de autismo na síndrome de Down é subestimado, sendo necessário entender quais aspectos do fenótipo comportamental estão relacionados à síndrome de Down e quais são do autismo. Objetivo: Revisão Sistemática da Literatura sobre identificação precoce e diagnóstico do Transtorno do Espectro Autista em pacientes com síndrome de Down. Fonte de dados: Busca nas bases BVS, MEDLINE, Cochrane, CINAHL, Scopus, Web of Science e Embase e avaliação pelo PRISMA. Síntese dos dados : De 1.729 artigos avaliados, foram selecionados 15. Apesar de ser bastante estudada, a identificação do transtorno do espectro do autismo na síndrome de Down pode ser difícil devido a compreensão de quais aspectos do fenótipo comportamental estão relacionados à síndrome de Down e quais são do autismo. Nessa revisão foi encontrada variação na prevalência de 12% a 41%. A identificação precoce de risco de autismo na síndrome de Down é pouco estudada mesmo existindo instrumentos de triagem para lactentes. Sobre o diagnóstico do autismo na síndrome de Down foram encontrados diversos instrumentos, mas é necessária abordagem desenvolvimental para um diagnóstico apurado. Conclusões: É destacada a importância de procedimentos de triagem de sinais precoces de risco de autismo ainda no primeiro ano de vida. São para estabelecimento do diagnóstico a escolha de instrumentos para a avaliação do desenvolvimento e cognição, análise dos aspectos qualitativos da interação social, dentre outros. A detecção precoce e o diagnóstico preciso no tempo correto e uma intervenção poderão beneficiar o desenvolvimento, a qualidade de vida e inclusão social.

ABSTRACT Background: The diagnosis of autism spectrum disorder (ASD) in Down syndrome (DS) is underestimated because it is necessary to understand which aspects of the behavioral phenotype are related to DS and which are related to ASD. Objective: To conduct a systematic review of the literature on early identification and diagnosis of ASD in patients with DS. Data source: The VHL, MEDLINE, Cochrane, CINAHL, Scopus, Web of Science and Embase databases were searched and data were evaluated using PRISMA. Data synthesis: Out of 1,729 articles evaluated, 15 were selected. Although well studied, identification of ASD in DS can be difficult because of the need to understand which aspects of the behavioral phenotype are related to Down syndrome and which to autism. In this review, the prevalence of ASD was found to range from 12% to 41%. Early identification of autism risk in individuals with Down syndrome is still poorly studied, even though there are screening instruments for infants. Several instruments for diagnosing autism in individuals with Down syndrome were found, but a developmental approach is fundamental for making a clear diagnosis. Conclusions: Screening procedures are important for detecting early signs of autism risk in the first year of life. Careful evaluation methods are needed to establish the diagnosis, which include choosing appropriate tools for evaluation of development and cognition, and analysis of qualitative aspects of social interaction, among others. It has been indicated in the literature that early detection and timely accurate diagnosis, in association with an intervention, may benefit development, quality of life and social inclusion.

https://doi.org/10.1590/0004-282x-anp-2021-0156

PREVALENCE AND FACTORS ASSOCIATED WITH LATE DIAGNOSIS OF THE HIV INFECTION IN A MUNICIPALITY OF SÃO PAULO
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Antonini, Marcela

; Gerin, Larissa

; Melo, Elizabete Santos

; Pontes, Priscila Silva

; Arantes, Lígia Maria Nascimento

; Ferreira, Glenda Roberta Oliveira Naiff

; Reis, Renata Karina

Texto & Contexto - Enfermagem

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2022, Volume 31 elocation e20200579

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: identificar a prevalência e os fatores associados ao diagnóstico tardio da infecção pelo vírus da imunodeficiência humana (HIV), em um município do interior paulista. Método: estudo epidemiológico, analítico e retrospectivo que analisou os casos de HIV e AIDS notificados pelos serviços de saúde no período de 2015 a 2017 por meio dos dados das notificações do Sistema de Informação de Agravos de Notificação (Sinan Net) dos usuários recém-diagnosticados para a infecção pelo HIV/AIDS no município de Ribeirão Preto/SP, Brasil. A coleta de dados ocorreu em maio de 2018. Foi realizado o teste qui-quadrado e regressão logística binária, no qual a variável dependente foi o critério de AIDS no momento da notificação da infecção pelo HIV. Foi considerado o valor de p<0,05 para a associação entre as variáveis estudadas com relação ao diagnóstico tardio. Resultados: dentre os 829 (100%) casos novos de HIV, 290 (35,0%) foram diagnosticados na condição de AIDS. A maioria da população pertencia ao sexo masculino e na faixa etária dos 15 aos 34 anos. A candidose oral e a perda de peso acima de 10% foram os principais sintomas associados à AIDS. Observou-se que pessoas com menor escolaridade e com o aumento da idade eram mais propensas a serem diagnosticadas tardiamente. Conclusão: estratégias que favoreçam o diagnóstico oportuno no município estudado são necessárias, particularmente entre os indivíduos com idade acima de 45 anos e com menor escolaridade.

ABSTRACT Objective: to identify the prevalence and factors associated with late diagnosis of the infection by the Human Immunodeficiency Virus (HIV), in a municipality of São Paulo. Method: an epidemiological, analytical and retrospective study that analyzed the HIV and AIDS cases notified by the health services in the period from 2015 to 2017 using data from the notifications of the Information System for Notifiable Diseases (SINAN Net) corresponding to the users recently diagnosed with HIV/AIDS infection in the municipality of Ribeirão Preto/SP, Brazil. Data collection was in May 2018. The chi-square test was performed, as well as binary logistic regression, where the dependent variable was the AIDS criterion at the moment of notifying infection by HIV. A p-value<0.05 was considered for the association between the variables studied in relation to late diagnosis. Results: of the 829 (100%) new HIV cases, 290 (35.0%) were diagnosed in the condition of AIDS. Most of the population was male and aged between 15 and 34 years old. Oral candidiasis and weight loss greater than 10% were the main symptoms associated with AIDS. It was observed that people with lower schooling levels and older were more prone to late diagnoses. Conclusion: it is necessary to devise strategies that favor timely diagnosis in the municipality under study, particularly among the individuals aged over 45 years old and with lower schooling levels.

RESUMEN Objetivo: identificar la prevalencia y los factores asociados al diagnóstico tardío de la infección ocasionada por el Virus de Inmunodeficiencia Humana (HIV) en un municipio del interior de Brasil. Método: estudio epidemiológico, analítico y retrospectivo que analizó los casos de VIH y SIDA notificados por los servicios de salud entre 2015 y 2017 por medio de los datos de las notificaciones del Sistema de Información de Problemas de Salud pasibles de Notificación (SINAN Net) referentes a los usuarios recién diagnosticados con la infección ocasionada por el VIH/SIDA en el municipio de Ribeirão Preto/SP, Brasil. La recolección de datos fue en mayo de 2018. Se realizaron tanto una prueba de chi-cuadrado como un análisis de regresión logística binaria, en la cual la variable dependiente fue el criterio de SIDA al momento de notificar la infección ocasionada por el HIV. Se consideró un valor de p<0,05 para la asociación entre las variables estudiadas en relación con el diagnóstico tardío. Resultados: entre los 829 (100%) casos nuevos de HIV, 290 (35,0%) fueron diagnosticados en la condición de SIDA. La mayoría de la población era del sexo masculino y pertenecía al grupo etario de 15 a 34 años. Candidiasis oral y pérdida de peso superior al 10% fueron los principales síntomas asociados al SIDA. Se observó que las personas con niveles de educación más bajos y de mayor edad fueron más propensas a ser diagnosticadas tardíamente. Conclusión: es necesario elaborar estrategias que favorezcan el diagnóstico oportuno en el municipio estudiado, particularmente entre las personas de más de 45 años de edad y con niveles de educación más bajos.

https://doi.org/10.1590/1980-265x-tce-2020-0579

Diretivas antecipadas de vontade em pacientes com doença de Alzheimer
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Dadalto, Luciana

; Arantes, Alexandra Mendes Barreto

; Baruffi, Priscila Demari

Revista Bioética

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jul 2021, Volume 29 N. 3 Pages 466 - 474

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Em todo o mundo a população idosa tem crescido e, juntamente com o envelhecimento populacional, nota-se o aumento da incidência de demências. Sob a ótica da importância dos instrumentos de manifestação de vontade, e mais especificamente das diretivas para demências, este artigo analisa fatores que contribuem com a perda de autonomia dos idosos acometidos pela doença de Alzheimer em sua fase mais avançada. Para que possa esclarecer seus desejos, é necessário que o idoso estabeleça diretivas preferencialmente na fase inicial da doença, ou seja, enquanto tem capacidade de decidir por si, manifestando suas opiniões e preferências. Conclui-se, no entanto, que ainda é preciso mais debates para que esse instrumento seja usado da melhor forma possível, garantindo a autodeterminação dos pacientes.

Abstract The older population is experiencing worldwide growth, and together with population aging the incidence of dementia is also increasing. This article examines the contributing factors to the loss of autonomy of older people affected by Alzheimer’s disease in its most advanced stage based on the importance of instruments for expression of will, especially the advance directive for dementia. In order for older people with Alzheimer’s disease to clarify their wishes, they need to prepare their directives preferably in the early stages of the disease, that is, when they still have the capacity to make autonomous decisions, expressing their values and preferences. However, further discussions on this issue are necessary for these instruments to be better used in the Brazilian context, and thus ensure the patients’ self-determination.

Resumen En todo el mundo, la población de adultos mayores ha crecido y, junto con el envejecimiento de la población, la incidencia de la demencia ha aumentado. Desde la perspectiva de la importancia de los instrumentos de manifestación de Voluntad, y más específicamente de las directivas para las demencias, este artículo analiza factores que contribuyen a la pérdida de autonomía de los adultos mayores afectados por la enfermedad de Alzheimer en su etapa más avanzada. Para que él pueda aclarar sus deseos, es necesario que el adulto mayor establezca directrices preferiblemente en la etapa inicial de la enfermedad, es decir, mientras tenga la capacidad de decidir por sí mismo, expresando sus opiniones y preferencias. Se concluye, sin embargo, que aún se necesitan más debates para que este instrumento sea utilizado de la mejor manera posible, asegurando la autodeterminación de los pacientes.

https://doi.org/10.1590/1983-80422021293482 161 downloads

Carotid Intima and Media Thickness Correlation with Central Blood Pressure Measurements by Tonometric and Oscillometric Methods: A Proof of Concept
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Barroso, Weimar Kunz Sebba

; Melo, Milena de Andrade

; Vitorino, Priscila Valverde

; Gonçalves, Claudia

; Berigó, João Alexandre

; Arantes, Ana Carolina

; Rezende, Jeeziane

; Jardim, Thiago Veiga

; Souza, Ana Luiza Lima

; Jardim, Paulo César Veiga

International Journal of Cardiovascular Sciences

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feb 2021, Volume 34 N. 1 Pages 22 - 29

Abstract: En | Text: En | PDF: En

Abstract Background The early detection of vascular damage in subclinical stages of hypertensive disease may be the key point in the prevention of cardiovascular outcomes. Objectives to correlate parameters of structural vascular damage (measurement of the carotid intima-media thickness) with parameters of functional vascular damage (central hemodynamic measurements) in pre-hypertensive and hypertensive patients taking up to two classes of anti-hypertensive drugs. Methods This was a cross-sectional descriptive study conducted with a convenience sample of patients attending the Liga de Hipertensão Arterial , a multidisciplinary program for the diagnosis and treatment of systemic hypertension, of the Federal university of Goias. Patients with arrythmia, diabetes, previous cardiovascular or cerebrovascular diseases, and end-stage diseases were excluded. Carotid Doppler test, measurements of peripheral and central blood pressure by applanation tonometry (Sphygmocor®) and oscillometry (Mobil-O-Graph®) were performed. The t-test was used for comparisons and the Pearson correlation test for correlations, considering a p<0.05 statistically significant. Results twenty patients (12 women) were evaluated, mean age 53.8 ± 14.3 years. Higher values of central pulse pressure (42.9±13.9 vs. 34.7±9.6, p=0.01) and pulse wave velocity (PWV) (9.0±1.9 vs. 7.9±1.5, p=0.01) were obtained by applanation tonometry compared with oscillometry. No difference between the methods was observed for the other measures. A significant correlation was found between carotid artery intima-media thickness (CA-IMT) and PWV (r=0.659; p=0.002) by the oscillometric test, but not with applanation tonometry. No correlation was found between central hemodynamic variables and the presence of carotid artery plaques. Conclusion PWV, estimated by oscillometry, was the only central hemodynamic parameter that correlated significantly with CA-IMT in pre-hypertensive and hypertensive patients at low cardiovascular risk. International Journal of Cardiovascular Sciences. 2020; [online].ahead print, PP.0-0

https://doi.org/10.36660/ijcs.20190117 288 downloads

Função Diastólica e Biomarcadores de Participantes de Caminhada de Longa Distância
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Euzebio, Maicon Borges

; Vitorino, Priscila Valverde de O.

; Sousa, Watila Moura

; Melo, Milena Andrade

; Costa, Sérgio Henrique Nascente

; Sousa, Ana Luiza Lima

; Jardim, Thiago de Souza Veiga

; Arantes, Ana Carolina

; Jardim, Paulo Cesar B. Veiga

; Barroso, Weimar Kunz Sebba

Arquivos Brasileiros de Cardiologia

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oct 2020, Volume 115 N. 4 Pages 620 - 627

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento: Os efeitos da caminhada de longa distância sobre o sistema cardiovascular são pouco estudados. Objetivos: O objetivo geral deste estudo foi verificar esses efeitos sobre o comportamento da função diastólica e dos biomarcadores cardíacos CK-MB (massa), troponina T e NT-proBNP em atletas amadores. Método: Este estudo longitudinal realizado em 2015 avaliou os participantes nas 5 etapas seguintes: A0 (basal) antes de iniciar o percurso, e as demais, A1, A2, A3 e A4 ao final de cada dia, totalizando 244,7 km. Em todas as etapas foram dosados os biomarcadores NT-proBNP, CK-MB (massa) e troponina T. Realizou-se ecocardiograma para análise das ondas E, A e E'. Adotado p < 0,05 como significativo. Resultados: Foram avaliados 25 participantes com média de idade de 46 ± 10,5 anos e índice de massa corporal de 20,2 ± 2,3 kg/m2. Encontrou-se aumentos dos valores de NT-proBNP de A0 para A1, A2, A3 e A4 (p < 0,001), CK-MB (massa) de A0 para A2 (p < 0,001) e da onda E' de A0 para A1, A2, A3 e A4 (p < 0,001). Foram identificadas correlações entre os seguintes: CK-MB (massa) e troponina T (A1: r = 0,524, p = 0,010; A4: r = 0,413, p = 0,044); CK-MB (massa) e NT-proBNP (A4: r = 0,539, p = 0,006); e E/A e E' (A0: r = 0,603, p < 0,001; A1: r = 0,639, p < 0,001; A4: r = 0,593, p = 0,002); e correlação negativa entre CK-MB (massa) com E/A (A1: r = −0,428, p = 0,041). Conclusão: Os efeitos da atividade física intensa, prolongada e intercalada foram verificados a partir das variações significativas no comportamento da CK-MB (massa), NT-proBNP e E'. Apesar das alterações encontradas, não houve critérios sugestivos de dano ao miocárdio.

Abstract Background: The effects of long-distance walking on the cardiovascular system have been little studied. Objectives: The general objective of this study was to verify these effects on the behavior of diastolic function and the cardiac biomarkers CK-MB (mass), troponin T, and NT-proBNP, in amateur athletes. Method: This longitudinal study, conducted in 2015, evaluated participants during the following 5 stages: E0 (baseline) before starting the trajectory and the others, E1, E2, E3, and E4, at the end of each day, totaling 244.7 km. At all stages, the biomarkers NT-proBNP, CK-MB (mass), and troponin T were measured. Echocardiogram was performed to analyze the E, A and E' waves. P < 0.05 was adopted as significant. Results: The study evaluated 25 participants, with an average age of 46 ± 10.5 years and body mass index of 20.2 ± 2.3 kg/m2. Increased values were found for NT-proBNP from E0 to E1, E2, E3, and E4 (p < 0.001), CK-MB (mass) from E0 to E2 (p < 0.001), and E' wave from E0 to E1, E2, E3, and E4 (p < 0.001). Positive correlations were identified between the following: CK-MB (mass) and troponin T (E1: r = 0.524, p = 0.010; E4: r = 0.413, p = 0.044); CK-MB (mass) and NT-proBNP (E4: r = 0.539, p = 0.006); and E/A and E' (E0: r = 0.603, p < 0.001; E1: r = 0.639, p < 0.001; E4: r = 0.593, p = 0.002). A negative correlation was found between CK-MB (mass) and E/A (E1: r = −0.428, p = 0.041). Conclusion: The effects of intense, prolonged, and interspersed physical activity were verified based on significant variations in the behavior of CK-MB (mass), NT-proBNP, and the E' wave. Notwithstanding the alterations found, there were no criteria suggestive of myocardial damage

https://doi.org/10.36660/abc.20190271 673 downloads

Tonometric and Oscillometric Methods for Measurement of Central Blood Pressure Parameters: a Comparison in Patients with Borderline Hypertension or Stage 1 Hypertension
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Barroso, Weimar Kunz Sebba

; Gonçalves, Claudia Ferreira

; Berigó, João Alexandre Costa

; Melo, Milena Andrade

; Arantes, Ana Carolina

; Lelis, Ellen De Souza

; Sousa, Watila Moura

; Rezende, Jeeziane Marcelino

; Jardim, Thiago

; Jardim, Paulo Cesar

; Sousa, Ana Luiza Lima

; Vitorino, Priscila Valverde Oliveira

International Journal of Cardiovascular Sciences

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apr 2020, Volume 33 N. 2 Pages 145 - 150

Abstract: En | Text: En | PDF: En

Abstract Background Changes in arterial compliance are among the first changes detectable in hypertensive syndrome. Methods with good reproducibility as compared with the gold standard for identifying such changes are desirable in clinical practice. Objectives To compare central pressure measurements and arterial stiffness obtained by two non-invasive methods (tonometry and oscillometry). Methods This was a descriptive, cross-sectional study with a convenience sample of patients with borderline hypertension or stage 1 hypertension. Peripheral and central blood pressure measurements were obtained by tonometry (SphygmoCor®), considered the gold standard, and oscillometry (Mobil O´graph®). Comparisons of results were made by unpaired t-test, and p values < 0.05 were considered statistically significant. Results No difference was found in central pressure measurements obtained by SphygmoCor® (117 x 80.1 mmHg) compared with Mobil O’graph (112 x 81.4 mmHg). Mean augmentation index (AIx) was 26.1% and 21.3%, and mean pulse pressure (PP) amplification 10.7 mmHg and 10.0 mmHg by Sphygmocor® and Mobil O´graph®, respectively (p > 0.05). Mean pressure wave velocity (PWV), 8.4 m/s vs. 7.4 m/s (p = 0.013) and mean central pulse pressure, 37.7 mmmHg and 30.9 mmHg (p = 0.013) were significantly higher by SphygmoCor® than Mobil O´graph®. Conclusion Values of central systolic blood pressure, AIx and pulse pressure amplification obtained by oscillometry were not statistically different compared with tonometry; values of PWV and cPP, however, were underestimated by oscillometry. (Int J Cardiovasc Sci. 2020; 33(2):145-150)

https://doi.org/10.36660/ijcs.20190020 647 downloads

10.

Efeito da Redução do Sal de Adição sobre a Pressão Arterial Central e Periférica
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Arantes, Ana Carolina

; Sousa, Ana Luiza Lima

; Vitorino, Priscila Valverde de O.

; Jardim, Paulo Cesar B. Veiga

; Jardim, Thiago de Souza Veiga

; Rezende, Jeeziane Marcelino

; Lelis, Ellen de Souza

; Rodrigues, Rafaela Bernardes

; Coca, Antonio

; Barroso, Weimar Kunz Sebba

Arquivos Brasileiros de Cardiologia

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mar 2020, Volume 114 N. 3 Pages 554 - 561

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento Os efeitos da redução na ingestão do sal sobre a pressão arterial (PA) casual de hipertensos já foram amplamente estudados, entretanto essa análise ainda é escassa no contexto da redução exclusiva do sal de adição na rigidez arterial e em indivíduos normotensos e pré-hipertensos. Objetivo Avaliar os efeitos da redução progressiva na ingestão do sal de adição (de 6 para 4 g/dia) sobre os valores da pressão periférica e central, a rigidez arterial em normotensos, pré-hipertensos e hipertensos. Métodos Ensaio clínico, simples cego com 13 semanas de seguimento. Foram avaliados normotensos (≤130/85 mmHg), pré-hipertensos (≥130 e <139/≥85 e <90 mmHg) e hipertensos estágio 1 (≥140 e <160/≥90 e <100 mmHg). Utilizou-se medida casual e monitorização residencial da PA com aparelho automático OMRON 705CP, medida central da PA com Sphygmocor®, dosagem do sódio urinário de 24h (colhido no intervalo entre cada visita) e mensuração de sal de adição. Foi adotado nível de significância p<0,05 para todas as análises. Resultados Foram avaliados 55 participantes (18 normotensos; 15 pré-hipertensos; 22 hipertensos) com mediana 48 anos (IQ:39-54). Os grupos foram semelhantes em relação a idade e sexo. Não houve diferença entre medidas de PA e excreção de sódio antes e depois da intervenção. Os parâmetros de rigidez arterial também não sofreram alterações significativas. Conclusão A redução gradativa da ingestão de sal de adição num seguimento de 13 semanas não foi capaz de reduzir de maneira significativa os valores periféricos e centrais da PA. (Arq Bras Cardiol. 2020; 114(3):554-561)

Abstract Background Although the effects of salt intake reduction on casual blood pressure have been extensively studied in hypertensive individuals, data on reductions of added salt on arterial stiffness in both normotensive and prehypertensive subjects are scarce. Objective To evaluate the effects of progressive reduction in added salt intake (from 6 grams to 4 grams per day) on peripheral and central blood pressure and arterial stiffness in normotensive, prehypertensive and hypertensive individuals. Methods This was a single-blinded clinical trial with 13 weeks of follow-up. Normotensive (≤ 130/85 mmHg), prehypertensive (≥ 130 e < 139/≥ 85 e < 90 mmHg) and stage 1 hypertensive individuals (< 139/≥ 85 and < 90 mmHg) were assessed. Casual blood pressure measurements and ambulatory blood pressure monitoring were performed using the automated OMRON 705CP device, and central blood pressure was measured using the Sphygmocor®. Twenty-four-hour urinary sodium excretion and the amounts of added salt consumed were measured. Statistically significance level was set at p < 0.05 for all analysis. Results A total of 55 participants (18 normotensive, 15 prehypertensive and 22 hypertensive), median age 48 years (IQR:39-54) were studied. The groups were not different in age or sex. No difference was observed in blood pressure or sodium excretion levels before and after the intervention. No significant changes in arterial stiffness parameters were observed. Conclusion The progressive reduction in added salt intake during a period of 13 weeks did not cause significant reductions in peripheral and central blood pressure. (Arq Bras Cardiol. 2020; 114(3):554-561)

https://doi.org/10.36660/abc.20180426 2351 downloads

11.

Configurações do mundo do trabalho e o processo saúde-doença dos trabalhadores docentes de enfermagem
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D'Oliveira, Camila Arantes Ferreira Brecht

; Souza, Norma Valeria Dantas de Oliveira

; Varella, Thereza Christina Mó y Mó Loureiro

; Almeida, Priscila Francisca

Revista Enfermagem UERJ

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2020, Volume 28 elocation e33123

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Objective to analyze the repercussions of teaching work on the health of nursing professors. Method qualitative and descriptive study with 27 teachers from two federal public universities in Rio de Janeiro. The data collection took place through a semi-structured interview and the technique used for the data treatment was the thematic content analysis. Results due to the new configurations of the teaching work, which presses for high labor demand and, in turn, offers inadequate working conditions, this profession favors the teaching sickness, which, on the other hand, relegate health care to the background. Conclusion commitments required on a daily basis and lack of quality in the work make the life of the teacher increasingly removed from their self-care and with high potential for illness.

RESUMEN Objetivo analizar las repercusiones del trabajo docente en la salud de los profesores de enfermería. Método estudio cualitativo y descriptivo realizado con 27 maestros de dos universidades públicas federales de Río de Janeiro. La recolección de datos ocurrió por medio de entrevista semiestructurada y la técnica utilizada para el tratamiento de los datos fue el análisis temático de contenido. Resultados debido a las nuevas configuraciones del trabajo docente, que presiona por alta demanda laboral y, a su vez, ofrece inadecuadas condiciones de trabajo, esta profesión favorece al enfermo docente, que en contrapartida, relegan a segundo plano el cuidado con la propia salud. Conclusión compromisos exigidos en el día a día y la falta de calidad en el trabajo hacen la vida del docente cada vez más alejada de su autocuidado y con elevado potencial para la enfermedad.

RESUMO Objetivo analisar as repercussões do trabalho docente na saúde dos professores de enfermagem. Método estudo qualitativo e descritivo realizado com 27 docentes de duas universidades públicas federais do Rio de Janeiro. A coleta de dados ocorreu por meio de entrevista semiestruturada e a técnica utilizada para o tratamento dos dados foi a análise temática de conteúdo. Resultados devido às novas configurações do trabalho docente, que pressiona por alta demanda laboral e, por sua vez, oferece inadequadas condições de trabalho, esta atividade favorece ao adoecimento desses profissionais, que em contrapartida, relegam a segundo plano o cuidado com a própria saúde. Conclusão compromissos exigidos no dia a dia e a falta de qualidade no trabalho tornam a vida do docente cada vez mais afastada do seu autocuidado e com elevado potencial para o adoecimento.

https://doi.org/10.12957/reuerj.2020.33123 49 downloads

12.

Assessment of Microbial Contamination in Products of Animal Origin: Stretched-curd Cheese, Yogurt and Fresh Sausage
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Mendes, Denise Maria de Souza

; Bastos, Bruno Vinícius

; Koki, Cassia Ribeiro

; Bach, Daniele

; Contini, Gisele Kirchbaner

; Mattos, Lorena Alves de

; Cubo, Mateus Flórido

; Wosiack, Priscila Arcoverde

; Silva, Rafaela Gomes da

; Barboza, Raíssa Arantes

; Valério, Taynara Pacheco

; Lacerda, Luiz Gustavo

; Esmerino, Luís Antônio

; Nogueira, Alessandro

Brazilian Archives of Biology and Technology

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2020, Volume 63 elocation e20190759

Abstract: En | Text: En | PDF: En

Abstract Animal products are sources of microbiological contamination when the process has hygienic-sanitary control fails. Therefore, this work aims the evaluation of the pathogenic microorganisms presented in samples from the Brazil southern region of yogurt (N = 101), stretched curd cheese (N = 31), fresh sausage (N = 22) and processing water (N = 63). Analyses of coliforms at 45 °C, Staphylococcus aureus, Salmonella sp. and Escherichia coli were performed. Analysis indicated processing water is an important contamination source to be monitored, because the majority of samples presented results above the regulation limits. Thermal treatment and fermentation such as stretched curd cheese and yogurt appeared to be more stable against contamination during processing. In this study, for coliforms at 45 °C, only one cheese sample and 12% of total yogurt samples exceeded the Brazilian legislation limit. None of sausage samples presented any contamination. On the other hand, values found in both processing water and dairy products indicated failures in application and monitoring of good manufactured practices.

https://doi.org/10.1590/1678-4324-2020190759 761 downloads

13.

Risk factors associated with mortality among patients who had candidemia in a university hospital
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Alves, Priscila Guerino Vilela

; Melo, Sávia Gonçalves Oliveira

; Bessa, Meliza Arantes de Souza

; Brito, Murilo de Oliveira

; Menezes, Ralciane de Paula

; Araújo, Lúcio Borges de

; Penatti, Mário Paulo Amante

; Pedroso, Reginaldo dos Santos

; Röder, Denise Von Dolinger de Brito

Revista da Sociedade Brasileira de Medicina Tropical

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2020, Volume 53 elocation e20190206

Abstract: En | Text: En | PDF: En

Abstract INTRODUCTION: Bloodstream infection due to Candida spp. is a primary cause of morbidity and mortality in tertiary hospitals. METHODS: In this retrospective study, we included patients with a positive blood culture for Candida spp. after 48 h of hospitalization. RESULTS A total of 335 patients who had candidemia were included in this study. Risk factors associated with mortality were hospitalization in internal medicine units and surgical clinics, age >60 years, mechanical ventilation, orotracheal intubation, hemodialysis, corticosteroids use, and C. parapsilosis infection. CONCLUSIONS: This study highlights the importance of health care related to invasive procedures and actions to improve patient immunity.

https://doi.org/10.1590/0037-8682-0206-2019 352 downloads

14.

Hypermethylation status of DAPK, MGMT and RUNX3 in HPV negative oral and oropharyngeal squamous cell carcinoma
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Reis, Raquel Silva dos

; Santos, Jéssica Aflávio dos

; Abreu, Priscila Marinho de

; Dettogni, Raquel Spinassé

; Santos, Eldamária de Vargas Wolfgramm dos

; Stur, Elaine

; Agostini, Lidiane Pignaton

; Anders, Quézia Silva

; Alves, Lyvia Neves Rebello

; Valle, Isabella Bittencourt do

; Lima, Marília Arantes

; Souza, Evandro Duccini

; Podestá, José Roberto Vasconcelos de

; Zeidler, Sandra Ventorin von

; Cordeiro-Silva, Melissa de Freitas

; Louro, Iúri Drumond

Genetics and Molecular Biology

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2020, Volume 43 N. 3 elocation e20190334

Abstract: En | Text: En | PDF: En

Abstract Squamous cell carcinoma of the oral cavity and oropharynx is the sixth most common type of cancer in the world. During tumorigenesis, gene promoter hypermethylation is considered an important mechanism of transcription silencing of tumor suppressor genes, such as DAPK, MGMT and RUNX3. These genes participate in signaling pathways related to apoptosis, DNA repair and proliferation whose loss of expression is possibly associated with cancer development and progression. In order to investigate associations between hypermethylation and clinicopathological and prognostic parameters, promoter methylation was evaluated in 72 HPV negative oral and oropharyngeal tumors using methylation-specific PCR. Hypermethylation frequencies found for DAPK, MGMT and RUNX3 were 38.88%, 19.44% and 1.38% respectively. Patients with MGMT hypermethylation had a better 2-year overall survival compared to patients without methylation. Being MGMT a repair gene for alkylating agents, it could be a biomarker of treatment response for patients who are candidates for cisplatin chemotherapy, predicting drug resistance. In view of the considerable levels of hypermethylation in cancer cells and, for MGMT, its prognostic relevance, DAPK and MGMT show potential as epigenetic markers, in a way that additional studies may test its viability and efficacy in clinical management.

https://doi.org/10.1590/1678-4685-gmb-2019-0334 879 downloads

15.

Aortic valve endocarditis due to Bartonella clarridgeiae in a dog in Brazil
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André, Marcos Rogério

; Canola, Raphaela Arantes Marques

; Braz, Jaislane Bastos

; Perossi, Isabella Fernanda Spinelli

; Calchi, Ana Claudia

; Ikeda, Priscila

; Machado, Rosangela Zacarias

; Vasconcelos, Rosemeri de Oliveira

; Camacho, Aparecido Antonio

Revista Brasileira de Parasitologia Veterinária

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dec 2019, Volume 28 N. 4 Pages 661 - 670

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Relatamos o primeiro caso documentado de endocardite associada à Bartonella clarridgeiae em um cão na América Latina. Endocardite aórtica valvar vegetativa infecciosa foi diagnosticada em um cão sem raça definida de 10 anos de idade. O cão apresentou sopro sistólico e diastólico de grau V / VI, hipertermia e perda progressiva de peso. Cardiomegalia e presença de padrão alveolar difuso nos campos pulmonares foram observados na avaliação radiográfica do tórax. Estruturas irregulares e hiperecogênicas aderidas aos folhetos aórticos, causando obstrução da via de saída do ventrículo esquerdo e insuficiência aórtica grave, foram observadas na avaliação ecocardiográfica. À necropsia, foi observada uma estrutura vegetativa, esbranquiçada e endurecida medindo 1,0 cm de diâmetro na válvula semilunar aórtica. Por meio de uma combinação de cultura líquida baseada em meio de pré-enriquecimento de inseto, ensaios de PCR quantitativa em tempo real e convencional baseados nos genes nuoG e gltA, respectivamente, seguidos de sequenciamento e inferências filogenéticas, DNA de B. clarridgeiae foi detectado no tecido valvular lesionado do paciente. O diagnóstico de endocardite vegetativa aórtica grave, possivelmente causado por B. clarridgeiae em um cão no Brasil, foi apoiado por características clínicas, ecocardiográficas, anatomopatológicas e moleculares.

Abstract We report the first documented case of endocarditis associated with Bartonella clarridgeiae in a dog in Latin America. Infective vegetative valvular aortic endocarditis was diagnosed in a 10-year-old male mixed breed dog. The dog presented grade V/VI systolic and diastolic murmur, hyperthermia, and progressive weight loss. Cardiomegaly and presence of diffuse alveolar pattern in the lung fields were observed in the thorax radiography evaluation. Irregular and hyperechogenic structures adhered to the aortic leaflets, causing obstruction of the left ventricular outflow tract and severe aortic insufficiency, were observed in the echocardiography evaluation. A vegetative, whitish, hardened structure measuring 1.0 cm in diameter was observed in aortic semilunar valve at necropsy. Based on a combination of pre-enrichment insect-based medium liquid culture, quantitative real-time and conventional PCR assays based on nuoG and gltA genes, respectively, followed by sequencing and phylogenetic inferences, B. clarridgeiae DNA was detected in the patient’s aortic valve lesions. Clinical, echocardiographic, anatomopathologic and molecular features supported the diagnosis of severe aortic vegetative endocarditis possibly caused by B. clarridgeiae in a dog in Brazil.

https://doi.org/10.1590/s1984-29612019078 950 downloads

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