Abstract The aim of this study was to compare potential aspects of periapical lesion formation in hypertensive and normotensive conditions using hypertensive (BPH/2J) and wild-type control (BPN/3J) mice. The mandibular first molars of both strains had their dental pulp exposed. At day 21 the mice were euthanized and right mandibular molars were used to evaluate the size and phenotype of apical periodontitis by microCT. Proteins were extracted from periapical lesion on the left side and the expressions of IL1α, IL1β and TNFα were analyzed by ELISA. Bone marrow stem cells were isolated from adult mice femurs from 2 strains and osteoclast differentiation was evaluated by tartrate-resistant acid phosphatase (TRAP) in vitro. The amount of differentiated osteoclastic cells was nearly double in hypertensive mice when compared to the normotensive strain (p < 0.03). Periapical lesion size did not differ between hypertensive and normotensive strains (p > 0.7). IL1α, IL1β and TNFα cytokines expressions were similar for both systemic conditions (p > 0.05). Despite the fact that no differences could be observed in periapical lesion size and cytokines expressions on the systemic conditions tested, hypertension showed an elevated number of osteoclast differentiation.
Subject and invention: the Borromean topology in the clinical approach to psychosis. Based on J. Lacan's theoretical approach to Borromean topology in the seventies decade we emphasize some aspects of the case of James Joyce as an introduction to discuss a clinical case of psychosis known as "Profeta Gentileza". We propose to demonstrate his stabilization strategies which concern his preaching as a 'mission' received through an 'astral sign'. This analysis includes his work upon the signifier, with the creation of a neological writing, his naming as a prophet and its effects on the subject's jouissance. We also engage in a topological discussion about the case demonstrating how Borromean topology can be functional to psychoanalytical practice with psychosis.
A partir dos aportes teóricos de J. Lacan acerca da topologia borromeana na década de 1970, ressaltaremos alguns aspectos do caso do escritor James Joyce como introdução à discussão de um caso clínico de psicose. Trata-se do Profeta Gentileza. Tentaremos demonstrar as estratégias de estabilização adotadas por ele, a partir da 'missão' de pregação recebida como 'aviso astral'. Nessa análise, incluímos o trabalho sobre o significante, a invenção de sua escrita com grafia neológica, a nominação e seus efeitos sobre o gozo. Ensaiaremos uma discussão topológica do caso, demonstrando como a topologia borromeana pode contribuir para a abordagem psicanalítica da psicose.