Abstract This study analyzed the prevalence of complete neonatal screening (CNS) of children aged under 2 years in Brazil and associated factors using data from the 2013 (n=4,442) and 2019 (n=5,643) national health surveys. We conducted a cross-sectional study to compare prevalence of CNS (eye, ear and heel prick tests) adopting 95% confidence intervals (95%CI) and a 5% significance level. Crude and adjusted Poisson regression was performed to estimate prevalence ratios (PR) and 95%CI to assess the association between socioeconomic, demographic and health variables and CNS. There was a statistically significant increase in CNS prevalence, from 49.2% (95%CI: 47.1-51.3) in 2013 to 67.4% (95%CI: 65.5-69.3) in 2019. However, large disparities persist across states and between sociodemographic groups. In both years, CNS prevalence was lowest among brown and black children, those from families in the three lowest income quintiles, children without health insurance, those from families registered in the Family Health Strategy and children living in the North, cities outside the state capital/metropolitan regions and rural areas. Despite the increase in prevalence of CNS, deep individual and contextual inequalities persist, posing challenges for health policies. (CNS 201 n=4,442 n4442 n 4 442 (n=4,442 n=5,643 n5643 5 643 (n=5,643 surveys crosssectional cross sectional eye, eye (eye tests 95 95CI CI (95%CI level PR (PR socioeconomic 492 49 49.2 47.151.3 471513 47.1 51.3 47 1 51 3 47.1-51.3 674 67 67.4 65.569.3 655693 65.5 69.3 65 69 65.5-69.3 However groups quintiles insurance North capitalmetropolitan capital metropolitan areas policies 20 n=4,44 n444 44 (n=4,44 n=5,64 n564 64 (n=5,64 9 49. 151 47.151. 47151 471 47. 513 51. 47.1-51. 6 67. 569 65.569. 65569 655 65. 693 69. 65.5-69. n=4,4 n44 (n=4,4 n=5,6 n56 (n=5,6 15 47.151 4715 47.1-51 56 65.569 6556 65.5-69 n=4, n4 (n=4, n=5, n5 (n=5, 47.15 47.1-5 65.56 65.5-6 n=4 (n=4 n=5 (n=5 47.1- 65.5- n= (n= (n

Resumo Analisou-se a prevalência e fatores associados à realização da Triagem Neonatal Completa (TNC) entre crianças (<2 anos de idade) no Brasil incluídas na Pesquisa Nacional Saúde 2013 (n=4.442) e 2019 (n=5.643). Estudo transversal comparou as estimativas de prevalência e intervalos de confiança de 95% (IC95%) da TNC (testes do olhinho, orelhinha e pezinho). Diferenças foram consideradas estatisticamente significante ao nível de 5%. Regressões de Poisson bruta e ajustada foram realizadas para estimar Razões de Prevalência (RP) e IC95% para a associação das variáveis socioeconômicas, demográficas e de saúde com a TNC. Verificou-se aumento estatisticamente significante da TNC: 67,4% (IC95%: 65,5-69,3) em 2019, ante 49,2% (IC95%: 47,1-51,3) em 2013. Porém, ainda existem desigualdades e defasagens entre os estados da federação e variáveis sociodemográficas. Entre os anos, a TNC foi menor nas crianças de cor/raça parda e preta, dos três piores quintis de renda, sem plano de saúde, cadastradas na Estratégia de Saúde da Família, da região norte, de cidades do interior e da zona rural do Brasil. Apesar de o aumento da prevalência de TNC, desigualdades e defasagens individuais e contextuais permaneceram, indicando os desafios das políticas de saúde. Analisouse Analisou se (TNC <2 2 (< idade 201 n=4.442 n4442 n 4 442 (n=4.442 n=5.643. n5643 n=5.643 . 5 643 (n=5.643) 95 IC95 IC (IC95% testes olhinho pezinho. pezinho pezinho) 5% RP (RP socioeconômicas Verificouse Verificou 674 67 67,4 65,569,3 655693 65,5 69,3 65 69 3 65,5-69,3 492 49 49,2 47,151,3 471513 47,1 51,3 47 1 51 47,1-51,3 Porém sociodemográficas corraça cor raça preta renda Família norte permaneceram < ( 20 n=4.44 n444 44 (n=4.44 n564 n=5.64 64 (n=5.643 9 IC9 (IC95 6 67, 569 65,569, 65569 655 65, 693 69, 65,5-69, 49, 151 47,151, 47151 471 47, 513 51, 47,1-51, n=4.4 n44 (n=4.4 n56 n=5.6 (n=5.64 (IC9 56 65,569 6556 65,5-69 15 47,151 4715 47,1-51 n=4. n4 (n=4. n5 n=5. (n=5.6 (IC 65,56 65,5-6 47,15 47,1-5 n=4 (n=4 n=5 (n=5. 65,5- 47,1- n= (n= (n=5 (n

Resumo Analisou-se a prevalência e fatores associados à realização da Triagem Neonatal Completa (TNC) entre crianças (<2 anos de idade) no Brasil incluídas na Pesquisa Nacional Saúde 2013 (n=4.442) e 2019 (n=5.643). Estudo transversal comparou as estimativas de prevalência e intervalos de confiança de 95% (IC95%) da TNC (testes do olhinho, orelhinha e pezinho). Diferenças foram consideradas estatisticamente significante ao nível de 5%. Regressões de Poisson bruta e ajustada foram realizadas para estimar Razões de Prevalência (RP) e IC95% para a associação das variáveis socioeconômicas, demográficas e de saúde com a TNC. Verificou-se aumento estatisticamente significante da TNC: 67,4% (IC95%: 65,5-69,3) em 2019, ante 49,2% (IC95%: 47,1-51,3) em 2013. Porém, ainda existem desigualdades e defasagens entre os estados da federação e variáveis sociodemográficas. Entre os anos, a TNC foi menor nas crianças de cor/raça parda e preta, dos três piores quintis de renda, sem plano de saúde, cadastradas na Estratégia de Saúde da Família, da região norte, de cidades do interior e da zona rural do Brasil. Apesar de o aumento da prevalência de TNC, desigualdades e defasagens individuais e contextuais permaneceram, indicando os desafios das políticas de saúde.

Abstract This study analyzed the prevalence of complete neonatal screening (CNS) of children aged under 2 years in Brazil and associated factors using data from the 2013 (n=4,442) and 2019 (n=5,643) national health surveys. We conducted a cross-sectional study to compare prevalence of CNS (eye, ear and heel prick tests) adopting 95% confidence intervals (95%CI) and a 5% significance level. Crude and adjusted Poisson regression was performed to estimate prevalence ratios (PR) and 95%CI to assess the association between socioeconomic, demographic and health variables and CNS. There was a statistically significant increase in CNS prevalence, from 49.2% (95%CI: 47.1-51.3) in 2013 to 67.4% (95%CI: 65.5-69.3) in 2019. However, large disparities persist across states and between sociodemographic groups. In both years, CNS prevalence was lowest among brown and black children, those from families in the three lowest income quintiles, children without health insurance, those from families registered in the Family Health Strategy and children living in the North, cities outside the state capital/metropolitan regions and rural areas. Despite the increase in prevalence of CNS, deep individual and contextual inequalities persist, posing challenges for health policies.

ABSTRACT Objective: To analyze the compliance with the commercialization of children's products included in the Brazilian Code of Marketing of Infant and Toddlers Food and Childcare-Related Products (NBCAL) in drugstores in Uberlândia/MG. Methods: A cross-sectional study was carried out in 143 drugstores that sold infant products: infant formula (IF), follow-up IF, nipples, teats, pacifiers and nipple shields; FI for young children, transition foods and cereal-based foods, fluid or powdered milk, modified/similar milks of plant origin and dairy compounds. The location of drugstores in the five geographic sectors was performed by geoprocessing. The data collected were: types of promotion and types of drugstore administration (drugstore chains/drugstores with independent administration). Irregular commercial promotion was expressed as absolute and relative frequencies. Results: Irregular commercial promotion was found in 11.7% of nipples, pacifiers and bottles, in 10.0% of IF and follow-up formula, in 9.5% of IF for young children, in 11.1% fluid or powdered milk, in 25.0% of transition foods and cereal-based foods and in 59.1% of dairy compounds. In commercial drugstore chains, the presence of promotion for dairy (81.8 vs. 28.6%, respectively) was higher than in drugstores with independent administration. The opposite ocurred for fluid or powdered milk, modified and similar milks of plant origin. The downtown and eastern sectors had the highest percentages of promotions (26%). Conclusions: NBCAL violations still occur in drugstores, mainly in the sale of young children's foods and in the commercial network drugstores. Objective childrens children s ChildcareRelated Childcare Related (NBCAL UberlândiaMG Uberlândia MG Uberlândia/MG Methods crosssectional cross sectional 14 , (IF) followup follow up nipples teats shields cerealbased cereal based milk modifiedsimilar compounds geoprocessing were chainsdrugstores chains . administration) frequencies Results 117 11 7 11.7 bottles 100 10 0 10.0 95 9 5 9.5 111 1 11.1 250 25 25.0 591 59 59.1 81.8 818 81 8 (81. vs 286 28 6 28.6% respectively 26%. 26 26% (26%) Conclusions (IF 11. 10. 9. 2 25. 59. 81. (81 28.6 (26% (8 28. (26 ( (2

RESUMO Objetivo: Analisar a conformidade da comercialização dos produtos infantis incluídos na Norma Brasileira de Comercialização de Alimentos para Lactentes e Crianças de Primeira Infância, Bicos, Chupetas e Mamadeira (NBCAL) e de compostos lácteos em drogarias de Uberlândia/MG. Métodos: Estudo transversal realizado em 143 drogarias que vendiam produtos infantis: fórmulas infantis (FI) para lactentes, FI de seguimento para lactentes, mamadeiras, bicos, chupetas e protetores de mamilo; FI para crianças de primeira infância, alimentos de transição e alimentos à base de cereais, leites fluidos/em pó, leites modificados/similares de origem vegetal e composto lácteo. A localização das drogarias nos cinco setores geográficos foi realizada por geoprocessamento. Os dados coletados foram: tipos de promoção comercial irregular e tipo de administração da drogaria (rede/independente). As promoções comerciais irregulares foram expressas em frequências absoluta e relativa. Resultados: Verificamos a presença de promoção comercial irregular em 11,7% dos bicos, chupetas e mamadeiras, em 10,0% das FI lactentes/seguimento de lactentes, em 9,5% das FI para crianças de primeira infância, em 11,1% dos leites, em 25,0% de alimentos de transição e em 59,1% dos compostos lácteos. Nas drogarias de rede, a presença de promoção comercial irregular foi maior para compostos lácteos (81,8 vs. 28,6%, respectivamente) e, para leites, foi maior nas drogarias independentes (30,8 vs. 6,0%). Os setores central e leste apresentaram os maiores percentuais de promoção comercial irregular (26%). Conclusões: As violações à NBCAL ainda ocorrem nas drogarias, principalmente para os produtos destinados às crianças de primeira infância, e nas drogarias de rede. Objetivo Infância Bicos (NBCAL UberlândiaMG Uberlândia MG Uberlândia/MG Métodos 14 (FI lactentes mamadeiras bicos mamilo infância cereais fluidosem fluidos pó modificadossimilares modificados similares lácteo geoprocessamento rede/independente. redeindependente rede/independente . rede independente (rede/independente) relativa Resultados 117 11 7 11,7 100 10 0 10,0 lactentesseguimento 95 9 5 9,5 111 1 11,1 250 25 25,0 591 59 59,1 81,8 818 81 8 (81, vs 286 28 6 28,6% respectivamente 30,8 308 30 (30, 6,0%. 60 6,0% 6,0%) 26%. 26 26% (26%) Conclusões (rede/independente 11, 10, 9, 2 25, 59, 81, (81 28,6 30, 3 (30 6,0 (26% (8 28, (3 6, (26 ( (2

Resumen Objetivo Evaluar la presencia de isquemia en la parte distal de las manos de los miembros superiores con fístula arteriovenosa (FAV) de pacientes en terapia de reemplazo renal (TRR) a través de la termografía infrarroja. Métodos Muestra compuesta por 15 pacientes en TRR por hemodiálisis mediante FAV que respondieron un cuestionario elaborado por los propios autores con las siguientes variables: datos sociodemográficos, diagnóstico, signos vitales y datos sobre la FAV. Para obtener los termogramas de las manos con y sin FAV, se utilizó una cámara termográfica infrarroja C5, FLIR Systems, ubicada a 50 cm de las manos de los participantes, favoreciendo el encuadramiento bilateral y encuadrando ambas manos. Los datos obtenidos se organizaron en una planilla de Excel 2011® y se compararon estadísticamente con el programa Microcal Origin 6.0, para evaluar si había diferencia entre los promedios de temperatura. Resultados Con relación a las variables sociodemográficas, el género masculino fue predominante, grupo de edad promedio de 45 años, educación primaria (incompleta/completa), casados y provenientes de otros municipios. La termografía demostró que hay diferencia de temperatura entre las manos con FAV y sin FAV, con una variación de temperatura de 1,78°C (± DP 1,99°C), menor en las manos con FAV. Conclusión El análisis de la distribución de la sangre de las manos por medio de termografía puede ofrecer evidencias sobre la microcirculación periférica y guiar el diagnóstico temprano y el tratamiento de la isquemia inducida por FAV en individuos en TRR, como una herramienta innovadora de diagnóstico auxiliar de las complicaciones de los accesos vasculares de pacientes en hemodiálisis. (FAV (TRR 1 sociodemográficos C5 C Systems 5 participantes 2011 60 6 0 6.0 sociodemográficas predominante 4 años incompleta/completa, incompletacompleta incompleta/completa , incompleta completa (incompleta/completa) municipios 178C 78 ± ( 1,99°C, 199C 1,99°C 99 1,99°C) 201 6. (incompleta/completa 7 9 20 2

Abstract Objective To assess the presence of ischemia in the distal portion of the hands of the upper limbs with arteriovenous fistula (AVF) in patients undergoing renal replacement therapy (RRT) using infrared thermography. Method The sample consisted of 15 patients on RRT via hemodialysis using an AVF who answered a questionnaire prepared by the authors themselves with sociodemographic data, diagnosis, vital signs and data on AVF. To obtain thermograms of hands with and without AVF, a C5 infrared thermographic camera, FLIR Systems, was used, fixed 50 cm from participants’ hands, favoring bilateral framing of both hands. The data obtained were organized in an Excel 2011® spreadsheet and statistically compared using the Microcal Origin 6.0 program to assess whether there was a difference between temperature averages. Results Regarding sociodemographic variables, males were predominant, with a mean age of 45 years, (incomplete/complete) elementary school, married and from other municipalities. Thermography demonstrated that there is a difference in temperature between hands with AVF and without AVF, with a temperature variation of 1.78°C (± SD 1.99°C), lower for hands with AVF. Conclusion The analysis of hand blood distribution using thermography can provide evidence on peripheral microcirculation and guide the early diagnosis and treatment of AVF-induced ischemia in individuals undergoing RRT as an innovative auxiliary diagnostic tool for complications of venous access in hemodialysis patients. (AVF (RRT 1 C camera Systems used 5 participants 2011 60 6 0 6. averages variables predominant 4 years incomplete/complete incompletecomplete incomplete complete (incomplete/complete school municipalities 178C 78 ± ( 1.99°C, 199C 1.99°C , 99 1.99°C) AVFinduced induced 201 7 9 20 2

Resumo Objetivo Avaliar a presença de isquemia na porção distal das mãos dos membros superiores com Fistula Arteriovenosa (FAV) de pacientes em Terapia Renal Substitutiva (TRS) através da termografia por infravermelho. Método Amostra composta por 15 pacientes em TRS por hemodiálise por meio de FAV que responderam um questionário elaborado pelos próprios autores com as seguintes variáveis: dados sociodemográficos, diagnóstico, sinais vitais e dados sobre a FAV. Para obtenção dos termogramas das mãos com e sem FAV foi utilizado uma câmera termográfica por infravermelho C5, FLIR Systems, fixada a 50 cm das mãos dos participantes, privilegiando o enquadramento bilateral enquadrando ambas as mãos. Os dados obtidos foram organizados em planilha de Excel 2011® e comparados estatisticamente utilizando o programa Microcal Origin 6.0, para avaliar se existia diferença entre as médias de temperatura. Resultados Com relação as variáveis sociodemográficas, o gênero masculino foi o predominante, faixa etária com média de 45 anos, ensino fundamental (incompleto/completo), casados e provenientes de outros municípios. A termografia demonstrou que há diferença de temperatura entre as mãos com FAV e sem FAV, com variação na temperatura de 1,78°C (± DP 1,99°C), menor para as mãos com FAV. Conclusão A análise da distribuição do sangue das mãos por meio da termografia pode fornecer evidências sobre a microcirculação periférica e orientar o diagnóstico precoce e o tratamento da isquemia induzida por FAV em indivíduos em TRS, como ferramenta inovadora de diagnóstico auxiliar das complicações dos acessos venosos de pacientes em hemodiálise. (FAV (TRS 1 sociodemográficos C5 C Systems 5 participantes 2011 60 6 0 6.0 sociodemográficas predominante 4 anos incompleto/completo, incompletocompleto incompleto/completo , incompleto completo (incompleto/completo) municípios 178C 78 ± ( 1,99°C, 199C 1,99°C 99 1,99°C) 201 6. (incompleto/completo 7 9 20 2

The aim of the present study was to evaluate the effect of roasting and cocoa mass content on the composition of chocolates. Chocolate formulations were developed (40, 50, 60 and 70% cocoa solids) using unroasted and roasted cocoa beans, and analyses were performed: physicochemical, chemical composition, antioxidant capacity, procyanidin content, total phenolic compounds, quantification of theobromine, caffeine, catechin and epicatechin by high performance liquid chromatography (HPLC) and spectroscopic profile by mid-infrared spectroscopy (MIR). The results revealed that higher values of total phenolics, epicatechin and procyanidins, were obtained in chocolates produced with unroasted cocoa beans, with a significant difference in relation to those with roasted cocoa beans. It was observed that increasing the percentage of cocoa in the formulations caused an increase in the content of bioactive compounds. The use of MIR in the differentiation of chocolate samples produced with roasted and unroasted cocoa beans obtained a positive result. This technique associated with principal component analysis (PCA) enabled the separation of chocolates according to the type of cocoa bean (roasted and unroasted) used in production, confirming its importance for a quick evaluation of the parameters. 40, 40 (40 50 6 70 solids performed physicochemical capacity compounds theobromine caffeine HPLC (HPLC midinfrared mid infrared MIR. . (MIR) phenolics procyanidins result PCA (PCA production parameters 4 (4 5 7 (MIR (

Abstract The aquatic insects of the genus Phylloicus play a crucial role in aquatic ecosystems, shredding leaves and contributing to nutrient cycling in streams. Therefore, this genus is often used in laboratory experiments. However, in Cerrado regions such as Araguaia, these studies are impractical due to a lack of knowledge about basic aspects, such as their feeding preferences for local plants. Hence, our objective is to determine the native plant species in the Araguaia region preferred as food by Phylloicus. We conducted an experimental study comparing the consumption of three native Cerrado plant species: Casearia sylvestris, Astronium fraxinifolium, and Ficus guaranítica by Phylloicus. To assess differences in consumption, we performed an Analysis of Variance. The results revealed that Phylloicus larvae exhibited a feeding preference for Casearia sylvestris (F = 9.71; p = 0.004). This finding will contribute to the development of future experimental studies using Phylloicus in the Araguaia region, as understanding the feeding preferences of animals used in experiments is essential for their maintenance in the laboratory. ecosystems streams Therefore However aspects plants Hence fraxinifolium Variance F 9.71 971 9 71 0.004. 0004 0.004 . 0 004 0.004) 9.7 97 7 000 0.00 00 9. 0.0 0.

Resumo Os insetos aquáticos do gênero Phylloicus desempenham um papel essencial nos ecossistemas aquáticos, fragmentando folhas e contribuindo para a ciclagem de nutrientes nos riachos. Por isso, esse gênero é frequentemente utilizado em experimentos de laboratório. No entanto, em regiões de Cerrado como o Araguaia, esses trabalhos são inviáveis por não se conhecer aspectos básicos como a sua preferência alimentar por plantas locais. Por isso, nosso objetivo é responder quais são as espécies vegetais nativas da região do Araguaia preferidas para a alimentação de Phylloicus. Fizemos um trabalho experimental comparando o consumo de três espécies vegetais nativas do Cerrado: Casearia sylvestris, Astronium fraxinifolium e Ficus guaranítica pelos Phylloicus. Para avaliar as diferenças no consumo, realizamos uma Análise de Variância. Os resultados obtidos revelaram que as larvas de Phylloicus demonstraram preferência alimentar por Casearia sylvestris (F = 9.71; p = 0.004). Esse achado ajudará no desenvolvimento de futuros trabalhos experimentais utilizando Phylloicus na região do Araguaia, uma vez que é essencial o conhecimento da preferência alimentar dos animais utilizados nos experimentos para sua manutenção em laboratório. riachos isso laboratório entanto locais Variância F 9.71 971 9 71 0.004. 0004 0.004 . 0 004 0.004) 9.7 97 7 000 0.00 00 9. 0.0 0.

Abstract Reinforced concrete structures must be designed in a manner that assures an acceptable level of safety and performance. However, accidents still occur nowadays causing interdiction, financial losses, or even human casualties. Therefore, succinct studies are required to give answers to such an undesirable situation, helping to prevent repetition and enlightening new design and construction methods. This paper analyzes the failure mechanism in a large reinforced concrete panel composed of one L-shaped cantilevered wall and structural walls in Campinas. The investigation was carried out using in-situ destructive and non-destructive tests and also through numerical simulation. In-situ tests revealed that the region where the fracture happened had no sufficient resisting steel area. The fracture line developed through the end of the wall’s horizontal rebars anchored within the column. It was concluded that the reinforced concrete panel failure happened due to structure misconception and incorrect design, once columns stirrups were responsible for the equilibrium of the cantilevered part of the building, as demonstrated by the nonlinear finite element study and in-situ investigations. performance However interdiction losses casualties Therefore situation methods Lshaped L shaped Campinas insitu situ nondestructive non simulation Insitu In area s column building investigations

Resumo Estruturas de concreto armado devem ser projetadas de maneira a garantir um nível aceitável de segurança e desempenho. Porém, acidentes ainda são observados atualmente causando interdições, perdas financeiras, e até mesmo humanas. Portanto, estudos aprofundados são necessários para responder a essas situações indesejáveis, prevenindo sua repetição e desenvolvendo novas formas de dimensionamento e construção. O presente trabalho analisa o mecanismo de falha observado em um extenso painel de concreto armado composto por uma parede em balanço apoiada em um pilar parede, localizados na cidade de Campinas. As investigações foram realizadas in loco utilizando testes destrutíveis e não destrutíveis e também via simulações numéricas. Os testes in loco revelaram que a região onde ocorreu a ruptura localizada não possuía quantidade suficiente de armadura metálica. A linha de fratura se desenvolveu no término das armaduras horizontais da parede. Concluiu-se que a falha do painel ocorreu devido a erros de concepção e dimensionamento, dado que os estribos do pilar-parede foram responsáveis pelo equilíbrio da parte em balanço da edificação, como ficou demonstrado pelo estudo utilizando análise não linear via Elementos Finitos e pelas investigações in-loco. desempenho Porém interdições financeiras humanas Portanto indesejáveis construção Campinas numéricas metálica Concluiuse Concluiu pilarparede edificação inloco. inloco loco. in-loco

Abstract In low and middle-income countries such as Brazil, most maternal deaths are related to hypertensive complications. Preeclampsia is the leading cause of maternal mortality and morbidity. Significant proportion is associated with the following factors: lack of identification of high-risk women, lack of adequate prevention, difficulty in maintaining a high-risk prenatal follow-up, delayed diagnosis, insecurity and low use of magnesium sulphate, delayed pregnancy interruption and lack of postpartum follow-up of these high-risk cases. Four major actions are proposed to minimize this alarming clinical picture and reduce the mortality rates due to preeclampsia, called the "4 P Rule" (Adequate Prevention – Vigilant Prenatal Care – Timely Delivery (Parturition) – Safe Postpartum). From this simple "rule" we can open a range of important processes and reminders that may help in the guidance of preeclampsia management. middleincome middle income Brazil complications morbidity factors highrisk high risk women prevention followup, followup follow up, up diagnosis sulphate cases 4 " Rule Adequate Parturition (Parturition Postpartum. Postpartum . Postpartum) rule "rule management

ABSTRACT Du e to the concern with the contamination of food by pesticides, especially coffee, the aim of this study was to analyze the chemical composition and glyphosate residue in Conilon coffee beans with and without defects and harvested at different times after applying the herbicide. The experiment was in a split-plot design, with the presence or absence of defects in the beans comprising the subplots, and the periods of 15, 30, 45 and 60 days after applying the herbicide corresponding to the split plots. We analyzed the volatile compounds, bioactive compounds, and glyphosate residue in the beans. Regardless of the presence or absence of defects, there was an increase in the concentrations of bioactive compounds in the raw Conilon coffee beans as the interval between applying the herbicide and harvesting the beans was increased. The most abundant volatile compounds per percentage area belonged to the pyrazines, furans and phenols. The amount of glyphosate residue found in the beans exceeded the maximum detectable limit by the ELISA method regardless of the time between application and harvest, corresponding to values that are unacceptable to several purchasing countries, and making the samples unsuitable for export and a risk to food safety. pesticides splitplot plot design subplots 15 30 4 6 plots increased pyrazines phenols harvest countries safety 1 3

Abstract Background Robust data on the learning curve (LC) of transcatheter aortic valve replacement (TAVR) are lacking in developing countries. Objective To assess TAVR’s LC in Brazil over time. Methods We analyzed data from the Brazilian TAVR registry from 2008 to 2023. Patients from each center were numbered chronologically in case sequence numbers (CSNs). LC was performed using restricted cubic splines adjusted for EuroSCORE-II and the use of new-generation prostheses. Also, in-hospital outcomes were compared between groups defined according to the level of experience based on the CSN: 1st to 40th (initial-experience), 41st to 80th (early-experience), 81st to 120th (intermediate-experience), and over 121st (high-experience). Additional analysis was performed grouping hospitals according to the number of cases treated before 2014 (>40 and ≤40 procedures). The level of significance adopted was <0.05. Results A total of 3,194 patients from 25 centers were included. Mean age and EuroSCORE II were 80.7±8.1 years and 7±7.1, respectively. LC analysis demonstrated a drop in adjusted in-hospital mortality after treating 40 patients. A leveling off of the curve was observed after case #118. In-hospital mortality across the groups was 8.6%, 7.7%, 5.9%, and 3.7% for initial-, early-, intermediate-, and high-experience, respectively (p<0.001). High experience independently predicted lower mortality (OR 0.57, p=0.013 vs. initial experience). Low-volume centers before 2014 showed no significant decrease in the likelihood of death with gained experience, whereas high-volume centers had a continuous improvement after case #10. Conclusion A TAVR LC phenomenon was observed for in-hospital mortality in Brazil. This effect was more pronounced in centers that treated their first 40 cases before 2014 than those that reached this milestone after 2014. (LC (TAVR countries TAVRs s time 200 2023 CSNs. CSNs . (CSNs) EuroSCOREII newgeneration new generation prostheses Also inhospital hospital CSN st th initialexperience, initialexperience , (initial-experience) earlyexperience, earlyexperience early (early-experience) intermediateexperience, intermediateexperience intermediate (intermediate-experience) highexperience. highexperience high (high-experience) 201 >40 (>4 ≤4 procedures. procedures procedures) 005 0 05 <0.05 3194 3 194 3,19 2 included 80781 80 7 8 1 80.7±8. 771 7±7.1 4 118 #118 Inhospital In 86 6 8.6% 77 7.7% 59 5 9 5.9% 37 3.7 initial, initial- early, early- intermediate, intermediate- highexperience, high-experience p<0.001. p0001 p p<0.001 001 (p<0.001) OR 057 57 0.57 p0013 013 p=0.01 vs experience. experience) Lowvolume Low volume highvolume 10 #10 20 202 (CSNs (initial-experience (early-experience (intermediate-experience (high-experience >4 (> ≤ 00 <0.0 319 19 3,1 8078 80.7±8 7±7. 11 #11 8.6 7.7 5.9 3. p000 p<0.00 (p<0.001 0.5 p001 01 p=0.0 #1 > ( <0. 31 3, 807 80.7± 7±7 8. 7. 5. p00 p<0.0 (p<0.00 0. p=0. # <0 80.7 7± p0 p<0. (p<0.0 p=0 < 80. p<0 (p<0. p= p< (p<0 (p< (p

Resumo Fundamento Dados robustos sobre a curva de aprendizagem (LC) da substituição da válvula aórtica transcateter (TAVR) são escassos nos países em desenvolvimento. Objetivo Avaliar a LC da TAVR no Brasil ao longo do tempo. Métodos Analisamos dados do registro brasileiro de TAVR de 2008 a 2023. Pacientes de cada centro foram numerados cronologicamente em número sequencial de caso (NSC). A LC foi realizada usando um spline cúbico restrito ajustado para o EuroSCORE-II e o uso de próteses de nova geração. Ainda, os desfechos hospitalares foram comparados entre grupos definidos de acordo com o nível de experiência, com base no NSC: 1º ao 40º caso (experiência inicial), 41º ao 80º caso (experiência básica), 81º ao 120º caso (experiência intermediária) e 121º caso em diante (experiência alta). Análises adicionais foram conduzidas de acordo com o número de casos tratados antes de 2014 (>40 e ≤40 procedimentos). O nível de significância adotado foi p <0,05. Resultados Foram incluídos 3194 pacientes de 25 centros. A idade média foi 80,7±8,1 anos e o EuroSCORE II médio foi 7±7,1. A análise da LC demonstrou uma queda na mortalidade hospitalar ajustada após o tratamento de 40 pacientes. Um patamar de nivelamento na curva foi observado após o caso 118. A mortalidade hospitalar entre os grupos foi 8,6%, 7,7%, 5,9%, e 3,7% para experiência inicial, básica, intermediária e alta, respectivamente (p<0,001). A experiência alta foi preditora independente de mortalidade mais baixa (OR 0,57, p=0,013 vs. experiência inicial). Centros com baixo volume de casos antes de 2014 não mostraram uma redução significativa na probabilidade de morte com o ganho de experiência, enquanto centros com alto volume de casos antes de 2014 apresentaram uma melhora contínua após o caso de número 10. Conclusão Observou-se um fenômeno de LC para a mortalidade hospitalar do TAVR no Brasil. Esse efeito foi mais pronunciado em centros que trataram seus 40 primeiros casos antes de 2014 que naqueles que o fizeram após 2014. (LC (TAVR desenvolvimento tempo 200 2023 NSC. NSC . (NSC) EuroSCOREII geração Ainda º inicial , inicial) básica básica) alta. alta) 201 >40 (>4 ≤4 procedimentos. procedimentos procedimentos) 005 0 05 <0,05 319 2 80781 80 7 8 1 80,7±8, 771 7±7,1 4 118 86 6 8,6% 77 7,7% 59 5 9 5,9% 37 3 3,7 p<0,001. p0001 p<0,001 001 (p<0,001) OR 057 57 0,57 p0013 013 p=0,01 vs inicial. 10 Observouse Observou se 20 202 (NSC >4 (> ≤ 00 <0,0 31 8078 80,7±8 7±7, 11 8,6 7,7 5,9 3, p000 p<0,00 (p<0,001 0,5 p001 01 p=0,0 > ( <0, 807 80,7± 7±7 8, 7, 5, p00 p<0,0 (p<0,00 0, p=0, <0 80,7 7± p0 p<0, (p<0,0 p=0 < 80, p<0 (p<0, p= p< (p<0 (p< (p

Abstract Treatment of oral vascular anomalies (OVA) has focused on minimally invasive techniques rather than radical surgery. We investigated the efficacy and safety of diode laser using the photocoagulation technique in the management of OVA. Forty-seven subjects with OVA were treated with forced dehydration with induced photocoagulation (FDIP) using diode laser (808 nm/4.5 W). This series consisted mostly of male (63.8%) and non-white (63.8%) patients with a mean age of 57.4 years. Varices (91.5%), venous malformations (6.4%), and hemangiomas (2.1%) with a mean size of 7.1 (±4.9) mm were the conditions treated. OVA presented as a nodular lesion (63.8%) involving mainly the lower lip (46.8%). Pulsed laser mode was used as standard and the number of applications varied from one to four sessions, with the majority requiring only one (83%) FDIP session. Kaplan-Meier analysis revealed that complete clinical healing can occur on the 15th day (n=9/29.5%), followed by the 20th (n=6/45.5%), and 30th (n=7/70.5%) days. Postoperative edema was observed in 31 (66%) patients, and recurrence of the lesion occurred in two (4.2%). Based on the data on complete clinical healing, minimal patient discomfort, and satisfactory esthetic results, we can confirm that FDIP by diode laser is a promising candidate for the safe and efficacious treatment of OVA. (OVA surgery Fortyseven Forty seven (FDIP 808 (80 nm45 nm 4 5 nm/4. W. W . W) 63.8% 638 63 8 (63.8% nonwhite non white 574 57 57. years 91.5%, 915 91.5% , 91 (91.5%) 6.4%, 64 6.4% 6 (6.4%) 2.1% 21 2 1 (2.1% 71 7 7. ±4.9 49 9 (±4.9 46.8%. 468 46.8% 46 (46.8%) sessions 83% 83 (83% session KaplanMeier Kaplan Meier th n=9/29.5%, n9295 n n=9/29.5% 29 (n=9/29.5%) n=6/45.5%, n6455 n=6/45.5% 45 (n=6/45.5%) n=7/70.5% n7705 70 (n=7/70.5% days 3 66% 66 (66% 4.2%. 42 4.2% (4.2%) discomfort results 80 (8 nm4 nm/4 63.8 (63.8 91.5 (91.5% 6.4 (6.4% 2.1 (2.1 ±4. (±4. 46.8 (46.8% (83 n929 n=9/29.5 (n=9/29.5% n645 n=6/45.5 (n=6/45.5% n=7/70.5 n770 (n=7/70.5 (66 4.2 (4.2% ( nm/ 63. (63. 91. (91.5 6. (6.4 2. (2. ±4 (±4 46. (46.8 n92 n=9/29. (n=9/29.5 n64 n=6/45. (n=6/45.5 n=7/70. n77 (n=7/70. (6 4. (4.2 (63 (91. (6. (2 ± (± (46. n9 n=9/29 (n=9/29. n6 n=6/45 (n=6/45. n=7/70 n7 (n=7/70 (4. (91 (46 n=9/2 (n=9/29 n=6/4 (n=6/45 n=7/7 (n=7/7 (4 (9 n=9/ (n=9/2 n=6/ (n=6/4 n=7/ (n=7/ n=9 (n=9/ n=6 (n=6/ n=7 (n=7 n= (n=9 (n=6 (n= (n

RESUMEN Objetivo: evaluar la calidad de vida laboral de los profesionales sanitarios que prestan atención directa e indirecta a los casos de COVID-19. Métodos: se trata de un estudio transversal llevado a cabo con 156 profesionales sanitarios de un hospital de referencia. Se investigó la relación entre las variables sociodemográficas, laborales y el estrés percibido y los dominios de la Escala de Evaluación de la Calidad de Vida Laboral mediante estadística inferencial y de regresión. Resultados: la satisfacción por Compasión fue moderada (media: 38,2), con nivel de estrés percibido, Burnout y Estrés Traumático Secundario bajos (medias: 18,8, 21,6 y 19,1). Hubo asociaciones entre: escolaridad, sueldo, pluriempleo y atención directa con la Satisfacción por Compasión; bajos ingresos, ser enfermero y hacer horas extras con el Burnout; y trabajar más de 12 horas, enfermedad subyacente y hospitalización por COVID-19 con Estrés Traumático Secundario. Conclusión: la calidad de vida en el trabajo fue satisfactoria, a pesar de la presencia de Burnout y Estrés Traumático Secundario. Objetivo COVID19. COVID19 COVID 19. 19 Métodos 15 referencia sociodemográficas regresión Resultados media (media 38,2, 382 38,2 , 38 2 38,2) medias (medias 188 18 8 18,8 216 21 6 21, 19,1. 191 19,1 . 1 19,1) escolaridad sueldo ingresos COVID-1 Conclusión satisfactoria COVID1 38, 3 18, 19, COVID-

RESUMO Objetivo: avaliar a qualidade de vida no trabalho dos profissionais da saúde em atendimento direto e indireto de casos de covid-19. Métodos: estudo transversal com 156 profissionais da saúde de um hospital de referência. Investigou-se a relação entre variáveis sociodemográficas, laborais e percepção de estresse e domínios da Escala de Avaliação da Qualidade de Vida no Trabalho, por meio de estatística inferencial e de regressão. Resultados: a Satisfação por Compaixão foi moderada (média: 38,2), com percepção de estresse, Burnout e Estresse Traumático Secundário baixos (médias: 18,8, 21,6 e 19,1). Houve associações entre: escolaridade, salário, múltiplos empregos e atendimento direto com o aspecto Satisfação por Compaixão; baixa renda, ser enfermeiro e trabalhar horas extras com Burnout; e trabalhar mais de 12 horas, doença de base e internação por covid-19 com Estresse Traumático Secundário. Conclusão: a qualidade de vida no trabalho foi satisfatória, apesar da presença de Burnout e Estresse Traumático Secundário. Objetivo covid19. covid19 covid 19. 19 Métodos 15 referência Investigouse Investigou se sociodemográficas Trabalho regressão Resultados média (média 38,2, 382 38,2 , 38 2 38,2) médias (médias 188 18 8 18,8 216 21 6 21, 19,1. 191 19,1 . 1 19,1) escolaridade salário renda covid-1 Conclusão satisfatória covid1 38, 3 18, 19, covid-

ABSTRACT Objective: to evaluate the quality of life at work of health professionals in direct and indirect care of COVID-19 cases. Methods: this was a cross-sectional study with 156 health professionals from a referral hospital. The relationship between sociodemographic and work-related variables and perceived stress and domains of the Quality of Life at Work Scale was investigated using inferential statistics and regression. Results: Satisfaction with Compassion was moderate (mean: 38.2), with low perception of stress, Burnout and Secondary Traumatic Stress (means: 18.8, 21.6 and 19.1). There were associations between: education, salary, multiple jobs and direct care with Compassion Satisfaction; low income, being a nurse and working overtime with Burnout; and working more than 12 hours, underlying disease and hospitalization for COVID-19 with Secondary Traumatic Stress. Conclusion: quality of life at work was satisfactory, despite the presence of Burnout and Secondary Traumatic Stress. Objective COVID19 COVID 19 COVID-1 cases Methods crosssectional cross sectional 15 hospital workrelated related regression Results mean (mean 38.2, 382 38.2 , 38 2 38.2) means (means 188 18 8 18.8 216 21 6 21. 19.1. 191 19.1 . 1 19.1) education salary income hours Conclusion satisfactory COVID1 COVID- 38. 3 18. 19.

Abstract The objective of this work was to produce dark chocolates with the addition of coffee husk flour (CHF) and to evaluate the generated effects on their physical, physicochemical, microbiological, textural, and rheological characteristics. Husks of the Pacamara coffee (Coffea arabica) variety, produced under organic management, were used. The samples were previously dried, ground, and sieved at 0.250 mm. Five chocolate formulations were previously standardized at 55% content of cocoa solids (mass and cocoa butter) and at 0.4% soy lecithin. The addition of CHF was tested at the concentrations of 0, 2.5, 5.0, 7.5, and 10%, using a completely randomized design and three replicates. The addition of CHF up to 10% alters the physicochemical, textural, and rheological properties of the chocolate formulations, but without compromising their composition and quality. The tested formulations only differed regarding hardness and cohesiveness, evaluated in the texture profile. The hardness of the chocolate formulations increases as CHF is added. (CHF physical physicochemical microbiological textural characteristics Coffea arabica variety management used dried ground 0250 0 250 0.25 mm 55 mass butter 04 4 0.4 lecithin 25 2 5 2.5 50 5.0 75 7 7.5 10 replicates quality cohesiveness profile added 025 0.2 0. 2. 5. 7. 1 02

Resumo O objetivo deste trabalho foi produzir chocolates amargos com adição de farinha de casca de café (CHF) e avaliar os efeitos gerados nas suas características físicas, físico-químicas, microbiológicas, de textura e reológicas. Foram utilizadas cascas da variedade de café (Coffea arabica) Pacamara, produzida com manejo orgânico. As amostras foram previamente secas, moídas e peneiradas a 0,250 mm. Cinco formulações de chocolates foram previamente padronizadas em 55% de teor de sólidos de cacau (massa e manteiga de cacau) e em 0,4% de lecitina de soja. A adição de CHF foi testada nas concentrações de 0, 2,5, 5,0, 7,5 e 10%, tendo-se utilizado delineamento inteiramente casualizado e três repetições. A adição de CHF até 10% altera as propriedades físico-químicas, de textura e reológicas das formulações de chocolate, mas sem comprometer sua composição e sua qualidade. As formulações testadas diferiram apenas quanto à dureza e à coesividade, avaliadas no perfil de textura. A dureza das formulações de chocolate aumenta à medida que a CHF é adicionada. (CHF físicas físicoquímicas, físicoquímicas físico químicas, químicas físico-químicas microbiológicas Coffea arabica Pacamara orgânico secas 0250 0 250 0,25 mm 55 massa 04 4 0,4 soja 25 2 5 2,5 50 5,0 75 7 7, 10 tendose tendo se repetições qualidade coesividade adicionada 025 0,2 2, 5, 1 02

Abstract Objectives: Identifying voice handicap and voice-related quality of life in patients presenting pulmonary impairment associated with COVID-19 infection, comparing pulmonary parameters between these patients and individuals in the control group, as well as correlating pulmonary parameters to self-assessment questionnaires (IDV-10 and QVV). Methods: Thirty-five (35) patients presenting pulmonary impairment with COVID-19 infection were herein selected and compared to 35 individuals who were not affected by COVID-19 infection. Two self-assessment questionnaires were applied (vocal handicap index and voice quality of life protocol). Maximum phonation time Forced Expiratory Pressure (PEF) and Forced Inspiratory Pressure (PIF) were measured and videolaryngoscopy was performed. Results: There was statistically significant difference in scores recorded in voice self-assessment questionnaires (IDV-10 and QVV), Expiratory Pressure (PEF) and Forced Inspiratory Pressure (PIF) between patients with pulmonary impairment associated with COVID-19 infection and those in the control group. Correlation between PEF/PIF and scores recorded in voice self-assessment questionnaires was also observed. Conclusion: Pulmonary impairment associated with COVID-19 infection has worsened voice handicap and voice-related quality of life in the assessed patients, as well as reduced their forced expiratory and inspiratory pressure in comparison to the control group. Level of evidence: 4. Objectives voicerelated related COVID19 COVID 19 COVID-1 group selfassessment self assessment IDV10 IDV 10 (IDV-1 QVV. QVV . QVV) Methods Thirtyfive Thirty five (35 3 vocal protocol. protocol protocol) PEF (PEF PIF (PIF performed Results QVV, , PEFPIF observed Conclusion evidence 4 COVID1 1 COVID- IDV1 (IDV- (3 (IDV (