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ABSTRACT Objective Peak oxygen consumption (VO2peak), anaerobic threshold, walking economy, and cardiovascular responses during walking are used to guide and monitor walking training in patients with peripheral artery disease and intermittent claudication. Women with peripheral artery disease and intermittent claudication present greater impairments than men, and evaluating training markers according to sex for decisions regarding walking prescription in this population is important. This study aimed to compare VO2peak, walking economy, anaerobic threshold, and cardiovascular responses during walking in men and women with peripheral artery disease and intermittent claudication. Methods Forty patients (20 men and 20 women with similar baseline characteristics) underwent a cardiopulmonary treadmill test (3.2km/h and 2% increase in slope every 2 minutes until maximal leg pain). The VO2 and rate-pressure product were assessed. Data from men and women were compared using t-tests. Results There were no significant differences between men and women (VO2peak: 15.0±4.8 versus 13.9±2.9mL∙kg-1∙min-1, p=0.38; walking economy: 9.6±2.7 versus 8.4±1.6mL∙kg-1∙min-1, p=0.09; anaerobic threshold: 10.5±3.2 versus 10.5±2.2mL∙kg-1∙min-1, p=0.98; rate pressure product at 1st stage: 13,465± 2,910 versus 14,445±4,379bpm∙mmHg, p=0.41; and rate pressure product at anaerobic threshold:13,673±3,100 versus 16,390±5,870bpm∙mmHg, p=0.08 and rate pressure product at peak exercise: 21,253±6,141 versus 21,923±7,414bpm∙mmHg, p=0.76, respectively). Conclusion Men and women with peripheral artery disease and similar baseline characteristics presented similar responses to walking, suggesting that decisions regarding walking prescription and monitoring can be made regardless of sex in this specific population. VO2peak VOpeak , VO (VO2peak) threshold economy important (2 3.2km/h 32kmh kmh 3 2km h km pain. pain . pain) ratepressure assessed ttests. ttests t tests. tests t-tests (VO2peak 15048 15 0 4 8 15.0±4. 13.9±2.9mL∙kg1∙min1, 13929mLkg1min1 mLkgmin 13.9±2.9mL∙kg 1∙min 1, 13 9 9mL kg 1 min mL 13.9±2.9mL∙kg-1∙min-1 p=0.38 p038 p 38 9627 6 7 9.6±2. 8.4±1.6mL∙kg1∙min1, 8416mLkg1min1 8.4±1.6mL∙kg 6mL 8.4±1.6mL∙kg-1∙min-1 p=0.09 p009 09 10532 10 5 10.5±3. 10.5±2.2mL∙kg1∙min1, 10522mLkg1min1 10.5±2.2mL∙kg 2mL 10.5±2.2mL∙kg-1∙min-1 p=0.98 p098 98 st stage 13465 465 13,465 2910 910 2,91 144454379bpmmmHg bpmmmHg 14 445 379bpm mmHg bpm 14,445±4,379bpm∙mmHg p=0.41 p041 41 threshold13,673±3,100 threshold136733100 13,673±3,100 673 100 threshold:13,673±3,10 163905870bpmmmHg 16 390 870bpm 16,390±5,870bpm∙mmHg p008 08 p=0.0 exercise 212536141 21 253 141 21,253±6,14 219237414bpmmmHg 923 414bpm 21,923±7,414bpm∙mmHg p076 76 p=0.76 respectively. respectively respectively) ( 1504 15.0±4 kg1 min1 13.9±2.9mL∙kg1∙min1 mLkg 13929mLkg1min 13929mLkg 1min 13.9±2.9mL∙kg-1∙min- p=0.3 p03 962 9.6±2 8.4±1.6mL∙kg1∙min1 8416mLkg1min 8416mLkg 8.4±1.6mL∙kg-1∙min- p00 1053 10.5±3 10.5±2.2mL∙kg1∙min1 10522mLkg1min 10522mLkg 10.5±2.2mL∙kg-1∙min- p=0.9 p09 1346 46 13,46 291 91 2,9 44 p=0.4 p04 threshold13 threshold13,673±3,10 threshold13673310 136733100 13,673±3,10 67 threshold:13,673±3,1 39 p=0. 21253614 25 21,253±6,1 92 p07 p=0.7 150 15.0± 13.9±2.9mL∙kg1∙min 13.9±2.9mL∙kg-1∙min p0 96 9.6± 8.4±1.6mL∙kg1∙min 8.4±1.6mL∙kg-1∙min 105 10.5± 10.5±2.2mL∙kg1∙min 10.5±2.2mL∙kg-1∙min 134 13,4 29 2, threshold1 threshold13,673±3,1 threshold1367331 13673310 13,673±3,1 threshold:13,673±3, p=0 2125361 21,253±6, 15.0 9.6 10.5 13, threshold13,673±3, threshold136733 1367331 13,673±3, threshold:13,673±3 p= 212536 21,253±6 15. 9. 10. threshold13,673±3 threshold13673 136733 13,673±3 threshold:13,673± 21253 21,253± threshold13,673± threshold1367 13673 13,673± threshold:13,673 2125 21,253 threshold13,673 threshold136 1367 13,673 threshold:13,67 212 21,25 threshold13,67 136 13,67 threshold:13,6 21,2 threshold13,6 13,6 threshold:13, 21, threshold13, threshold:13 threshold:1