Objectives: To compare the concordance of prostate cancer (PCa) laterality between the extended transperineal (TP) or transrectal (TR) prostate biopsy (BP) and radical prostatectomy (RP) specimens. To identify predictors of laterality agreement between BP and RP. Materials and Methods: Data from 533 consecutive patients with PCa (278 TP and 255 TR-diagnosed) treated with RP were analyzed. A 12-core technique was used for both TP and TR biopsies. Additional cores were obtained when necessary. Results: Overall, the percentage of agreement of PCa laterality between BP and RP was 60% (K = 0.27, p < 0.001). However, the RP confirmation of unilaterality at BP was obtained in just 33% of the cases. Considering the concordance on bilaterality as the “target” of our analysis, the sensitivity and specificity were 54.3% and 98.2%, respectively, with TP and 47.5% and 92.5%, respectively with TR. Focusing on patients with unilaterality at biopsy, none of the evaluated preoperative variables (biopsy technique, age, total positive biopsy cores, PSA, prostate volume, Gleason score on biopsy) were able to predict RP bilaterality in the multivariate analyses. Conclusions: Most of the patients with unilateral involvement at BP harbored bilateral PCa after RP. TR and TP biopsy showed no difference in their capacity to predict the concordance of tumor laterality at RP. None of the preoperative evaluated variables can predict the tumor laterality at RP. Using BP unilaterality to include patients in focal therapy (FT) protocols may hinder the oncologic efficacy of FT.

Liver samples of Oreochromis niloticus cultivated in floating net cages were fixed for histological and ultrastructural studies with the objective of describing the hepatic parenchymal structure and the intrahepatic exocrine pancreatic tissue. Anatomically, the liver showed only two hepatic lobes. Histological analysis demonstrated that the hepatocytes were spread out as anastomotic cords, arranged in two cellular layers and surrounded by sinusoids. The intrahepatic exocrine pancreatic tissue exhibited an acinar arrangement and was diffused in the hepatic parenchyma. Structural analysis showed that the hepatocytes had a rounded nucleus and a rough endoplasmic reticulum with a parallel disposition to the nuclear membrane. The exocrine pancreatic cells showed secretion granules at the apical portion and the rough endoplasmic reticulum was concentrically distributed

Con el objetivo de describir la estructura del parénquima hepático y del páncreas exocrino intrahepático del Oreochromis niloticus, fueron fijados para estudios histológicos y ultraestructurales fragmentos de hígado de peces cultivados en jaulas flotantes. Se evidenciaron sólo 2 lóbubos hepáticos. El análisis histológico demostró que los hepatocitos se encontraban organizados en forma de cordones anastomosados, dispuestos en dos capas celulares y cercados por sinusoides. El tejido pancreático exocrino intrahepático se encontró difuso en el parénquima hepático y se destacó por su organización acinar. El análisis ultraestructural demostró que los hepatocitos presentaban núcleos redondos y el retículo endoplasmático rugoso estaba dispuesto paralelamente a la membrana nuclear. Las células pancreáticas exocrinas presentaban gránulos de secreción localizados en la porción apical y el retículo endoplasmático rugoso estaba organizado de manera concéntrica

The boundary tissue of the dog epididymal duct showed concentric lamellae of mioconnective tissue in which were observed elongated contractile cells, collagen, fibroblasts, fibrocytes, mast cells and amyelinic nerve fibers. This boundary tissue forms the periductal stroma and duct interstitium of the epididymis. The structure is described and compared with that of other mammals.

El estroma e intersticio del epidídimo del perro se presentaron como un tejido conjuntivo, en el cual se presenta fibras musculares lisas, fibras colágenas, células conjuntivas, predominando fibroblastos, fibrocitos, mastocitos y fibras nerviosas amielínicas. La organización del tejido conjuntivo del conducto epididimario fue comparada con la de otros mamíferos.

This paper deals some characteristics of mucosubstances reactivities in the epididymis of the dog. The PAS reactivity of the epithelium lining was moderate in all the segments of the duct, although strongly PAS positive granules were observed in the cytoplasm of the principal cells. These granules are probably formed by glycoproteins. Comparisons were made with data in the previous observations

Para la determinación de glucosaminoglicanos en el epidídimo del perro fueron usadas reacciones histoquímicas. En los tres segmentos del epitelio ductal la determinación de mucosustancias neutras reveló reacciones medias. No obstante, la presencia de gránulos PAS positivos en el epitelio, indicarían una probable secreción glucoproteica de las células principales. Las determinaciones histoquímicas confirman las interpretaciones previas

The epididymal region of the pigeon consists of a mass of tubules attached to the dorsomedial surface of the testis, and comprising proximal and distal efferent ductules and a short epididymal duct. The efferent ductules are lined by a stereociliated pseudostratified epithelium and the epididymal duct by a nonciliated pseudostratified low colummnar epithelium. The morphometric evaluation showed that the proximal efferent ductules have the greatest calibre (X = 283,64 µm) in epididymal region, with possible physiological envolvement in seminal fluid resorption

La vía espermática extratesticular de la paloma está formada por los conductos eferentes proximales y distales, y por el conducto epididimario. Los conductos eferentes están revestidos por epitelio pseudo-estratificado, estereociliado y el conducto epididimario por epitelio columnar bajo, pseudo-estratificado. El análisis morfométrico demostró que los conductos eferentes proximales poseen mayor diámetro medio entre los túbulos de la región epididimaria (X: 283,64 µm); teniendo este hecho una probable implicancia fisiológica en el proceso de reabsorción del fluido seminífero

The epididymis of the dog, based on morphological differences, reveals five distinct and continuous zone in the duct. It is observed zone I and zone II, both of them localized into the head. The third zone, or zone III, comprises the distal head and all the body. The fourth and fifth zones (zones IV and V), are restricted to the tail, localized into the proximal and distal Cauda epididymidis, respectively. Each zone can be readly distinguished on the basis of its own duct morphological characteristics. This distinction concerns mainly to the overall duct histology, and also to cytological appearence and epithelial lining constitution.

La histología regional del conducto del epidídimo en el perro comprende cinco regiones histológicamente distintas y continuas. Dos de las zonas se localizan dentro de la cabeza (zona I o segmento inicial y zona II), una en la cabeza distal y en el cuerpo (zona III) y dos en la cola del epidídimo (zonas IV y zona V), situadas en la Cauda epididymidis, respectivamente. Cada zona puede distinguirse fácilmente sobre la base de variaciones de las características morfológicas del conducto. Esta distinción tiene relación con la histología del conducto en conjunto y también con el aspecto citológico y constitución del epitelio de revestimiento