The prevalence of metabolic disorders varies among ethnic populations and these disorders represent a critical health care issue for elderly women. This study investigated the correlation between genetic ancestry and body composition, metabolic traits and clinical status in a sample of elderly women. Clinical, nutritional and anthropometric data were collected from 176 volunteers. Genetic ancestry was estimated using 23 ancestry-informative markers. Pearsons correlation test was used to examine the relationship between continuous variables and an independent samples t-test was used to compare the means of continuous traits within categorical variables. Overall ancestry was a combination of European (57.49%), Native American (25.78%) and African (16.73%). Significant correlations were found for European ancestry with body mass index (r = 0.165; p = 0.037) and obesity (mean difference (MD) = 5.3%; p = 0.042). African ancestry showed a significant correlation with LDL (r = 0.159, p = 0.035), VLDL (r = -0.185; p = 0.014), hypertriglyceridemia (MD = 6.4%; p = 0.003) and hyperlipidemia (MD = 4.8%; p = 0.026). Amerindian ancestry showed a significant correlation with triglyceride levels (r = 0.150; p = 0.047) and hypertriglyceridemia (MD = 4.5%; p = 0.039). These findings suggest that genetic admixture may influence the etiology of lipid metabolism-related diseases and obesity in elderly women.

Foi feito estudo comparativo entre quatro testes imunológicos - imunoenzimático IgG (ELISA-G) e Ig M (ELISA-M), imunofluorescência indireta (RIFI) e fixação do complemento (RFC) - utilizados na detecção de anticorpos anti-Cysticercus, em soro e líquido ce-falomaquidiano (LCR) de pacientes com suspeita clínica de cisticercose e seus familiares. Foram examinados 539 pacientes que apresentavam sintomas e/ou sinais sugestivos de cisticercose, 450 familiares destes doentes e 133 pessoas que constituíram o grupo controle. Foram colhidas 1122 amostras de soro e 120 de LCR que foram analisadas por ELISA-G e RIFI; em 83 soros e 60 LCR também foi processada a RFC e em 28 LCR também a ELISA-M. A ELISA-G e a RIFI mostraram-se reagentes em 5,2% dos soros, havendo discordância entre seus resultados em 3,5%. Em todos os soros do grupo controle ambos os testes foram não-reagentes. Estas mesmas reações, no LCR, foram reagentes em 16,7% e mostraram resultados discordantes em 7,5%. Houve concordância dos resultados da ELISA-G e aa RIFI, efetuadas concomitantemente no soro e no LCR, em 89,6% dos doentes, senão 17,7% reagentes. Nos soros em que foram executadas ELISA-G, RIFI e RFC, 54,2% mostraram concordância de resultados nos três testes, sendo reagentes em 16,9%. Estas mesmas reações no LCR tiveram resultados concordantes em 81,7%, sendo 11,7% reagentes. Nas amostras que apresentaram ELISA-G e RIFI nao-reagentes, a RFC foi reagente no soro e LCR, respectivamente, em 41,0% e 11,7%. Nos LCR em que se realizaram ELISA-G e ELISA-M, houve concordancia de resultados em 78,6%; nas amostras com resultados discordantes, 10,7% tiveram ELISA-G reagente e ELISA-M não-reagente, ocorrendo o inverso nas outras 10,7%. É dada ênfase à necessidade da realização concomitantemente de vários testes imunológicos para detecção de anticorpos anti-Cysticercus, no soro e no LCR, garantindo maior segurança no diagnóstico e acompanhamento evolutivo da doença.

A comparative study of four immunological tests used for anti-Cysticercus antibodies detection - Enzyme-Linked immunoSorbent Assay IgG (ELISA-G) and IgMi (ELISA-M), indirect immunofluorescence (RIFI) and complement fixation (RFC) - was made in serum and cerebrospinal fluid (CSF). 539 patients with symptoms suggesting cysticercosis, 450 relatives of these patients and 133 normal people (control group) were examined. 1122 serum samples and 120 CSF samples were analysed by ELISA-G and RIFI, 83 sera and 60 CSF also by RFC, and 28 CSF by ELISA-M. 5.2% serum samples were reagent in ELISA-G and RIFI, and 3.5% of them had discordant results. All control group sera were negative. The same tests in CSF were positive in 16.7% and had discordant results in 7.5%. ELISA-G and RIFI in serum and CSF had concordant results in 89.6% (17.7% were positive). ELISA-G, RIFI and RFC had concordant results in 54.2% sera (16.9% positives) and in 81.7% CSF (11.7% positives). When ELISA-G and RIFI were negative, RFC was positive in 41.0% sera and 11.7% CSF. ELISA-G and ELISA-M had concordant results in 78.6% CSF. When these results were discordant ELISA - G was positive in 10.7% and ELISA -M in another 10.7%. I t is necessary tc use concomitantly several immunological tests for &nti-€ysticercus antibodies detection in serum and in CSF, in attempting to reach correct diagnosis.

Efusões pleurais surgem raramente em associação com a histoplasmose capsu-lata, ocorrendo em geral nas formas agudas da doença. Relatamos e discutimos um caso clínico em que um histoplasmoma subpleural acompanhou-se de dor pleurítica, hidrotórax e pleurite fibrosante.