Plants of the genus Crotalaria are known for their antagonistic effect against nematodes. It has been found that pyrrolizidine alkaloids are the main metabolites involved in such antagonistic activity. Aiming at obtaining extracts with higher alkaloid content and enhanced potential for use as bionematicides, we investigated the chemical composition and nematicidal activity of extracts obtained from Crotalaria juncea and Crotalaria ochroleuca cultivated in vitro through micropropagation. Remarkably, extracts from the callus of C. ochroleuca (lethal concentration of 95% (LC95) = 157.7 μg mL-1) and C. juncea (LC95 = 189.9 μg mL-1) exhibited high toxicity against Meloidogyne javanica. The ultra performance liquid chromatography coupled to quadrupole time-of-flight with high mass spectrometry (UPLC-QTOF-MSE) analysis revealed the presence of pyrrolizidine alkaloids, flavones, flavone glycosides, and isoflavones. These findings highlight the potential of tissue culture to obtain extracts from Crotalaria species compared to conventionally cultivated plants and provide a higher concentration of metabolites with nematicidal effects, paving the way for sustainable agriculture.

ABSTRACT Soil erosion in tropical environments causes environmental, social and economic damage. Canephora coffee crops are impacted by soil erosion and testing alternatives to mitigate this damage is a current need. This study aimed to evaluate the losses of sediment, organic carbon, nutrients and surface runoff caused by water erosion in between-rows spacing of Coffea canephora Pierre ex A. Froehner plants in management with and without cover crops, and the effect of the intensity of rains on sediment loss and the surface runoff. The management practices tested in between-rows spacing of coffee plants were: ES - exposed soil after manual weeding with a hoe; CC1- soil covered by palisadegrass [Urochloa brizantha (Hochst. ex A.Rich.) R.D.Webster] and nutsedge grass (Cyperus rotundus L.); and CC2- soil covered with purslane plant (Portulaca oleracea L.). Nine experimental plots were installed to measure losses of sediment, organic carbon, nutrients and surface runoff in the periods from September/2021 to March/2022 and from September to December/2022. The CC1 and CC2 reduced losses of sediment, organic carbon, nutrients and the volume of surface runoff from 37 to 86 % compared to ES. The increase in volume and rainfall intensities increased sediment loss and the surface runoff linearly, being more intense in ES management. The maintenance of the cover crops in between-rows spacing of coffee plants proved to be advantageous for mitigating losses of sediment, organic carbon, nutrients and surface runoff caused by water erosion, contributing to soil conservation and the sustainability of canephora coffee production.

Resumo Dada a crescente importância da inclusão financeira no desenvolvimento socioeconômico, este estudo busca propor um Índice de Inclusão Financeira em nível municipal para o território brasileiro, abrangendo os anos de 2016 a 2022. A análise dos dados revela que, embora tenha havido pouca mudança de 2016 a 2019, no período de 2019 a 2022 houve deterioração significativa nos níveis gerais de inclusão financeira, especialmente nas regiões Norte e Nordeste. Em 2022, a inclusão financeira mostrou-se ainda mais reduzida em todas as regiões do país. Os resultados destacam a necessidade de políticas públicas focadas na melhoria da inclusão financeira, considerando as disparidades regionais identificadas. O estudo contribui para a literatura ao oferecer uma ferramenta de medição multidimensional da inclusão financeira, considerando métricas de acesso, uso e potencial digital, em nível municipal, promovendo a compreensão das dinâmicas regionais e a formulação de políticas mais eficazes.

Abstract Given the growing importance of financial inclusion in socioeconomic development, this study aims to propose a financial inclusion index at the municipal level for the Brazilian territory, covering the years 2016 to 2022. The analysis reveals that, although there was little change from 2016 to 2019, in the period from 2019 to 2022 there was a significant deterioration in the overall levels of financial inclusion, especially in the North and Northeast regions. In 2022, financial inclusion was even more reduced in all regions of the country. The results highlight the need for public policies focused on improving financial inclusion, considering the regional disparities identified. The study contributes to the literature by offering a multidimensional measurement tool for financial inclusion, considering metrics of access, use, and digital potential, at the municipal level, promoting the understanding of regional dynamics and the formulation of more effective policies.

Resumo Introdução: a mielinólise pontina central (CMP) é caracterizada pela destruição da bainha de mielina das células oligodendríticas devido a uma elevação rápida da osmolaridade plasmática, com consequente passagem de componentes pela barreira hematoencefálica (prováveis alterações osmóticas abruptas). Descrição: gestante na sexta semana de idade gestacional, com quadro convulsivo tônico-clônico generalizado prévio nunca investigado, diabetes mellitus tipo I desde a infância e uso de drogas lícitas e ilícitas, foi admitida com diagnóstico de MP após quadro de desregulações glicêmicas, a qual evoluiu com desfecho obstétrico desfavorável, porém, prognóstico neurológico em reabilitação. Discussão: dentre as várias etiologias de MP, a correção brusca da hiponatremia é considerada como principal causa. A literatura, entretanto, descreve causas como alterações glicêmicas importantes, deficiência nutricional e abuso de substâncias. Este relato vem no escopo dos diagnósticos diferenciais, em um contexto atípico - a gestação - evidenciando uma condição multicausal e corroborando com a importância do conhecimento de tal condição na terapia intensiva e obstétrica para adequado manejo clínico multiprofissional.

Abstract Introduction: central pontine myelinolysis (CPM) is characterized by the destruction of the myelin sheath from oligodendrocytes due to a rapid increase in plasma osmolarity and consequent passage of components through the blood-brain barrier. Description: a woman at six weeks of pregnancy, presenting previous uninvestigated generalized tonic-clonic seizures, type 1 diabetes mellitus since childhood, and using both licit and illicit drugs, was admitted to the hospital with CPM diagnosed after dysglycemia. She presented an unfavorable obstetric outcome with a neurological rehabilitation prognosis. Discussion: the rapid correction of hyponatremia is considered the main cause of CPM among its different etiologies described in the literature, such as relevant dysglycemia, nutritional deficiencies, and drug abuse. This study reported differential diagnoses of CPM in an atypical context (i.e., pregnancy), emphasizing the importance of knowing this multifactorial condition in intensive and obstetric care for appropriate multi-professional clinical management.

Abstract Background: Low functional health literacy in anticoagulated patients using warfarin has been widely discussed in medical literature. Objective: To identify the quality of oral anticoagulation (QOA) over time and to analyze the association between this variable and functional health literacy. Methods: Prospective cohort study conducted at an anticoagulation clinic (AC) in Minas Gerais, in a high-complexity hospital. The study included 81 patients, whose data were collected by direct consultation of medical records or by asking questions while patients were waiting for care. The QOA was assessed at 6, 9, 12, 15, and 18 months after the beginning of this study, and analyses of the association between this variable and functional health literacy were performed at the different time points. The QOA was identified by calculating the Therapeutic Time Range (TTR), with good quality being obtained with TTR values >59%. The incidence analysis of the TTR was performed for each of the five time points of the study through univariate Poisson regression. The significance level adopted in the statistical analysis was 5%. Results: Throughout the study, inadequate control of oral anticoagulation was observed, with only 20% of the patients showing persistent improvement in TTR values. No statistically significant association was identified at the different measurement times between TTR and functional health literacy. Conclusion: There was no direct association between the QOA and functional health literacy. However, the low incidence of persistent quality of anticoagulation in patients with low literacy suggests the development of specific educational actions for this subgroup of patients.

RESUMO O desenvolvimento humano é processo de alta complexidade que inicia no nascimento e envolve o desempenho de áreas motoras e cognitivas. Avaliar possíveis alterações promove um prognóstico favorável e minimiza o prejuízo de consequências às habilidades motoras. O objetivo deste estudo é verificar a associação entre desempenho motor e funções cognitivas em crianças e adolescentes de cinco a quatorze anos. A pesquisa é observacional, transversal e quantitativa. A amostra foi composta por 268 crianças e adolescentes de ambos os sexos de duas escolas municipais de Goiânia – GO. A análise estatística de dados foi realizada no programa Statistical Package for Social Sciences com os testes U de Mann- Whitney e Shapiro-Wilk. As funções cognitivas da amostra foram avaliadas com Mini Exame Mental infantil e as habilidades motoras amplas com o teste Motor Competence Assesment, para as habilidades manipulativas do teste, chute e arremesso. O estudo verificou que o desempenho motor para as habilidades de arremessar e chutar não apresentou correlação significativa entre o desempenho cognitivo em crianças e adolescentes de 5 a 14 anos. Quanto às diferenças de desempenho entre os sexos, verificamos que os meninos apresentaram maior velocidade de arremesso e chute em relação às meninas, apesar destas terem apresentado desempenho cognitivo ligeiramente superior.

ABSTRACT The human development is a highly complex process that begins at birth and involves the performance of motor areas and cognitive functions. Assessing and diagnosing possible changes promotes a favourable prognosis and minimizes the consequences for motor skills. The objective of this study is to verify the association between motor performance and cognitive functions in children and adolescents aged five to fourteen years. The research is observational, transversal and quantitative. The sample consisted of 268 children and adolescents of both sexes from two municipal schools in Goiânia – GO. Data analysis was carried out at the Statistical Package for Social Sciences program for statistical analysis with the Mann-Whitney and Shapiro-Wilk U tests. The cognitive functions of the sample were assessed with the Mini Infant Mental Examination, and the broad motor skills were assessed with the Motor Competence Assessment test for the manipulative skills of the test, such as kicking and throwing. The study found that motor performance for throwing and kicking skills did not show a significant difference between cognitive performance in children and adolescents aged 5 to 14 years. Regarding differences in performance between the sexes, we found that boys had greater performance and kick speed compared to girls despite having superior cognitive performance.

Resumen (analítico) Vinculado al proyecto de investigación «¿Qué universidad salesiana para los jóvenes de hoy?: escuchando las voces de sus estudiantes», una asociación entre instituciones salesianas de América Latina, el artículo es el resultado de un mapeo de producciones realizadas en bases de datos de Brasil, que busca la discusión, la escritura y las miradas que se han producido, en el período de 2018 a 2021, en investigaciones académicas cuyo tema está dirigido a los grupos minoritarios que estudian en instituciones de educación superior. El artículo evidencia que, al problematizar los grupos minoritarios en la educación superior, las discusiones, los debates y los enfrentamientos para la construcción de un espacio de diálogo, autonomía y respeto son factores siempre presentes, ya que son elementos de una posición política que busca la calidad del acceso y la permanencia.

Abstract (analytical) Linked to the research Project «What salesian university for today's youth?: Listening to the voices of its students», a partnership between Salesian institutions in Latin America, the article is the result of a mapping of productions carried out in databases in Brazil, which seeks the discussion, writing and views that were produced, from 2018 to 2021, in academic research whose theme is focused on minority groups studying in higher education institutions. The article shows that when problematizing minority groups in higher education, discussions, debates and confrontations for the construction of a space for dialogue, autonomy and respect are always present factors, as they are elements of a political position that seeks the quality of the access and permanence.

Resumo Vinculado ao projeto de pesquisa «Qual universidade salesiana para os jovens de hoje?: ouvindo a voz dos alunos», parceria entre instituições salesianas da América Latina, o artigo é fruto de um mapeamento de produções realizadas em bases de dados do Brasil, que busca a discussão, a escrita e os olhares que foram produzidos, no período de 2018 a 2021, em pesquisas acadêmicas cuja a temática está voltada aos grupos minoritários que estudam em instituições de ensino superior. O artigo evidencia que ao problematizar os grupos minoritários no ensino superior, as discussões, os debates e os enfrentamentos para a construção de um espaço de diálogo, autonomia e respeito são fatores sempre presentes, pois são elementos de um posicionamento político que busca a qualidade do acesso e da permanência.

Abstract Biodiesel serves as a biodegradable, non-toxic, and renewable fuel option that offers an alternative to traditional fossil fuels. This study aimed to examine the impact of elevating biodiesel content to 20% and 50% within regular diesel, with a focus on comprehending how these fuel mixtures influence variations in soot composition using Raman spectroscopy. The soot samples under analysis originated from commercial S10 diesel, as well as fuel blends containing 20% and 50% portions of sunflower and macaúba biodiesel, whereupon the use of this methodology for these fuels characterizes the novelty of this work. The outcomes derived from analyzing the soot samples revealed distinct characteristics in the G, D1, D3, and D4 bands. The ratio between the intensities of these D and G bands is closely indicative of the soot's structure. Consequently, this ratio was analyzed in this investigation to assess the effects of biodiesel concentration and engine rotation speed on soot characteristics. The conclusions found in this study indicated that there was minimal variation in the spectral characteristics of the soot samples across the different fuels and varying engine speeds. As a result, it is inferred that increasing the proportion of biodiesel in commercial diesel S10 did not have a significant impact on the structural composition of soot.

Resumo O objetivo dos autores é apresentar uma nova técnica de coxoplastia que resolva o desconforto e estigma associados a cicatrizes na virilha ou outras regiões anteriores do corpo após coxoplastias convencionais. O estudo apresenta um relato de caso de uma técnica de coxoplastia realizada em pacientes pós-bariátricas submetidas a intenso emagrecimento, por meio de ressecção de pele em S realizada na região póstero-medial da coxa, sem cicatriz na parte anterior do corpo. As pacientes não apresentaram complicações pós-operatórias e apresentaram cicatrizes discretas. Além disso, a técnica consegue uma grande redução do excesso de pele, em múltiplos vetores, melhorando o contorno corporal. A técnica envolve o posicionamento inédito da cicatriz em forma de S nos sulcos sub-glúteos e posteromediais das coxas, sem cicatriz anterior na virilha, melhorando significativamente o ocultamento da cicatriz. Permite também não ter angulações na linha de sutura, melhor distribuição das trações cutâneas, menor chance de deiscência da ferida, ao mesmo tempo em que permite a ressecção de grandes quantidades de excesso de pele nas direções longitudinal e transversal, com tração em múltiplos vetores. A técnica de coxoplastia apresentada é um procedimento inovador, inédito, que permite um melhor ocultamento da cicatriz e provável menor incidência de complicações devido à melhor distribuição da tensão cicatricial.

Abstract This article presents a new thighplasty technique to solve the discomfort and stigma associated with scars in the groin or other anterior body regions after conventional thighplasties. This study presents a case report of a thighplasty technique performed in post-bariatric patients undergoing intense slimming. This technique relies on an S-shaped skin resection in the posteromedial region of the thigh, with no scar on the anterior part of the body. The patients did not present postoperative complications, and their scars were discrete. In addition, the technique resulted in a large excessive skin reduction in multiple vectors, improving body contour. The technique involved the unprecedented positioning of the S-shaped scar in the sub-gluteal and posteromedial grooves of the thighs, with no anterior scar in the groin, significantly improving scar concealment. Since there was no suture line angulation, cutaneous tracing distribution was better, and the chance of wound dehiscence was lower. Meanwhile, it allowed the resection of large amounts of excessive skin in longitudinal and transverse directions under multi-vector traction. This thighplasty technique is an innovative, unprecedented procedure allowing better scar concealment and probably decreases the complication rate due to the better distribution of the cicatricial tension.

■ RESUMO Introdução: Os carcinomas de queratinócitos, basocelular e espinocelular, são os principais tipos de câncer de pele não melanoma (CPNM). Embora não representem um alto risco de mortalidade, essas neoplasias têm um impacto significativo na saúde pública, causando prejuízos estéticos e funcionais, principalmente em áreas constantemente expostas ao sol, como a cabeça, pescoço e face. A cirurgia é uma abordagem estabelecida no tratamento do CPNM. O presente estudo tem como objetivo traçar um perfil epidemiológico dos pacientes submetidos à cirurgia para o tratamento de CPNM pelo serviço de cirurgia plástica do Hospital das Clínicas da Universidade Federal de Minas Gerais (UFMG). Método: Realizou-se um estudo epidemiológico descritivo no Ambulatório Borges da Costa do Hospital das Clínicas da UFMG, entre março e agosto de 2023. Um formulário foi desenvolvido para a coleta de dados, abrangendo variáveis relevantes para a análise epidemiológica. Resultados: A amostra de 26 pacientes apresentou uma média de idade de 69 anos, com predominância de pacientes brancos (88,4%). As lesões foram mais frequentes no nariz (53,8%), terço médio lateral da face (20,5%), e frontal (12,8%). Quanto à margem, 55,8% vieram com margens livres, 41,1% comprometidas e 2,9% com margens exíguas. Conclusão: Os resultados destacam a necessidade de sistematização do fluxo assistencial para pacientes com CPNM, visando uma compilação e avaliação mais eficaz. Além disso, as peculiaridades epidemiológicas dos pacientes atendidos puderam ser identificadas e avaliadas através do formulário proposto, fornecendo insights para melhorias no atendimento e na gestão do câncer de pele não melanoma no hospital.

■ ABSTRACT Introduction: Keratinocyte, basal cell, and squamous cell carcinomas are the main types of non-melanoma skin cancer (NMSC). Although they do not represent a high risk of mortality, these neoplasms have a significant impact on public health, causing aesthetic and functional damage, especially in areas constantly exposed to the sun, such as the head, neck, and face. Surgery is an established approach in the treatment of NMSC. The present study aims to outline an epidemiological profile of patients undergoing surgery for the treatment of NMSC by the plastic surgery service of the Hospital das Clínicas of the Federal University of Minas Gerais (UFMG). Method: A descriptive epidemiological study was carried out at the Borges da Costa Outpatient Clinic of the Hospital das Clínicas of UFMG between March and August 2023. A form was developed for data collection, covering variables relevant to the epidemiological analysis. Results: The sample of 26 patients had a mean age of 69 years, with a predominance of white patients (88.4%). The lesions were most frequent on the nose (53.8%), lateral middle third of the face (20.5%), and forehead (12.8%). Regarding the margin, 55.8% had free margins, 41.1% had compromised margins, and 2.9% had narrow margins. Conclusion: The results highlight the need to systematize the care flow for patients with NMSC, aiming at a more effective compilation and evaluation. In addition, the epidemiological peculiarities of the patients treated could be identified and evaluated through the proposed form, providing insights for improvements in the care and management of non-melanoma skin cancer in the hospital.

Abstract Introduction Perianal fistula is a common colorectal disease which is caused mainly by cryptoglandular disease. Although most cases are treated successfully by surgery, management of complex perianal fistulas (CPAF) remains a challenge with limited results in recurrence and sometimes associated with fecal incontinence. The CPAF treatment with autologous adipose-derived mesenchymal stem cells (ASCs) had become a research hotspot. The technique started to be used in the treatment of Crohn's disease (CD) fistulas, where the studies showed safe and goods result from the procedure. Cultured ASCs have been used but this approach requires the preceding collection of adipose tissue, time for isolation of ASCs and subsequent in vitro expansion, need for laboratory facilities, and expertise in cell culturing. These factors have been getting over by using the commercially available alternative, allogenic ASCs. Treatment with allogeneic ASCs has shown good results in patients with CD fistulas, however with the disadvantage of being expensive. Objective To show that the injection with freshly collected adipose tissue is an alternative to treatment with autologous or allogenic ASCs with several advantages. Methods: In this case report, we show our first experience in the treatment of CPAF with the application of collected adipose tissue in a tertiary referral hospital from Belo Horizonte, Brazil. Results The patient had a good postoperative recuperation with a complete fistula healing after 8 months without adverse effects. Conclusion Injection with freshly collected adipose tissue is a promising and apparently safe sphincter-sparing technique in the treatment of CPAF.

ABSTRACT Background: Approximately 71 million people are chronically infected with hepatitis C virus (HCV) worldwide. A significant number of these individuals will develop liver cirrhosis and/or hepatocellular carcinoma. Beyond the liver, there is a sizeable body of scientific evidence linking cardiovascular disease and chronic hepatitis C (CHC); however, the biological mechanisms behind the concurrence of these conditions have not been completely clarified yet. Objective: To evaluate associations between hepatic histology, clinical comorbidities and lipid profile in patients with CHC. To investigate associations between liver histology and demographic, nutritional, biochemical and virological parameters. Methods: Eight-five patients with CHC prospectively underwent hepatic biopsy. Liver fragments were obtained from each patient by percutaneous route using a Menghini needle. Fibrosis was evaluated according to the METAVIR scoring system, as follows: F0, no fibrosis; F1, fibrous portal expansion; F2, fibrous portal widening with few septa; F3, bridging fibrosis with architectural distortion; and F4, liver cirrhosis. The activity was classified based on the degree of lymphocyte infiltration and hepatocyte necrosis, from A0 to A3. The diagnosis of liver disease was based on clinical, biochemical, histological, and radiological methods. The data were analyzed by logistic regression models. Results: This cross-sectional study included 85 outpatients followed at the tertiary care ambulatory centre with a mean age of 57.2±10.7 years and 45 (52.9%) were females. There were 10 patients with cirrhosis. Patients with a METAVIR F3-F4 were significantly older (P=0.02) and had higher levels of ALT (P=0.0006), AST (P<0.0001), γ-GT (P=0.03) and bilirubin (P=0.001) and higher prothrombin time than patients with F0-F2 score. Albumin levels (P=0.01) were significantly lower in METAVIR F3-F4. Age (OR=1.09; 95%CI=1.02-1.16; P=0.02), steatosis (OR=4.03; 95%CI=1.05-15.45; P=0.04) and high-density lipoprotein cholesterol (HDL-C) <60 mg/dL (OR=7.67; 95%CI=1.71-34.49; P=0.008) were independently associated with fibrosis. Hypertension (OR=6.36; 95%CI=1.31-30.85; P=0.02) and HDL-C <60 mg/dL (OR=9.85; 95%CI=2.35-41.39; P=0.002) were independently associated with necroinflammatory activity. Hypertension (OR=6.94; 95%CI=1.92-25.05; P=0.003) and HDL-C <60 mg/dL (OR=3.94; 95%CI=1.27-12.3; P=0.02) were associated with interface inflammatory activity. Triglycerides (TG ≥150 mg/dL) remained associated with lobular inflammatory activity. Conclusion: cholesterol levels <60 mg/dL were independently associated with necroinflammatory activity in chronic hepatitis C. Patients with hypertension are at an increased risk of developing necroinflammatory activity.

RESUMO Contexto: Aproximadamente 71 milhões de pessoas estão infectadas pelo vírus da hepatite C em todo o mundo. Um número significativo desses indivíduos desenvolverá cirrose hepática e/ou carcinoma hepatocelular. Além do fígado, há evidências científicas que associam doenças cardiovasculares e hepatite C crônica; no entanto, os mecanismos biológicos implicados na ocorrência dessas condições ainda não foram completamente esclarecidos. Objetivo: Avaliar a associação entre histologia hepática, comorbidades clínicas e perfil lipídico em pacientes com hepatite C crônica. Investigar associações entre histologia hepática e parâmetros demográficos, nutricionais, bioquímicos e virológicos. Métodos: Oitenta e cinco pacientes com hepatite C crônica foram prospectivamente submetidos à biópsia hepática. Biópsias hepáticas foram obtidas de cada paciente por via percutânea com agulha de Menghini. A fibrose foi avaliada de acordo com o sistema de pontuação METAVIR, como segue: F0, sem fibrose; F1, expansão portal fibrosa; F2, alargamento portal fibroso com poucos septos; F3, fibrose em ponte com distorção arquitetônica; e F4, cirrose hepática. A atividade foi classificada com base no grau de infiltração de linfócitos e necrose de hepatócitos, de A0 a A3. O diagnóstico da doença hepática foi baseado em métodos clínicos, bioquímicos, histológicos e radiológicos. Os dados foram analisados por modelos de regressão logística. Resultados: Neste estudo transversal, realizado em um ambulatório do hospital universitário, foram incluídos 85 pacientes que tinham média de idade de 57,2±10,7 anos, sendo 45 (52,9%) do sexo feminino. Havia 10 pacientes com cirrose. Os pacientes com METAVIR F3-F4 eram significativamente mais velhos (P=0,02) e tinham níveis mais elevados de ALT (P=0,0006), AST (P<0,0001), γ-GT (P=0,03) e bilirrubina (P=0,001) e, maior tempo de protrombina do que pacientes com escore F0-F2. Os níveis de albumina (P=0,01) foram significativamente mais baixos naqueles classificados como METAVIR F3-F4. Idade (OR=1,09; IC95%=1,02-1,16; P=0,02), esteatose (OR=4,03; IC95%=1,05-15,45; P=0,04) e HDL-C <60 mg/dL (OR=7,67; 95%IC=1,71-34,49; P=0,008) foram independentemente associados à fibrose. Hipertensão (OR=6,36; IC95%=1,31-30,85; P=0,02) e HDL-C <60 mg/dL (OR=9,85; IC95%=2,35-41,39; P=0,002) foram independentemente associados à atividade necroinflamatória. Hipertensão (OR=6,94; IC 95%=1,92-25,05; P=0,003) e HDL-C <60 mg/dL (OR=3,94; IC95%=1,27-12,3; P=0,02) foram associados à atividade inflamatória de interface. Os triglicerídeos (TG >150 mg/dL) permaneceram associados à atividade inflamatória lobular. Conclusão: Níveis de coleterol HDL <60 mg/dL foram independentemente associados à atividade necroinflamatória na hepatite C crônica. Pacientes com hipertensão têm risco aumentado de desenvolver atividade necroinflamatória.

RESUMEN La presente investigación cualitativa, desarrollada a partir del método de historia de vida, tuvo como objetivo investigar la aproximación entre agroecología y salud pública, con especial atención a la dimensión de las relaciones de género. Se utilizaron los siguientes instrumentos de investigación: entrevistas en profundidad, observación no sistemática y diario de campo. Todas las entrevistas fueron grabadas, transcritas y sometidas a análisis de contenido. Los informes de los participantes de la investigación fueron categorizados con base en el análisis de contenido temático-categórico: i) vivir en una región semiárida; ii) movimiento social de base y fortalecimiento de las relaciones de género; iii) agroecología, sentidos y prácticas de salud. Los resultados del estudio apuntan al enfoque sistémico de la agroecología, además de un modelo de producción agrícola, se destaca su carácter psicosocial, colectivo y político, capaz de ampliar experiencias para combatir las inequidades en salud y valorar formas de vida diversificadas.

RESUMO A presente pesquisa qualitativa, desenvolvida a partir do método de história de vida, objetivou investigar a aproximação entre agroecologia e saúde coletiva, com especial atenção para a dimensão das relações de gênero. Foram utilizados, como instrumentos da pesquisa, entrevistas em profundidade, observação assistemática e diário de campo. Todas as entrevistas realizadas foram gravadas, transcritas e submetidas à análise de conteúdo. Os relatos da única participante da pesquisa foram categorizados, através da análise de conteúdo temático-categorial: i) a roça e a convivência com o semiárido; ii) o movimento social de base e fortalecimento das relações de gênero; iii) agroecologia, sentidos e práticas de saúde. Os resultados do estudo apontam para o enfoque sistêmico da agroecologia, o qual, para além de um modelo de produção agrícola, destaca seu caráter psicossocial, coletivo e político, capaz de ampliar experiências de combate a iniquidades em saúde e valorizar modos de vida diversificados.

ABSTRACT This is a qualitative biographical research, developed from the life history method, in order to understand the connections between agroecology and public health, with special attention to the dimensions of gender relations. The following research instruments were used: in-depth interviews, unsystematic observation and a field diary. All interviews were recorded, transcribed and submitted to content analysis. The reports of the research participant were categorized based on the analysis of thematic-categorical content: i) living in a semiarid region; ii) grassroots social movement and strengthening of gender relations; iii) agroecology, health senses and practices. The results of the study point to the systemic focus of agroecology, in addition to a model of agricultural production, highlighting its psychosocial, collective and political character, capable of expanding experiences of combating inequities in health and valuing diversified ways of life.

RESUMO O café é uma das principais commodities do agronegócio mundial e de grande relevância econômica e social para o Brasil. A falta de mão de obra e seu alto custo são fatores que preocupam os cafeicultores, principalmente na colheita do café conilon, feita manualmente. O objetivo deste trabalho foi avaliar a eficiência de uma colhedora automotriz em diferentes condições de ajuste da máquina e condução da lavoura de café conilon e medir sua influência no custo de colheita comparada a colheita manual. Foram avaliados os fatores velocidade de colheita (800 a 1600 m h-1), rotação do cilindro vibrador de varetas (1,0 e 1,5 RPM), número de ramos ortotrópicos (um, dois e três) e plantas com e sem os ramos plagiotrópicos no terço inferior. O aumento da velocidade de colheita reduziu as eficiências de derriça e de colheita e a desfolha. O aumento de um para três ramos ortotrópicos por planta aumentou as eficiências de colheita e de derriça, a perda de chão e a desfolha e reduziu a carga pendente. O manejo sem os ramos plagiotrópicos apresentou maior eficiência de colheita, menor perda de chão e menor desfolha. As velocidades de colheita de 800 a 1600 m h-1 reduziram os custos totais e unitários em até 62% em relação à colheita manual. O aumento da eficiência de colheita acima de 70% reduziu os custos de colheita em até 79% em relação à colheita manual.

ABSTRACT Coffee is one of the main commodities of global agribusiness and of outstanding economic and social relevance for Brazil. The lack of labor and its high cost are factors that worry coffee producers, mainly during the conilon coffee harvesting, which is performed manually. This study aimed to evaluate the efficiency of a self-propelled harvester under different conditions of machine adjustment and conduction of the Coffea canephora crop and measure its influence on the cost of harvesting compared to manual harvesting. Harvesting speed (800 to 1600 m h-1), rotation of the vibrating rod cylinder (1.0 and 1.5 RPM), number of orthotropic branches (one, two, and three), and plants with and without plagiotropic branches in the lower third were assessed. The increase in harvesting speed reduced the efficiencies of stripping and harvesting and defoliation. Increasing from one to three orthotropic branches per plant increased harvesting and stripping efficiencies, fruit loss on the ground, defoliation, and reduced pending load. The management without plagiotropic branches showed higher harvesting efficiency, lower loss on the ground, and lower defoliation. Harvesting speeds from 800 to 1600 m h-1 reduced the total and unit costs up to 62% compared to manual harvesting. Increasing harvesting efficiency above 70% has reduced harvesting costs by up to 79% compared to manual harvesting.

Resumo Contra a vertente teórica das materialidades da comunicação, que se baseia no conceito de presença e na fisicalidade do suporte, este artigo pretende repensar o campo das materialidades propondo a passagem de uma lógica da presença para uma lógica da relação. Assim, trata-se de sugerir uma teoria da materialidade relacional. As implicações de tal possibilidade permitem não apenas uma crítica ao conceito de presença, mas também uma revisão da própria noção de intermidialidade. Para esse propósito, os aportes teóricos utilizados foram Marshall McLuhan, Richard Grusin, Jay Bolter e Gilles Deleuze. comunicação suporte relação Assim tratase trata relacional intermidialidade propósito McLuhan Grusin Deleuze

Abstract Against the theoretical strand of materialities of communication, which is based on the concept of presence and on the physicality of the apparatus, this paper intends to rethink materialities by proposing the transition from a logic of presence to a logic of relations. Thus, it is a matter of suggesting a theory of relational materiality. Such possibility implies not only a critique of the concept of presence, but also a re-examination of the very notion of intermediality. For this purpose, the theoretical contributions of Marshall McLuhan, Richard Grusin, Jay Bolter and Gilles Deleuze are used in this paper. communication apparatus relations Thus materiality reexamination re examination intermediality purpose McLuhan Grusin