Resumo Objetivo: Analisar a tendência temporal da cobertura da vacina contra o papilomavírus humano (human papillomavirus, ou HPV), na população feminina com idade de 10 a 14 anos, residente no estado de Goiás, Brasil, entre 2014 e 2022. Métodos: Estudo ecológico de série temporal com dados obtidos do Departamento de Informática do Sistema Único de Saúde (Datasus); calculou-se a taxa de cobertura vacinal anual considerando-se o número de segundas doses administradas; a tendência das taxas foi analisada utilizando-se o modelo de Prais-Winsten. Resultados: Foram aplicadas 407.217 segundas doses da vacina quadrivalente contra HPV na população feminina de 10-14 anos, com taxas de cobertura vacinal anual a variar entre 12,3% (2019) e 30,0% (2015), e uma variação percentual anual (VPA) de 0,7% (IC95% 0,9;0,2; p-valor = 0,030). Conclusão: Em Goiás, a taxa de cobertura da vacina quadrivalente contra HPV esteve aquém da meta nacional (80%), com tendência estacionária da série temporal.

Resumen Objetivo: Analizar la tendencia temporal de la cobertura de la vacuna contra el virus del papiloma humano (VPH), en la población femenina en Goiás, Brasil, entre 2014 y 2022. Métodos: Estudio de serie temporal con datos del Departamento de Informática del Sistema Único de Salud (Datasus); la tasa de cobertura vacunal anual fue calculada por el número de segundas dosis administradas y para el análisis de tendencias se utilizó Prais-Winsten. Resultados: Se administraron 407.217 segundas dosis de la vacuna tetravalente contra el VPH en la población femenina de 10 a 14 años en Goiás, con tasas de cobertura vacinal anual variando entre 12,3% (2019) y 30,0% (2015), y una variación porcentual anual (VPA) de 0,7% (IC95% 0,9;0,2; p-valor = 0,030). Conclusión: La tasa de cobertura de la vacuna tetravalente contra el VPH en Goiás quedó por debajo de la meta nacional (80%), con tendencia estacionaria en la serie temporal.

Abstract Objective: To analyze the temporal trend of human papillomavirus (HPV) vaccination coverage among the female population aged 10 to 14 years, living in the state of Goiás, Brazil, between 2014 and 2022. Methods: This was an ecological time series study using data from the Brazilian National Health System Information Technology Department (Departamento de Informática do Sistema Único de Saúde - DATASUS); the annual vaccination coverage rate was calculated based on the number of second doses administered; the trend of the rates was analyzed using the Prais-Winsten model. Results: A total of 407,217 second doses of the quadrivalent HPV vaccine were administered to the female population aged 10-14 years, with annual vaccination coverage rates ranging from 12.3% (2019) to 30.0% (2015), and an annual percentage change (APC) of 0.7% (95%CI 0.9; 0.2; p-value = 0.030). Conclusion: In Góias state, the quadrivalent HPV vaccine coverage rate was below the national target (80%), showing a stationary trend in the time series.

Abstract Background: Testosterone deficiency (TD) is a prevalent condition in our midst and still very neglected. Arterial hypertension (AH) is one of the possible associated factors. Objectives: To determine the prevalence of TD in a hypertensive male population and the factors associated with its occurrence, such as age, time since hypertension diagnosis, number of antihypertensive classes, body mass index (BMI), diabetes, dyslipidemia, chronic kidney disease (CKD), positive symptoms of TD (positive ADAM questionnaire) and use of spironolactone. Methods: Cross-sectional study with administration of the ADAM questionnaire, assessment of biochemical, clinical, and anthropometric data. Patients were stratified into DT and normal testosterone groups. Categorical variables were compared using the chi-squared test and continuous variables using the Mann-Witney test; variables with significance (p<0,05) were analyzed by multivariable linear regression. Results: The prevalence of TD was 26.36%. There was an association between TD and body mass index (BMI) (p=0.0007) but there was no association with age (p=0.0520), time of hypertension diagnosis (p=0.1418), number of classes of antihypertensive drugs (p=0.732), diabetes (p=0.1112); dyslipidemia (p=0.3888); CKD (p=0.3321); use of spironolactone (p=0.3546) or positive ADAM questionnaire (p=0.2483). Conclusions: TD was highly prevalent and positively associated with BMI. Total testosterone (TT) declined by 8.44ng/dL with a one unit increase in BMI and dropped by 3.79ng/dL with a one-year increase in age. Background (TD neglected AH (AH Objectives occurrence BMI, , CKD, (CKD) Methods Crosssectional Cross sectional biochemical clinical data groups chisquared chi squared MannWitney Mann Witney p<0,05 p005 p 0 05 (p<0,05 regression Results 2636 26 36 26.36% (BMI p=0.0007 p00007 0007 (p=0.0007 p=0.0520, p00520 p=0.0520 0520 (p=0.0520) p=0.1418, p01418 p=0.1418 1418 (p=0.1418) p=0.732, p0732 p=0.732 732 (p=0.732) p=0.1112 p01112 1112 (p=0.1112) p=0.3888 p03888 3888 (p=0.3888) p=0.3321 p03321 3321 (p=0.3321) p=0.3546 p03546 3546 (p=0.3546 p=0.2483. p02483 p=0.2483 . 2483 (p=0.2483) Conclusions TT (TT 844ngdL ngdL 8 44ng dL ng 379ngdL 3 79ng oneyear year (CKD p<0,0 p00 (p<0,0 263 2 26.36 p=0.000 p0000 000 (p=0.000 p0052 p=0.052 052 (p=0.0520 p0141 p=0.141 141 (p=0.1418 p073 p=0.73 73 (p=0.732 p=0.111 p0111 111 (p=0.1112 p=0.388 p0388 388 (p=0.3888 p=0.332 p0332 332 (p=0.3321 p=0.354 p0354 354 (p=0.354 p0248 p=0.248 248 (p=0.2483 p<0, p0 (p<0, 26.3 p=0.00 p000 00 (p=0.00 p=0.05 (p=0.052 p014 p=0.14 14 (p=0.141 p07 p=0.7 7 (p=0.73 p=0.11 p011 11 (p=0.111 p=0.38 p038 38 (p=0.388 p=0.33 p033 33 (p=0.332 p=0.35 p035 35 (p=0.35 p024 p=0.24 24 (p=0.248 p<0 (p<0 26. p=0.0 (p=0.0 (p=0.05 p01 p=0.1 1 (p=0.14 p=0. (p=0.7 (p=0.11 p=0.3 p03 (p=0.38 (p=0.33 (p=0.3 p02 p=0.2 (p=0.24 p< (p< (p=0. (p=0.1 p=0 (p=0.2 (p (p=0 p= (p=

Resumo Fundamento: A deficiência de testosterona (DT) é uma condição prevalente em nosso meio e ainda muito negligenciada. A hipertensão arterial (HA) é um de seus possíveis fatores associados. Objetivos: Determinar a prevalência de DT em uma população masculina hipertensa e os fatores associados à sua ocorrência, como idade, tempo de diagnóstico de HA, número de classes de anti-hipertensivos, índice de massa corporal (IMC), diabetes, dislipidemia, doença renal crônica (DRC), sintomas positivos de DT (questionário ADAM positivo) e uso de espironolactona. Métodos: Estudo transversal com aplicação do questionário ADAM, e avaliação de dados bioquímicos, clínicos e antropométricos. Os pacientes foram estratificados em grupos de DT e testosterona normal. As variáveis categóricas foram comparadas pelo teste do qui-quadrado e as variáveis contínuas pelo teste de Mann-Witney; as variáveis com significância (p<0,05) foram submetidas à regressão linear multivariada. Resultados: A prevalência de DT foi de 26,8%. Houve associação entre DT e IMC (p=0,0007), mas não houve com idade (p=0,0520), tempo de diagnóstico de HA (p=0,1418), número de classes de anti-hipertensivos (p=0,0732), diabetes (p=0,1112); dislipidemia (p=0,3888); presença de DRC (p=0,3321); uso de espironolactona (p=0,3546) e questionário ADAM positivo (p=0,2483). Conclusões: A prevalência de DT foi alta e houve associação positiva com IMC. A testosterona total (TT) declinou 8,44 ng/dL com o aumento de 1 kg/m2 no IMC e caiu 3,79 ng/dL com o avanço em um ano na idade. Fundamento (DT negligenciada (HA Objetivos ocorrência antihipertensivos, antihipertensivos anti hipertensivos, hipertensivos IMC, , (IMC) DRC, (DRC) Métodos bioquímicos antropométricos normal quiquadrado qui quadrado MannWitney Mann Witney Mann-Witney p<0,05 p005 p 0 05 (p<0,05 multivariada Resultados 268 26 8 26,8% p=0,0007, p00007 p=0,0007 0007 (p=0,0007) p=0,0520, p00520 p=0,0520 0520 (p=0,0520) p=0,1418, p01418 p=0,1418 1418 (p=0,1418) p=0,0732, p00732 p=0,0732 0732 (p=0,0732) p=0,1112 p01112 1112 (p=0,1112) p=0,3888 p03888 3888 (p=0,3888) p=0,3321 p03321 3321 (p=0,3321) p=0,3546 p03546 3546 (p=0,3546 p=0,2483. p02483 p=0,2483 . 2483 (p=0,2483) Conclusões TT (TT 844 44 8,4 ngdL ng dL kgm2 kgm kg m2 m kg/m 379 3 79 3,7 (IMC (DRC p<0,0 p00 (p<0,0 2 26,8 p0000 p=0,000 000 (p=0,0007 p0052 p=0,052 052 (p=0,0520 p0141 p=0,141 141 (p=0,1418 p0073 p=0,073 073 (p=0,0732 p=0,111 p0111 111 (p=0,1112 p=0,388 p0388 388 (p=0,3888 p=0,332 p0332 332 (p=0,3321 p=0,354 p0354 354 (p=0,354 p0248 p=0,248 248 (p=0,2483 84 4 8, 37 7 3, p<0, p0 (p<0, 26, p000 p=0,00 00 (p=0,000 p=0,05 (p=0,052 p014 p=0,14 14 (p=0,141 p007 p=0,07 07 (p=0,073 p=0,11 p011 11 (p=0,111 p=0,38 p038 38 (p=0,388 p=0,33 p033 33 (p=0,332 p=0,35 p035 35 (p=0,35 p024 p=0,24 24 (p=0,248 p<0 (p<0 p=0,0 (p=0,00 (p=0,05 p01 p=0,1 (p=0,14 (p=0,07 (p=0,11 p=0,3 p03 (p=0,38 (p=0,33 (p=0,3 p02 p=0,2 (p=0,24 p< (p< p=0, (p=0,0 (p=0,1 (p=0, (p=0,2 (p p=0 (p=0 p= (p=

Abstract Objective: This systematic review accompanied by a meta-analysis aimed to estimate the prevalence of syphilis in pregnant women in Brazil and describe its associated factors. Methods: Following the establishment the search strategies and the registration of the review protocol in PROSPERO, we conducted a search for relevant articles in the Pubmed, LILACS, Science Direct, SciELO and Web of Science databases. Our inclusion criteria were cross-sectional studies published between 2005 and 2023, with no language restrictions. The combined prevalence of syphilis infection was estimated using the random effects model in the R Software with a 95% confidence interval (95% CI) and p < 0.01 as statistically significant. Results: A total of 24 articles were recruited, which together investigated 221,884 women. The combined prevalence of syphilis in pregnant women in Brazil was 1.79% (95% CI: 1.24-2.57%), and the main factors associated with its occurrence were black and brown skin color, low education and factors related to the partner. Conclusion: There was a high prevalence of syphilis in pregnancy in Brazil, mainly associated with socioeconomic factors. Objective metaanalysis meta analysis Methods PROSPERO Pubmed LILACS Direct databases crosssectional cross sectional 200 2023 restrictions 95 (95 CI 001 0 01 0.0 significant Results 2 recruited 221884 221 884 221,88 179 1 79 1.79 1.242.57%, 124257 1.24 2.57% , 57 1.24-2.57%) color partner Conclusion 20 202 9 (9 00 0. 22188 22 88 221,8 17 7 1.7 242 1.242.57% 12425 124 1.2 257 2.57 5 1.24-2.57% ( 2218 8 221, 1. 1.242.57 1242 12 25 2.5 1.24-2.57 1.242.5 2. 1.24-2.5 1.242. 1.24-2. 1.242 1.24-2 1.24-

Abstract Objective: To analyze the temporal trend of human papillomavirus (HPV) vaccination coverage among the female population aged 10 to 14 years, living in the state of Goiás, Brazil, between 2014 and 2022. Methods: This was an ecological time series study using data from the Brazilian National Health System Information Technology Department (Departamento de Informática do Sistema Único de Saúde - DATASUS); the annual vaccination coverage rate was calculated based on the number of second doses administered; the trend of the rates was analyzed using the Prais-Winsten model. Results: A total of 407,217 second doses of the quadrivalent HPV vaccine were administered to the female population aged 10-14 years, with annual vaccination coverage rates ranging from 12.3% (2019) to 30.0% (2015), and an annual percentage change (APC) of 0.7% (95%CI 0.9; 0.2; p-value = 0.030). Conclusion: In Góias state, the quadrivalent HPV vaccine coverage rate was below the national target (80%), showing a stationary trend in the time series. Objective (HPV 1 years Goiás Brazil 201 2022 Methods Departamento DATASUS DATASUS) PraisWinsten Prais Winsten model Results 407217 407 217 407,21 1014 10-1 123 12 3 12.3 2019 (2019 300 30 0 30.0 2015, 2015 , (2015) APC (APC 07 7 0.7 95%CI 95CI CI 95 0.9 09 9 0.2 02 2 pvalue p value 0.030. 0030 0.030 . 030 0.030) Conclusion 80%, 80 80% (80%) 20 202 40721 40 21 407,2 101 10- 12. (201 30. (2015 0. 003 0.03 03 8 (80% 4072 4 407, (20 00 0.0 (80 (2 (8 (

Resumo Objetivo: Analisar a tendência temporal da cobertura da vacina contra o papilomavírus humano (human papillomavirus, ou HPV), na população feminina com idade de 10 a 14 anos, residente no estado de Goiás, Brasil, entre 2014 e 2022. Métodos: Estudo ecológico de série temporal com dados obtidos do Departamento de Informática do Sistema Único de Saúde (Datasus); calculou-se a taxa de cobertura vacinal anual considerando-se o número de segundas doses administradas; a tendência das taxas foi analisada utilizando-se o modelo de Prais-Winsten. Resultados: Foram aplicadas 407.217 segundas doses da vacina quadrivalente contra HPV na população feminina de 10-14 anos, com taxas de cobertura vacinal anual a variar entre 12,3% (2019) e 30,0% (2015), e uma variação percentual anual (VPA) de 0,7% (IC95% 0,9;0,2; p-valor = 0,030). Conclusão: Em Goiás, a taxa de cobertura da vacina quadrivalente contra HPV esteve aquém da meta nacional (80%), com tendência estacionária da série temporal. Objetivo human papillomavirus HPV, , HPV) 1 anos Goiás Brasil 201 2022 Métodos Datasus (Datasus) calculouse calculou se considerandose considerando administradas utilizandose utilizando PraisWinsten. PraisWinsten Prais Winsten. Winsten Prais-Winsten Resultados 407217 407 217 407.21 1014 10-1 123 12 3 12,3 2019 (2019 300 30 0 30,0 2015, 2015 (2015) VPA (VPA 07 7 0,7 IC95% IC95 IC (IC95 0,90,2 0902 0,9 0,2 9 2 0,9;0,2 pvalor p valor 0,030. 0030 0,030 . 030 0,030) Conclusão 80%, 80 80% (80%) 20 202 (Datasus 40721 40 21 407.2 101 10- 12, (201 30, (2015 0, IC9 (IC9 90 0,90, 090 09 02 0,9;0, 003 0,03 03 8 (80% 4072 4 407. (20 (IC 0,90 0,9;0 00 0,0 (80 (2 0,9; (8 (

Resumen Objetivo: Analizar la tendencia temporal de la cobertura de la vacuna contra el virus del papiloma humano (VPH), en la población femenina en Goiás, Brasil, entre 2014 y 2022. Métodos: Estudio de serie temporal con datos del Departamento de Informática del Sistema Único de Salud (Datasus); la tasa de cobertura vacunal anual fue calculada por el número de segundas dosis administradas y para el análisis de tendencias se utilizó Prais-Winsten. Resultados: Se administraron 407.217 segundas dosis de la vacuna tetravalente contra el VPH en la población femenina de 10 a 14 años en Goiás, con tasas de cobertura vacinal anual variando entre 12,3% (2019) y 30,0% (2015), y una variación porcentual anual (VPA) de 0,7% (IC95% 0,9;0,2; p-valor = 0,030). Conclusión: La tasa de cobertura de la vacuna tetravalente contra el VPH en Goiás quedó por debajo de la meta nacional (80%), con tendencia estacionaria en la serie temporal. Objetivo VPH, , (VPH) Brasil 201 2022 Métodos Datasus (Datasus) PraisWinsten. PraisWinsten Prais Winsten. Winsten Prais-Winsten Resultados 407217 407 217 407.21 1 123 12 3 12,3 2019 (2019 300 30 0 30,0 2015, 2015 (2015) VPA (VPA 07 7 0,7 IC95% IC95 IC (IC95 0,90,2 0902 0,9 0,2 9 2 0,9;0,2 pvalor p valor 0,030. 0030 0,030 . 030 0,030) Conclusión 80%, 80 80% (80%) (VPH 20 202 (Datasus 40721 40 21 407.2 12, (201 30, (2015 0, IC9 (IC9 90 0,90, 090 09 02 0,9;0, 003 0,03 03 8 (80% 4072 4 407. (20 (IC 0,90 0,9;0 00 0,0 (80 (2 0,9; (8 (

ABSTRACT BACKGROUND: The largest radiological accident to occur in any urban area happened in Goiânia, Brazil, in 1987. OBJECTIVE: To evaluate the association between breast cancer incidence and ionizing radiation levels. DESIGN AND SETTING: Ecological study among residents of the city of Goiânia, Brazil. METHODS: The central region of Goiânia, with seven major sources of contamination from cesium-137, was defined as the study area. The addresses of women diagnosed with breast cancer were identified between 2001 and 2010. The data were geographically referenced and, using census data, the annual averages of crude incidence rates were estimated. The existence of clusters of new cases was ascertained by means of the Moran index. Correlations of radiometric measurements with the incidence were assessed using unconditional linear regression. RESULTS: A total of 4,105 new cases were identified, of which 2,233 were in the study area, and of these, 1,286 (57.59%) were georeferenced. The gross rates of total and referenced cases were 102.91 and 71.86/100,000 women, respectively. These were close to the average for Brazilian state capitals, which is 79.37/100,000 women. The cluster analysis showed slight correlations in three small sets of census tracts, but these were far from the sources of contamination. The scatter plot of points and the R2 value close to zero indicated that there was no association between the variables. CONCLUSION: This study reinforces the hypothesis that the ionizing radiation levels to which women living in Goiânia are now exposed to are not associated with the onset of new cases of breast cancer.

RESUMO Objetivo: avaliar o perfil de segurança e os resultados estéticos do 2-octilcianoacrilato versus sutura intradérmica com fio de nylon em cirurgias mamárias. Métodos: ensaio clínico randomizado, aberto, que avaliou a ocorrência de complicações, como deiscência, hematoma, infecção e reações alérgicas após o uso do 2-octilcianoacrilato ou do fio de nylon. Também foi analisado o tamanho das incisões, o tempo de fechamento da pele e o tempo cirúrgico total. O resultado estético foi avaliado após 40 e 180 dias da cirurgia, por meio da largura média da ferida operatória e por avaliação subjetiva conceitual (ótimo, bom, razoável ou ruim). Resultados: foram incluídas 79 pacientes, sendo 37 no grupo 2-octilcianoacrilato e 42 no grupo de sutura com fio de nylon. O estudo foi interrompido antes do término do recrutamento dos pacientes pela ocorrência de maior número de deiscências no grupo do adesivo (OR: 11,42; IC95%: 1,36-96,02; p=0,007). Em relação às demais complicações analisadas, ao tempo cirúrgico e ao resultado estético no pós-operatório, não se observaram diferenças significativas entre os grupos. A média do tamanho da ferida operatória foi maior no grupo do adesivo em relação ao grupo da sutura, mas não houve correlação entre o tamanho da ferida e o maior número de deiscências. Conclusão: o 2-octilcianoacrilato apresentou maior risco de deiscência em relação à sutura intradérmica, com resultados estéticos equivalentes.

ABSTRACT Objective: to evaluate the safety profile and aesthetic results of 2-octyl-cyanoacrylate versus intradermal nylon suture in breast surgeries. Methods: an open-label, randomized, clinical trial evaluating the occurrence of complications, such as dehiscence, hematoma, infection, and allergic reactions after the use of 2-octyl-cyanoacrylate or nylon thread. The size of the incisions, skin closure time, and total surgical time were also analyzed. The aesthetic outcome was evaluated at 40 and 180 days after surgery, by means of the average width of the surgical wound and by subjective conceptual assessment (optimal, good, reasonable, or poor). Results: 79 patients were included: 37 in the 2-octyl-cyanoacrylate group and 42 in the nylon suture group. The study was stopped before the end of patient recruitment due to the occurrence of a greater number of dehiscences in the adhesive group (OR: 11.42; 95%CI: 1.36-96.02; p=0.007). Regarding the other analyzed complications, the surgical duration and postoperative aesthetic result, no significant differences were observed between the groups. The mean operative wound size was greater in the adhesive group than in the suture group, but there was no correlation between wound size and the largest number of dehiscences. Conclusion: while the cosmetic outcomes with the two techniques were similar, there was a greater risk of dehiscence with the use of 2-octyl-cyanoacrylate compared to intradermal suturing.

RESUMO Objetivo: analisar a sobrevida global e os fatores prognósticos de mulheres com câncer de mama na cidade de Goiânia. Métodos: estudo observacional, retrospectivo, transversal, que incluiu mulheres portadoras de neoplasias malignas da mama identificadas pelo Registro de Câncer de Base Populacional de Goiânia. As variáveis estudadas foram: idade ao diagnóstico, tamanho do tumor, estadiamento, comprometimento dos linfonodos axilares, grau tumoral, extensão da doença, receptores hormonais e oncoproteína c-erb-B2. Foram realizadas análises de sobrevida global, de cinco e de dez anos. Resultados: foram incluídas no estudo 2273 pacientes, com sobrevida global em cinco anos de 72,1% e de 57,8% em dez anos. Na análise multivariada ajustada pelo tamanho do tumor, os fatores que influenciaram o prognóstico foram: linfonodos axilares, grau histológico, receptor de progesterona, c-erb-B2, estadiamento T e extensão da doença. Conclusão: a sobrevida global em dez anos está abaixo da observada em outros países, e possivelmente reflete o que acontece com a maioria da população brasileira. Os fatores prognósticos encontrados nesta população seguem o mesmo padrão internacional.

ABSTRACT Objective: to analyze the overall survival and prognostic factors of women with breast cancer in the city of Goiânia. Methods: this is a retrospective, cross-sectional, observational study that included women with malignant neoplasms of the breast identified by the Goiânia Population-based Cancer Registry. The variables studied were age at diagnosis, tumor size, staging, axillary lymph node involvement, tumor grade, disease extent, hormone receptors, and c-erb-B2 oncoprotein. We performed overall survival analyzes of five and ten years. Results: we included 2,273 patients in the study, with an overall survival of 72.1% in five years and 57.8% in ten years. In the multivariate analysis adjusted for tumor size, the factors that influenced the prognosis were axillary lymph nodes, histological grade, progesterone receptor, c erb B2, T staging and disease extension. Conclusion: overall survival in ten years is below that observed in other countries, and possibly reflects what happens with the majority of the Brazilian population. The prognostic factors found in this population follow the same international patterns.

OBJECTIVE: This randomized clinical trial evaluated the possibility of not draining the axilla following axillary dissection. METHODS: The study included 240 breast cancer patients who underwent axillary dissection as part of conservative treatment. The patients were divided into two groups depending on whether or not they were subjected to axillary drainage. ClinicalTrials.gov: NCT01267552. RESULTS: The median volume of fluid aspirated was significantly lower in the axillary drainage group (0.00 ml; 0.00 - 270.00) compared to the no drain group (522.50 ml; 130.00 - 1148.75). The median number of aspirations performed during conservative breast cancer treatment was significantly lower in the drainage group (0.5; 0.0 - 4.0) compared to the no drain group (5.0; 3.0 - 7.0). The total volume of serous fluid produced (the volume of fluid obtained from drainage added to the volume of aspirated fluid) was similar in the two groups. Regarding complications, two cases (2.4%) of wound dehiscence occurred in the drainage group compared to 13 cases (13.5%) in the group in which drainage was not performed, with this difference being statistically significant. Rates of infection, necrosis and hematoma were similar in both groups. CONCLUSION: Safety rates were similar in both study groups; hence, axillary dissection can feasibly be performed without drainage. However, more needle aspirations could be required, and there could be more cases of wound dehiscence in patients who do not undergo auxiliary drainage.

ABSTRACT PURPOSE: To investigate if the association of fat grafts and platelet-rich plasma (PRP) improves graft viability in female rats. METHODS: This is an experimental, randomized and blinded study, which involved 47 rats. Fat was harvested from the inguinal region and grafted to the cranial region. The experimental group consisted of PRP-enriched fat grafts (n=22) whilst the control group consisted of fat graft only (n=25). After a 100-day period, the animals were euthanised and the fat grafts were analyzed using scores from 0 (absent) to 4 (abundant), in optical microscopy by two independent and blinded pathologists. RESULTS: Regarding fat graft cell viability, the PRP group scored moderate/abundant in 63% of cases and the fat graft only group scored absent/slight in 72% of cases (p=0.03). The PRP group also presented lower fat necrosis scores when compared to the fat graft only group (p=0.03). Tumors (dermoid cysts) within the fat grafts were observed in three animals in which the grafts were mixed with PRP. CONCLUSION: Platelet-rich plasma improves the viability and integration of fat grafts in rats, but more studies are needed to fully understand the exact mechanisms that lead to this improvement and assess the safety of the method for use in humans.

<sec><title>OBJETIVO:</title><p> Descrever a mortalidade por câncer de mama feminino no Brasil segundo a cor, nos anos de 2000 e 2010.</p></sec><sec><title>MÉTODOS:</title><p> Estudo descritivo, no qual os dados populacionais foram obtidos do Instituto Brasileiro de Geografia e Estatística (IBGE). As informações de óbitos por câncer de mama foram coletadas do Ministério da Saúde, através do Sistema de Informações sobre Mortalidade (SIM). Foram calculadas as taxas de mortalidade bruta por câncer de mama feminino de acordo com a cor e o grupo etário, até 49 anos ou ≥ 50 anos. Os resultados foram também avaliados pelas cinco macrorregiões do país (Norte, Nordeste, Centro-Oeste, Sul e Sudeste).</p></sec><sec><title>RESULTADOS:</title><p> No Brasil, em mulheres com 50 anos ou mais, as maiores taxas brutas de mortalidade por câncer de mama em 2000 foram de 62,6/100.000, 46,0/100.000 e 29,7/100.000, entre amarelas, brancas e pretas, respectivamente. Nas mulheres com menos de 50 anos, em 2000, a mortalidade bruta variou de 2,0/100.000 entre as indígenas a 6,8/100.000 entre as mulheres brancas. Após dez anos, em mulheres com idade superior a 50 anos, a taxa bruta de mortalidade entre amarelas, brancas e pretas foi de 21,5, 53,2 e 40,4 por 100.000, respectivamente. Nas macrorregiões do país, as maiores taxas de mortalidade por câncer de mama foram observadas nas mulheres brancas e pretas das regiões Sul e Sudeste. No Nordeste, as taxas de mortalidade em mulheres pretas e pardas dobraram em 2010.</p></sec><sec><title>CONCLUSÃO:</title><p> As taxas de mortalidade por câncer de mama apresentam variações étnicas e geográficas. Entretanto, não se pode excluir a possibilidade de que grandes variações tenham ocorrido em decorrência de melhoria na qualidade da informação sobre a mortalidade no país.</p></sec>

<sec><title>PURPOSE:</title><p> To describe the mortality of female breast cancer in Brazil according to color, in the years 2000 and 2010.</p></sec><sec><title>METHODS:</title><p> A descriptive study in which demographic data were obtained from the Brazilian Institute of Geography and Statistics (IBGE). The breast cancer death information in Brazil was collected from the Ministry of Health through the Mortality Information System (SIM). The crude mortality rates for female breast cancer were calculated according to color and age group, up to 49 years and ≥50 years. The results obtained were distributed into five geographical regions of the country (North, Northeast, Midwest, South and Southeast).</p></sec><sec><title>RESULTS:</title><p> In Brazil, in women aged 50 or more, the highest crude mortality rates of breast cancer in 2000 were 62.6/100,000, 46.0/100,000 and 29.7/100,000 among yellow, white and black women, respectively. In women under 50 years in 2000, the crude mortality ranged from 2.0/100,000 among indigenous women to 6.8/100,000 among white women. After ten years, in women over 50 years, the crude mortality rate among yellow, white and black women was 21.5, 53.2 and 40.4 per 100,000, respectively. In the country's regions, the highest mortality rates of breast cancer were observed in white and black women from the South and Southeast. In the Northeast, mortality rates in black and brown women doubled in 2010.</p></sec><sec><title>CONCLUSION:</title><p> Breast cancer mortality rates show ethnic and geographical variations. However, it is not possible to exclude the possibility that large variations have occurred as a result of improvement in the quality of information on mortality in the country.</p></sec>

Este estudo objetivou descrever e analisar a prevalência de burnout e pensamentos suicidas em médicos residentes de um hospital público de Goiânia e verificar se há correlação entre os dois. Foi realizada uma investigação por meio de um estudo analítico-descritivo em corte transversal em 72 residentes através do MBI (Malasch Burnout Inventory) e do questionário de suicídio de Paykel. Este estudo foi aprovado pelo Comitê de Ética em Pesquisa do Hospital das Clínicas da Universidade Federal de Goiás sob o Parecer nº 052/2009. Resultados indicam a prevalência de burnout em 18,05% da amostra. Dentre os 13 sujeitos com manifestação de burnout, 61,53% já apresentaram pensamentos suicidas. Dentre os 42 sujeitos com baixo risco para manifestação de burnout, 28,57% já apresentaram pensamentos suicidas. Evidenciou-se correlação entre burnout e pensamentos suicidas, o que torna preciso elaborar programas de prevenção do burnout. Pesquisas nesta área são necessárias para a compreensão do burnout e sua correlação com pensamentos suicidas e outros distúrbios psiquiátricos.

This study aimed to analyze the prevalence of burnout and suicidal thoughts in residents of a public hospital in Goiania and to verify if there is any correlation between the two. An investigation was conducted using an analytic-descriptive cross-sectional study among 72 residents using the MBI (Malasch Burnout Inventory) and the Paykel's suicide questionnaire. This study was approved by the Ethics Committee of the Hospital das Clínicas of GoiásFederal University, under registration number 052/2009. The results show the prevalence of burnout in 18.05% of the sample. Among the 13 subjects who displayed 'burnout', 61.53% have had suicidal thoughts. Among the other 42 with low risk for manifestation of 'burnout', 28.57% have had suicidal thoughts. This study revealed a correlation between 'burnout' and suicidal thoughts, making it necessary to draw up burnout prevention programs. Research hasbecome necessary for the understanding of burnout and its correlation tosuicidal thoughts and other psychiatric disorders.