SUMMARY OBJECTIVE: The aim of this study was to assess obstetric and perinatal outcomes in women with hyperprolactinemia according to the type of treatment indicated, with cabergoline or bromocriptine. METHODS: A retrospective cohort study with 464 women diagnosed with hyperprolactinemia was undertaken at the endocrine gynecology outpatient clinic of a tertiary hospital from May 2002 to February 2022. All women diagnosed with hyperprolactinemia who were being treated with dopamine agonists (cabergoline or bromocriptine) and who became pregnant during the follow-up were included. Women whose medical records did not provide data related to pregnancy and delivery were excluded. The women were divided into two groups according to the type of treatment: bromocriptine or cabergoline. Clinical and laboratory characteristics and obstetric and perinatal outcomes, such as complications during pregnancy, type of delivery, and intrapartum complications, were evaluated in both groups. RESULTS: Of the 464 women evaluated, 72 became pregnant during the follow-up, 66 of them were using dopamine agonists, while 6 were not using medication. The mean age of the women was 28.3±6.8 years. Among the causes of hyperprolactinemia, 48.6% were idiopathic, 45.7% were tumoral, and 3.7% had other causes. Most women with idiopathic hyperprolactinemia used bromocriptine, while those with tumoral hyperprolactinemia used cabergoline (p=0.04). There was no difference in obstetric outcomes according to the type of treatment used. The majority of women did not have any complications during pregnancy (76.3%) or intrapartum (86.8%). CONCLUSION: Regardless of the type of previous drug treatment with dopamine agonists, hyperprolactinemia does not alter obstetric outcomes. OBJECTIVE indicated METHODS 46 200 2022 followup follow up included excluded RESULTS 7 followup, up, medication 28368 28 3 8 28.3±6. years 486 48 48.6 457 45 45.7 37 3.7 p=0.04. p004 p p=0.04 . 0 04 (p=0.04) 76.3% 763 76 (76.3% 86.8%. 868 86.8% 86 (86.8%) CONCLUSION 4 20 202 2836 2 28.3±6 48. 45. 3. p00 p=0.0 (p=0.04 76.3 (76.3 86.8 (86.8% 283 28.3± p0 p=0. (p=0.0 76. (76. 86. (86.8 28.3 p=0 (p=0. (76 (86. 28. p= (p=0 (7 (86 (p= ( (8 (p

Abstract The objective of the article is to present a discussion about the methodological difficulties faced in carrying out research on the identification of criminal suspects in Brazil - a practice known as “founded suspicion”, provided for in art. 244 of the Criminal Procedure Code - especially studies aimed at understanding such identification as racially discriminatory. Comparing how this debate emerged in the United States, we question the reasons why this topic faced impasses in forming a research agenda in the country, in addition to pointing out the strategies used by Brazilian researchers to address such issues. Aiming to overcome these shortcomings, in the article we propose new possibilities for using methodologies to carry out these studies, deepening the analysis of how other actors in the criminal justice system - in addition to the police - also reproduce a discriminatory standard narrative about these cases. founded suspicion, suspicion , suspicion” art 24 States country issues shortcomings cases 2

Resumo O objetivo do artigo é apresentar uma discussão sobre as dificuldades metodológicas enfrentadas para se realizar pesquisas sobre a identificação de suspeitos criminais no Brasil - prática conhecida como “fundada suspeita”, prevista no art. 244 do CPP - em especial aquelas voltadas a compreendê-la como racialmente discriminatória. Fazendo uma comparação em como esse debate surgiu nos Estados Unidos, questionamos os motivos pelos quais esse tema enfrentou impasses para formar uma agenda de pesquisa no país, além de apontar as estratégias utilizadas por pesquisadores brasileiros para abordar tais assuntos. Visando superar esses impasses, propomos no artigo novas possibilidades de utilização de metodologias para realização das pesquisas, voltadas a aprofundar a análise sobre como outros atores do sistema de justiça criminal - além da polícia - também reproduzem uma narrativa-padrão e discriminatória sobre esses casos. fundada suspeita, suspeita , suspeita” art 24 compreendêla compreendê la Unidos país assuntos narrativapadrão narrativa padrão casos 2

BACKGROUND: Ankylosing spondylitis (AS) is characterised as a chronic inflammatory disease of the axial skeleton. The force platform is an option for performing the postural assessment of these individuals OBJECTIVES: To review and evaluate the behaviour of the centre of pressure (CoP) variables during the postural control examination in patients with AS compared to a control group METHOD: A systematic review, registered in PROSPERO, that followed the PRISMA Statement. A search was carried out in the following databases: Medline, Web of Science, Embase, Scopus, and Scielo, from 1945 to 2023. Studies were selected that aimed to understand the use of the force platform for the assessment of postural control. The risk of bias assessment was performed using the AXIS tool RESULTS: Five studies were included, with a total of 247 participants. The assessment of risk of bias presented high scores in the AXIS tool. Patients with a diagnosis of AS presented increased thoracic kyphosis in most of the studies, as well as large displacements in the anteroposterior (AP) and mediolateral (ML) directions, and altered total mean velocity (TMV) and frequency, indicating worse postural stability. Regarding the functional status, the most used questionnaires were the Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Metrology Index (BASMI) and Bath Ankylosing Disease Activity Index (BASDAI CONCLUSION: Patients with ankylosing spondylitis present postural instability, verified by means of higher values of centre of posture variables CLINICAL IMPLICATIONS: Individuals with ankylosing spondylitis presented postural instability and balance deficit. Therefore, exercises for balance training and postural control are essential in the clinical management of these patients

Abstract In this paper, the application of AI and machine learning (ML) to the study of wireless propagation channels is investigated in two parts: first, an artificial neural network model is used to improve path loss prediction, and then, a pattern recognition model using multilayer perceptron (MLP) networks is used to identify and remove impulsive noise in power delay profiles (PDP). These studies were conducted based on field measurements in the 2400 MHz band in a public square with vegetation. The results are analyzed and compared with ordinary least squares (OLS) nonlinear regression results and results from similar studies. The Root Mean Square Error (RMSE) values between the experimental results of mean path loss and those provided by each propagation model are presented. The adjustment performed by OLS nonlinear regression and ANN significantly reduced the RMSE. The best results are those presented by artificial neural networks, with RMSE of 0.39 when using four neurons in the hidden layer of the ANN. The ANN used to identify and remove impulsive noise in power delay profiles (PDP) through pattern recognition proved to be more efficient than the CFAR technique. ANN technique found a larger number of valid multipaths compared to the CFAR technique. paper ML (ML parts first prediction then MLP (MLP PDP. PDP . 240 vegetation (OLS (RMSE 039 0 39 0.3 (PDP 24 03 3 0. 2

Poly(3-decylthiophene) is a polymer with conductive characteristics due to its conjugated polymeric chain. With the search for new applications and improvements of these materials, in sensors, and OPVs, there is a great demand for deeper knowledge about them. This work aims to characterize the P3DT, through analysis of optoelectrical measurements. Using the drop casting technique, thin films were made onto solid substrates. The films were subjected to optical characterization by UV-Vis and optical microscopy. The electrical characterization was obtained by IxV curves and then measuring the photoconductivity through Ixt curves, with a solar simulator. With UV-Vis measurements, it was observed that the absorption of light in the visible spectrum reached a peak of 520 nm in the film, blue-shifted in the solution attributed to the differences in the organization of the polymer chains. The optical microscopy measurements indicate the formation of aggregates with a higher concentration of aggregates observed for the film obtained with a more concentrated solution. Finally, the photoconductivity measurements carried out obtained a positive response to the photo-excitation of the material due to exposure to light, with an increase in current in the film as the photo-exposure cycles were repeated. Poly3decylthiophene Polydecylthiophene Poly 3 decylthiophene Poly(3-decylthiophene chain materials sensors OPVs them P3DT PDT P DT technique substrates UVVis UV Vis simulator 52 blueshifted blue shifted chains Finally photoexcitation photo excitation photoexposure repeated 5

Abstract This study evaluated the effects of ora-pro-nobis (Pereskia aculeate) flour supplementation on the in vivo basal antioxidant system of Drosophila melanogaster, and its action on the neural modulation observed by the enzyme acetylcholinesterase (AChE). The flies will receive a standard diet with flour incorporated at 5, 10 and 20% for 7 days. There was no change in food consumption, body weight, protein thiol levels and negative geotaxis behavior. The flies showed a reduction in the basal production of reactive species at concentrations of 10 and 20%, while there was a reduction in lipid peroxidation and catalase activity at all concentrations, accompanied by an increase in the levels of non-protein thiols. Superoxide dismutase activity was reduced in the 5 and 20% groups, while the reduction of superoxide anion in the 10% group may have contributed to the increase in longevity also in the 10% group. Longevity increased in groups 5 and 10%. The open field test may be related to the reduction in AChE activity in the 5, 10 and 20% groups. In general, the data show that supplementation with ora-pro-nobis flour at the concentrations tested did not cause toxicity and modulated the cholinergic system, demonstrating a therapeutic potential. orapronobis ora pro nobis Pereskia aculeate melanogaster AChE. . (AChE) 1 20 days consumption weight behavior nonprotein non thiols general potential (AChE 2

Resumo Objetivos Fazer uma revisão sistemática da literatura sobre a anatomia dos ligamentos meniscotibiais (LMTs) mediais, e apresentar os achados mais aceitos e a evolução das informações anatômicas sobre essa estrutura. Materiais e Métodos A busca eletrônica foi realizada nos bancos de dados MEDLINE/PubMed, Google Scholar, EMBASE e Cochrane, sem restrições de data. Os seguintes termos de indexação foram utilizados: anatomy AND meniscotibial AND ligament AND medial. A revisão seguiu as recomendações da declaração de Principais Itens para Relatar Revisões Sistemáticas e Metanálises (Preferred Reporting Items for Systematic Reviews and Meta-Analyses, PRISMA, em inglês). Foram incluídos estudos anatômicos do joelho, como dissecções de cadáveres, investigações histológicas e/ou biológicas, e/ou imagens da anatomia do LMT medial. Resultados Oito artigos atenderam aos critérios de inclusão e foram selecionados. O primeiro foi publicado em 1984, e o último, em 2020. A amostra total nos 8 artigos foi de 96 pacientes. A maioria dos estudos é puramente descritiva em relação aos achados morfológicos macroscópicos e histológicos microscópicos. Dois estudos avaliaram os aspectos biomecânicos do LMT, e um analisou a correlação anatômica com o exame de ressonância magnética. Conclusão A principal função do LMT medial, ligamento que se origina na tíbia e se insere no menisco inferior, é estabilizar e manter a posição do menisco no platô tibial. LMTs (LMTs mediais estrutura MEDLINEPubMed MEDLINE PubMed MEDLINE/PubMed Scholar Cochrane data utilizados medial Preferred MetaAnalyses, MetaAnalyses Meta Analyses, Analyses Meta-Analyses PRISMA inglês. inglês . inglês) joelho cadáveres eou ou biológicas selecionados 1984 último 2020 9 pacientes microscópicos magnética inferior tibial 198 202 19 20 1 2

Abstract Objectives To perform a systematic review of the literature on the anatomy of the medial meniscotibial ligaments (MTLs), and to present the most accepted findings, as well as the evolution of the anatomical knowledge on this structure. Materials and Methods An electronic search was conducted in the MEDLINE/PubMed, Google Scholar, EMBASE and Cochrane library databases with no date restrictions. The following index terms were used in the search: anatomy AND meniscotibial AND ligament AND medial. The review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. We included anatomical studies of the knee were included, such as cadaver dissections, histological and/or biological investigations, and/or imaging of the medial MTL anatomy. Results Eight articles that met the inclusion criteria were selected. The first article was published in 1984 and the last, in 2020. The total sample in the 8 articles was of 96 patients. Most studies are purely descriptive in terms of the macroscopic morphological and microscopic histological findings. Two studies evaluated the biomechanical aspects of the MTL, and one, the anatomical correlation with the magnetic resonance imaging examination. Conclusion The main function of the medial MTL, a ligament that originates in the tibia and is inserted in the lower meniscus, is to stabilize and maintain the meniscus in its position on the tibial plateau. However, there is a limited amount of information regarding medial MTLs, primarily in terms of anatomy, especially vascularization and innervation. MTLs , (MTLs) findings structure MEDLINEPubMed MEDLINE PubMed MEDLINE/PubMed Scholar restrictions MetaAnalyses Meta Analyses PRISMA (PRISMA statement dissections andor or investigations selected 198 last 2020 9 patients one examination plateau However innervation (MTLs 19 202 1 20 2

RESUMO O ajuste dos modelos de volume pelo método tradicional (dados obtidos por meio de cubagem de várias árvores) é a maneira mais utilizada para obter equações de volume. Este método demanda muito esforço e é bastante oneroso, portanto algumas alternativas têm sido desenvolvidas para diminuir a amostragem do número de árvores e obter resultados de estimativas semelhantes ao obtido pelo método tradicional, destacando-se a modelagem mista aplicada para calibrar equações. Neste trabalho, o objetivo da pesquisa foi calibrar o modelo de volume de Schumacher-Hall por meio da predição de efeitos aleatórios em nível de povoamento e compará-lo com as equações obtidas pela abordagem tradicional. A base de dados é composta de 670 árvores com idades variando de 1 a 10,75 anos. As calibrações testadas no modelo misto foram: i) a maior árvore da variável d para cada povoamento; ii) as duas maiores árvores da variável d para cada povoamento; iii) as três maiores árvores em d para cada povoamento; iv) as quatro maiores árvores em d para cada povoamento; v) as cinco maiores árvores em d para cada povoamento; vi) a árvore mediana para a variável d em cada povoamento; vii) uma árvore aleatória em cada povoamento; viii) três árvores, sendo a menor árvore, a árvore média e a maior da variável d para cada povoamento; ix) três árvores, sendo a árvore média, a árvore média menos dois desvios padrões e a árvore média mais dois desvios padrões para a variável d em cada povoamento. As estatísticas para avaliação das equações foram o coeficiente de determinação, o erro padrão da estimativa, a análise de resíduos e a análise gráfica dos valores observados e estimados. Os resultados evidenciam que as equações de volume podem ser calibradas em nível de povoamento por meio da amostragem de três árvores sendo elas, a árvore média, a árvore média mais dois desvios padrões e a árvore média menos dois desvios padrões, considerando que no método tradicional são cubadas 50 árvores em média no inventário florestal, a redução da amostragem em um novo povoamento seria de 94%. oneroso destacandose destacando se trabalho SchumacherHall Schumacher Hall comparálo compará lo 67 1075 10 75 10,7 anos i ii iii iv v vi vii viii ix determinação estimativa estimados elas 5 florestal 94 94% 6 107 7 10, 9

ABSTRACT The fitting of volume models by the traditional method (data obtained by means of scaling several trees), is the most used way to obtain volume equations. This method requires a lot of effort and is quite costly, therefore some alternatives have been developed to decrease the sampling of the number of trees and obtain results of estimates similar to that obtained by the traditional method, highlighting the mixed modeling applied to calibrate equations. In this work, the general objective of the research was to calibrate the Schumacher-Hall volume model by predicting random effects at the stand level and comparing it with the equations obtained using the traditional approach. The database is made up of 670 trees with ages varying from 1 to 10.75 years. The calibrations tested in the mixed model were using: (i) the largest tree of variable d for each stand; (ii) the two largest trees of variable d for each stand; (iii) the three largest trees in d for each stand; (iv) the four largest trees in d for each stand; (v) the five largest trees in d for each stand; (vi) the median tree for variable d in each stand; vii) one random tree in each stand; viii) three trees, being the smallest tree, the mean tree and the largest tree for the variable d for each stand; ix) three trees, being the mean tree, the mean tree minus two standard deviations and the mean tree plus two standard deviations for the variable d in each stand. The statistics for evaluating the equations were the coefficient of determination, the standard error of the estimate, the analysis of residuals, and the graphical analysis of the observed and estimated values. The results show that the volume equations can be calibrated at the stand level by sampling three trees: the average tree, the average tree plus two standard deviations, and the average tree minus two standard deviations. Considering that in the traditional method, 50 trees on average are measured in the forest inventory, the reduction of sampling in a new stand would be 94%. data , trees) costly work SchumacherHall Schumacher Hall approach 67 1075 10 75 10.7 years i (i ii (ii iii (iii iv (iv v (v vi (vi vii viii ix determination estimate residuals values 5 inventory 94 94% 6 107 7 10. 9

RESUMO O desenvolvimento do sistema nervoso humano compõe uma série de eventos fundamentais e interdependentes envolvendo o nascimento, crescimento e maturação neuronal, além da seleção positiva ou negativa de sinapses desses neurônios que participarão da composição de circuitos neurais essenciais à atividade do sistema nervoso. Nesse contexto, em que o ambiente e as relações sociais parecem ser marcadores relevantes para o neurodesenvolvimento, técnicas avançadas de neuroimagem e ferramentas de avaliação comportamental têm demonstrado alterações em regiões cerebrais e funções cognitivas em crianças que se desenvolvem em ambientes de baixo ou alto nível socioeconômico. Considerando os aspectos mencionados, esta revisão teve como objetivo identificar a importância do status socioeconômico no desenvolvimento cerebral infantil, buscando identificar quais são os impactos desses fatores na formação morfológica e fisiológica do sistema nervoso, permitindo maior compreensão da importância dos fatores ambientais nos processos de neurodesenvolvimento. nascimento neuronal contexto neurodesenvolvimento mencionados infantil

ABSTRACT The development of the human nervous system makes up a series of fundamental and interdependent events involving birth, growth, and neuronal maturation, in addition to the positive or negative selection of synapses of these neurons that will participate in the composition of neural circuits essential to the activity of the nervous system. In this context, where environment and social relationships seem to be relevant markers for neurodevelopment, advanced neuroimaging techniques and behavioral assessment tools have demonstrated alterations in brain regions and cognitive functions among children developing in low or high socioeconomic status environments. Considering the aspects mentioned, this review aimed to identify the importance of socioeconomic status in children’s brain development, seeking to identify what are the impacts of these factors on the morphological and physiological formation of the nervous system, allowing a greater understanding of the importance of environmental factors in neurodevelopmental processes. birth growth maturation context neurodevelopment environments mentioned childrens s processes

Resumen El objetivo del estudio fue investigar los efectos de la implementación de cuotas raciales en la representación de los negros en el sector legal, a partir del racismo estructural como práctica esclavista de discriminación racial. Se adoptó una metodología cualitativa, con entrevistas semiestructuradas y análisis documental de avisos públicos y resultados de concursos públicos que prevén cuotas raciales para carreras de derecho en el estado de Río de Janeiro en los últimos diez años. Se seleccionaron once titulares de cargos directivos en carreras jurídicas ‒fiscal, juez, procurador fiscal y defensor‒ autodeclarados negros. Con base en la percepción de los entrevistados, se realizó un análisis de la aplicación de la política de cuotas en las licitaciones públicas de las carreras de derecho. Los resultados indican evidencias de fallas en la implementación de esta política, tanto con base en disposiciones legales y análisis de documentos, como en la percepción de los encuestados. Se concluye que la simple previsión de reserva de vacantes no fue suficiente para aumentar la diversidad racial burocrática y que el racismo estructural es uno de los impedimentos para el éxito de la política de cuotas. legal cualitativa años ‒fiscal juez defensor entrevistados documentos encuestados

Resumo O objetivo do estudo foi investigar os efeitos da implementação das cotas raciais na representatividade de negros no setor jurídico, tendo por base o racismo estrutural como prática escravocrata de discriminação racial. Para tanto, adotou-se uma abordagem qualitativa, com a realização de entrevistas semiestruturadas e análise documental dos editais e resultados dos concursos públicos com previsão de cotas raciais para as carreiras jurídicas do estado do Rio de Janeiro nos últimos dez anos. Foram selecionados 11 ocupantes de posições de liderança nas carreiras jurídicas - promotor, juiz, procurador e defensor - autodeclarados negros. Baseando-se na percepção dos entrevistados, realizou-se uma análise da aplicação da política de cotas nos concursos públicos para as carreiras jurídicas. Os resultados apontam evidências de falhas na implementação dessa política, tanto com base nos dispositivos legais e na análise documental, quanto na percepção dos respondentes. Conclui-se que a simples previsão de reserva de vagas não foi suficiente para aumentar a diversidade racial burocrática e que o racismo estrutural é um dos impedimentos para o sucesso da política de cotas. jurídico adotouse adotou se qualitativa anos 1 promotor juiz Baseandose Baseando entrevistados realizouse realizou respondentes Concluise Conclui

Abstract This study investigates the effects of the implementation of racial quotas on the representation of black people in the legal sector, based on structural racism as a slave-holding practice of racial discrimination. A qualitative methodology was adopted, with semi-structured interviews and documental analysis of public notices and results of public tenders, with a prediction of racial quotas for legal careers in the state of Rio de Janeiro in the last ten years. Eleven holders of leadership positions in legal careers were selected - prosecutor, judge, attorney, and defender - self-declared black. Based on the interviewees’ perception’, an analysis was made of applying the quota policy in public tenders for legal careers. The results point to evidence of failures in the implementation of this policy, both based on legal provisions and document analysis, and on the respondents’ perceptions. It is concluded that the simple prediction of vacancies was not enough to increase bureaucratic racial diversity and structural racism is one of the impediments to the success of the quota policy. sector slaveholding slave holding discrimination adopted semistructured semi structured years prosecutor judge attorney selfdeclared self declared interviewees perception, perception , perception’ respondents perceptions

ABSTRACT Objective: To evaluate the association between obesity and hospitalization in mild COVID-19 adult outpatients in Brazil. Subjects and methods: Adults with signs and symptoms suggestive of acute SARS-CoV-2 infection who sought treatment in two hospital (public and private) emergency departments were prospectively enrolled. Patients with confirmed COVID-19 at inclusion were followed by phone calls at days D7, D14 and D28. Multivariable logistic regression models were employed to explore the association between obesity and other potential predictors for hospitalization. Results: A total of 1,050 participants were screened, and 297 completed the 28-day follow-up and were diagnosed with COVID-19 by RT-PCR. The median age was 37.2 (IQR 29.7-44.6) years, and 179 (60.0%) were female. The duration of symptoms was 3.0 (IQR 2.0-5.0) days, and 10.0 (IQR 8.0-12.0) was the median number of symptoms at inclusion. Ninety-five (32.0%) individuals had obesity, and 233 (78.5%) had no previous medical conditions. Twenty-three participants (7.7%) required hospitalization during the follow-up period. After adjusting, obesity (BMI ≥ 30.0 kg/m2) (OR = 2.69, 95% CI 1.63-4.83, P < 0.001) and older age (OR = 1.05, 95% CI 1.01-1.09, P < 0.001) were significantly associated with higher risks of hospitalization. Conclusion: Obesity, followed by aging, was the main factor associated with hospital admission for COVID-19 in a young population in a low-middle income country. Our findings highlighted the need to promote additional protection for individuals with obesity, such as vaccination, and to encourage lifestyle changes.

Resumo: O objetivo deste artigo é discutir como ocorre a mediação do literário no curso de Letras de uma universidade do sul do Brasil da rede da Associação Catarinense das Fundações Educacionais (Acafe) e o impacto dessa mediação na formação do(a) futuro(a) docente. É uma pesquisa qualitativa de natureza exploratória. O instrumento de coleta utilizado consistiu em entrevista por meio de grupo focal com oito acadêmicos do curso de Letras, na disciplina de Estudos Literários. A professora de Literatura não foi entrevistada, mas é considerada sujeito de pesquisa porque, mediante os depoimentos dos acadêmicos, identificamos as percepções sobre a atuação dela em sala de aula, suas escolhas metodológicas e teóricas. A análise dos dados ocorreu de acordo com a análise de conteúdo segundo Franco (2008). O estudo fundamentou-se em Barthes (2015, 1992), Duarte Júnior (2010, 2012), Mirian Martins (2005, 2014), Neitzel et al. (2017), Todorov (2020), entre outros. Os resultados indicam que: a mediação da leitura do literário ocorreu a partir da concepção da professora de que mediar implica uma postura de valorização do outro; a mediação deu-se por meio de objetos e espaços propositores - livros, pinturas, músicas, cartões-postais, trechos de filmes, entre outros -, os quais a professora explorou para oportunizar aos(às) acadêmicos(as) a apreciação do texto literário como objeto estético e artístico; os espaços propositores, como corredores, escadas, bibliotecas, espaços ao ar livre e a própria sala de aula, foram experimentados para ampliar as percepções dos(as) acadêmicos(as) sobre a obra e por ela serem afetados(as). As experiências reverberaram e há indícios de que contribuíram para a educação estética dos(as) futuros(as) docentes.

Abstract: This paper aims to discuss how literary mediation occurs in a Language and Literature course at a university in the Southern of Brazil, which is part of Santa Catarina’s Association of Educational Foundations (Acafe) and its impact on the education of future teachers. This is an exploratory qualitative research. Data was collected through an interview with an eight-student focus group taking the Literary Studies subject. Though not an interviewee, the literature teacher was considered a research participant because, through the academics' testimonies, student’s perceptions were identified about her performance in the classroom, and her methodological and theoretical choices. The data analysis followed the content analysis based on Franco (2008). The study was drawn from Barthes (2015, 1992), Duarte Júnior (2010, 2012), Martins (2005, 2014), Neitzel et al. (2017), Todorov (2020), among others. Results indicate: the mediation of the literary reading occurred from the professor’s conception that to mediate implies an attitude of valuing the other; mediation took place by the proposition of objects and spaces - books, paintings, music, postcards, excerpts from films, among others -, which the professor explored to give the students the opportunity to appreciate the literary text as an aesthetic and artistic object; the proposition spaces, such as corridors, stairs, libraries, outdoor spaces and the classroom, were experimented to broaden the students’ perceptions of the book and to be affected by it. The experiences rippled and there are indications that they contributed to the aesthetic education of the future teachers.

Resumen: El objetivo de este artículo es discutir cómo ocurre la mediación de lo literario en la carrera de Letras de una Universidad del sur de Brasil de la red 'Associação Catarinense das Fundações Educacionais (Acafe)' y su impacto en la formación del(la) futuro(a) docente. Es una investigación cualitativa de naturaleza exploratoria. El instrumento de recolección de datos consistió en una entrevista a través de un Focus Group de 8 (ocho) estudiantes del grado de Letras, en la asignatura de Estudios Literarios. La profesora de literatura no fue entrevistada, pero se la considera sujeto de investigación porque, a través de los testimonios de los estudiantes universitarios, identificamos sus percepciones sobre su desempeño en el aula, sus elecciones metodológicas y teóricas. El análisis de los datos fue de acuerdo con el contenido, según Franco (2008). El estudio se fundamentó en Barthes (2015, 1992), Duarte Júnior (2010, 2012) Martins (2005, 2014), Neitzel et al. (2017), Todorov (2020), entre otros. Los resultados indican: la mediación de la lectura de lo literario ocurrió a partir de la concepción de la profesora de que mediar implica una postura de valoración del otro; la mediación se dio por medio de objetos y espacios propulsores - libros, pinturas, música, tarjetas postales, extractos de películas, y otros-, que la docente exploró con el fin de posibilitar a los(as) estudiantes universitarios(as) la apreciación del texto literario como objeto estético y artístico; los espacios propulsores, como pasillos, escaleras, bibliotecas, espacios al aire libre y el proprio aula en sí, fueron experimentados a fin de ampliar las percepciones de los estudiantes del grado sobre la obra y analizar como ella les afectó. Las experiencias repercutieron y hay indicios de que contribuyeron a la educación estética de los(las) futuros(as) docentes.

Abstract Objective: to evaluate the accuracy of an antibody point-of-care lateral flow immunoassay (LFI -Wondfo Biotech Co., Guangzhou, China) in a pediatric population. Methods: children and adolescents (2 months to 18 years) with signs and symptoms suggestive of acute SARS-CoV-2 infection were prospectively investigated with nasopharyngeal RT-PCR and LFI at the emergency room. RT-PCR was performed at baseline, and LFI at the same time or scheduled for those with less than 7 days of the clinical picture. Overall accuracy, sensitivity and specificity were assessed, as well as according to the onset of symptoms (7-13 or ≥14 days) at the time of the LFI test. Results: In 175 children included, RT-PCR and LFI were positive in 51 (29.14%) and 36 (20.57%), respectively. The overall sensitivity, specificity, positive and negative predictive value was 70.6% (95%CI 56.2-82.5), 96.8% (95%CI 91.9-99.1), 90.0% (95%CI 77.2-96.0), and 88.9% (95%CI 83.9-92.5), respectively. At 7-13 and ≥14 days after the onset of symptoms, sensitivity was 60.0% (95%CI 26.2-87.8) and 73.2% (95%CI 57.1-85.8) and specificity was 97.9% (95%CI 88.7-99.9) and 96.1% (95%CI 89.0-99.2), respectively. Conclusion: Despite its high specificity, in the present study the sensitivity of LFI in children was lower (around 70%) than most reports in adults. Although a positive result is informative, a negative LFI test cannot rule out COVID-19 in children.