Resumo O carreamento nasal de Staphylococcus aureus representa um risco considerável para infecções tanto nosocomiais quanto comunitárias. O objetivo do trabalho foi investigar a prevalência de carreamento nasal de S. aureus sensíveis (SAMS) e resistentes à meticilina (SARM) em profissionais da saúde; determinar sua associação com fatores epidemiológicos e seus padrões de resistência aos antimicrobianos. Foram coletadas 152 amostras nasais de funcionários de dois hospitais da cidade de Bahía Blanca (Argentina). Os isolados de S. aureus foram identificados por métodos convencionais e pelo sistema automatizado BD PhoenixTM 100. A prevalência de carreamento nasal de S. aureus foi de 32,2% e a de SARM, de 12,2%. A frequência de carreamento no pessoal do laboratório foi estatisticamente significativa (58,8%). Os isolados foram sensíveis a trimetoprim-sulfametoxazol, cloranfenicol, rifampicina, fluoroquinolonas e vancomicina. Esses dados alertam para a necessidade de identificar portadores de S. aureus e implementar estratégias que controlem a propagação potencial desses microrganismos.

Abstract The nasal carriage of Staphylococcus aureus represents a considerable risk for both nosocomial and community infections. The objective of this work was to investigate the prevalence of nasal carriage of both methicilin-susceptible (MSSA) and methicillin-resistant S. aureus (MRSA) in health workers, to determine their association with epidemiological factors and their patterns of antimicrobial resistance. One hundred and fifty-two nasal samples were taken from personnel from two hospitals in the Bahía Blanca city (Argentina). The S. aureus isolates were identified by conventional methods and by the automated BD PhoenixTM 100 system. The prevalence of S. aureus nasal carriage was 32.2% and that of MRSA, 12.2%. The frequency of carrying deterin laboratory personnel was statistically significant (58.8%). The isolates were susceptible to trimethoprim-sulfamethoxazole, chloramphenicol, rifampin, fluoroquinolones and vancomycin. These data warn of the need to identify S. aureus carriers and implement strategies that control the potential spread of these microorganisms.

Resumen La portación nasal de Staphylococcus aureus representa un riesgo considerable para infecciones tanto nosocomiales como comunitarias. El objetivo del trabajo fue investigar la prevalencia de portación nasal de S. aureus sensibles (SAMS) y resistentes a meticilina (SAMR) en trabajadores de la salud, determinar su asociación con factores epidemiológicos y sus patrones de resistencia a los antimicrobianos. Se tomaron 152 muestras nasales de personal de dos hospitales de la ciudad de Bahía Blanca (Argentina). Los aislados de S. aureus se identificaron por métodos convencionales y por el sistema automatizado BD PhoenixTM 100. La prevalencia de portación nasal de S. aureus fue de 32,2% y, de SAMR, de 12,2%. La frecuencia de portación en el personal de laboratorio (58,8%) resultó estadísticamente significativa. Los aislados fueron sensibles a trimetoprima-sulfametoxazol, cloranfenicol, rifampicina, fluoroquinolonas y vancomicina. Estos datos alertan sobre la necesidad de identificar portadores de S. aureus e implementar estrategias que controlen una potencial diseminación de estos microorganismos.

ABSTRACT A recent trend in Aristotelian scholarship tries to link ethics and biology. Within these attempts, some sort of continuity between the character of non-rational animals and that of human beings has been proposed, so that the starting point ofmoral development could be identified in Aristotle’s description of animal’s character. In this article I argue that this reading should strongly qualified, for understood in some ways it entails a sort of continuity between natural normativity and practical normativity that belongs to an Archimedean ethical naturalism, which cannot be reconstructed from Aristotle’s writings. Connected to this, I argue that the concept of natural virtue is not a natural concept, but an ethical one that only makes sense from within the realm of practical normativity; natural virtue, thus understood, is not part of a genetic (or bottom-up) explanation of virtue, but emerges from a conceptual whole-part analysis. In this manner, natural virtue is no prior, but posterior to ethical virtue.

RESUMEN Recientes intentos por conectar la ética y la biología aristotélicas marcan una suerte de continuidad entre el carácter de los animales no racionales y de los seres humanos, de modo tal que en la descripción de los caracteres de los animales no racionales puede identificarse el punto de partida biológico del propio ser humano en el desarrollo de su carácter moral. En este artículo, propongo señalar los límites de este tipo de lectura, ya que, entendida de cierto modo, ella implica una continuidad entre la normatividad natural y la normatividadpráctica propia de un naturalismo fundacionalista que no puede atribuirse a Aristóteles. En conexión con ello, sostengo que el concepto de virtud natural no es un concepto natural, sino ético, tal que sólo cobra sentido en el marco de la normatividad práctica; la virtud natural, en este sentido, no forma parte de una explicación genética de la virtud sino de un análisis que va del todo a las partes, de acuerdo al cual ella no es anterior sino posterior a la virtud ética.

Resumen: En Metafísica E 2 y 3 Aristóteles discute el problema de lo que es por accidente y sus causas, con el fin último de examinar si esto puede ser objeto de la filosofía primera. El resultado de esta discusión es, en este sentido, negativo. Sin embargo, la filosofía primera tiene algo que decir acerca del accidente, aunque solo sea mediante un discurso de segundo orden. La naturaleza de lo accidental es así explorada en estas páginas de la Metafísica para confirmar la imposibilidad de un estudio científico acerca de esta forma de ser y sus causas. La parte central de este artículo discute el complejo pasaje E 2, 1026b27-1027a15, donde Aristóteles presenta las causas de lo que es por accidente. Procuraré mostrar que las tres causas allí presentadas son no solo compatibles, sino también relevantes para la completa caracterización de lo accidental, en la medida en que pueden entenderse como la causa formal, eficiente y material de lo que es por accidente.

Abstract: Aristotle’s Metaphysics E 2 and 3 are devoted to the discussion about accidental being and its causes, with the aim of assessing its credentials as a possible object of first philosophy. The result of this discussion is, in this sense, negative. However, first philosophy has something to say about accidental being, if only through a second order speech. The nature of the accidental is thus explored in these pages of Metaphysics, with the ultimate aim of confirming the impossibility of a scientific study (and a scientific discourse) about this way of being and its causes. The central part of this paper deals with E 2, 1026b27-1027a15, where Aristotle introduces the causes of accidental being. I endeavor to show that each of the three causes presented in these lines are compatible and relevant, as they can be understood, respectively, as the formal, efficient and material cause of what happens by accident.

Chlamydia trachomatis genital infection is nowadays considered one of the most frequent causes of sexually transmitted infections (STI) in the world, mainly affecting the group of young people under 25 years old. The aim of this study was to determine the prevalence of C. trachomatis infection in newly admitted students to Universidad Nacional del Sur, Bahía Blanca, Argentina, and to evaluate the risk factors to acquire STI. For that purpose, 204 young college students with a mean age of 19 were involved in this study. Each participant delivered a sample of first-void urine and completed a questionnaire which was then submitted anonymously. The research for C. trachomatis was done on 114 valid samples through a technique of DNA amplification, whose molecular target was the gene ompA. Four cases of infection by C. trachomatis were detected with a prevalence of 3.5 %. The risks factors associated to the infection were a history of 7 or more partners since the start of sexual activity and contact with a new sexual partner in the last 4 months. The prevalence of such infection reflects a moderate circulation of this microorganism in the studied population. This fact, along with some aspects shown by the questionnaire results, would characterize a population having a low risk profile for acquiring STIs. However, some other information obtained from the questionnaires gave some opposite evidence, which would alert us on the need of keeping watch, raising awareness and implementing preventive actions in this population.

La infección genital por Chlamydia trachomatis es considerada en la actualidad una de las causas más frecuentes de infecciones transmisibles sexualmente (ITS) a nivel mundial y afecta principalmente al grupo de jóvenes menores de 25 años. El objetivo de este estudio fue determinar la prevalencia de la infección por C. trachomatis en alumnos ingresantes a la Universidad Nacional del Sur (Bahía Blanca, Argentina) y evaluar los factores de riesgo para la adquisición de ITS. Participaron en el estudio 204 jóvenes de edad media de 19 años, que remitieron una muestra de orina de primera micción y respondieron a una encuesta anónima. La investigación de C. trachomatis se realizó sobre 114 muestras válidas mediante una técnica de amplificación génica, cuyo blanco molecular es el gen ompA. Se detectaron 4 casos de infección por C. trachomatis, lo que implicó una prevalencia del 3,5 %. Los factores de riesgo que demostraron estar asociados con la adquisición de esta ITS fueron un historial de 7 o más parejas desde el comienzo de las relaciones sexuales y el contacto con una nueva pareja sexual en los últimos 4 meses. La prevalencia de infección por C. trachomatis reflejó una moderada circulación de este microorganismo en la población estudiada. Si bien algunos aspectos revelados en las encuestas sugieren una población de bajo riesgo para la adquisición de ITS en general, otros datos evidencian lo contrario y alertan sobre la necesidad de incrementar la vigilancia y desarrollar acciones de concienciación y prevención en esta población.

The purpose of this study is to compare scanning electron microscopy findings of the blister roof in three distinct bullous diseases: one intraepidermal acantholytic (pemphigus foliaceus); one due to hemidesmosomal dysfunction (bullous pemphigoid); and one secondary to anchoring fibril dysfunction - type VII collagen (dystrophic epidermolysis bullosa). In pemphigus foliaceus, acantholytic phenomena were readily demonstrated. In bullous pemphigoid, the epidermis had a solid aspect. In dystrophic epidermolysis bullosa a net was seen in the blister roof.

The association of microphthalmia and linear skin defects was named microphthalmia with linear skin defects syndrome (MLS) or MIDAS syndrome (microphthalmia, dermal aplasia, and sclerocornea), an X-chromosomal disorder manifesting mainly in females. We examined a female newborn with facial linear skin defects following the Blaschko lines. Computer tomography and ophthalmological examination confirmed bilateral microphthalmia. An interstitial microdeletion at Xp22.2, encompassing the entire HCCS gene, was identified. Dermatoscopic examination showed erythematous linear areas with telangectasias and absence of sebaceous glands, which appear as brilliant white dots. Vellus hairs were also absent in the red areas. Dermatoscopy could help to establish the diagnosis of MLS/MIDAS syndrome by confirming the aplastic nature of the lesions.

Sucrose use in wound treatment is a common practice that seems to promote tissue healing and reduce microbial load. The objective here was thus to analyze the scientific evidence through an integrative review to determinate indications and contraindications for use of sucrose in the form of granulated, brown (unrefined muscovado sugar) and/or refined sugar in infected wounds and thus assist the professional in clinical decision-making. Ten studies published in full articles were selected, from the period 2002 to 2012 and indexed in the PubMed, Cinahl, Lilacs and Cochrane databases. Considering the analysis of studies, mostly experimental in the animal model, sugar's effectiveness in tissue repair was verified, as was positive modulation in the inflammatory response. To elucidate the mechanisms or action of sucrose in the wound, further clinical trials are recommended in order to standardize the concentration, volume and frequency of sucrose in changes of wound dressings.

El uso de sacarosa en el tratamiento de heridas es una práctica común que promueve la cicatrización de tejidos y reduce la carga microbiana. El objetivo fue analizar las evidencias científicas mediante la revisión integradora para determinar la indicación y contraindicación del uso de sacarosa (azúcar cristal, marrón y/o refinado) en heridas infectadas y ayudar al profesional en la toma de decisiones clínicas. Seleccionaron 10 estudios publicados, de 2002 a 2012, indexados en PubMed, Cinahl, Lilacs y Cochrane. Teniendo en cuenta el análisis de los estudios, principalmente en modelos animales experimentales, se verificó la eficacia de azúcar en la reparación tisular y modelaje positiva de las respuestas inflamatorias. Con el fin de dilucidar los mecanismos de acción de sacarosa en la herida, se recomiendan ensayos clínicos adicionales para normalizar la concentración, el volumen y la frecuencia de sacarosa en el cambio de las coberturas.

O uso de sacarose na terapêutica de feridas é uma prática comum que parece favorecer a cicatrização tissular e reduzir a carga microbiana. Objetivou-se, desta forma analisar as evidências científicas por meio da revisão integrativa a fim de determinar a indicação e contraindicação do uso da sacarose (nas apresentações de açúcar cristal, mascavo e/ou refinado) em feridas infectadas e assim auxiliar o profissional na tomada de decisão clínica. Selecionaram-se 10 estudos publicados na íntegra, no período de 2002 a 2012 e indexados no PubMed, Cinahl, Lilacs e Cochrane. Considerando a análise dos estudos, em sua maioria experimentais no modelo animal, verificou-se a efetividade do açúcar na reparação tecidual e modulagem positiva na resposta inflamatória. Com vistas a elucidar os mecanismos ou ação da sacarose na ferida, recomendam-se ensaios clínicos adicionais para padronizar a concentração, volume e periodicidade da sacarose nas trocas de coberturas.

Realizamos microscopia eletrônica de varredura do teto invertido de uma bolha de um caso de pênfigo foliáceo. Com pequeno aumento, a perda da adesão intercelular pôde ser vista claramente. Os queratinócitos acantolíticos demostraram um contorno irregular, algumas vezes poligonal. Células arredondadas, como vistas tipicamente na microscopia óptica, também foram observadas. O exame de um teto de bolha permite uma documentação ultraestrutural das alterações acantolíticas.

We performed scanning electron microscopy of an inverted blister roof in a case of pemphigus foliaceus. The loss of intercellular adherence could be easily seen with low magnification. The acantholytic keratinocytes displayed an irregular and sometimes polygonal contour. Round cells, typically seen in light microscopy, were also observed. The examination of a blister roof allows ultrastructural documentation of the acantholytic changes.

OBJETIVO: O objetivo desse estudo foi verificar a associação do nível sérico do magnésio com o uso de inibidores de bomba de prótons (IBP) e outros fatores. MÉTODOS: Realizou-se estudo transversal com 151 pacientes admitidos com doenças agudas no serviço de medicina interna do Hospital de Clínicas de Porto Alegre. Foram excluídos aqueles pacientes com condições usualmente relacionadas à hipomagnesemia: diarréia; vômitos; diabéticos agudamente descompensados; uso crônico de laxantes, álcool, diuréticos ou outros fármacos relacionados. RESULTADOS: Todos os pacientes apresentaram níveis normais de magnésio. Albumina e creatinina sérica se associaram positivamente com os níveis de magnésio sérico, após ajuste para fatores confundidores. Não houve diferença no nível sérico de magnésio em usuários ou não-usuários de IBP ou entre homens e mulheres. Não houve correlação com idade, nível sérico de fósforo e potássio. As principais limitações desse estudo foram a ausência de instrumento para medir a adesão aos IBPs e o tamanho da amostra. CONCLUSÃO: A associação do uso de IBP e hipomagnesemia é rara. Defeitos congênitos no metabolismo do magnésio devem ser responsáveis pelo surgimento de hipomagnesemia em usuários de dessa classe de fármacos.

OBJECTIVE: The aim of this study was to evaluate the association of serum magnesium levels with proton pump inhibitors (PPIs) use and other factors. METHODS: This was a cross-sectional study of 151 patients admitted with acute diseases in the Internal Medicine Division of the Hospital de Clinicas de Porto Alegre, after the exclusion of conditions that are commonly associated with hypomagnesemia: diarrhea; vomiting; chronic alcohol use; severely uncompensated diabetes mellitus; and chronic use of laxatives, diuretics or other drugs causing magnesium deficiency. RESULTS: All patients had normal serum magnesium levels. Serum albumin and creatinine levels were positively associated with serum magnesium levels, after adjusting for confounders. There was no difference between mean serum magnesium levels of PPI users and non-users, nor between men and women; there was also no correlation among age, serum phosphorus, and potassium levels with serum magnesium levels. Limitations of this study include the absence of an instrument for measuring adherence to PPI use and the sample size. CONCLUSION: The association of PPI use and hypomagnesemia is uncommon. Congenital defects in the metabolism of magnesium may be responsible for hypomagnesemia in some patients using this drug class.

En el artículo se examinan los dos intentos de Aristóteles por explicar el fenómeno de las acciones voluntarias e involuntarias: Ética Eudemia (EE) II 6-9 y Ética Nicomaquea (EN) III 1. Entre ambos tratamientos hay muchas coincidencias, pero también diferencias sustantivas, tanto en la caracterización de las acciones involuntarias como en la estrategia argumentativa general y la definición de lo voluntario. El artículo procura dar cuenta de dichas diferencias de contenido en función de la estrategia metodológica general por la que opta Aristóteles en uno y otro caso.

The article examines Aristotle's two attempts to explain the phenomena of voluntary and involuntary actions: Eudemian Ethics (EE) II 6-9 and Nicomachean Ethics (EN) III 1. Though there are notorious coincidences, there are also substantial differences between them in the characterization of involuntary actions, in the general argumentative strategy, and in the definition of voluntary actions. The paper endeavors to account for these material differences on the basis of the general methodological strategy used by Aristotle in each case.

This paper deals with the Aristotelian treatment of two fallacies or deceitful arguments: Composition and Division. First I examine the way in which Aristotle presents these arguments in the Sophistic Refutations (SE), and secondly, I study the presentation of Rhetoric (Rh.), II, 24. This analysis makes clear that in each writing, "Composition" and "Division" are actually referred to arguments with a completely different structure. To this extent, Composition and Division are presented as a particularly clear example of the fact that the treatment of fallacies in Rh. II, 24 is not a mere repetition of what had been studied in SE, but implies a strong innovation, partly dependent on the particular subject matter of rhetorical argumentation.

El presente trabajo se ocupa del tratamiento aristotélico de dos argumentos aparentes o falacias: la Composición y la División. En primer lugar, se analiza el modo en que Aristóteles presenta estos argumentos en las Refutaciones Sofísticas (SE) y, en segundo lugar, se estudia la presentación de Retórica (Rh.) II, 24. Esto permite ver que lo que en uno y otro escrito se llama Composición y División está referido, en realidad, a argumentos aparentes con una estructura totalmente diferente. Así, el caso de la Composición y la División muestra de manera ejemplar hasta qué punto el tratamiento de las falacias en Rh., II, 24 no es una mera repetición de lo estudiado en SE, sino que implica una fuerte innovación que responde, en parte, a las características del objeto de la argumentación retórica.

The text of Physics 2.8 has been recently interpreted so as to restore the reading that Aristotle holds an external, and even an anthropocentric, natural teleology. This reading has been defended by D. Furley, and especially by D. sedley. In this paper I present several arguments against this interpretation of the text. Thus, I will argue that Aristotle does not claim, in this chapter, that it rains for the sake of the growing of the crop, against an opinion which is currently somewhat extended among interpreters.

El texto de Física II 8 ha constituido recientemente ocasión para rehabilitar la tesis según la cual Aristóteles sostendría la vigencia de una teleología natural externa, e incluso antropocéntrica, sobre todo a partir del trabajo de D. Furley y especialmente de D. Sedley. En este trabajo ofrezco una serie de argumentos en contra de esta interpretación del texto de la Física. De este modo, defenderé la lectura según la cual Aristóteles no sostiene, en este capítulo, que llueve con vistas al crecimiento del grano, en contra de lo que hoy constituye una opinión un tanto extendida.