Abstract Emerging evidence has revealed a cross-talk in the etiopathogenesis of burning mouth syndrome (BMS) related to peripheral nerve fibers (NF) and neuropeptides secreted by mast cells. Here, we investigated the S-100+ density and PGP 9.5+ integrity of peripheral NF and the tryptase+ mast cell density in the oral mucosa of BMS patients and healthy individuals. A total of 23 oral mucosa specimens (12 BMS and 11 controls) were evaluated. The clinical diagnosis of BMS was based on a careful examination, excluding other local and systemic causes. Samples were taken from an incisional biopsy of the tongue mucosa of individuals with symptomatic BMS, while the margins of the non-neoplastic tongue biopsy served as controls of healthy individuals. Immunohistochemistry was performed to determine the density/mm2 of S-100+, PGP 9.5+ peripheral NF, and tryptase+ mast cells. Similar densities of S-100+, PGP 9.5+ peripheral NF, and tryptase+ mast cells were found in cases of BMS, with a median value of 3.70, 0.70, and 29.24/mm2, respectively, and in the control group, with a median value of 2.60, 0.80, and 26.01/mm2, respectively (p > 0.05). Moreover, the relationship between S100+ and PGP 9.5+ peripheral NF was the same in both groups (p = 0.70). This study demonstrated that there were no alterations in the density and integrity of peripheral NF in the tongue of symptomatic BMS patients. However, the sensitization of peripheral NF in this disease may not depend on mast cell density. crosstalk cross talk (BMS (NF Here S100 S 100+ 100 S-100 95 9 5 9.5 tryptase 2 12 (1 1 evaluated examination causes nonneoplastic non neoplastic densitymm2 densitymm mm2 mm density/mm S100+, 100+, 370 3 70 3.70 070 0 0.70 2924mm2 29 24 29.24/mm2 group 260 60 2.60 080 80 0.80 2601mm2 26 01 26.01/mm2 p 0.05. 005 0.05 . 05 0.05) Moreover 0.70. 0.70) However S10 10 S-10 9. ( 37 7 3.7 07 0.7 2924mm 29.24/mm 6 2.6 08 8 0.8 2601mm 26.01/mm 00 0.0 S1 S-1 3. 0. 2. S-

OBJETIVO: Avaliar a atividade cicatrizante do laser diodo Alumínio Gálio Índio Fósforo (AlGaInP), ë660nm em feridas cutâneas induzida em ratos. MÉTODOS: Foram utilizados 54 ratos Wistar, fêmeas, divididos em três grupos (n=18) e subdivididos em três subgrupos (n=6) animais para serem estudados no 5, 10 e 15º dias após o procedimento cirúrgico. A ferida foi induzida em região dorso-cervical utilizando punch. As lesões foram irradiadas em dias alternados com laser AlGaInP, nas densidades de energia de 3J/cm² (L3) ou 6J/cm²(L6). O grupo controle não recebeu irradiação. No 5,10 e 15º dia após o procedimento cirúrgico os animais foram eutanasiados e a área de reparo foi removida e os cortes histológicos foram corados com hematoxilina-eosina e picrossírius. Foram avaliados aspectos macroscópicos e histológicos das lesões nos tempos citados, bem como análises morfométricas da angiogênese e do conteúdo de colágeno. RESULTADOS: A atividade cicatrizante do laser AlGaInP foi evidenciada pelo aumento da angiogênese do grupo L3 e L6 em relação ao grupo controle (GC) no 5º dia (p=0,0001) e diminuição do infiltrado de polimorfonucleares e hemorragia (p=0,045 e p=0,007 respectivamente) dos grupos L3 e L6 em relação ao controle. No 10 e 15ºdias observou-se também que nos grupos tratados com laser L3 e L6 houve estimulo acentuado a fibroplasia(p=0,0003 e p=0,034 respectivamente), quando comparados ao grupo controle (GC). CONCLUSÃO: O laser AlGaInP atuou de forma positiva sobre a cicatrização de feridas cutâneas em ratos.

PURPOSE: To evaluate the effect the healing activity of diode laser Indium Gallium Aluminum Phosphorus (InGaAlP) ë660nm on healing of surgical wounds in rats. METHODS: Fifty-four female Wistar rats were used, divided into three groups (n=18) and subdivided into three subgroups (n=6) to be studied in 5, 10 and 15th days after surgical procedures. The wound was induced in the dorsal-cervical using punch. The lesions were irradiated on alternate days with InGaAlP laser, the energy densities of 3J/cm² (L3) or 6J/cm² (L6). The control group received no irradiation. At 5, 10 and 15th days after surgery the animals were euthanized and the repair area was removed and histological sections were stained with hematoxylin-eosin and picrossírius. We evaluated macroscopic and histological lesions in the times cited, as well as morphometric analysis of angiogenesis and collagen content. RESULTS: The wound healing activity InGaAlP laser was evidenced by increased angiogenesis group L3 and L6 in relation to control group (CG) at the 5th day (p=0.0001) and decreased polymorphonuclear infiltrate and hemorrhage (p=0.045 and p=0.07 respectively) in the groups L3 and L6 in relation to control group (GC). On the 10 and 15th days was also observed in groups treated with laser L3 and L6 stimulation was pronounced fibroplasia (p=0.0003 and p=0.034 respectively) when compared with the control group (CG). CONCLUSION: The InGaAlP laser acted positively on the healing of skin wounds in rats.

PROPOSTA: Cistos epidermóide e dermóide são cistos de desenvolvimento extremamente raros, de natureza benigna, que podem ocorrer em qualquer região do corpo e somente 7% são encontrados na região de cabeça e pescoço. Este artigo apresenta o caso clínico de uma paciente que possuía um cisto epidermóide juntamente com as características das imagens por ressonância magnética. DESCRIÇÃO DO CASO: Paciente do gênero feminino, 36 anos, apresentou-se com queixa de dificuldade de fonação e deglutição. O exame clínico intrabucal revelou uma extensa tumefação em soalho bucal. As imagens por ressonância magnética indicaram uma lesão de natureza cística, homogênea, de conteúdo sólido e localizada abaixo do músculo milohiódeo. A lesão foi enucleada e encaminhada para exame anatomopatológico, cujo diagnóstico foi compatível com cisto epidermóide. CONCLUSÃO: A imagem por ressonância magnética foi essencial para determinar as características da lesão de acordo com a sua localização anatômica.

PURPOSE: Epidermoid and dermoid cysts are extremely rare developmental cysts of a benign nature, which may occur anywhere in the body, although about 7% are found in the head and neck. This article reports a clinical case of a patient who had an epidermoid cyst and its magnetic resonance imaging (MRI) features. CASE REPORT: This case discusses an epidermoid cyst in a 36-year-old woman complaining about speech difficulty. Clinical examination revealed an extensive swelling on the floor of the mouth. MRI findings showed a cystic homogenous lesion located underneath the mylohyoid muscle which was removed by surgery. Histological examination of the mass confirmed the diagnosis of an epidermoid cyst. CONCLUSION: We concluded that MRI was considered useful for a more accurate diagnosis prior to treatment.

O diagnóstico por imagens tem passado por grandes transformações nos últimos dez anos, determinadas especialmente pela revolução tecnológica no campo da informática e da descoberta de novas fontes de energia para obtenção de imagens do interior do corpo humano. As imagens seccionais ou tomográficas, como a tomografia computadorizada (TC) e imagens por ressonância magnética (RM), reúnem muitos princípios e qualidades da modalidade ideal, o que inclui a obtenção de imagens eficientes, precisas em relação aos aspectos anatômicos, com riqueza de detalhes tridimensionais. O objetivo desta revisão, ilustrada por casos clínicos, é fornecer ao profissional uma noção geral da importância e das principais aplicações dessas técnicas tomográficas no contexto da Ortodontia.

Imaging diagnosis has gone through many transformations in the last ten years. Revolutionary technology advances in computer science and energy sources being newly applied in the field of medicine are the main reasons for these transformations. The sectional imaging techniques, such as computed tomography (CT) and magnetic resonance imaging (MRI) have most of the principles and qualities of the ideal imaging modality. This includes the determination of anatomic truth in terms of accurate portrayal of spatial orientation, size, form and relationships of desired structures or features, which require assessment of three-dimensional details. The aim of this review, illustrate by clinical cases, is to provide an overview of the importance of CT and MRI in the orthodontic field.