ABSTRACT Introduction: Improving survival of Acute Lymphoblastic Leukemia (ALL) in adult patients has been a challenge. Despite intensive chemotherapy treatment, overall survival is poor. However, several studies demonstrate that young adult patients have better survival when treated with pediatric-based intensive regimens. Considering these results, We decided to treat newly diagnosed ALL patients according to age and risk factors. The goal of this study was to describe the results of this intensive chemotherapy treatment approach for ALL adult patients diagnosed at our institution. Methods: Fifty-eight ALL patients, diagnosed from 2004 to 2013, were included in the analysis. Patients were assigned to either the St. Jude Total Therapy XIIIB high-risk arm (St Jude) or the CALGB 8811 (CALGB). The Kaplan-Meier survival curve was used for the survival analyses and the Cox proportional hazard regression, for multivariable analysis. Results: The overall survival was 22.9% at 10 years. The St. Jude improved survival, compared to the CALGB (p = 0.007), with 32.6% vs. 7.4% survival rate at 10 years. However, no survival benefit was found for patients younger than 20 years old (p = 0.32). The multivariable analysis demonstrated that undetectable minimal residual disease (MRD) and hematopoietic stem cell transplantation (HSCT) had beneficial impact on survival (p = 0.0007 and p = 0.004, respectively). Conclusion: ALL is a disease of poor prognosis for adults. The joint effort to standardize treatment and seek solutions is the way to start improving this scenario. Introduction (ALL challenge However pediatricbased pediatric based regimens factors institution Methods Fiftyeight Fifty eight 200 2013 St highrisk high 881 CALGB. . (CALGB) KaplanMeier Kaplan Meier regression Results 229 22 9 22.9 1 0.007, 0007 0.007 , 0 007 0.007) 326 32 6 32.6 vs 74 7 4 7.4 2 0.32. 032 0.32 0.32) MRD (MRD HSCT (HSCT 00007 0.000 0004 004 0.004 respectively. respectively respectively) Conclusion adults scenario 201 88 (CALGB 22. 000 0.00 00 3 32. 7. 03 0.3 0000 8 0.0 0.