With the growth of data traffic, demand of huge number of digital devices and their interconnection to establish a reliable communication, the internet has become a potential demand of the society. To develop a system that securely connects the internet to real-world space would aid in the advancement of a human-centered society that balances economic progress with the resolution of social issues. This paper provides a detailed aspect of Society 5.0 with its requirements, architecture, and components. We have proceeded extensively with the state-of-the-art Society 5.0 and its link with Industry 4.0/5.0. Furthermore, the role of Society 5.0 in the sustainable development goals of the United Nations is well elaborated. Several emerging communication and computing technologies such 5G/5G-Internet of Things (IoT), edge computing/ cloud computing/ fog computing, Internet of everything, blockchain, and beyond networks have been also well explored to fulfill the demands of Society 5.0. The potential application of super smart cities (Society 5.0) with some real-time experience of inhabitants is thoroughly discussed. Finally, we highlighted several open research challenges with opportunities. OPEN LICENSE: CC BY-NC-ND

Abstract Supraglottic airway devices (SAD) have got popularity in the anesthetic practice owing to easy insertion, rapid airway access and lower incidence of complications. Igel® is a second generation SAD with a non‐inflatable cuff and gastric drainage channel. Despite ease of insertion, there are still cases of failure of Igel® insertion to secure airway. We are hereby presenting a case of unanticipated difficulty in Igel® insertion in a 35-years-old female due to a hypopharyngeal growth. This article aims to send a reminder that despite anticipated easy airway, definitive plan for securing airway should always be ready.

Melatonin referred as the hormone of darkness is mainly secreted by pineal gland, its levels being elevated during night and low during the day. The effects of melatonin on insulin secretion are mediated through the melatonin receptors (MT1 and MT2). It decreases insulin secretion by inhibiting cAMP and cGMP pathways but activates the phospholipaseC/IP3 pathway, which mobilizes Ca2+from organelles and, consequently increases insulin secretion. Both in vivo and in vitro, insulin secretion by the pancreatic islets in a circadian manner, is due to the melatonin action on the melatonin receptors inducing a phase shift in the cells. Melatonin may be involved in the genesis of diabetes as a reduction in melatonin levels and a functional interrelationship between melatonin and insulin was observed in diabetic patients. Evidences from experimental studies proved that melatonin induces production of insulin growth factor and promotes insulin receptor tyrosine phosphorylation. The disturbance of internal circadian system induces glucose intolerance and insulin resistance, which could be restored by melatonin supplementation. Therefore, the presence of melatonin receptors on human pancreatic islets may have an impact on pharmacotherapy of type 2 diabetes.