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Efficacy of sunscreen with photolyase or regular sunscreen associated with topical antioxidants in treating advanced photodamage and cutaneous field cancerization: a randomized clinical trial
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Alvares, Bruno Augusto

; Miola, Anna Carolina

; Schimitt, Juliano Vilaverde

; Miot, Helio Amante

; Abbade, Luciana Patricia Fernandes

Anais Brasileiros de Dermatologia

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apr 2022, Volume 97 N. 2 Pages 157 - 165

Abstract: En | Text: En | PDF: En

Abstract Background Several treatments are available for skin with advanced photodamage, which is characterized by the presence of actinic keratoses (AK). Objectives Evaluate the efficacy of using sunscreen with photolyase compared to regular sunscreen, as well as to compare the combination of a topical formulation of antioxidants versus placebo in the treatment of advanced photodamage. Methods This was a randomized, double-blind, factorial clinical trial. Participants with AKs on their forearms were randomized to apply regular sunscreen (SC) or sunscreen with photolyase (SC+P) on both forearms during the day. One of the forearms in each group was randomized again to receive topical antioxidants (AOx), and the other forearm received a placebo cream (both for night application). The four groups were SC/AOx, SC/placebo, SC+P/AOx, and SC+P/placebo. The duration of treatment was 8 weeks. Primary outcomes were total AK clearance, decrease in Forearm Photoaging Scale (FPS), and AK severity scores. Secondary outcomes were reduction in AK count, partial clearance rate, and safety. Results Forty participants (80 forearms) were included. All groups showed significant improvement in outcomes at week eight. There were no significant differences between SC and SC+P for either outcome. AOx led to a significant reduction in AK count (22%; p < 0.05). Partial clearance was obtained in 18 (47.4%) forearms treated with AOx and in 9 (23.7%) treated with placebo (p < 0.05). All groups reduced the FPS score, without significant differences among them. Conclusions There is no difference in the treatment of advanced photodamage skin when comparing the use of sunscreen with photolyase and regular sunscreen, and topical antioxidants were more efficient in reducing AK count than placebo. Study limitations Short interval of follow-up and absence of re-evaluation in the absence of treatment were limitations of the present study.

https://doi.org/10.1016/j.abd.2021.06.005

Tumoral melanosis without metastasis: a report after three years of follow-up,
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Miola, Anna Carolina

; Esposito, Ana Claudia Cavalcante

; Stolf, Hamilton Ometto

; Miot, Helio Amante

Anais Brasileiros de Dermatologia

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dec 2021, Volume 96 N. 6 Pages 797 - 798

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.abd.2020.04.016

Considerations on the development of surgical techniques for the treatment of onychocryptosis
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Miola, Anna Carolina

; Alcantara, Giovana Piteri

; Miot, Luciane Donida Bartoli

; Miot, Helio Amante

Anais Brasileiros de Dermatologia

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oct 2021, Volume 96 N. 5 Pages 651 - 652

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.abd.2021.06.002 18 downloads

Profile of the use of dermoscopy among dermatologists in Brazil (2018),
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Barcaui, Carlos Baptista

; Miot, Helio Amante

Anais Brasileiros de Dermatologia

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oct 2020, Volume 95 N. 5 Pages 602 - 608

Abstract: En | Text: En | PDF: En

Abstract Background: Dermoscopy increases the diagnostic accuracy in dermatology. The aspects related to training, usage profile, or perceptions of usefulness of dermoscopy among dermatologists in Brazil have not been described. Objectives: To evaluate the profile of the use of dermoscopy and the perception of the impact of the technique on clinical practice. Methods: The Brazilian Society of Dermatology invited all members to complete an online form with 20 items regarding demographic data, dermatological assistance, use of dermoscopy, and perceptions of the impact of the technique on clinical practice. The proportions between the categories were compared by analysis of residuals in contingency tables, and p-values < 0.01 were considered significant. Results: The answers from 815 associates (9.1% of those invited to participate) were assessed, 84% of whom were female, and 71% of whom were younger than 50 years of age. The use of dermoscopy was reported in the daily practice of 98% of dermatologists: 88% reported using it more than once a day. Polarized light dermoscopy was the most used method (83%) and pattern analysis was the most used algorithm (63%). The diagnosis and follow-up of melanocytic lesions was identified as the main use of the technique, while the benefit for the diagnosis of inflammatory lesions was acknowledged by less than half of the sample (42%). Study limitations: This was a non-randomized study. Conclusion: Dermoscopy is incorporated into the clinical practice of almost all Brazilian dermatologists, and it is recognized for increasing diagnostic certainty in different contexts, especially for pigmented lesions.

https://doi.org/10.1016/j.abd.2020.04.007 294 downloads

Leproma's dermoscopy,
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Miola, Anna Carolina

; Bicudo, Natalia Parenti

; Tsutsui, Giuliane Minami

; Miot, Helio Amante

Anais Brasileiros de Dermatologia

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jun 2020, Volume 95 N. 3 Pages 383 - 385

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.abd.2019.09.027 306 downloads

Contribution to characterization of skin field cancerization activity: morphometric, chromatin texture, proliferation, and apoptosis aspects,
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Miola, Anna Carolina

; Castilho, Mariana Anteghini

; Schmitt, Juliano Vilaverde

; Marques, Mariangela Esther Alencar

; Miot, Helio Amante

Anais Brasileiros de Dermatologia

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nov 2019, Volume 94 N. 6 Pages 698 - 703

Abstract: En | Text: En | PDF: En

Abstract Background: A skin field cancerization is a cutaneous area with subclinical changes resultant from chronic sun exposure, with a higher predisposition to development of pre-neoplastic and neoplastic lesions. So far, there are no well-defined objective parameters that can indicate their degree of activity. Objectives: To describe and compare morphometric aspects and expression of factors related to apoptosis and cell proliferation in actinic keratosis (AK), in both photoexposed and photoprotected epidermis. Methods: A cross-sectional study of patients with actinic keratosis in the forearms, biopsied at two points: the actinic keratosis and the axillary region. The biopsies of the actinic keratosis, perilesional area, and axilla were evaluated through keratinocyte intraepithelial neoplasia (KIN), and immunohistochemistry of p53, survivin, and Ki67. Nuclear morphometry of basal layer cells was performed through digital image analysis: entropy, area, perimeter, Ra, fractal dimension, circularity, color intensity, and largest diameter. Results: There were 13 patients included and 38 actinic keratosis biopsied. In morphometry, 1039 nuclei were analyzed, of which 228 represented axillary skin, 396 demonstrated actinic keratosis, and 415 represented the perilesional area to the actinic keratosis. There was a significant difference (p < 0.05) in all variables tested for the topographies evaluated. A significant correlation was identified between nucellar morphometric elements, KIN, proliferation markers, and apoptosis. Joint patterns of p53, Ki67, and KIN discriminated the topographies sampled. Study limitations: This was a cross-sectional study with a small number of patients. Conclusions: There are patterns of proliferation, resistance to apoptosis, and different cellular morphometrics between photoprotected skin and photoexposed skin. The joint expression of p53, Ki67, and KIN can characterize skin field cancerization activity.

https://doi.org/10.1016/j.abd.2019.03.003 275 downloads

Exuberant tufted folliculitis
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Ramos, Paulo Müller

; Miot, Helio Amante

Anais Brasileiros de Dermatologia

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feb 2019, Volume 94 N. 1 Pages 115 - 116

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/abd1806-4841.20197952 3284 downloads

Successful management of chronic refractory onycholysis by partial nail avulsion followed by topical tretinoin
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Dias, Pedro Colli Rocha

; Miola, Anna Carolina

; Miot, Helio Amante

Anais Brasileiros de Dermatologia

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feb 2019, Volume 94 N. 1 Pages 118 - 119

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/abd1806-4841.20198009 2524 downloads

Evaluation Instruments for Quality of Life Related to Melasma: An Integrative Review
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Pollo, Camila Fernandes

; Meneguin, Silmara

; Miot, Helio Amante

Clinics

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2018, Volume 73 elocation e65

Abstract: En | Text: En | PDF: En

The aim of this study was to analyze scientific production concerning the validation and cultural adaptation of quality of life evaluation instruments for patients with melasma and to offer a critical reflection on these methods. A literature review was performed based on a search of the Web of Science, Bireme, PubMed, Elsevier Scopus, and Google Scholar databases. All published articles from indexed periodicals in these electronic databases up to December 2015 were included. Eight articles were identified, of which only one (12.5%) referred to the development and validation of a specific instrument for evaluation of the quality of life of melasma patients. An additional six articles (75%) referred to transcultural adjustment and validation of the same instrument in other languages, and another (12.5%) article reported the development of a generic instrument for evaluation of quality of life in patients with pigment disorders. This review revealed only one specific instrument developed and validated in different cultures. Despite being widely used, this instrument did not follow the classic construction steps for psychometric instruments, which paves the way for future studies to develop novel instruments.

https://doi.org/10.6061/clinics/2018/e65 2159 downloads

10.

Quality of life in men diagnosed with anogenital warts
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Camargo, Caio Cavassan de

; D'Elia, Maria Paula Barbieri

; Miot, Helio Amante

Anais Brasileiros de Dermatologia

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jun 2017, Volume 92 N. 3 Pages 427 - 429

Abstract: En | Text: En | PDF: En

Abstract Anogenital warts are a worldwide public health problem. They consist of epithelial proliferations caused by HPV, whose transmission occurs mainly through sexual intercourse. In this study, we evaluated their impact on the quality of life of adult males. We interviewed 88 men in an outpatient clinic for sexually transmitted diseases at a Brazilian public institution, using the DLQI-BRA questionnaire. Most patients (81%) presented mild or no impairment of quality of life. The main dimensions affected were sex life, symptoms, and embarrassment. The low impact on quality of life may well justify the delay in seeking medical treatment, favoring the spread of the disease.

https://doi.org/10.1590/abd1806-4841.20175282 1097 downloads

11.

Diabetes mellitus and the skin
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Mendes, Adriana Lucia

; Miot, Helio Amante

; Haddad Junior, Vidal

Anais Brasileiros de Dermatologia

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feb 2017, Volume 92 N. 1 Pages 8 - 20

Abstract: En | Text: En | PDF: En

Abstract: Several dermatoses are routinely associated with diabetes mellitus, especially in patients with chronic disease. This relationship can be easily proven in some skin disorders, but it is not so clear in others. Dermatoses such necrobiosis lipoidica, granuloma annulare, acanthosis nigricans and others are discussed in this text, with an emphasis on proven link with the diabetes or not, disease identification and treatment strategy used to control those dermatoses and diabetes.

https://doi.org/10.1590/abd1806-4841.20175514 11622 downloads

12.

Quality of life and religious-spiritual coping in palliative cancer care patients
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Matos, Ticiane Dionizio de Sousa

; Meneguin, Silmara

; Ferreira, Maria de Lourdes da Silva

; Miot, Helio Amante

Revista Latino-Americana de Enfermagem

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2017, Volume 25 elocation e2910

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivos: comparar a qualidade de vida e o coping religioso-espiritual de pacientes em cuidados paliativos oncológicos com um grupo de participantes sadios; avaliar se a percepção de qualidade de vida está associada às estratégias de coping religioso-espiritual; identificar as variáveis clínicas e sociodemográficas relacionadas à qualidade de vida e ao coping religioso-espiritual. Método: estudo transversal, realizado com 96 pacientes de ambulatório de cuidados paliativos, em um hospital público no interior do Estado de São Paulo, e 96 voluntários saudáveis, por meio de questionário utilizando dados sociodemográficos, o McGill Quality of Life Questionnaire e o Coping Religioso-Espiritual-Breve. Resultados: foram entrevistados 192 participantes que apresentaram boa qualidade de vida e alta utilização do Coping Religioso-Espiritual. Houve maior uso de Coping Religioso-Espiritual negativo no Grupo A, assim como menor bem-estar físico, psicológico e de qualidade de vida. Observou-se associação entre escores de qualidade de vida e Coping Religioso-Espiritual (p<0,01) em ambos os grupos. Sexo masculino, religião católica e escore de Coping Regioso-Espiritual-Breve influenciaram, de forma independente, os escores de qualidade de vida (p<0,01). Conclusão: ambos os grupos apresentaram escores altos de qualidade de vida e de Coping Espiritual-Religioso. Participantes do sexo masculino, praticantes de religião católica e com maiores escores de Coping Espiritual-Religioso apresentaram melhor percepção de qualidade de vida, sugerindo que essa estratégia de enfrentamento possa ser estimulada em pacientes sob cuidados paliativos.

ABSTRACT Objectives: to compare the quality of life and religious-spiritual coping of palliative cancer care patients with a group of healthy participants; assess whether the perceived quality of life is associated with the religious-spiritual coping strategies; identify the clinical and sociodemographic variables related to quality of life and religious-spiritual coping. Method: cross-sectional study involving 96 palliative outpatient care patient at a public hospital in the interior of the state of São Paulo and 96 healthy volunteers, using a sociodemographic questionnaire, the McGill Quality of Life Questionnaire and the Brief Religious-Spiritual Coping scale. Results: 192 participants were interviewed who presented good quality of life and high use of Religious-Spiritual Coping. Greater use of negative Religious-Spiritual Coping was found in Group A, as well as lesser physical and psychological wellbeing and quality of life. An association was observed between quality of life scores and Religious-Spiritual Coping (p<0.01) in both groups. Male sex, Catholic religion and the Brief Religious-Spiritual Coping score independently influenced the quality of life scores (p<0.01). Conclusion: both groups presented high quality of life and Religious-Spiritual Coping scores. Male participants who were active Catholics with higher Religious-Spiritual Coping scores presented a better perceived quality of life, suggesting that this coping strategy can be stimulated in palliative care patients.

RESUMEN Objetivos: comparar la calidad de vida y el coping religioso-espiritual de pacientes en cuidados paliativos oncológicos con un grupo de participantes sanos; evaluar si la calidad de vida percibida está asociada a las estrategias de coping religioso-espiritual; identificar las variables clínicas y sociodemográficas relacionadas a la calidad de vida y al coping religioso-espiritual. Método: estudio transversal, desarrollado con 96 pacientes de ambulatorio de cuidados paliativos en un hospital público en el interior del Estado de São Paulo, Brasil, y 96 voluntarios sanos, mediante cuestionario utilizando datos sociodemográficos, el McGill Quality of Life Questionnaire y el Coping Religioso-Espiritual-Breve. Resultados: fueron entrevistados 192 participantes que presentaron buena calidad de vida y alta utilización del Coping Religioso-Espiritual. Fue encontrado mayor uso de Coping Religioso-Espiritual negativo en el Grupo A, y también menor bienestar físico, psicológico y de calidad de vida. Fue observada asociación entre los scores de calidad de vida y Coping Religioso-Espiritual (p<0,01) en ambos grupos. Sexo masculino, religión católica y score de Coping Religioso-Espiritual-Breve influenciaron de manera independiente los scores de calidad de vida (p<0,01). Conclusión: ambos grupos presentaron altas puntuaciones de calidad de vida y de Coping Espiritual-Religioso. Participantes do sexo masculino, practicantes de religión católica y con mayores scores de Coping Espiritual-Religioso presentaron mejor percepción de calidad de vida, sugiriendo la posibilidad de estimular esa estrategia de enfrentamiento en pacientes bajo cuidados paliativos.

https://doi.org/10.1590/1518-8345.1857.2910 8029 downloads

13.

Quality of life and religious-spiritual coping in palliative cancer care patients
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Matos, Ticiane Dionizio de Sousa

; Meneguin, Silmara

; Ferreira, Maria de Lourdes da Silva

; Miot, Helio Amante

Revista Latino-Americana de Enfermagem

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2017, Volume 25 elocation e2910

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

https://doi.org/10.1590/1518-8345.1857.2910 241 downloads

14.

Brazilian Consensus on Photoprotection
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Schalka, Sérgio

; Steiner, Denise

; Ravelli, Flávia Naranjo

; Steiner, Tatiana

; Terena, Aripuanã Cobério

; Marçon, Carolina Reato

; Ayres, Eloisa Leis

; Addor, Flávia Alvim Sant'anna

; Miot, Helio Amante

; Ponzio, Humberto

; Duarte, Ida

; Neffá, Jane

; Cunha, José Antônio Jabur da

; Boza, Juliana Catucci

; Samorano, Luciana de Paula

; Corrêa, Marcelo de Paula

; Maia, Marcus

; Nasser, Nilton

; Leite, Olga Maria Rodrigues Ribeiro

; Lopes, Otávio Sergio

; Oliveira, Pedro Dantas

; Meyer, Renata Leal Bregunci

; Cestari, Tânia

; Reis, Vitor Manoel Silva dos

; Rego, Vitória Regina Pedreira de Almeida

Anais Brasileiros de Dermatologia

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dec 2014, Volume 89 N. 6 Pages 1 - 74

Abstract: En | Text: En | PDF: En

Brazil is a country of continental dimensions with a large heterogeneity of climates and massive mixing of the population. Almost the entire national territory is located between the Equator and the Tropic of Capricorn, and the Earth axial tilt to the south certainly makes Brazil one of the countries of the world with greater extent of land in proximity to the sun. The Brazilian coastline, where most of its population lives, is more than 8,500 km long. Due to geographic characteristics and cultural trends, Brazilians are among the peoples with the highest annual exposure to the sun. Epidemiological data show a continuing increase in the incidence of non-melanoma and melanoma skin cancers. Photoprotection can be understood as a set of measures aimed at reducing sun exposure and at preventing the development of acute and chronic actinic damage. Due to the peculiarities of Brazilian territory and culture, it would not be advisable to replicate the concepts of photoprotection from other developed countries, places with completely different climates and populations. Thus the Brazilian Society of Dermatology has developed the Brazilian Consensus on Photoprotection, the first official document on photoprotection developed in Brazil for Brazilians, with recommendations on matters involving photoprotection.

https://doi.org/10.1590/abd1806-4841.20143971 14207 downloads

15.

Syndrome In Question
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Nascimento, Ana Claudia Mendes do

; Gaspardo, Daniela Barros Cortez

; Cortez, Tatiana Mimura

; Miot, Helio Amante

Anais Brasileiros de Dermatologia

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jan 2014, Volume 89 N. 1 Pages 177 - 179

Abstract: En | Text: En | PDF: En

The authors present a male 40-year-old patient with established diagnosis of Behçet's disease which had evolved to recurrent bilateral auricular polychondritis crises. MAGIC syndrome (mouth and genital ulcers with inflamed cartilage) is rare and groups together patients with this clinical picture without necessarily fulfilling the clinical criteria for Behçet's disease or relapsing polychondritis, demonstrating an independent disorder.

https://doi.org/10.1590/abd1806-4841.20142615 2298 downloads

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