RESUMO O objetivo deste trabalho foi investigar os principais aspectos que determinaram a utilização da remuneração baseada em ações e as variáveis que influenciam o montante pago. Este artigo preenche a lacuna relacionada à celeuma anterior quanto às variáveis que impactam na decisão de remunerar baseado em ações, como também esclarece os fatores que impactam sua magnitude, além de um tratamento estatístico mais robusto em relação à endogenia. O Brasil é conhecidamente um país onde predomina o conflito de agência entre acionista controlador e minoritários, assim, é relevante entender os determinantes da adoção e do montante pago aos gestores utilizando opções de ações, pois a remuneração pode ser utilizada como forma de tunneling. Este estudo identificou um possível trade-off entre remuneração em dinheiro e ações, tendo em vista o aumento de endividamento da empresa. Também verificou que, no mercado brasileiro, esse tipo de remuneração não está relacionado com governança e desempenho. Utilizou-se a regressão com dados em painel com efeitos fixos na firma e no Setor*Ano para eliminar o possível viés advindo de heterogeneidades constantes no tempo para as firmas e choques nas indústrias, em particular ano. Ademais, para identificar os determinantes, utilizou-se a regressão logística com dados em painel e efeito fixo no Setor*Ano. A amostra do estudo compreendeu 287 empresas abertas na Bolsa, Brasil, Balcão (B3). Esta pesquisa expõe que 40% das empresas no período de 2010 a 2016 utilizaram remuneração baseada em ações, entretanto, o montante pago ainda é baixo, 0,03% do ativo total das empresas. Os resultados indicam que, no mercado brasileiro, variáveis como oportunidades de investimento e tamanho da empresa aumentam a probabilidade da adoção do employee stock options plans (ESOP). Ademais, referente ao montante pago, este é negativamente relacionado com o endividamento da empresa, indicando que, numa possível diminuição de liquidez, a empresa opta por remunerar o gestor com ações para diminuir sua exposição a riscos sistêmicos.

ABSTRACT This study’s aim was to investigate the main aspects that determined the use of the stock-based compensation model and the variables that influence the amount paid. The article fills the gap in the previous debate regarding the variables that affect the decision to offer stock-based remuneration, as well as revealing the factors that impact its magnitude and providing a more robust statistical treatment with regards to endogeny. Brazil is known to be a country where the agency conflict between controlling and minority shareholders predominates, and so it is important to understand the determinants of adoption and of the amount paid to managers using stock options, since remuneration can be used as a form of tunneling. This study identified a possible trade-off between cash and stock compensation, in view of increased company indebtedness. It also found that in the Brazilian market this type of remuneration is not related to governance and performance. A panel data regression was used with fixed effects in the firm and industry*year to eliminate the possible bias arising from constant heterogeneities in time for the firms and shocks in the industries in a particular year. In addition, to identify the determinants, we used a logistic regression with panel data and fixed effect in industry*year. The study sample comprised 287 companies listed on the Bolsa, Brasil, Balcão (B3) exchange. This research shows that 40% of the companies in the period from 2010 to 2016 adopted stock-based compensation plans; however, the amount paid is still low, at 0.03% of total company assets. The results indicate that in the Brazilian market variables such as investment opportunities and company size increase the likelihood of adopting the employee stock options plan (ESOP). In addition, regarding the amount paid, this is negatively related to company leverage, indicating that in possible liquidity shocks the companies opt to compensate managers with shares to reduce their exposure to systematic risks.

Abstract Objective: To investigate the socioeconomic, demographic and health needs that influence the access to oral health actions. Material and Methods: The sample consisted of 609 individuals who lived in areas covered by the Family Health Strategy in a city of the Northeast of Brazil. All individuals living in areas covered by the FHS with age equal to or higher than six years were included. Data analysis included descriptive, bivariate and multivariate statistics using decision-tree based Chi-squared automatic interaction detection (CHAID). Results: Most participants were female, aged 25-34 years, ranging in age from 6 to 87 years. It was evidenced that, among the studied variables, the most relevant for understanding the access to oral health actions were: age (p<0.001), educational level (p-value in Node 1 = 0.009; p-value in Node 7 = 0.005) and self-perception of oral health (p=0.001). Conclusion: The results suggest that access to oral health actions is influenced by several social and individual factors, and it is marked by inequalities that favor individuals with higher educational level, better self-perception of oral health and lower age groups.

The aim of this work was to prepare hollow fiber membrane changing the composition of polyethersulfone, polyvinylpyrrolidone (PVP) and clay, through the phase inversion technique, evaluating the influence of these constituents on the viscosity and distinct morphologies. Flat membranes were produced and their contact angles were determined and showed difference when clay was added and/or PVP. For the hollow fiber membranes, the +addition of these constituents, PVP and/or clay in the solution, can change significantly the viscosity and effect the membrane formation. From the scanning electron microscopy (SEM) images, it was identified the influence on morphology with the compositional variation of each additive, with the PVP promoting shorter precipitation time, favoring the formation of pores of the “fingers” type and increasing the presence of macrovoids. The addition of clay favored the formation of spherical pores, reducing the presence of macropores.

Abstract Purpose: To evaluate the effect of tadalafil in renal ischemia/reperfusion (I/R) injury in rats Methods: Group I/R saline rats (n=6) were subjected to 45 minutes of left renal ischemia and treated with saline; the I/R tadalafil rats (n=6) received oral 10mg/kg tadalafil microemulsion one hour before ischemia. In both groups, 8 hours after ischemia, laboratory analysis were performed Results: Better tissue perfusion was lower in ischemic left/kidney than in right/kidney in saline group, suggesting reduced kidney clearance. Fluorescence in left/kidneys of tadalafil treated rats was lower than in right/kidneys (difference not significant). The fluorescence signal intensity in kidneys of tadafil treated rats was higher than in saline rats. TNF-α levels were significantly lower in I/R tadalafil group rats compared to I/R saline group (154±10.3 vs 391.3±12.3), as well as IL-1β (163.4±13.2 vs 279±11.5pg/dL), and IL-6 (122.9±8.1 vs 173.7±6.3 respectively; p=0.0001). Urea, creatinine and C-reactive protein were significantly lower in tadafil treated rats then in saline group Conclusion: Tadalafil therapy decreased the expression of circulating pro-inflammatory cytokines in a renal I/R rodent model, while improving kidney function proofs.

RESUMO Membranas podem ser consideradas películas poliméricas ou inorgânicas que funcionam como uma barreira semipermeável para uma filtração em escala molecular, separando duas fases e restringindo, total ou parcialmente, o transporte de uma ou várias espécies químicas (solutos) presentes na solução. Portanto, o objetivo deste trabalho é produzir membranas de poliétersulfona (PES) e poliétersulfona / argila pela técnica de inversão de fase e avaliar a presença de argila na obtenção de membranas para o tratamento de efluentes líquidos. O solvente utilizado foi a dimetilformamida (DMF) e argilas utilizadas foram Brasgel PA (MMT) e Cloisite Na (CL Na) nas proporções de 3 a 5% (em peso). Por difração de raios-X (DRX), as membranas com 3% das argilas MMT e CL Na aparentemente apresentaram estruturas parcialmente esfoliadas; para a composição com 5% de CL Na observou-se um pequeno pico, que indica que esta é, possivelmente, uma estrutura intercalada ou microcompósito. A partir dos resultados de microscopia eletrônica de varredura (MEV), visualizou-se que a superfície da membrana de PES puro apresentou uma estrutura aparentemente sem poros, no aumento utilizado e, uma superfície sem rugosidade quando comparada com às membranas com argila. As medidas de ângulo de contato indicaram que a inclusão da argila alterou a capacidade de molhamento das membranas. O fluxo com água destilada para todas as membranas iniciou alto e ao longo do tempo chegou a um patamar de estabilização. Assim, pôde-se concluir que a presença e o teor de argila alteraram a morfologia da membrana, contribuindo para um aumento do fluxo de água.

ABSTRACT Membranes can be considered polymeric or inorganic films that function as a semipermeable barrier to filtration on a molecular scale, separating two phases and restricting, totally or partially, the transportation of one or more chemical species (solute) present in the solution. Therefore, the aim of this work is to produce polyethersulfone membranes (PES) and polyethersulfone/clay by phase inversion technique and evaluate the presence of clay in obtaining membranes for wastewater treatment. The used solvent was dimethylformamide (DMF) and clays were Brasgel PA (MMT) and Cloisite Na (CL Na) in the proportion of 3 to 5% (wt.). By X-ray diffraction (XRD), the membranes with 3% of MMT and CL Na clays apparently had partially exfoliated structures. For the composition with 5% of CL Na a small peak was observed, which indicates that this is possibly an intercalated structure or microcomposite. By scanning electron microscopy (SEM), visualizes that the pure suface of the pure PES membrane a structure apparently without pores was observed in the used magnification and without roughness surface when compared to membranes with clay. The measurements of contact angle indicated that the inclusion of clay altered the wetting ability of the membranes. The flow with distilled water for all membranes started high and over time reached a stabilization level. Thus, it can be concluded that the presence and the content of clay altered the morphology of the membrane, contributing to an increase in water flow.

ABSTRACT PURPOSE: To evaluate the effects of modified coconut water as fluid of resuscitation combined with simvastatin in hemorrhagic shock and sepsis model in rats. METHODS: Four groups of Wistar rats with hemorrhagic shock and abdominal sepsis were studied (n=8/group). Rats were bled and maintained at a mean blood pressure 35mmHg for 60min. They were then resuscitated with: 1) saline 0.9%; 2) coconut water+3% NaCl; 3) coconut water+NaCl 3%+simvastatin microemulsion (10 mg/kg i.v.; 4) normal coconut water. At 8h post-resuscitation, blood and lungs were collected for exams. RESULTS: Clinical scores, TNF-α, IL-1β, liver/kidney proof levels, and lung injury were significantly reduced in coconut water+NaCl 3%+simvastatin group treated rats, comparing with the other resuscitation treatments. CONCLUSIONS: Resuscitation with coconut water with Nacl 3%+simvastatin had a significant beneficial effect on downregulating cytokines and decreasing lung injury in a rat model of abdominal sepsis and hemorrhagic shock. We also demonstrated that coconut water with Nacl 3%+simvastatin administration clearly made liver and kidney function better and improved clinical score.

ABSTRACT PURPOSE : To investigate the antimicrobial, immunological and healing effects of Melipona scutellaris honey on infected wounds of rat skin. METHODS: Twenty four Wistar rats were distributed in four groups (6-each). The uninfected skin wounds of group I rats were treated daily with saline for 7 days. Uninfected wounds (group II) rats were treated with honey. In group III (treated with saline) and group IV (treated with honey) wounds were inoculated with MRSA ATTC43300. The first bacterial culture was performed 24 hours later. In the 7th day new culture was done, and wound biopsies were used for cytokines dosage and histopathology. RESULTS: In group I and III rats the CFU/g count of S. aureus in wounds was zero. In group II rats the CFU/g counts in the wound tissue were significantly higher than in wounds of group IV rats. The density histopathological parameters and the expression of TNF-α, IL1-β, Il-6 were significantly higher on wounds of group IV then in the other groups. CONCLUSION: Honey of Melipona scutellaris was effective in the management of infected wounds, by significant bacterial growth inhibition, enhancement of cytokine expression, and positively influenced the wound repair.

Abstract Polymer/clay nanocomposites are a new class of composites with polymer matrices where the disperse phase is a silicate with elementary particles that have at least one of dimensions in nanometer order. Polyamide 6/Brazilian organoclay nanocomposites were prepared by melt intercalation, and the mechanical, thermal and thermomechanical properties were studied. The structure and morphology of the nanocomposites were evaluated by X-ray diffraction (XRD) and transmission electron microscopy (TEM). It was verified by XRD and TEM analysis that all systems presented exfoliated structure predominantly. By thermogravimetry (TG), nanocomposites showed higher stabilities in relation to pure polymer. It was observed that the nanocomposites showed better mechanical properties compared to the properties of polyamide 6. The heat deflection temperature (HDT) values of the nanocomposites showed a significant increase in relation to pure polymer.

PURPOSE:To evaluate the heart and the Tc-99m-sestamibi biodistribution after statin pretreatment in a rat model of abdominal sepsis.METHODS:Twenty-four Wistar rats were randomly distributed into four groups (n=6 per group): 1) sepsis with simvastatin treatment, 2) sepsis with vehicle, 3) sham control with simvastatin and 4) sham control with vehicle. 24 hours after cecal ligation and puncture rats received 1.0MBq of Tc-99m-sestamibi i.v. 30min after, animals were euthanized for ex-vivo tissue counting and myocardium histological analysis.RESULTS: Myocardial histologic alterations were not detected 24 hours post-sepsis. There was significantly increased cardiac Tc-99m-sestamibi activity in the sepsis group with simvastatin treatment (1.9±0.3%ID/g, p<0.001) in comparison to the sepsis group+vehicle (1.0±0.2%ID/g), control sham group+ simvastatin (1.2±0.3%ID/g) and control sham group (1.3±0.2%ID/g). Significant Tc-99m-sestamibi activity in liver, kidney and lungs was also detected in the sepsis group treated with simvastatinin comparison to the other groups.CONCLUSIONS:Statin treatment altered the biodistribution of Tc-99m-sestamibi with increased cardiac and solid organ activity in rats with abdominal sepsis, while no impact on controls. Increased myocardial tracer activity may be a result of a possible protection effect due to increased tissue perfusion mediated by statins.

The evolution in the knowledge of tuberculosis' physiopathology allowed not only a better understanding of the immunological factors involved in the disease process, but also the development of new laboratory tests, as well as the establishment of a histological classification that reflects the host's ability to contain the infectious agent. At the same time, the increasing bacilli resistance led to alterations in the basic tuberculosis treatment scheme in 2009. This article critically examines laboratory and histological investigations, treatment regimens for tuberculosis and possible adverse reactions to the most frequently used drugs.

Cutaneous tuberculosis (CTB) is the result of a chronic infection by Mycobacterium tuberculosis, M. ovis and occasionally by the Calmette-Guerin bacillus. The clinical manifestations are variable and depend on the interaction of several factors including the site of infection and the host's immunity. This article revises the current knowledge about this disease's physiopathology and immunology as well as detailing the possible clinical presentations.

Membranas de híbridos orgânico/inorgânico de poliamida 6 e argilomineral constituído de silicatos em camadas foram estudadas em comparação com o polímero puro. Uma argila sódica, como recebida da indústria, e outra organofilizada com os sais quaternários de amônio Dodigen e Cetremide foram utilizadas. Os sais tornam hidrofóbica a superfície da argila e favorecem sua incorporação na matriz polimérica no estado fundido. A partir dos nanocompósitos obtidos foram preparadas membranas por meio da técnica de imersão-precipitação, tendo como solvente o ácido fórmico e como método de produção a precipitação em um banho de água (não-solvente). O teor do ácido nas soluções poliméricas, dos híbridos e da poliamida 6 pura, foi variado para avaliar sua influência na morfologia e na permeabilidade das membranas produzidas. As membranas apresentaram morfologia assimétrica, constituída de uma pele filtrante e um suporte poroso. A presença da argila tratada com os diferentes sais alterou a formação dos poros, tanto na superfície como na seção transversal. As partículas de argila provavelmente atuaram como barreira ao fluxo. Observou-se ainda que o teor de ácido utilizado influenciou de forma significativa a estrutura assimétrica da membrana; quanto maior o teor de ácido maior a espessura da pele filtrante. O teor de ácido também levou à alteração do tamanho e da distribuição dos poros. As medidas de fluxo realizadas com os dois teores de ácido diferentes mostraram uma resposta em função da morfologia diferenciada obtida.

Organic/inorganic hybrid membranes of polyamide 6 and mineral clay containing layers of silicate were prepared and compared to those of the pure polymer. Use was made of an as-received sodium clay from industry and another organophilized with ammonium quaternary salts (Dodigen and Cetremide). The salts make the clays surface hydrophobic and improve their incorporation into the polymer matrix in the molten state. Membranes were prepared with these nanocomposites using the immersion-precipitation technique with formic acid as a solvent, and precipitation in a water bath as non-solvent. The acid concentration in the solution containing the polymer and the hybrids was varied to study its influence in morphology and permeability of the membranes. An asymmetric morphology consisting of a filter skin and a porous support was observed, with pores both on the surface and in the cross section being affected by the different salts. This asymmetric morphology was also affected significantly by the acid concentration, with thicker filter skins for higher concentrations. The acid concentration affected the pores size and their distribution. The clay particles probably acted as a barrier to the flow. The permeating flux for the two acid concentrations varied as a function of the distinct morphologies.

OBJETIVO: Caracterizar o vocabulário expressivo e analisar as variáveis regionais em uma amostra de escolares do primeiro ano do ensino fundamental de Maceió. MÉTODOS: Participaram 72 escolares de três escolas de Maceió. Para selecionar a amostra, os escolares foram submetidos às seguintes avaliações: avaliação da fala, por meio da prova de Fonologia do ABFW; avaliação do vocabulário expressivo, por meio da aplicação da Prova de Vocabulário do ABFW e avaliação do desenvolvimento infantil, por meio da Escala de Desenvolvimento Infantil Denver. Foram realizadas análises estatística descritiva e analítica (p<0,05). RESULTADOS: Não houve diferença de desempenho lexical entre os gêneros, nem entre as faixas etárias, mas foi verificada diferença entre as escolas. Os escolares apresentaram desempenho abaixo do esperado nos campos semânticos locais, vestuário, alimentos e formas e cores. Melhor desempenho foi observado para os campos semânticos animais, meios de transporte e móveis e utensílios. Os processos de substituição mais realizados foram: substituição por co-hipônimo, por valorização do estímulo visual, por vocábulos que designam seus atributos semânticos, por hiperônimos e parassinônimos. Foram observadas diferentes designações para os vocábulos balança, escorregador, privada e casinha. CONCLUSÃO: Os escolares de Maceió que compuseram a amostra apresentaram desempenho lexical semelhante, independente do gênero e da faixa etária, mas houve diferença para a variável escola.

PURPOSE: To characterize the expressive vocabulary and analyze the variables in a regional sample of students of first grade of elementary school in Maceió. METHODS: The sample was composed by 72 children from three Maceió public schools. To select the sample, the children underwent speech evaluation through the ABFW Test - Phonology; and expressive vocabulary through the ABFW - Vocabulary Test. Following, statistical analysis was conducted using Kruskal-Wallis, Mann-Whitney and Wilcoxon tests. Statistical significance was considered as p value smaller than 0.05. RESULTS: There was no difference between gender and among age ranges in lexical performance. Differences among schools were observed. When compared to data from the ABFW, the children from Maceió underachieved the expected scores in the semantic fields sites, clothing, food, and shapes and colors. The best performance was observed for the fields animal, vehicles, furniture and utensils. The most recurrent substitution processes were the co-hyponym, valorization of the visual stimulus, words that designate their semantic attributes, hypernym, parasynonym or equivalents. CONCLUSION: The children of Maceió present a similar lexical development, independent of gender or age group, with a difference only among the schools tested.

A apresentação clínica da paracoccidioidomicose é espectral. Podem ocorrer cura espontânea, estado de latência ou doença ativa após disseminação hematogênica com vários graus de gravidade. A morfologia e o número de lesões cutâneas irão depender da interação entre fatores próprios da imunidade do hospedeiro, que é específica e individual, e da virulência do fungo. Alguns indivíduos com boa imunidade natural somada a baixa virulência do fungo mantêm por tempo prolongado granulomas bem formados sem microorganismos e sorologia negativa, tornando o diagnóstico um desafio. Entretanto fatores inerentes ao fungo podem modular a resposta imune e modificar o quadro clínico ao longo do tempo. Os autores apresentam um caso sarcoidose símile e discutem os aspectos imunológicos envolvidos.

The clinical presentation of paracoccidioidomycosis is spectral. Spontaneous cure, state of latency or active disease with different levels of severity can occur after the hematogenous dissemination. The morphology and number of skin lesions will depend on the interaction of host immunity, which is specific and individual, and fungus virulence. Some individuals have natural good immunity, which added to the low virulence of the fungus maintain the presence of well-marked granulomas with no microorganism and negative serology for a long time, making the diagnosis a challenge. Factors inherent to the fungus, however, may modulate the immune response and modify the clinical picture over the time. We present a sarcoidosis-like clinical presentation and discuss the immunological factors involved.

Nanocomposites of polymer/clay have had much attention in recent years, particularly those developed with layered silicates due to the need of engineering materials more efficient than pure polymers for certain applications. The level of exfoliation of layered silicates in crystalline structure of polymer matrices has been studied and has been observed that it affects the crystalline behavior and the physical and mechanical properties. In this study, nanocomposites of polyamide 6 were obtained by the melt intercalation method, using a Brazilian bentonite modified with a quaternary ammonium salt. X-Ray Diffraction (XRD) results showed the incorporation of salt among the layers of clay, making it organophilic and that the nanocomposites presented exfoliated and/or partially exfoliated structures and confirmed by transmission electron microscopy (TEM). By thermogravimetry (TG), the results indicated that the presence of clay increased the thermal stability of polyamide 6. The impact properties of the nanocomposites showed inferior values in relation to the pure polyamide, in other words, decrease the toughness.