ABSTRACT Objective This study investigated the factors associated with satisfactory early postoperative wound conditions. Method A prospective study was conducted with patients (n=179) submitted to osteosynthesis in general, in a hospital orthopedics service. In the preoperative period, patients underwent laboratory exams and the surgical indications were based on the type of fracture and the patient’s clinical conditions. In the postoperative period, patients were evaluated based on the presence of complications and considering their surgical wounds. Chi-square, Fisher, Mann-Whitney, and Kruskal-Wallis tests were used in the analysis. To identify the factors associated with wound condition, univariate and multiple logistic regression analysis was used. Results In the univariate analysis, each transferring unit reduction increased the chance of satisfactory outcome by 1.1% (p=0.0306; OR= 0.989 (1.011); 95%CI= 0.978;0.999; 1.001;1.023). The presence of SAH increased 2.7 fold the chance of satisfactory outcome (p=0.0424; OR= 2,667; 95%CI= 1,034;6,877). Hip fracture increased 2.6 fold the chance of satisfactory outcome (p=0.0272; OR=2.593; IC95%=1.113; 6.039). And the absence of a compound fracture increased 5.5 fold the chance of satisfactory wound outcome (p=0.0004; OR=5,493; 95%CI=2,132;14,149). In the multiple analysis, patients with non compound fractures were 9.7 times more likely to experience a satisfactory outcome when compared to patients with compound fractures (p=0.0014; OR=9,687; 95%CI= 2,399; 39,125). Conclusion There was an inverse relationship between plasma proteins levels and satisfactory surgical wounds outcome. Only exposure remained associated with wound conditions. Level Of Evidence: II, Prospective Study. conditions n=179 n179 n 179 (n=179 general service period patient s Chisquare, Chisquare Chi square, square Chi-square Fisher MannWhitney, MannWhitney Mann Whitney, Whitney Mann-Whitney KruskalWallis Kruskal Wallis condition 11 1 1.1 p=0.0306 p00306 p 0 0306 (p=0.0306 OR 0989 989 0.98 1.011 1011 011 (1.011) 95CI CI 95 95%CI 0.9780.999 09780999 0.978 0.999 978 999 0.978;0.999 1.0011.023. 10011023 1.001 1.023 . 001 023 1.001;1.023) 27 2 7 2. p=0.0424 p00424 0424 (p=0.0424 2,667 2667 667 1,0346,877. 10346877 1,034 6,877 034 6 877 1,034;6,877) 26 p=0.0272 p00272 0272 (p=0.0272 OR=2.593 OR2593 593 IC95%=1.113 IC951113 IC IC95 113 6.039. 6039 6.039 039 6.039) 55 5 5. p=0.0004 p00004 0004 (p=0.0004 OR=5,493 OR5493 493 95%CI=2,13214,149. 95CI213214149 95%CI=2,132 14,149 132 14 149 95%CI=2,132;14,149) 97 9 9. p=0.0014 p00014 0014 (p=0.0014 OR=9,687 OR9687 687 2,399 2399 399 39,125. 39125 39,125 39 125 39,125) Evidence II Study n=17 n17 17 (n=17 1. p=0.030 p0030 030 (p=0.030 098 98 0.9 1.01 101 01 (1.011 9780 0.9780.99 0978099 0978 0.97 0999 0.99 99 0.978;0.99 0011 1.0011.023 1001102 1001 1.00 1023 1.02 00 02 1.001;1.023 p=0.042 p0042 042 (p=0.042 2,66 266 66 0346 1,0346,877 1034687 1034 1,03 6877 6,87 03 87 1,034;6,877 p=0.027 p0027 027 (p=0.027 OR=2.59 OR259 59 IC95%=1.11 IC95111 IC9 603 6.03 p=0.000 p0000 000 (p=0.000 OR=5,49 OR549 49 13214 95%CI=2,13214,149 95CI21321414 95CI2132 95%CI=2,13 14149 14,14 13 95%CI=2,132;14,149 p=0.001 p0001 (p=0.001 OR=9,68 OR968 68 2,39 239 3912 39,12 3 12 n=1 n1 (n=1 p=0.03 p003 (p=0.03 09 0. 1.0 10 (1.01 0.9780.9 097809 097 099 0.978;0.9 1.0011.02 100110 100 102 1.001;1.02 p=0.04 p004 04 (p=0.04 2,6 1,0346,87 103468 103 1,0 6,8 8 1,034;6,87 p=0.02 p002 (p=0.02 OR=2.5 OR25 IC95%=1.1 IC9511 60 6.0 p=0.00 p000 (p=0.00 OR=5,4 OR54 4 1321 95%CI=2,13214,14 95CI2132141 95CI213 95%CI=2,1 1414 14,1 95%CI=2,132;14,14 OR=9,6 OR96 2,3 23 391 39,1 n= (n= p=0.0 p00 (p=0.0 (1.0 0.9780. 09780 0.978;0. 1.0011.0 10011 1.001;1.0 2, 1,0346,8 10346 1, 6, 1,034;6,8 OR=2. OR2 IC95%=1. IC951 6. OR=5, OR5 95%CI=2,13214,1 95CI213214 95CI21 95%CI=2, 141 14, 95%CI=2,132;14,1 OR=9, OR9 39, (n p=0. p0 (p=0. (1. 0.9780 0.978;0 1.0011. 1.001;1. 1,0346, 1,034;6, OR=2 IC95%=1 OR=5 95%CI=2,13214, 95CI21321 95CI2 95%CI=2 95%CI=2,132;14, OR=9 p=0 (p=0 (1 0.978; 1.0011 1.001;1 1,0346 1,034;6 IC95%= 95%CI=2,13214 95%CI=2,132;14 p= (p= ( 1.001; 1,034; IC95% 95%CI=2,1321 95%CI=2,132;1 (p 95%CI=2,132;
RESUMO Objetivo Este estudo investigou os fatores associados à condição satisfatória de ferida pós-operatória precoce. Método Foi desenvolvido um estudo prospectivo com pacientes (n=179) submetidos a osteossínteses em geral, em um serviço de ortopedia hospitalar. No período pré-operatório os pacientes foram submetidos a exames laboratoriais e as indicações cirúrgicas foram baseadas no tipo de fratura e condições clínicas. No período pós-operatório, os pacientes foram avaliados conforme a presença de complicações e feridas operatórias. Foram utilizados na análise os testes Qui-quadrado, Fisher, Mann-Whitney, Kruskal-Wallis. Para identificar os fatores associados à condição da ferida, foi utilizada a análise de regressão logística univariada e múltipla. Resultados Na análise univariada, cada unidade a menos de transferrina, aumentou a chance de condição satisfatória em 1.1% (p= 0.0306; OR= 0.989 (1.011); IC95%= 0.978;0.999; 1.001;1.023). A presença de HAS aumentou a chance de condição satisfatória em 2.7 vezes (p=0.0424; OR= 2.667; IC95%= 1.034;6.877). Fratura de quadril aumentou a chance de condição satisfatória em 2.6 vezes (p=0.0272; OR=2.593; IC95%=1.113;6.039). E não apresentar fratura exposta, aumentou a chance de condição satisfatória da ferida em 5.5 vezes (p=0.0004; OR=5.493; IC95%=2.132;14.149). Na análise múltipla, fraturas sem exposição, apresentaram chance 9.7 vezes maior de apresentar condição satisfatória do que insatisfatória; quando comparadas às que apresentaram exposição (p=0.0014; OR=9.687; IC95%= 2,399; 39.125). Conclusão Houve uma relação inversa entre proteínas plasmáticas e presença de feridas operatórias satisfatórias. Apenas a exposição se manteve associada à condição da ferida. Nível de Evidência: II; Estudo Prospectivo. pósoperatória pós operatória precoce n=179 n179 n 179 (n=179 geral hospitalar préoperatório pré operatório clínicas pósoperatório, pósoperatório operatório, pós-operatório Quiquadrado, Quiquadrado Qui quadrado, quadrado Qui-quadrado Fisher MannWhitney, MannWhitney Mann Whitney, Whitney Mann-Whitney KruskalWallis. KruskalWallis Kruskal Wallis. Wallis Kruskal-Wallis múltipla transferrina 11 1 1.1 p= p (p 0.0306 00306 0 0306 OR 0989 989 0.98 1.011 1011 011 (1.011) IC95 IC IC95% 0.9780.999 09780999 0.978 0.999 978 999 0.978;0.999 1.0011.023. 10011023 1.001 1.023 . 001 023 1.001;1.023) 27 2 7 2. p=0.0424 p00424 0424 (p=0.0424 2.667 2667 667 1.0346.877. 10346877 1.034 6.877 034 6 877 1.034;6.877) 26 p=0.0272 p00272 0272 (p=0.0272 OR=2.593 OR2593 593 IC95%=1.1136.039. IC9511136039 IC95%=1.113 6.039 113 039 IC95%=1.113;6.039) exposta 55 5 5. p=0.0004 p00004 0004 (p=0.0004 OR=5.493 OR5493 493 IC95%=2.13214.149. IC95213214149 IC95%=2.132 14.149 132 14 149 IC95%=2.132;14.149) 97 9 9. insatisfatória p=0.0014 p00014 0014 (p=0.0014 OR=9.687 OR9687 687 2,399 2399 399 39.125. 39125 39.125 39 125 39.125) satisfatórias Evidência II Prospectivo n=17 n17 17 (n=17 1. 0.030 0030 030 098 98 0.9 1.01 101 01 (1.011 IC9 9780 0.9780.99 0978099 0978 0.97 0999 0.99 99 0.978;0.99 0011 1.0011.023 1001102 1001 1.00 1023 1.02 00 02 1.001;1.023 p=0.042 p0042 042 (p=0.042 2.66 266 66 0346 1.0346.877 1034687 1034 1.03 6877 6.87 03 87 1.034;6.877 p=0.027 p0027 027 (p=0.027 OR=2.59 OR259 59 1136 IC95%=1.1136.039 IC951113603 IC951113 IC95%=1.11 6039 6.03 IC95%=1.113;6.039 p=0.000 p0000 000 (p=0.000 OR=5.49 OR549 49 13214 IC95%=2.13214.149 IC9521321414 IC952132 IC95%=2.13 14149 14.14 13 IC95%=2.132;14.149 p=0.001 p0001 (p=0.001 OR=9.68 OR968 68 2,39 239 3912 39.12 3 12 n=1 n1 (n=1 0.03 003 09 0. 1.0 10 (1.01 0.9780.9 097809 097 099 0.978;0.9 1.0011.02 100110 100 102 1.001;1.02 p=0.04 p004 04 (p=0.04 1.0346.87 103468 103 6.8 8 1.034;6.87 p=0.02 p002 (p=0.02 OR=2.5 OR25 IC95%=1.1136.03 IC95111360 IC95111 IC95%=1.1 603 6.0 IC95%=1.113;6.03 p=0.00 p000 (p=0.00 OR=5.4 OR54 4 1321 IC95%=2.13214.14 IC952132141 IC95213 IC95%=2.1 1414 14.1 IC95%=2.132;14.14 OR=9.6 OR96 2,3 23 391 39.1 n= (n= 0.0 (1.0 0.9780. 09780 0.978;0. 1.0011.0 10011 1.001;1.0 p=0.0 p00 (p=0.0 1.0346.8 10346 6. 1.034;6.8 OR=2. OR2 IC95%=1.1136.0 IC9511136 IC9511 IC95%=1. 60 IC95%=1.113;6.0 OR=5. OR5 IC95%=2.13214.1 IC95213214 IC9521 IC95%=2. 141 14. IC95%=2.132;14.1 OR=9. OR9 2, 39. (n (1. 0.9780 0.978;0 1.0011. 1.001;1. p=0. p0 (p=0. 1.0346. 1.034;6. OR=2 IC95%=1.1136. IC951 IC95%=1 IC95%=1.113;6. OR=5 IC95%=2.13214. IC9521321 IC952 IC95%=2 IC95%=2.132;14. OR=9 (1 0.978; 1.0011 1.001;1 p=0 (p=0 1.0346 1.034;6 IC95%=1.1136 IC95%=1.113;6 IC95%=2.13214 IC95%=2.132;14 ( 1.001; 1.034; IC95%=1.113; IC95%=2.1321 IC95%=2.132;1 IC95%=2.132;