The present study is to investigate the influence of weight percentage of silicon carbide (SiC) (5,10 %, 15%) and particle size (10,20,40µm) of SiC and constant 2% of Molybdenum disulphide(MoS2)is reinforced with aluminium matrix. Wear performance of the composite was carried out through pin-on-disc method to calculate friction coefficient and wear resistance of the composites. The experiments were conducted by varying the sliding speed of (1.5,2.5 &3.5 m/s), loads (30,50&70N) with sliding distance ranges from (500, 1000& 1500m) under dry sliding conditions. Taguchi plan of experiments and ANOVA method was carried out to find the outcome of reinforcement ceramic particles, sliding distance, sliding speed, and applied load over the friction coefficient and wear rate. The result reveals that applied load and sliding distance are the most influencing factors for friction coefficient. Load and percentage of SiC indicates the most affecting factor for wear rate. Worn out surface of the composites were studied by optical microscopic image and Gwyddion software. To conclude, it was interfered that 15% weight percentage of SiC at 10µm offers better wear resistance and friction coefficient in AHMMCs.

ABSTRACT Introduction Radical nephrectomy (RN), a recommended treatment option for patients with Renal cell carcinoma (RCC) leads to an inevitable decline in global renal function. Pathological changes in the non-tumour parenchyma of the kidney may help predict the function of the remaining kidney. Materials and Methods Aim of this prospective, observational study was to find histopathological factors in the non-tumor renal parenchyma that could predict the decline in global renal function postoperatively and its association with co-morbidities like diabetes (DM). Data of consecutive patients undergoing RN from December-2013 to January-2015 was collected. Non-tumor parenchyma of the specimen was reported by a dedicated histopathologist. eGFR was calculated using Cockcroft-Gault formula before the surgery and at last follow up of at least 12 months. Results 73 RN specimens were analyzed. Mean follow up was 12.3 months. The mean decrease in eGFR was 22% (p=.0001). Percent decrease in eGFR did not show association with any of the histopathological parameters studied. DM was significantly associated with decrease in percent eGFR (p<0.05) and increase in arteriolar hyalinosis (p=0.004), Glomerulosclerosis (p=0.03) and Interstitial fibrosis/ Tubular atrophy (p=.0001). Maximum size of the tumor showed a negative correlation with percentage change in eGFR (p=.028). Conclusion Histological parameters in the non-tumour portion of the RN specimen may not be able to predict renal function outcome over a short follow up. However, presence of DM was associated with adverse pathological changes and significant decrease in renal function postoperatively.

Uma síntese estratégica de novas piperazinas sulfonil metilpirimidina envolvendo acoplamento Suzuki foi desenvolvida e as atividades farmacológicas dos compostos foram avaliadas. As reações foram realizadas pelo método convencional e apresentaram boas transformações dos grupos funcionais e elevados rendimentos. As estruturas dos novos compostos sintetizados foram estabelecidas por espectroscopia no infravermelho (IR), ressonância magnética nuclear (NMR) de ¹H e de 13C, e cromatografia líquida-espectrometria de massas (LC-MS) e análise elementar. Os compostos foram testados quanto à atividade antibacteriana in vitro contra as cepas bacterianas Escherichia coli e Staphylococcus aureus, à atividade antihelmíntica utilizando Pheretima posthuma e à atividade anti-inflamatória envolvendo o modelo de edema de pata de rato induzido pela carragena. Provou-se que alguns compostos são farmacóforos potentes.

A strategic synthesis of novel methylpyrimidine sulfonyl piperazines involving Suzuki coupling was designed and pharmacological activities of the compounds were evaluated. Reactions were carried out under conventional method and show good functional group transformations and high yields. Structures of the newly synthesized compounds were established by infrared spectroscopy (IR), ¹H and 13C nuclear magnetic resonance (NMR) and liquid chromatography-mass spectrometry (LC-MS) and elemental analysis. The compounds were tested for in vitro antibacterial activity against Escherichia coli and Staphylococcus aureus bacterial strains, anthelmintic activity using Pheretima posthuma and anti-inflammatory activity involving carrageenan induced rat paw edema model. Some compounds were proven to be potent pharmacophores.

Este trabalho descreve uma abordagem para dessimetrização de glicerol utilizando canforsulfonamida disponível como material de partida. A estratégia para síntese assimétrica de (R)/(S)-propranolol, (R)/(S)-naftopidila e (R)-monobutirina com formação de espirocetal por dessimetrização foi empregada e a reação de Mitsunobu foi utilizada para a formação de epóxido e éter. Esterificação de Steglich e CAN (nitrato de cério amônia) mediaram a desproteção de cetal como etapas chave na síntese. A abertura regioseletetiva do anel do epóxido forneceu a molécula desejada com bom rendimento e pureza ótica.

Herein, an approach for desymmetrization of glycerol by using a readily available camphorsulfonamide as a starting material is described. The strategy for asymmetric synthesis of (R)/(S)-propranolol, (R)/(S)-naftopidil and (R)-monobutyrin with spiroketal formation by desymmetrization was employed and Mitsunobu reaction was used for epoxide and ether formation. Steglich esterification and CAN (cerium ammonium nitrate) mediated ketal deprotection, were key steps in the synthesis. Regioselective ring opening of epoxide gave desired molecule with good overall yield and optical purity.