ABSTRACT Dengue, an infection characterized by recurrent epidemic spanning 3 to 5 years, stands out as a one of the most prominent problem due to its escalating case number and geographic extension. Despite its vast distribution, the disease occurs most intensely in the Americas and Southeast Asia. Within this scenario, it is imperative to carefully assess the potential repercussions of this epidemic on transplant activity. Although literature on this matter remains sparse, a review of probable and confirmed cases of dengue transmission through infected donors was carried out, addressing clinical characteristics and outcomes in recipients of such organs. Considering the strategies adopted in other countries that have already experienced dengue epidemics with the transmission of the virus through organ transplantation, the Comissão de Infecção em Transplante (COINT) da Associação Brasileira de Transplante (ABTO) delineates a protocol for screening potential donors and transplant candidates. This protocol involves the combined use of NS1/IgM on blood, alongise stringent criteria for evaluating donor and recipient suitability. Dengue years extension distribution Asia scenario activity sparse organs transplantation COINT (COINT ABTO (ABTO candidates NS1IgM NSIgM NS1 IgM NS blood suitability

RESUMO A dengue, infecção caracterizada por ciclos epidêmicos que se repetem a cada 3 a 5 anos, figura como um dos problemas de maior destaque, tendo em vista sua progressiva expansão em número de casos e extensão geográfica. Em que pese sua vasta distribuição geográfica, é nas Américas e Sudeste Asiático que a doença incide de forma mais intensa. No contexto de surtos e epidemias, as infecções transmitidas pelos doadores podem representar um grande desafio devido à falta de dados, na literatura, de uma política clara para triagem dos doadores e dos possíveis desfechos indesejáveis. Casos de transmissão provável e confirmada têm sido relatados em receptores de diferentes órgãos. Embora o total de casos descritos seja pequeno, é importante considerar a possibilidade de subnotificação e o aumento substancial do risco desse evento, especialmente nos períodos em que a transmissão da dengue atinge níveis epidêmicos na população. Com base na escassa literatura, porém baseada em estratégias adotadas em outros países que já experimentaram epidemias de dengue com transmissão do vírus por meio de transplante de órgãos, a Comissão de Infecção em Transplante (COINT) da Associação Brasileira de Transplante (ABTO) sugere triagem de doadores e candidatos a transplante com o uso combinado de NS1/IgM no sangue e critérios para o aceite do doador e do candidato. anos destaque geográfica intensa dados literatura indesejáveis órgãos pequeno evento população COINT (COINT ABTO (ABTO NS1IgM NSIgM NS1 IgM NS candidato

ABSTRACT: This in silico study aimed to evaluate the biomechanical behavior of a full-arch implant-supported prosthesis on titanium and zirconia monotype implants. A 3D mandible containing 1.0 mm thick cortical and cancellous bone was modeled. Four dental implants (3.3 x 10 mm) were inserted into the jaw model in each model. The implants consisted of Titanium (Ti-S group) and Zirconia Monotype/one-piece (Zr-S group). Fixed full-arch implant-supported prostheses were cemented onto the implant. The models were exported to the analysis software and divided into meshes composed of nodes and tetrahedral elements. All materials were considered isotropic, elastic, and homogeneous. Therefore, all contacts were considered bonded, the mandible model was fixed in all directions, applying a static structural axial load of 300 N on the bottom of the fossa of the left mola r teeth. Microstrain and von-Mises stress (MPa) were adopted as failure criteria. Comparable stress and strain values were shown in the peri-implant bone for both groups. However, the Ti-S group presented a lower stress value (1,155.8 MPa) than the Zr-S group (1,334.2 MPa). Regarding bone tissues, the Ti-S group presented 612 µε and the Zr-S group presented 254 µε. The highest strain peak was observed in bone tissues around the implant closer to the load for both groups. Evaluating monotype zirconia and titanium implants, it is suggested that the greater the rigidity of the implant, the greater the concentration of internal stre sses and the less dissipation to the surrounding tissues. Therefore, monotype ceramic implants composed of yttrium-stabilized tetragonal polycrystalline zirconia may be a viable alternative to titanium implants for full-arch prostheses.

RESUMEN: El objetivo de este estudio in silico fue evaluar el comportamiento biomecánico de una prótesis implanto soportada de arcada completa sobre implantes monotipo de titanio y zirconia. Se modeló una mandíbula en 3D que contenía tejido óseo cortical y esponjoso de 1,0 mm de espesor. En cada modelo, se insertaron cuatro implantes dentales (3,3 x 10 mm) en el modelo de mandíbula. Los implantes consistieron en Monotipo de Titanio y Zirconia. Sobre el implante se cementaron prótesis implanto soportadas de arcada completa fija. Los modelos se exportaron al software de análisis y se dividieron en mallas compuestas por nodos y elementos tetraédricos. Todos los materiales se consideraron isotrópicos, elásticos y homogéneos. Por lo tanto, todos los contactos se consideraron cementados, el modelo mandibular se fijó en todas las direcciones, aplicando una carga vertical estructural estática de 300 N en el fondo de la fosa de los dientes molares izquierdos. Se seleccionaron la microesfuerzo y la tensión de Von-Mises (MPa) como criterios de falla. Se mostraron valores de tensión y deformación comparables en el hueso periimplantario para ambos grupos. Sin embargo, el grupo Ti-S presentó un valor de estrés menor (1.155,8 MPa) que el grupo Zr-S (1.334,2 MPa). En cuanto a los tejidos óseos, el grupo Ti-S presentó 612 µε y el grupo Zr-S presentó 254 µε. La mayor concentración de deformación en el tejido óseo se observó en los tejidos alrededor del implante más cerca de la carga para ambos grupos. Al evaluar los implantes monotípicos de zirconia y titanio, se sugiere que cuanto mayor sea la rigidez del implante, mayor será la concentración de tensiones internas y menor la disipación a los tejidos circundantes. Por lo tanto, los implantes cerámicos monotipo compuestos de zirconia policristalina tetragonal estabilizada con itrio pueden ser una alternativa viable a los implantes de titanio para prótesis de arcada completa.

ABSTRACT: The present study proposed to describe, through a literature review, the use of new therapeutic management which allows for offering a better quality of life to individuals affected by these pathologies. A bibliographic search was conducted in the main health databases PUBMED (www.pubmed.gov) and Scholar Google (www.scholar.google.com.br), in which studies published from 1987 to 2023 were collected. In the first stage, the list of retrieved articles was examined by reading the titles and abstracts. In the second stage, the studies were selected by reading the full contents. Two authors (JDMM and DAQ) performed stages 1 and 2. Experimental, clinical, case-control, randomized controlled, and laboratory cohort studies, case reports, systematic reviews, and literature reviews, which were developed in living individuals, were included. Therefore, articles that did not deal with the subject in question, letters to the editor, opinion articles, duplicated literature in databases, and literature that did not address the variables under study, we re excluded. Contemporary dentistry uses alternative treatments capable of improving the patient's condition since a cure is not always possible. Therefore, the possibility of improving the quality of life becomes an important point to be reached. Evidence-based healthcare has made great advances in recent decades, especially in the areas of orofacial pain, TMD, and occlusion, especially related to orthodontic, prosthetic, and restorative care.

RESUMEN: En el presente estudio se propuso describir, a través de una revisión bibliográfica, el uso de nuevos manejos terapéuticos que permitan brindar una mejor calidad de vida a los individuos afectados por estas patologías. Se realizó una búsqueda bibliográfica en las principales bases de datos de salud PUBMED (www.pubmed.gov) y Scholar Google (www.scholar.google.com.br), en las que se recopilaron estudios publicados entre 1987 y 2023. En la primera etapa, se examinó la lista de artículos recuperados mediante la lectura de los títulos y resúmenes. En la segunda etapa, los estudios fueron seleccionados mediante la lectura del contenido completo. Dos autores (JDMM y DAQ) realizaron las etapas 1 y 2. Se incluyeron estudios de cohortes experimentales, clínicos, de casos y controles, controlados aleatorios y de laboratorio, informes de casos, revisiones sistemáticas y revisiones de la literatura, que se desarrollaron en individuos vivos. Por lo tanto, se excluyeron artículos que no trataran el tema en cuestión, cartas al editor, artículos de opinión, literatura duplicada en bases de datos y literatura que no abordara las variables en estudio. La odontología contemporánea utiliza tratamientos alternativos capaces de mejorar el estado del paciente, ya que no siempre es posible la curación. Por lo tanto, la posibilidad de mejorar la calidad de vida se convierte en un objetivo importante. La atención médica basada en la evidencia ha logrado grandes avances en las últimas décadas, especialmente en las áreas de dolor orofacial, TMD y oclusión, especialmente en relación con la atención de ortodoncia, prótesis y restauración.

Abstract The aim of this study was to investigate the impacts of COVID 19 on mental health among Health Sciences college students. This is a cross-sectional and quantitative study, the sample consisted of 618 university students of health sciences. Depressive symptoms were evaluated using the Patient Health Questionnaire 9 (PHQ-9). The prevalence of depressive symptoms was estimated and the relationship between severe depressive symptoms and associated factors was achieved through multivariate analysis of Poisson Regression. The prevalence of mild, moderate, or severe depressive symptoms was 87.2% among students, while the prevalence of severe depressive symptoms was 18.8%. The factors that were significantly associated with severe depressive symptoms were moderate to severe internet dependence (PR = 3.60), self-perceived health regular / poor (PR = 3.15), female gender (PR = 2, 11), sexual orientation (PR = 2.02), decreased family income during the COVID-19 Pandemic (PR = 1.87) and the presence of some chronic disease (PR = 1.77). The assessment of the prevalence of depressive symptoms among students of health sciences was high and, considering the potential underlying health commitment institutional policies should be outlined, aiming to promote and protect the mental health of this population, as well as mitigate the negative effects direct and indirect effects caused by COVID-19.

Resumo O objetivo deste estudo foi investigar os impactos da COVID-19 na saúde mental entre estudantes universitários de Ciências da Saúde. Trata-se de um estudo transversal e quantitativo, cuja amostra foi constituída por 618 estudantes universitários da área da saúde. Os sintomas depressivos foram avaliados por meio do Patient Health Questionnaire 9 (PHQ-9). A prevalência dos sintomas depressivos foi estimada e a relação entre sintomas depressivos severos e fatores associados foi obtida por meio de análise multivariada da Regressão de Poisson. A prevalência da sintomatologia depressiva, seja ela leve, moderada ou severa, foi de 87,2% entre os estudantes, enquanto a prevalência de sintomas depressivos severos foi de 18,8%. Os fatores que se associaram de forma significativa aos sintomas depressivos severos foram a dependência de internet moderada a grave (RP = 3,60), a autopercepção de saúde regular/ruim (RP = 3,15), o sexo feminino (RP = 2,11), orientação sexual (RP = 2,02), diminuição da renda familiar durante a Pandemia da COVID-19 (RP = 1,87) e presença de alguma doença crônica (RP = 1,77). A avaliação da prevalência de sintomas depressivos entre os estudantes de Ciências da Saúde foi elevada e, considerando o potencial comprometimento de saúde subjacente, políticas institucionais devem ser delineadas, visando promover e proteger a saúde mental dessa população, assim como mitigar os efeitos negativos diretos e indiretos causados pela COVID-19.

ABSTRACT Introduction: breast cancer is the cancer with the highest incidence in women in Brazil, representing 29.7% of all cancers. More than two thirds of women with breast cancer show expression for hormone receptors, and in these cases, hormone therapy with tamoxifen is indicated, which may represent a risk factor for the development of endometrial cancer (four-fold greater relative risk). Objective: this study aimed to evaluate the association of tamoxifen and the development of endometrial disturbances and to assess possible other associated risk factors. Patients and method: a total of 364 breast cancer patients were evaluated, 286 who used tamoxifen and 78 who did not use this hormone therapy. Results: patients who used tamoxifen had a mean follow-up time of 51.42 months similar to those without hormone therapy (p=0.081). A total of 21 (7.3%) women who used tamofixen and no cases among women without hormone therapy presented endometrial changes during follow-up (p=0.01). Despite information regarding obesity was available for only 270 women, obesity was also significantly associated with the development of endometrial changes (p=0.008). Conclusion: furthermore, the association between tamofixen and endometrial changes remained significant (p=0.039) after adjusting for obesity. Introduction Brazil 297 29 7 29.7 cancers receptors indicated fourfold four fold risk. . risk) Objective factors method 36 evaluated 28 Results followup follow up 5142 51 42 51.4 p=0.081. p0081 p p=0.081 0 081 (p=0.081) 2 7.3% 73 3 (7.3% p=0.01. p001 p=0.01 01 (p=0.01) 27 p=0.008. p0008 p=0.008 008 (p=0.008) Conclusion furthermore p=0.039 p0039 039 (p=0.039 29. 514 5 4 51. p008 p=0.08 08 (p=0.081 7.3 (7.3 p00 p=0.0 (p=0.01 p000 p=0.00 00 (p=0.008 p=0.03 p003 03 (p=0.03 (p=0.08 7. (7. p0 p=0. (p=0.0 (p=0.00 (7 p=0 (p=0. ( p= (p=0 (p= (p

RESUMO Introdução: o câncer da mama é o câncer de maior incidência no sexo feminino no Brasil, representando 29,7% de todos os cânceres. Mais de dois terços das mulheres com câncer da mama apresentam expressão para receptores hormonais, estando, nestes casos, indicada a terapia hormonal com tamoxifeno, que pode representar fator de risco para o desenvolvimento do câncer do endométrio (risco relativo quatro vezes maior). Objetivo: este trabalho teve como objetivo avaliar a associação entre o uso de tamoxifeno e o desenvolvimento de distúrbios endometriais bem como eventuais outros fatores associados. Pacientes e método: Estudo de coorte retrospectivo de 364 pacientes com câncer da mama, das quais 286 utilizaram tamoxifeno e 78 não utilizaram esta hormonioterapia. Resultados: pacientes que usaram tamoxifeno tiveram um seguimento médio de 51,42 meses, semelhante àquelas sem terapia hormonal (p=0,081). Um total de 21 (7,3%) mulheres que usaram tamofixeno e nenhuma mulher sem terapia hormonal apresentaram alterações endometriais durante o seguimento (p=0,01). Nas 270 mulheres que tinham informação sobre obesidade, esta se associou significantemente com o desenvolvimento de alterações endometriais (p=0,008). A associação entre tamofixeno e alterações endometriais permaneceu significante (p=0,039) após ajustar para interação com obesidade. Conclusão: o uso de tamoxifeno no tratamento do câncer da mama esteve associado ao maior risco para desenvolvimento de alterações endometriais especialmente quando associado à obesidade. Introdução Brasil 297 29 7 29,7 cânceres hormonais estando casos maior. . maior) Objetivo associados método 36 28 hormonioterapia Resultados 5142 51 42 51,4 meses p=0,081. p0081 p p=0,081 0 081 (p=0,081) 2 7,3% 73 3 (7,3% p=0,01. p001 p=0,01 01 (p=0,01) 27 obesidade p=0,008. p0008 p=0,008 008 (p=0,008) p=0,039 p0039 039 (p=0,039 Conclusão 29, 514 5 4 51, p008 p=0,08 08 (p=0,081 7,3 (7,3 p00 p=0,0 (p=0,01 p000 p=0,00 00 (p=0,008 p=0,03 p003 03 (p=0,03 (p=0,08 7, (7, p0 p=0, (p=0,0 (p=0,00 (7 p=0 (p=0, ( p= (p=0 (p= (p

Este estudio, de abordaje cualitativo, investigó cómo niños con cáncer comprendían la enfermedad y el tratamiento. Quince niños con cáncer, de seis a doce años de edad, en tratamiento quimioterápico o finalizado hacía menos de cinco meses, fueron entrevistados sobre su vivencia con relación al cáncer y a la quimioterapia. Para el análisis de las entrevistas se utilizó el método determinado por Bardin. Se identificó que los niños conocían su diagnóstico y tenían percepción de su gravedad. La quimioterapia fue asociada a la posibilidad de cura, pero los niños menores no entendían cómo un procedimiento que los dejaba peor y con malestar era la esperanza de cura. Los niños mayores, con leucemia, relataron inseguridad en relación con la eficacia del procedimiento. Escuchar a los niños fortaleció la necesidad de envolverlos en los procedimientos, teniendo como finalidad mejorar su calidad de vida. estudio cualitativo edad meses Bardin gravedad cura mayores leucemia procedimientos vida

This qualitative study investigated how children with cancer understand the illness and treatment. Fifteen children aged between six and 12 years who were undergoing chemotherapy or had completed the treatment less than five months before the study were interviewed about their experiences with the disease and chemotherapy. The interviews were analyzed using content analysis as proposed by Bardin. The findings showed that the children were aware of their diagnosis and the gravity of the disease. Chemotherapy was associated with the possibility of cure, but the younger children did not understand how a procedure that made them feel worse provided hope for cure. The older children with leukemia reported feeling insecure in relation to the efficacy of the procedure. The findings reinforce the need to involve children more in procedures with a view to improving quality of life. 1 Bardin cure life

Este estudo de abordagem qualitativa investigou como crianças com câncer compreendiam a doença e o tratamento. Quinze crianças com câncer, de 6 a 12 anos de idade, em tratamento quimioterápico ou finalizado há menos de cinco meses, foram entrevistadas sobre sua vivência em relação ao câncer e à quimioterapia. Para análise das entrevistas foi utilizado o método preconizado por Bardin. Identificou-se que as crianças conheciam seu diagnóstico e tinham percepção de sua gravidade. A quimioterapia foi associada à possibilidade de cura, mas crianças mais novas não compreendiam como um procedimento que gerava piora e mal-estar era a esperança de cura. Crianças mais velhas, com leucemia, relataram insegurança quanto à eficácia do tratamento. Ouvir as crianças fortaleceu a necessidade de envolvê-las nos procedimentos a fim de melhorar sua qualidade de vida. 1 idade meses Bardin Identificouse Identificou se gravidade cura malestar mal estar velhas leucemia envolvêlas envolvê las vida

Abstract Fetal programming suggests that maternal stimulation and nutrition during the period of fetal development can program the progeny. Conjugated linoleic acid (CLA), an isomer of linoleic acid, has been characterized in several aspects, but few studies have been performed on its involvement in reproduction and fetal programming. The aim of this study was to evaluate the F1, F2 and F3 progeny of female mice supplemented with CLA during the pregestational and gestational periods with respect to biometric and reproductive parameters, as well as ovarian morphophysiology. The F1 progeny of mothers supplemented with CLA exhibited stable weight gain, while the F2 progeny showed no effects (P=0.0187 and P=0.0245, respectively). A reduction in Lee's Index was observed in both generations at the second post-weaning evaluation week in the animals treated with CLA (P=0.0100 and P=0.0078, respectively). The F2 generation showed an increase in the anogenital index in both sexes of the animals treated with CLA (P= 0.0114 and P<0.0001, female and male respectively). CLA administration to mothers did not affect any of the following in their progeny: ovarian follicle mobilization (P>0.05), follicle number (P>0.05) and the integrated density of the lipid content of oocytes included in antral follicles (P>0.05). This study evaluated the use of CLA in mothers and found that it did not affect the progeny regarding murine reproductive performance, suggesting that this supplement can be used safely. CLA, , (CLA) aspects F parameters morphophysiology gain P=0.0187 P00187 P 0 0187 (P=0.018 P00245 0245 P=0.0245 respectively. respectively . respectively) Lees Lee s postweaning post weaning P=0.0100 P00100 0100 (P=0.010 P00078 0078 P=0.0078 P= (P 00114 0114 0.011 P00001 0001 P<0.0001 P>0.05, P005 P>0.05 05 (P>0.05 P>0.05. performance safely (CLA P=0.018 P0018 018 (P=0.01 P0024 024 P=0.024 P=0.010 P0010 010 P0007 007 P=0.007 0011 011 0.01 P0000 000 P<0.000 P00 P>0.0 (P>0.0 P=0.01 P001 01 (P=0.0 P002 02 P=0.02 P000 00 P=0.00 001 0.0 P<0.00 P0 P>0. (P>0. P=0.0 (P=0. 0. P<0.0 P>0 (P>0 P=0. (P=0 P<0. P> (P> P=0 P<0 P<

RESUMO Contextualização: Desde maio de 2022, casos de monkeypox (varíola dos macacos ou mpox) foram relatados em vários países, com evidências de transmissão comunitária. No cenário atual, temos transmissão identificada em diferentes continentes, relacionada com disseminação local do vírus por contato íntimo inter-humano. Objetivo: O objetivo desse artigo é informar a comunidade transplantadora sobre as eventuais implicações da doença para a população de receptores de transplantes e seus doadores. Método: Nesse artigo apresenta-se as orientações para adequar a avaliação de doadores e de candidatos a transplantes de órgãos, tendo em vista os riscos potenciais decorrentes da emergência de mpox em nosso meio. É importante considerar que este documento reflete a opinião de especialistas diante das escassas evidências atualmente disponíveis. Resultados e Conclusões: As recomendações de manejo e avaliação do doador baseiam-se no risco potencial da transmissão do vírux MPXV. Estima-se que o risco de transmissão pelo transplante seja baixo, levando-se em conta a incerteza sobre a duração da viremia em pacientes com mpox e a presença de vírus viável em células e tecidos. Recomenda-se, no entanto, que os médicos responsáveis pelo paciente estejam alerta para as evidências de infecção e que acionem ou notifiquem as instituições caso haja indícios de transmissão pelo transplante. Contextualização 2022 varíola países comunitária atual continentes interhumano. interhumano inter humano. humano inter-humano Objetivo Método apresentase apresenta se órgãos meio disponíveis Conclusões baseiamse baseiam MPXV Estimase Estima baixo levandose levando tecidos Recomendase, Recomendase Recomenda se, Recomenda-se entanto 202 20 2

ABSTRACT Contextualization: Since May 2022, cases of monkeypox (mpox) have been reported in several countries, with evidence of community transmission. In the current scenario, transmission has been identified in different continents, related to the local spread of the virus by intimate inter-human contact. Objective: The purpose of this article is to inform the transplant community about the possible implications of the disease for the population of transplant recipients and their donors. Method: This article presents guidelines for adapting the evaluation of donors and candidates for organ transplants, bearing in mind the potential risks resulting from the emergence of mpox in our midst. It is important to consider that this document reflects the opinion of specialists given the scarce evidence currently available. Results and Conclusions: Donor assessment and management recommendations are based on the potential risk of monkeypox virus (MPXV) transmission. The risk of transmission by transplantation is estimated to be low, taking into account the uncertainty about the duration of viremia in patients with mpox and the presence of viable virus in cells and tissues. It is recommended, however, that the physicians responsible for the patient are alert to evidence of infection and that they activate or notify the institutions in case there are indications of transmission through the transplant. Contextualization 2022 (mpox countries scenario continents interhuman inter human contact Objective Method transplants midst available Conclusions MPXV (MPXV low tissues recommended however 202 20 2

Este estudo de abordagem qualitativa investigou como crianças com câncer compreendiam a doença e o tratamento. Quinze crianças com câncer, de 6 a 12 anos de idade, em tratamento quimioterápico ou finalizado há menos de cinco meses, foram entrevistadas sobre sua vivência em relação ao câncer e à quimioterapia. Para análise das entrevistas foi utilizado o método preconizado por Bardin. Identificou-se que as crianças conheciam seu diagnóstico e tinham percepção de sua gravidade. A quimioterapia foi associada à possibilidade de cura, mas crianças mais novas não compreendiam como um procedimento que gerava piora e mal-estar era a esperança de cura. Crianças mais velhas, com leucemia, relataram insegurança quanto à eficácia do tratamento. Ouvir as crianças fortaleceu a necessidade de envolvê-las nos procedimentos a fim de melhorar sua qualidade de vida.

Este estudio, de abordaje cualitativo, investigó cómo niños con cáncer comprendían la enfermedad y el tratamiento. Quince niños con cáncer, de seis a doce años de edad, en tratamiento quimioterápico o finalizado hacía menos de cinco meses, fueron entrevistados sobre su vivencia con relación al cáncer y a la quimioterapia. Para el análisis de las entrevistas se utilizó el método determinado por Bardin. Se identificó que los niños conocían su diagnóstico y tenían percepción de su gravedad. La quimioterapia fue asociada a la posibilidad de cura, pero los niños menores no entendían cómo un procedimiento que los dejaba peor y con malestar era la esperanza de cura. Los niños mayores, con leucemia, relataron inseguridad en relación con la eficacia del procedimiento. Escuchar a los niños fortaleció la necesidad de envolverlos en los procedimientos, teniendo como finalidad mejorar su calidad de vida.

This qualitative study investigated how children with cancer understand the illness and treatment. Fifteen children aged between six and 12 years who were undergoing chemotherapy or had completed the treatment less than five months before the study were interviewed about their experiences with the disease and chemotherapy. The interviews were analyzed using content analysis as proposed by Bardin. The findings showed that the children were aware of their diagnosis and the gravity of the disease. Chemotherapy was associated with the possibility of cure, but the younger children did not understand how a procedure that made them feel worse provided hope for cure. The older children with leukemia reported feeling insecure in relation to the efficacy of the procedure. The findings reinforce the need to involve children more in procedures with a view to improving quality of life.

ABSTRACT: The aim of this study was to evaluate the dental and periodontal condition of alcohol-dependents from a Brazilian Recovery Center. Sixty male individuals (30 alcoholic and 30 non-alcoholic) and aged between 32 and 72 years old were clinically evaluated. Interviews, dental and periodontal clinical examinations were obtained from all participants. The Pearson Chi-Square Test and Exact Fisher test were used to compare categorical data. The t-Student’s test was adopted for non-categorical data. Multiple logistic regressions were used to evaluate the association of variables in the groups. The alcoholics were younger, consumed more tobacco, had lower frequency of tooth brushing and dental flossing, higher number of missing and decayed teeth, more residual root, and more teeth with presence of visible plaque index (OR = 0.5, 95 % Cl = 4.4 to 5.5), when compared to the non-alcoholics. Alcoholics at the Recovery Center performed poor oral hygiene, had higher number of sites with periodontal disease, and worse oral hygiene than non-alcoholic individuals. As regards professional follow-up, there was similarity between the groups evaluated.

RESUMEN: El objetivo de este estudio fue evaluar las condiciones dentales y periodontales de los alcohólicos de un Centro de Recuperación de Brasil. Sesenta hombres (30 alcohólicos y 30 no alcohólicos) y con edades comprendidas entre 32 y 72 años fueron evaluados clínicamente. Se obtuvieron entrevistas, exámenes clínicos dentales y periodontales de todos los participantes. La prueba de Chi-cuadrado de Pearson y la prueba exacta de Fisher se utilizaron para comparar datos categóricos. La prueba de t-Student se adoptó para datos no categóricos. Se utilizaron regresiones logísticas múltiples para evaluar la asociación de variables en los grupos. Los alcohólicos eran más jóvenes, consumían más tabaco, tenían menor frecuencia de cepillado dental y uso de hilo dental, mayor número de dientes perdidos y cariados, más raíz residual y más dientes con presencia de índice de placa visible (OR = 0,5, 95 % Cl = 4,4 a 5,5), en comparación con los no alcohólicos. Los alcohólicos en el Centro de Recuperación realizan una mala higiene bucal, tenían un mayor número de sitios con enfermedad periodontal y una peor higiene bucal que los no alcohólicos. En cuanto al seguimiento profesional, hubo similitud entre los grupos evaluados.

ABSTRACT: The aim of this study was to evaluate the influence of overtorque on integrity, strength and stress on external hexagonal implants (EH), with two different grades (N=10): conventional (C), grade 4; and modified (M), grade 4 with thermal treatment. The dimensions of EH were 3.75 x 13 mm; the specimens were fixed and submitted to SEM analysis and image acquisition. The abutment was then retained with 70 N/cm, re-analyzed by SEM, and a second image was obtained. The images were analyzed by Image J software (1.44o- NIH, USA) for dimensional variations measurement on surface of the hexagonal area. The finite element method was applied with a similar compliance to calculate the resultant stress (MPa) during the torque. Results were statistically analyzed with t-student test (5 %). The dimensional accuracy of M (0.22 mm2) was statistically significant (p<0.05). Minimum principal stress and von-Mises stress of C (-19.95 MPa, -19.94 MPa), were lower than M values (-55.83 MPa, -55.96 MPa), respectively. However, the M group showed lower deformation than C group. Therefore, more rigid titanium alloy is a promising alternative to avoid plastic deformation of prosthetic connec tions even concentrating higher stress magnitude on its structure.

RESUMEN: El objetivo de este estudio fue evaluar la influencia del sobrepar en la integridad, la fuerza y la tensión en los implantes hexagonales externos (EH), con dos grados diferentes (N = 10): convencional (C), grado 4; y modificado (M), grado 4 con tratamiento térmico. Las dimensiones de EH eran 3,75 de diámetro x 13 mm de longitud; las muestras se fijaron y se sometieron a análisis SEM y adquisición de imágenes. A continuación, el pilar se retuvo con 70 N / cm, se volvió a analizar por SEM y se obtuvo una segunda imagen. Las imágenes se analizaron con el software Image J (1.44o-NIH, EE. UU.) Para medir las variaciones dimensionales en la superficie superior del área hexagonal, que fue causada por un par excesivo. El método de los elementos finitos se aplicó con un cumplimiento similar para calcular la tensión resultante (MPa) durante el par. Los resultados se analizaron estadísticamente con la prueba t-student (5 %). La precisión dimensional de M (0,22 mm2) fue estadísticamente significativa (p <0,05). La tensión principal mínima y la tensión de von-Mises de C (-19,95 MPa, -19,94 MPa), fueron inferiores a los valores de M (-55,83 MPa, -55,96 MPa), respectivamente. Sin embargo, el hexágono del grupo M mostró menor deformación que el grupo C. Por lo tanto, la aleación de titanio más rígida es una alternativa prometedora para evitar la deformación plástica de las conexiones protésicas incluso concentrando una mayor magnitud de tensión en su estructura.

ABSTRACT: To evaluate the stresses generated in upper premolars rehabilitated with ceramic fragments (table-top) of lithium disilicate on the occlusal surface. An upper premolar was modeled following its anatomical references using computer aided design software (Rhinoceros version 5.0 SR8, USA). The dental tissues were individually designed containing enamel, dentin and periodontal ligament. The main anatomical points were used as parameters for model creation. Ceramic fragments were modeled varying their maximum thicknesses as: 0.5 mm, 1.0 mm and 1.5 mm. Solid geometries were exported to the analysis software (ANSYS 17.2, USA) in STEP format. The materials were considered isotropic, homogeneous and linear, and the values of the elastic modulus of the materials and structures were used to perform a static structural mechanical analysis. The set was submitted to 200 N load. The system fixation was defined on the basis of the three- dimensional model, and the results were obtained in MPa according to the failure criteria of the analyzed materials (tensile stress). Occlusal restoration was not detrimental to mechanical behavior. Stress distribution in the internal region of the restoration was similar between the groups. Thicker fragments presented a lower concentration of tensile stress, therefore suggesting better prognosis in attenuating tensile stresses in the tooth region. More conservative occlusal ceramic fragments presented worse prognosis. However, all evaluated thickness for table-tops support the occlusal rehabilitation of upper premolars when submitted to 200 N loading.

RESUMEN: El objetivo fue evaluar las tensiones generadas en los premolares superiores rehabilitados con fragmentos cerámicos (tablero) de disilicato de litio en la superficie oclusal. Se modeló un premolar superior siguiendo sus referencias anatómicas utilizando un software de diseño asistido por computadora (Rhinoceros versión 5.0 SR8, EE. UU.). Los tejidos dentales se moldearon individualmente conteniendo esmalte, dentina y ligamento periodontal. Los principales puntos anatómicos se utilizaron como parámetros para la creación del modelo. Los fragmentos cerámicos se modelaron variando sus espesores máximos como: 0,5 mm, 1,0 mm y 1,5 mm. Las geometrías sólidas se exportaron al software de análisis (ANSYS 17.2, EE. UU.) En formato STEP. Los materiales se consideraron isotrópicos, homogéneos y lineales, y los valores del módulo elástico de los materiales y estructuras se utilizaron para realizar un análisis mecánico estructural estático. El conjunto se sometió a una carga de 200 N. La fijación del sistema se definió a partir del modelo tridimensional, y los resultados se obtuvieron en MPa según los criterios de falla de los materiales analizados (tensión de tracción). La restauración oclusal no perjudica el comportamiento mecánico. La distribución de la tensión en la región interna de la restauración es similar entre los grupos. Los fragmentos más gruesos presentaron una menor concentración de tensión de tracción, lo que sugiere un mejor pronóstico en la atenuación de las tensiones de tracción en la región dentaria. Los fragmentos cerámicos oclusales más conservadores presentaron peor pronóstico. Sin embargo, todos los espesores evaluados para tableros de mesa en disilicato de litio apoyan la rehabilitación oclusal de los premolares superiores cuando se someten a una carga de 200 N.

ABSTRACT: The present study aims to describe through a literature review, the main types of noble and non-noble alloys in dentistry looking to identify the adhesion mechanisms, compositions and mechanical properties, and its applicability as a rehabilitation resource nowadays. A bibliographic search was conducted in the main health databases PUBMED (www.pubmed.gov) and Scholar Google (www.scholar.google.com.br), in which studies published from 1971 to 2021 were collected. Laboratory studies, case reports, systematic and literature reviews, which were developed in living individuals. Articles that did not deal with metal alloys and its use in dentistry were excluded. Through the review, it was possible to ver ify that all works presented the metal alloys and their main properties, indicating that they are divided into three main types: hi gh noble alloys, noble alloys and base metal alloys differing in their levels of constituent noble metals. Several alloys and meta ls are available for the dental market each presenting advantages and disadvantages, mainly based on its specific composition.Continuous research and development are resulting in the production of new technologies and products, giving dental surgeons even more options in the design and manufacture of restorations using metal alloys and understanding that these resources will still be viable alternatives in oral rehabilitations. However, further studies on metal alloys are needed to better understand this subject.

RESUMEN: El presente trabajo tuvo como objetivo describir a través de una revisión de la literatura, los principales tipos de aleaciones nobles y no nobles utilizados en odontología buscando identificar los mecanismos de adhesión, composiciones y propiedades mecánicas, así como reflejar su aplicabilidad como recurso rehabilitador en la actualidad. Realizamos una búsqueda bibliográfica em las principales bases de datos de salud PUBMED (www.pubmed.gov) y Scholar Google (www.scholar.google.com.br), en la que se recopilaron estudios publicados desde 1971 hasta 2021. Estudios de laboratorio, informes de casos, revisiones sistemáticas y bibliográficas, que se desarrollaron en individuos vivos. Sin embargo, se excluyeron los artículos que no trataban sobre aleaciones metálicas y su uso en odontología. Se pudo observar que todos los trabajos presentaban las aleaciones metálicas y sus principales propiedades indicando que se estas dividen en tres tipos principales: aleaciones altamente nobles, aleaciones nobles y aleaciones de metales base que difierenen sus niveles de metales nobles constituyentes. Hay varias aleaciones y metales disponibles para el mercado dental, cada uno presenta ventajas y desventajas, principalmente en función de su composición específica. La investigación y el desarrollo continuo están dando como resultado la producción de nuevas tecnologías y productos, brindando a los cirujanos dentistas aún más opciones en el diseño y fabricación de las restauraciones, utilizando aleaciones metálicas y, permite concluir que estos recursos seguirán siendo alternativas viables en los tratamientos de rehabilitación. Sin embargo, se necesitan más estudios sobre el tema abordado en el trabajo, para una comprensión más profunda del tema.

ABSTRACT: The aim of this study was to identify the incidence of fractures in single crowns placed in individuals with chronic tooth wear. The sample selection was performed based on the evaluation of 218 patient records rehabilitated with single crowns placed by the same professional from a private clinic. After exclusion criteria, 43 individuals (18 males and 25 females) were included and a total of 112 single crowns distributed in both jaws. Three ceramic systems were evaluated: 34 feldspathic all-ceramic, 38 metal-ceramic with a core in gold electropositive alloy, and 40 In-Ceram Alumina. The intraoral photograph analysis adopted a diagnosis method of tooth wear according to the morphological variations of the teeth. Of the 112 crowns evaluated, 47 were placed in male and 65 in female patients, aged between 21 to 74 years (mean 27.5 years old). The variables gender (p = 0.83), presence of chronic tooth wear (p = 0.91), ceramic system (p = 0.24) and crown location (p = 0.86) did not present a statistically difference. However, the variables pulp vitality (p = 0.04) and survi val time (p = 0.01) presented a statistically significant difference. The evaluated ceramic systems can be considered as alternativ es of restorative material, even in individuals with clinical characteristics suggestive of chronic tooth wear.

RESUMEN: El objetivo de este estudio fue identificar la incidencia de fracturas en coronas individuales colocadas en individuos con desgaste dental crónico. La selección de la muestra se realizó en base a la evaluación de 218 registros de pacientes rehabilitados con coronas individuales colocadas entre 1999 y 2009 por el mismo profesional de una clínica privada. Después de analizar los criterios de exclusión, se incluyeron 43 individuos (18 hombres y 25 mujeres) y un total de 112 coronas individuales distribuidas en ambas mandíbulas. Este estudio evaluó coronas hechas de tres sistemas cerámicos: 34 de cerámica totalmente feldespática, 38 de cerámica de metal con un núcleo de aleación electropositiva de oro y 40 de alúmina enceram. El análisis de la fotografía intraoral adoptó un método de diagnóstico del desgaste dental de acuerdo con las variaciones morfológicas de los dientes. De las 112 coronas evaluadas, 47 se colocaron en hombres y 65 en mujeres, con edades comprendidas entre 21 y 74 años (media de 27,5 años). Con respecto a las coronas individuales, las variables género (p = 0,83), presencia de desgaste dental crónico (p = 0,91), sistema cerámico (p = 0,24) y ubicación de la corona (p = 0,86) no presentaron una diferencia estadísticamente significativa. Sin embargo, las variables vitalidad pulpar (p = 0.04) y tiempo de supervivencia (p = 0.01) presentaron una diferencia estadísticamente significativa. Los sistemas cerámicos evaluados pueden considerarse como alternativas de material restaurador, incluso en individuos con características clínicas que sugieren desgaste dental crónico.

ABSTRACT: This study aims to evaluate the physical, chemical, mechanical and optical properties of Bulk-Fill resin, in relation to the literature and its proper clinical uses. A bibliographic search was performed in the main health databases PUBMED (www.pubmed.gov) and Scholar Google (www.scholar.google.com.br), in which articles published from 1994 to 2020 were collected. Laboratory studies, case reports, systematic reviews and literature reviews, which were developed in living individuals, were included. Therefore, articles that did not deal with the characteristics of the Bulk-Fill resin and its proper clinical uses were excluded. The use of Bulk-Fill resin has been progressively increasing over the years, presenting good properties, achieving success in clinical performance, ease of handling and thus has become the material of choice for dentists. In addition, its longevity demonstrates durability with mechanical properties and resistance to tooth structure. Bulk - Fill resins have characteristics similar to traditional composite resins, when performed according the usage protocol. With the use of this group of resins in a single increment, possible failures that occur during the restorative procedure can be minimized, such as: less chance of incorporating bubbles and a volumetric contraction with less stress on the interface.

RESUMEN: Este estudio tuvo como objetivo evaluar las propiedades físicas, químicas, mecánicas y ópticas de la resina Bulk-Fill, en relación con la literatura y sus usos clínicos apropiados. Realizamos una búsqueda bibliográfica en las bases de datos de salud PUBMED (www.pubmed.gov) y Scholar Google (www.scholar.google.com.br), en la que se recopilaron trabajos que se publicaron entre 1994 y 2020. Fueron incluidos estudios de laboratorio, informes de casos, revisiones sistemáticas y revisiones de literatura, desarrollados en individuos vivos. Por tanto, se excluyeron los artículos que no trataban las características de la resina Bulk-Fill y sus usos clínicos adecuados. El uso de la resina Bulk-Fill ha ido aumentando progresivamente a lo largo de los años, presentando buenas propiedades, logrando éxito en el rendimiento clínico, facilidad de manejo y, por lo tanto, se ha convertido en el material elegido por los dentistas. Además, su longevidad demuestra durabilidad, con propiedades mecánicas y resistencia a la estructura dental.Las resinas Bulk-Fill tienen características similares a las resinas compuestas tradicionales, cuando se realizan siguiendo el protocolo de uso. Con el uso de este grupo de resinas mono incremental, es posible eliminar el paso de varios incrementos, disminuyendo a su vez el tiempo clínico. Además, se pueden minimizar las posibles fallas que se producen durante el procedimiento de restauración, tales como: menos posibilidades de incorporar burbujas y una contracción volumétrica con menos estrés en la interfaz.