Abstract Indicator species are frequently used to monitor restoration areas. However, species of conservation concern are usually absent in highly fragmented landscapes, making the selection of indicator species a challenging task. Here, we select indicator species of birds and mammals to be used for the evaluation of restoration sites in a highly fragmented landscape, the Capivara-Taquaruçu Dams region located in north Paraná, Brazil. By using the Index of Biotic Integrity (IBI), we show that the Capivara-Taquaruçu Dams landscape has low IBI values and bird richness when compared with two other landscapes in the north of Paraná. Therefore, we used the Individual Indicate Value to identify birds and mammals associated with forest fragments in the Capivara-Taquaruçu Dams landscape. Six bird and four mammal species were selected as indicators of forest fragments, none of which were of conservation concern. However, monitoring of these species could help evaluate the recovery of restoration sites in the Capivara-Taquaruçu Dams region. Lastly, several species of birds and mammals were frequently recorded in the restoration sites, including vulnerable species such as the lowland tapir (Tapirus terrestris). This is indicative that restoration sites can be important habitats in highly fragmented landscapes despite the loss of biodiversity.

Abstract The municipality of São Paulo has historically been marked by a heterogeneous implementation and coexistence of conflicting models of SUS management and Primary Health Care (PHC). The administration of health services management contracts was consolidated and associated with a productivist rationale. The selective PHC weaknesses tend to be pronounced during the COVID-19 pandemic. Thus, the present article aims to analyze work management and care in PHC during the COVID-19 pandemic in the municipality of São Paulo through a multicenter qualitative research anchored in the Paideia theoretical framework. We conducted 31 in-depth interviews with PHC clients and workers, along with participant observation. We noted the municipal management’s authoritarian and managerialist stance when conducting the responses, with little room for listening and dialogue. We identified weakened collective spaces and service-community bond, bureaucratization and precariousness of work processes, and NASF’s dismantling. In this setting, care was characterized by significantly reducing the expanded and shared clinical practice and the distancing from the territorial and community-based PHC guidelines.

Resumo O município de São Paulo historicamente foi marcado pela heterogeneidade da implementação pela coexistência de modelos conflitivos de gestão do SUS e de atenção na Atenção Primária à Saúde (APS). Consolidou-se a administração via contratos de gestão dos serviços de saúde, associada a uma lógica produtivista. Durante a pandemia de COVID-19, as fragilidades de uma APS seletiva tendem a ser pronunciadas. Assim, o presente artigo tem como objetivo analisar a gestão do trabalho e o cuidado na APS durante a pandemia de COVID-19 no município de São Paulo, em pesquisa qualitativa multicêntrica, ancorada no referencial teórico Paideia. Foram realizadas 31 entrevistas em profundidade com usuários e trabalhadores da APS e observação participante. Observou-se postura autoritária e gerencialista da gestão municipal na condução das respostas, com pouco espaço para escuta e diálogo. Notou-se enfraquecimento dos espaços coletivos e do vínculo entre serviço e comunidade; burocratização e precarização dos processos de trabalho e desmantelamento do NASF. Neste cenário, o cuidado caracterizou-se pela redução expressiva da clínica ampliada, compartilhada e pelo distanciamento das diretrizes da APS de base territorial e comunitária.

Resumo O município de São Paulo historicamente foi marcado pela heterogeneidade da implementação pela coexistência de modelos conflitivos de gestão do SUS e de atenção na Atenção Primária à Saúde (APS). Consolidou-se a administração via contratos de gestão dos serviços de saúde, associada a uma lógica produtivista. Durante a pandemia de COVID-19, as fragilidades de uma APS seletiva tendem a ser pronunciadas. Assim, o presente artigo tem como objetivo analisar a gestão do trabalho e o cuidado na APS durante a pandemia de COVID-19 no município de São Paulo, em pesquisa qualitativa multicêntrica, ancorada no referencial teórico Paideia. Foram realizadas 31 entrevistas em profundidade com usuários e trabalhadores da APS e observação participante. Observou-se postura autoritária e gerencialista da gestão municipal na condução das respostas, com pouco espaço para escuta e diálogo. Notou-se enfraquecimento dos espaços coletivos e do vínculo entre serviço e comunidade; burocratização e precarização dos processos de trabalho e desmantelamento do NASF. Neste cenário, o cuidado caracterizou-se pela redução expressiva da clínica ampliada, compartilhada e pelo distanciamento das diretrizes da APS de base territorial e comunitária.

Abstract The municipality of São Paulo has historically been marked by a heterogeneous implementation and coexistence of conflicting models of SUS management and Primary Health Care (PHC). The administration of health services management contracts was consolidated and associated with a productivist rationale. The selective PHC weaknesses tend to be pronounced during the COVID-19 pandemic. Thus, the present article aims to analyze work management and care in PHC during the COVID-19 pandemic in the municipality of São Paulo through a multicenter qualitative research anchored in the Paideia theoretical framework. We conducted 31 in-depth interviews with PHC clients and workers, along with participant observation. We noted the municipal management’s authoritarian and managerialist stance when conducting the responses, with little room for listening and dialogue. We identified weakened collective spaces and service-community bond, bureaucratization and precariousness of work processes, and NASF’s dismantling. In this setting, care was characterized by significantly reducing the expanded and shared clinical practice and the distancing from the territorial and community-based PHC guidelines.

RESUMO JUSTIFICATIVA E OBJETIVOS: Mastectomia com linfadenectomia é uma cirurgia que causa dor moderada ou intensa no pós-operatório imediato. Muitos fármacos adjuvantes, seguros, que promovem boa analgesia e com poucos efeitos adversos têm sido pesquisados. A pregabalina e o sulfato de magnésio são fármacos que promovem analgesia com poucos efeitos adversos. O objetivo deste estudo foi avaliar o efeito analgésico da pregabalina e do sulfato de magnésio no pós-operatório de mastectomia com linfadenectomia axilar. MÉTODOS: Estudo randomizado e duplo-cego envolvendo 80 pacientes submetidas à mastectomia com linfadenectomia axilar sob anestesia geral. As pacientes foram divididas em quatro grupos: Controle (GC, não receberam o fármaco adjuvante proposto); Magnésio+Placebo (GM, receberam sulfato de magnésio durante a anestesia); Pregabalina+Magnésio (GP+M, receberam magnésio adicionado a pregabalina 150 mg antes e 12 h após a cirurgia); e Pregabalina+Placebo (GP, receberam a pregabalina). Todas as pacientes responderam o Self-Report Questionnaire 20 (SRQ-20) para rastrear possível transtorno mental e foram seguidas, monitorando o estado físico 1h, 12h e 24h após a cirurgia, através de anamnese, questionário de dor, consumo de opioides e presença de complicações e/ou eventos adversos como náusea, vômito e sonolência. A randomização foi realizada por meio de envelopes opacos e selados sem o conhecimento do anestesiologista (pesquisador) e do paciente. RESULTADOS: Foram randomizadas 20 pacientes para cada grupo, as quais foram analisadas ao fim do estudo. O número de pacientes apresentando dor ausente/leve no GP+M foi significantemente maior que nos GC, GM e GP após uma hora. Após 12 horas, GP+M e GP apresentaram maior número de pacientes com dor ausente/leve que GC e GM. Em 24 horas do pós-operatório, todos os pacientes de todos os grupos avaliados não apresentaram dor moderada/severa. Não houve diferença na frequência de pacientes apresentando náusea ou vômito, nem nos escores da avaliação do sono após a cirurgia nos quatro grupos. CONCLUSÃO: A associação de sulfato de magnésio e pregabalina causa boa analgesia de mastectomia com linfadenectomia axilar na primeira hora do pós-operatório. No entanto, o uso isolado do sulfato de magnésio não trouxe benefício para analgesia nestas pacientes, assim como a pregabalina sozinha se mostrou pouco efetiva na primeira hora de avaliação.

ABSTRACT BACKGROUND AND OBJECTIVES: Mastectomy with lymphadenectomy is a surgery associated with moderate to severe pain in the immediate postoperatory. Several safe adjuvant drugs that provide good analgesia with few adverse effects have been researched. Pregabalin and magnesium sulfate are drugs that promote analgesia with few adverse effects. The objective of the present study was to evaluate the analgesic effect of pregabalin and magnesium sulfate in the postoperatory of mastectomy with axillary lymphadenectomy. METHODS: Double-blinded, randomized study involving 80 patients submitted to mastectomy with axillary lymphadenectomy under general anesthesia. The patients were distributed into 4 groups: Control (CG, did not receive the proposed adjuvant drug); Magnesium+Placebo (MG, received magnesium sulfate during anesthesia); Pregabalin+Magnesium (P+MG, received magnesium added to pregabalin 150 mg before and 12 h after surgery); and Pregabalin+Placebo (PG, received pregabalin). All patients completed the Self-Report Questionnaire 20 (SRQ-20) to screen for possible mental disorders and had their physical status monitored at 1 h, 12 h, and 24 h after surgery, through anamnesis, pain questionnaire, opioid consumption, and presence of complications and/or adverse events such as nausea, vomiting, and sleepiness. Randomization was performed using sealed opaque envelopes without the knowledge of the anesthesiologist (researcher) and the patient. RESULTS: For each group, twenty patients were randomized, which were analyzed at the end of the study. The number of patients presenting absent/mild pain in P+MG was significantly higher than in CG, MG and PG after one hour. After 12 hours, P+MG and PG had more patients with absent/mild pain than CG and MG. At 24 hours postoperatively, all patients in all evaluated groups had no moderate/severe pain. There was no diference in the frequency of patients presenting nausea or vomiting, nor in the scores of the sleep evaluation after surgery in the four groups. CONCLUSION: The combination of magnesium sulfate and pregabalin provided satisfactory analgesia in the first hour after mastectomy with axillary lymphadenectomy. Nevertheless, magnesium sulfate isolated presented no analgesic beneft for the patients, and pregabalin isolated was only slightly effective at the first hour after surgery.

Abstract Background: The observation that 2-deoxy-2[18F]fluoro-D-glucose-positron emission tomography/magnetic resonance imaging ([18F]F-FDG-PET/MRI) revealed high-grade arterial wall FDG uptake, without arterial wall thickening with contrast-enhancement, in a considerable number of c-TA patients in our previous study, encouraged us to compare patients with both PET and MR angiography (MRA) positives, with those with PET positive but MRA negative. Our aim was to evaluate the relevance of these two imaging modalities together. Methods: A three-center cross-sectional study with 17 patients who fulfilled the EULAR/PRINTO/PReS criteria for c-TA and who underwent [18F]F-FDG-PET/MRI was previously performed. Herein we compared patients/vessels with positive PET (arterial wall 18F-FDG uptake higher than liver) and positive MRA (arterial wall thickening with contrast-enhancement)—group 1, with those with positive PET but negative MRA—group 2. Results: Median disease duration of 17 c-TA patients was 10.4 years. Nine patients were classified as group 1 and six as group 2. Median of metabolic inflammatory volume (MIV) of all arterial segments was significantly higher in group 1 (2346 vs. 1177 cm3; p = 0.036). Fifty-four (19%) from 284 available arterial segments presented positive findings in vessel wall in one or both images. Positive findings were concordant between PET and MRA in only 13% arterial segments (group 1); most changes (28–59.6%) that were discordant between both images, were positive in PET and negative in MRA (group 2). Conclusions: Our study demonstrated that [18F]F-FDG-PET/MRI added information about inflammation in vessel wall of c-TA patients. Prospective multicenter studies are needed in order to get solid data to guide immunosuppressive tapering and withdrawal.

RESUMO Os eventos fenológicos, em particular, a fenologia da floração e os aspectos da biologia floral ajudam a compreender a relação das plantas com seus polinizares. Assim, essa pesquisa buscou estimar, em condição semiárida, a relação entres diferentes genótipos de abóbora (Cucurbita moschata Duch.) e o ambiente, sob os aspectos da biologia reprodutiva. Quatro cultivares foram avaliados em três ciclos produtivo, mensurando as variáveis emissão diária de flores, receptividade do estigma, o tempo de antese e a morfometria das flores pistiladas e estaminadas. A emissão de flores masculinas foi superior as flores femininas com maior proporção no terceiro ciclo produtivo caracterizado por maior temperatura do ar e menor umidade relativa. Entre cultivares o ´Jacarezinho` e ´Sergipe` apresentaram a maior e a menor emissão, respectivamente. As flores femininas permanecem abertas em maior tempo em relação as flores masculinas e os estigmas permaneceram receptivos até o fechamento das flores. Considerando os dados morfométricos, há associação positiva entre o cumprimento da pétala e o diâmetro da corola e entre o acesso ao néctar e o tamanho da antera, com diferença entre os cultivares e as condições de cultivo.

ABSTRACT Phenological events, in particular, flowering phenology and aspects of floral biology help to understand the relationship of plants with their pollinators. Thus, this study sought to estimate, under semi-arid conditions, the relationship between different genotypes of pumpkin or winter squash (Cucurbita moschata Duch.) and the environment, under the aspects of reproductive biology. Four cultivars were evaluated in three productive cycles, measuring the variables daily flower emergence, stigma receptivity, anthesis time and the morphometry of pistil and staminate flowers. The production of male flowers was higher than female flowers with a higher proportion in the third production cycle characterized by higher air temperature and lower relative humidity. Among cultivars, ‘Jacarezinho’ and ‘Sergipe’ presented the highest and the lowest values of flower production, respectively. Female flowers remain open longer than male flowers and stigmas remain receptive until the flowers close. Considering the morphometric data, there is positive association between the petal length and the corolla diameter, and between access to the nectar and the anther size, with a difference between cultivars and cultivation conditions.

O capitalismo contemporâneo tem ampliado sua condição produtora de desigualdades. Este aprofundamento tem sido revelado por meio do caráter multidimensional tomado pela crise capitalista. A continuidade da crise capitalista também desafia as noções ligadas às possibilidades de correção do capitalismo e a superação das desigualdades inerentes ao modo de produção pela figura histórica da reforma. Este artigo objetiva evidenciar processos específicos, mas globais, assinalando suas “impossibilidades sistêmicas”, que apontam criticamente para as falácias do desenvolvimento, em projetos que aprofundam as disparidades sociais de toda ordem, ao serviço do grande capital e em detrimento dos trabalhadores. Isso é feito com a exposição de dois estudos de caso, Brasil e China, evidenciando o caráter multidimensional da crise capitalista e sua relação com a produção de desigualdades.

Contemporary capitalism has amplified its inequality-producing condition. Such broadening has been revealed by the multidimensional character taken by the capitalist crisis. Its continuity also challenges the notions linked to the possibilities of correcting capitalism and overcoming its intrinsic inequalities via the historical figure of reform. This paper highlights specific yet global processes, pointing out their “systemic impossibilities,” which critically unveil the fallacies of development, in projects that deepen social disparities of all kinds, at the service of big capital and to the detriment of workers. To this end, the texts analyzes two case studies – Brazil and China – highlighting the multidimensional character of the capitalist crisis and its relation to the production of inequalities.

Le capitalisme contemporain a amplifié sa condition de producteur d’inégalités. Cet élargissement a été révélé par le caractère multidimensionnel pris par la crise capitaliste. Sa continuité remet également en question les notions liées aux possibilités de corriger le capitalisme et de surmonter ses inégalités intrinsèques par le biais de la réforme. Cet essai met en lumière des processus spécifiques mais globaux, en soulignant leurs « impossibilités systématiques », qui dévoilent de manière critique les sophismes du développement, dans des projets qui approfondissent les disparités sociales de toutes sortes, au service du grand capitalisme et au détriment des ouvriers. Pour cela, le texte analyse deux études de cas – le Brésil et la Chine – mettant en évidence le caractère multidimensionnel de la crise capitaliste et sa relation avec la production d’inégalités.

The growing process of a spinel-like oxide film can be obtained through different atmospheres; in this sense Air, O2, steam, and nitrogen atmospheres were used in different steps during the aging heat treatment at 490ºC of maraging 300 and 350 alloys. The oxidation layer produced under different atmospheres was chemically, microstructurally and mechanically characterized by means of advanced techniques. The results showed (in both alloys) a non-homogeneous mix oxide formed by magnetite, nickel and cobalt ferrites and MoO3 heterogeneously distributed along the oxide thickness. It was also founded TiO2 in the innermost areas and a particularly important quantify of hematite on the external surface. A nickel-rich austenite phase was produced at the interphase due to the combination of nickel stability and the preference of cobalt, molybdenum, and iron diffuses through the film as ions. The highest thickness values were found in the oxides produced in maraging 300 steels which could indicate greater susceptibility to oxidation comparing with grade 350 maraging steel. The oxide films produced in both maraging alloys using air atmosphere presents excellent adherence, and the results show the capability for being used for tribological applications under sliding contact tests.

Resumo O objetivo geral da pesquisa foi discutir como os desastres naturais identificados no Estado do Ceará se relacionam com a variabilidade climática, destacando-se aqueles associados à precipitação, no período de 1991 a 2019. No que alude à metodologia, adotou-se pesquisa descritiva, explicativa e de natureza qualitativa-quantitativa. Tratou-se de um estudo de caso, cuja técnica de coletas de dados partiu de pesquisa documental e bibliográfica. A análise de dados foi feita a partir da estatística multivariada, por meio de regressão não-linear e coeficiente de correlação de Pearson. Os dados climáticos foram obtidos, principalmente, a partir da Fundação Cearense de Meteorologia e Recursos Hídricos (FUNCEME), já os registros de desastres, através da Coordenadoria Estadual de Defesa Civil do Ceará (CEDEC-CE) e Universidade Federal de Santa Catarina (UFSC). Os resultados obtidos mostraram que os desastres naturais com maior número de registros foram as estiagens e secas, correlacionando-se de forma alta e negativa com as chuvas, associando-se ao fenômeno El Niño e/ou às condições oceano-atmosféricas desfavoráveis às chuvas do Atlântico tropical. Já as inundações, as enxurradas, os alagamentos e as chuvas intensas constituíram o segundo grupo de tipificações de desastres examinados, correlacionando-se de forma moderada e positiva com as chuvas, associando-se ao fenômeno La Niña e/ou às condições oceano-atmosféricas favoráveis às chuvas do Atlântico tropical. Logo, concluiu-se que há uma tendência de aumento do número de desastres naturais no Ceará, os quais estão relacionados com a variabilidade climática.

Abstract The general objective of the research was to discuss how the natural disasters identified in the State of Ceará are related to climatic variability, highlighting those associated with precipitation, in the period from 1991 to 2019. Regarding the methodology, descriptive research was adopted, explanatory and qualitative-quantitative in nature. It was a case study, whose data collection technique started from documentary and bibliographic research. Data analysis was performed using multivariate statistics, using non-linear regression and Pearson's correlation coefficient. The climatic data were obtained, mainly, from the Cearense Foundation of Meteorology and Water Resources (FUNCEME), already the records of disasters, through the State Coordination of Civil Defense of Ceará (CEDEC-CE) and the Federal University of Santa Catarina (UFSC). The results obtained showed that the natural disasters with the greatest number of records were droughts and droughts, correlating highly and negatively with the rains, being associated with the El Niño phenomenon and / or the ocean-atmospheric conditions unfavorable to the rains of the Tropical Atlantic. Floods, floods, floods and heavy rains were the second group of types of disasters examined, correlating moderately and positively with rainfall, associating with the La Niña phenomenon and / or ocean-atmospheric conditions. favorable to tropical Atlantic rains. Therefore, it was concluded that there is a tendency to increase the number of natural disasters in Ceará, which are related to climatic variability.

Resumo Este estudo teve como objetivo fazer uso da Modelagem de Equações Estruturais – MEE, para avaliar a qualidade do modelo empregado pela Universidade Estadual do Ceará (UECE), no processo de seleção de seus vestibulandos, o qual é baseado na Teoria Clássica dos Testes (TCT), assim como propor ajuste a esse modelo pelo uso da Análise Fatorial de Segunda Ordem e da Análise de Regressão, via MEE. Utilizou-se um banco de dados composto dos resultados das provas de 11.060 candidatos ao vestibular de 2018.1, cujo tratamento se deu por meio do software IBM SPSS Amos (2013, v.22), obtendo-se os seguintes indicadores de qualidade: CFI ( Comparative Fit Index ) = 0,925; GFI ( Goodness-of-fit Index ) = 0,965; TLI ( Tucker Lewis Index ) = 0,922, e RMSEA ( Root Mean Square Error of Aproximation ) = 0,019. Juntos, esses indicadores demonstraram que o modelo é robusto e bastante consistente, apresentando um R 2 (Coeficiente de Correlação de Pearson ) = 0,965, indicando que a proporção das covariâncias observadas entre as variáveis manifestas e explicada pelo modelo ajustado é bastante significativa. Todas as variáveis do modelo ajustado apresentaram elevados coeficientes de regressão com valores entre 0,87 e 0,99, permitindo uma boa discriminação entre as notas dos vestibulandos, principalmente aqueles com o mesmo número de questões respondidas corretamente.

Abstract The objective of this study is to make use of Structural Equation Modeling (SEM) in evaluating the model employed by the State University of Ceará (Uece) in the selection process of prospective students, which is based on the Classical Test Theory (CCT), as well as to propose adjustments to this model through the use of Second Order Factor Analysis and Regression Analysis, via MME. The data set used is comprised of results of 11,060 admission exams from the year 2018.1. AMOS/SPSS-v.22 software was used to process the data, obtaining the following quality indicators: CFI (Comparative Fit Index) = 0.925; GFI (Goodness-of-fit Index) = 0.965; TLI (Tucker Lewis Index) = 0.922, and RMSEA (Root Mean Square Error of Approximation) = 0.019. Together, these indicators demonstrate that the model is robust and highly consistent, presenting a R2 (Pearson Correlation Coefficient) = 0.965, indicating that the proportion of covariates, observed among the manifest variables and explained by the adjusted model, is very significant. All the variables of the adjusted model present elevated regression coefficients with values between 0.874 e 0.996, allowing for good discrimination between applicant scores, especially for those with the same number of correct question responses.

Resumen Este estudio tuvo como objetivo hacer uso del Modelo de Ecuación Estructural - MEE, para evaluar la calidad del modelo utilizado por la Universidad Estatal de Ceará (Uece), en el proceso de selección de sus exámenes de ingreso, el cual se basa en la Teoría Clásica de Pruebas (TCT), además de proponer el ajuste a este modelo mediante el uso de Análisis Factorial de Segundo Orden y Análisis de Regresión, vía MEE. Se utilizó una base de datos compuesta por los resultados de las pruebas de 11.060 candidatos a la prueba de ingreso 2018, la cual fue procesada utilizando el software AMOS/SPSS-v.22, obteniendo los siguientes indicadores de calidad: CFI (Comparative Fit Index) = 0,925; GFI (Goodness-of-fit Index) = 0,965; TLI (Tucker Lewis Index) = 0,922 y RMSEA (Root Mean Square Error of Aproximation) = 0,019. Juntos, estos indicadores demostraron que el modelo es robusto y bastante consistente, presentando un R2 (Coeficiente de Correlación de Pearson) = 0.965 indicando que la proporción de covarianza observada entre las variables manifestadas y explicada por el modelo ajustado es bastante significativa. Todas las variables del modelo ajustado mostraron altos coeficientes de regresión con valores entre 0,87 y 0,99, lo que permitió una buena discriminación entre las calificaciones de los estudiantes, especialmente aquellos con el mismo número de preguntas respondidas correctamente.

Resumo A despeito do atual período de ascensão conservadora e plena crise sanitária, política, social, cultural e econômica que assola o continente sul-americano, o Mercado Comum do Sul (Mercosul) completou trinta anos, consolidando-se como bloco regional. Contudo, desarticulado e sob risco de perder os avanços conquistados, o bloco ainda não definiu os rumos para a recuperação ou recriação de uma agenda ampla como a integração do início do século XXI. Este artigo enfatiza a trajetória singular da integração sul-americana a partir de seu caráter original de região periférica do capitalismo e sugere que a conexão entre autonomia, intergovernabilidade e democracia é condição teórica para compreensão. Consideramos a experiência integracionista do sul na agenda progressista de 2005 a 2015, pois esta oferece subsídios para a análise, e refletimos sobre os efeitos do ascenso da aproximação chinesa no continente, em franca disputa com os Estados Unidos.

Abstract Despite the current period of conservatism rise and the political, social, cultural, economic, and health crisis that devastates the American continent, the el Mercado Común del Sur (Mercosur) has completed 30 years, consolidating itself as a regional bloc. However, disarticulated and at risk of losing its achievements, the Mercosur has not yet defined the paths for the recovery or re-creation of a broad agenda, such as occurred in the beginning of the 21st century. This article emphasizes the singular trajectory of South American integration from its original character as a peripheral region of capitalism, suggesting that the connection between autonomy, intergovernability, and democracy is a theoretical condition for its understanding. Based on the integrationist experience of the South in the 2005-2015 progressive agenda, we will discuss the effects of the rise of Chinese rapprochement on the continent in open dispute with the United States.

Resumo Fornecer bancos de dados confiáveis sobre a biodiversidade é importante, pois são a matéria-prima para estudos complexos em ecologia, biogeografia e conservação. A região de Londrina, estado do Paraná, sul do Brasil, teve sua fauna estudada desde 1982, por um grupo de pesquisadores do Laboratório de Ecologia de Mamíferos da Universidade Estadual de Londrina, resultando em um extenso volume de dados sobre a diversidade de morcegos, muitos dos quais ainda não foram publicados. Aqui, compilamos e revisamos toda a literatura e dados não publicados e fornecemos um banco de dados com informações sobre riqueza, distribuição e lacunas de amostragem. Nossa compilação resultou em uma lista de 41 espécies para Londrina, 14 espécies a mais do que as indicadas para a região no banco de dados atual para morcegos da Mata Atlântica. Um total de 29 espécies foram registrado em Áreas Protegidas (Parque Estadual Mata dos Godoy e Parque Municipal Arthur Thomas), além de outros locais. Apesar do longo tempo de amostragem, constatamos que a região ainda carece de informações sobre a fauna de morcegos para a maioria de seus remanescentes florestais, principalmente na região norte. O fragmento florestal com maior número de noites de amostragem, o Parque Estadual Mata dos Godoy, ainda está subamostrado. Nosso banco de dados pode servir como base para estudos de ecologia e conservação e para determinar áreas prioritárias para futuros esforços de amostragem, usando diversos métodos de captura de morcegos.

Abstract Providing reliable databases on biodiversity is important, as they are the raw material for complex studies in ecology, biogeography and conservation. The region of Londrina, Paraná state, southern Brazil, has had its bat fauna studied since 1982, by a group of researchers from the Laboratório de Ecologia de Mamíferos, Universidade Estadual de Londrina, resulting in an extensive amount of data on the diversity of bats, many of which have yet to be published. Here, we compiled and reviewed all of the literature and unpublished data and provide a database with information on richness, distribution and sampling gaps. Our compilation resulted in a list of 41 species for Londrina, 14 more species than indicated for the region in the current database “Atlantic Forest bats”. A total of 29 species were recorded within Protected Areas (Parque Estadual Mata dos Godoy and Parque Municipal Arthur Thomas), in addition to other sites. Despite the long sampling time, we found that the region still lacks information on bat fauna for most of its forest remnants, especially in the northern region. The forest fragment with the greatest number of sampling nights, the Parque Estadual Mata dos Godoy, is still under-sampled. Our database can serve as a basis for ecological and conservation studies and to determine priority areas for future sampling efforts, using a diversity of bat sampling methods.

ABSTRACT Chimeric antigen receptor T (CAR-T) cell therapy is a novel therapeutic modality for acute lymphoblastic leukemia (ALL) with robust outcomes in patients with refractory or relapsed disease. At the same time, CAR-T cell therapy is associated with unique and potentially fatal toxicities, such as cytokine release syndrome (CRS) and neurological toxicities (ICANS). This manuscript aims to provide a consensus of specialists in the fields of Hema- tology Oncology and Cellular Therapy to make recommendations on the current scenario of the use of CAR-T cells in patients with ALL.

ABSTRACT Chimeric antigen receptor T-cells (CAR-T cells) are a new modality of oncological treatment which has demonstrated impressive response in refractory or relapsed diseases, such as acute lymphoblastic leukemia (ALL), lymphomas, and myeloma but is also associated with unique and potentially life-threatening toxicities. The most common adverse events (AEs) include cytokine release syndrome (CRS), neurological toxicities, such as the immune effector cell-associated neurotoxicity syndrome (ICANS), cytopenias, infections, and hypogammaglobulinemia. These may be severe and require admission of the patient to an intensive care unit. However, these AEs are manageable when recognized early and treated by a duly trained team. The objective of this article is to report a consensus compiled by specialists in the fields of oncohematology, bone marrow transplantation, and cellular therapy describing recommendations on the Clinical Centers preparation, training of teams that will use CAR-T cells, and leading clinical questions as to their use and the management of potential complications.

ABSTRACT The treatment and evolution of B-cell non-Hodgkin lymphoma (B-NHL) has undergone important changes in the last years with the emergence of targeted therapies, such as monoclonal antibodies, small molecules, antibody-drug conjugates, and bispecific antibodies. Nevertheless, a significant portion of patients remains refractory or relapsed (R/R) to the new therapeutic modalities, representing thus an unmet medical need. The use of CAR-T cells for the treatment of B-NHL patients has shown to be a promising therapy with impressive results in patients with R/R disease. The expectations are as high as the imminent approval of CAR-T cell therapy in Brazil, which it is expected to impact the prognosis of R/R B-NHL. The aim of this manuscript is to offer a consensus of specialists in the field of onco-hematology and cellular therapy, working in Brazil and United States, in order to discuss and offer recommendations in the present setting of the use of CAR-T cells for patients with B-NHL.