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Exploration of the mechanism underlying the therapeutic effect of electroacupuncture at chengshan acupoint on post-hemorrhoidectomy anal pain: Insights from the mAChRs/IP3-Ca2+-CaM signaling pathway
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Song, Yang

; Wang, Yang Li, Ming Wang, Yujuan Xu, Tianshu

Clinics

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2024, Volume 79 elocation 100485

Abstract: En | Text: En | PDF: En

Abstract Objective In the context of postoperative anal pain, understanding the intricate mechanisms and effective interventions is paramount. This study investigates the role of Muscarinic Acetylcholine Receptors (mAChRs) and the IP3-Ca2+-CaM signaling pathway in a rat model of postoperative anal pain, exploring the potential analgesic effects of electroacupuncture. Methods Comprehensive approaches involving mechanical sensitivity assays, Western blotting, immunohistochemistry, and intracellular calcium concentration measurement were used. Results The authors found elevated mAChRs expression in the postoperative pain model. Antagonizing mAChRs reduced pain sensitivity and attenuated the IP3-Ca2+-CaM pathway. Remarkably, electroacupuncture treatment further mitigated pain, potentially by suppressing this signaling cascade. Interpretation These findings reveal a novel connection between mAChRs and the IP3-Ca2+-CaM pathway in postoperative anal pain and suggest electroacupuncture as a promising avenue for pain relief through these mechanisms, offering insights into innovative strategies for postoperative pain management.

https://doi.org/10.1016/j.clinsp.2024.100485

Analytical and experimental study on elliptical cross-section double-ogive-nose projectile penetration into plain concrete target
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Dai, Xianghui

; Wang, Kehui

; Zhou, Gang

; Shen, Zikai

; Ke, Ming

; Li, Ming

Latin American Journal of Solids and Structures

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2024, Volume 21 N. 2 elocation e527

Abstract: En | Text: En | PDF: En

Abstract A general geometric model of the elliptical cross-section double-ogive-nose projectile (ECDP) was established, and the expression of penetration resistance was obtained. Based on the special shape and penetration process characteristics of the ECDP, a three-stage penetration model was constructed, and closed-form penetration equations were derived. Three ECDPs with the major–minor axis ratio of 1.5 were launched by a 130 mm gas-gun to impact the plain concrete targets with the oblique angle of 10° at a nominal striking velocity of 650 m/s, the experimental data such as the penetration depth of the ECDPs and the failure characteristic parameter of the targets was obtained. The initial posture of the ECDP had little effect on the penetration depth and trajectory deflection under the condition of the target with 10° oblique angle, but it had obvious influence on the structural response. The theoretical model was verified by experimental data, the calculated result of the penetration depth was in good agreement with the experimental data, the deviation was within the range of -13.5% ~ -8.5%.

https://doi.org/10.1590/1679-78257753

The effects of sheet dimension on the 3D curved parts rolling based on arc-shaped rollers
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Xiang, Chang

; Li, Ming

; Sun, Depeng

; Chen, Chuandong

Matéria (Rio de Janeiro)

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2024, Volume 29 N. 4 elocation e20240534

Abstract: En | Text: En | PDF: En

ABSTRACT The rolling of 3D curved parts based on arc-shaped rollers is a new and effective method for forming curved parts with double curvature. In this paper, the spherical parts are taken as an example, and the influence of sheet dimension on the rolling of 3D curved parts is studied for the first time. A series of numerical simulations and experiments are carried out with different sheet dimensions under the same maximum rolling reduction ratio. The effect of the length, width, and thickness of the sheet metal on the longitudinal bending deformation and material utilization of the formed spherical parts was investigated. Numerical simulation and experimental results show that the longitudinal bending deformation of the formed spherical part is not affected by the sheet length, and decreases with the increase of the sheet width, and decreases with the increase of the sheet thickness. The material utilization rate of the formed spherical part increases with the increase of the sheet length, decreases with the increase of the sheet width, and decreases with the increase of the sheet thickness.

https://doi.org/10.1590/1517-7076-rmat-2024-0534

The Role of MMP-9 in Regulating Degradation of the Splenic Microvascular Basement Membrane Induced by High Altitude Hypoxia
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Ma, Yi Zhu, Li-Ming Liu, Wen-Ling Yin, Yu-Juan Peng, Xiao Chun Zhu, Ming-Ming

International Journal of Morphology

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aug 2023, Volume 41 N. 4 Pages 1152 - 1157

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

SUMMARY: To investigate changes of MMP-9 in the rat spleen and hypoxia-induced microvascular basement membrane under high altitude hypoxia. Thirty male specific pathogen-free Sprague Dawley rats were randomly divided into control and hypoxia groups, with 15 rats in each group. The rats in the control group were placed in Dingxi City, Gansu Province (2080 m above sea level) for 30 days. Rats in the hypoxia group were raised in a hypoxic environment in Maduo County, Qinghai Province (4300 m above sea level), for 30 days to establish a hypoxic rat model. Routine blood tests, MMP-9 mRNA, MMP-9 protein, and the spleen microvascular basement membrane were detected. (1) Compared with the control group, the red blood cell count, hemoglobin, and hematocrit levels of the rats in the hypoxia group were all increased; thus, a hypoxia model was successfully established. (2) Compared with the control group, the expression of MMP-9 mRNA and protein was significantly higher in the spleen of rats in the hypoxic group, and the difference was statistically significant (P <0.05). (3) Compared with the control group, the blood vessel basement membrane in the spleen of the hypoxia group was degraded. Under natural low air pressure and high altitude conditions, the expression of MMP-9 in rat spleen tissue increases and participates in the degradation of the microvascular basement membrane.

RESUMEN: El objetivo de este trabajo fue investigar los cambios de la MMP-9 en el bazo de la rata y la membrana basal microvascular inducida bajo hipoxia a gran altura. Treinta ratas macho Sprague Dawley, libres de patógenos específicos, se dividieron aleatoriamente en dos grupos de 15 ratas cada uno, un grupo control y un grupo hipoxia. Durante 30 días las ratas del grupo control estuvieron en la ciudad de Dingxi, provincia de Gansu (2080 m sobre el nivel del mar). Las ratas del grupo de hipoxia se criaron en un entorno hipóxico en el condado de Maduo, provincia de Qinghai (4300 m sobre el nivel del mar), durante 30 días para establecer un modelo de rata hipóxica. Se realizaron análisis de sangre de rutina, ARNm de MMP-9, proteína MMP-9 y de la membrana basal microvascular del bazo. En comparación con el grupo control, el recuento de glóbulos rojos, la hemoglobina y los niveles de hematocrito de las ratas del grupo de hipoxia aumentaron; por lo tanto, se estableció con éxito un modelo de hipoxia. En comparación con el grupo control, la expresión de ARNm y proteína de MMP-9 fue significativamente mayor en el bazo de las ratas del grupo hipóxico, siendo la diferencia estadísticamente significativa (P <0,05). En comparación con el grupo control, la membrana basal de los vasos sanguíneos estaba degradada en el bazo del grupo hipoxia. En condiciones naturales de baja presión atmosférica y gran altitud, la expresión de MMP-9 en el tejido del bazo de la rata aumenta y participa en la degradación de la membrana basal microvascular.

Prediction of IDH1 gene mutation by a nomogram based on multiparametric and multiregional MR images
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Zheng, Jinjing

; Dong, Haibo Li, Ming Lin, Xueyao Wang, Chaochao

Clinics

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2023, Volume 78 elocation 100238

Abstract: En | Text: En | PDF: En

Abstract Objective To investigate the value of a nomogram based on multiparametric and multiregional MR images to predict Isocitrate Dehydrogenase-1 (IDH1) gene mutations in glioma. Data and methods The authors performed a retrospective analysis of 110 MR images of surgically confirmed pathological gliomas; 33 patients with IDH1 gene Mutation (IDH1-M) and 77 patients with Wild-type IDH1 (IDH1-W) were divided into training and validation sets in a 7:3 ratio. The clinical features were statistically analyzed using SPSS and R software. Three glioma regions (rCET, rE, rNEC) were outlined using ITK-SNAP software and projected to four conventional sequences (T1, T2, Flair, T1C) for feature extraction using AI-Kit software. The extracted features were screened using R software. A logistic regression model was established, and a nomogram was generated using the selected clinical features. Eight models were developed based on different sequences and ROIs, and Receiver Operating Characteristic (ROC) curves were used to evaluate the predictive efficacy. Decision curve analysis was performed to assess the clinical usefulness. Results Age was selected with Radscore to construct the nomogram. The Model 1 AUC values based on four sequences and three ROIs were the highest in these models, at 0.93 and 0.89, respectively. Decision curve analysis indicated that the net benefit of model 1 was higher than that of the other models for most Pt-values. Conclusion A nomogram based on multiparametric and multiregional MR images can predict the mutation status of the IDH1 gene accurately.

https://doi.org/10.1016/j.clinsp.2023.100238

Electroacupuncture inhibits dendritic spine remodeling through the srGAP3-Rac1 signaling pathway in rats with SNL
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Wu, Qiaoyun

; Cai, Chenchen Ying, Xinwang Zheng, Yujun Yu, Jiaying Gu, Xiaoxue Tu, Wenzhan Lou, Xinfa Yang, Guanhu Li, Ming Jiang, Songhe

Biological Research

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2023, Volume 56 elocation 26

Abstract: En | Text: En | PDF: En

Abstract Previous studies have shown that peripheral nerve injury can lead to abnormal dendritic spine remodeling in spinal dorsal horn neurons. Inhibition of abnormal dendritic spine remodeling can relieve neuropathic pain. Electroacupuncture (EA) has a beneficial effect on the treatment of neuropathic pain, but the specific mechanism remains unclear. Evidence has shown that slit-robo GTPase activating protein 3 (srGAP3) and Rho GTPase (Rac1) play very important roles in dendritic spine remodeling. Here, we used srGAP3 siRNA and Rac1 activator CN04 to confirm the relationship between SrGAP3 and Rac1 and their roles in improving neuropathic pain with EA. Spinal nerve ligation (SNL) was used as the experimental model, and thermal withdrawal latency (TWL), mechanical withdrawal threshold (MWT), Western blotting, immunohistochemistry and Golgi-Cox staining were used to examine changes in behavioral performance, protein expression and dendritic spines. More dendritic spines and higher expression levels of srGAP3 were found in the initial phase of neuropathic pain. During the maintenance phase, dendritic spines were more mature, which was consistent with lower expression levels of srGAP3 and higher expression levels of Rac1-GTP. EA during the maintenance phase reduced the density and maturity of dendritic spines of rats with SNL, increased the levels of srGAP3 and reduced the levels of Rac1-GTP, while srGAP3 siRNA and CN04 reversed the therapeutic effects of EA. These results suggest that dendritic spines have different manifestations in different stages of neuropathic pain and that EA may inhibit the abnormal dendritic spine remodeling by regulating the srGAP3/Rac1 signaling pathway to alleviate neuropathic pain.

https://doi.org/10.1186/s40659-023-00439-0

Variation of Plantaris Muscle: A Case Report with Clinical Significance
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Chen, Hui-Guang Xue, Pei-Ran Wang, Cheng-Tao Liu, Xiao-Liu Li, Ming-Zhe

International Journal of Morphology

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jun 2022, Volume 40 N. 3 Pages 851 - 854

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

SUMMARY: The plantaris muscle is located between the soleus and gastrocnemius muscles, within the posterior calf group. Due to degeneration and its loss of plantar-flexion function, the muscle is vestigial in human beings, but it retains clinical significance. Few cases of variation in the plantaris muscle have been reported, and this, therefore, appears to be rare. Nonetheless, absence of this muscle was identified via the dissection of a left lower limb (male), which also indicated the absence of an attachment in the usual position. The present report, which addresses such variation, may provide both inspiration and reference points for the clinical treatment of so-called “tennis leg”, and for the use of plantaris muscle for the purposes of clinical, autologous graft repair.

RESUMEN: El músculo plantar se ubica entre los músculos sóleo y gastrocnemio, dentro del grupo posterior de la pierna. Debido a la degeneración y la pérdida de la función de flexión plantar, el músculo es un vestigio en los seres humanos, pero conserva su importancia clínica. Se han informado pocos casos de variación en el músculo plantar y, por lo tanto, esto parece ser raro. No obstante, se observó la ausencia de este músculo durante la disección de un miembro inferior izquierdo (masculino). El presente informe, que aborda dicha variación, puede proporcionar puntos de referencia para el tratamiento clínico de la llamada "pierna de tenista" y para el uso del músculo plantar con fines de reparación clínica con injerto autólogo.

Imaging features and clinic value of mri and ct in diagnosis of clear cell renal cell carcinoma
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YANG, Zhongjie

; LI, Ming GUO, Aiju LIANG, Yonghui FANG, Peng

Food Science and Technology

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2022, Volume 42 elocation e40520

Abstract: En | Text: En | PDF: En

Abstract To investigate the imaging features and clinic value of magnetic resonance imaging (MRI) and computed tomography (CT) in the diagnosis of clear cell renal cell carcinoma (ccRCC). 139 RCC patients underwent MRI and CT examination before surgery, and the sensitivity, specificity, accuracy, positive and negative predictive values of MRI and CT in diagnosing ccRCC were analyzed and compared. There were 93 true-positive, 11 false-positive, 11 false-negative and 24 true-negative in MRI screening with sensitivity, specificity, accuracy, positive predictive value and negative predictive value of 89.42%, 68.57%, 84.17%, 89.42% and 68.57% respectively. Whereas there were 72 true-positive, 4 false-positive, 32 false-negative and 31 true-negative in CT screening with the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of 69.23%, 88.57%, 74.10%, 94.74% and 49.21% respectively. The sensitivity and negative predictive value of MRI were better than those of CT, while the specificity of CT was better than that of MRI. MRI and CT have respective advantages in the diagnosis of ccRCC. The sensitivity and negative predictive value of MRI are superior to those of CT, while the specificity of CT is superior to that of MRI. Clinically, different examinations are selected according to different situations.

https://doi.org/10.1590/fst.40520

IPO7 promotes pancreatic cancer progression via regulating ERBB pathway
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Li, Ming

; Xu, Dongqiang Zhan, Yijun Tan, Shiyun

Clinics

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2022, Volume 77 elocation 100044

Abstract: En | Text: En | PDF: En

Abstract Background Importin 7 (IPO7) belongs to the Importin β family and is implicated in the progression of diverse human malignancies. This work is performed to probe the role of IPO7 in pancreatic cancer development and its potential downstream mechanisms. Methods IPO7 expression in PC and paracancerous tissues were measured using Immunohistochemistry (IHC) staining and qRT-PCR. Western blotting was utilized to detect the expression level of IPO7 in PC cells and immortalize the pancreatic ductal epithelial cell line. After constructing the IPO7 overexpression and knockdown models, the effect of IPO7 on the proliferation of PC cells was analyzed by the CCK-8 and EdU assay. The migration and invasion of PC cells were examined by wound healing assay and Transwell experiment. The apoptosis rate of PC cells was analyzed by flow cytometry and TUNEL assay. The Gene Set Enrichment Analysis (GSEA) was used to determine the enrichment pathways of IPO7. The effect of IPO7 on the ERBB2 expression was determined using Western blotting. A xenograft mouse model was applied to investigate the carcinogenic effect of IPO7 in vivo. Results IPO7 expression was remarkably elevated in the cancer tissues of PC patients. IPO7 overexpression remarkably enhanced PC cell proliferation, migration and invasion and suppressed apoptosis, while knockdown of IPO7 exerted the opposite effect. Mechanistically, IPO7 facilitated the malignant phenotype of PC cells by up-regulating ERBB2 expression. In addition, knockdown of IPO7 inhibited tumor growth and lung metastasis in vivo. Conclusion IPO7 can act as an oncogenic factor and accelerate PC progression by modulating the ERBB pathway.

https://doi.org/10.1016/j.clinsp.2022.100044

10.

Study on mechanism of coix seed oil intervening hepatic fibrosis in immune injury rats
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WANG, Bao-Quan

; MENG, Tao PING, Juan ZHOU, Li-Ming SHEN, Zhi-Hui SHI, Zhao-Hui ZHANG, Yong-Zhou

Food Science and Technology

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2022, Volume 42 elocation e23822

Abstract: En | Text: En | PDF: En

Abstract This study aims to investigate the effect and specific mechanism of Coix Seed Oil (CSO) on immune hepatic fibrosis in immune injury rats. In this study, healthy Wister rats were injected with porcine serum in order to establish hepatic fibrosis model. We choose the compound Sophora flavescens injection as the positive control drug. HE staining was used to observe the morphological and histological changes. HSC-T6 cells were cultured in vitro. MTT and AO/EB staining were used to detect the effect of CSO on the proliferation and apoptosis of HSC-T6 cells. The results shown that Coix seed oil significantly improved hepatic fibrosis of immune injury rats, and the degree of hepatic fibrosis in CSO group was significantly reduced. Intraperitoneal injection of 15 mg/kg, 30 mg/kg and 40 mg/kg significantly reduced the levels of serum ALT, AST, ALP, HA, LN, PIIINP and C-IV in rats (P < 0.01).), MTT assay showed that the cells proliferated well. The results of HE staining showed that Coix seed oil had a good therapeutic effect on immune-induced hepatic fibrosis in rats. AO/EB staining showed that 0.5 mg/mL CSO for 24 h and 0.1 mg/mL CSO for 48 h both significantly promoted the apoptosis of HSC-T6 cells. In conclusion, Coix seed oil has a significant therapeutic effect on immune hepatic fibrosis, and its molecular mechanism may be related to antagonizing cytokine TGF-β1, inhibiting the expression of TIMP-1, promoting collagen degradation, inhibiting the activation of hepatocyte and promoting the apoptosis of activated hepatic stellate cells.

https://doi.org/10.1590/fst.23822

11.

The effect of recombinant human interferon α1b treatment of infants hospitalized with lower respiratory tract infection on subsequent wheezing
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Yang, Lihua

; Zhang, Guocheng

; Huang, Lusheng

; Ren, Xiaoling

; Su, Yanqi

; Wang, Chengxiu

; Shi, Yuanbin

; Li, Liao

; Shan, Hui

; Chen, Jing

; Xiong, Jianxin

; Xue, Xue

; Song, Shaofeng

; Zhao, Li

; An, Shuhua

; Yu, Haiming

; Cao, Hong

; Zhao, Lin

; Li, Ming

; Sheng, Xiaocui

; Wang, Yajun

Jornal de Pediatria

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dec 2021, Volume 97 N. 6 Pages 617 - 622

Abstract: En | Text: En | PDF: En

Abstract Objective: To investigate the impact of recombinant human interferon α1b (rhIFNα1b) treatment in infants hospitalized with lower respiratory tract infections on subsequent wheezing. Methods: The clinical data of infants (n = 540) with viral pneumonia, wheezy bronchitis, or bronchiolitis hospitalized in 19 Chinese hospitals from June 2009 to June 2015 were retrospectively analyzed. The parameters relevant to wheezing episodes within the last year were collected by telephone and questionnaires. The rhIFNα1b treatment group (n = 253) and control group (n = 287) were compared in terms of wheezing episodes within the last year. Moreover, the wheezing group (95 cases) and non-wheezing group (445 cases) were compared. Results: Out of 540 cases, 95 (17.6%) experienced wheezing episodes, 13.8% (35/253) cases treated with rhIFNα1b, and 20.9% (60/287) cases without rhIFNα1b experienced wheezing episodes within the last year. The rhIFNα1b treatment significantly improved wheezing episodes within the last year, compared with the control peers (p = 0.031). Single-factor regression showed statistically significant differences between the wheezing and non-wheezing groups in terms of age, rhIFNα1b use, childhood and family history of allergy, housing situation, and feeding history (p < 0.05). Binary logistic regression showed a childhood history of allergy (OR = 2.14, p = 0.004), no rhIFNα1b use (OR = 1.70, p = 0.028), and living in a crowded house (OR = 1.92, p = 0.012) might be risk factors of subsequent wheezing. Accordingly, breastfeeding (OR = 0.44, p = 0.008) and hospitalization age of 1-year-old (OR = 0.58, p = 0.024) were protective factors. Conclusions: Early use of rhIFNα1b in infants hospitalized with lower respiratory tract infections and breastfeeding could prevent subsequent wheezing. Living in a crowded house could promote subsequent wheezing.

https://doi.org/10.1016/j.jped.2020.12.005 1 downloads

12.

PARAMETER ANALYSIS AND EXPERIMENT OF CITRUS STALK CUTTING FOR ROBOT PICKING
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Xiao, Xu

; Huang, Jingjing Li, Ming Xu, Yongwei Zhang, Hongduo

Engenharia Agrícola

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oct 2021, Volume 41 N. 5 Pages 551 - 558

Abstract: En | Text: En | PDF: En

ABSTRACT In order to provide the basis for the design and control of a citrus picking robot clamp and cutter, and find the optimal combination of cutting parameters, this study used a self-made citrus stem cutting test-bed to study the effects of the citrus stem diameter, blade cutting speed, blade cutting clearance, and tool sliding cutting angle on the peak cutting force of citrus stems through a single-factor experiment. Based on the single-factor test, the blade cutting speed, blade cutting clearance, and tool sliding angle are selected as the influencing factors, and a multi-factor test is carried out with the target of the peak cutting force, and the regression model is established. The results showed that the peak cutting force increased linearly with the diameter of the fruit stalk, decreased with the increase of the blade cutting speed and sliding cutting angle, and first decreased and then increased with the increase of the blade cutting clearance. Through the optimisation analysis of the regression model, it is found that the optimal cutting parameter combination is the blade cutting speed of 40 mm/min, blade cutting gap of 1 mm, tool sliding cutting angle of 20°, and the peak cutting force under this combination is 168.23 N. The deviation between the predicted value of the peak cutting force and the measured value is less than 2%, and the optimisation result of the cutting parameters is reliable. This study provides a theoretical basis for the optimal design and control of the clamping and cutting mechanism of the citrus picking robot.

https://doi.org/10.1590/1809-4430-eng.agric.v41n5p551-558/2021

13.

Homeobox B2 is a potential prognostic biomarker of glioblastoma
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Li, Ming

; Wang, Jiu-Fei

; Liu, Bo

; Wang, Xiao-Min

Revista da Associação Médica Brasileira

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jun 2020, Volume 66 N. 6 Pages 794 - 799

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVOS A HOXB2 é um novo indicador prognóstico para o câncer de pulmão. Mas não está claro se a HOXB2 tem algum efeito na progressão do glioblastoma (GBM). O objetivo deste artigo foi sondar as influências da HOXB2 na patogênese do GBM. MÉTODOS Foram analisados o nível de expressão e o poder prognóstico da HOXB2 em pacientes com GBM. Em seguida, os níveis de expressão proteica e mRNA da HOXB2 em linhagens de células de GBM foram testados por qRT-PCR e western blotting. A proliferação, a invasão e migração celular foram determinadas por CCK8 e ensaios transwell, várias vezes. Os níveis proteicos das proteínas associadas à via PI3K/AKT foram analisados pelo método western blotting. RESULTADOS Os resultados indicaram que havia uma clara superrexpressão da HOXB2 em pacientes com GBM e que a alta expressão da HOXB2 estava relacionada a um prognóstico negativo. Além disso, a expressão da HOXB2 foi mais elevada em todas as linhagens de células do GBM U251, U-87MG, GOS-3 do que nas células HEB (controle normal). Entretanto, a diminuição da expressão de P-PI3K e p-AKT foi identificada após a redução da expressão da HOXB2. CONCLUSÕES Esses dados demonstram que a HOXB2 desempenha um papel vital na progressão do GBM, podendo ser um alvo promissor para o tratamento do GBM.

SUMMARY OBJECTIVES HOXB2 is a new prognostic indicator for lung cancer. But it is unclear whether HOXB2 holds an effect in glioblastoma (GBM) progression. The purpose of this article was to probe the influences of HOXB2 on GBM pathogenesis. METHODS HOXB2 expression level and prognostic power in GBM patients were analyzed. Then the mRNA and protein expression levels of HOXB2 in GBM cell lines were tested by qRT-PCR and western blotting. Cell proliferation, invasion, and migration were determined by CCK8 and transwell assay, severally. The protein levels of PI3K/AKT-pathway associated proteins were analyzed by western blotting. RESULTS The results indicated that HOXB2 was distinctly overexpressed in GBM patients and high expression of HOXB2 was related to a poor prognosis. Moreover, the expression of HOXB2 was higher in all GBM cell lines U251, U-87MG, GOS-3 than that in HEB cells (normal control). Meanwhile, decreased expression of p-PI3K and p-AKT were identified after HOXB2 knockdown. CONCLUSIONS These data demonstrated that HOXB2 had a vital role in GBM progression and could serve as a promising target for GBM treatment.

https://doi.org/10.1590/1806-9282.66.6.794 595 downloads

14.

Effects of Pouring Temperature on Microstructure and Mechanical Properties of the A356 Aluminum Alloy Diecastings
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Li, Ming

; Li, Yuandong Zhou, Hongwei

Materials Research

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2020, Volume 23 N. 1 elocation e20190676

Abstract: En | Text: En | PDF: En

Abstract Diecastings of the A356 aluminum alloy were produced by rheo-diecasting (RDC) and High pressure die casting (HPDC), the microstructures of primary solidification, secondary solidification and eutectic Si of diecastings with different pouring temperature were explored and the mechanical properties of different parameters were tested. The result shows that the primary α-Al grains in RDC with self-inoculation method (SIM) are smaller and rounder than the dendrite structure in HPDC. During the RDC process, the amount of primary α-Al grains, average grain size and the lamellar spacing of the eutectic Si increase with the decrease of the melt treatment temperature. While the average grain size and the shape factor are gradually increasing with the increase of melt treatment temperature. As a result, RDC can significantly improve the mechanical properties of the A356 aluminum alloy compared with HPDC, the mechanical properties are optimal at 600°Cwith the tensile strength and elongation are 268.67MPa and 6.8%, respectively.

https://doi.org/10.1590/1980-5373-mr-2019-0676 2176 downloads

15.

Microstructural Evolution and Mechanical Properties of As-Cast Mg-12Zn Alloys with Different Al Additions
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Zhang, Yu

; Li, Ming

; Yang, Wen-Long Wang, Zong-Gang Wang, Xue-Zhi

Materials Research

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2020, Volume 23 N. 1 elocation e20190582

Abstract: En | Text: En | PDF: En

Abstract In this study, Mg-12Zn magnesium alloys alloyed with Al additions (0, 2, 4, 6, 8 and 10, wt.%) were fabricated by permanent mould casting. The Al content on their microstructure and mechanical properties were systematically examined with an optical microscope (OM), a scanning electron microscope (SEM), an X-ray diffractometer (XRD) and mechanical tests at room temperature. The experimental results indicate that the microstructure of the alloys is mainly composed of α-Mg and semi-continuous or continuous eutectic phases. A higher addition of Al (≥6%) causes the generation of the Mg17Al12 phases. Notably, the grain sizes of the alloys gradually decrease, whilst the partial morphology of some eutectic phases is modified into lamellar structure with increasing of Al addition. Mechanical properties characterization manifested that, the alloys with different Al additions reveal distinguishing tensile properties. Among them, the alloy with 4% Al provides an excellent mechanical properties, i.e., a UTS of 206 MPa and an EL of 7.92%, which is respectively higher 28 MPa and 1.08% than that of ZA120 alloy. The deterioration in the tensile properties for the higher Al-bearing alloys is possibly related to the lamellar structure, coarse and continuous net-work morphology and β-Mg17Al12 phases, respectively.

https://doi.org/10.1590/1980-5373-mr-2019-0582 762 downloads

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