Abstract The genus Candida represents the main cause of infections of fungal origin. Some species stand out as disease promoters in humans, such as C. albicans, C. glabrata, C. parapsilosis, and C. tropicalis. This study evaluated the antifungal effects of propyl (E)-3-(furan-2-yl) acrylate. The minimum inhibitory concentration of the synthetic compound, amphotericin B and fluconazole alone against four species of Candida ranged from 64 to 512 μg/mL, 1 to 2 μg/mL, and 32 to 256 μg/mL, respectively. The synergistic effect of the test substance was observed when associated with fluconazole against C. glabrata, there was no antagonism between the substances against any of the tested strains. The potential drug promoted morphological changes in C. albicans, decreasing the amount of resistance, virulence, and reproduction structures, such as the formation of pseudohyphae, blastoconidia, and chlamydospores, ensuring the antifungal potential of this substance. It was also possible to identify the fungicidal profile of the test substance through the study of the growth kinetics of C. albicans. Finally, it was observed that the test compound inhibited the ergosterol biosynthesis by yeast. origin humans C albicans glabrata parapsilosis tropicalis E3furan2yl Efuranyl E 3 furan yl (E)-3-(furan-2-yl acrylate 6 51 μgmL μg mL μg/mL 25 respectively strains resistance virulence structures pseudohyphae blastoconidia chlamydospores Finally yeast 5

Amino sugars are chemical compounds that have a sugar backbone, in which one of the hydroxyl groups is replaced by an amino group. Derivatives of amine-containing sugars, such as N-acetylglucosamine, are also considered amino sugars. The synthetic introduction of amino functionalities in a regio- and stereoselective manner ontosugar scaffolds represents a substantial challenge. Most of the modern methods for the preparation of 1-, 2- and 3-amino sugars are those starting from glycals, 2,3-unsaturated O-glycosides epoxy-sugars, keto-sugars among others. This review summarizes recente developments in the current state of knowledge concerning the occurrence, biosynthesis, synthesis and application of amino sugars.

Resumo: Partindo das ideias de Bakhtin e inserindo-as no quadro mais amplo dos estudos discursivos, este trabalho analisa os elementos dos gêneros de discurso encontrado em textos de livros didáticos de química. Foram analisados 12 livros de química, destinados a estudantes da 1.a série do ensino médio, de escolas públicas e particulares. Três livros foram recomendados pelo Programa Nacional do Livro Didático (PNLD) 2012 e escolhidos por um número expressivo de professores da rede pública. O conteúdo objeto do estudo foi: ligações químicas. Foi possível identificar recapitulações, chamadas e metáforas (elementos do gênero didático); descrição, classificação, explicação e definição (elementos do gênero científico). O elemento contextualização foi pouco descrito nos livros analisadas. O uso de metáforas foi predominante no livro H.

Abstract: Using the ideas of Bakhtin and inserting them in the broader frame of discursive studies, this paper analyzes the elements of discursive genres found in chemistry textbooks texts. Chemistry twelve books were analyzed, aimed at students of the first high school series of public and private schools. Three books have been recommended by the National Textbook Program ‒ PNLD/2012 and chosen by a large number of public school teachers. The object of the study was content Chemical Bonds. It was possible to identify recaps, calls and metaphors (the didactic genre elements); description, classification, explanation and definition (the scientific genre elements). The context element was just described in the analyzed books. The use of metaphor was predominant in the book H.