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ABSTRACT Objective: The aim of this study was to evaluate monocyte subtypes and the chemokine receptors, comparing individuals with and without Chronic Venous Insufficiency (CVI). Method: The authors included patients undergoing surgery for varicose veins of the lower limbs (Classification of Venous Disorders - CEAP: C1-C3). Results: There were increased levels of classical and non-classical monocytes in the case group and a reduction in intermediate monocytes. Besides, there was higher expression of CCR5 in the non-classical monocytes and lower expression of CX3CR1 in the classical monocytes in the case group. Conclusions: The inflammatory process present in patients with CVI can modulate the monocyte phenotype and the expression of the chemokine receptors at the protein level.

https://doi.org/10.1016/j.clinsp.2025.100595

Political Administration: Contributions to the Theoretical-Analytical and Empirical Debate of Contemporary Administration
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Ribeiro, Elizabeth Matos

; Ribeiro, Mônica Matos

; Fonseca, Francisco César Pinto da

Revista de Administração Contemporânea

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2024, Volume 28 N. 5 elocation e240087

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: this paper aims to examine the contributions of Reginaldo Souza Santos' thought to the advancement of Contemporary Administration theory and practice. In doing so, it will consider the evolution of the theory of political administration from its conception to its present form. Thesis: the theory of Political Administration makes relevant contributions to the theory and practices of Contemporary Administration by recovering the possibilities, challenges and limits of Administration science in its subjective and objective aspects - political and technical - which underpin the purpose (intentionality), conception, movement and social purpose of this field of knowledge. Conclusions: (a) efforts undertaken by Reginaldo Santos, as expressed in the theory of Political Administration, contributed to the dialogue and renovation of the thinking of renowned Brazilian and Bahian thinkers, such as Guerreiro Ramos (1940-1982) and João Ubaldo Ribeiro (1968-2014). These thinkers were instrumental in inaugurating a critical debate about the (Social) Sciences of Administration and Organizational Studies; (b) innovations introduced by the theory of Political Administration allow for contending that the Brazilian academic demonstrates an important capacity for renewing the theoretical-critical debate on administrative (social) thought, particularly when defending the inseparability between theoretical-abstract aspects (from strategic management, or gestão) and administrative practices (from operational management, or gerência). In this sense, the theory of Political Administration has enabled production and dissemination of critical technologies and studies in management (public, private and social) committed to putting socially produced administrative-social knowledge and practices in service of promoting social welfare.

RESUMO Objetivo: reconhecer e discutir as contribuições do pensamento de Reginaldo Souza Santos para os avanços das teorias e práticas da administração contemporânea, considerando a concepção e a evolução da teoria da administração política. Tese: a teoria de administração política apresenta relevantes contribuições para a teoria e as práticas da administração contemporânea ao resgatar as possibilidades, desafios e limites da ciência da Administração nos seus aspectos subjetivos e objetivos - políticos e técnicos - que fundamentam o propósito (intencionalidade), a concepção, o movimento e a finalidade social desse campo do conhecimento. Conclusões: (a) os esforços empreendidos por Reginaldo Santos, expressos na teoria da administração política, contribuíram para o diálogo e a atualização do pensamento de renomados pensadores brasileiros e baianos, como Guerreiro Ramos (1940-1982) e João Ubaldo Ribeiro (1968-2014), responsáveis pela inauguração do debate crítico acerca das ciências (sociais) da administração e dos estudos organizacionais; (b) as inovações introduzidas pela teoria da administração política possibilitam sustentar que a acadêmica brasileira revela importante capacidade de renovação do debate teórico-crítico sobre o pensamento (social) administrativo, especialmente ao defender a indissociabilidade entre os aspectos teórico-abstratos (próprios da gestão) e as práticas administrativas (próprias da gerência). Nesse sentido, a teoria da administração política tem possibilitado a produção e difusão de estudos e tecnologias críticas em gestão (pública e social) comprometidas em colocar os saberes e práticas administrativo-sociais produzidos socialmente a serviço da promoção do bem-estar social.

https://doi.org/10.1590/1982-7849rac2024240087.en

Forty years of a Postgraduate Program in Cardiology at a Brazilian public university: indicators of its graduates
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Braga Filho, Carlos Eduardo

; Silva, Talita Dias da

; Silva, Claudia Joanete da

; Santos, Cleidivan Alves dos

; Rodrigues, Frank Menezes

; Barbosa, Adriano Henrique Pereira

; Caixeta, Adriano

; Izar, Maria Cristina de Oliveira

; Luna-Filho, Bráulio

; Fonseca, Francisco Antonio Helfenstein

; Tallo, Fernando Sabia

; Roever, Leonardo

; Caricati-Neto, Afonso

; Menezes-Rodrigues, Francisco Sandro

Acta Cirúrgica Brasileira

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2024, Volume 39 elocation e394824

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To evaluate the profile of graduates of the Postgraduate Program (PGP) in Cardiology of a public federal university, according to sociodemographic factors and professional trajectory. Methods: The variables were collected from databases from the observed institution and digital platforms. The analysis of differences between the various levels of degrees was carried out in three cohorts: the entire historical series (graduates from 1978–2021), the first 20 years (1978–1997) and the second 20 years (1998–2018). Results: The results demonstrated that most students from the PGP completed a PhD and are men over 30 years old, they came from public universities and the Southeast region. In the first 20 years, significant differences were observed in the distribution of masters and doctors working professionally at the institution analyzed, as well as in the age of the students. In the 20 years of the second half, there were differences between masters and PhD working professionally in the institution itself, as they came from private universities, they are women and PhD. Conclusions: The changes in the profile of masters and PhD that graduated from this PGP in cardiology reflect transformations that occurred in the job market and academy over the decades.

https://doi.org/10.1590/acb394824

Polyethyleneimine-mediated gene transfection in porcine fetal fibroblasts
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Souza, Andressa Pereira de

; Bastos, Ana Paula

; Fonseca, Francisco Noé da

; Pandolfi, José Rodrigo

; Costamilan, Carlos André da Veiga Lima Rosa

; Marques, Mariana Groke

Animal Reproduction

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2024, Volume 21 N. 4 elocation e20240026

Abstract: En | Text: En | PDF: En

Abstract Polyethylenimine (PEI) has been explored as an efficient non-viral system for delivering genes to cells; however, there were no protocols for its use in porcine fetal fibroblasts (PFF). Therefore, we compared different concentrations of FITC-PEI (0.625, 1.25, 2.5, 5, 10, 20, 40, or 80 µg/mL) and incubation times (30 min, 1 h, or 2 h). It was observed that the incubation time did not affect the internalization of the PEI-FITC and that 30 min was sufficient to capture the complex. The concentrations higher than 10 µg/mL could reach many marked PFF (>90%). Then, two PEI concentrations were tested, 10 or 40 µg/mL, combined with an N/P of 2 with the pmhyGENIE-5 for 30 min. The percentage of PFF-GFP positive was similar between the PEI concentrations in the evaluation time points (24 h, 48 h, and 72 h). However, 40 µg/mL caused higher membrane damage rates. Thus, it can be concluded that concentrations between 10 – 80 µg/ml of PEI promote high incorporation rates, even in periods as short as 30 minutes. Furthermore, it can be stated that the transfection condition used in Polyplexes 1 (10 µg/mL of PEI and 37.5 µg/mL of pmhyGENIE-5 for 30 min) efficiently produces genetically edited porcine fetal fibroblasts with low cell damage.

https://doi.org/10.1590/1984-3143-ar2024-0026

Posicionamento Brasileiro sobre Síndrome da Quilomicronemia Familiar – 2023 202 20 2
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Izar, Maria Cristina de Oliveira

; Santos Filho, Raul Dias dos

; Assad, Marcelo Heitor Vieira

; Chagas, Antonio Carlos Palandri

; Toledo Júnior, Alceu de Oliveira

; Nogueira, Ana Cláudia Cavalcante

; Souto, Ana Cristina Carneiro Fernandes

; Lottenberg, Ana Maria

; Chacra, Ana Paula Marte

; Ferreira, Carlos Eduardo dos Santos

; Lourenço, Charles Marques

; Valerio, Cynthia Melissa

; Cintra, Dennys Esper

; Fonseca, Francisco Antonio Helfenstein

; Campana, Gustavo Aguiar

; Bianco, Henrique Tria

; Lima, Josivan Gomes de

; Castelo, Maria Helane Costa Gurgel

; Scartezini, Marileia

; Moretti, Miguel Antonio

; Barreto, Natasha Slhessarenko Fraife

; Maia, Rayana Elias

; Montenegro Junior, Renan Magalhães

; Alves, Renato Jorge

; Figueiredo, Roberta Marcondes Machado

; Fock, Rodrigo Ambrosio Martinez, Tânia Leme da Rocha Giraldez, Viviane Zorzanelli Rocha

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 4 elocation e20230203

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.36660/abc.20230203

Estratégia Farmacoinvasiva em Idosos até 75 Anos ou Não Idosos: Análise de Parâmetros Bioquímicos e de Ressonância Nuclear Magnética Cardíaca 7
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Bacchin, Amanda S.

; Fonseca, Francisco A. H.

; Povoa, Rui

; Szarf, Gilberto

; Pinto, Ibraim Masciarelli Caixeta, Adriano Mendes Teixeira, Daniela Maugeri, Ieda Longo Ishimura, Mayari E. Coste, Maria E. R. Bianco, Henrique Tria França, Carolina N. Izar, Maria Cristina

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 1 elocation e20220177

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento A estratégia farmacoinvasiva é uma alternativa na inviabilidade da intervenção coronária percutânea primária (ICP). Objetivos Este estudo teve como objetivo avaliar os efeitos da estratégia farmacoinvasiva precoce sobre o tamanho da área infartada e a fração de ejeção ventricular esquerda em pacientes idosos e não idosos. O papel dos marcadores inflamatórios também foi avaliado. Métodos Pacientes (n=223) com infarto do miocárdio com elevação do segmento ST (IAMCSST) foram prospectivamente incluídos e submetidos à trombólise medicamentosa nas primeiras seis horas, e à angiografia coronariana e à ICP, quando necessária, nas primeiras 24 horas. As amostras de sangue foram coletadas no primeiro dia (D1) e 30 dias após (D30). A ressonância magnética cardíaca foi realizada no D30. O nível de significância estatística foi estabelecido em p<0,05. Resultados Pacientes idosos e não idosos apresentaram porcentagem similares de massa infartada [13,7 (6,9-17,0) vs. 14,0 (7,3-26,0), respectivamente p=0,13)] [mediana (intervalo interquartil)]. No entanto, os pacientes idosos apresentaram maior fração de ejeção ventricular esquerda [53 (45-62) vs. 49 (39-58), p=0,025)]. As concentrações de interleucina (IL)1beta, IL-4, IL-6, e IL-10 não foram diferentes entre D1 e D30, mas pacientes idosos apresentaram níveis mais elevados de IL-18 em D1 e D30. O número absoluto de linfócitos B e T foram similares em ambos os grupos em D1 e D30, porém, pacientes idosos apresentaram uma razão neutrófilo-linfócito mais alta em D30. A análise de regressão linear multivariada dos desfechos de RMC de toda a população do estudo mostrou que os preditores independentes não foram diferentes entre pacientes idosos e não idosos. Conclusão A estratégia farmacoinvasiva em pacientes idosos foi associada a pequenas diferenças nos parâmetros inflamatórios, tamanho do infarto similar, e melhor função ventricular esquerda em comparação a pacientes não idosos ICP. ICP . (ICP) avaliado n=223 n223 n 223 (n=223 IAMCSST (IAMCSST horas necessária 2 D (D1 3 D30 (D30) p005 p 0 05 p<0,05 13,7 137 13 7 [13, 6,917,0 69170 6,9 17,0 6 9 17 (6,9-17,0 vs 140 14 14, 7,326,0, 73260 7,3 26,0 , 26 (7,3-26,0) p=0,13 p013 p=0,13) mediana intervalo interquartil. interquartil interquartil)] entanto 53 [5 4562 45 62 (45-62 4 3958, 3958 39 58 (39-58) p=0,025. p0025 p=0,025 025 p=0,025)] IL1beta, IL1beta ILbeta IL 1beta, 1beta beta (IL)1beta IL4, IL4 4, IL-4 IL6, IL6 6, IL-6 IL10 10 IL-1 IL18 18 porém neutrófilolinfócito neutrófilo linfócito similar (ICP n=22 n22 22 (n=22 (D D3 (D30 p00 p<0,0 13, 1 [13 917 6,917, 6917 69 170 17, (6,9-17, 326 7,326,0 7326 73 7, 260 26, (7,3-26,0 p=0,1 p01 interquartil) 5 [ 456 (45-6 395 (39-58 p002 p=0,02 02 p=0,025) IL- IL1 n=2 n2 (n=2 (D3 p0 p<0, [1 91 6,917 691 (6,9-17 32 7,326, 732 (7,3-26, p=0, (45- (39-5 p=0,0 n= (n= p<0 6,91 (6,9-1 7,326 (7,3-26 p=0 (45 (39- (n p< (6,9- 7,32 (7,3-2 p= (4 (39 (6,9 (7,3- ( (3 (6, (7,3 (6 (7, (7

Abstract Background Pharmacoinvasive strategy is an alternative when primary percutaneous coronary intervention (PCI) is not feasible. Objectives This study aimed to evaluate the effects of early pharmacoinvasive strategy on the infarct size and left ventricular ejection fraction in elderly and non-elderly patients. The role of inflammatory markers was also examined. Methods Patients (n=223) with ST segment elevation myocardial infarction (STEMI) were prospectively included and submitted to pharmacological thrombolysis in the first six hours, and underwent coronary angiogram and PCI when necessary, in the first 24 hours. Blood samples were collected in the first day (D1) and after 30 days (D30). Cardiac magnetic resonance imaging (cMRI) was performed at D30. Significance was set at p<0.05. Results Elderly and non-elderly patients showed similar percentage of infarcted mass (13.7 [6.9-17.0] vs. 14.0 [7.3-26.0], respectively, p=0.13) (median [interquartile range]). However, elderly patients had better left ventricular ejection fraction (53 [45-62] vs. 49 [39-58], p=0.025). Titers of interleukin (IL)1beta, IL-4, IL-6, and IL-10 did not differ between D1 and D30, but elderly patients had higher titers for IL-18 at D1 and D30. Absolute numbers of B and T lymphocytes were similar in both groups at D1 and D30, but elderly patients had higher neutrophil/lymphocyte ratio at D30. Multivariate linear regression analysis of cMRI outcomes in the whole population showed that the independent predictors were not different between elderly and non-elderly patients. Conclusion Pharmacoinvasive strategy in elderly patients was associated with small differences in inflammatory parameters, similar infarct size and better left ventricular function than non-elderly patients. (PCI feasible nonelderly non examined n=223 n223 n 223 (n=223 STEMI (STEMI hours necessary 2 D (D1 3 D30 . (D30) (cMRI p005 p 0 05 p<0.05 13.7 137 13 7 (13. 6.917.0 69170 6.9 17.0 6 9 17 [6.9-17.0 vs 140 14 14. 7.326.0, 73260 7.3 26.0 , 26 [7.3-26.0] respectively p=0.13 p013 median interquartile range. range range]) However 53 (5 4562 45 62 [45-62 4 3958, 3958 39 58 [39-58] p=0.025. p0025 p=0.025 025 p=0.025) IL1beta, IL1beta ILbeta IL 1beta, 1beta beta (IL)1beta IL4, IL4 4, IL-4 IL6, IL6 6, IL-6 IL10 10 IL-1 IL18 18 neutrophillymphocyte neutrophil lymphocyte parameters n=22 n22 22 (n=22 (D D3 (D30 p00 p<0.0 13. 1 (13 917 6.917. 6917 69 6. 170 17. [6.9-17. 326 7.326.0 7326 73 7. 260 26. [7.3-26.0 p=0.1 p01 range] 5 ( 456 [45-6 395 [39-58 p002 p=0.02 02 IL- IL1 n=2 n2 (n=2 (D3 p0 p<0. (1 91 6.917 691 [6.9-17 32 7.326. 732 [7.3-26. p=0. [45- [39-5 p=0.0 n= (n= p<0 6.91 [6.9-1 7.326 [7.3-26 p=0 [45 [39- (n p< [6.9- 7.32 [7.3-2 p= [4 [39 [6.9 [7.3- [ [3 [6. [7.3 [6 [7. [7

https://doi.org/10.36660/abc.20220177

Relação da Ascensão Matinal da Pressão Arterial com a Hipertrofia Ventricular Esquerda em Hipertensos Obesos
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Palmeira, Natascha Gonçalves Francisco

; Bianco, Henrique Tria

; Bombig, Maria Teresa Nogueira

; Povoa, Fernando Focaccia

; Fonseca, Francisco A. H.

; Izar, Maria Cristina

; Thalenberg, José Marcos Luna Filho, Braulio Marui, Fabiane Fischer, Simone Matheus Amodeo, Celso Souza, Dilma do Socorro Moraes de Povoa, Rui

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 9 elocation e20230050

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background Weight gain can trigger mechanisms that increase blood pressure. Nevertheless, obesity causes structural changes in the myocardium, including increased ventricular mass, atrial dilatation, and diastolic and systolic dysfunction. Additionally, blood pressure variations, like morning surge (MS) in obese hypertensive patients may have clinical relevance in cardiovascular events. Although morning blood pressure surge is a physiological phenomenon, excess MS can be considered an independent risk factor for cardiovascular events. Objective To evaluate MS values and their association with left ventricular hypertrophy (LVH) and nocturnal dipping (ND) in obese and non-obese hypertensive patients. Methods A cross-sectional study that evaluated BP measurements by ambulatory blood pressure monitoring (ABPM) and the presence of LVH by echocardiography in 203 hypertensive outpatients, divided into two groups: 109 non-obese and 94 obese hypertensives patients. The significance level was set at 0.05 in two-tailed tests. Results A MS above 20 mmHg by ABPM was detected in 59.2% of patients in the non-obese group and 40.6% in the obese group. LVH was found in 18.1% and 39.3% of patients in the non-obese and obese groups, respectively, p<0.001. In the “obese group”, it was observed that a MS>16 mmHg was associated with LVH, [prevalence ratio: 2.80; 95%CI (1.12–6.98), p=0.03]. For the non-obese group, the cut-off point of MS for this association was >22 mmHg. Conclusion High MS was positively associated with LVH, with a particular behavior in the hypertensive obese group.

Resumo Fundamento O aumento do peso frequentemente desencadeia mecanismos que elevam a pressão arterial. A obesidade causa mudanças estruturais no miocárdio, incluindo aumento da massa ventricular, dilatação atrial, bem como disfunções diastólicas e sistólicas. Além disso, variações pressóricas nos hipertensos obesos, como a ascensão matinal (AM), podem ter relevância clínica na prevenção dos eventos cardiovasculares. A AM da pressão arterial é um fenômeno fisiológico, que quando elevada pode ser considerada um fator de risco independente para eventos cardiovasculares. Objetivo Avaliar valores da elevação da AM e sua associação com a hipertrofia ventricular esquerda (HVE) e com o Descenso do Sono (DS) em obesos e não obesos hipertensos. Métodos Estudo transversal que avaliou medidas pressóricas à monitorização ambulatorial da pressão arterial (MAPA) e a presença de HVE, avaliada pela ecocardiografia, em 203 pacientes hipertensos em tratamento ambulatorial, separados em dois grupos: 109 não obesos e 94 hipertensos obesos. O nível de significância adotado foi de 0,05 em testes bicaudais. Resultados A AM acima de 20 mmHg à MAPA foi detectada em 59,2% dos pacientes do grupo “não obesos” e em 40,6% no grupo “obesos”. A HVE foi encontrada em 18,1% no grupo dos não-obesos e em 39,3% no grupo de obesos, p<0,001. No grupo “obesos” foi observado que AM >16 mmHg esteve associada à HVE, com [razão de prevalência: 2,80; IC95% (1,12–6,98), p=0,03]. Para o grupo dos “não obesos”, o ponto de corte da AM para essa associação foi >22 mmHg. Conclusão A AM elevada associou-se positivamente com HVE, com comportamento peculiar na população de hipertensos e obesos.

https://doi.org/10.36660/abc.20230050

Os Pacientes de Baixo Risco Cardiovascular Poderiam Ser Melhor Estratificados?
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Fonseca, Francisco Antonio Helfenstein

; Izar, Maria Cristina

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 6 elocation e20230310

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20230310

Inflammation in Cardiovascular Disease: Current Status and Future Perspectives
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Fonseca, Francisco Antonio Helfenstein

; Izar, Maria Cristina

International Journal of Cardiovascular Sciences

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2023, Volume 36 elocation e20230072

Abstract: En | Text: En | PDF: En

Abstract Atherosclerosis has been defined as an inflammatory disease. Three decades of research have pointed to a pivotal role of interleukin 6 for many aspects of cardiovascular disease, not the least of which is atherosclerosis. In this review, experimental and clinical studies are reported on a timeline, exploring mechanisms and possible explanations that form the basis of current knowledge. Some successful clinical trials were proof of concept studies, showing that not only inflammatory biomarkers are related to cardiovascular outcomes, but also that decreasing inflammation can reduce cardiovascular events. Great advances have been made in the management of residual cardiovascular risk due to cholesterol, thrombosis, and metabolic diseases, but the next frontier now seems to be targeting inflammation. In the upcoming years, the importance of inflammation will be evaluated in high-risk patients with chronic kidney disease, after acute coronary heart disease or heart failure with preserved ejection fraction. Inflammation seems to precede the development of cardiovascular risk factors. Moreover, counseling for a heathy lifestyle and, when necessary, the use of cardiometabolic therapies capable of decreasing inflammation, might be important.

https://doi.org/10.36660/ijcs.20230072

10.

Antimicrobial and Cytotoxic Bioprospection of Thymus vulgaris and Thymol Against Salmonella enterica Serovar Heidelberg Isolated in Broiler Chicken
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Sperandio, Jhonatan

; Bastos, Ana Paula Almeida

; Fonseca, Francisco Noé da

; Bellaver, Franciana Aparecida Volpato

; Bello, Thais Carla Dal

; Kuhnen, Shirley

; Millezi, Alessandra Farias

Brazilian Archives of Biology and Technology

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2023, Volume 66 elocation e220210502

Abstract: En | Text: En | PDF: En

Abstract Salmonella enterica serovar Heidelberg (SH), often isolated from broiler chicken samples, damages the entire production chain due to its high resistance in the environment. The search for sustainable disinfectant agents has intensified, focusing on the action of essential oils. This work's objective was to evaluate the in vitro, effect of Thymus vulgaris essential oil (TEO) and thymol in SH isolated from broilers, and the cytotoxicity in animal cells. Four different concentrations of TEO (0.1%, 0.2%, 0.4%, and 0.8%, (v/v)) were used against five SH isolates obtained from broilers and ATCC 8326. Thymol was evaluated at the concentrations of 0.023%, 0.047%, 0.071%, and 0.094% (v/v). In vitro antibacterial assays were performed by quantifying viable planktonic cells in the broth microdilution test. The MTT technique was used to assess the cytotoxicity in IEC-6 intestinal cells and NCTC fibroblasts. IC50 was assessed testing the concentrations of 0.0625%, 0.125%, 0.25%, and 0.5% of TEO and thymol in 24 hours. The bacterial activity was observed from the 0.2% concentration of TEO since no colony-forming units were observed. Thymol in the concentration of 0.094% controlled 83.33% of the bacteria. TEO presented an IC50 of 0.14% and 1.22%, while the IC50 for thymol was 0.068% and 0.001% for the IEC-6 and NCTC cells, respectively. On the other hand, TEO showed low cytotoxicity in fibroblasts and a potential action capacity to eliminate SH strains in vitro.

https://doi.org/10.1590/1678-4324-2023210502

11.

Macrófagos e Neovascularização na Neoaterosclerose Intra-Stent: um Fenótipo Inflamatório Acelerado por OCT com Implicações Terapêuticas
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Izar, Maria Cristina Oliveira

; Fonseca, Francisco A. H.

Arquivos Brasileiros de Cardiologia

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dec 2022, Volume 119 N. 6 Pages 938 - 939

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20220732

12.

Estratégia Fármaco-Invasiva no Infarto do Miocárdio: Análise Descritiva, Apresentação de Sintomas Isquêmicos e Preditores de Mortalidade
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Bianco, Henrique Tria

; Povoa, Rui

; Izar, Maria Cristina

; Alves, Claudia Maria Rodrigues

; Barbosa, Adriano Henrique Pereira

; Bombig, Maria Teresa Nogueira

; Gonçalves Jr, Iran

; Luna Filho, Bráulio Aguirre, Ana Caroline Moraes, Pedro Ivo de Marqui Almeida, Dirceu Moreira, Flávio Tocci Povoa, Fernando Focaccia Stefanini, Edson Caixeta, Adriano Mendes Bacchin, Amanda S. Moisés, Valdir Ambrósio Fonseca, Francisco A.H.

Arquivos Brasileiros de Cardiologia

Journal Metrics
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nov 2022, Volume 119 N. 5 Pages 691 - 702

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background ST-segment elevation myocardial infarction (STEMI) is defined by symptoms accompanied by typical electrocardiogram changes. However, the characterization of ischemic symptoms is unclear, especially in subgroups such as women and the elderly. Objectives To analyze the typification of ischemic symptoms, temporal metrics and observe the occurrence of in-hospital outcomes, in the analysis of predictive scores, in patients with STEMI, in a drug-invasive strategy. Methods Study involving 2,290 patients. Types of predefined clinical presentations: typical pain, atypical pain, dyspnea, syncope. We measured the time between the onset of symptoms and demand for care and the interval between arrival at the medical unit and thrombolysis. Odds-ratios (OR; CI-95%) were estimated in a regression model. ROC curves were constructed for mortality predictors. The adopted significance level (alpha) was 5%. Results Women had a high prevalence of atypical symptoms; longer time between the onset of symptoms and seeking care; delay between arrival at the emergency room and fibrinolysis. Hospital mortality was 5.6%. Risk prediction by Killip-Kimball classification: AUC: [0.77 (0.73-0.81)] in class ≥II. Subgroups studied [OR (CI-95%)]: women [2.06 (1.42-2.99); p=0.01]; chronic renal failure [3.39 (2.13-5.42); p<0.001]; elderly [2.09 (1.37-3.19) p<0.001]; diabetics [1.55 (1.04-2.29); p=0.02]; obese 1.56 [(1.01-2.40); p=0.04]: previous stroke [2.01 (1.02-3.96); p=0.04] correlated with higher mortality rates. Conclusion Despite higher mortality rates in some subgroups, significant disparity persists in women, with delays in symptom recognition and prompt thrombolysis. We highlight the applicability of the Killip-Kimball score in prediction, regardless of the clinical presentation.

Resumo Fundamento O infarto do miocárdio com elevação do segmento-ST (IAMCSST) é definido por sintomas acompanhados por alterações típicas do eletrocardiograma. Entretanto, a caracterização dos sintomas isquêmicos não é clara, principalmente em subgrupos, como mulheres e idosos. Objetivos Analisar a tipificação dos sintomas isquêmicos, métricas temporais e observar a ocorrência de desfechos intra-hospitalares, em análise dos escores preditivos, em pacientes com IAMCSST, em estratégia fármaco-invasiva. Métodos Estudo envolvendo 2.290 pacientes. Tipos de apresentações clínicas pré-definidas: dor típica, dor atípica, dispnéia, sincope. Medimos o tempo entre o início dos sintomas à demanda pelo atendimento e o intervalo entre a chegada à unidade-médica e trombólise. Odds-ratios (OR; IC-95%) foram estimadas em modelo de regressão. Curvas ROCs foram construídas para preditores de mortalidade. Nível de significância adotado (alfa) foi de 5%. Resultados Mulheres apresentaram alta prevalência de sintomas atípicos; maior tempo entre o início dos sintomas e a procura por atendimento; atraso entre a chegada ao pronto-socorro e a fibrinólise. A mortalidade hospitalar foi de 5,6%. Predição de risco pela classificação Killip-Kimball: AUC: [0,77 (0,73-0,81)] em classe ≥II. Subgrupos estudados [OR (IC-95%)]: mulheres [2,06 (1,42-2,99); p=0,01]; insuficiência renal crônica [3,39 (2,13-5,42); p<0,001]; idosos [2,09 (1,37-3,19) p<0,001]; diabéticos [1,55 (1,04-2,29); p=0,02]; obesos 1,56 [(1,01-2,40); p=0,04]; acidente vascular cerebral prévio [2,01 (1,02-3,96); p=0,04] correlacionaram-se com maiores taxas de mortalidade. Conclusão Apesar das mais altas taxas de mortalidade em alguns subgrupos, disparidade significativa persiste nas mulheres, com atrasos no reconhecimento dos sintomas e trombólise imediata. Destaca-se a aplicabilidade do escore Killip-Kimball na predição, independentemente da apresentação clínica.

https://doi.org/10.36660/abc.20211055

13.

Variabilidade da Pressão Arterial e do Risco Cardiovascular no ELSA-Brasil: Um Potencial Marcador Substituto para Predizer Mortalidade e Desfechos Cardiovasculares?
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Izar, Maria Cristina

; Fonseca, Francisco A. H.

Arquivos Brasileiros de Cardiologia

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oct 2022, Volume 119 N. 4 Pages 512 - 513

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20220525

14.

Triagem Direcionada da Hipercolesterolemia Familiar em 11 Pequenas Cidades Brasileiras: Uma Abordagem Eficaz para Detectar Agrupamentos de Indivíduos Afetados
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Izar, Maria Cristina Oliveira

; Fonseca, Francisco A. H.

Arquivos Brasileiros de Cardiologia

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apr 2022, Volume 118 N. 4 Pages 678 - 679

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20220027

15.

Evaluation of pulse wave velocity and central systolic blood pressure in children and adolescents with chronic kidney disease
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Brecheret, Ana Paula

; Abreu, Ana Lucia Cardoso Santos

; Lopes, Renata

; Fonseca, Francisco Antônio Helfenstein

; Solé, Dirceu

; Andrade, Maria Cristina de

einstein (São Paulo)

Journal Metrics
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2022, Volume 20 elocation eAO6758

Abstract: En | Text: En | PDF: En

ABSTRACT Objective Investigate pulse wave velocity and central systolic blood pressure among pediatric population with chronic kidney disease. Methods In this cross-sectional study, 57 patients (61.4% male) aged 6.2 to 17.5 years old, 44 with nondialysis chronic kidney disease and 13 on chronic dialysis, were included in the analysis. The pulse wave velocity and the central systolic blood pressure were measured with an oscillometric device with an inbuilt ARC SolverⓇ algorithm and were compared with previously established percentiles. Results The prevalence of elevated pulse wave velocity was 21.1% (95%Cl: 11.4-33.9) and elevated central systolic blood pressure was 28.1% (95%CI: 17.0-41.5). According to the generalized linear model, there was a higher risk of elevated pulse wave velocity in patients undergoing chronic dialysis treatment than nondialysis chronic kidney disease patients (adjPR=4.24, 95%CI: 1.97-9.13, p=<0.001). Hypertensive patients (stage 2) had a higher risk of elevated pulse wave velocity than normotensive ones (adjPR=2.70, 95%CI: 1.05-6.95, p=0.040), as did patients younger than 12 years than the older patients (adjPR=2.95, 95%CI: 1.05-8.40, p=0.041). Hypertensive patients had a higher risk of elevated central systolic blood pressure than normotensives (adjPR=3.29, 95%Cl: 1.36-7.94), as did patients undergoing chronic dialysis treatment when comparing to nondialysis chronic kidney disease patients (adjPR=2.08, 95%Cl: 1.07-4.02). Conclusion Younger age, dialysis, and hypertension in children are independently associated with higher pulse wave velocity. Hypertension and dialysis are independently associated with higher central systolic blood pressure.

https://doi.org/10.31744/einstein_journal/2022ao6758

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