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Abstract Orally disintegrating films (ODFs) were prepared from hydroxypropyl methylcellulose (HPMC E6 1.5%, 2.0%, and 2.5%), plasticizers ((glycerin (Gly), propylene glycol (PP), or polyethylene glycol (PEG)), and isosorbide dinitrate using the solvent casting method. Design of experiments (DoE) was used considering the amount of film-forming agent (HPMC) and the nature of the plasticizers as independent variables and thickness, mechanical properties, disintegration time, and dissolution efficiency as dependent variables. The best formulation was selected based on the desirability function ( f D). Color analysis was performed using CIE- L a b coordinates. DSC curves and XRPD diffractograms showed ISDN amorphization, probably due to complexation with polymers (HPMC E6 and HPβCD). The polymer (HPMC E6) and plasticizer played a critical role in the mechanical and optical properties of the films; however, these factors had no significant effect on the dissolution efficiency of ISDN. Principal component analysis revealed a more defined distinction of the ODFs according to their chromatic characteristics. ODFs prepared with Gly and PEG 400 were translucent, whereas the other films were transparent. The dissolution efficiency values of the ODFs (F1-9) were higher than those observed for the reference product (88.35(0.01%), indicating increased solubility of ISDN, probably due to complexation with polymers (HPMC E6 and HPβCD). The maximum value obtained for desirability function ( f D ) was 0.86, which corresponded to the use of 1.5% to 2.0% polymer (HPMC E6) and Gly or PP as plasticizers. The F5 formulation showed adequate thickness (85.00(6.38 (m), elongation at break (4.82(0.01%), adhesiveness (0.23(0.09 mJ), dissolution efficiency (95.97(0.01%), and high transparency. (ODFs HPMC E 15 1 5 20 2 0 2.5%, 25 2.5% , 2.5%) glycerin Gly, (Gly) PP, (PP) PEG, (PEG)) method DoE (DoE filmforming film forming time D. . D) CIE coordinates amorphization HPβCD. HPβCD HPβCD) however characteristics 40 translucent transparent F19 F F1 9 (F1-9 88.350.01%, 8835001 88.35 0.01% 88 35 01 (88.35(0.01%) 086 86 0.86 1.5 2.0 85.006.38 8500638 85.00 6.38 85 00 6 38 (85.00(6.3 m, m (m) 4.820.01%, 482001 4.82 4 82 (4.82(0.01%) 0.230.09 023009 0.23 0.09 23 09 (0.23(0.0 mJ, mJ mJ) 95.970.01%, 9597001 95.97 95 97 (95.97(0.01%) transparency 2.5 (Gly (PP (PEG) (F1- 350 88.350.01% 883500 8835 88.3 001 0.01 8 3 (88.35(0.01% 08 0.8 1. 2. 006 85.006.3 850063 8500 85.0 638 6.3 (85.00(6. (m 820 4.820.01% 48200 482 4.8 (4.82(0.01% 230 0.230.0 02300 023 0.2 009 0.0 (0.23(0. 970 95.970.01% 959700 9597 95.9 (95.97(0.01% (PEG (F1 88.350.01 88350 883 88. (88.35(0.01 0. 85.006. 85006 850 85. 63 6. (85.00(6 4.820.01 4820 48 4. (4.82(0.01 0.230. 0230 02 (0.23(0 95.970.01 95970 959 95. (95.97(0.01 (F 88.350.0 (88.35(0.0 85.006 (85.00( 4.820.0 (4.82(0.0 0.230 (0.23( 95.970.0 (95.97(0.0 88.350. (88.35(0. (85.00 4.820. (4.82(0. (0.23 95.970. (95.97(0. 88.350 (88.35(0 (85.0 4.820 (4.82(0 (0.2 95.970 (95.97(0 (88.35( (85. (4.82( (0. (95.97( (88.35 (85 (4.82 (0 (95.97 (88.3 (8 (4.8 (95.9 (88. (4. (95. (88 (4 (95 (9